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https://www.readbyqxmd.com/read/28945042/-effect-of-compound-longmaining-decoction-with-different-combinations-on-intestinal-absorption-of-puerarin
#1
Xi-Hui Bai, Shi-Yu Liu, Jing Wang, Chang-Li Wang, Xiao Song
To study the effects of compound Longmaining(FFLMN) with different combinations on the intestinal absorption of puerarin. The rat single pass intestinal perfusion model was adopted, and the concentration of puerarin in intestinal samples was determined by HPLC. The effects of different combination groups on the absorption of puerarin in duodenum, jejunum, ileum and colon were investigated. The combined drugs were GG(Puerariae Lobatae Radix), GG-CSL (Puerariae Lobatae Radix compared with Dioscoreae Nipponicae Rhizoma), GG-CX(Puerariae Lobatae Radix compared with Chuanxiong Rhizoma) and FFLMN (compound Longmaining)...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28942034/agxt2-rs37369-polymorphism-predicts-the-renal-function-in-patients-with-chronic-heart-failure
#2
Xiao-Lei Hu, Wen-Jing Zeng, Mu-Peng Li, Yong-Long Yang, Da-Bin Kuang, He Li, Yan-Jiao Zhang, Chun Jiang, Li-Ming Peng, Hong Qi, Ke Zhang, Xiao-Ping Chen
Patients with chronic heart failure (CHF) are often accompanied with varying degrees of renal diseases. The purpose of this study was to identify rs37369 polymorphism of AGXT2 specific to the renal function of CHF patients. A total of 1012 southern Chinese participants, including 487 CHF patients without renal diseases and 525 healthy volunteers, were recruited for this study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to determine the genotypes of AGXT2 rs37369 polymorphism...
September 20, 2017: Gene
https://www.readbyqxmd.com/read/28941965/gestational-respiratory-infections-interacting-with-offspring-hla-and-ctla-4-modifies-incident-%C3%AE-cell-autoantibodies
#3
Kristian F Lynch, Hye-Seung Lee, Carina Törn, Kendra Vehik, Jeffrey P Krischer, Helena Elding Larsson, Michael J Haller, William A Hagopian, Marian J Rewers, Jin-Xiong She, Olli G Simell, Jorma Toppari, Anette-G Ziegler, Beena Akolkar, Heikki Hyöty, Ezio Bonifacio, Åke Lernmark
β-cell autoantibodies against insulin (IAA), GAD65 (GADA) and IA-2 (IA-2A) precede onset of childhood type 1 diabetes (T1D). Incidence of the first appearing β-cell autoantibodies peaks at a young age and is patterned by T1D-associated genes, suggesting an early environmental influence. Here, we tested if gestational infections and interactions with child's human leukocyte antigen (HLA) and non-HLA genes affected the appearance of the first β-cell autoantibody. Singletons of mothers without diabetes (n = 7472) with T1D-associated HLA-DR-DQ genotypes were prospectively followed quarterly through the first 4 years of life, then semiannually until age 6 years, using standardized autoantibody analyses...
September 20, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28941610/scavenger-receptor-lox1-genotype-predicts-coronary-artery-disease-in-patients-with-familial-hypercholesterolemia
#4
Martine Paquette, Robert Dufour, Alexis Baass
BACKGROUND: Familial hypercholesterolemia (FH) is a monogenic disease associated with elevated low-density lipoprotein (LDL) cholesterol and oxidized LDL (oxLDL) leading to premature cardiovascular disease. Lectin-like oxLDL receptor-1 (LOX1) is one of the major contributors of oxLDL uptake and degradation in macrophages, which leads to foam cell formation and the development of atherosclerosis. This study investigated the effect of the rs11053646 genotype of the oxidized low-density lipoprotein receptor 1 (OLR1) gene on coronary artery disease (CAD) risk in a cohort of FH patients...
October 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28941036/association-of-donor-sumo4-rs237025-genetic-variant-with-tacrolimus-elimination-in-the-early-period-after-liver-transplantation
#5
Tao Zhang, Yuan Liu, Rong Zeng, Qi Ling, Peihao Wen, Junwei Fan, Zhihai Peng
BACKGROUNDS & AIMS: Individualized tacrolimus treatment can improve drug safety and efficacy. In this study, we aimed to investigate the association of donor and recipient small ubiquitin-like modifier 4 (SUMO4) rs237025 polymorphisms with tacrolimus elimination and the potential mechanism. METHODS: A total of 297 liver transplant patients were enrolled in the study. CYP3A5 rs776746 and SUMO4 rs237025 were genotyped using TaqMan SNPs assays. The activity of nuclear factor-kB (NF-kB) was evaluated by luciferase assay...
September 21, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28940947/a-single-nucleotide-polymorphism-of-dna-methyltransferase-3b-gene-is-a-risk-factor-for-recurrent-spontaneous-abortion
#6
Anita Barišić, Nina Pereza, Alenka Hodžić, Saša Ostojić, Borut Peterlin
PROBLEM: Aberrant DNA methylation has been suggested as a potential cause of recurrent spontaneous abortion (RSA). Considering the growing evidence on the important roles of DNA methylation in gametogenesis and early pregnancy, we investigated the potential association of DNA methyltransferase gene polymorphisms (DNMT1 rs2228611, DNMT3A rs1550117, DNMT3B rs1569686) with RSA in Slovenian reproductive couples. METHOD OF STUDY: A total of 146 couples with ≥3 consecutive spontaneous abortions and 149 control women and men with ≥2 normal pregnancies were included...
September 20, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28940489/polymorphisms-in-homologous-recombination-repair-genes-and-the-risk-and-survival-of-breast-cancer
#7
Yu-Huang Liao, Jun-Ting Ren, Wei Zhang, Zheng-Zheng Zhang, Ying Lin, Feng-Xi Su, Wei-Hua Jia, Lu-Ying Tang, Ze-Fang Ren
BACKGROUND: IgA antibody of Epstein-Barr virus (EBV) was found to associate with breast cancer, while the IgA positivity was related to a series of genetic markers in the genes of homologous recombination repair system (HRRs). We then assessed the associations of the polymorphisms in HRR genes with the risk and survival of breast cancer. MATERIALS AND METHODS: A case-control study was conducted with 1551 BC cases and 1605 age-matched healthy controls between October 2008 and March 2012 in the Guangzhou Breast Cancer Study (GZBCS), China, and the case population were followed up until January 31 2016...
September 23, 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/28939338/comparison-of-the-role-of-hhip-snps-in-susceptibility-to-chronic-obstructive-pulmonary-disease-between-chinese-han-and-mongolian-populations
#8
Guihua Xu, Xiaoyu Gao, Sainan Zhang, Yan Wang, Mingjing Ding, Wenyan Liu, Jie Shen, Dejun Sun
The contribution of risk alleles to chronic obstructive pulmonary disease (COPD) may vary between populations. This study aimed to investigate the role of single nucleotide polymorphisms (SNPs) in HHIP on COPD susceptibility in the Chinese Mongolian and Han populations from Inner Mongolia autonomous region. In this case-control study, five SNPs in HHIP gene were detected in 700 COPD patients (350 Chinese Han and 350 Chinese Mongolian) and 700 healthy controls (350 Chinese Han and 350 Chinese Mongolian). The genotype, the association with COPD, and the differences between Chinese Han and Mongolian populations were evaluated using the chi-squared (χ(2)) test, genetic models, and logistic analysis...
September 19, 2017: Gene
https://www.readbyqxmd.com/read/28938685/a-case-control-study-of-the-association-between-the-egfr-gene-and-glioma-risk-in-a-chinese-han-population
#9
Mengdan Yan, Jingjie Li, Na He, Xugang Shi, Shuli Du, Bin Li, Tianbo Jin
The Epidermal Growth Factor Receptor gene has been reported to be involved in the progression of gliomas which is one of the deadliest primary brain tumors in humans. To determine potential association between EGFR and glioma risk, we performed a case-control study with 394 glioma patients and 298 cancer-free controls in which captured a total of 8 tag single nucleotide polymorphisms of EGFR gene from Xi'an, China. SPSS 19.0 statistical packages, χ(2) test, genetic model analysis and SHEsis software platform were analyzed s the variants in EGFR gene associations with glioma risk...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938640/association-of-two-obesity-related-gene-polymorphisms-lepg2548a-rs7799039-and-leprq223r-rs1137101-with-the-risk-of-breast-cancer
#10
Hui Luan, Hong Zhang, Ying Li, Ping Wang, Lifei Cao, Honglan Ma, Qing Cui, Gang Tian
Many studies have been performed to investigate the correlation of leptin (LEP) and leptin receptor (LEPR) polymorphisms with breast cancer (BC) risk, however the results are inconclusive. To obtain a more precise estimation, we conducted this meta-analysis. We searched PubMed, EMBASE, and Web of Science databases to identify qualified studies. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the association. Eight eligible studies (2,124 cases and 5,476 controls) for LEP G2548A (rs7799039) polymorphism, and thirteen studies (5,282 cases and 6,140 controls) for LEPR Q223R (rs1137101) polymorphism were included in our study...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938556/abcg2-and-ncf4-polymorphisms-are-associated-with-clinical-outcomes-in-diffuse-large-b-cell-lymphoma-patients-treated-with-r-chop
#11
Duo Liu, Nan Wu, Haiming Sun, Mei Dong, Tianzhu Guo, Peng Chi, Guofu Li, Donglin Sun, Yan Jin
The impact of pharmacogenetics on predicting survival in diffuse large B-cell lymphoma (DLBCL) remains unclear. We tested 337 DLBCL patients treated with rituximab-cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) for 9 single nucleotide polymorphisms from 6 genes (CD20, FCGR2A, NAD(P)H, ABCC2, ABCG2 and CYP3A5). Patients who carried the NCF4 rs1883112 GG genotype showed significantly shorter progression-free survival (PFS) (P = 0.023) and event-free survival (EFS) (P < 0.001) comparing with A allele...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938222/inter-hemispherical-asymmetry-in-default-mode-functional-connectivity-and-baiap2-gene-are-associated-with-anger-expression-in-adhd-adults
#12
R Hasler, M G Preti, D E Meskaldji, J Prados, W Adouan, C Rodriguez, S Toma, N Hiller, T Ismaili, J Hofmeister, I Sinanaj, P Baud, S Haller, P Giannakopoulos, S Schwartz, N Perroud, D Van De Ville
Attention deficit hyperactivity disorder (ADHD) is accompanied by resting-state alterations, including abnormal activity, connectivity and asymmetry of the default-mode network (DMN). Concurrently, recent studies suggested a link between ADHD and the presence of polymorphisms within the gene BAIAP2 (i.e., brain-specific angiogenesis inhibitor 1-associated protein 2), known to be differentially expressed in brain hemispheres. The clinical and neuroimaging correlates of this polymorphism are still unknown. We investigated the association between BAIAP2 polymorphisms and DMN functional connectivity (FC) asymmetry as well as behavioral measures in ADHD adults...
September 12, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28936849/-effect-of-flavonoids-from-abelmoschus-manihot-on-proliferation-differentiation-of-3t3-l1-preadipocyte-and-insulin-resistance
#13
Hong-Die Cai, Shu-Lan Su, Sheng Guo, Yue Zhu, Da-Wei Qian, Wei-Wei Tao, Jin-Ao Duan
Abelmoschus manihot was rich in flavonoids, which has been reported the activity on protecting angiocarpy and improving renal function. This study aimed to explore the action mechanism of five flavonoids from A. manihot on how to ameliorating insulin resistance through the regulation of the glucose and expression of PPARγ, C/EBPα, SREBP-1, resistin, visfatin, adiponectin in 3T3-L1 adipocytes. After the 3T3-L1 preadipocytes were differentiated into mature adipocytes, insulin resistance model was built. Insulin resistance adipocytes were treated with 5, 100 μmol•L⁻¹ quercetin, isoquercitrin, hyperoside, quercitrin-3'-O-glucoside, gossypetin-8-O-β-glucoside...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28935761/impact-of-tnf-308-g-a-rs1800629-gene-polymorphism-in-modulation-of-leprosy-risk-a-reappraise-meta-analysis-of-14-case-control-studies
#14
Mohammed Y Areeshi, Raju K Mandal, Sajad Ahmad Dar, Arshad Jawed, Mohd Wahid, Mohtashim Lohani, Aditya K Panda, B N Mishra, Naseem Akhter, Shafiul Haque
Purpose: Earlier studies have shown that tumor necrosis factor ( TNF ) -308 G>A (rs1800629) gene polymorphism is implicated in the susceptibility to leprosy, but results were inconsistent. Methods: A meta-analysis of 14 studies involving 3327 leprosy cases and 3203 controls was performed to appraise the association of TNF -308 G>A polymorphism with leprosy using MEDLINE (PUBMED), EMBASE, and Google Scholar web-databases. Results: Overall, no significant association was observed in allelic (A vs. G: p=0...
September 21, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28934792/effects-of-pulsed-versus-conventional-versus-combined-radiofrequency-for-the-treatment-of-trigeminal-neuralgia-a-prospective-study
#15
Abdelraheem Elawamy, Esam Eldein Mohamed Abdalla, Ghaydaa A Shehata
BACKGROUND: During radiofrequency bursts of energy are applied to nervous tissue. The clinical advantages of this treatment remain unclear. OBJECTIVES: We compared the effectiveness and pain relief for idiopathic trigeminal neuralgia (TN) after continuous radiofrequency (CRF), pulsed radiofrequency (PRF), and combined continuous and pulsed radiofrequency (CCPRF) treatment of the Gasserian ganglion (GG). STUDY DESIGN: We conducted a randomized prospective study...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28932705/probiotics-for-the-treatment-of-atopic-dermatitis-in-children-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#16
Ruixue Huang, Huacheng Ning, Minxue Shen, Jie Li, Jianglin Zhang, Xiang Chen
Objective: Atopic dermatitis (AD) is a prevalent, burdensome, and psychologically important pediatric concern. Probiotics have been suggested as a treatment for AD. Some reports have explored this topic; however, the utility of probiotics for AD remains to be firmly established. Methods: To assess the effects of probiotics on AD in children, the PubMed/Medline, Cochrane Library Scopus, and OVID databases were searched for reports published in the English language. Results: Thirteen studies were identified. Significantly higher SCORAD values favoring probiotics over controls were observed (mean difference [MD], -3...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28931965/polymorphisms-in-lncrna-ptenp1-and-the-risk-of-gastric-cancer-in-a-chinese-population
#17
Yugang Ge, Yu He, Mingkun Jiang, Dakui Luo, Xiangkun Huan, Weizhi Wang, Diancai Zhang, Li Yang, Jundong Zhou
Long noncoding RNA (lncRNA) phosphatase and tensin homolog pseudogene 1 (PTENP1) is significantly downregulated in gastric cancer (GC), playing critical roles in GC progression. However, the association between PTENP1 genetic variants and GC risk has not yet been reported. Using TaqMan technology, three lncRNA PTENP1 tag single nucleotide polymorphisms (tagSNPs) (rs7853346 C>G, rs865005 C>T, and rs10971638 G>A) were genotyped in 768 GC patients and 768 cancer-free controls in a Chinese population. We found that subjects with rs7853346 G allele had a remarkably decreased risk of GC, compared with those carrying C allele (P = 0...
2017: Disease Markers
https://www.readbyqxmd.com/read/28930887/genetic-variant-near-plxdc2-influences-the-risk-of-primary-open-angle-glaucoma-by-increasing-intraocular-pressure-in-the-japanese-population
#18
Fumihiko Mabuchi, Nakako Mabuchi, Mitsuko Takamoto, Yoichi Sakurada, Seigo Yoneyama, Kenji Kashiwagi, Hiroyuki Iijima, Zentaro Yamagata, Makoto Aihara, Takeshi Iwata, Makoto Araie
PURPOSE: To assess the association between the genetic variants that were previously reported to be associated with primary open-angle glaucoma (POAG) in the Japanese population and the phenotypic features. METHODS: Six hundred sixty-one Japanese patients including 417 patients with POAG (normal tension glaucoma [NTG], n=210; high tension glaucoma [HTG], n=207) and 244 control subjects without glaucoma were analyzed for 3 genetic variants: rs547984 (near gene: ZP4), rs7081455 (PLXDC2), and rs7961953 (TMTC2)...
September 19, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28929635/association-between-interferon-induced-helicase-ifih1-rs1990760-polymorphism-and-seasonal-variation-in-the-onset-of-type-1-diabetes-mellitus-ifih1-polymorphism-and-type-1-diabetes-onset
#19
Ágnes Jermendy, Ildikó Szatmári, Anna Körner, Attila J Szabó, Péter Tóth-Heyn, Róbert Hermann
BACKGROUND: Infections, mostly of viral origin, may contribute to the seasonal variation in the onset of type 1 diabetes mellitus (T1DM). The rs1990760 (A>G, Ala946Thr) polymorphism (GG genotype) of the interferon induced helicase (IFIH1), a virus recognition receptor, confers a modest protection for T1DM. The aim of our study was to evaluate a possible association between this IFIH1 polymorphism and the seasonal variation in the onset of T1DM. MATERIALS AND METHODS: The IFIH1 rs1990760 polymorphism was genotyped in 1055 patients of Central-Eastern European ancestry with T1DM (median age at diagnosis: 8...
September 20, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28929029/association-of-rs1801157-single-nucleotide-polymorphism-of-cxcl12-gene-in-breast-cancer-in-pakistan-and-in-silico-expression-analysis-of-cxcl12-cxcr4-associated-biological-regulatory-network
#20
Samra Khalid, Rumeza Hanif
BACKGROUND: C-X-C chemokine ligand 12 (CXCL12) has important implications in breast cancer (BC) pathogenesis. It is selectively expressed on B and T lymphocytes and is involved in hematopoiesis, thymocyte trafficking, stem cell motility, neovascularization, and tumorigenesis. The single nucleotide polymorphism (SNP) rs1801157 of CXCL12 gene has been found to be associated with higher risk of BC. METHODS: Our study focuses on the genotypic and allelic distribution of SNP (rs1801157; G/A) in Pakistani population as well as its association with the clinico-pathological features...
2017: PeerJ
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