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JOURNAL ARTICLE
George M Anderson, Edwin H Cook, Randy D Blakely, James S Sutcliffe, Jeremy Veenstra-VanderWeele
We believe there are serious problems with a recently published and highly publicized paper entitled "Serotonin reduction in post-acute sequelae of viral infection." The blood centrifugation procedure reportedly used by Wong et al would produce plasma that is substantially (over 95%) depleted of platelets. Given this, their published mean plasma serotonin values of 1.2 uM and 2.4 uM for the control/contrast groups appear to be at least 30 to 60 times too high and should be disregarded. The plasma serotonin values reported for the long COVID and viremia patients also should be disregarded, as should any comparisons to the control/contrast groups...
2024: Journal of Inflammation Research
#2
JOURNAL ARTICLE
Haylee Mesa, Jonathan Meade, Paula Gajewski-Kurdziel, Randy D Blakely, Qi Zhang
Recent advancements in tissue-clearing techniques and volumetric imaging have greatly facilitated visualization and quantification of biomolecules, organelles, and cells in intact organs or even entire organisms. Generally, there are two types of clearing methods: hydrophobic and hydrophilic (i.e., clearing with organic or aqueous solvents, respectively). The popular iDISCO approach and its modifications are hydrophobic methods that involve dehydration, delipidation, decolorization (optional), decalcification (optional), and refractive-index (RI) matching steps...
March 5, 2024: Bio-protocol
#3
JOURNAL ARTICLE
Busenur Ceyhan, Parisa Nategh, Mehrnoosh Neghabi, Jacob A LaMar, Shalaka Konjalwar, Peter Rodriguez, Maureen K Hahn, Matthew Gross, Gregory Grumbar, Kenneth J Salleng, Randy D Blakely, Mahsa Ranji
OBJECTIVE: Metabolic changes have been extensively documented in neurodegenerative brain disorders, including Parkinson's disease and Alzheimer's disease (AD). Mutations in the C. elegans swip-10 gene result in dopamine (DA) dependent motor dysfunction accompanied by DA neuron degeneration. Recently, the putative human ortholog of swip-10 (MBLAC1) was implicated as a risk factor in AD, a disorder that, like PD, has been associated with mitochondrial dysfunction. Interestingly, the AD risk associated with MBLAC1 arises in subjects with cardiovascular morbidity, suggesting a broader functional insult arising from reduced MBLAC1 protein expression and one possibly linked to metabolic alterations...
2024: IEEE Journal of Translational Engineering in Health and Medicine
#4
REVIEW
Paula A Gajeswski-Kurdziel, Allison E Walsh, Randy D Blakely
Serotonin (5-hydroxytryptamine, 5-HT) signaling plays an important role in dynamic control of peripheral and central nervous system physiology, with altered 5-HT homeostasis implicated in a significant number of disorders, ranging from pulmonary, bowel, and metabolic disease to depression, obsessive-compulsive disorder, and autism spectrum disorder (ASD). The presynaptic, 5-HT transporter (SERT) has a well-established role in regulating 5-HT signaling and is a target of widely prescribed psychotherapeutics, the 5-HT selective reuptake inhibitors (SSRIs)...
2024: Current research in physiology
#5
JOURNAL ARTICLE
Ralph Gradisch, Katharina Schlögl, Erika Lazzarin, Marco Niello, Julian Maier, Felix P Mayer, Leticia Alves da Silva, Sophie M C Skopec, Randy D Blakely, Harald H Sitte, Marko D Mihovilovic, Thomas Stockner
The presynaptic serotonin transporter (SERT) clears extracellular serotonin following vesicular release to ensure temporal and spatial regulation of serotonergic signalling and neurotransmitter homeostasis. Prescription drugs used to treat neurobehavioral disorders, including depression, anxiety, and obsessive-compulsive disorder, trap SERT by blocking the transport cycle. In contrast, illicit drugs of abuse like amphetamines reverse SERT directionality, causing serotonin efflux. Both processes result in increased extracellular serotonin levels...
January 10, 2024: Nature Communications
#6
JOURNAL ARTICLE
Busenur Ceyhan, Jacob LaMar, Parisa Nategh, Mehrnoosh Neghabi, Shalaka Konjalwar, Peter Rodriguez, Maureen K Hahn, Randy D Blakely, Mahsa Ranji
Metabolic changes have been extensively documented in brain tissue undergoing neurodegeneration, including Parkinson's disease and Alzheimer's disease (AD). Mutations in the C. elegans swip-10 gene result in dopamine (DA) dependent motor dysfunction accompanied by DA neuron degeneration. Recently, the putative human ortholog of swip-10 (MBLAC1) was implicated as a risk factor in AD, that like PD, has been associated with mitochondrial dysfunction. Interestingly, the AD risk associated with MBLAC1 arises in subjects with cardiovascular morbidity, suggesting the possibility of a broader functional insult arising from reduced MBLAC1 protein expression, and one possibly linked to metabolic alterations...
July 2023: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
#7
REVIEW
Felix P Mayer, Adele Stewart, Randy D Blakely
Aberrant dopamine (DA) signaling has been implicated in various neuropsychiatric disorders, including attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), schizophrenia, bipolar disorder (BPD) and addiction. The availability of extracellular DA is sculpted by exocytotic release of vesicular DA and subsequent transporter-mediated clearance, rendering the presynaptic DA transporter (DAT) a crucial regulator of DA neurotransmission. D2-type DA autoreceptors (D2ARs) regulate multiple aspects of DA homeostasis, including i) DA synthesis, ii) vesicular release, iii) DA neuron firing, and iv), the surface expression of DAT and DAT- mediated DA clearance...
November 21, 2023: Basic & Clinical Pharmacology & Toxicology
#8
REVIEW
Peter Rodriguez, Randy D Blakely
Receiving a neurodegenerative disease (NDD) diagnosis, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, or amyotrophic lateral sclerosis, is devastating, particularly given the limited options for treatment. Advances in genetic technologies have allowed for efficient modeling of NDDs in animals and brought hope for new disease-modifying medications. The complexity of the mammalian brain and the costs and time needed to identify and develop therapeutic leads limits progress. Modeling NDDs in invertebrates, such as the fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans, offers orders of magnitude increases in speed of genetic analysis and manipulation, and can be pursued at substantially reduced cost, providing an important, platform complement and inform research with mammalian NDD models...
October 5, 2023: Journal of Cellular Physiology
#9
JOURNAL ARTICLE
Tiago C Luis, Nikolaos Barkas, Joana Carrelha, Alice Giustacchini, Stefania Mazzi, Ruggiero Norfo, Bishan Wu, Affaf Aliouat, Jose A Guerrero, Alba Rodriguez-Meira, Tiphaine Bouriez-Jones, Iain C Macaulay, Maria Jasztal, Guangheng Zhu, Heyu Ni, Matthew J Robson, Randy D Blakely, Adam J Mead, Claus Nerlov, Cedric Ghevaert, Sten Eirik W Jacobsen
Hematopoietic stem cells (HSCs) residing in specialized niches in the bone marrow are responsible for the balanced output of multiple short-lived blood cell lineages in steady-state and in response to different challenges. However, feedback mechanisms by which HSCs, through their niches, sense acute losses of specific blood cell lineages remain to be established. While all HSCs replenish platelets, previous studies have shown that a large fraction of HSCs are molecularly primed for the megakaryocyte-platelet lineage and are rapidly recruited into proliferation upon platelet depletion...
September 28, 2023: Nature Communications
#10
JOURNAL ARTICLE
Tamara T Haque, Marcela T Taruselli, Sydney A Kee, Jordan M Dailey, Neha Pondicherry, Paula A Gajewski-Kurdziel, Matthew P Zellner, Daniel J Stephenson, H Patrick MacKnight, David B Straus, Roma Kankaria, Kaitlyn G Jackson, Alena P Chumanevich, Yoshihiro Fukuoka, Lawrence B Schwartz, Randy D Blakely, Carole A Oskeritzian, Charles E Chalfant, Rebecca K Martin, John J Ryan
There is a clinical need for new treatment options addressing allergic disease. Selective serotonin reuptake inhibitors (SSRIs) are a class of antidepressants that have anti-inflammatory properties. We tested the effects of the SSRI fluoxetine on IgE-induced function of mast cells, which are critical effectors of allergic inflammation. We showed that fluoxetine treatment of murine or human mast cells reduced IgE-mediated degranulation, cytokine production, and inflammatory lipid secretion, as well as signaling mediated by the mast cell activator ATP...
September 12, 2023: Science Signaling
#11
Jonatan Fullerton Støier, Trine Nygaard Jørgensen, Thomas Sparsø, Henrik Berg Rasmussen, Vivek Kumar, Amy Hauck Newman, Randy D Blakely, Thomas Werge, Ulrik Gether, Freja Herborg
Affective or mood disorders are a leading cause of disability worldwide. The serotonergic system has been heavily implicated in the complex etiology and serves as a therapeutic target. The serotonin transporter (SERT) is a major regulator of serotonin neurotransmission, yet the disease-relevance of impaired SERT function remains unknown. Here, we present the first identification and functional characterization of disruptive coding SERT variants found in patients with psychiatric diseases. In a unique cohort of 144 patients characterized by treatment-resistant chronic affective disorders with a lifetime history of electroconvulsive therapy, we identified two previously uncharacterized coding SERT variants: SERT-N217S and SERT-A500T...
August 29, 2023: medRxiv
#12
JOURNAL ARTICLE
Jiafa Ren, Kang Liu, Buyun Wu, Xiaohan Lu, Lianqin Sun, Jamie R Privratsky, Changying Xing, Matthew J Robson, Huijuan Mao, Randy D Blakely, Koki Abe, Tomokazu Souma, Steven D Crowley
SIGNIFICANCE STATEMENT: Activation of the type 1 IL-1 receptor (IL-1R1) triggers a critical innate immune signaling cascade that contributes to the pathogenesis of AKI. However, blockade of IL-1 signaling in AKI has not consistently demonstrated kidney protection. The current murine experiments show that IL-1R1 activation in the proximal tubule exacerbates toxin-induced AKI and cell death through local suppression of apolipoprotein M. By contrast, IL-1R1 activation in endothelial cells ameliorates AKI by restoring VEGFA-dependent endothelial cell viability...
October 1, 2023: Journal of the American Society of Nephrology: JASN
#13
Felix P Mayer, Adele Stewart, Durairaj Ragu Varman, Amy E Moritz, James D Foster, Anthony W Owens, Lorena B Areal, Raajaram Gowrishankar, Michelle Velez, Kyria Wickham, Hannah Phelps, Rania Katamish, Maximilian Rabil, Lankupalle D Jayanthi, Roxanne A Vaughan, Lynette C Daws, Randy D Blakely, Sammanda Ramamoorthy
Aberrant dopamine (DA) signaling is implicated in schizophrenia, bipolar disorder (BPD), autism spectrum disorder (ASD), substance use disorder, and attention-deficit/hyperactivity disorder (ADHD). Treatment of these disorders remains inadequate. We established that the human DA transporter (DAT) coding variant (DAT Val559), identified in individuals with ADHD, ASD, or BPD, exhibits anomalous DA efflux (ADE) that is blocked by therapeutic amphetamines and methylphenidate. As the latter agents have high abuse liability, we exploited DAT Val559 knock-in mice to identify non-addictive agents that can normalize DAT Val559 functional and behavioral effects ex viv o and in vivo ...
May 3, 2023: bioRxiv
#14
Jung Ho Hyun, Patrick Hannan, Hideki Iwamoto, Randy D Blakely, Hyung-Bae Kwon
Cognitive flexibility is a brain’s ability to switch between different rules or action plans depending on the context. However, cellular level understanding of cognitive flexibility have been largely unexplored. We probed a specific serotonergic pathway from dorsal raphe nuclei (DRN) to the orbitofrontal cortex (OFC) while animals are performing reversal learning task. We found that serotonin release from DRN to the OFC promotes reversal learning. A long-range connection between these two brain regions was confirmed anatomically and functionally...
March 9, 2023: bioRxiv
#15
JOURNAL ARTICLE
Blake D Colman, Anthony J Fok, Randy H Kardon
No abstract text is available yet for this article.
March 1, 2023: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
#16
JOURNAL ARTICLE
Erin M Buchanan, Savannah C Lewis, Bastien Paris, Patrick S Forscher, Jeffrey M Pavlacic, Julie E Beshears, Shira Meir Drexler, Amélie Gourdon-Kanhukamwe, Peter R Mallik, Miguel Alejandro A Silan, Jeremy K Miller, Hans IJzerman, Hannah Moshontz, Jennifer L Beaudry, Jordan W Suchow, Christopher R Chartier, Nicholas A Coles, MohammadHasan Sharifian, Anna Louise Todsen, Carmel A Levitan, Flávio Azevedo, Nicole Legate, Blake Heller, Alexander J Rothman, Charles A Dorison, Brian P Gill, Ke Wang, Vaughan W Rees, Nancy Gibbs, Amit Goldenberg, Thuy-Vy Thi Nguyen, James J Gross, Gwenaêl Kaminski, Claudia C von Bastian, Mariola Paruzel-Czachura, Farnaz Mosannenzadeh, Soufian Azouaghe, Alexandre Bran, Susana Ruiz-Fernandez, Anabela Caetano Santos, Niv Reggev, Janis H Zickfeld, Handan Akkas, Myrto Pantazi, Ivan Ropovik, Max Korbmacher, Patrícia Arriaga, Biljana Gjoneska, Lara Warmelink, Sara G Alves, Gabriel Lins de Holanda Coelho, Stefan Stieger, Vidar Schei, Paul H P Hanel, Barnabas Szaszi, Maksim Fedotov, Jan Antfolk, Gabriela-Mariana Marcu, Jana Schrötter, Jonas R Kunst, Sandra J Geiger, Adeyemi Adetula, Halil Emre Kocalar, Julita Kielińska, Pavol Kačmár, Ahmed Bokkour, Oscar J Galindo-Caballero, Ikhlas Djamai, Sara Johanna Pöntinen, Bamikole Emmanuel Agesin, Teodor Jernsäther, Anum Urooj, Nikolay R Rachev, Maria Koptjevskaja-Tamm, Murathan Kurfalı, Ilse L Pit, Ranran Li, Sami Çoksan, Dmitrii Dubrov, Tamar Elise Paltrow, Gabriel Baník, Tatiana Korobova, Anna Studzinska, Xiaoming Jiang, John Jamir Benzon R Aruta, Jáchym Vintr, Faith Chiu, Lada Kaliska, Jana B Berkessel, Murat Tümer, Sara Morales-Izquierdo, Hu Chuan-Peng, Kevin Vezirian, Anna Dalla Rosa, Olga Bialobrzeska, Martin R Vasilev, Julia Beitner, Ondřej Kácha, Barbara Žuro, Minja Westerlund, Mina Nedelcheva-Datsova, Andrej Findor, Dajana Krupić, Marta Kowal, Adrian Dahl Askelund, Razieh Pourafshari, Jasna Milošević Đorđević, Nadya-Daniela Schmidt, Ekaterina Baklanova, Anna Szala, Ilya Zakharov, Marek A Vranka, Keiko Ihaya, Caterina Grano, Nicola Cellini, Michał Białek, Lisa Anton-Boicuk, Ilker Dalgar, Arca Adıgüzel, Jeroen P H Verharen, Princess Lovella G Maturan, Angelos P Kassianos, Raquel Oliveira, Martin Čadek, Vera Cubela Adoric, Asil Ali Özdoğru, Therese E Sverdrup, Balazs Aczel, Danilo Zambrano, Afroja Ahmed, Christian K Tamnes, Yuki Yamada, Leonhard Volz, Naoyuki Sunami, Lilian Suter, Luc Vieira, Agata Groyecka-Bernard, Julia Arhondis Kamburidis, Ulf-Dietrich Reips, Mikayel Harutyunyan, Gabriel Agboola Adetula, Tara Bulut Allred, Krystian Barzykowski, Benedict G Antazo, Andras N Zsido, Dušana Dušan Šakan, Wilson Cyrus-Lai, Lina Pernilla Ahlgren, Matej Hruška, Diego Vega, Efisio Manunta, Aviv Mokady, Mariagrazia Capizzi, Marcel Martončik, Nicolas Say, Katarzyna Filip, Roosevelt Vilar, Karolina Staniaszek, Milica Vdovic, Matus Adamkovic, Niklas Johannes, Nandor Hajdu, Noga Cohen, Clara Overkott, Dino Krupić, Barbora Hubena, Gustav Nilsonne, Giovanna Mioni, Claudio Singh Solorzano, Tatsunori Ishii, Zhang Chen, Elizaveta Kushnir, Cemre Karaarslan, Rafael R Ribeiro, Ahmed Khaoudi, Małgorzata Kossowska, Jozef Bavolar, Karlijn Hoyer, Marta Roczniewska, Alper Karababa, Maja Becker, Renan P Monteiro, Yoshihiko Kunisato, Irem Metin-Orta, Sylwia Adamus, Luca Kozma, Gabriela Czarnek, Artur Domurat, Eva Štrukelj, Daniela Serrato Alvarez, Michal Parzuchowski, Sébastien Massoni, Johanna Czamanski-Cohen, Ekaterina Pronizius, Fany Muchembled, Kevin van Schie, Aslı Saçaklı, Evgeniya Hristova, Anna O Kuzminska, Abdelilah Charyate, Gijsbert Bijlstra, Reza Afhami, Nadyanna M Majeed, Erica D Musser, Miroslav Sirota, Robert M Ross, Siu Kit Yeung, Marietta Papadatou-Pastou, Francesco Foroni, Inês A T Almeida, Dmitry Grigoryev, David M G Lewis, Dawn L Holford, Steve M J Janssen, Srinivasan Tatachari, Carlota Batres, Jonas K Olofsson, Shimrit Daches, Anabel Belaus, Gerit Pfuhl, Nadia Sarai Corral-Frias, Daniela Sousa, Jan Philipp Röer, Peder Mortvedt Isager, Hendrik Godbersen, Radoslaw B Walczak, Natalia Van Doren, Dongning Ren, Tripat Gill, Martin Voracek, Lisa M DeBruine, Michele Anne, Sanja Batić Očovaj, Andrew G Thomas, Alexios Arvanitis, Thomas Ostermann, Kelly Wolfe, Nwadiogo Chisom Arinze, Carsten Bundt, Claus Lamm, Robert J Calin-Jageman, William E Davis, Maria Karekla, Saša Zorjan, Lisa M Jaremka, Jim Uttley, Monika Hricova, Monica A Koehn, Natalia Kiselnikova, Hui Bai, Anthony J Krafnick, Busra Bahar Balci, Tonia Ballantyne, Samuel Lins, Zahir Vally, Celia Esteban-Serna, Kathleen Schmidt, Paulo Manuel L Macapagal, Paulina Szwed, Przemysław Marcin Zdybek, David Moreau, W Matthew Collins, Jennifer A Joy-Gaba, Iris Vilares, Ulrich S Tran, Jordane Boudesseul, Nihan Albayrak-Aydemir, Barnaby James Wyld Dixson, Jennifer T Perillo, Ana Ferreira, Erin C Westgate, Christopher L Aberson, Azuka Ikechukwu Arinze, Bastian Jaeger, Muhammad Mussaffa Butt, Jaime R Silva, Daniel Shafik Storage, Allison P Janak, William Jiménez-Leal, Jose A Soto, Agnieszka Sorokowska, Randy McCarthy, Alexa M Tullett, Martha Frias-Armenta, Matheus Fernando Felix Ribeiro, Andree Hartanto, Paul A G Forbes, Megan L Willis, María Del Carmen Tejada R, Adriana Julieth Olaya Torres, Ian D Stephen, David C Vaidis, Anabel de la Rosa-Gómez, Karen Yu, Clare A M Sutherland, Mathi Manavalan, Behzad Behzadnia, Jan Urban, Ernest Baskin, Joseph P McFall, Chisom Esther Ogbonnaya, Cynthia H Y Fu, Rima-Maria Rahal, Izuchukwu L G Ndukaihe, Thomas J Hostler, Heather Barry Kappes, Piotr Sorokowski, Meetu Khosla, Ljiljana B Lazarevic, Luis Eudave, Johannes K Vilsmeier, Elkin O Luis, Rafał Muda, Elena Agadullina, Rodrigo A Cárcamo, Crystal Reeck, Gulnaz Anjum, Mónica Camila Toro Venegas, Michal Misiak, Richard M Ryan, Nora L Nock, Giovanni A Travaglino, Michael C Mensink, Gilad Feldman, Aaron L Wichman, Weilun Chou, Ignazio Ziano, Martin Seehuus, William J Chopik, Franki Y H Kung, Joelle Carpentier, Leigh Ann Vaughn, Hongfei Du, Qinyu Xiao, Tiago J S Lima, Chris Noone, Sandersan Onie, Frederick Verbruggen, Theda Radtke, Maximilian A Primbs
In response to the COVID-19 pandemic, the Psychological Science Accelerator coordinated three large-scale psychological studies to examine the effects of loss-gain framing, cognitive reappraisals, and autonomy framing manipulations on behavioral intentions and affective measures. The data collected (April to October 2020) included specific measures for each experimental study, a general questionnaire examining health prevention behaviors and COVID-19 experience, geographical and cultural context characterization, and demographic information for each participant...
February 11, 2023: Scientific Data
#17
JOURNAL ARTICLE
Adele Stewart, Gwynne L Davis, Lorena B Areal, Maximilian J Rabil, Vuong Tran, Felix P Mayer, Randy D Blakely
Identified across multiple psychiatric disorders, the dopamine (DA) transporter (DAT) Ala559Val substitution triggers non-vesicular, anomalous DA efflux (ADE), perturbing DA neurotransmission and behavior. We have shown that DAT Val559 mice display a waiting impulsivity and changes in cognitive performance associated with enhanced reward motivation. Here, utilizing a within-subject, lever-pressing paradigm designed to bias the formation of goal-directed or habitual behavior, we demonstrate that DAT Val559 mice modulate their nose poke behavior appropriately to match context, but demonstrate a perseverative checking behavior...
December 15, 2022: Cells
#18
JOURNAL ARTICLE
Felix P Mayer, Marco Niello, Daniela Cintulova, Spyridon Sideromenos, Julian Maier, Yang Li, Simon Bulling, Oliver Kudlacek, Klaus Schicker, Hideki Iwamoto, Fei Deng, Jinxia Wan, Marion Holy, Rania Katamish, Walter Sandtner, Yulong Li, Daniela D Pollak, Randy D Blakely, Marko D Mihovilovic, Michael H Baumann, Harald H Sitte
Increasing extracellular levels of serotonin (5-HT) in the brain ameliorates symptoms of depression and anxiety-related disorders, e.g., social phobias and post-traumatic stress disorder. Recent evidence from preclinical and clinical studies established the therapeutic potential of drugs inducing the release of 5-HT via the 5-HT-transporter. Nevertheless, current 5-HT releasing compounds under clinical investigation carry the risk for abuse and deleterious side effects. Here, we demonstrate that S-enantiomers of certain ring-substituted cathinones show preference for the release of 5-HT ex vivo and in vivo, and exert 5-HT-associated effects in preclinical behavioral models...
November 9, 2022: Molecular Psychiatry
#19
JOURNAL ARTICLE
Leonardo D Salgado, Blake E Wilson, Hannah J Penn, Randy T Richard, Michael O Way
Cultivar resistance is an essential management strategy for the Mexican rice borer, Eoreuma loftini (Dyar), in sugarcane in the USA, but resistance mechanisms are poorly understood. Resistance was evaluated among Louisiana's (USA) commercial sugarcane cultivars and experimental clones through field screenings, greenhouse trials, and a diet incorporation assay. Cultivars L 01-299 and HoCP 85-845 had the lowest borer injury levels, while HoCP 00-950 and L 12-201 were among the most heavily injured in field and greenhouse trials...
September 30, 2022: Insects
#20
JOURNAL ARTICLE
Charles A Dorison, Jennifer S Lerner, Blake H Heller, Alexander J Rothman, Ichiro I Kawachi, Ke Wang, Vaughan W Rees, Brian P Gill, Nancy Gibbs, Charles R Ebersole, Zahir Vally, Zuzanna Tajchman, Andras N Zsido, Mija Zrimsek, Zhang Chen, Ignazio Ziano, Zoi Gialitaki, Chris D Ceary, Yijun Lin, Yoshihiko Kunisato, Yuki Yamada, Qinyu Xiao, Xiaoming Jiang, Xinkai Du, Elvin Yao, John Paul Wilson, Wilson Cyrus-Lai, William Jimenez-Leal, Wilbert Law, W Matthew Collins, Karley L Richard, Marek Vranka, Vladislav Ankushev, Vidar Schei, Valerija Križanić, Veselina Hristova Kadreva, Vera Cubela Adoric, Ulrich S Tran, Siu Kit Yeung, Widad Hassan, Ralph Houston, Tiago J S Lima, Thomas Ostermann, Thomas Frizzo, Therese E Sverdrup, Thea House, Tripat Gill, Maksim Fedotov, Tamar Paltrow, Teodor Jernsäther, Maria Koptjevskaja-Tamm, Thomas J Hostler, Tatsunori Ishii, Barnabas Szaszi, Sylwia Adamus, Lilian Suter, Sumaiya Habib, Anna Studzinska, Dragana Stojanovska, Steve M J Janssen, Stefan Stieger, Stefan E Schulenberg, Srinivasan Tatachari, Soufian Azouaghe, Piotr Sorokowski, Agnieszka Sorokowska, Xin Song, Savannah C Lewis, Sladjana Sinkolova, Dmitry Grigoryev, Shira Meir Drexler, Shimrit Daches, Shawn N Geniole, Selena Vračar, Sébastien Massoni, Saša Zorjan, Eylül Sarıoğuz, Sara Morales Izquierdo, Sara G Alves, Sara Pöntinen, Sara Álvarez Solas, Santiago Ordoñez-Riaño, Sanja Batić Očovaj, Sandersan Onie, Samuel Lins, Sami Çoksan, Asli Sacakli, Susana Ruiz-Fernández, Sandra J Geiger, Saeideh FatahModares, Radoslaw B Walczak, Ruben Betlehem, Roosevelt Vilar, Rodrigo Cárcamo, Robert M Ross, Randy McCarthy, Tonia Ballantyne, Erin C Westgate, Reza Afhami, Dongning Ren, Renan P Monteiro, Ulf-Dietrich Reips, Niv Reggev, Robert J Calin-Jageman, Razieh Pourafshari, Raquel Oliveira, Mina Nedelcheva-Datsova, Rima-Maria Rahal, Rafael R Ribeiro, Theda Radtke, Rachel Searston, Redeate Habte, Przemysław Zdybek, Sau-Chin Chen, Princess Lovella G Maturan, Jennifer T Perillo, Peder Mortvedt Isager, Pavol Kačmár, Paulo Manuel Macapagal, Paulina Szwed, Paul H P Hanel, Paul A G Forbes, Patrícia Arriaga, Bastien Paris, Konstantinos Papachristopoulos, Pablo Sebastián Correa, Ondřej Kácha, Márcia Bernardo, Olatz Campos, Olalla Niño Bravo, Oscar J Galindo-Caballero, Chisom Esther Ogbonnaya, Olga Bialobrzeska, Natalia Kiselnikova, Nicolle Simonovic, Noga Cohen, Nora L Nock, Niklas Johannes, Nihan Albayrak-Aydemir, Nicolas Say, Nathan Torunsky, Natalia Van Doren, Naoyuki Sunami, Nikolay R Rachev, Nadyanna M Majeed, Nadya-Daniela Schmidt, Khaoula Nadif, Nadia S Corral-Frías, Nihal Ouherrou, Myrto Pantazi, Marc Y Lucas, Martin R Vasilev, María Victoria Ortiz, Muhammad Mussaffa Butt, Muhib Kabir, Rafał Muda, Maria Del Carmen Mc Tejada Rivera, Miroslav Sirota, Martin Seehuus, Michal Parzuchowski, Mónica Toro, Monika Hricova, Mónica Alarcón Maldonado, Magdalena Marszalek, Maria Karekla, Giovanna Mioni, Minke Jasmijn Bosma, Minja Westerlund, Milica Vdovic, Michal Bialek, Miguel A Silan, Michele Anne, Michal Misiak, Maurice Grinberg, Mariagrazia Capizzi, Mauricio F Espinoza Barría, Merve A Kurfali, Michael C Mensink, Mikayel Harutyunyan, Meetu Khosla, Max Korbmacher, Matúš Adamkovič, Matheus Fernando Felix Ribeiro, Maria Terskova, Matej Hruška, Marcel Martončik, Martin Voracek, Martin Čadek, Martha Frías-Armenta, Marta Kowal, Marta Topor, Marta Roczniewska, Marlies Oosterlinck, Markéta Braun Kohlová, Mariola Paruzel-Czachura, Marina Romanova, Marietta Papadatou-Pastou, Maria Louise Lund, Maria Antoniadi, Marc V Jones, Manuel S Ortiz, Mathi Manavalan, Abdumalik Muminov, Małgorzata Kossowska, Maja Friedemann, Magdalena Wielgus, Marco A C Varella, Melissa F Colloff, Maria Bradford, Leigh Ann Vaughn, Luis Eudave, Luc Vieira, Lina Maria Sanabria Pineda, Laura Calderón Pérez, Ljiljana B Lazarevic, Lisa M Jaremka, Elizaveta Kushnir, Lisa Anton-Boicuk, Gabriel Lins de Holanda Coelho, Lina Ahlgren, Carmel A Levitan, Leticia Micheli, Leonhard Volz, Marija Stojanovska, Leanne Boucher, Lara Samojlenko, Lady Grey Javela Delgado, Lada Kaliska, Lara Warmelink, Luis Miguel Rojas-Berscia, Karen Yu, Jakub Wachowicz, Kermeka Desai, Krystian Barzykowski, Luca Kozma, Kortnee Evans, Komila Kirgizova, Bamikole Emmanuel Agesin, Monica A Koehn, Kelly Wolfe, Tatiana Korobova, Kristoffer Klevjer, Kevin van Schie, Kevin Vezirian, Kaja Damnjanović, Katrine Krabbe Thommesen, Kathleen Schmidt, Katarzyna Filip, Karolina Grzech, Karlijn Hoyer, Karis Moon, Kafeel Rana, Kristina Janjić, Jordan W Suchow, Julita Kielińska, Julio E Cruz Vásquez, Julia Beitner, Juan Camilo Vargas-Nieto, Jose Carlos T Roxas, Jennifer Taber, Joan Urriago-Rayo, Jeffrey M Pavlacic, Jozef Bavolar, José A Soto, Jonas K Olofsson, Johannes K Vilsmeier, Johanna Messerschmidt, Johanna Czamanski-Cohen, Jordane Boudesseul, Jeong Min Lee, Julia Kamburidis, Janis Zickfeld, Jacob F Miranda, Jeroen P H Verharen, Evgeniya Hristova, Julie E Beshears, Jasna Milošević Đorđević, Jasmijn Bosch, Jaroslava Varella Valentova, 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The COVID-19 pandemic (and its aftermath) highlights a critical need to communicate health information effectively to the global public. Given that subtle differences in information framing can have meaningful effects on behavior, behavioral science research highlights a pressing question: Is it more effective to frame COVID-19 health messages in terms of potential losses (e.g., "If you do not practice these steps, you can endanger yourself and others") or potential gains (e.g., "If you practice these steps, you can protect yourself and others")? Collecting data in 48 languages from 15,929 participants in 84 countries, we experimentally tested the effects of message framing on COVID-19-related judgments, intentions, and feelings...
September 2022: Affective science
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