keyword
MENU ▼
Read by QxMD icon Read
search

Lipo

keyword
https://www.readbyqxmd.com/read/28935258/rifampicin-lipid-polymer-hybrid-nanoparticles-lipomer-for-enhanced-peyer-s-patch-uptake
#1
Sagar S Bachhav, Vikas D Dighe, Darsheen Kotak, Padma V Devarajan
The oral uptake of intact nanocarriers through Peyer's patches is an important uptake pathway. We report Rifampicin Lipid-Polymer hybrid nanoparticles (RIF-LIPOMER) using glyceryl monostearate as lipid and the mucoadhesive polymer, Gantrez, with the objective of balancing hydrophobicity and mucoadhesion for enhanced Peyer's patch uptake. RIF-LIPOMER was optimized for size, hydrophobicity, and mucoadhesion using Box-Behnken. Design RIF-LIPOMER (RIF-LIPO-120) exhibited average particle size in the range 300-400nm with drug loading >12%...
September 18, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28906334/tear-trough-deformity-study-of-filling-procedures-for-its-correction
#2
Michele Pascali, Davide Quarato, Marco Pagnoni, Francesco Carinci
The aim of this work is to discuss the anatomy of the tear trough region with relative danger areas, and to describe 2 different options to correct this deformity.The tear trough is a concave deformity of the orbital fat that is noticeable as a result of inherited anatomic differences and aging. However, the periorbital region is a complex area with its own septa and ligaments, fat compartments, muscles, vascularization, and lymphatic drainage and presents anatomic characteristics that must be taken into account in order to achieve good results and avoid complications...
September 12, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28890030/corpus-callosal-lipoma-extending-as-nasal-encephalocoel-cranial-lipomeningocoel
#3
Abhidha Shah, Survendra Rai, Atul Goel
A hitherto unreported case is presented wherein a 2year old child had a 'cranial lipomeningocoel' or a 'nasal lipo-encephalocoel'. The child presented with a growing mass in the base of the nose. Investigations revealed that the nasal mass was a lipoma that was an extension of intracranial lipoma. The intracranial component extended up to corpus callosum. Resection of the extracranial extension and basal reconstruction resulted in cosmetic recovery.
September 7, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28877405/egfr-targeting-and-shielding-of-pdna-lipopolyplexes-via-bivalent-attachment-of-a-sequence-defined-peg-agent
#4
Stephan Morys, Sarah Urnauer, Christine Spitzweg, Ernst Wagner
For successful nonviral gene delivery, cationic polymers are promising DNA carrier, which need to comprise several functionalities. The current work focuses on the postincorporation of epidermal growth factor receptor (EGFR) targeted PEGylation agents onto lipopolyplexes for pDNA delivery. T-shaped lipo-oligomers are previously found to be effective sequence-defined carriers for pDNA and siRNA. Here, the bis-oleoyl-oligoaminoethanamide 454 containing tyrosine trimer-cysteine ends is applied for complex formation with pDNA coding for luciferase or sodium iodide symporter (NIS)...
September 6, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28877220/attenuated-lipotoxicity-and-apoptosis-is-linked-to-exogenous-and-endogenous-augmenter-of-liver-regeneration-by-different-pathways
#5
Thomas S Weiss, Madeleine Lupke, Sara Ibrahim, Christa Buechler, Julia Lorenz, Petra Ruemmele, Ute Hofmann, Michael Melter, Rania Dayoub
Nonalcoholic fatty liver disease (NAFLD) covers a spectrum from simple steatosis to nonalcoholic steatohepatitis (NASH) and cirrhosis. Free fatty acids (FFA) induce steatosis and lipo-toxicity and correlate with severity of NAFLD. In this study we aimed to investigate the role of exogenous and endogenous ALR (augmenter of liver regeneration) for FFA induced ER (endoplasmatic reticulum) -stress and lipoapoptosis. Primary human hepatocytes or hepatoma cells either treated with recombinant human ALR (rhALR, 15kDa) or expressing short form ALR (sfALR, 15kDa) were incubated with palmitic acid (PA) and analyzed for lipo-toxicity, -apoptosis, activation of ER-stress response pathways, triacylglycerides (TAG), mRNA and protein expression of lipid metabolizing genes...
2017: PloS One
https://www.readbyqxmd.com/read/28876383/correlations-of-condition-factor-and-gonadosomatic-hepatosomatic-and-lipo-somatic-relations-of-leptodactylus-macrosternum-anura-leptodactylidae-in-the-brazilian-semi-arid
#6
Marcio F Chaves, Fernanda C M A Tenório, Igor L V L Santos, Clovis J C L, Valeria W Texeira, Geraldo J B Moura, Álvaro A C Texeira
The objective of this study was to assess variations of the condition factor (K1) in relation to the gonadosomatic- RGS and energy reserves (hepatosomatic - RWL and liposomatic - RFB relations) of Leptodactylus macrosternum and their relationship to climate variation in the Northeast of Brazil, Caatinga area, state of Paraiba. The animals were captured fortnightly through active collecting, between January and December 2013. Significant differences were observed in the monthly variations of K1, RGS and RFB indices in male and female L...
August 31, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28876013/synthesis-of-lipo-chitooligosaccharide-analogues-and-their-interaction-with-lyr3-a-high-affinity-binding-protein-for-nod-factors-and-myc-lcos
#7
Nathan Berthelot, Antoine Brossay, Virginie Gasciolli, Jean-Jacques Bono, Aurélie Baron, Jean-Marie Beau, Dominique Urban, François-Didier Boyer, Boris Vauzeilles
Lipo-chitotetrasaccharide analogues where one central GlcNAc residue was replaced by a triazole unit have been synthesized from a derivative obtained by chitin depolymerization and a functionalized N-acetyl-glucosamine via the copper-catalyzed azide-alkyne cycloaddition. Their evaluation in a binding assay using LYR3, a putative lipo-chitooligosaccharide receptor in Medicago truncatula, shows a complete loss of binding.
September 6, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28855632/resolution-agonist-15-epi-lipoxin-a4-programs-early-activation-of-resolving-phase-in-post-myocardial-infarction-healing
#8
Vasundhara Kain, Fei Liu, Veronika Kozlovskaya, Kevin A Ingle, Subhashini Bolisetty, Anupam Agarwal, Santosh Khedkar, Sumanth D Prabhu, Eugenia Kharlampieva, Ganesh V Halade
Following myocardial infarction (MI), overactive inflammation remodels the left ventricle (LV) leading to heart failure coinciding with reduced levels of 15-epi-Lipoxin A4 (15-epi LXA4). However, the role of 15-epi LXA4 in post-MI acute inflammatory response and resolving phase is unclear. We hypothesize that liposomal fusion of 15-epi-LXA4 (Lipo-15-epi-LXA4) or free 15-epi-LXA4 will expedite the resolving phase in post-MI inflammation. 8 to 12-week-old male C57BL/6 mice were subjected to permanent coronary artery ligation...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28854414/chitosan-modified-cholesterol-free-liposomes-for-improving-the-oral-bioavailability-of-progesterone
#9
Mei Wang, Meng Liu, Tingting Xie, Bing-Feng Zhang, Xiao-Li Gao
Based on the structurally similar properties of progesterone and cholesterol, chitosan-coated cholesterol-free liposomes (CS-Lipo/Prog) were formulated. CS-Lipo/Prog are spherical and uniform in size (662.1±19.3nm) with positive potential (28.19±1.97mV). The average drug entrapment efficiency (EE) is approximately 80%. The in vitro release profile of CS-Lipo/Prog shows sustained release. The in vitro stability evaluation demonstrated that CS-Lipo/Prog can efficiently shield Prog from degradation in the gastrointestinal tract...
August 24, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28827416/mixed-formulation-of-conventional-and-pegylated-meglumine-antimoniate-containing-liposomes-reduces-inflammatory-process-and-parasite-burden-in-l-infantum-infected-balb-c-mice
#10
Levi Eduardo Soares Reis, Rory Cristiane Fortes de Brito, Jamille Mirelle de Oliveira Cardoso, Fernando Augusto Siqueira Mathias, Rodrigo Dian Oliveira Aguiar Soares, Claudia Martins Carneiro, Paula Melo de Abreu Vieira, Guilherme Santos Ramos, Frédéric Jean Georges Frézard, Bruno Mendes Roatt, Alexandre Barbosa Reis
Pentavalent antimonial has been the first choice treatment for visceral leishmaniasis, however, it has several side effects that leads to low adherence to treatment. Liposome-encapsulated meglumine antimoniate (MA) arises as an important strategy for chemotherapy enhancement. Herein was evaluated the immunopathological changes using the mixture of conventional and pegylated liposomes with MA. The mice were infected with L. infantum and a single dose treatment regimen. Comparison was made with groups treated with saline, empty liposomes, free MA, and liposomal formulation of MA...
August 21, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28772071/systemic-delivery-of-folate-peg-sirna-lipopolyplexes-with-enhanced-intracellular-stability-for-in-vivo-gene-silencing-in-leukemia
#11
Dian-Jang Lee, Eva Kessel, Taavi Lehto, Xueying Liu, Naoto Yoshinaga, Kärt Padari, Ying-Chen Chen, Susanne Kempter, Satoshi Uchida, Joachim O Rädler, Margus Pooga, Ming-Thau Sheu, Kazunori Kataoka, Ernst Wagner
Protection of small interfering RNA (siRNA) against degradation and targeted delivery across the plasma and endosomal membranes to the final site of RNA interference (RNAi) are major aims for the development of siRNA therapeutics. Targeting for folate receptor (FR)-expressing tumors, we optimized siRNA polyplexes by coformulating a folate-PEG-oligoaminoamide (for surface shielding and targeting) with one of three lipo-oligoaminoamides (optionally tyrosine-modified, for optimizing stability and size) to generate ∼100 nm targeted lipopolyplexes (TLPs), which self-stabilize by cysteine disulfide cross-links...
August 24, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28740383/enhanced-immunization-via-dissolving-microneedle-array-based-delivery-system-incorporating-subunit-vaccine-and-saponin-adjuvant
#12
Ji-Hui Zhao, Qi-Bo Zhang, Bao Liu, Xiang-Hua Piao, Yu-Lu Yan, Xiao-Ge Hu, Kuan Zhou, Yong-Tai Zhang, Nian-Ping Feng
PURPOSE: To enhance the immunogenicity of the model subunit vaccine, ovalbumin (OVA) was combined with platycodin (PD), a saponin adjuvant. To reduce the toxicity of PD, OVA, and adjuvant were loaded together into liposomes before being incorporated into a dissolving microneedle array. METHODS: OVA- and PD-loaded liposomes (OVA-PD-Lipos) were prepared using the film dispersion method. Their uptake behavior, toxicity to mouse bone marrow dendritic cells (BMDCs), and hemolytic activity to rabbit red blood cells (RBCs) were evaluated...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28729031/knockout-of-the-urate-oxidase-gene-provides-a-stable-mouse-model-of-hyperuricemia-associated-with-metabolic-disorders
#13
Jie Lu, Xu Hou, Xuan Yuan, Lingling Cui, Zhen Liu, Xinde Li, Lidan Ma, Xiaoyu Cheng, Ying Xin, Can Wang, Keke Zhang, Xuefeng Wang, Wei Ren, Ruixia Sun, Zhaotong Jia, Zibin Tian, Qing-Sheng Mi, Changgui Li
The urate oxidase (Uox) gene encodes uricase that in the rodent liver degrades uric acid into allantoin, forming an obstacle for establishing stable mouse models of hyperuricemia. The loss of uricase in humans during primate evolution causes their vulnerability to hyperuricemia. Thus, we generated a Uox-knockout mouse model on a pure C57BL/6J background using the transcription activator-like effector nuclease (TALEN) technique. These Uox-knockout mice spontaneously developed hyperuricemia (over 420 μmol/l) with about 40% survival up to 62 weeks...
July 17, 2017: Kidney International
https://www.readbyqxmd.com/read/28714592/optimized-solid-phase-assisted-synthesis-of-oleic-acid-containing-sirna-nanocarriers
#14
Sören Reinhard, Wei Zhang, Ernst Wagner
Cationic lipo-oligomers containing unsaturated oleic acid are potent siRNA carriers based on electrostatic and hydrophobic lipo-polyplex formation and endosomal membrane destabilization. Lipo-oligomers can be produced by solid-phase-supported synthesis in sequence-defined form. However, the trifluoroacetic acid (TFA)-mediated removal of acid-labile protecting groups and cleavage from the resin can be accompanied by side products caused by the addition of TFA to the double bonds of oleic acid. Under aqueous conditions, these TFA adducts of oleic acid are converted into hydroxystearic acid derivatives...
September 7, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28713958/lipo%C3%A2-prostaglandin-e1-modifies-cognitive-impairment-in-rats-with-vascular-cognitive-impairment-by-promoting-angiogenesis-via-the-vegf-vegfr-pathway
#15
Bohui Liu, Suping Zhang, Xifeng Xiong, Li Ling, Rui He, Muzhen Wang, Wanqing Deng, Zhihe Liu, Yi Li
The pathological mechanism of vascular cognitive impairment (VCI) involves ischemic lesions in the hippocampus. Prostaglandin E1 (PGE1) serves roles in the promotion of vascular endothelial growth factor (VEGF) expression, angiogenesis and enhances blood flow to ischemic regions. However, the effect of PGE1 on cognitive function in VCI rats and the underlying mechanism are unknown. In the current study, learning and memory function in VCI rats treated by lipo‑PGE1 injection was assessed through Morris Water Maze test...
September 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28709223/instability-evolution-of-the-viscous-elliptic-liquid-jet-in-the-rayleigh-regime
#16
Shibo Gu, Lipo Wang, David L S Hung
For jet flow emanating from noncircular orifices, an unbalanced surface tension force leads to capillary instability, which is independent of influence from the ambient air in the Rayleigh regime. In the present article, the dynamic behavior of incompressible elliptical jets in the Rayleigh regime is investigated. Theoretically, with the consideration of the fluid viscosity, the solution of the Cosserat equation consists of a particular solution and a complementary solution. For the complementary solution the wave number of disturbance modes has two complex conjugate roots, which are responsible for the jet breakup...
June 2017: Physical Review. E
https://www.readbyqxmd.com/read/28708863/negative-modulation-of-suppressive-hiv-specific-regulatory-t-cells-by-il-2-adjuvanted-therapeutic-vaccine
#17
Vedran Brezar, Lylia Hani, Mathieu Surenaud, Audrey Hubert, Christine Lacabaratz, Jean-Daniel Lelièvre, Yves Levy, Nabila Seddiki
The potential benefit in using IL-2 in immunotherapy for cancer and autoimmunity has been linked to the modulation of immune responses, which partly relies on a direct effect on Tregs populations. Here, we revisited the role of IL-2 in HIV infection and investigated whether its use as an adjuvant with therapeutic vaccination, impacts on HIV-specific responses. Antiretroviral therapy treated-patients were randomized to receive 4 boosts of vaccination (ALVACHIV/Lipo-6T, weeks 0/4/8/12) followed by 3 cycles of IL-2 (weeks 16/24/32) before treatment interruption (TI) at week40...
July 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28694088/enhanced-expression-of-tumour-suppressor-rar-%C3%AE-by-dspc-nano-formulated-lipo-atra-in-the-lung-of-b16f10-cell-implanted-c57bl6-mice-and-in-a549-cells
#18
V M Berlin Grace, Reshma Mahima Reji, Viswanathan Sundaram
AIM: All Trans Retinoic acid (ATRA) is an efficient drug for leukemia, but is not efficient therapy for solid cancers. Hence we have used 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) and cholesterol lipo-ATRA to investigate its molecular therapeutic effect on lung cancer. The objective was to find whether it could enhance ATRA receptor, RAR-β expression in lung cells as it was lost in majority of cancers including lung cancer. MATERIALS AND METHODS: The study was made in an experimental C57BL/6 mice model developed by tail vein injection of B16F10 cells and in A549 human lung cancer cells...
September 1, 2017: Life Sciences
https://www.readbyqxmd.com/read/28683925/a-further-result-on-consensus-problems-of-second-order-multi-agent-systems-with-directed-graphs-a-moving-mode-and-multiple-delays
#19
Xue Li, Kai Gao, Peng Lin, Lipo Mo
This paper considers a consensus problem of a class of second-order multi-agent systems with a moving mode and multiple delays on directed graphs. Using local information, a distributed algorithm is adopted to make all agents reach a consensus while moving together with a constant velocity in the presence of delays. To study the effects of the coexistence of the moving mode and delays on the consensus convergence, a frequency domain approach is employed through analyzing the relationship between the components of the eigenvector associated with the eigenvalue on imaginary axis...
July 3, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28672000/synthesis-and-evaluation-of-l-arabinose-based-cationic-glycolipids-as-effective-vectors-for-pdna-and-sirna-in-vitro
#20
Bo Li, Wanrong Guo, Fan Zhang, Meiyan Liu, Shang Wang, Zhonghua Liu, Shuanglin Xiang, Youlin Zeng
Glycolipids might become a new type of promising non-viral gene delivery systems because of their low cytotoxicity, structural diversity, controllable aqua- and lipo-solubility, appropriate density and distribution of positive charges, high transfer efficiency and potential targeting function. In this study, four kinds of L-arabinose-based cationic glycolipids (Ara-DiC12MA, Ara-DiC14MA, Ara-DiC16MA and Ara-DiC18MA) containing quaternary ammonium as hydrophilic headgroup and two alkane chains as hydrophobic domain were synthesized and characterized...
2017: PloS One
keyword
keyword
21038
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"