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https://www.readbyqxmd.com/read/28807887/an-integrative-system-biology-approach-to-unravel-potential-drug-candidates-for-multiple-age-related-disorders
#1
Isha Srivastava, Pooja Khurana, Mohini Yadav, Yasha Hasija
Aging, though an inevitable part of life, is becoming a worldwide social and economic problem. Healthy aging is usually marked by low probability of age related disorders. Good therapeutic approaches are still in need to cure age related disorders. Occurrence of more than one ARD in an individual, expresses the need of discovery of such target proteins, which can affect multiple ARDs. Advanced scientific and medical research technologies throughout last three decades have arrived to the point where lots of key molecular determinants affect human disorders can be examined thoroughly...
August 11, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28799850/a-qualitative-study-exploring-factors-associated-with-pap-test-use-among-north-korean-refugees
#2
Kyounghae Kim, Soohyun Kim, Yoonkyung Chung
Lack of medical care in North Korea and vulnerability to human trafficking during their migration increase risks of cervical cancer among North Korean refugees. To better understand factors influencing Pap test use, we conducted a qualitative study of 8 North Korean refugees in South Korea. Individual barriers were limited knowledge, lack of perceived need for preventive services, and concerns about costs. Environmental facilitators included having female providers, receiving family support, and free screenings...
August 11, 2017: Health Care for Women International
https://www.readbyqxmd.com/read/28798503/working-up-a-good-sweat-the-challenges-of-standardising-sweat-collection-for-metabolomics-analysis
#3
REVIEW
Joy N Hussain, Nitin Mantri, Marc M Cohen
INTRODUCTION: Human sweat is a complex biofluid of interest to diverse scientific fields. Metabolomics analysis of sweat promises to improve screening, diagnosis and self-monitoring of numerous conditions through new applications and greater personalisation of medical interventions. Before these applications can be fully developed, existing methods for the collection, handling, processing and storage of human sweat need to be revised. This review presents a cross-disciplinary overview of the origins, composition, physical characteristics and functional roles of human sweat, and explores the factors involved in standardising sweat collection for metabolomics analysis...
February 2017: Clinical Biochemist. Reviews
https://www.readbyqxmd.com/read/28795618/distribution-of-dental-plaque-and-gingivitis-within-the-dental-arches
#4
Prem K Sreenivasan, Kakarla V V Prasad
Objective The natural accumulation of supragingival plaque on surfaces of human teeth is associated with gingival inflammation and the initiation of common oral diseases. This study evaluated the distribution of dental plaque and gingivitis scores within the dental arches after prophylaxis. Methods Adult subjects from the Dharwad, India area representing the general population who provided written informed consent were scheduled for screening. Healthy subjects over the age of 18 years, not currently requiring any medical or dental care, and presenting with a complement of at least 20 natural teeth were recruited for this parallel design study...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28795359/the-diagnostics-of-human-steroid-hormone-disorders
#5
Małgorzata Dobosz, Aneta Manda-Handzlik, Beata Pyrżak, Urszula Demkow
Disturbances of the steroidogenesis or altered peripheral metabolism of steroids may result in severe clinical manifestations. Therefore, prompt diagnosis and initiation of medical treatment are desirable. The diagnostics of disorders of steroid hormone production, metabolism, and action have been previously based on immunoassay tests. However, in a modern medical laboratory, due to low accuracy of immunoassays, this technique is continuously replaced by chromatographic separation methods coupled to mass spectrometric detection systems...
August 10, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28795223/high-resolution-melting-pcr-assay-applicable-for-diagnostics-and-screening-studies-allowing-detection-and-differentiation-of-several-babesia-spp-infecting-humans-and-animals
#6
Wioletta Rozej-Bielicka, Aleksander Masny, Elzbieta Golab
The goal of the study was to design a single tube PCR test for detection and differentiation of Babesia species in DNA samples obtained from diverse biological materials. A multiplex, single tube PCR test was designed for amplification of approximately 400 bp region of the Babesia 18S rRNA gene. Universal primers were designed to match DNA of multiple Babesia spp. and to have low levels of similarity to DNA sequences of other intracellular protozoa and Babesia hosts. The PCR products amplified from Babesia DNA isolated from human, dog, rodent, deer, and tick samples were subjected to high-resolution melting analysis for Babesia species identification...
August 10, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28782502/society-for-maternal-fetal-medicine-smfm-consult-series-43-hepatitis-c-in-pregnancy-screening-treatment-and-management
#7
Brenna L Hughes, Charlotte M Page, Jeffrey A Kuller
In the United States, 1-2.5% of pregnant women are infected with hepatitis C virus (HCV), which carries an approximately 5% risk of transmission from mother to infant. HCV can be transmitted to the infant in utero or during the peripartum period, and infection during pregnancy is associated with increased risk of adverse fetal outcomes, including fetal growth restriction and low birth weight. The purpose of this document is to discuss the current evidence regarding HCV in pregnancy and to provide recommendations on screening, treatment, and management of this disease during pregnancy...
August 3, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28776339/trends-in-malignancies-among-korean-patients-infected-with-human-immunodeficiency-virus-in-the-highly-active-antiretroviral-therapy-era
#8
Shinwon Lee, Sun Hee Lee, Jeong Eun Lee, Jin Suk Kang, Seung Geun Lee, Joo Seop Chung, Ihm Soo Kwak
Since the introduction of highly active antiretroviral therapy, the life span of people with human immunodeficiency virus (HIV) or AIDS (PWHA) has been extended significantly. Therefore, the importance of non-AIDS-defining cancers (NADCs), as well as AIDS-defining cancers (ADCs) has increased. There is little information concerning the epidemiology of malignancies in PWHA in Korea. A descriptive epidemiologic study was conducted at a tertiary care hospital in Korea. PWHA who visited Pusan National University Hospital from January 2000 to October 2014 were included...
September 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28774274/epidemiology-of-humanpapilloma-virus-infection-among-women-in-fujian-china
#9
Conglian Wu, Xianjin Zhu, Yanli Kang, Yinping Cao, Pingxia Lu, Wenjuan Zhou, Hong Zhou, Yang Zhang, Yanfang Song
BACKGROUND: Human papillomavirus (HPV) infection is the main etiological factor for the development of cervical cancer. Here we assessed the prevalence and distribution of HPV genotypes in Fujian population. METHODS: A total of 8678 women aging from 17 to 84 years olds were recruited from the Fujian Medical University Union Hospital in Fujian Province. Every woman had a face-to-face interview. Cervical samples were collected from each participant and HPV screening was conducted using microarray hybridization...
August 3, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28765470/the-role-of-oral-health-care-professionals-in-providing-medical-services
#10
Michael Glick, Barbara L Greenberg
Integration of oral health care professionals (OHCPs) into medical care could advance efforts to control increasingly prevalent conditions such as cardiovascular disease, diabetes mellitus, human immunodeficiency virus infection, and hepatitis C infection, each of which is associated with significant morbidity and health care costs. Prevention and early intervention are effective for reducing the incidence and severity of these diseases, while increasing cost of health care may drive the need for nontraditional models of health education and delivery...
August 2017: Journal of Dental Education
https://www.readbyqxmd.com/read/28760744/proanthocyanidin-trimer-gallate-modulates-lipid-deposition-and-fatty-acid-desaturation-in-caenorhabditis-elegans
#11
Yu Nie, Brad Littleton, Thomas Kavanagh, Vincenzo Abbate, Sukhvinder S Bansal, David Richards, Peter Hylands, Stephen R Stürzenbaum
The incidence of obesity is rising at an alarming rate. Despite its recognition as an urgent healthcare concern, obesity remains largely an unsolved medical problem. A comprehensive screen for functional dietary phytochemicals identified proanthocyanidins as putative targets to ameliorate obesity. A full-scale purification of oligomeric proanthocyanidins (OPCs) derived from grape seed extract, yielded pure OPC dimer, trimer, tetramer, and their gallates (pOPCs). Forward chemical screening conducted in Caenorhabditis elegans suggested that pOPCs reduced the activity of lipase in vitro and triglyceride storage capacity in vivo Proanthocyanidin trimer gallate in particular modified lipid desaturation in C...
July 31, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28758162/individual-level-factors-associated-with-the-risk-of-acquiring-human-plasmodium-knowlesi-malaria-in-malaysia-a-case-control-study
#12
Matthew J Grigg, Jonathan Cox, Timothy William, Jenarun Jelip, Kimberly M Fornace, Patrick M Brock, Lorenz von Seidlein, Bridget E Barber, Nicholas M Anstey, Tsin W Yeo, Christopher J Drakeley
BACKGROUND: The emergence of human malaria due to the monkey parasite Plasmodium knowlesi threatens elimination efforts in southeast Asia. Changes in land use are thought to be driving the rise in reported P knowlesi cases, but the role of individual-level factors is unclear. To address this knowledge gap we assessed human and environmental factors associated with zoonotic knowlesi malaria risk. METHODS: We did this population-based case-control study over a 2 year period in the state of Sabah in Malaysia...
June 9, 2017: The Lancet. Planetary health
https://www.readbyqxmd.com/read/28751302/smartphone-based-endoscope-system-for-advanced-point-of-care-diagnostics-feasibility-study
#13
Jung Kweon Bae, Andrey Vavilin, Joon S You, Hyeongeun Kim, Seon Young Ryu, Jeong Hun Jang, Woonggyu Jung
BACKGROUND: Endoscopic technique is often applied for the diagnosis of diseases affecting internal organs and image-guidance of surgical procedures. Although the endoscope has become an indispensable tool in the clinic, its utility has been limited to medical offices or operating rooms because of the large size of its ancillary devices. In addition, the basic design and imaging capability of the system have remained relatively unchanged for decades. OBJECTIVE: The objective of this study was to develop a smartphone-based endoscope system capable of advanced endoscopic functionalities in a compact size and at an affordable cost and to demonstrate its feasibility of point-of-care through human subject imaging...
July 27, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28750865/human-head-lice-and-pubic-lice-reveal-the-presence-of-several-acinetobacter-species-in-algiers-algeria
#14
Nassima Mana, Meriem Louni, Philippe Parola, Idir Bitam
There are two majorspecies of medically important lice that parasitize humans: Phthirus pubis, found in pubic hair, and Pediculus humanus. Pediculus humanus consists of two eco types that live in specific niches on the human host: body lice (Pediculus humanus humanus), found on the human body and clothing, and head lice (Pediculus humanus capitis), found on the scalp. To date, only body lice are known to be vectors of human disease; however, it has recently been reported that the DNA of several bacterial agents has been detected in head lice, raising questions about their role in the transmission of pathogens...
August 2017: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/28750007/adding-tsetse-control-to-medical-activities-contributes-to-decreasing-transmission-of-sleeping-sickness-in-the-mandoul-focus-chad
#15
Mahamat Hissene Mahamat, Mallaye Peka, Jean-Baptiste Rayaisse, Kat S Rock, Mahamat Abdelrahim Toko, Justin Darnas, Guihini Mollo Brahim, Ali Bachar Alkatib, Wilfrid Yoni, Inaki Tirados, Fabrice Courtin, Samuel P C Brand, Cyrus Nersy, Idriss Oumar Alfaroukh, Steve J Torr, Mike J Lehane, Philippe Solano
BACKGROUND: Gambian sleeping sickness or HAT (human African trypanosomiasis) is a neglected tropical disease caused by Trypanosoma brucei gambiense transmitted by riverine species of tsetse. A global programme aims to eliminate the disease as a public health problem by 2020 and stop transmission by 2030. In the South of Chad, the Mandoul area is a persistent focus of Gambian sleeping sickness where around 100 HAT cases were still diagnosed and treated annually until 2013. Pre-2014, control of HAT relied solely on case detection and treatment, which lead to a gradual decrease in the number of cases of HAT due to annual screening of the population...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28749733/cytogenetic-surveillance-of-persons-occupationally-exposed-to-genotoxic-chemicals
#16
Jelena Pajic, Dubravka Jovicic, Aleksandar Ps Milovanovic
Human genotoxic exposures can occur environmentally, occupationally or medicinally. The aim of this study was to assess cytogenetic damage (chromosomal aberrations and micronuclei) in persons exposed to chemical agents in medical, agricultural and industrial occupations. The results showed influences of age, gender, occurrence and duration of exposure on the extent of cytogenetic damage, but no influence of smoking. Persons exposed to pesticides were allocated significantly higher values of most examined parameters...
July 27, 2017: Archives of Environmental & Occupational Health
https://www.readbyqxmd.com/read/28746985/west-nile-virus-lineage-2-in-culex-specimens-from-iran
#17
Nariman Shahhosseini, Sadegh Chinikar, Seyed Hassan Moosa-Kazemi, Mohammad Mehdi Sedaghat, Mohammad Hassan Kayedi, Renke Lühken, Jonas Schmidt-Chanasit
OBJECTIVE: Screening of mosquitoes for viruses is an important forecasting tool for emerging and reemerging arboviruses. Iran has been known to harbor medically important arboviruses such as West Nile virus (WNV) and dengue virus (DENV) based on seroepidemiological data. However, there are no data about the potential mosquito vectors for arboviruses in Iran. This study was performed to provide mosquito and arbovirus data from Iran. MATERIALS AND METHODS: 32,317 mosquitos were collected at 16 sites in 5 provinces of Iran in 2015 and 2016...
July 26, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28744013/the-t-cell-leukemia-associated-ribosomal-rpl10-r98s-mutation-enhances-jak-stat-signaling
#18
T Girardi, S Vereecke, S O Sulima, Y Khan, L Fancello, J W Briggs, C Schwab, J O de Beeck, J Verbeeck, J Royaert, E Geerdens, C Vicente, S Bornschein, C J Harrison, J P Meijerink, J Cools, J D Dinman, K R Kampen, K De Keersmaecker
Several somatic ribosome defects have recently been discovered in cancer, yet their oncogenic mechanisms remain poorly understood. Here we investigated the pathogenic role of the recurrent R98S mutation in ribosomal protein L10 (RPL10-R98S) found in T-ALL. The JAK-STAT signaling pathway is a critical controller of cellular proliferation and survival. A proteome screen revealed overexpression of several Jak-Stat signaling proteins in engineered RPL10-R98S mouse lymphoid cells, which we confirmed in hematopoietic cells from transgenic Rpl10-R98S mice and T-ALL xenograft samples...
July 24, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28739302/comparison-of-the-analytical-and-clinical-performance-of-five-tests-for-the-detection-of-human-papillomavirus-genital-infection
#19
M Del Pino, I Alonso, A Trujillo, S Bernal, D Geraets, N Guimerà, A Torne, J Ordi
HPV-based screening provides greater protection against cervical cancer (CC) than cytology-based strategies. Currently, several molecular diagnostic assays for the detection of human papillomavirus (HPV) are available. In this study, we analyzed 5 different HPV testing and genotyping techniques (Hybrid Capture 2 [HC2; Qiagen, Hilden, Germany], AnyplexTMII HPV28 [Anyplex; Seegene, Seoul, Korea], Linear Array [Roche, Branchburg, NJ, USA], GP5+/6+ PCR-EIA-RH [Labo Bio-medical Products, Rijswijk, The Netherlands] and CLART2 [Genomica, Madrid, Spain]) in 295 women referred to the hospital Colposcopy Clinic from 2007 to 2008 due to positive HPV test results or an abnormal Pap test...
July 21, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28739043/pocket-detection-and-interaction-weighted-ligand-similarity-search-yields-novel-high-affinity-binders-for-myocilin-olf-a-protein-implicated-in-glaucoma
#20
Bharath Srinivasan, Sam Tonddast-Navaei, Jeffrey Skolnick
Traditional structure and ligand based virtual screening approaches rely on the availability of structural and ligand binding information. To overcome this limitation, hybrid approaches were developed that relied on extraction of ligand binding information from proteins sharing similar folds and hence, evolutionarily relationship. However, they cannot target a chosen pocket in a protein. To address this, a pocket centric virtual ligand screening approach is required. Here, we employ a new, iterative implementation of a pocket and ligand-similarity based approach to virtual ligand screening to predict small molecule binders for the olfactomedin domain of human myocilin implicated in glaucoma...
July 12, 2017: Bioorganic & Medicinal Chemistry Letters
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