keyword
MENU ▼
Read by QxMD icon Read
search

Basal Forebrain

keyword
https://www.readbyqxmd.com/read/29140731/recovery-of-an-injured-cingulum-concurrent-with-improvement-of-short-term-memory-in-a-patient-with-mild-traumatic-brain-injury
#1
Sung Ho Jang, Seong Ho Kim, Jeong Pyo Seo
OBJECTIVES: We reported on a patient with mild traumatic brain injury (TBI) who showed recovery of an injured cingulum concurrent with improvement of short-term memory, which was demonstrated on follow-up diffusion tensor tractography (DTT). METHODS: A 55-year-old male patient suffered head trauma resulting from falling from approximately 2 m while working at a construction site. The patient showed mild memory impairment (especially short-term memory impairment) at 3 months after onset: Memory Assessment Scale (global memory: 95 (37%ile), short-term memory: 75 (5%ile), verbal memory: 80 (9%ile) and visual memory: 112 (79%ile))...
November 15, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29137029/neural-reorganization-between-injured-cingula-and-the-brainstem-cholinergic-nuclei-in-a-patient-with-cerebral-concussion-a-case-report
#2
Sung Ho Jang, Young Hyeon Kwon
RATIONALE: We report on a patient who showed neural reorganization between injured cingula and the brainstem cholinergic nuclei following cerebral concussion. PATIENT CONCERNS: The main concern of the patient is memory impairment. DIAGNOSES: Cerebral concussion. OUTCOMES: When she visited our hospital at 2 years after onset, cognitive function was evaluated using 2 scales; the Wechsler Intelligence Scale, and the Seoul neuropsychological screening battery: total IQ 97, verbal immediate recall 5...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29107476/the-blueprint-of-the-vertebrate-forebrain-with-special-reference-to-the-habenulae
#3
REVIEW
Sten Grillner, Arndt von Twickel, Brita Robertson
The medial and lateral habenulae are conserved throughout vertebrate evolution, and form an integrated part in the forebrain control of behavior together with the basal ganglia, the dopamine and serotonin systems and cortex. The lateral habenula plays a role in the control of dopamine activity in the context of aversive behavior and the converse, a reward situation. These circuits are important for a value-based evaluation of the success of prior actions. The medial habenula is involved in mediating escape and freezing behavior...
October 26, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29098547/new-data-from-pdfgb-ret-ret-mutant-mice-might-lead-to-a-paradoxical-association-between-brain-calcification-pericytes-recruitment-and-bbb-integrity
#4
Denis A P Moura, Roberta R Lemos, João R M Oliveira
Data of mice with PDGF-B-truncating mutation (Pdgfb (ret/ret)) from different research groups indicate that the malfunction of this protein leads to reduced pericyte recruitment, loss of Blood-Brain Barrier (BBB) integrity and bilateral brain calcification. This makes these mice important models for Primary Brain Calcification and pericyte-BBB correlation studies. The global brain pericyte count is reduced in Pdgfb (ret/ret) mice, with higher BBB permeability. We have overlapped the data from other research groups into a figure to further analyze the findings...
November 2, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29094303/high-thickness-histological-sections-as-alternative-to-study-the-three-dimensional-microscopic-human-sub-cortical-neuroanatomy
#5
Eduardo Joaquim Lopes Alho, Ana Tereza Di Lorenzo Alho, Lea Grinberg, Edson Amaro, Gláucia Aparecida Bento Dos Santos, Rafael Emídio da Silva, Ricardo Caires Neves, Maryana Alegro, Daniel Boari Coelho, Manoel Jacobsen Teixeira, Erich Talamoni Fonoff, Helmut Heinsen
Stereotaxy is based on the precise image-guided spatial localization of targets within the human brain. Even with the recent advances in MRI technology, histological examination renders different (and complementary) information of the nervous tissue. Although several maps have been selected as a basis for correlating imaging results with the anatomical locations of sub-cortical structures, technical limitations interfere in a point-to-point correlation between imaging and anatomy due to the lack of precise correction for post-mortem tissue deformations caused by tissue fixation and processing...
November 1, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/29078805/crispr-cas9-correctable-mutation-related-molecular-and-physiological-phenotypes-in-ipsc-derived-alzheimer-s-psen2-n141i-neurons
#6
Maitane Ortiz-Virumbrales, Cesar L Moreno, Ilya Kruglikov, Paula Marazuela, Andrew Sproul, Samson Jacob, Matthew Zimmer, Daniel Paull, Bin Zhang, Eric E Schadt, Michelle E Ehrlich, Rudolph E Tanzi, Ottavio Arancio, Scott Noggle, Sam Gandy
Basal forebrain cholinergic neurons (BFCNs) are believed to be one of the first cell types to be affected in all forms of AD, and their dysfunction is clinically correlated with impaired short-term memory formation and retrieval. We present an optimized in vitro protocol to generate human BFCNs from iPSCs, using cell lines from presenilin 2 (PSEN2) mutation carriers and controls. As expected, cell lines harboring the PSEN2 (N141I) mutation displayed an increase in the Aβ42/40 in iPSC-derived BFCNs. Neurons derived from PSEN2 (N141I) lines generated fewer maximum number of spikes in response to a square depolarizing current injection...
October 27, 2017: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/29038219/the-l-type-voltage-gated-calcium-channel-cav1-2-mediates-fear-extinction-and-modulates-synaptic-tone-in-the-lateral-amygdala
#7
Stephanie J Temme, Geoffrey G Murphy
L-type voltage-gated calcium channels (LVGCCs) have been implicated in both the formation and the reduction of fear through Pavlovian fear conditioning and extinction. Despite the implication of LVGCCs in fear learning and extinction, studies of the individual LVGCC subtypes, CaV1.2 and CaV1.3, using transgenic mice have failed to find a role of either subtype in fear extinction. This discontinuity between the pharmacological studies of LVGCCs and the studies investigating individual subtype contributions could be due to the limited neuronal deletion pattern of the CaV1...
November 2017: Learning & Memory
https://www.readbyqxmd.com/read/29033787/a-novel-ex-vivo-model-to-investigate-the-underlying-mechanisms-in-alzheimer-s-disease
#8
Emanuele Brai, Skye Stuart, Antoine-Scott Badin, Susan A Greenfield
Currently there is no widely accepted animal model reproducing the full pathological profile of Alzheimer's disease (AD), since the basic mechanisms of neurodegeneration are still poorly understood. We have proposed that the interaction between the α7 nicotinic acetylcholine receptor (α7-nAChR) and a recently discovered toxic peptide, cleaved from the acetylcholinesterase (AChE) C-terminus, could account for the aberrant processes occurring in AD. In this article we describe a new application on ex vivo model procedure, which combines the advantages of both in vivo and in vitro preparations, to study the effects of the AChE-derived peptide on the rat basal forebrain (BF)...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28984594/alzheimer-s-disease-the-alternative-serotonergic-hypothesis-of-cognitive-decline
#9
Costa Vakalopoulos
The pathognomonic feature of Alzheimer's disease is a loss of declarative memory. This has generally been attributed to early involvement of medial temporal lobe structures with neurofibrillary tangles and loss of neurons in the entorhinal cortex. However, there has been a re-emerging emphasis on the causal role of brainstem monoaminergic nuclei as involvement of the cholinergic basal forebrain loses prominence. The rejection of this latter theory of cognitive decline is related to inconsistencies in time course and modest effects of treatment using cholinergic agents...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28959191/distinct-temporal-coordination-of-spontaneous-population-activity-between-basal-forebrain-and-auditory-cortex
#10
Josue G Yague, Tomomi Tsunematsu, Shuzo Sakata
The basal forebrain (BF) has long been implicated in attention, learning and memory, and recent studies have established a causal relationship between artificial BF activation and arousal. However, neural ensemble dynamics in the BF still remains unclear. Here, recording neural population activity in the BF and comparing it with simultaneously recorded cortical population under both anesthetized and unanesthetized conditions, we investigate the difference in the structure of spontaneous population activity between the BF and the auditory cortex (AC) in mice...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28956328/current-understanding-of-pde10a-in-the-modulation-of-basal-ganglia-circuitry
#11
Jan-Philip Schülke, Nicholas J Brandon
The basal ganglia are a forebrain network of interconnected nuclei that are involved in action selection, reward circuits and coordinating movement. PDE10A inhibition has been proposed as a novel way to modulate basal ganglia circuitry and to ameliorate symptoms in Huntington's disease, Parkinson's disease and Schizophrenia. However, despite encouraging results from pre-clinical models, PDE10A inhibitors failed to show efficacy as an antipsychotic in several clinical trials. PDE10A is expressed in the medium spiny neurons of the striatum and works to limit cyclic nucleotide signaling in response to modulatory neurotransmitters like dopamine...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28935940/layer-and-cell-type-selective-co-transmission-by-a-basal-forebrain-cholinergic-projection-to-the-olfactory-bulb
#12
Daniel T Case, Shawn D Burton, Jeremy Y Gedeon, Sean-Paul G Williams, Nathaniel N Urban, Rebecca P Seal
Cholinergic neurons in the basal forebrain project heavily to the main olfactory bulb, the first processing station in the olfactory pathway. The projections innervate multiple layers of the main olfactory bulb and strongly influence odor discrimination, detection, and learning. The precise underlying circuitry of this cholinergic input to the main olfactory bulb remains unclear, however. Here, we identify a specific basal forebrain cholinergic projection that innervates select neurons concentrated in the internal plexiform layer of the main olfactory bulb...
September 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28921744/cholinergic-basal-forebrain-structures-are-not-essential-for-mediation-of-the-arousing-action-of-glutamate
#13
Zoltán Lelkes, Shamsiiat Abdurakhmanova, Tarja Porkka-Heiskanen
The cholinergic basal forebrain contributes to cortical activation and receives rich innervations from the ascending activating system. It is involved in the mediation of the arousing actions of noradrenaline and histamine. Glutamatergic stimulation in the basal forebrain results in cortical acetylcholine release and suppression of sleep. However, it is not known to what extent the cholinergic versus non-cholinergic basal forebrain projection neurones contribute to the arousing action of glutamate. To clarify this question, we administered N-methyl-D-aspartate (NMDA), a glutamate agonist, into the basal forebrain in intact rats and after destruction of the cholinergic cells in the basal forebrain with 192 immunoglobulin (Ig)G-saporin...
September 18, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28916821/reduced-basal-forebrain-atrophy-progression-in-a-randomized-donepezil-trial-in-prodromal-alzheimer-s-disease
#14
Enrica Cavedo, Michel J Grothe, Olivier Colliot, Simone Lista, Marie Chupin, Didier Dormont, Marion Houot, Stephane Lehéricy, Stefan Teipel, Bruno Dubois, Harald Hampel
Acetylcholinesterase inhibitors are approved drugs currently used for the treatment of Alzheimer's disease (AD) dementia. Basal forebrain cholinergic system (BFCS) atrophy is reported to precede both entorhinal cortex atrophy and memory impairment in AD, challenging the traditional model of the temporal sequence of topographical pathology associated with AD. We studied the effect of one-year Donepezil treatment on the rate of BFCS atrophy in prodromal AD patients using a double-blind, randomized, placebo-controlled trial of Donepezil (10 mg/day)...
September 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28891447/potential-role-of-neuroimaging-markers-for-early-diagnosis-of-dementia-in-primary-care
#15
Stefan Teipel, Ingo Kilimann, Jochen R Thyrian, Stefan Klöppel, Wolfgang Hoffmann
BACKGROUND: The use of imaging markers for the diagnosis of predementia and early dementia stages of Alzheimer's disease (AD) has widely been explored in research settings and specialized care. The use of these markers in primary care has yet to be established. OBJECTIVE: Summarize current evidence for the usefulness of imaging markers for AD in primary compared to specialized care settings. METHOD: Selective overview of the literature, and pilot data on the use of MRI-based hippocampus and basal forebrain volumetry for the discrimination of AD dementia and mild cognitive impairment (MCI) cases from healthy controls in 58 cases from a primary care cohort and 58 matched cases from a memory clinic's sample...
September 7, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28887225/substance-p-and-neurotensin-in-the-limbic-system-their-roles-in-reinforcement-and-memory-consolidation
#16
REVIEW
L Lénárd, K László, E Kertes, T Ollmann, L Péczely, A Kovács, V Kállai, O Zagorácz, R Gálosi, Z Karádi
Substance P (SP) and neurotensin (NT) are neuropeptides isolated in the periphery and in the central nervous system. They are involved in various regulatory processes in the gastrointestinal tract, in the circulatory and respiratory systems, kidney and endocrine system. In addition to the peripheral effects, SP and NT act as neurotransmitters and neuromodulators in the central nervous system, regulating various behavioural actions, such as general and motor activity, pain, food and water intake, anxiety, reward/reinforcement and memory consolidation...
September 5, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28884145/sensory-experience-shapes-the-integration-of-adult-born-neurons-into-the-olfactory-bulb
#17
Elizabeth Hanson, Jessica Swanson, Benjamin R Arenkiel
Olfaction is an ancient sensory modality which is heavily involved in viscerally-important tasks like finding food and identifying mates. Olfactory processing involves interpreting stimuli from a non-continuous odor space, and translating them into an organized pattern of neuronal activity in the olfactory bulb. Additionally, olfactory processing is rapidly modulated by behavioral states and vice versa. This implies strong bidirectional neuromodulation between the olfactory bulb and other brain regions that include the cortex, hippocampus, and basal forebrain...
August 2017: Journal of Nature and Science
https://www.readbyqxmd.com/read/28874448/glycinergic-input-to-the-mouse-basal-forebrain-cholinergic-neurons
#18
Zsuzsanna Bardóczi, Balázs Pál, Áron Kőszeghy, Tamás Wilheim, Masahiko Watanabe, László Záborszky, Zsolt Liposits, Imre Kalló
The basal forebrain (BF) receives afferents from brainstem ascending pathways, which has been implicated first by Moruzzi and Magoun (1949) to induce forebrain activation and cortical arousal/waking behavior; however, it is very little known about how brainstem inhibitory inputs affect cholinergic functions. In the current study, glycine, a major inhibitory neurotransmitter of brainstem neurons, and gliotransmitter of local glial cells, was tested for potential interaction with BF cholinergic (BFC) neurons in male mice...
September 27, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28827178/increase-in-cortical-endocannabinoid-signaling-in-a-rat-model-of-basal-forebrain-cholinergic-dysfunction
#19
Alberto Llorente-Ovejero, Iván Manuel, Maria Teresa Giralt, Rafael Rodríguez-Puertas
The basal forebrain cholinergic pathways progressively degenerate during the progression of Alzheimer's disease, leading to an irreversible impairment of memory and thinking skills. The stereotaxic lesion with 192IgG-saporin in the rat brain has been used to eliminate basal forebrain cholinergic neurons and is aimed at emulating the cognitive damage described in this disease in order to explore its effects on behavior and on neurotransmission. Learning and memory processes that are controlled by cholinergic neurotransmission are also modulated by the endocannabinoid (eCB) system...
August 18, 2017: Neuroscience
https://www.readbyqxmd.com/read/28821666/gabaergic-interneuron-differentiation-in-the-basal-forebrain-is-mediated-through-direct-regulation-of-glutamic-acid-decarboxylase-isoforms-by-dlx-homeobox-transcription-factors
#20
Trung N Le, Qing-Ping Zhou, Inma Cobos, Shunzhen Zhang, Jamie Zagozewski, Sara Japoni, Jerry Vriend, Tracie Parkinson, Guoyan Du, John L Rubenstein, David D Eisenstat
GABA is the key inhibitory neurotransmitter in the cortex but regulation of its synthesis during forebrain development is poorly understood. In the telencephalon, members of the distal-less (Dlx) homeobox gene family are expressed in, and regulate the development of, the basal ganglia primodia from which many GABAergic neurons originate and migrate to other forebrain regions. The Dlx1/Dlx2 double knock-out mice die at birth with abnormal cortical development, including loss of tangential migration of GABAergic inhibitory interneurons to the neocortex (Anderson et al...
September 6, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
keyword
keyword
21044
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"