keyword
MENU ▼
Read by QxMD icon Read
search

gg

keyword
https://www.readbyqxmd.com/read/29334679/the-il20-genetic-polymorphism-is-associated-with-altered-clinical-outcome-in-septic-shock
#1
Taka-Aki Nakada, Petch Wacharasint, James A Russell, John H Boyd, Emiri Nakada, Simone A Thair, Tadanaga Shimada, Keith R Walley
BACKGROUND: The IL10 family of genes includes crucial immune regulators. We tested the hypothesis that single nucleotide polymorphisms (SNPs) in IL10, IL19, IL20, and IL24 of the IL10 family gene cluster alter the clinical outcome of septic shock. METHODS: Patients with septic shock (n = 1,193) were genotyped for 13 tag SNPs of IL10, IL19, IL20, and IL24. IL20 gene expression was measured in genotyped lymphoblastoid cells in vitro. Cardiac surgical ICU patients (n = 981) were genotyped for IL20 rs2981573 A/G...
January 16, 2018: Journal of Innate Immunity
https://www.readbyqxmd.com/read/29332342/study-on-the-association-between-pi3k-akt-mtor-signaling-pathway-gene-polymorphism-and-susceptibility-to-gastric-cancer
#2
Lei Qi, Kewen Sun, Yun Zhuang, Jing Yang, Jianping Chen
PURPOSE: Excessive activation of PI3K/AKT/mTOR signaling pathway is one of the most common changes in human cancers, and single nucleotide polymorphisms (SNPs) existing in its functional region can affect the occurrence process of a variety of cancers. This study aimed to screen out the SNPs associated with susceptibility to gastric cancer in the PI3K/AKT/mT0R signaling pathway. METHODS: In this case-control study, the tagging SNPs in the promoter region5'-UTR, exon region or 3'-UTR of PIK3CA, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3 and mTOR genes were screened out...
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29331485/impact-of-9p21-3-region-and-atherosclerosis-related-genes-variants-on-long-term-recurrent-hard-cardiac-events-after-a-myocardial-infarction
#3
German J Osmak, Boris V Titov, Natalia A Matveeva, Vitalina V Bashinskaya, Roman M Shakhnovich, Tatiana S Sukhinina, Nino G Kukava, Mikhail Ya Ruda, Olga O Favorova
Atherosclerotic coronary artery disease (CAD) and myocardial infarction (MI) as its most severe clinical complication remain the leading causes of mortality in the majority of countries. Despite the progress in the treatment of MI, quite often the patients, after the first-time MI, develop subsequently a variety of adverse cardiovascular events. In this retrospective study we evaluated the contribution of allelic variations in 9p21.3 locus and in 21 atherogenesis-related genes to the development of hard cardiac events in a cohort of patients of Russian ethnicity after the first acute MI during long-term follow-up (7-10 years)...
January 10, 2018: Gene
https://www.readbyqxmd.com/read/29330562/influence-of-genetic-polymorphisms-of-il23r-stat3-il12b-and-stat4-on-the-risk-of-aplastic-anemia-and-the-effect-of-immunosuppressive-therapy
#4
Li Zhao, Huanling Zhu, Bing Han, Lixin Wang, Yuming Sun, Xiaojun Lu, Chunyan Huang, Bin Tan, Chunxia Chen, Li Qin
Studies have suggested that IL-23/STAT3 and IL-12/STAT4 signaling pathways associate with aplastic anemia (AA) occurrence. Polymorphisms in pathway-related genes may contribute to AA risk. In the current study, we investigated the association between polymorphisms in genes of IL23R, STAT3, IL12B, and STAT4 and occurrence, severity, and immunosuppressive outcome of AA in the Han population in southwest China. In the current 164 AA cases and 211 controls study, we found T allele and TT genotype of rs7574865 were more frequent in the cases than that in the controls...
January 12, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29328375/the-role-of-il%C3%A2-16-gene-polymorphisms-in-endometriosis
#5
Michail Matalliotakis, Maria I Zervou, Elias Eliopoulos, Charoula Matalliotaki, Nilufer Rahmioglu, Ioannis Kalogiannidis, Krina Zondervan, Demetrios A Spandidos, Ioannis Matalliotakis, George N Goulielmos
Endometriosis is one of the most common gynecological diseases affecting up to 10% of the female population of childbearing age and a major cause of pain and infertility. It is influenced by multiple genetic, epigenetic and environmental factors. Interleukin‑16 (IL‑16) is a proinflammatory cytokine playing a pivotal role in many inflammatory and autoimmune diseases as well as in the pathogenesis of endometriosis. The aim of the present study was to evaluate the association of two IL‑16 gene single nucleotide polymorphisms (SNPs), rs4072111 and rs11556218, with the risk of endometriosis in women from Greece as well as to gain insight about the structural consequences of these two exonic SNPs regarding development of the disease...
January 9, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29325772/the-association-of-snp276g-t-at-adiponectin-gene-with-insulin-resistance-and-circulating-adiponectin-in-response-to-two-different-hypocaloric-diets
#6
Daniel Antonio de Luis, Olatz Izaola, David Primo, R Aller, A Ortola, E Gómez, J J Lopez
BACKGROUND: Several adiponectin gene (ADIPOQ) single nucleotide polymorphisms (SNPS) have been related with adiponectin levels and risk for obesity. OBJECTIVE: The aim of our study was to analyze the effect of rs1501299 ADIPOQ gene polymorphism and dietary intake on total adiponectin levels and insulin resistance after two hypocaloric diets in obese subjects. MATERIAL AND METHODS: A Caucasian population of 284 obese patients was enrolled in a randomized clinical trial with two hypocaloric diets (I: moderate carbohydrates vs II: low fat)...
January 8, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29323258/association-between-arsenic-metabolism-gene-polymorphisms-and-arsenic-induced-skin-lesions-in-individuals-exposed-to-high-dose-inorganic-arsenic-in-northwest-china
#7
Lanrong Luo, Yuanyuan Li, Yanhui Gao, Lijun Zhao, Hongqi Feng, Wei Wei, Chuanying Qiu, Qian He, Yanting Zhang, Songbo Fu, Dianjun Sun
Individuals in a given environment contaminated with arsenic have different susceptibilities to disease, which may be related to arsenic metabolism, age, gender, genetics and other factors. This study recruited 850 subjects, including 331 cases and 519 controls, from populations exposed to high levels of arsenic in drinking water in northwest China. Genotypes were determined using a custom-by-design 48-Plex SNPscanTM kit. The results indicated that subjects who carried at least one C allele for GSTO1 rs11191979 polymorphism, at least one A allele for GSTO1 rs2164624, at least one A allele for GSTO1 rs4925, the AG genotype for GSTO2 rs156697, the AG genotype or at least one G allele for GSTO2 rs2297235 or the GG genotype or at least one G allele for PNP rs3790064 had an increased risk of arsenic-related skin lesions...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29323248/exploring-the-utility-of-alcohol-flushing-as-an-instrumental-variable-for-alcohol-intake-in-koreans
#8
Yoonsu Cho, Soyoung Kwak, Sarah J Lewis, Kaitlin H Wade, Caroline L Relton, George Davey Smith, Min-Jeong Shin
Previous studies have indicated an association of higher alcohol intake with cardiovascular disease and related traits, but causation has not been definitively established. In this study, the causal effect of alcohol intake on hypertension in 2,011 men and women from the Ansan-Ansung cohort was estimated using an instrumental variable (IV) approach, with both a phenotypic and genotypic instrument for alcohol intake: alcohol flushing and the rs671 genotype (in the alcohol dehydrogenase 2 [ALDH2] gene), respectively...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29322800/usf1-gene-polymorphisms-may-associate-with-the-efficacy-and-safety-of-chemotherapy-based-on-paclitaxel-and-prognosis-in-the-treatment-of-ovarian-cancer
#9
H Ye, X J Liu, Y Hui, Y H Liang, C H Li, Q Wan
This study was supposed to investigate the correlation between the functional single nucleotide polymorphisms (SNPs) (rs2516839 and rs3737787) in USF1 gene and the efficacy and safety of paclitaxel-based chemotherapy and prognosis in the treatment of ovarian cancer (OC). In total 100 OC patients were selected and divided into the sensitive group and the resistantgroup according to the tumor response to paclitaxel-based chemotherapy after surgery, and the incidence of observed and recorded toxic reaction. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was applied to test the polymorphisms of rs2516839 and rs3737787 in USF1 gene after extraction of DNA...
2018: Neoplasma
https://www.readbyqxmd.com/read/29321381/association-between-genetic-polymorphism-and-levothyroxine-bioavailability-in-hypothyroid-patients
#10
Merve Arici, Ezgi Oztas, Fatih Yanar, Nihat Aksakal, Beyza Ozcinar, Gul Ozhan
Thyroid hormones play a vital role in the human body for growth and differentiation, regulation of energy metabolism, and physiological function. Hypothyroidism is a common endocrine disorder, which generally results from diminished normal circulating concentrations of serum thyroxine (fT4) and triiodothyronine (fT3). The primary choice in hypothyroidism treatment is oral administration of levothyroxine (L-T4), a synthetic T4 hormone, as approximately 100-125 μg/day. Generally, dose adjustment is made by trial and error approach...
January 11, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29318930/effect-of-genetic-polymorphisms-in-srebf-scap-pathway-on-therapeutic-response-to-rosuvastatin-in-saudi-metabolic-syndrome-patients
#11
Misbahuddin Mohd Rafeeq, Hamed Said Habib, Hussam Aly Sayed Murad, Mamdouh Abdullah Gari, Zohair Jamil Gazzaz
AIM: Genetic variants contribute to statins' therapeutic variability. SREBF-SCAP pathway is a key player in lipid homeostasis. Hence, effect of SREBF-SCAP polymorphisms on therapeutic response was studied. PATIENTS & METHODS: Metabolic syndrome patients of either sex were prescribed rosuvastatin 10 mg for 24 weeks. Clinical, anthropometric and lipid measurements were done before and after treatment. Genotyping was done by pyrosequencing. RESULTS & CONCLUSION: No associations of SCAP and SREBF-1a genotypes with baseline lipids but significant associations with lipid reductions were observed...
January 10, 2018: Pharmacogenomics
https://www.readbyqxmd.com/read/29317837/the-rnasel-1385g-a-polymorphism-is-associated-with-risk-of-prostate-cancer-in-africans
#12
REVIEW
Xiaolei Liu, Dejie Zheng, Guowei Lu, Baohong Yang
The RNASEL -1385G/A (rs486907) variant has been reported to be associated with increased risk of prostate cancer. However, these associations are not consistent among studies. To address this issue, we performed a meta-analysis to evaluate the association between RNASEL -1385G/A polymorphism and prostate cancer risk. The PubMed, Embase, and Web of Science databases were searched for relevant papers published in the past 20 years from 1997 to 2017. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of associations...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29317318/association-study-of-mir-100-mir-124-1-mir-218-2-mir-301b-mir-605-and-mir-4293-polymorphisms-and-the-risk-of-breast-cancer-in-a-sample-of-iranian-population
#13
Hiva Danesh, Mohammad Hashemi, Fatemeh Bizhani, Seyed Mehdi Hashemi, Gholamreza Bahari
MicroRNAs (miRNAs) regulate genes expression by directly binding to the 3' untranslated region (3'UTR) of specific target mRNAs. Single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) are proposed to be important in the development of breast cancer (BC). In the present study, we conducted a case-control study with 266 BCE patients and 288 control women to examine the possible association of miRNAs polymorphisms (miR-100 rs1834306, miR-124-1 rs531564, miR-218-2 rs11134527, miR-301b rs384262, miR-605 rs2043556, and miR-4293 rs12220909) with BC susceptibility...
January 6, 2018: Gene
https://www.readbyqxmd.com/read/29317215/influence-of-cytokine-gene-polymorphism-on-the-risk-of-rheumatic-heart-disease-a-meta-analysis
#14
Mansi Bhatt, Surendra Kumar, Mohammad Haris Siddiqui, Naveen Garg, Balraj Mittal
RHD is an inflammatory disease resulting from interactive immune, genetic, and environmental factors. Various, epidemiological studies have shown the association of genetic variants of cytokine genes with a predisposition to RHD. However, the results from different populations are inconsistent. Therefore, we carried out a meta- analysis of twenty-three published case-control studies and the results indicated that TGF-β1 +869 T/C (T vs. C: OR = 7.68, 95% CI = 1.62-36.50; TT + CT vs. CC OR = 1...
January 6, 2018: Immunology Letters
https://www.readbyqxmd.com/read/29315792/association-between-smad3-gene-rs12901499-polymorphism-and-knee-osteoarthritis-in-a-chinese-population
#15
Li Zhang, Limin Zhang, Haiqin Zhang, Wenjun Wang, You Zhao
BACKGROUND: Many studies have revealed that transforming growth factor-beta (TGF-β) signals play important roles in maintaining normal status of articular cartilage in human osteoarthritis (OA). However, SMAD3 had inhibitory effect on TGF-β-induced chondrocyte maturation. METHOD: To evaluate the association of SMAD3 genetic variants with the risk of knee OA, we conducted this hospital-based case-control study involving 350 knee patients with OA and 400 controls in a Chinese population...
January 8, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29313754/adipoq-45t%C3%A2-g-polymorphism-food-ingestion-and-metabolic-syndrome-in-elderly-persons
#16
Vanessa R Retamoso, Patrícia Maurer, Lyana B Feijóo, Graziela M S Tavares, Vanusa Manfredini, Jacqueline C E Piccoli
INTRODUCTION: The current nutritional transition process contributes further to accelerate the onset of metabolic disorders, as do a number of environmental factors that lead to the diagnosis of chronic diseases, as a diet of low nutritional value, is possibly related to the incidence of metabolic syndrome. In addition to these factors, metabolic syndrome may also be related to genetic factors, the ADIPOQ + 45T> G polymorphism has been associated with serum adiponectin levels, insulin sensitivity, and obesity, which affects adiponectin levels act as protective factor for cardiovascular disease...
January 9, 2018: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29313175/a-biomolecular-network-driven-proteinic-interaction-in-hcv-clearance
#17
Pratichi Singh, Febin Prabhu Dass J
Hepatitis C virus infection causes chronic liver disease that leads to cancer-related mortality. Presently around 30% of the HCV (infected) affected population get rid of the infection through spontaneous disease clearance. This phenomenon is conducted by a set of reported immune candidate genes. Hence, this study focuses only on these immune-response related genes with aid of network approach, where the idea is to disseminate the network for better understanding of key functional genes and their transcription control activity...
January 8, 2018: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29313136/klotho-g-395a-gene-polymorphism-impact-on-progression-of-end-stage-renal-disease-and-development-of-cardiovascular-complications-in-children-on-dialysis
#18
Eman A Elghoroury, Fatina I Fadel, Manal F Elshamaa, Dina Kandil, Doaa M Salah, Marwa M El-Sonbaty, Hebatallah Farouk, Mona Raafat, Soha Nasr
BACKGROUND: Klotho G-395-A gene polymorphism may impact children with end-stage renal disease (ESRD). We investigated the relevance of Klotho G-395-A on ESRD development and progression, and its relationship with evolution of cardiovascular complications in pediatric dialysis patients. METHODS: Fifty-five children with chronic kidney disease (CKD) and seventy healthy children were genotyped for Klotho G-395A. RESULTS: Incidence of GA/AA genotypes and A allele were higher in ESRD patients compared with controls (54...
January 8, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29312594/investigation-of-tcf7l2-lep-and-lepr-polymorphisms-with-esophageal-squamous-cell-carcinomas
#19
Hao Qiu, Xunting Lin, Weifeng Tang, Chao Liu, Yu Chen, Hao Ding, Mingqiang Kang, Shuchen Chen
Single nucleotide polymorphisms (SNPs) in energy metabolism related gene may be key agents in the development of human malignancies. In this study, we aimed to examine the association of transcription factor 7-like 2, Leptin (LEP) and LEP receptor (LEPR) polymorphisms with esophageal squamous cell carcinoma (ESCC). A total of 507 ESCC cases and 1,496 controls were enrolled. We found that LEPR rs6588147 AA genotype was associated with ESCC risk (AA vs. GG/GA: adjusted OR=1.90, 95%CI=1.00-3.61, P=0.049). In the stratified analyses, LEPR rs6588147 G>A polymorphism increased the risk of ESCC (<63 years subgroup: AA vs...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29310863/synthesis-and-biological-evaluation-of-cyclopeptide-gg-8-6-and-its-analogues-as-anti-hepatocellular-carcinoma-agents
#20
Jie-Tao Chen, Ru Ma, Shi-Chang Sun, Xiao-Feng Zhu, Xiao-Li Xu, Qing Mu
GG-8-6, cyclo-(Val-Leu-Pro-Ile-Leu-Leu-Leu-Val-Leu, compound 1), and its twelve analogues (compound 2-13) were synthesized based on the lead compound Grifficyclocin B, a cyclic peptide with anti-tumor activity which was isolated from the plants of Goniothalamus species (Annonaceae). The bioassay results showed that these synthetic cyclopeptides exhibited different extent of cytotoxicity against human hepatocellular carcinoma cell lines. Among them, GG-8-6 (1) was the most active compound with IC50 values of 6...
December 20, 2017: Bioorganic & Medicinal Chemistry
keyword
keyword
21071
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"