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https://www.readbyqxmd.com/read/28097500/update-on-aspirin-exacerbated-respiratory-disease
#1
REVIEW
Katharine M Woessner
Aspirin-exacerbated respiratory disease (AERD) is an acquired disease characterized by chronic eosinophilic airway inflammation with underlying dysregulation of arachidonic acid metabolism. The purpose of this paper is to review the latest developments in our understanding of the underlying pathophysiology including the role of eosinophils, mast cells, innate lymphoid cells (ILC2), and platelets. Clinical features such as respiratory reactions induced by alcohol, aggressive nasal polyposis, and anosmia will allow for earlier recognition of these patients in clinical practice...
January 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/27993691/effects-of-znso4-induced-peripheral-anosmia-on-zebrafish-behavior-and-physiology
#2
Murilo S Abreu, Ana C V V Giacomini, Rubens Rodriguez, Allan V Kalueff, Leonardo J G Barcellos
Olfaction plays a key role in modulating behavioral and physiological responses of various animal species, including fishes. Olfactory deficits can be induced in fish experimentally, and utilized to examine the role of olfaction in their normal and pathological behaviors. Here, we examine whether experimental anosmia, evoked by ZnSO4 in adult zebrafish can be associated with behavioral and/or physiological responses. We show that experimental ZnSO4-induced anosmia caused acute, but not prolonged, anxiogenic-like effects on zebrafish behavior tested in the novel tank test...
December 16, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27979773/zinc-gluconate-toxicity-in-wild-type-vs-mt1-2-deficient-mice
#3
Heidi Hsieh, Michael C Horwath, Mary Beth Genter
Previous studies have suggested that oral zinc supplementation can help reduce the duration of the common cold; however, the use of intranasal (IN) zinc is strongly associated with anosmia, or the loss of the sense of smell, in humans. Prior studies from this lab showed that upregulation of metallothioneins (MT) is a rapid and robust response to zinc gluconate (ZG). Therefore, we assessed the role of MT in the recovery of nasal epithelial damage resulting from IN zinc administration. The main studies in this investigation used a high dose of ZG (170mM) to ensure ablation of the olfactory mucosa, so that the progression of histological and functional recovery could be assessed...
December 12, 2016: Neurotoxicology
https://www.readbyqxmd.com/read/27968956/a-genetic-marker-of-the-ackr1-gene-is-present-in-patients-with-type-ii-congenital-smell-loss-who-have-type-i-hyposmia-and-hypogeusia
#4
William A Stateman, Alexandra B Knöppel, Willy A Flegel, Robert I Henkin
PURPOSE: Our previous study of Type II congenital smell loss patients revealed a statistically significant lower prevalence of an FY (ACKR1, formerly DARC) haplotype compared to controls. The present study correlates this genetic feature with subgroups of patients defined by specific smell and taste functions. METHODS: Smell and taste function measurements were performed by use of olfactometry and gustometry to define degree of abnormality of smell and taste function...
November 2016: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/27965198/sniffing-out-significant-pee-values-genome-wide-association-study-of-asparagus-anosmia
#5
Sarah C Markt, Elizabeth Nuttall, Constance Turman, Jennifer Sinnott, Eric B Rimm, Ethan Ecsedy, Robert H Unger, Katja Fall, Stephen Finn, Majken K Jensen, Jennifer R Rider, Peter Kraft, Lorelei A Mucci
OBJECTIVE:  To determine the inherited factors associated with the ability to smell asparagus metabolites in urine. DESIGN:  Genome wide association study. SETTING:  Nurses' Health Study and Health Professionals Follow-up Study cohorts. PARTICIPANTS:  6909 men and women of European-American descent with available genetic data from genome wide association studies. MAIN OUTCOME MEASURE:  Participants were characterized as asparagus smellers if they strongly agreed with the prompt "after eating asparagus, you notice a strong characteristic odor in your urine," and anosmic if otherwise...
December 13, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27941181/hypogonadotropic-hypogonadism-in-a-female-patient-with-congenital-arhinia
#6
Janel Darcy Hunter, Melissa Ann Davis, Jennifer Rachel Law
The association of anosmia and congenital hypogonadotropic hypogonadism (CHH) is well described; however, congenital arhinia is a malformation associated with CHH that occurs much more rarely. There have been three reports of male patients with hypogonadism and congenital arhinia in the literature to date. We present the first case of arhinia associated with CHH in a female patient. A 14 years and 8 months female with congenital arhinia presented with delayed puberty. Physical examination and laboratory evaluation were consistent with hypogonadotropic hypogonadism...
January 1, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/27938610/-characteristics-of-postviral-olfactory-disorder
#7
K Y Li, J Liu, W Xiao, Y Wu, Y Y Ren, Y X Wei
Objective: To explore the clinical characteristics of patients with olfactory dysfunction after upper respiratory tract infection. Methods: Through clinical specialist examination and imaging examination, 95 cases of patients with olfactory dysfunction after upper respiratory tract infection were confirmed, 58 cases in anosmia group and 37 cases in hyposmia group. All were performed by a subjective olfactometry (Sniffin'Sticks test) and a subjective taste function tests. The results were statistically analyzed by SPSS 17...
November 7, 2016: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/27914909/benefits-pitfalls-and-risks-of-phytotherapy-in-clinical-practice-in-otorhinolaryngology
#8
O Laccourreye, A Werner, L Laccourreye, P Bonfils
OBJECTIVES: To elucidate the benefits, pitfalls and risks of phytotherapy in the clinical practice of otorhinolaryngology. MATERIAL AND METHODS: The PubMed and Cochrane databases were searched using the following keywords: phytotherapy, phytomedicine, herbs, otology, rhinology, laryngology, otitis, rhinitis, laryngitis and otorhinolaryngology. Seventy-two articles (18 prospective randomized studies, 4 Cochrane analyses, 4 meta-analysis and 15 reviews of the literature) devoted to clinical studies were analyzed...
November 30, 2016: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/27895246/a-case-of-congenital-anosmia
#9
Umesh Vivekananda, Nader Khandanpour, Salah Omer
No abstract text is available yet for this article.
November 29, 2016: Neurology
https://www.readbyqxmd.com/read/27863011/congenital-anosmia-our-experience-of-eleven-patients-with-aplasia-or-hypoplasia-of-the-olfactory-tract
#10
Jason Powell, Ivan Zammit-Maempel, Sean Carrie
Anosmia is present in approximately 1% of the population and can have a significant impact on quality of life (1) . In contrast to acquired anosmia, congenital anosmia is a relatively rare condition characterized by a complete lack of olfactory perception and the aplasia or hypoplasia of the olfactory bulb. Kallmann syndrome (congenital hypogonadotropic hypogonadism and anosmia) is the best known condition assoicated with congenital anosmia (2,3) . Kallmann Syndrome has a prevalence of around 1 in 8000, and is five times more common in men than women (2,3) ...
November 14, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27849216/olfactory-function-and-quality-of-life-after-olfaction-rehabilitation-in-total-laryngectomees
#11
Christiane Gouvêa Dos Santos, Anke Bergmann, Kaliani Lima Coça, Angela Albuquerque Garcia, Tânia Cristina de Oliveira Valente
Purpose: To evaluate the effects of olfaction rehabilitation in the olfactory function and quality of life of total laryngectomized patients. Methods: Pre-post intervention clinical study conducted with total laryngectomees submitted to olfaction rehabilitation by means of the Nasal Airflow-Inducing Maneuver (NAIM) using the University of Pennsylvania Smell Identification Test (UPSIT), Olfactory Acuity Questionnaires, a Monitoring Questionnaire, and the University of Washington Quality of Life Questionnaire (UW-QOL)...
November 2016: CoDAS
https://www.readbyqxmd.com/read/27785336/type-3-adenylyl-cyclase-a-key-enzyme-mediating-the-camp-signaling-in-neuronal-cilia
#12
REVIEW
Liyan Qiu, Robert P LeBel, Daniel R Storm, Xuanmao Chen
Cilia are rigid, centriole-derived, microtubule-based organelles present in a majority of vertebrate cells including neurons. They are considered the cellular "antennae" attuned for detecting a range of extracellular signals including photons, odorants, morphogens, hormones and mechanical forces. The ciliary microenvironment is distinct from most actin-based subcellular structures such as microvilli or synapses. In the nervous system, there is no evidence that neuronal cilia process any synaptic structure. Apparently, the structural features of neuronal cilia do not allow them to harbor any synaptic connections...
2016: International Journal of Physiology, Pathophysiology and Pharmacology
https://www.readbyqxmd.com/read/27773560/surgical-resection-of-sinonasal-hemangiopericytoma-involving-anterior-skull-base-case-reports-and-literature-review
#13
Jonathan C Simmonds, Elie E Rebeiz
Hemangiopericytomas are soft tissue tumors composed of pericytic cells that are characterized by their "staghorn" vascular branching and their variable clinical presentation. Fifteen to 25% of all HPC occur in the head and neck, with only 5% found in the nose or paranasal sinuses. Sinonasal hemangiopericytoma (SNHPC) is considered distinct from its soft tissue counterpart - the former showing a more uniform cellular organization, has convincing pericytic differentiation and is associated with a far better prognosis...
January 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/27772753/antioxidant-and-inflammatory-biomarkers-for-the-identification-of-prodromal-parkinson-s-disease
#14
Jonica Campolo, Renata De Maria, Lorena Cozzi, Marina Parolini, Stefano Bernardi, Paola Proserpio, Lino Nobili, Giorgio Gelosa, Immacolata Piccolo, Elio C Agostoni, Maria G Trivella, Paolo Marraccini
OBJECTIVES: We explored the role of oxidative stress and inflammatory molecules as potential Parkinson (PD) biomarkers and correlated biological with non-motor abnormalities (olfactory impairment and dysautonomia), in patients with idiopathic REM behavior disorder (iRBD) (prodromal PD) and established PD. METHODS: We recruited 11 iRBD and 15 patients with idiopathic PD (Hohen&Yahr 1-3, on L-DOPA and dopamine agonists combination therapy) and 12 age- and sex-matched controls (CTRL)...
November 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27763976/transseptal-subperichondrial-endoscopic-hypophysectomy-with-preservation-of-vital-nasal-structures
#15
Hasmet Yazici, Sedat Doğan, Mehmet Akif Sönmez, Olcay Eser
INTRODUCTION: Pituitary surgery involving different techniques is often applied to the excision of benign adenomas. Operative interventions involved various approaches and techniques. Endoscopic transsphenoidal approach is the less traumatic route to the sella turcica, avoiding brain retraction, and also permitting good visualization, with lower rates of morbidity and mortality. Although mortality of pituitary surgery decreased by advances in surgical techniques morbidities such as synechiae formation, anosmia, bleeding, nasal septal perforations, drying, and incrustation due to traumatization of the nasal structures such as septum, nasal mucosa, and middle concha are the current problems in pituitary surgery...
October 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27762302/machine-learned-pattern-identification-in-olfactory-subtest-results
#16
Jörn Lötsch, Thomas Hummel, Alfred Ultsch
The human sense of smell is often analyzed as being composed of three main components comprising olfactory threshold, odor discrimination and the ability to identify odors. A relevant distinction of the three components and their differential changes in distinct disorders remains a research focus. The present data-driven analysis aimed at establishing a cluster structure in the pattern of olfactory subtest results. Therefore, unsupervised machine-learning was applied onto olfactory subtest results acquired in 10,714 subjects with nine different olfactory pathologies...
October 20, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27723843/olfactory-dysfunction-is-associated-with-the-intake-of-macronutrients-in-korean-adults
#17
Il Gyu Kong, So Young Kim, Min-Su Kim, Bumjung Park, Jin-Hwan Kim, Hyo Geun Choi
BACKGROUND: Olfactory function can impact food selection. However, few large population-based studies have investigated this effect across different age groups. The objective of this study was to assess the association between subjective olfactory dysfunction (anosmia or hyposmia) and macronutrient intake. METHODS: A total of 24,990 participants aged 20 to 98 years were evaluated based on data collected through the Korea National Health and Nutrition Examination Survey from 2008 through 2012...
2016: PloS One
https://www.readbyqxmd.com/read/27679830/kallmann-syndrome-and-deafness-an-uncommon-combination-a-case-report-and-a-literature-review
#18
Nader Salama
BACKGROUND: Kallmann syndrome (Kal S) is an isolated form of hypogonadotrophic hypogonadism in combination with a defect in smell sensation. Depending on the genetic form of the disease, a number of non-reproductive, non-olfactory abnormalities may also be existent. In the present report, we describe a male with Kal S associated with hearing loss, and the successful treatment of his sexual and reproductive defects. CASE: A 23-year-old Caucasian man presented with a lifelong lack of erection and ejaculation...
August 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/27649965/after-oxidation-zinc-nanoparticles-lose-their-ability-to-enhance-responses-to-odorants
#19
Samantha Hagerty, Yasmine Daniels, Melissa Singletary, Oleg Pustovyy, Ludmila Globa, William A MacCrehan, Shin Muramoto, Gheorghe Stan, June W Lau, Edward E Morrison, Iryna Sorokulova, Vitaly Vodyanoy
Electrical responses of olfactory sensory neurons to odorants were examined in the presence of zinc nanoparticles of various sizes and degrees of oxidation. The zinc nanoparticles were prepared by the underwater electrical discharge method and analyzed by atomic force microscopy and X-ray photoelectron spectroscopy. Small (1.2 ± 0.3 nm) zinc nanoparticles significantly enhanced electrical responses of olfactory neurons to odorants. After oxidation, however, these small zinc nanoparticles were no longer capable of enhancing olfactory responses...
December 2016: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/27625887/olfactory-neuroblastoma-followed-by-emergency-surgery-for-symptomatic-intradural-spinal-metastasis-a-case-report
#20
Masatoshi Yunoki, Kenta Suzuki, Atsuhito Uneda, Kimihiro Yoshino
BACKGROUND: Olfactory neuroblastoma (ONB) is a rare, aggressive tumor of the nasal cavity. It may invade the paranasal cavities and anterior skull base locally but may also metastasize to the cervical lymph nodes, lungs, or distant central nervous system. CASE DESCRIPTION: Here, we report a case of ONB in which emergency surgery was performed for intradural spinal metastasis (ISM). The patient was a 52-year-old male who underwent surgery for ONB. The tumor extended from the nasal cavity to the intracranial space and was resected completely...
2016: Surgical Neurology International
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