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https://www.readbyqxmd.com/read/28219749/behavioral-phenotypes-associated-with-mptp-induction-of-partial-lesions-in-common-marmosets-callithrix-jacchus
#1
Kimberley A Phillips, Corinna N Ross, Jennifer Spross, Catherine J Cheng, Alyssa Izquierdo, K C Biju, Cang Chen, Senlin Li, Suzette D Tardif
Parkinson's disease is a chronic neurodegenerative disorder with the core motor features of resting tremor, bradykinesia, rigidity, and postural instability. Non-motor symptoms also occur, and include cognitive dysfunction, mood disorders, anosmia (loss of smell), and REM sleep disturbances. As the development of medications and other therapies for treatment of non-motor symptoms is ongoing, it is essential to have animal models that aid in understanding the neural changes underlying non-motor PD symptoms and serve as a testing ground for potential therapeutics...
February 17, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28213192/trans-frontal-sinus-subcranial-approach-to-olfactory-groove-meningiomas-surgical-results-clinical-and-functional-outcome-in-a-consecutive-series-of-21-patients
#2
Lina Raffaella Barzaghi, Alfio Spina, Filippo Gagliardi, Nicola Boari, Pietro Mortini
BACKGROUND: The trans-frontal-sinus-subcranial approach (TFSSA) allows for direct exposure and removal of olfactory groove meningiomas (OGMs), without any brain retraction. Compared to other skull base approaches (like fronto-orbito-basal, transbasal, subcranial, fronto-orbito-zygomatic and one-and-half approach), it could offer the same advantages but it is less invasive. OBJECT: We report the results in a series of 21 consecutive patients harboring OGMs and operated through TFSSA, in order to propose a viable alternative approach...
February 14, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28145931/endoscopic-endonasal-transsphenoidal-approach-from-the-otolaryngologist-point-of-view
#3
Do Hyun Kim, Yong-Kil Hong, Sin-Soo Jeun, Jae-Sung Park, Dong-Jun Lim, Soo Whan Kim, Jin Hee Cho, Yong Jin Park, YulGyun Kim, Sung Won Kim
OBJECTIVE: In February 2009, the authors' center formed a team of neurosurgeons, otolaryngologists, endocrinologists, and radiologists to perform pituitary surgery using the endoscopic endonasal transsphenoidal approach (EETSA). This paper reviews the authors' experience with the technique, pathological outcomes, hormone profiles, and postoperative complications. METHODS: Between February 2009 and December 2015, 535 patients underwent the EETSA with 2-nostrils/4-hands surgery...
January 31, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28134639/complications-of-nasal-bone-fractures
#4
Kun Hwang, Seung Han Yeom, Suk Hyun Hwang
The aim of this study was to perform a systematic review of the treatment of nasal bone fractures. The search terms ("nasal bone fracture" AND complication) and ("nasal bone fracture" AND [anosmia OR olfaction OR olfactory nerve OR smell]) and (anosmia AND ["nasal preparation" OR "nasal antiseptics"]) were used to search PubMed and SCOPUS. Of the 500 titles, 40 full papers were reviewed. One paper was excluded, and 3 mined papers were added. Ultimately, 12 papers were analyzed. The overall deformity rate was 10...
January 27, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28128693/endoscopic-endonasal-versus-transcranial-approach-to-tuberculum-sellae-and-planum-sphenoidale-meningiomas-in-a-similar-cohort-of-patients
#5
Evan D Bander, Harminder Singh, Colin B Ogilvie, Ryan C Cusic, David J Pisapia, Apostolos John Tsiouris, Vijay K Anand, Theodore H Schwartz
OBJECTIVE Planum sphenoidale (PS) and tuberculum sellae (TS) meningiomas cause visual symptoms due to compression of the optic chiasm. The treatment of choice is surgical removal with the goal of improving vision and achieving complete tumor removal. Two options exist to remove these tumors: the transcranial approach (TCA) and the endonasal endoscopic approach (EEA). Significant controversy exists regarding which approach provides the best results and whether there is a subset of patients for whom an EEA may be more suitable...
January 27, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28124651/aspirin-exacerbated-respiratory-disease-prevalence-diagnosis-treatment-and-considerations-for-the-future
#6
Joshua L Kennedy, Ashley N Stoner, Larry Borish
Aspirin-exacerbated respiratory disease (AERD) is a late onset condition characterized by the Samter triad (aspirin sensitivity [as well as sensitivity to any nonselective cyclooxygenase inhibitor], nasal polyps, asthma) and additional features, including eosinophilic chronic rhinosinusitis, hypereosinophilia, anosmia, frequent absence of atopy, and, intolerance to ingestion of red wine and other alcoholic beverages. The diagnosis is rare, and, because of this, it is also often missed by physicians. However, it is highly overexpressed in patients with severe asthma (and severe chronic rhinosinusitis with nasal polyps), which makes its recognition essential...
November 1, 2016: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28122887/expanding-the-genetic-spectrum-of-anos1-mutations-in-patients-with-congenital-hypogonadotropic-hypogonadism
#7
C I Gonçalves, F Fonseca, T Borges, F Cunha, M C Lemos
STUDY QUESTION: What is the prevalence and functional consequence of ANOS1 (KAL1) mutations in a group of men with congenital hypogonadotropic hypogonadism (CHH)? SUMMARY ANSWER: Three of forty-two (7.1%) patients presented ANOS1 mutations, including a novel splice site mutation leading to exon skipping and a novel contiguous gene deletion associated with ichthyosis. WHAT IS KNOWN ALREADY: CHH is characterized by lack of pubertal development and infertility, due to deficient production, secretion or action of GnRH, and can be associated with anosmia/hyposmia (Kallmann syndrome, KS) or with a normal sense of smell (normosmic CHH)...
January 24, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28120040/is-increased-spinal-nociception-another-hallmark-for-parkinson-s-disease
#8
Evangelia Boura, Maria Stamelou, David Vadasz, Vincent Ries, Marcus M Unger, Georg Kägi, Wolfgang H Oertel, Jens C Möller, Veit Mylius
Augmented spinal nociception during the "off" phase has been observed early in Parkinson's disease further increasing with disease duration. To find out whether increased spinal nociception represents a premotor feature, experimental pain sensitivity was assessed in idiopathic REM-sleep behavior disorder (IRBD) patients with or without signs of a neurodegenerative disorder compared to early Parkinson's disease (ePD) patients and healthy controls (HC). Spinal nociception as measured by the nociceptive flexion reflex (NFR) and experimental pain sensitivity as measured by heat and electrical pain thresholds were determined in 14 IRBD, 15 ePD patients in the medication-defined "off" state and 27 HC in an explorative cohort study...
January 24, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28112015/correlation-between-olfactory-severity-ratings-based-on-olfactory-function-test-scores-and-self-reported-severity-rating-of-olfactory-loss
#9
Jungirl Seok, Ye Ji Shim, Chae-Seo Rhee, Jeong-Whun Kim
CONCLUSION: Olfactory test scores are significantly correlated with self-rated severity scales. However, the statistical rating based on olfactory tests did not strongly agree with the self-reported severity rating. This suggests that there is a discrepancy between olfactory test results and the severity described by patients themselves. OBJECTIVES: This study aimed to identify the correlation between statistical ratings based on test scores and self-rating of the severity of olfactory loss...
January 23, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28111312/dual-channel-endoscopic-indocyanine-green-fluorescence-angiography-for-clipping-of-cerebral-aneurysms
#10
Won-Sang Cho, Jeong Eun Kim, Hyun-Seung Kang, Eun Jin Ha, Minwoong Jung, Choonghee Lee, Il Hyung Shin, Uk Kang
OBJECTIVE: Neuroendoscopy is useful for assessing the status of perforators, parent arteries, and aneurysms beyond the straight line of microscopic view during aneurysm clipping. We aimed to evaluate the clinical usefulness of our endoscopic indocyanine green angiography (eICGA) system, which can simultaneously display both visible light and ICG fluorescent images. METHODS: A total of 16 unruptured aneurysms in 10 patients were surgically clipped via the keyhole approach...
January 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28097500/update-on-aspirin-exacerbated-respiratory-disease
#11
REVIEW
Katharine M Woessner
Aspirin-exacerbated respiratory disease (AERD) is an acquired disease characterized by chronic eosinophilic airway inflammation with underlying dysregulation of arachidonic acid metabolism. The purpose of this paper is to review the latest developments in our understanding of the underlying pathophysiology including the role of eosinophils, mast cells, innate lymphoid cells (ILC2), and platelets. Clinical features such as respiratory reactions induced by alcohol, aggressive nasal polyposis, and anosmia will allow for earlier recognition of these patients in clinical practice...
January 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/27993691/effects-of-znso4-induced-peripheral-anosmia-on-zebrafish-behavior-and-physiology
#12
Murilo S Abreu, Ana C V V Giacomini, Rubens Rodriguez, Allan V Kalueff, Leonardo J G Barcellos
Olfaction plays a key role in modulating behavioral and physiological responses of various animal species, including fishes. Olfactory deficits can be induced in fish experimentally, and utilized to examine the role of olfaction in their normal and pathological behaviors. Here, we examine whether experimental anosmia, evoked by ZnSO4 in adult zebrafish can be associated with behavioral and/or physiological responses. We show that experimental ZnSO4-induced anosmia caused acute, but not prolonged, anxiogenic-like effects on zebrafish behavior tested in the novel tank test...
December 16, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27979773/zinc-gluconate-toxicity-in-wild-type-vs-mt1-2-deficient-mice
#13
Heidi Hsieh, Michael C Horwath, Mary Beth Genter
Previous studies have suggested that oral zinc supplementation can help reduce the duration of the common cold; however, the use of intranasal (IN) zinc is strongly associated with anosmia, or the loss of the sense of smell, in humans. Prior studies from this lab showed that upregulation of metallothioneins (MT) is a rapid and robust response to zinc gluconate (ZG). Therefore, we assessed the role of MT in the recovery of nasal epithelial damage resulting from IN zinc administration. The main studies in this investigation used a high dose of ZG (170mM) to ensure ablation of the olfactory mucosa, so that the progression of histological and functional recovery could be assessed...
December 12, 2016: Neurotoxicology
https://www.readbyqxmd.com/read/27968956/a-genetic-marker-of-the-ackr1-gene-is-present-in-patients-with-type-ii-congenital-smell-loss-who-have-type-i-hyposmia-and-hypogeusia
#14
William A Stateman, Alexandra B Knöppel, Willy A Flegel, Robert I Henkin
PURPOSE: Our previous study of Type II congenital smell loss patients revealed a statistically significant lower prevalence of an FY (ACKR1, formerly DARC) haplotype compared to controls. The present study correlates this genetic feature with subgroups of patients defined by specific smell and taste functions. METHODS: Smell and taste function measurements were performed by use of olfactometry and gustometry to define degree of abnormality of smell and taste function...
November 2016: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/27965198/sniffing-out-significant-pee-values-genome-wide-association-study-of-asparagus-anosmia
#15
Sarah C Markt, Elizabeth Nuttall, Constance Turman, Jennifer Sinnott, Eric B Rimm, Ethan Ecsedy, Robert H Unger, Katja Fall, Stephen Finn, Majken K Jensen, Jennifer R Rider, Peter Kraft, Lorelei A Mucci
OBJECTIVE:  To determine the inherited factors associated with the ability to smell asparagus metabolites in urine. DESIGN:  Genome wide association study. SETTING:  Nurses' Health Study and Health Professionals Follow-up Study cohorts. PARTICIPANTS:  6909 men and women of European-American descent with available genetic data from genome wide association studies. MAIN OUTCOME MEASURE:  Participants were characterized as asparagus smellers if they strongly agreed with the prompt "after eating asparagus, you notice a strong characteristic odor in your urine," and anosmic if otherwise...
December 13, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27941181/hypogonadotropic-hypogonadism-in-a-female-patient-with-congenital-arhinia
#16
Janel Darcy Hunter, Melissa Ann Davis, Jennifer Rachel Law
The association of anosmia and congenital hypogonadotropic hypogonadism (CHH) is well described; however, congenital arhinia is a malformation associated with CHH that occurs much more rarely. There have been three reports of male patients with hypogonadism and congenital arhinia in the literature to date. We present the first case of arhinia associated with CHH in a female patient. A 14 years and 8 months female with congenital arhinia presented with delayed puberty. Physical examination and laboratory evaluation were consistent with hypogonadotropic hypogonadism...
January 1, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/27938610/-characteristics-of-postviral-olfactory-disorder
#17
K Y Li, J Liu, W Xiao, Y Wu, Y Y Ren, Y X Wei
Objective: To explore the clinical characteristics of patients with olfactory dysfunction after upper respiratory tract infection. Methods: Through clinical specialist examination and imaging examination, 95 cases of patients with olfactory dysfunction after upper respiratory tract infection were confirmed, 58 cases in anosmia group and 37 cases in hyposmia group. All were performed by a subjective olfactometry (Sniffin'Sticks test) and a subjective taste function tests. The results were statistically analyzed by SPSS 17...
November 7, 2016: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/27914909/benefits-pitfalls-and-risks-of-phytotherapy-in-clinical-practice-in-otorhinolaryngology
#18
O Laccourreye, A Werner, L Laccourreye, P Bonfils
OBJECTIVES: To elucidate the benefits, pitfalls and risks of phytotherapy in the clinical practice of otorhinolaryngology. MATERIAL AND METHODS: The PubMed and Cochrane databases were searched using the following keywords: phytotherapy, phytomedicine, herbs, otology, rhinology, laryngology, otitis, rhinitis, laryngitis and otorhinolaryngology. Seventy-two articles (18 prospective randomized studies, 4 Cochrane analyses, 4 meta-analysis and 15 reviews of the literature) devoted to clinical studies were analyzed...
November 30, 2016: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/27895246/a-case-of-congenital-anosmia
#19
Umesh Vivekananda, Nader Khandanpour, Salah Omer
No abstract text is available yet for this article.
November 29, 2016: Neurology
https://www.readbyqxmd.com/read/27863011/congenital-anosmia-our-experience-of-eleven-patients-with-aplasia-or-hypoplasia-of-the-olfactory-tract
#20
Jason Powell, Ivan Zammit-Maempel, Sean Carrie
Anosmia is present in approximately 1% of the population and can have a significant impact on quality of life (1) . In contrast to acquired anosmia, congenital anosmia is a relatively rare condition characterized by a complete lack of olfactory perception and the aplasia or hypoplasia of the olfactory bulb. Kallmann syndrome (congenital hypogonadotropic hypogonadism and anosmia) is the best known condition assoicated with congenital anosmia (2,3) . Kallmann Syndrome has a prevalence of around 1 in 8000, and is five times more common in men than women (2,3) ...
November 14, 2016: Clinical Otolaryngology
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