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Renal nutrition

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https://www.readbyqxmd.com/read/29906312/successful-treatment-of-chronic-hepatitis-c-infection-with-crushed-elbasvir-grazoprevir-administered-via-a-percutaneous-endoscopic-gastrostomy-tube
#1
J E Yap, P Jaiswal, L Ton, R Szynkarek, B M Attar, S Gandhi
WHAT IS KNOWN AND OBJECTIVE: Elbasvir/grazoprevir is an all-oral regimen approved for patients with hepatitis C virus (HCV) genotypes 1 and 4, and in renal insufficiency. However, to date, no data exist on the efficacy of this regimen when it is crushed and administered through a percutaneous endoscopic gastrostomy (PEG) tube. Here, we illustrate the case of a 63-year-old man who is the only known patient with HCV infection in the English literature to have successfully achieved a sustained viral response (SVR) when elbasvir/grazoprevir oral combination was administered through a PEG tube...
June 15, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29903644/high-parathyroid-hormone-levels-are-associated-with-osteosarcopenia-in-older-individuals-with-a-history-of-falling
#2
Pushpa Suriyaarachchi, Fernando Gomez, Carmen L Curcio, Derek Boersma, Lavanya Murthy, Vivian Grill, Gustavo Duque
OBJECTIVES: The combination of osteopenia/osteoporosis and sarcopenia (osteosarcopenia) defines a diagnostic subset of individuals at higher risk of falls, fractures and institutionalization. In this study we aimed to assess the potential role of high serum levels of parathyroid hormone (PTH) in osteosarcopenia. We hypothesized that a high PTH level is one of the major determinants of this syndrome. STUDY DESIGN: Cross-sectional study in 400 subjects (mean age = 79, 65% women) assessed between 2009 and 2014 at the Falls and Fractures Clinic, Nepean Hospital (Penrith, Australia)...
July 2018: Maturitas
https://www.readbyqxmd.com/read/29879890/pathophysiology-of-type-2-diabetes-in-children-and-adolescents
#3
Badhma Valaiyapathi, Barbara Gower, Ambika P Ashraf
BACKGROUND: The prevalence of type 2 diabetes (DM) in children is disturbingly increasing in parallel with increasing childhood obesity. Better knowledge regarding the pathophysiology of type 2 DM in children is paramount to devise an effective management plan. OBJECTIVE: Discuss the pathophysiology of type 2 DM in children and adolescents Methods and results: This is a comprehensive review of the literature on this topic. Type 2 DM in childhood is viewed as a continuum of insulin resistance (IR) which is determined by an underlying genetic predisposition, intrauterine environment, excessive food consumption, continued rapid weight gain, and poor lifestyle...
June 7, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/29872160/validation-of-thes-use-of-p-aminobenzoic-acid-to-determine-completeness-of-24-h-urine-collections-in-surveys-of-diet-and-nutrition
#4
Lorna Cox, Kate Guberg, Stephen Young, Sonja Nicholson, Toni Steer, Ann Prentice, Polly Page
Sodium intake is assessed using 24 h urinary excretion; it is important to ensure urine collections are complete. This can be validated by monitoring urinary excretion of p-aminobenzoic acid (PABA) administered in tablet form at intervals during the urine collection. Unavoidable change of PABA tablet supplier and analytical procedure required re-establishment of the thresholds consistent with a complete collection. Reference ranges for adults without reported intestinal or renal disease were determined by HPLC (70-103%) and colorimetry (84-120%)...
June 5, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29866494/noninvasive-evaluation-of-muscle-mass-by-ultrasonography-of-quadriceps-femoris-muscle-in-end-stage-renal-disease-patients-on-hemodialysis
#5
Alice Sabatino, Giuseppe Regolisti, Marco Delsante, Tommaso Di Motta, Chiara Cantarelli, Sarah Pioli, Giulia Grassi, Valentina Batini, Mariacristina Gregorini, Enrico Fiaccadori
BACKGROUND & AIMS: Protein-Energy Wasting (PEW) is a pathological condition of renal patients with advanced Chronic Kidney Disease characterized by a progressive reduction of energy and protein assets. Nutritional status assessment, especially for what concerns muscle mass, is essential for both the identification of patients at risk for the development of PEW, as well as monitoring the effects of nutritional interventions. Ultrasound methods are easily applicable at the bedside for quantitative assessment of skeletal muscle...
May 19, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29851070/probiotic-mitigates-the-toxic-effects-of-potassium-dichromate-in-preclinical-study-a-randomized-controlled-trial
#6
Soraia Younan, Gabriel Zanuto Sakita, João Gabriel Younan Coluna, Marcos Natal Rufino, Rogéria Keller, Hermann Bremer-Neto
BACKGROUND: The objective of this study was to evaluate the nutritional, physiological, and biochemical effects of dietary supplementation of an association of probiotic bacteria in rats intoxicated with chromium (VI). Ninety-six male rats, recently weaned, were randomly divided into 8 groups (n=12): Control, DK12, DK24, and DK36 (0, 0.12, 0.24, and 0.36 g.kg-1 of K2 Cr2 O7 incorporated in the basal feed, respectively) and groups Prob, DK12+Prob, DK24+Prob, and DK36+Prob received a progressive dose of 0, 0...
May 30, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29842852/the-modifying-effect-of-kidney-function-on-the-association-of-cadmium-exposure-with-blood-pressure-and-cardiovascular-mortality-nhanes-1999-2010
#7
Yi Gao, Xiangzhu Zhu, Martha J Shrubsole, Lei Fan, Zhaolin Xia, Raymond C Harris, Lifang Hou, Qi Dai
OBJECTIVE: We hypothesized that the associations of urinary Cd with blood pressure and cardiovascular disease (CVD) mortality may be modified by renal function. METHODS: We tested these hypotheses using data from the National Health and Nutrition Examination Survey (NHANES, 1999-2000. RESULTS: Both systolic blood pressure (SBP) and diastolic blood pressure (DBP) were positively associated with blood Cd. DBP was positively related to urinary Cd whereas SBP was inversely associated with urinary Cd...
May 26, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29808451/an-update-on-calciphylaxis
#8
REVIEW
José Alberto García-Lozano, Jorge Ocampo-Candiani, Sylvia Aide Martínez-Cabriales, Verónica Garza-Rodríguez
Calciphylaxis, also known as calcific uremic arteriolopathy and uremic small artery disease with medial wall calcification and intimal hyperplasia, is a multifactorial cutaneous vascular disease characterized by chronic, painful, non-healing wounds that occur frequently in patients with chronic kidney disease, predominantly in those with end-stage renal disease. The pathogenesis remains unclear, and the development of calciphylaxis lesions depends on medial calcification, intimal fibrosis of arterioles and thrombotic occlusion...
May 28, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29807979/impact-of-preoperative-abdominal-visceral-adipose-tissue-area-and-nutritional-status-on-renal-function-after-donor-nephrectomy-in-japanese-living-donors-for-renal-transplantation
#9
Shunta Hori, Makito Miyake, Yosuke Morizawa, Yasushi Nakai, Kenta Onishi, Kota Iida, Daisuke Gotoh, Satoshi Anai, Kazumasa Torimoto, Katsuya Aoki, Tatsuo Yoneda, Nobumichi Tanaka, Katsunori Yoshida, Kiyohide Fujimoto
BACKGROUND Living kidney donors face the risk of renal dysfunction, resulting in end-stage renal disease, cardiovascular disease, or cerebrovascular disease, after donor nephrectomy. Reducing this risk is important to increasing survival of living donors. In this study, we investigated the effect of preoperative distribution of abdominal adipose tissue and nutritional status on postoperative renal function in living donors. MATERIAL AND METHODS Seventy-five living donors were enrolled in this retrospective study...
May 29, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29805542/increased-prevalence-of-peripheral-arterial-disease-in-patients-with-obese-sarcopenia-undergoing-hemodialysis
#10
Shun-Li Tian, Kai Zhang, Peng-Cheng Xu
Background peripheral arterial disease (PAD) is a common complication in patients undergoing dialysis, which reduces the quality of life and increases the risk of mortality. Recent literature has documented an association between increased visceral fat (VF) content and a proatherogenic factors in end-stage renal disease. The present study investigated the prevalence of PAD in patients undergoing hemodialysis. PAD was determined as an ankle-brachial index <0.9. Additionally, VF content was determined using multiple frequency bioelectrical impendence analysis...
June 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29802078/the-role-of-extra-pancreatic-infections-in-the-prediction-of-severity-and-local-complications-in-acute-pancreatitis
#11
Elizabeth Pando, Piero Alberti, Jimmy Hidalgo, Laura Vidal, Cristina Dopazo, Mireia Caralt, Laia Blanco, Concepción Gómez-Gavara, Itxarone Bilbao, Joaquim Balsells, Ramon Charco
BACKGROUND: The aim of our study was to determine the risk factors for extrapancreatic infection (EPI) occurrence and its predictive power for assessing severity and local complications in acute pancreatitis including infected pancreatic necrosis (IPN). METHODS: Clinical data of 176 AP patients prospectively enrolled were analysed. EPI analysed were bacteraemia, lung infection, urinary tract infection and catheter line infection. Risk factors analysed were: Leukocyte count, C-reactive protein, liver function test, serum calcium, serum glucose, Blood urea nitrogen, mean arterial pressure at admission, total parenteral nutrition (TPN), enteral nutrition, hypotension, respiratory, cardiovascular and renal failure at admission, persistent systemic inflammatory response (SIRS) and intrapancreatic necrosis...
May 19, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29801446/the-protocol-of-a-population-based-prospective-cohort-study-in-southwest-of-iran-to-analyze-common-non-communicable-diseases-shahrekord-cohort-study
#12
Arsalan Khaledifar, Morteza Hashemzadeh, Kamal Solati, Hosseion Poustchi, Valentina Bollati, Ali Ahmadi, Soleiman Kheiri, Keihan Ghatreh Samani, Mehdi Banitalebi, Morteza Sedehi, Reza Malekzadeh
BACKGROUND: Prospective cohort studies are considered ideal choices to study multiple outcomes and risk factors for Non-communicable diseases (NCDs). Our aim is to set-up the protocol and analyze risk factors, incidence rates, prevalence, trends, and the models of environmental and genetic determinants of NCDs and their outcomes as well as interaction among such determinants. METHODS: Shahrekord cohort study (SCS) that is a population-based prospective, study on a cohort consisting of people aged 35-70 years started in November 2015 in Iran...
May 25, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29797662/autologous-peripheral-blood-stem-cell-transplantation-in-dialysis-dependent-multiple-myeloma-patients-dautos-study-of-the-polish-myeloma-study-group
#13
Anna Waszczuk-Gajda, Zbigniew Lewandowski, Joanna Drozd-Sokołowska, Piotr Boguradzki, Jarosław Dybko, Tomasz Wróbel, Grzegorz Władysław Basak, Artur Jurczyszyn, Krzysztof Madry, Emilian Snarski, Ewa Frączak, Grzegorz Charliński, Magdalena Feliksbrot-Bratosiewicz, Małgorzata Król, Joanna Matuszkiewicz-Rowińska, Marian Klinger, Magdalena Krajewska, Hanna Augustyniak-Bartosik, Małgorzata Kościelska, Patrycja Rusicka, Jadwiga Dwilewicz-Trojaczek, Wieslaw Wiktor Jedrzejczak
Dialysis dependent (DD) multiple myeloma patients (MM) have a poor prognosis and high tumour burden, thus may benefit from autologous peripheral blood stem cell transplantation (auto-PBSCT), however, these patients have an increased risk of toxicity. AIMS: To evaluate the outcomes (toxicity, PFS, OS) of high dose therapy followed by auto-PBSCT during an observational study and after propensity score matching. PATIENTS AND METHODS: Between 2004-2015, 24 DD patients, (aged 38-67 yrs), ISS 3, treated with auto-PBSCT, requiring dialysis at diagnosis and auto-PBSCT were evaluated, matched and compared to 55 normal renal function MM patients (NRF) with ISS 3 for outcomes of interest...
May 24, 2018: European Journal of Haematology
https://www.readbyqxmd.com/read/29797247/nutritional-treatment-of-advanced-ckd-twenty-consensus-statements
#14
Adamasco Cupisti, Giuliano Brunori, Biagio Raffaele Di Iorio, Claudia D'Alessandro, Franca Pasticci, Carmela Cosola, Vincenzo Bellizzi, Piergiorgio Bolasco, Alessandro Capitanini, Anna Laura Fantuzzi, Annalisa Gennari, Giorgina Barbara Piccoli, Giuseppe Quintaliani, Mario Salomone, Massimo Sandrini, Domenico Santoro, Patrizia Babini, Enrico Fiaccadori, Giovanni Gambaro, Giacomo Garibotto, Mariacristina Gregorini, Marcora Mandreoli, Roberto Minutolo, Giovanni Cancarini, Giuseppe Conte, Francesco Locatelli, Loreto Gesualdo
The Italian nephrology has a long tradition and experience in the field of dietetic-nutritional therapy (DNT), which is an important component in the conservative management of the patient suffering from a chronic kidney disease, which precedes and integrates the pharmacological therapies. The objectives of DNT include the maintenance of an optimal nutritional status, the prevention and/or correction of signs, symptoms and complications of chronic renal failure and, possibly, the delay in starting of dialysis...
May 24, 2018: Journal of Nephrology
https://www.readbyqxmd.com/read/29796583/influence-of-nutritional-status-laboratory-parameters-and-dietary-patterns-upon-urinary-acid-excretion-in-calcium-stone-formers
#15
Carolini Zanette Warmling Tessaro, Christiane Ishikawa Ramos, Ita Pfeferman Heilberg
INTRODUCTION: Obesity and Metabolic Syndrome (MS) are associated with low urinary pH and represent risk factors for nephrolithiasis, especially composed by uric acid. Acidogenic diets may also contribute to a reduction of urinary pH. Propensity for calcium oxalate precipitation has been shown to be higher with increasing features of the MS. OBJECTIVE: A retrospective evaluation of anthropometric and body composition parameters, MS criteria and the dietary patterns of overweight and obese calcium stone formers and their impact upon urinary pH and other lithogenic parameters was performed...
January 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29790110/prevalence-of-hyperuricemia-and-its-associated-factors-in-the-general-korean-population-an-analysis-of-a-population-based-nationally-representative-sample
#16
Yunkyung Kim, Jihun Kang, Geun-Tae Kim
Hyperuricemia is not only a risk factor for gout but also an independent determinant of hypertension, diabetes, and chronic kidney diseases. Although the incidence of gout in Korean adults is increasing, epidemiologic studies on hyperuricemia in the general Korean population are limited. Thus, this study aimed at evaluating the prevalence of hyperuricemia and its associated factors among non-institutionalized Korean adults. The present study included 5548 participants (2403 men and 3145 women) aged ≥ 19 years from The Korea National Health and Nutrition Examination Survey...
May 23, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29789798/the-relation-between-sarcopenia-and-mortality-in-patients-at-intensive-care-unit
#17
Mehmet Toptas, Mazhar Yalcin, İbrahim Akkoc, Eren Demir, Cagatay Metin, Yildiray Savas, Muhsin Kalyoncuoglu, Mehmet Mustafa Can
Background and Aim: Psoas muscle area (PMA) can reflect the status of skeletal muscle in the whole body. It has been also reported that decreased PMA was associated with postoperative mortality or morbidity after several surgical procedures. In this study, we aimed to investigate the relation between PMA and mortality in all age groups in intensive care unit (UNIT). Materials and Method: The study consists of 362 consecutive patients. The demographic characteristics of patients, indications for ICU hospitalization, laboratory parameters, and clinical parameters consist of mortality and length of stay, and surgery history was obtained from intensive care archive records...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29789348/gestational-low-protein-intake-enhances-whole-kidney-mir-192-and-mir-200-family-expression-and-epithelial-to-mesenchymal-transition-in-rat-adult-male-offspring
#18
Letícia B Sene, Victor Hugo Gonçalves Rizzi, José A R Gontijo, Patricia A Boer
Studies have shown that adult offspring of mothers fed a protein-restricted diet during pregnancy present a pronounced reduction of nephron number associated with decreased fractional urinary sodium excretion and arterial hypertension. Additionally, recent advances in our understanding of the molecular pathways that govern the association of gestational nutritional restriction, intrauterine growth retardation and inflammation with impaired nephrogenesis, nephron underdosing and kidney fibrosis point to the epithelial to mesenchymal transition (EMT) as a common factor...
May 22, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29777844/angioplasty-for-budd-chiari-syndrome-in-a-child-with-26-year-follow-up
#19
Xixiang Gao, Zhu Tong, Lianrui Guo, Jianxin Li, Jian Zhang, Yongquan Gu
Budd-Chiari syndrome (BCS) is a rare but life-threatening disease. If not treated promptly, it is almost always lethal of progressive liver failure, severe nutritional depletion, and renal failure at the late stage. We report the successful treatment of a 5-year-old boy with BCS due to a stenosis of the IVC with a 26-year follow-up. We performed percutaneous transluminal angioplasty (PTA), which resulted in a great improvement of BCS, and the disappearance of ascites. Restenosis occurred at 25 years after the initial angioplasty, for which balloon angioplasty was repeatedly performed...
May 16, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29777456/distal-bowel-re-feeding-in-patients-with-proximal-jejunostomy
#20
Anand Nagar, Siddharth Mehrotra, Amitabh Yadav, Vivek Mangla, Shailendra Lalwani, Naimish Mehta, Samiran Nundy
BACKGROUND: Patients who have a proximal jejunostomy are difficult to manage because of their high stoma output which results in fluid and electrolyte imbalance with repeated hospital admissions and the necessity for expensive parenteral nutrition (PN). There are few reports on the use of re-feeding of the proximal effluents in this situation. METHODS: We here relate our experience with this manoeuvre in 35 patients between Jan 2010 and Feb 2016 who had stomas less than 120 cm away from the duodenojejunal flexure...
May 18, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
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