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https://www.readbyqxmd.com/read/28716176/systematic-review-of-patient-reported-outcomes-after-revision-endoscopic-sinus-surgery
#1
Shashi Prasad, Eric Fong, Eng H Ooi
BACKGROUND: Revision endoscopic sinus surgery (RESS) may be required for partially controlled or uncontrolled chronic rhinosinusitis. Studies that reported technical success, e.g., sinus ostia patency after RESS, do not address whether the patient's symptoms and quality of life (QOL) improve after surgery. However, patient-reported outcome measures (PROM) are useful to assess the impact of sinus surgery on a patient's symptoms and QOL. OBJECTIVE: This systematic review was undertaken to evaluate the impact of RESS on PROMs...
July 1, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28667919/a-rare-case-report-of-bilateral-choanal-atresia-in-an-adult
#2
Said Anajar, Jawad Hassnaoui, Sami Rouadi, Reda Abada, Mohammed Roubal, Mohammed Mahtar
INTRODUCTION: Adult choanal atresia is a rare congenital malformation of the nasal cavity characterized by the complete obliteration of the posterior choanae, only ninth cases are reported in the literature, we present in our observation the tenth case of adult bilateral choanal atresia. PRESENTATION OF CASE: A 18-year-old man presented at our department with complaints of nasal obstruction, nasal discharge, snoring, anosmia, and mouth breathing since childhood...
May 19, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28656349/structural-determinants-of-a-conserved-enantiomer-selective-carvone-binding-pocket-in-the-human-odorant-receptor-or1a1
#3
Christiane Geithe, Jonas Protze, Franziska Kreuchwig, Gerd Krause, Dietmar Krautwurst
Chirality is a common phenomenon within odorants. Most pairs of enantiomers show only moderate differences in odor quality. One example for enantiomers that are easily discriminated by their odor quality is the carvones: humans significantly distinguish between the spearmint-like (R)-(-)-carvone and caraway-like (S)-(+)-carvone enantiomers. Moreover, for the (R)-(-)-carvone, an anosmia is observed in about 8% of the population, suggesting enantioselective odorant receptors (ORs). With only about 15% de-orphaned human ORs, the lack of OR crystal structures, and few comprehensive studies combining in silico and experimental approaches to elucidate structure-function relations of ORs, knowledge on cognate odorant/OR interactions is still sparse...
June 27, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28651678/latent-cognitive-phenotypes-in-de-novo-parkinson-s-disease-a-person-centered-approach
#4
Denise R LaBelle, Ryan R Walsh, Sarah J Banks
OBJECTIVES: Cognitive impairment is an important aspect of Parkinson's disease (PD), but there is considerable heterogeneity in its presentation. This investigation aims to identify and characterize latent cognitive phenotypes in early PD. METHODS: Latent class analysis, a data-driven, person-centered, cluster analysis was performed on cognitive data from the Parkinson's Progressive Markers Initiative baseline visit. This analytic method facilitates identification of naturally occurring endophenotypes...
June 27, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28643390/oral-disorders-saliva-secretion-and-oral-health-related-quality-of-life-in-patients-with-primary-sj%C3%A3-gren-s-syndrome
#5
Shermin Rusthen, Alix Young, Bente B Herlofson, Lara A Aqrawi, Morten Rykke, Lene H Hove, Øyvind Palm, Janicke L Jensen, Preet B Singh
Chemosensory function, burning sensations in the tongue (BST), halitosis, saliva secretion, and oral health-related quality of life (OHRQoL) were investigated in patients with primary Sjögren's syndrome (pSS). In 31 patients with pSS and 33 controls, olfactory and gustatory functions were evaluated. Self-reported complaints of dysgeusia, BST, and halitosis were recorded. Saliva secretion rates were measured and OHRQoL was assessed using the short-form Oral Health Impact Profile (OHIP-14). Patients had significantly lower olfactory (8...
June 23, 2017: European Journal of Oral Sciences
https://www.readbyqxmd.com/read/28583920/idiopathic-hypogonadotropic-hypogonadism-reversal-after-testosterone-replacement-in-a-34-year-old-male
#6
Owais Rashid, Nanik Ram, Saad Farooq, Zareen Kiran
A 34-year-old male presented to the endocrinology clinic with the complaint of the absence of facial, axillary and pubic hairs. Further history revealed absent ejaculations and decreased early morning erections. The patient had no history of headaches, visual problems or anosmia. On physical examination, there were sparse facial, axillary and pubic hairs, bilateral gynaecomastia, stretch penile length of 5 cm and bilateral testicular volume of 10 mL. Laboratory investigations showed low luteinising hormone, follicular stimulating hormone and testosterone with normal prolactin and thyroid profile...
June 5, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28582956/endoscopic-endonasal-transsphenoidal-approach-from-the-surgeon-point-of-view
#7
Do Hyun Kim, Yong-Kil Hong, Sin-Soo Jeun, Jae-Sung Park, Dong-Jun Lim, Soo Whan Kim, Jin Hee Cho, Yong Jin Park, YulGyun Kim, Sung Won Kim
OBJECTIVE: In February 2009, the authors' center formed a team of neurosurgeons, otolaryngologists, endocrinologists, and radiologists to perform pituitary surgery using the endoscopic endonasal transsphenoidal approach (EETSA). This paper reviews the authors' experience with the technique, pathological outcomes, hormone profiles, and postoperative complications. METHODS: Between February 2009 and December 2015, 535 patients underwent the EETSA with 2-nostrils/4-hands surgery...
June 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28572688/isolated-congenital-anosmia-and-cnga2-mutation
#8
M Reza Sailani, Inlora Jingga, Seyed Hashem MirMazlomi, Fatemeh Bitarafan, Jonathan A Bernstein, Michael P Snyder, Masoud Garshasbi
Isolated congenital anosmia (ICA) is a rare condition that is associated with life-long inability to smell. Here we report a genetic characterization of a large Iranian family segregating ICA. Whole exome sequencing in five affected family members and five healthy members revealed a stop gain mutation in CNGA2 (OMIM 300338) (chrX:150,911,102; CNGA2. c.577C > T; p.Arg193*). The mutation segregates in an X-linked pattern, as all the affected family members are hemizygotes, whereas healthy family members are either heterozygote or homozygote for the reference allele...
June 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28543731/neuroimaging-biomarkers-and-impaired-olfaction-in-cognitively-normal-individuals
#9
Maria Vassilaki, Teresa J Christianson, Michelle M Mielke, Yonas E Geda, Walter K Kremers, Mary M Machulda, David S Knopman, Ronald C Petersen, Val J Lowe, Clifford R Jack, Rosebud O Roberts
OBJECTIVE: There is a need for inexpensive noninvasive tests to identify older healthy persons at risk for Alzheimer disease (AD) for enrollment in AD prevention trials. Our objective was to examine whether abnormalities in neuroimaging measures of amyloid and neurodegeneration are correlated with odor identification (OI) in the population-based Mayo Clinic Study of Aging. METHODS: Cognitively normal (CN) participants had olfactory function assessed using the Brief Smell Identification Test (B-SIT), underwent magnetic resonance imaging (n = 829) to assess a composite AD signature cortical thickness and hippocampal volume (HVa), and underwent (11) C-Pittsburgh compound B (n = 306) and (18) fluorodeoxyglucose (n = 305) positron emission tomography scanning to assess amyloid accumulation and brain hypometabolism, respectively...
June 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28534048/the-first-report-of-cadasil-in-peru-olfactory-dysfunction-on-initial-presentation
#10
Anastasia Vishnevetsky, Miguel Inca-Martinez, Karina Milla-Neyra, Danny Moises Barrientos-Iman, Ivan Cornejo-Herrera, Carlos Cosentino, Mario Cornejo-Olivas
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) is a rare, heritable, small vessel vascular disease caused by mutations in the Notch3 gene that is characterized by migraines, subcortical vascular events, cognitive decline, and mood disturbances. However, many CADASIL cases present with unusual symptoms such as status epilepticus, a movement disorder, or sensory dysfunction. This study describes the clinical, genetic, and radiologic characteristics of a Peruvian family with CADASIL in which multiple family members presented with severe olfactory deficits...
December 2016: ENeurologicalSci
https://www.readbyqxmd.com/read/28531300/anosmia-a-clinical-review
#11
Sanne Boesveldt, Elbrich M Postma, Duncan Boak, Antje Welge-Luessen, Veronika Schöpf, Joel D Mainland, Jeffrey Martens, John Ngai, Valerie B Duffy
Anosmia and hyposmia, the inability or decreased ability to smell, is estimated to afflict 3-20% of the population. Risk of olfactory dysfunction increases with old age and may also result from chronic sinonasal diseases, severe head trauma, and upper respiratory infections, or neurodegenerative diseases. These disorders impair the ability to sense warning odors in foods and the environment, as well as hinder the quality of life related to social interactions, eating, and feelings of well-being. This article reports and extends on a clinical update commencing at the 2016 Association for Chemoreception Sciences annual meeting...
May 22, 2017: Chemical Senses
https://www.readbyqxmd.com/read/28519966/understanding-the-relationship-between-olfactory-specific-quality-of-life-objective-olfactory-loss-and-patient-factors-in-chronic-rhinosinusitis
#12
Jose L Mattos, Rodney J Schlosser, Kristina A Storck, Zachary M Soler
BACKGROUND: Chronic rhinosinusitis (CRS) significantly impacts olfaction. However, the relationship between objective olfaction and patient-reported olfactory-specific quality of life (QOL) is not well understood. Furthermore, objective olfactory testing can be time consuming, so we sought to determine if patient-reported olfactory QOL can be used as screening tool for olfactory dysfunction. METHODS: Olfactory dysfunction was evaluated in 109 patients with CRS using the Questionnaire of Olfactory Disorders-Negative Statements (QOD-NS) and the Sniffin' Sticks Test, assessing for olfactory threshold, discrimination, identification, and overall composite scores (TDI; composite score of threshold, discrimination, and identification)...
July 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28508200/individual-variability-of-human-olfactory-sensitivity-to-volatile-steroids-environmental-and-genetic-factors
#13
V V Voznessenskaya, M A Klyuchnikova
The sensitivity to androstenone and possible factors, determining the sensitivity were investigated for the large sample of inhabitants of central Russia (n = 860). Specific anosmia was detected in 48.8% of subjects. Women were more sensitive to androstenone than men. The proportion of men, but not women perceiving the smell of androstenone as a strong one in the concentration used decreased with age. Smoking, blood group, or ethnicity had no significant effect on the expression of specific anosmia and the perception of androstenone odor intensity...
March 2017: Doklady Biological Sciences: Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections
https://www.readbyqxmd.com/read/28498937/the-prevalence-of-anosmia-and-associated-factors-among-u-s-black-and-white-older-adults
#14
Jing Dong, Jayant M Pinto, Xuguang Guo, Alvaro Alonso, Gregory Tranah, Jane A Cauley, Melissa Garcia, Suzanne Satterfield, Xuemei Huang, Tamara Harris, Thomas H Mosley, Honglei Chen
Background: Olfactory impairment is common among older adults; however, data are largely limited to whites. Methods: We conducted pooled analyses of two community-based studies: the Atherosclerosis Risk in Communities study (ARIC, 1,398 blacks and 4,665 whites), and the Health, Aging, and Body Composition study (Health ABC, 958 blacks and 1,536 whites) to determine the prevalence of anosmia and associated factors for black and white older adults in the United States...
May 11, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28484905/historical-perspectives-on-ancient-greek-derived-a-prefixed-nomenclature-for-acquired-neurocognitive-impairment
#15
REVIEW
Philip Gerard Gasquoine
Distinct forms of acquired neurocognitive impairment are often described by "a" prefixed terms that derive from ancient Greek (and in one case Latin). Two modern English language neurological and neuropsychological reference books were searched to identify 17 such terms in contemporary usage: amnesia, akinesia, ataxia, aphasia, agraphia, anosmia, apraxia, athetosis, ageusia, achromatopsia, agnosia, alexia, amusia, anomia, anarthria, anosognosia, and acalculia. These were traced to their initial association with acquired neurocognitive impairment in German, English, and French language medical publications from the late 18th, 19th, and early 20th centuries (1770 through 1920)...
May 8, 2017: Neuropsychology Review
https://www.readbyqxmd.com/read/28471462/the-role-of-metals-in-mammalian-olfaction-of-low-molecular-weight-organosulfur-compounds
#16
REVIEW
Eric Block, Victor S Batista, Hiroaki Matsunami, Hanyi Zhuang, Lucky Ahmed
Covering: up to the end of 2017While suggestions concerning the possible role of metals in olfaction and taste date back 50 years, only recently has it been possible to confirm these proposals with experiments involving individual olfactory receptors (ORs). A detailed discussion of recent experimental results demonstrating the key role of metals in enhancing the response of human and other vertebrate ORs to specific odorants is presented against the backdrop of our knowledge of how the sense of smell functions both at the molecular and whole animal levels...
May 10, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/28468171/complications-of-nasal-bone-fractures
#17
Kun Hwang, Seung Han Yeom, Suk Hyun Hwang
The aim of this study was to perform a systematic review of the treatment of nasal bone fractures. The search terms ("nasal bone fracture" AND complication) and ("nasal bone fracture" AND [anosmia OR olfaction OR olfactory nerve OR smell]) and (anosmia AND ["nasal preparation" OR "nasal antiseptics"]) were used to search PubMed and SCOPUS. Of the 500 titles, 40 full papers were reviewed. One paper was excluded, and 3 mined papers were added. Ultimately, 12 papers were analyzed. The overall deformity rate was 10...
May 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28459173/olfactory-loss-and-regain-lessons-for-neuroplasticity
#18
Johanna L Reichert, Veronika Schöpf
For the visual and auditory senses, an array of studies has reported on neuronal reorganization processes after sensory loss. In contrast to this, neuroplasticity has been investigated only scarcely after loss of the olfactory sense. The present review focuses on the current extent of literature on structural and functional neuroplasticity effects after loss, with a focus on magnetic resonance imaging-based studies. We also include findings on the regain of the olfactory sense, for example after successful olfactory training...
April 1, 2017: Neuroscientist: a Review Journal Bringing Neurobiology, Neurology and Psychiatry
https://www.readbyqxmd.com/read/28452719/anosmia-treatment-by-platelet-rich-plasma-injection
#19
Panayiota Mavrogeni, Angelos Kanakopoulos, Stephanie Maihoub, Magdolna Krasznai, Agnes Szirmai
INTRODUCTION: Platelets are known for their key role in hemostasis and controlling the bleeding after injury. The fact that platelets secrete growth factors and active metabolites means that their applied use can have a positive influence in clinical situations requiring rapid healing and tissue regeneration. OBJECTIVES: Platelet Rich Plasma has been described as a promising but unproven therapy. MATERIALS AND METHODS: Whole blood was undergoing one stage of centrifugation...
April 19, 2017: International Tinnitus Journal
https://www.readbyqxmd.com/read/28447155/fine-tuned-evaluation-of-olfactory-function-in-patients-operated-for-nasal-polyposis
#20
Marie-Hortense Sonnet, Duc Trung Nguyen, Phi-Linh Nguyen-Thi, Fabien Arous, Roger Jankowski, Cécile Rumeau
Given the forced-choice procedure of the identification test, patients with profound anosmia are more likely to have higher identification scores by chance than patients with hyposmia or normosmia. This may be a confusing factor when assessing the sense of smell, which alters the appreciation of real olfaction improvement. The aim of this study was to fine-tune the results of the identification Sniffin' Sticks test before and 6 weeks after surgery using the real identification score. A total of 133 patients underwent the Identification (I) and Threshold (T) tests the day before and 6 weeks after nasalization surgery...
April 26, 2017: European Archives of Oto-rhino-laryngology
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