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Low protein diet

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https://www.readbyqxmd.com/read/29454073/the-accumulation-of-assembly-intermediates-of-the-mitochondrial-complex-i-matrix-arm-is-reduced-by-limiting-glucose-uptake-in-a-neuronal-like-model-of-melas-syndrome
#1
Guillaume Geffroy, Rayane Benyahia, Samuel Frey, Valerie Desquiret-Dumas, Naig Gueguen, Celine Bris, Sophie Belal, Aurore Inisan, Aurelie Renaud, Arnaud Chevrollier, Daniel Henrion, Dominique Bonneau, Franck Letournel, Guy Lenaers, Pascal Reynier, Vincent Procaccio
Ketogenic diet (KD) which combined carbohydrate restriction and the addition of ketone bodies has emerged as an alternative metabolic intervention used as an anticonvulsant therapy or to treat different types of neurological or mitochondrial disorders including MELAS syndrome. MELAS syndrome is a severe mitochondrial disease mainly due to the m.3243A > G mitochondrial DNA mutation. The broad success of KD is due to multiple beneficial mechanisms with distinct effects of very low carbohydrates and ketones...
February 14, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29453556/effects-of-increasing-dietary-protein-supplies-on-milk-yield-milk-composition-and-nitrogen-use-efficiency-in-lactating-buffalo
#2
Muhammad Naveed-Ul-Haque, Muhammad Uzair Akhtar, Rizwan Munnawar, Saba Anwar, Anjum Khalique, Murtaza Ali Tipu, Fayyaz Ahmad, Muhammad Qamer Shahid
Nitrogen efficiency of lactating buffalo can be increased by providing dietary crude protein (CP) precisely to the requirement. Twelve lactating Nili-Ravi buffaloes (6 primiparous and 6 multiparous) at 76 ± 37.5 days in milk (DIM) were used in this study. The treatments were diets providing three levels of CP (% DM basis): (1) low-protein = 11%; (2) medium-protein = 13.1%; (3) high-protein = 14.2% according to a 3 × 3 Latin square design. The period length of each treatment was 21 days and the total duration of experiment was 63 days...
February 16, 2018: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29452888/could-low-protein-diet-modulate-nrf2-pathway-in-chronic-kidney-disease
#3
REVIEW
Juliana Saraiva Anjos, Ludmila F M F Cardozo, Marta Esgalhado, Bengt Lindholm, Peter Stenvinkel, Denis Fouque, Denise Mafra
Oxidative stress and inflammation are common findings in chronic kidney disease (CKD) patients, and they are directly linked to clinical outcomes such as protein energy wasting and cardiovascular disease. Nuclear factor-erythroid 2-related factor 2 (Nrf2) is the master regulator of antioxidant genes, regulating the expression of detoxifying enzymes of phase II and antioxidant responses. Furthermore, Nrf2 can also regulate anti-inflammatory cellular responses, by inhibiting nuclear factor kappa B activity (transcription factor that promotes inflammation)...
February 13, 2018: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29446933/dietary-sodium-butyrate-supplementation-reduces-high-concentrate-diet-feeding-induced-apoptosis-in-mammary-cells-in-dairy-goats
#4
Guangjun Chang, Jinyu Yan, Nana Ma, Xinxin Liu, Hongyu Dai, Muhammad Shaid Bilal, Xiangzhen Shen
Eighteen lactating goats (38.86 ± 2.06 kg) were randomly allocated to three groups. One group was fed a low-concentrate (LC) diet (forage:concentrate = 6:4, LC), while the other two groups were fed a high-concentrate (HC) diet (forage:concentrate = 4:6, HC) or an HC diet supplemented with sodium butyrate (BHC) for 20 weeks. Samples of ruminal fluid, milk, hepatic blood plasma, and mammary gland tissue were prepared for the experimental analysis. The LPS concentration, caspase-3 and -8 enzymatic activity, caspase-3 and -8 mRNA expression, and NF-κB (p65), phosphorylated-p65, bax, cytochrome C, and caspase-3 protein expression were higher in the HC group than those in the LC group; however, the levels of these parameters were lower in the BHC group than those in the HC group...
February 15, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29446245/differential-metabolic-effects-of-constant-moderate-versus-high-intensity-interval-training-in-high-fat-fed-mice-possible-role-of-muscle-adiponectin
#5
Sergio F Martinez-Huenchullan, Babu Raja Maharjan, Paul F Williams, Charmaine S Tam, Susan V Mclennan, Stephen M Twigg
Exercise regimens may have differing effects in the presence of obesity. In addition to being fat derived, adiponectin has recently been described as a myokine that regulates insulin sensitivity, which may link to exercise-related metabolic benefits in obesity. Whether skeletal muscle adiponectin varies in different exercise modalities is unclear. This study investigated the comparative effects of 10 weeks of endurance constant-moderate intensity exercise (END) with high intensity interval training (HIIT), on metabolic outcomes, including muscle adiponectin in a mouse model of diet-induced obesity...
February 2018: Physiological Reports
https://www.readbyqxmd.com/read/29444098/integrating-nutrient-bioavailability-and-co-production-links-when-identifying-sustainable-diets-how-low-should-we-reduce-meat-consumption
#6
Tangui Barré, Marlène Perignon, Rozenn Gazan, Florent Vieux, Valérie Micard, Marie-Josèphe Amiot, Nicole Darmon
BACKGROUND: Reducing the consumption of meat and other animal-based products is widely advocated to improve the sustainability of diets in high-income countries. However, such reduction may impair nutritional adequacy, since the bioavailability of key nutrients is higher when they come from animal- vs plant-based foods. Meat reduction may also affect the balance between foods co-produced within the same animal production system. OBJECTIVE: The objective was to assess the impact of introducing nutrient bioavailability and co-production links considerations on the dietary changes needed - especially regarding meat ‒ to improve diet sustainability...
2018: PloS One
https://www.readbyqxmd.com/read/29442728/inhibition-of-p53-relieves-insulin-resistance-in-fetal-growth-restriction-mice-with-catch-up-growth-via-activating-igfbp3-igf-1-irs-1-akt-signaling-pathway
#7
Ping Peng, Chunling Ma, Shumei Wan, Wensheng Jin, Yan Gao, Tianqing Huang, Qi Cheng, Changlan Ye
To investigate insulin resistance of the fetal growth restriction (FGR) mice with catch-up growth (CUG) and the underlying mechanism, in this study, low protein diet was used during pregnancy to establish the FGR mice model, and high fat diet was applied to establish the CUG model of FGR mice. The insulin and Pifithrin-α stimulation was performed via intraperitoneal injection. The physical characters, biochemical parameters, expression of related molecules in each group were detected via ELISA, RT-PCR, WB, etc...
June 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29439931/does-low-protein-diet-influence-the-uremic-toxin-serum-levels-from-the-gut-microbiota-in-nondialysis-chronic-kidney-disease-patients
#8
Ana Paula Black, Juliana S Anjos, Ludmila Cardozo, Flávia L Carmo, Carla J Dolenga, Lia S Nakao, Dennis de Carvalho Ferreira, Alexandre Rosado, José Carlos Carraro Eduardo, Denise Mafra
OBJECTIVES: To evaluate the effects of low-protein diet (LPD) on uremic toxins and the gut microbiota profile in nondialysis chronic kidney disease (CKD) patients. DESIGN AND METHODS: Longitudinal study with 30 nondialysis CKD patients (stage 3-4) undergoing LPD for 6 months. Adherence to the diet was evaluated based on the calculation of protein equivalent of nitrogen appearance from the 24-hour urine analysis. Good adherence to LPD was considered when protein intake was from 90% to 110% of the prescribed amount (0...
February 10, 2018: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29439004/assessing-the-nutrient-intake-of-a-low-carbohydrate-high-fat-lchf-diet-a-hypothetical-case-study-design
#9
Caryn Zinn, Amy Rush, Rebecca Johnson
OBJECTIVE: The low-carbohydrate, high-fat (LCHF) diet is becoming increasingly employed in clinical dietetic practice as a means to manage many health-related conditions. Yet, it continues to remain contentious in nutrition circles due to a belief that the diet is devoid of nutrients and concern around its saturated fat content. This work aimed to assess the micronutrient intake of the LCHF diet under two conditions of saturated fat thresholds. DESIGN: In this descriptive study, two LCHF meal plans were designed for two hypothetical cases representing the average Australian male and female weight-stable adult...
February 8, 2018: BMJ Open
https://www.readbyqxmd.com/read/29438776/quercetin-ameliorates-hfd-induced-nafld-by-promoting-hepatic-vldl-assembly-and-lipophagy-via-the-ire1a-xbp1s-pathway
#10
Xinhong Zhu, Ting Xiong, Peiyi Liu, Xiaoping Guo, Lin Xiao, Feng Zhou, Yuhan Tang, Ping Yao
The consumption of a quercetin-rich diet has been well-established as a feasible method against non-alcoholic fatty liver disease (NAFLD); however, the molecular mechanisms underlying the progression of NAFLD and its intervention by quercetin remain largely obscure. Male Sprague-Dawley rats fed high-fat diet (HFD), and HepG2 cells stimulated with free fatty acid, were treated with quercetin and various pharmacological reagents to explore the effect of signaling pathways involved in endoplasmic reticulum stress on very low-density lipoprotein (VLDL) assembly and lipophagy...
February 10, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29436695/inhibition-of-mammalian-target-of-rapamycin-complex-1-signaling-by-n-3-polyunsaturated-fatty-acids-promotes-locomotor-recovery-after-spinal-cord-injury
#11
Jiping Nie, Jian Chen, Jianguo Yang, Qinqin Pei, Jing Li, Jia Liu, Lixin Xu, Nan Li, Youhao Chen, Xiaohua Chen, Hao Luo, Tiansheng Sun
The present study aimed to explore the effects of n‑3 polyunsaturated fatty acids (PUFAs) on autophagy and their potential for promoting locomotor recovery after spinal cord injury (SCI). Primary neurons were isolated and cultured. Sprague‑Dawley rats were randomly divided into three groups and fed diets with different amounts of n‑3 PUFAs. A model of spinal cord contusion was created at the T10 spinal segment and the composition of PUFAs was analyzed using gas chromatography. Spinal repair and motor function were evaluated postoperatively...
February 8, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29434819/tangshen-formula-improves-inflammation-in-renal-tissue-of-diabetic-nephropathy-through-sirt1-nf-%C3%AE%C2%BAb-pathway
#12
Yue-Guang Du, Ke-Na Zhang, Zong-Lei Gao, Fengjiao Dai, Xi-Xi Wu, Ke-Fu Chai
The present study investigated the mechanism underlying the anti-inflammatory effects of Tangshen formula (TS) in Sprague Dawley (SD) rats with diabetic nephropathy (DN). A rat model of DN was established by intraperitoneal injection of 1% (40 mg/kg) streptozotocin and administration of a high fat and glucose diet. Subsequently, SD rats were randomly divided into six groups (n=8): A DN group, a valsartan group, a high-dose TS group, a middle-dose TS group, a low-dose TS group and a control group with normal SD rats...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29434785/nephroprotective-effects-of-diacylglycerol-on-diabetic-nephropathy-in-type-2-diabetic-rats
#13
Jianpeng Li, Yongheng Yan, Duo Li, Xia Li, Xinying Lin, Zhenhua Liu, Tongcheng Xu, Fangling Du
Diacylglycerol (DAG) has been reported to reduce the serum lipid and glucose levels more effectively compared with triacylglycerol (TAG). The present study examined the long-term effects of dietary DAG on rats with type 2 diabetic nephropathy (DN). The type 2 DN model was established by administering a high-fat and high-calorie diet along with an intraperitoneal injection of 35 mg/kg body weight streptozocin, and the disease developed over the following 8 weeks. Sprague-Dawley rats were then randomly divided into the control, TAG, low-dose DAG (Low-DAG) and high-dose DAG (High-DAG) groups...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29434537/how-can-a-ketogenic-diet-improve-motor-function
#14
REVIEW
Charlotte Veyrat-Durebex, Pascal Reynier, Vincent Procaccio, Rudolf Hergesheimer, Philippe Corcia, Christian R Andres, Hélène Blasco
A ketogenic diet (KD) is a normocaloric diet composed by high fat (80-90%), low carbohydrate, and low protein consumption that induces fasting-like effects. KD increases ketone body (KBs) production and its concentration in the blood, providing the brain an alternative energy supply that enhances oxidative mitochondrial metabolism. In addition to its profound impact on neuro-metabolism and bioenergetics, the neuroprotective effect of specific polyunsaturated fatty acids and KBs involves pleiotropic mechanisms, such as the modulation of neuronal membrane excitability, inflammation, or reactive oxygen species production...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29434318/exploring-the-association-between-serum-25-hydroxyvitamin-d-and-serum-lipids-more-than-confounding
#15
Rolf Jorde, Guri Grimnes
BACKGROUND/OBJECTIVES: In observational, but not interventional, studies there are strong associations between serum 25-hydroxyvitamin D (25(OH)D) and serum lipids. The purpose of the present study was to examine potential causes of this association. SUBJECTS/METHODS: A total of 17,411 subjects participating in the seventh survey of the Tromsø Study were included in the cross-sectional study; 5384 subjects who participated in both the sixth and seventh survey were included in the longitudinal study; 2365 subjects who participated in both the fourth and seventh survey were included in the genetic study; and 479 subjects with impaired glucose tolerance were included in the vitamin D binding protein (DBP) analyses...
February 12, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29434315/association-of-gut-microbial-communities-with-plasma-lipopolysaccharide-binding-protein-lbp-in-premenopausal-women
#16
Jessica S Citronberg, Keith R Curtis, Emily White, Polly A Newcomb, Katherine Newton, Charlotte Atkinson, Xiaoling Song, Johanna W Lampe, Meredith Aj Hullar
The mechanisms by which obesity increases cancer risk are unclear, but some lines of evidence suggest that gut microbial communities (GMC) may contribute to chronic inflammation in obese individuals through raised systemic levels of lipopolysaccharides (LPS). We evaluated associations of the GMC in stool with plasma LPS-binding protein (LBP, a measure of LPS) and C-reactive protein (CRP) concentrations in 110 premenopausal women in the United States. Diet was assessed using 3-day food records and GMCs were evaluated using pyrosequencing of the 16S rRNA gene...
February 12, 2018: ISME Journal
https://www.readbyqxmd.com/read/29434287/angiotensin-ii-type-1-receptor-associated-protein-inhibits-angiotensin-ii-induced-insulin-resistance-with-suppression-of-oxidative-stress-in-skeletal-muscle-tissue
#17
Kohji Ohki, Hiromichi Wakui, Nozomu Kishio, Kengo Azushima, Kazushi Uneda, Sona Haku, Ryu Kobayashi, Kotaro Haruhara, Sho Kinguchi, Takahiro Yamaji, Takayuki Yamada, Shintaro Minegishi, Tomoaki Ishigami, Yoshiyuki Toya, Akio Yamashita, Kento Imajo, Atsushi Nakajima, Ikuma Kato, Kenichi Ohashi, Kouichi Tamura
Enhancement of AT1 receptor-associated protein (ATRAP) in adipose tissue improves high fat diet (HFD)-induced visceral obesity and insulin resistance, and suppresses adipose oxidative stress. However, HFD loading is not a direct stimulatory factor for AT1 receptor. In the present study, we investigated the effect of chronic, low-dose angiotensin II (Ang II) stimulation on glucose and lipid metabolism in mice and functional role of ATRAP. ATRAP expression was higher in adipose tissue (5-10-fold) and skeletal muscle tissue (approximately 1...
February 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29434077/low-proportion-of-dietary-plant-protein-among-athletes-with-premenstrual-syndrome-related-performance-impairment
#18
Keiko Yamada, Takashi Takeda
Premenstrual syndrome (PMS) is psychosomatic disorder that are limited to the late luteal phase in the menstrual cycle. PMS could impair athletic performance. To investigate associations between proportions of dietary plant and animal protein and PMS-related impairment of athletic performance, we surveyed 135 female athletes aged 18-23 years attending Kindai University. Participants belonged to authorized university clubs, all of which have high rankings in Japanese university sports. Participants completed self-administered questionnaires on diet history, demographics, and PMS-related impairment of athletic performance...
2018: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29433755/vitamin-mineral-and-micronutrient-status-in-patients-with-classical-phenylketonuria
#19
Engin Kose, Nur Arslan
BACKGROUND & AIMS: Strict low-phenylalanine diet is associated with an increased risk of developing micronutrient deficiencies in patients with phenylketonuria (PKU). The primary objective of this single-center, case-control study was to assess the nutritional parameters of patients with PKU on strict low-phenylalanine diet without vitamin and mineral supplementation compared to a healthy control group. Secondary objective was to identify the adequacy of vitamin/mineral supplementation in phenylalanine-free (Phe-free) amino acid formulas...
February 9, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29433333/growth-performance-duodenal-morphology-and-the-caecal-microbial-population-in-female-broiler-chickens-fed-glycine-fortified-low-protein-diets-under-heat-stress-conditions
#20
Elmutaz Awad, Zulkifli Idrus, Abdoreza Soleimani Farjam, Alhassan O Bello, M Faseleh-Jahromi
1. This study was undertaken to examine the effect of feeding glycine (Gly)-fortified low protein diets on the growth performance, duodenal morphology and caecal microbial populations of broiler chickens raised under unheated, cyclic or constant heat stress environmental conditions. 2. From d 1 - 21 (starter phase), an equivalent number of birds were fed either a normal protein (NP) diet or a low protein (LP) diet fortified with Gly. From d 22 - 42 (grower phase), an equivalent number of birds from each starter diet were distributed to one of the following dietary groups: (1) a normal protein diet during the starter and grower phases (NPNP), (2) a normal protein diet during the starter phase and a low protein diet during the grower phase (NPLP), (3) a low protein diet during the starter phase and a normal protein diet during the grower phase (LPNP) or (4) low protein diets during both phases (LPLP)...
February 13, 2018: British Poultry Science
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