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https://www.readbyqxmd.com/read/27918615/top-down-control-of-methane-emission-and-nitrogen-cycling-by-waterfowl
#1
R Scott Winton, Curtis J Richardson
Aquatic herbivores impose top-down control on the structure of wetland ecosystems, but the biogeochemical consequences of herbivory on methane (CH4 ) and nitrogen (N) are poorly known. To investigate the top-down effects of waterfowl on wetland biogeochemistry, we implemented exclosure experiments in a major waterfowl overwintering wetland in the southeastern United States over two growing seasons. We found that herbivory inhibited the oxidation of CH4 , leading to a mean increase in emission by 230% over control plots, and prevented nitrification, as indicated by low nitrate availability and undetectable emissions of nitrous oxide...
November 4, 2016: Ecology
https://www.readbyqxmd.com/read/27916731/associations-between-the-cntnap2-gene-dorsolateral-prefrontal-cortex-and-cognitive-performance-on-the-stroop-task
#2
Bi Zhu, Chuansheng Chen, Gui Xue, Xuemei Lei, Yunxin Wang, Jin Li, Robert K Moyzis, Jun Li, Qi Dong, Chongde Lin
The CNTNAP2 (contactin associated protein-like 2) gene, highly expressed in the human prefrontal cortex, has been linked with autism and language impairment. Potential relationships between CNTNAP2, dorsolateral prefrontal cortex (DLPFC), and cognition have been suggested by previous clinical studies, but have not been directly examined in the same study. The current study collected structural MRI, genetic, and behavioral data in 317 healthy Chinese adults, and examined associations between CNTNAP2 variants, DLPFC, and cognitive performance (measured by the Stroop task)...
December 1, 2016: Neuroscience
https://www.readbyqxmd.com/read/27916259/cyp-genetic-variants-cyp-metabolite-levels-and-neurologic-deterioration-in-acute-ischemic-stroke-in-chinese-population
#3
Xingyang Yi, Jing Lin, Chun Wang, Qiang Zhou
BACKGROUND: The mechanisms of neurologic deterioration (ND) are not fully understood. The aim of the present study was to evaluate the relationship between CYP genetic variants and CYP metabolite levels with ND in acute ischemic stroke patients. METHODS: Eleven single nucleotide polymorphisms (SNPs) of seven CYP genes were genotyped in 396 patients with acute ischemic stroke. The CYP plasma metabolite levels (20-hydroxyeicosatetraenoic acid [HETE], total epoxyeicosatrienoic acids [EETs], and dihydroxyeicosatrienoic acids [DiHETEs]) were also assessed...
December 1, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27915341/rs1501299-polymorphism-in-the-adiponectin-gene-and-their-association-with-total-adiponectin-levels-insulin-resistance-and-metabolic-syndrome-in-obese-subjects
#4
Daniel Antonio de Luis, Olatz Izaola, Beatriz de la Fuente, David Primo, Hilda Fernandez Ovalle, Enrique Romero
BACKGROUND AND AIMS: The aim of this study was to determine the association of single nucleotide polymorphism rs1501299 in the ADIPOQ gene with body weight, insulin resistance, serum adipokine levels and metabolic syndrome (MetS). METHODS: The study involved a population of 1,007 adult obese subjects. Parameters like body weight, fat mass, waist circumferences, blood pressure, fasting blood glucose, C-reactive protein, insulin concentration, homeostasis model assessment for insulin resistance (HOMA-IR), lipid profile and adipocytokines levels (leptin, adiponectin and resistin) were all measured...
December 3, 2016: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/27913202/adiponectin-gene-polymorphism-and-ischemic-stroke-subtypes-in-a-chinese-population
#5
Shanshan Li, Ning Lu, Zhongnan Li, Bin Jiao, Hanping Wang, Jia Yang, Tao Yu
As an adipose tissue-specific protein, adiponectin has been suggested as a protective factor for stroke, acting through anti-inflammatory and antiatherogenic effects. Therefore, we aimed to investigate whether 3 polymorphisms (rs1501299, rs2241767, and rs3774261) in the adiponectin (ADIPOQ) gene and their haplotypes were associated with ischemic stroke (IS) and its subtypes in a Chinese population. ADIPOQ gene rs1501299, rs2241767, and rs3774261 polymorphisms were analyzed in 385 IS patients, including 182 patients with large-artery atherosclerosis (LAA), 203 patients with small-vessel occlusion (SVO), and 418 matched controls...
November 29, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27911870/mir-146a-polymorphism-correlates-with-lung-cancer-risk-in-chinese-nonsmoking-females
#6
Zhihua Yin, Zhigang Cui, Yangwu Ren, Lingzi Xia, Hang Li, Baosen Zhou
This study provides evidence that the common rs2910164 polymorphism in miR-146a strongly correlates with lung cancer risk in nonsmoking females in northeast China. The genotypes of miR-146a rs2910164 were determined in 1131 patients with lung cancer and 1003 healthy control subjects. Tissue samples were used to evaluate the association between miRNA expression and lung cancer risk as well as the correlation between rs2910164 genotypes and miR-146a expression. The secondary structures of the wild-type and variant miR-146a sequences were predicted, and luciferase-based target assays were used to test whether miR-146a bound to tumor necrosis factor receptor associated factor 6 (TRAF6) mRNA...
November 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/27910733/a-comparative-morphologic-and-morphometric-study-about-geniculate-ganglion-development-in-man-and-in-rat
#7
Ana Sánchez-Del-Rey, José Maria Sánchez-Fernández, Arantza Ibargutxi, Agustin Martinez-Ibargüen, Francisco Santaolalla
CONCLUSIONS: Human-rat geniculate ganglion (GG) have multiple origins: (1) An initial proximity (20 μm) to the endocranial foramen of the IAM, suggests neural crest induction; and (2) The influence of epibranchial placodes: the tensor tympani muscle (TTM) and the otic apical coil. OBJECTIVES: This study was undertaken to determine the comparative development of human-rat GG. MATERIALS AND METHODS: A light microscopic study of the GG in human material obtained from spontaneous abortions at 9, 13, 14, 17, 18, and 30 weeks, and one neonate was done...
December 2, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27909914/association-of-snp-variants-of-mhc-class-ii-drb-gene-with-thermo-physiological-traits-in-tropical-goats
#8
Abdulmojeed Yakubu, Adebowale E Salako, Marcos De Donato, Sunday O Peters, Michael I Takeet, Mathew Wheto, Moses Okpeku, Ikhide G Imumorin
Host defense in vertebrates depend on many secreted regulatory proteins such as major histocompatibility complex (MHC) class II which provide important regulatory and effector functions of T cells. Gene polymorphism in the second exon of Capra-DRB gene in three major Nigerian goat breeds [West African Dwarf (WAD), Red Sokoto (RS), and Sahel (SH)] was analyzed by restriction fragment length polymorphisms (RFLP). Four restriction enzymes, BsaHI, AluI, HaeIII, and SacII, were utilized. The association between the polymorphic sites and some heat tolerance traits were also investigated in a total of 70 WAD, 90 RS, and 50 SH goats...
December 1, 2016: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/27906615/polymorphism-in-exon-6-of-the-human-nt5e-gene-is-associated-with-aortic-valve-calcification
#9
Zdzislaw Kochan, Joanna Karbowska, Patrycja Gogga, Barbara Kutryb-Zajac, Ewa M Slominska, Ryszard T Smolenski
NT5E encodes ecto-5'-nucleotidase (e5NT, CD73) which hydrolyses extracellular AMP to adenosine. Adenosine has been shown to play a protective role against aortic valve calcification (AVC). We identified two nonsynonymous missense single nucleotide polymorphisms (c.1126A > G, p.T376A and c.1136T > C, p.M379T) in exon 6 of the human NT5E gene. Since both substitutions might affect e5NT activity and consequently alter extracellular adenosine levels, we evaluated the association between NT5E alleles and calcific aortic valve disease in 119 patients (95 patients with AVC and 24 controls)...
December 2016: Nucleosides, Nucleotides & Nucleic Acids
https://www.readbyqxmd.com/read/27906429/the-role-of-the-enos-g894t-and-t-786c-gene-polymorphism-in-the-development-of-ascites-in-cirrhosis
#10
O Yildirim, A Yigit, Y Seckin, E Yesilada, G Gulbay, Y F Cagin, Z Aksungur, Y Bilgic, Y Türkoz, S Yologlu
OBJECTIVE: Increased nitric oxide (NO) production in cirrhotic patients causes splanchnic vasodilation, leading to the development of the hyperdynamic circulatory syndrome. One factor that influences plasma NO concentration is eNOS gene polymorphism; consequently, the aim of this study was to investigate whether the eNOS gene G894T and T-786C polymorphisms play any role in the development of ascites in such patients. PATIENTS AND METHODS: Three groups were created: 70 cirrhotic patients with ascites, 69 cirrhotic participants without ascites (stable cirrhosis), and 60 healthy controls...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27904507/impact-of-variants-in-cetp-and-apo-ai-genes-on-serum-hdl-cholesterol-levels-in-men-and-women-from-the-polish-population
#11
Marta Włodarczyk, Małgorzata Wrzosek, Grażyna Nowicka, Beata Jabłonowska-Lietz
INTRODUCTION: Polymorphisms in the cholesterol ester transfer protein (CETP) gene and apolipoprotein AI (apo AI) gene are identified as the most common genetic factors influencing high-density lipoprotein cholesterol (HDL cholesterol) levels. Low HDL cholesterol is an important risk factor for cardiovascular disease. We investigated the effect of the TaqIB polymorphism of the CETP gene and the 75G/A polymorphism of the apo AI gene on the HDL cholesterol concentration in a sample of Polish adults...
December 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27903758/oprm1-and-comt-gene-gene-interaction-is-associated-with-postoperative-pain-and-opioid-consumption-after-orthopedic-trauma
#12
Heba Khalil, Susan M Sereika, Feng Dai, Sheila Alexander, Yvette Conley, Gary Gruen, Li Meng, Peter Siska, Ivan Tarkin, Richard Henker
BACKGROUND: mu-opioid receptor (OPRM1) and catechol-O-methyltransferase (COMT) contribute to the neurotransmission pathway of pain. COMT affects mu receptor expression and density in the brain. The aim of this study was to explore the OPRM1 and COMT interaction effects on postoperative pain and opioid consumption. METHODS: This cross-sectional exploratory study used genotype and clinical data from 153 postoperative patients. Using multiple regression analyses, four single-nucleotide polymorphisms of COMT (rs6269, rs4633, rs4818, and rs4680), their haplotypes, and diplotypes were considered for their interactions with A118G of OPRM1 regarding postoperative pain and opioid consumption...
November 30, 2016: Biological Research for Nursing
https://www.readbyqxmd.com/read/27901485/mir-146a-rs2910164-polymorphism-and-head-and-neck-carcinoma-risk-a-meta-analysis-based-on-10-case-control-studies
#13
Zhaolan Xiang, Jue Song, Xianlu Zhuo, Qi Li, Xueyuan Zhang
Two recent meta-analyses have been conducted on the relationship between miR-146a polymorphism (rs2910164) and head and neck cancer (HNC) risk. However, they have yielded conflicting results. Hence, the aim of the present study was to conduct a quantitative updated meta-analysis addressing this subject. Eligible studies up to Sep 2016 were retrieved and screened from the bio-databases and then essential data were extracted for data analysis. Next, subgroup analyses on ethnicity, source of controls, sample size, and genotyping method were also carried out...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27901479/the-association-between-the-tp53-arg72pro-polymorphism-and-colorectal-cancer-an-updated-meta-analysis-based-on-32-studies
#14
Xin Tian, Shundong Dai, Jing Sun, Shenyi Jiang, Youhong Jiang
Several previous studies evaluated the association between the Arg72Pro (rs1042522) polymorphism in the TP53 tumor suppressor gene and colorectal cancer (CRC). However, the results are conflicting. This meta-analysis aimed to shed new light on the precise association between TP53 variants and CRC. We analyzed 32 published case-control studies involving 8,586 cases and 10,275 controls using crude odd ratios (ORs) with 95% confidence intervals (CIs). The meta-analysis was performed using a fixed-effect or random-effects model, as appropriate...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27901128/heterozygote-advantage-of-the-rs3794624-polymorphism-in-cyba-for-resistance-to-tuberculosis-in-two-chinese-populations
#15
Qianqian Liu, Shouquan Wu, Miao Xue, Andrew J Sandford, Jingcan Wu, Yu Wang, Guo Chen, Chuanmin Tao, Yin Tang, Yulin Feng, Jun Luo, Jian-Qing He
Phagocyte Nicotinamide Adenine Dinucleotide Phosphate (NADPH) oxidase complex is a key enzyme that catalyzes the production of reactive oxygen species, which mediate oxygen-dependent killing of microorganisms, such as Mycobacterium tuberculosis. P22phox, encoded by CYBA, is the key regulatory subunit of NADPH oxidase. Our study aimed to investigate the association of CYBA polymorphisms with susceptibility to tuberculosis. Three SNPs (rs9932581, rs3794624 and rs4673) were genotyped in the discovery cohort composed of Chinese Han individuals...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27900918/modification-of-gellan-gum-films-by-halloysite-physicochemical-evaluation-and-drug-permeation-properties
#16
Duangkamon Sakloetsakun, Thaned Pongjanyakul
The aims of this study were to determine the potential of gellan gum (GG) and halloysite (HS) dispersions at different mixing ratios and investigate the potential of GG-HS dispersions in film formation. To this end, the dispersions and films were characterized. The dispersions formed films with large particles ranging from 3-4 µm in size, with a zeta potential of approximately -35 mV. The GG-HS films were fabricated using a solvent-casting technique, which generated films with a white opaque appearance and rough surface...
November 30, 2016: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/27900880/associations-of-nicotinamide-n-methyltransferase-gene-single-nucleotide-polymorphisms-with-sport-performance-and-relative-maximal-oxygen-uptake
#17
Jiang-Hua Li, Wei Chen, Xiao-Juan Zhu, Ya-Jun Lin, Li-Qiang Qiu, Can-Xin Cai, Ya-Hui Wang, Qun Xiong, Fei Chen, Li-Hui Chen
To observe the associations between single nucleotide polymorphisms (SNPs) of nicotinamide N-methyltransferase (NNMT) gene and sport performance and to analyse genotype associations of the associated SNPs with sport performance and relative maximal oxygen uptake ([Formula: see text]). Participants were selected from 685 Chinese Han male college students. The completion times of a 1000-m run and a 50-m run were used to reflect sport performance, respectively. Nineteen tagSNPs were genotyped with Polymerase chain reaction-ligase detection reaction...
November 30, 2016: Journal of Sports Sciences
https://www.readbyqxmd.com/read/27900301/association-of-acl-tears-and-single-nucleotide-polymorphisms-in-the-collagen-12-a1-gene-in-the-indian-population-a-preliminary-case-control-study
#18
Rakesh John, Sharad Prabhakar, Mandeep Singh Dhillon, Akshay Anand, Gillipsie Minhas
BACKGROUND: Genetic predisposition to ACL tears has received tremendous interest in the past few years with many SNPs of different genes being linked to ACL tear. STUDY OBJECTIVES: To examine if specific sequence variants in COL12A1 gene are associated with ACL tears in Indian population. STUDY DESIGN: Case-control study. MATERIALS AND METHODS: 50 patients with surgically diagnosed ACL tear and 52 healthy, age-matched controls without any ligament/tendon injuries were genotyped for rs970547 and rs240736 SNPs using real time PCR method...
April 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/27900291/elastin-a-possible-genetic-biomarker-for-more-severe-ligament-injuries-in-elite-soccer-a-pilot-study
#19
Rosa Artells, Ricard Pruna, Alexandre Dellal, Nicola Maffulli
BACKGROUND: The study of new genetic biomarkers in genes related to connective tissue repair and regeneration may help to identify individuals with greater predisposition to injury, who may benefit from targeted preventive measures, and those who require longer recovery time following a muscle, ligament or tendon injury. The present study investigated whether single nucleotide polymorphisms of the Elastin gene could be related to MCL injury. METHODS: 60 top class football players were studied to identify single nucleotide polymorphisms for the Elastin (ELN) gene using Allelic Discrimination analysis...
April 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/27899942/adiponectin-receptor-1-and-small-ubiquitin-like-modifier-4-polymorphisms-are-associated-with-risk-of-coronary-artery-disease-without-diabetes
#20
Hong Li, Ze Yang, Lian-Mei Pu, Xiang Li, Yang Ruan, Fan Yang, Shuai Meng, Duo Yang, Wei Yao, Hao Fu, Feng Zhang, Ze-Ning Jin
BACKGROUND: The genes encoding adiponectin receptor 1 (ADIPOR1) and small ubiquitin-like modifier 4 (SUMO4) have been linked to anti-atherogenic effects, but little is known about whether polymorphisms in the two genes, acting separately or interacting, affect risk of coronary artery disease (CAD) without diabetes. METHODS: We genotyped 200 CAD patients without diabetes and 200 controls without CAD or diabetes at three single-nucleotide polymorphisms (SNPs) in ADIPOR1 and one SNP in SUMO4, which were chosen based on previous studies...
September 2016: Journal of Geriatric Cardiology: JGC
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