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https://www.readbyqxmd.com/read/29910739/effects-of-dietary-phosphorus-level-on-the-expression-of-calcium-and-phosphorus-transporters-in-laying-hens
#1
Peng Li, Rongmei Wang, Hongchao Jiao, Xiaojuan Wang, Jingpeng Zhao, Hai Lin
The transport of calcium and phosphorus is mainly relied on their corresponding transporters. The aim of this study was to determine the effect of dietary phosphorus level on the expression of the relevant calcium and phosphorus transporters in laying hens, which has a large amount of calcium and phosphorus input from intestine and output from kidney and eggshell gland. Thirty-six 25-week-old Hy-line Brown hens were fed diets with different available phosphorus level (AP, 0.15, 0.41, and 0.82%), respectively...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29908322/chitooligosaccharide-supplementation-in-low-fish-meal-diets-for-pacific-white-shrimp-litopenaeus-vannamei-effects-on-growth-innate-immunity-gut-histology-and-immune-related-genes-expression
#2
Samad Rahimnejad, Xiangli Yuan, Ling Wang, Kangle Lu, Kai Song, Chunxiao Zhang
This study evaluated the effects of supplementing chitooligosaccharide (COS) in low fish meal (FM) diets on growth, immune response, intestine and hepatopancrease histology, and expression of inflammatory and immune-related genes in Pacific white shrimp (Litopenaeus vannamei). A basal diet was formulated using FM and soybean meal (SM) as primary protein sources and considered as a high FM (HFM) diet, then a low FM (LFM) diet was prepared by substituting 50% of FM with SM and supplemented with 0, 3, 6, 9, 12 or 15 g COS kg-1 diet (LFM, COS3, COS6, COS9, COS12 and COS15 diets)...
June 13, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29907443/apoa-1milano-muteins-orally-delivered-via-genetically-modified-rice-show-anti-atherogenic-and-anti-inflammatory-properties-in-vitro-and-in-apoe-atherosclerotic-mice
#3
Gabriele Romano, Serena Reggi, Barbara Kutryb-Zajac, Amanda Facoetti, Elisa Chisci, Mariateresa Pettinato, Maria Rita Giuffrè, Federica Vecchio, Silvia Leoni, Marco De Giorgi, Federica Avezza, Massimiliano Cadamuro, Luca Crippa, Biagio Eugenio Leone, Marialuisa Lavitrano, Ilaria Rivolta, Donatella Barisani, Ryszard Tomasz Smolenski, Roberto Giovannoni
BACKGROUND: Atherosclerosis is a slowly progressing, chronic multifactorial disease characterized by the accumulation of lipids, inflammatory cells, and fibrous tissue that drives to the formation of asymmetric focal thickenings in the tunica intima of large and mid-sized arteries. Despite the high therapeutic potential of ApoA-1 proteins, the purification and delivery into the disordered organisms of these drugs is still limited by low efficiency in these processes. METHODS AND RESULTS: We report here a novel production and delivery system of anti-atherogenic APOA-1Milano muteins (APOA-1M) by means of genetically modified rice plants...
June 11, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29907153/comparison-of-two-low-fat-diets-differing-in-protein-and-carbohydrate-on-psychological-wellbeing-in-adults-with-obesity-and-type-2-diabetes-a-randomised-clinical-trial
#4
Nerylee Ann Watson, Kathryn Ann Dyer, Jonathan David Buckley, Grant David Brinkworth, Alison Mary Coates, Gaynor Parfitt, Peter Ranald Charles Howe, Manny Noakes, Karen Joy Murphy
BACKGROUND: Although higher-protein diets (HP) can assist with weight loss and glycemic control, their effect on psychological wellbeing has not been established. The objective of this study was to compare the effects of a HP and a higher-carbohydrate diet (HC), combined with regular exercise, on psychological wellbeing both during weight loss (WL) and weight maintenance phases (WM). METHODS: In a parallel RCT, 61 adults with T2D (mean ± SD: BMI 34.3 ± 5...
June 15, 2018: Nutrition Journal
https://www.readbyqxmd.com/read/29904374/alpha-ketoglutarate-in-low-protein-diets-for-growing-pigs-effects-on-cecal-microbial-communities-and-parameters-of-microbial-metabolism
#5
Jiashun Chen, Baoju Kang, Qian Jiang, Mengmeng Han, Yurong Zhao, Lina Long, Chenxing Fu, Kang Yao
Alpha-ketoglutarate (AKG), a critical molecule in the tricarboxylic acid cycle, is beneficial to intestinal functions. However, its influence on intestinal microbiota and metabolism is not fully understood. We investigated the effects of a low-protein (LP) diet supplemented with AKG on cecal microbial communities and the parameters of microbial metabolism in growing pigs. Twenty-seven young pigs (Large White × Landrace) with an average initial body weight of 11.96 ± 0.18 kg were randomly allotted into three groups ( n = 9): a normal protein (NP) diet containing 20% crude protein (CP); LP diet formulated with 17% CP (LP diet); or LP diet supplemented with 10 g kg-1 of AKG (ALP diet)...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29903846/dietary-patterns-over-time-and-microalbuminuria-in-youth-and-young-adults-with-type-1-diabetes-the-search-nutrition-ancillary-study
#6
Tina Costacou, Jamie Crandell, Anna R Kahkoska, Angela D Liese, Dana Dabelea, Jean M Lawrence, David J Pettitt, Kristi Reynolds, Elizabeth J Mayer-Davis, Amy K Mottl
OBJECTIVE: We assessed the association between diet quality and microalbuminuria in youth-onset type 1 diabetes using three indices: a modified Mediterranean diet score for children and adolescents (mKIDMED), the Dietary Approaches to Stop Hypertension (DASH), and the Healthy Eating Index-2010 (HEI). RESEARCH DESIGN AND METHODS: Youth and young adults from the SEARCH (Search for Diabetes in Youth) Nutrition Ancillary Study diagnosed with type 1 diabetes in 2002-2008, who had repeated dietary assessments at baseline and follow-up visits and urine albumin-to-creatinine ratio (UACR) measured at the outcome visit (2012-2015) ( n = 461), were selected for study...
June 14, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29903737/inactivation-of-the-e3-ubiquitin-ligase-idol-inducible-degrader-of-the-low-density-lipoprotein-receptor-attenuates-diet-induced-obesity-and-metabolic-dysfunction-in-mice
#7
Nienke M van Loon, Roelof Ottenhoff, Sander Kooijman, Martina Moeton, Saskia Scheij, Reinout L P Roscam Abbing, Marion J J Gijbels, Johannes H M Levels, Vincenzo Sorrentino, Jimmy F P Berbée, Patrick C N Rensen, Noam Zelcer
OBJECTIVE: The E3 ubiquitin ligase IDOL (inducible degrader of the LDLR [LDL (low-density lipoprotein) receptor]) is a post-transcriptional regulator of LDLR abundance. Model systems and human genetics support a role for IDOL in regulating circulating LDL levels. Whether IDOL plays a broader metabolic role and affects development of metabolic syndrome-associated comorbidities is unknown. APPROACH AND RESULTS: We studied WT (wild type) and Idol ( -/ - ) (Idol-KO) mice in 2 models: physiological aging and diet-induced obesity...
June 14, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29903237/-effects-of-medium-chain-fatty-acids-on-high-density-lipoprotein-in-rats-fed-with-high-fat-diet
#8
Yong Zhang, Xueyan Yang, Xinsheng Zhang, Qing Xu, Xiaoming Yu, Changyong Xue, Yinghua Liu
OBJECTIVE: To explore the effects of medium-chain fatty acid( MCFA) on high-density-lipoprotein( HDL) in serum, liver and small intestine in Sprague Dawley rats fed with high fat diet. METHODS: Thirty obese rats were divided into 3 groups randomly, and were fed high fat diet mixed with 2% octanoic acid, 2% decanoic acid, 2% oleic acid respectively for 8 weeks. The levels of blood HDL, apolipoprotein A1( ApoA1), apolipoprotein A2( ApoA2), triglyceride( TG), total cholesterol( TC), high-densitylipoprotein cholesterol( HDL-c), low-density lipoprotein cholesterol( HDL-c) in serum were measured at the fourth and eighth week...
January 2018: Wei Sheng Yan Jiu, Journal of Hygiene Research
https://www.readbyqxmd.com/read/29903176/-follow-up-study-on-diet-folic-acid-and-iron-status-in-358-cases-of-uighur-pregnant-women-from-xinjiang-kashi
#9
Tuerxunjiang Maimaitiming, Xiaojun Wang, Camila Tuerxunjiang, Yanqiong Yang, Dilihuomaer Wuerkaixi, Jinfen Pu, Li Wang, Liuqianzi Yan
OBJECTIVE: To understand the dietary intake situation of Uighur pregnant women, investigate folic acid level and its influencing factors, to provide evidence for health education of maternal nutrition and implementation of proper nutrition, balanceddiet guidance. METHODS: 358 cases of Uighur trimester pregnant women for the study, took the method of 3 d 24 h dietary recall to survey their dietary and collect blood samples. The Hb was detected by the cyanide methemoglobinmethod...
July 2017: Wei Sheng Yan Jiu, Journal of Hygiene Research
https://www.readbyqxmd.com/read/29902229/mir-146a-deficiency-in-hematopoietic-cells-is-not-involved-in-the-development-of-atherosclerosis
#10
Alberto Del Monte, Ana B Arroyo, María J Andrés-Manzano, Nuria García-Barberá, María S Caleprico, Vicente Vicente, Vanessa Roldán, Rocío González-Conejero, Constantino Martínez, Vicente Andrés
BACKGROUND: Atherosclerosis involves activation of the IRAK1/TRAF6/NF-κB inflammatory cascade, which is negatively regulated by miR146a. Previous studies showed that the TT genotype of rs2431697, located near the miR-146a gene, drives lower miR-146a transcription and predicts adverse cardiovascular events in anticoagulated atrial fibrillation patients. Moreover, systemic miR-146a administration protects mice from atherosclerosis. Here we evaluated the ability of miR-146a expression in the hematopoietic component to regulate atherosclerosis in low-density lipoprotein receptor-null mice (Ldlr-/-)...
2018: PloS One
https://www.readbyqxmd.com/read/29901732/growth-and-clinical-variables-in-nitrogen-restricted-piglets-fed-an-adjusted-essential-amino-acid-mix-effects-of-free-amino-acid-based-diets
#11
Mikkel Lykke, Per T Sangild, Johannes B van Goudoever, Dewi van Harskamp, Henk Schierbeek, Berthold Koletzko, Eline M van der Beek, Marieke Abrahamse-Berkeveld, Bert J M van de Heijning, Barbara Stoll, Douglas G Burrin, Thomas Thymann
Background: Excess protein intake in early life has been linked to obesity and metabolic syndrome in later life. Yet protein, and in particular the essential amino acids (EAAs), need to be present in adequate quantity to support growth. Objective: With the use of a piglet model restricted in dietary amino acids (AAs), we compared the efficacy and safety of a standard formula with a low-AA formula containing an adjusted AA composition. Methods: Female piglets (3-7 d old; Landrace × Yorkshire × Duroc) were fed 1 of 4 isoenergetic AA-based formulas for 14 d (700 kJ · kg body weight-1 · d-1)...
May 13, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29900811/anxiety-like-behavior-and-structural-changes-of-the-bed-nucleus-of-the-stria-terminalis-bnst-in-gestational-protein-restricted-male-offspring
#12
D B Torres, A Lopes, A J Rodrigues, J J Cerqueira, N Sousa, J A R Gontijo, P A Boer
Animal evidence has suggested that maternal emotional and nutritional stress during pregnancy is associated with behavioral outcomes in offspring. The nature of the stresses applied may differ, but it is often assumed that the mother's hippocampus-hypothalamic-pituitary-adrenal (HHPA) axis response releases higher levels of glucocorticoid hormones. The bed nucleus of the stria terminalis (BNST) is in a pivotal position to regulate the HHPA axis and the stress response, and it has been implicated in anxiety behavior...
June 14, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29900568/parental-diet-affects-embryogenesis-of-the-great-pond-snail-lymnaea-stagnalis-exposed-to-cadmium-pyraclostrobin-and-tributyltin
#13
Evelyn G Reátegui-Zirena, Christopher J Salice
Diet quality has a strong impact on life history traits but it is not usually considered as a factor in toxicity tests. The purpose of this study was to evaluate how diets differing in nutritional content affect sensitivity to cadmium, pyraclostrobin and tributyltin in Lymnaea stagnalis offspring. Three groups were fed a different diet each; lettuce, high-caloric pellets, or a combination of both. Snails fed pellets and both diets had similar growth; however, snails fed lettuce showed lower growth until the 4th month...
June 13, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29899183/dietary-intake-during-56-weeks-of-a-low-fat-diet-for-lomitapide-treatment-in-japanese-patients-with-homozygous-familial-hypercholesterolemia
#14
Noriko Kameyama, Chizuko Maruyama, Fuyuha Kitagawa, Kazunobu Nishii, Kaori Uenomachi, Yayoi Katayama, Hiromi Koga, Naoko Chikamoto, Yuko Kuwata, Junko Torigoe, Masako Arimoto, Toshiaki Tokumaru, Katsunori Ikewaki, Atsushi Nohara, Yoshihiko Otsubo, Koji Yanagi, Masayuki Yoshida, Mariko Harada-Shiba
AIM: Lomitapide is an oral inhibitor of the microsomal triglyceride transfer protein used to treat homozygous familial hypercholesterolemia (HoFH); patients require a low-fat diet to minimize gastrointestinal adverse effects and dietary supplements to prevent nutrient deficiencies. We investigated the diet and nutritional status during lomitapide treatment. METHODS: Japanese patients with HoFH, who were in a phase 3 trial of lomitapide, were instructed to start low-fat diets with supplements of vitamin E and essential fatty acids 6 weeks before starting lomitapide treatment...
June 12, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29897547/dietary-supplemented-effects-of-mannan-oligosaccharides-on-biochemical-parameters-of-4-close-bred-flocks-of-japanese-quail-breeders
#15
M A Iqbal, N Roohi, O Khan
The current study was carried out to investigate the consequences of mannan-oligosaccharides (MOS), a prebiotic, as feed supplement on biochemical parameters of Japanese quail breeders (Coturnix coturnix japonica). Twelve-week-old, 960 birds, belonging to 4 close-bred flocks (CBF), were randomly selected and divided into 4 treatment groups with 3 replicates according to pattern (4 strains × 4 treatment groups × 3 replicates). Birds were fed corn-based basal diet or the same diet supplemented with 0.25, 0...
June 8, 2018: Poultry Science
https://www.readbyqxmd.com/read/29897085/the-anti-obesity-effect-of-starch-in-a-whole-grain-like-structural-form
#16
Kaiyun Luo, Xufeng Wang, Genyi Zhang
Obesity is a risk factor for many chronic diseases, and the anti-obesity effect of starch in a whole grain-like structural form (WGLSF) prepared through co-gelation with oat β-glucan and alginate was studied using high-fat (HF) induced obese male C57BL/6J mice. In vitro human fecal fermentation of WGLSF-starch showed a slower rate of fermentation and a higher production of butyric acid (132.0 μmol per 50 mg sample) when compared to the physical mixture counterpart of starch, β-glucan, and alginate (PM) (110...
June 13, 2018: Food & Function
https://www.readbyqxmd.com/read/29895529/pcsk9-in-cholesterol-metabolism-from-bench-to-bedside
#17
REVIEW
Allison B Reiss, Neal Shah, Dalia Muhieddine, Juan Zhen, Jennifer Yudkevich, Lora J Kasselman, Joshua DeLeon
Dyslipidemia, and specifically elevated low-density lipoprotein (LDL) cholesterol, is one of the most important cardiovascular risk factors. Statins are considered first line therapy for the primary and secondary prevention of cardiovascular disease. However, statins may not be adequate treatment for elevated circulating LDL levels and are ineffective in certain familial hypercholesterolemias. The discovery of proprotein convertase subtilisin/kexin type 9 (PCSK9), a regulatory protein that affects LDL receptors, offers a new alternative for these patients...
June 15, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29895294/comparing-the-inflammatory-profiles-for-incidence-of-diabetes-mellitus-and-cardiovascular-diseases-a-prospective-study-exploring-the-common-soil-hypothesis
#18
Xue Bao, Yan Borné, Linda Johnson, Iram Faqir Muhammad, Margaretha Persson, Kaijun Niu, Gunnar Engström
BACKGROUND: Chronic low-grade inflammation and associated insulin resistance and metabolic abnormalities have been proposed as 'common soil' for diabetes mellitus (DM) and cardiovascular disease (CVD). This paper aimed to investigate the inflammatory profiles of DM and CVD and to distinguish their shared and specific markers. METHODS: Based on the Malmö Diet and Cancer cohort, total and differential leukocyte counts were measured in 25,969 participants without previous DM or CVD and were studied in relation to incident DM (mean follow-up 17...
June 12, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29895283/il-10-stat3-is-reduced-in-childhood-obesity-with-hypertriglyceridemia-and-is-related-to-triglyceride-level-in-diet-induced-obese-rats
#19
Yuesheng Liu, Dong Xu, Chunyan Yin, Sisi Wang, Min Wang, Yanfeng Xiao
BACKGROUND: The prevalence of childhood obesity and obesity-related metabolic disorder such as dyslipidemia has sharply increased in the past few decades. Chronic low-grade inflammation is associated with the development of comorbidities and poor prognosis in obesity. This study aims to evaluate interleukin-10 (IL-10) in childhood obesity with hypertriglyceridemia. METHOD: We evaluated IL-10 and signal transducer and activator of transcription 3 (STAT3) mRNA expression in adipose tissue (AT) as well as serum IL-10 in 62 children of 3 groups and in high-fat diet (HFD) induced obese rat...
June 13, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29888581/-acupuncture-treatment-of-polycystic-ovarian-syndrome-patients-with-abdominal-obesity-by-regulating-dai-meridian-a-randomized-controlled-clinical-trial
#20
Ling-Yu Shen, Cui-Mei Liang, Wen-Jin Yang, Liang Pan, Hua Li, Hui Hu
OBJECTIVE: To explore the therapeutic effect of acupuncture in the treatment of polycystic ovarian syndrome (PCOS) patients with abdominal obesity by regulating glucose metabolism, insulin resistance, sex hormones, etc. METHODS: Eligible PCOS volunteers were randomly divided into treatment group( n =30) and control group( n =28). The treatment group received acupuncture therapy three times a week combined with diet control and exercise. EA (2 Hz/100 Hz, 4-8 mA) was applied to bilateral Daimai (GB 26)and Tianshu (ST 25) for 20 min/time, and bilateral Daheng (SP 15), Shenshu (BL 23), Ciliao (BL 32), Guilai (ST 29), Zulinqi (GB 41) and Waiguan (SJ 5) were stimulated with filiform needles, with the needles retained for 20 min...
April 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
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