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https://www.readbyqxmd.com/read/29752569/widespread-expression-of-perilipin-5-in-normal-human-tissues-and-in-diseases-is-restricted-to-distinct-lipid-droplet-subpopulations
#1
Merita Hashani, Hagen Roland Witzel, Lena Maria Pawella, Judith Lehmann-Koch, Jens Schumacher, Gunhild Mechtersheimer, Martina Schnölzer, Peter Schirmacher, Wilfried Roth, Beate Katharina Straub
Diseases associated with the accumulation of lipid droplets are increasing in western countries. Lipid droplet biogenesis, structure and degradation are regulated by proteins of the perilipin family. Perilipin 5 has been shown to regulate basal lipolysis in oxidative tissues. We examine perilipin 5 in normal human tissues and in diseases using protein biochemical and microscopic techniques. Perilipin 5 was constitutively located at small lipid droplets in skeletal myocytes, cardiomyocytes and brown adipocytes...
May 11, 2018: Cell and Tissue Research
https://www.readbyqxmd.com/read/29747820/gangliosides-and-autoimmune-peripheral-nerve-diseases
#2
John A Goodfellow, Hugh J Willison
A wide range of neuroimmunological diseases, referred to as autoimmune neuropathies, affect the peripheral nervous systems (PNS). The PNS is structurally diverse with complex anatomical compartments enriched in many different myelin and neuronal glycolipids, notably gangliosides. Autoimmune neuropathies are a proportion of autoimmune neuropathies mediated by autoimmune attack due to antibodies reactive with these compartmentally localized gangliosides. Antiganglioside antibodies are principally associated with the acute paralytic disease, Guillain-Barré syndrome, and are also found in several chronic autoimmune neuropathy syndromes...
2018: Progress in Molecular Biology and Translational Science
https://www.readbyqxmd.com/read/29746864/drug-delivery-using-polyhistidine-peptide-modified-liposomes-that-target-the-endogenous-lysosome
#3
Taiki Hayashi, Matsumi Shinagawa, Tsuyoshi Kawano, Takashi Iwasaki
Cell-penetrating peptides (CPPs) can deliver payloads into cells by forming complexes with bioactive molecules via covalent or non-covalent bonds. Various CPPs have been applied in CPP-modified liposomes, and their effectiveness is highly regarded in liposomal drug delivery systems (DDSs). Previously, we have reported on the polyhistidine peptide (H16 peptide: HHHHHHHHHHHHHHHH-NH2 ) as a new CPP. The H16 peptide has a higher cell-penetrating capacity than well-known CPPs and delivers small molecules such as fluorescent dyes, bioactive peptides, and proteins into mammalian cells...
May 7, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29719392/evaluation-of-the-potential-of-a-simplified-co-delivery-system-with-oligodeoxynucleotides-as-a-drug-carrier-for-enhanced-antitumor-effect
#4
Chunxi Liu, Tingxian Liu, Yongjun Liu, Na Zhang
Background: We previously developed a simple effective system based on oligodeoxynucleotides with CGA repeating units (CGA-ODNs) for Dox and siRNA intracellular co-delivery. Methods: In the present study, the in vitro cytotoxicity, gene transfection and in vivo safety of the co-delivery system were further characterized and discussed. Results: Compared with poly(ethyleneimine) (PEI), both CGA-ODNs and the pH-sensitive targeted coating, o -carboxymethyl-chitosan (CMCS)-poly(ethylene glycol) (PEG)-aspargine-glycine-arginine (NGR) (CMCS-PEG-NGR, CPN) showed no obvious cytotoxicity in 72 h...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29717018/medicago-plants-control-nodulation-by-regulating-proteolysis-of-the-receptor-like-kinase-dmi2
#5
Huairong Pan, Dong Wang
Plants use receptor-like kinases to monitor environmental changes and transduce signals into plant cells. The Medicago truncatula DOES NOT MAKE INFECTIONS 2 (DMI2) protein functions as a co-receptor of rhizobial signals to initiate nodule development and rhizobial infection during nitrogen-fixing symbiosis, but the mechanisms regulating DMI2 protein level and folding are still unknown. Here we report that DMI2 protein abundance changes during nitrogen-fixing symbiosis. DMI2 accumulates in the nodules and is induced by rhizobia treatment through a posttranscriptional process...
May 1, 2018: Plant Physiology
https://www.readbyqxmd.com/read/29689479/lipo-prostaglandin-e1-improves-renal-hypoxia-evaluated-by-bold-mri-in-patients-with-diabetic-kidney-disease
#6
Zhi-Cheng Li, Yu-Zhe Cai, Zhi-Gang Tang, Pan-Li Zuo, Rong-Bo Liu, Fang Liu
OBJECTIVE: To evaluate the effect of lipo-PGE1 on renal hypoxia in patients with DKD by BOLD-MRI. MATERIALS AND METHODS: All patients were divided into DKD group and CKD-without-diabetes group. All patients received intravenous 10 μg lipo-PGE1 once daily for 14 days. BOLD-MRI was performed before and after lipo-PGE1 administration to acquire renal CR2* and MR2* values. RESULTS: Renal MR2* value in DKD group after lipo-PGE1 treatment were significantly decreased compared with the baseline...
April 17, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29684791/the-role-of-promyelocytic-leukemia-protein-in-steatosis-associated-hepatic-tumors-related-to-chronic-hepatitis-b-virus-infection
#7
Yih-Lin Chung, Mei-Ling Wu
The persistence of hepatitis B surface antigen (HBsAg) is a risk factor for the development of steatosis-associated tumors in chronic hepatitis B virus (HBV) infection, yet little is known about the metabolic link with this factor. We correlated HBV-related pathogenesis in genetically engineered mice and human carriers with metabolic proteomics and lipogenic gene expression profiles. The immunohistochemistry showed that the promyelocytic leukemia protein (PML, a tumor suppressor involved in genome maintenance and fatty acid oxidation), being inversely influenced by the dynamic HBsAg levels from acute phase to seroclearance, appeared as a lipo-metabolic switch linking HBsAg-induced steatosis (lipogenesis) to HBsAg-lost fat-burning hepatocarcinogenesis (lipolysis)...
April 20, 2018: Translational Oncology
https://www.readbyqxmd.com/read/29678464/biofilm-inhibition-and-anti-candida-activity-of-a-cationic-lipo-benzamide-molecule-with-twin-nonyl-chain
#8
Tushar Jain, Prathap Reddy Muktapuram, Komal Sharma, Owk Ravi, Garima Pant, Kalyan Mitra, Surendar Reddy Bathula, Dibyendu Banerjee
A series of cationic lipo-benzamide compounds with varying lengths of hydrocarbon chains (C2M-C18M) were evaluated for anti-Candida activity. Four compounds harbouring 8-11 hydrocarbon chains demonstrated concentration-dependent inhibition of fungal cell growth with Minimum Inhibitory Concentration (MIC) of ≤6.2 µg ml-1 . The most active compound (C9M) inhibited growth of both Candida albicans and non-albicans strains and is equally active against pairs of azole sensitive and resistant clinical isolates of C...
April 12, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29619304/verifying-the-rechargeability-of-li-co-2-batteries-on-working-cathodes-of-ni-nanoparticles-highly-dispersed-on-n-doped-graphene
#9
Zhang Zhang, Xin-Gai Wang, Xu Zhang, Zhaojun Xie, Ya-Nan Chen, Lipo Ma, Zhangquan Peng, Zhen Zhou
Li-CO2 batteries could skillfully combine the reduction of "greenhouse effect" with energy storage systems. However, Li-CO2 batteries still suffer from unsatisfactory electrochemical performances and their rechargeability is challenged. Here, it is reported that a composite of Ni nanoparticles highly dispersed on N-doped graphene (Ni-NG) with 3D porous structure, exhibits a superior discharge capacity of 17 625 mA h g-1 , as the air cathode for Li-CO2 batteries. The batteries with these highly efficient cathodes could sustain 100 cycles at a cutoff capacity of 1000 mA h g-1 with low overpotentials at the current density of 100 mA g-1 ...
February 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/29616843/phase-1-trial-of-ibrutinib-and-carfilzomib-combination-therapy-for-relapsed-or-relapsed-and-refractory-multiple-myeloma
#10
Ajai Chari, Sarah Larson, Beata Holkova, Robert F Cornell, Cristina Gasparetto, Chatchada Karanes, Jeffrey V Matous, Ruben Niesvizky, Jason Valent, Matthew Lunning, Saad Z Usmani, Larry D Anderson, Lipo Chang, Yihua Lee, Yvonne Pak, Zeena Salman, Thorsten Graef, Elizabeth Bilotti, Saurabh Chhabra
This phase 1, dose-finding study investigated ibrutinib and carfilzomib ± dexamethasone in patients with relapsed or relapsed/refractory multiple myeloma (≥2 lines of therapy including bortezomib and an immunomodulatory agent). Of 43 patients enrolled, 74% were refractory to bortezomib and 23% had high-risk cytogenetics. No dose-limiting toxicities were observed. The recommended phase 2 dose was ibrutinib 840 mg and carfilzomib 36 mg/m2 with dexamethasone. The most common ≥ grade 3 (>10%) treatment-emergent adverse events were hypertension, anemia, pneumonia, fatigue, diarrhea, and thrombocytopenia...
April 4, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29615605/metal-organic-frameworks-for-precise-inclusion-of-single-stranded-dna-and-transfection-in-immune-cells
#11
Shuang Peng, Binglin Bie, Yangzesheng Sun, Min Liu, Hengjiang Cong, Wentao Zhou, Yucong Xia, Heng Tang, Hexiang Deng, Xiang Zhou
Effective transfection of genetic molecules such as DNA usually relies on vectors that can reversibly uptake and release these molecules, and protect them from digestion by nuclease. Non-viral vectors meeting these requirements are rare due to the lack of specific interactions with DNA. Here, we design a series of four isoreticular metal-organic frameworks (Ni-IRMOF-74-II to -V) with progressively tuned pore size from 2.2 to 4.2 nm to precisely include single-stranded DNA (ssDNA, 11-53 nt), and to achieve reversible interaction between MOFs and ssDNA...
April 3, 2018: Nature Communications
https://www.readbyqxmd.com/read/29605318/intravenous-lipid-infusion-affects-dry-matter-intake-methane-yield-and-rumen-bacteria-structure-in-late-lactating-holstein-cows
#12
Ole Lamp, Henry Reyer, Winfried Otten, Gerd Nürnberg, Michael Derno, Klaus Wimmers, Cornelia C Metges, Björn Kuhla
Increasing the dietary fat content of ruminant diets decreases methane (CH4 ) production. This effect is caused by the toxic properties of fatty acids on rumen microbial populations, coating of feed particles diminishing the accessibility for microbes, and a reduction in dry matter intake (DMI). The latter effect is caused by postabsorptive long-chain fatty acids eliciting anorexic signaling; however, whether circulating long-chain fatty acids affect rumen CH4 production alike is unknown. To approach this question, 5 rumen-cannulated Holstein cows in late lactation received 2 jugular catheters and were kept in respiration chambers to measure CH4 production and DMI for 48 h...
March 28, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29603449/qualitative-and-quantitative-analysis-of-lipo-alkaloids-and-fatty-acids-in-aconitum-carmichaelii-using-lc-ms-and-gc-ms
#13
Ying Liang, Guan-Yu Yan, Jian-Lin Wu, Xingxing Zong, Zhongqiu Liu, Hua Zhou, Liang Liu, Na Li
INTRODUCTION: Lipo-alkaloid (LA) is a kind of C19 -norditerpenoid alkaloid in Aconitum species, which usually contains an aconitane skeleton and one or two fatty acid residues. OBJECTIVE: To qualify and quantify the fatty acids and lipo-alkaloids in Aconitum carmichaelii. METHODOLOGY: An ultra-high performance liquid chromatography-triple quadrupole-mass spectrometry (UHPLC-QQQ-MS) method was established to quantify LAs, while the free fatty acids were identified by gas chromatography-mass spectrometry (GC-MS) and ultra-high performance liquid chromatography-quadrupole-time-of-flight-mass spectrometry (UHPLC-Q-TOF-MS)...
March 30, 2018: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/29594456/combined-pharmacotherapy-for-osteonecrosis-of-the-femoral-head-after-severe-acute-respiratory-syndrome-and-interstitial-pneumonia-two-and-a-half-to-fourteen-year-follow-up
#14
Weiguo Wang, Nianfei Zhang, Wanshou Guo, Fuqiang Gao
PURPOSE: The purpose of this study was to retrospectively analyze the clinical, functional, and radiological outcomes of combined pharmacotherapy to ONFH after high-dose corticosteroid therapy. METHOD: From August 2003 to June 2015, five patients (ten hips) of ONFH in ARCO stage I, after SARS and Interstitial pneumonia, were treated by combined pharmacotherapy. Lipo-prostaglandin E1 10 μg iv Bid × 28 days, enoxaparin 6000 iu H QD × 12 weeks, alendronate sodium tablet 10 mg QD × 1 year...
March 28, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29593951/enhanced-photodynamic-cancer-treatment-by-mitochondria-targeting-and-brominated-near-infrared-fluorophores
#15
Ilkoo Noh, DaeYong Lee, Heegon Kim, Chan-Uk Jeong, Yunsoo Lee, Jung-Oh Ahn, Hoon Hyun, Ji-Ho Park, Yeu-Chun Kim
A noninvasive and selective therapy, photodynamic therapy (PDT) is widely researched in clinical fields; however, the lower efficiency of PDT can induce unexpected side effects. Mitochondria are extensively researched as target sites to maximize PDT effects because they play crucial roles in metabolism and can be used as cancer markers due to their high transmembrane potential. Here, a mitochondria targeting photodynamic therapeutic agent (MitDt) is developed. This photosensitizer is synthesized from heptamethine cyanine dyes, which are conjugated or modified as follows...
March 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/29580727/folate-receptor-directed-orthogonal-click-functionalization-of-sirna-lipopolyplexes-for-tumor-cell-killing-in-vivo
#16
Philipp Michael Klein, Sarah Kern, Dian-Jang Lee, Johannes Schmaus, Miriam Höhn, Jan Gorges, Uli Kazmaier, Ernst Wagner
The delivery of small interfering RNA (siRNA) and its therapeutic usage as an anti-cancer agent requires a carrier system for selective internalization into the cytosol of tumor cells. We prepared folate-bearing formulations by first complexing siRNA with the novel azido-functionalized sequence-defined cationizable lipo-oligomer 1106 (containing two cholanic acids attached to an oligoaminoamide backbone in T-shape configuration) into spherical, ∼100-200 nm sized lipopolyplexes, followed by surface-functionalization with various folate-conjugated DBCO-PEG agents...
March 19, 2018: Biomaterials
https://www.readbyqxmd.com/read/29570299/ge11-directed-functional-polymersomal-doxorubicin-as-an-advanced-alternative-to-clinical-liposomal-formulation-for-ovarian-cancer-treatment
#17
Yan Zou, Yifeng Xia, Jian Zhang, Fenghua Meng, Zhiyuan Zhong
Ovarian cancer as a recurrent disease is often refractory to treatment including pegylated liposomal doxorubicin hydrochloride (Lipo-Dox). Here, GE11 peptide-modified reversibly crosslinked polymersomal doxorubicin (GE11-PS-Dox) was investigated as an advanced treatment for SKOV3 human ovarian tumor which overexpressed epidermal growth factor receptor (EGFR). The in vitro experiments using SKOV3 cancer cells demonstrated that GE11-PS-Dox induced obviously higher cellular uptake, Dox delivery to the nuclei and antitumor activity than the non-targeted PS-Dox and Lipo-Dox controls...
March 23, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29556352/the-enhanced-antitumor-specific-immune-response-with-mannose-and-cpg-odn-coated-liposomes-delivering-trp2-peptide
#18
Chunhui Lai, Siliang Duan, Fang Ye, Xiaoqiong Hou, Xi Li, Jin Zhao, Xia Yu, Zixi Hu, Zhuoran Tang, Fengzhen Mo, Xiaomei Yang, Xiaoling Lu
PURPOSE: Dendritic cell (DC)-based cancer vaccines is a newly emerging and potent form of immune therapy. As for any new technology, there are still considerable challenges that need to be addressed. Here, we investigate the antitumor potential of a novel liposomal vaccine, M/CpG-ODN-TRP2-Lipo. METHODS: We developed a vaccination strategy by assembling the DC-targeting mannose and immune adjuvant CpG-ODN on the surface of liposomes, which were loaded with melanoma-specific TRP2180-188 peptide as liposomal vaccine...
2018: Theranostics
https://www.readbyqxmd.com/read/29552851/-tissue-distribution-of-tpgs-modified-artesunate-liposome-and-its-metabolites-in-rats
#19
Cheng Hu, Kun Liang, Rui An, Xin-Hong Wang, Li-Sha You
Artesunate, which is a widely used anti-malaria medicine, can be made into liposome to overcome its poor bioactivity. Its tissue distribution in rats may change with different dosage forms, which therefore shall be studied after ARS-TPGS-Lipo was injected. Based on this experiment, ARS-TPGS-Lipo and ARS-Lipo were prepared by thin-film hydration method. LC-MS/MS method was used to simultaneously determine ARS and DHA in rat tissues at different time points. The results showed that this method was suitable for the content analysis of ARS and DHA in biological samples...
January 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29549839/antimicrobial-activity-and-self-assembly-behavior-of-antimicrobial-peptide-chensinin-1b-with-lipophilic-alkyl-tails
#20
Weibing Dong, Ziang Liu, Liying Sun, Cui Wang, Yue Guan, Xiaoman Mao, Dejing Shang
The threshold hydrophobicity and amphipathic structure of the peptidic chain are important for the biological function of antimicrobial peptides. Chensinin-1b exhibits broad-spectrum bactericidal activity with no hemolytic activity but has almost no anticancer ability against the selected cancer cell lines. In this study, the conjugation of aliphatic acid was designed with different lengths of N-terminal of chensinin-1b, the antimicrobial activity of the resulting lipo-chensinin-1b was examined, in which OA-C1b showed much stronger activity than those of cheninin-1b and the other two lipopeptides...
March 10, 2018: European Journal of Medicinal Chemistry
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