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https://www.readbyqxmd.com/read/28219808/photoluminescent-and-biodegradable-polycitrate-polyethylene-glycol-polyethyleneimine-polymers-as-highly-biocompatible-and-efficient-vectors-for-bioimaging-guided-sirna-and-mirna-delivery
#1
Min Wang, Yi Guo, Meng Yu, Peter X Ma, Cong Mao, Bo Lei
: Development of biodegradable and biocompatible non-viral vectors with intrinsical multifunctional properties such as bioimaging ability for highly efficient nucleic acids delivery still remains a challenge. Here, a biodegradable poly (1, 8-octanedio-citric acid)-co-polyethylene glycol grafted with polyethyleneimine (PEI) (POCG-PEI) polymers with the photoluminescent capacity were synthesized for nucleic acids delivery (siRNA and miRNA). POCG-PEI polymers can efficiently bind various nucleic acids, protect them against enzymatic degradation and release the genes in the presence of polyanionic heparin...
February 17, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28193011/optimization-of-an-anti-poly-ethylene-glycol-anti-peg-cell-based-capture-system-to-quantify-peg-and-pegylated-molecules
#2
Wen-Wei Lin, Yuan-Chin Hsieh, Yi-An Cheng, Kuo-Hsiang Chuang, Chien-Chiao Huang, Chih-Hung Chuang, I-Ju Chen, Kai-Wen Cheng, Yun-Chi Lu, Ta-Chun Cheng, Yeng-Tseng Wang, Steve R Roffler, Tian-Lu Cheng
Sensitive determination of the pharmacokinetics of PEGylated molecules can accelerate the process of drug development. Here, we combined different anti-PEG Fab expressing 293T cells as capture cells (293T/3.3, 293T/6.3, and 293T/15-2b cells) with four detective anti-PEG antibodies (3.3, 6.3, 7A4, or 15-2b) to optimize an anti-PEG cell-based sandwich ELISA. Then, we quantified free PEG (mPEG2K-NH2 and mPEG5K-NH2) or PEG-conjugated small molecules (mPEG5K-biotin and mPEG5K-NIR797), proteins (PegIntron and Pegasys), and nanoparticles (Liposomal-Doxorubicin and quantum-dots)...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28167263/asialoglycoprotein-receptor-targeted-liposomes-loaded-with-a-norcantharimide-derivative-for-hepatocyte-selective-targeting
#3
Xiaolin Liu, Mengting Han, Jiawen Xu, Sicong Geng, Yu Zhang, Xaohui Ye, Jingxin Gou, Tian Yin, Haibing He, Xing Tang
In order to overcome the shortcomings associated with the clinical application of norcantharidin (NCTD), including intense irritation and a short half-life, and to obtain a hepatocyte-selective liposome system with high encapsulation efficiency (EE) and low leakage, we synthesized a C14 alkyl chain norcantharimide derivative of NCTD (2-tetradecylhexahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione, N-14NCTDA). Asialoglycoprotein receptor-targeted, galactosylated liposomes loaded with N-14NCTDA (GAL-Lipo) were prepared by the lipid film hydration method...
February 4, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28159300/attenuation-of-alpha-naphthylisothiocyanate-anit-induced-biliary-fibrosis-by-depletion-of-hepatic-macrophages-in-rats
#4
Hossain M Golbar, Takeshi Izawa, Alexandra Bondoc, Kavindra K Wijesundera, Anusha H Tennakoon, Mitsuru Kuwamura, Jyoji Yamate
Biliary fibrosis is a complex process in which macrophages and myofibroblasts may play central roles. We investigated biliary fibrosis lesions induced in the Glisson's sheath in rats by alpha-naphthylisothiocyanate (ANIT) administration under macrophage depletion. Hepatic macrophages were depleted in F344 rats with liposome-encapsulated clodronate (CLD) (10mL/kg body weight, i.v) followed by bile duct injury with ANIT (75mg/kg body weight, i.p) (ANIT+CLD group). Rats received empty-liposomes (Lipo) followed by ANIT, and served as control (ANIT+Lipo group)...
January 31, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28156162/contribution-of-both-olfactory-and-systemic-pathways-for-brain-targeting-of-nimodipine-loaded-lipo-pluronics-micelles-in-vitro-characterization-and-in-vivo-biodistribution-study-after-intranasal-and-intravenous-delivery
#5
COMPARATIVE STUDY
Hassan M Rashed, Rehab N Shamma, Emad B Basalious
Nimodipine (NM) is the only FDA-approved drug for treating subarachnoid hemorrhage induced vasospasm. NM has poor oral bioavailability (5-13%) due to its low aqueous solubility, and extensive first pass metabolism. The objective of this study is to develop radiolabeled NM-loaded LPM and to test its ability prolong its circulation time, reduce its frequency of administration and eventually target it to the brain tissue. NM was radiolabeled with (99m)Tc by direct labeling method using sodium dithionite. Different reaction conditions that affect the radiolabeling yield were studied...
November 2016: Drug Delivery
https://www.readbyqxmd.com/read/28137468/the-vector-related-influences-of-autophagic-microrna-delivery-by-lipofectamine-2000-and-polyethylenimine-25k-on-mouse-embryonic-fibroblast-cells
#6
Chia-Wei Lin, Ming-Shiou Jan, Jung-Hua Steven Kuo
Despite the greater potential for clinical applications of autophagic microRNA (miRNA) delivery, the vector-related effects of such delivery on cells have not been fully explored. In this study, autophagic mmu-miR-494-3p (miR-494) in mouse embryonic fibroblast (MEF) cells was selected as a cargo miRNA, and two commonly used non-viral carriers (Lipofectamine 2000 (Lipo) and polyethylenimine 25K (PEI)), were used as delivery vectors to mechanistically elucidate its vector-related effects. The cellular uptake, nuclear localization, and quantitative miR-494 levels of the complexes of miR-494 with Lipo (miR-494 lipoplexes) were lower than those of the complexes of miR-494 with PEI (miR-494 polyplexes) in MEF cells...
January 27, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28129977/synthesis-of-cholesteryl-doxorubicin-and-its-anti-cancer-activity
#7
Jong-Soo Choi, Kyung-Oh Doh, Bieong-Kil Kim, Young-Bae Seu
Doxorubicin (dox) has been used as anti-cancer agent, but there are disadvantages such as rapid excretion, short retention time and cardiotoxicity. For giving lipophilic properties to dox, it was modified with cholesterol derivatives that were validated as a component of liposomal gene delivery. This article describes the synthesis of dox derivatives (lipo-dox A-D), their cytotoxicity and cellular uptake. In A549, HeLa, MCF7 and MDA MB 231 cell lines, lipo-dox A and lipo-dox B substituted at alcohol group showed similar anti-cancer effect as dox, but lipo-dox C and lipo-dox D substituted at amino group did not...
January 17, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28117020/membrane-active-antimicrobial-peptides-as-template-structures-for-novel-antibiotic-agents
#8
REVIEW
Karl Lohner
The increase of pathogens being resistant to antibiotics represents a global health problem and therefore it is a pressing need to develop antibiotics with novel mechanisms of action. Host defense peptides, which have direct antimicrobial activity (also termed antimicrobial peptides) or immune modulating activity, are valuable template structures for the development of such compounds. Antimicrobial peptides exhibit remarkably different structures as well as biological activity profiles with multiple targets...
2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28098869/core%C3%A2-shell-lipid-polymer-nanoparticles-for-combined-chemo%C3%A2-and-gene-therapy-of-childhood-head-and-neck-cancers
#9
Tiesong Zhang, Jing Ma, Chao Li, Ken Lin, Fan Lou, Hongchao Jiang, Yingqin Gao, Yanli Yang, Cheng Ming, Biao Ruan
Pediatric head and neck cancers account for overall 12% of all pediatric cancers. Despite recent advances in therapeutic modalities, children with tumor metastasis have poor prognosis. Therefore, there is an unmet need for new and effective treatment modalities for pediatric head and neck cancers. The present study describes a simple and efficient method for fabrication of cationic lipid‑polymer hybrid nanoparticles (CLPNs) for co‑delivery of cisplatin (CDDP) and DNA (CDDP/DNA CLPNs) for the therapy of childhood head and neck cancers...
January 13, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28055201/tumor-microenvironment-sensitive-liposomes-penetrate-tumor-tissue-via-attenuated-interaction-of-the-extracellular-matrix-and-tumor-cells-and-accompanying-actin-depolymerization
#10
Satoko Suzuki, Shoko Itakura, Ryo Matsui, Kayoko Nakayama, Takayuki Nishi, Akinori Nishimoto, Susumu Hama, Kentaro Kogure
Delivery of anticancer drugs into tumor cores comprised of malignant cancer cells can result in potent therapeutic effects. However, conventional nanoparticle-based drug delivery systems used for cancer therapy often exhibit inefficient tumor-penetrating properties, thus, suggesting the need to improve the functional design of such systems. Herein, we focus on the interactions between cancer cells and the extracellular matrix (ECM) and demonstrate that liposomes modified with slightly acidic pH-sensitive peptide (SAPSp-lipo) can penetrate in vivo tumor tissue and in vitro spheroids comprised of cancer cells and ECM...
January 19, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28033704/disruption-of-mycobacterial-aftb-results-in-complete-loss-of-terminal-%C3%AE-1-%C3%A2-2-arabinofuranose-residues-of-lipoarabinomannan
#11
Monika Jankute, Luke J Alderwick, Stephan Noack, Natacha Veerapen, Jérôme Nigou, Gurdyal S Besra
Lipoarabinomannan (LAM) and arabinogalactan (AG) are the two major mycobacterial cell wall (lipo)polysaccharides, which contain a structurally similar arabinan domain that is highly branched and assembled in a stepwise fashion by variety of arabinofuranosyltransferases (ArafT). In addition to playing an essential role in mycobacterial physiology, LAM and its biochemical precursor lipomannan possess potent immunomodulatory activities that affect the host immune response. In the search of additional mycobacterial ArafTs that participate in the synthesis of the arabinan segment of LAM, we disrupted aftB (MSMEG_6400) in Mycobacterium smegmatis...
January 20, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28027231/the-lipo-body-lift-a-new-circumferential-body-contouring-technique-useful-after-bariatric-surgery
#12
Nicolas Bertheuil, Benoit Chaput, Antoine De Runz, Paul Girard, Raphael Carloni, Eric Watier
BACKGROUND: After bariatric surgery, lifting of the lower body involves a contouring technique used to achieve optimal lower trunk reconstruction. The authors describe an innovative procedure applicable after massive weight loss: the lipo-body lift method. The authors describe their experience with this novel, safe procedure. METHODS: Twenty-five abdominal body-contouring reconstructions following massive weight loss were treated by means of circumferential lipo-body lift...
January 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28002510/caspase-3-expression-and-plasma-level-of-fas-ligand-as-apoptosis-biomarkers-in-inflammatory-endotoxemic-lung-injury
#13
Raluca Ştefania Fodor, Anca Meda Georgescu, Bianca Liana Grigorescu, Adrian Dan Cioc, Mihaly Veres, Ovidiu Simion Cotoi, Pal Fodor, Sanda Maria Copotoiu, Leonard Azamfirei
OBJECTIVE: The objective of this study is to evaluate if the immunohistochemical expression of a pulmonary apoptosis marker and plasma level of Fas ligand (FasL) correlates with the dose- and time-dependent severity of lung injury, induced by the administration of lipo-polysaccharide (LPS) in an endotoxemic rat model. MATERIALS AND METHODS: Our study included 30 male Wistar rats, randomly divided into three groups: one control group (n=6) and two experimental groups (n=12÷group), in whom we induced endotoxemia by intraperitoneal injection of progressively increasing doses of LPS (5, 10 mg÷kg)...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27991598/using-anti-poly-ethylene-glycol-bioparticles-for-the-quantitation-of-pegylated-nanoparticles
#14
Yuan-Chin Hsieh, Ta-Chun Cheng, Hsin-Ell Wang, Jia-Je Li, Wen-Wei Lin, Chien-Chiao Huang, Chih-Hung Chuang, Yeng-Tseng Wang, Jaw-Yuan Wang, Steve R Roffler, Kuo-Hsiang Chuang, Tian-Lu Cheng
Attachment of polyethylene glycol (PEG) molecules to nanoparticles (PEGylation) is a widely-used method to improve the stability, biocompatibility and half-life of nanomedicines. However, the evaluation of the PEGylated nanomedicine pharmacokinetics (PK) requires the decomposition of particles and purification of lead compounds before analysis by high performance liquid chromatography (HPLC), mass spectrometry, etc. Therefore, a method to directly quantify un-decomposed PEGylated nanoparticles is needed. In this study, we developed anti-PEG bioparticles and combined them with anti-PEG antibodies to generate a quantitative enzyme-linked immunosorbent assay (ELISA) for direct measurement of PEGylated nanoparticles without compound purification...
December 19, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27983855/nir-light-activated-drug-release-for-synergetic-chemo-photothermal-therapy
#15
Ahu Yuan, Wei Huan, Xiang Liu, Zhicheng Zhang, Yifan Zhang, Jinhui Wu, Yiqiao Hu
Nanocarriers like PEGylated liposomes have achieved enhanced drug accumulation in tumors and reduced systemic side effects, but failed to actively release the carried drug into cancer cells. To obtain improved therapeutic efficacy, we designed a novel liposome that was inserted by the amphiphilic agent PEG-IR780-C13 (PIC-Lipo) and encapsulated therapeutic agent doxorubicin (DOX), termed as DOX@PIC-Lipo. Upon NIR laser irradiation, the novel liposomes could generate hyperthermia and facilitate the release of encapsulated DOX from PIC-Lipo, which were confirmed by photothermal curves and the DOX release assay in vitro, respectively...
January 3, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/27981593/determination-of-isoflavone-genistein-and-daidzein-concentration-of-soybean-seed-as-affected-by-environment-and-management-inputs
#16
Randy Laurenz, Pavani Tumbalam, Seth Naeve, Kurt D Thelen
BACKGROUND: Isoflavones, such as genistein and daidzein, are produced in soybean seed [Glycine max (L.) Merr.] and may be associated with health benefits in the human diet. More research is required to determine the effect of agronomic soybean treatments on isoflavone concentration. In this study from 2012 to 2014 at Michigan State University and Breckenridge locations, we have evaluated agronomic input management systems which are marketed to increase or protect potential soybean grain yield, including: nitrogen fertilization, herbicide-defoliant, foliar applied fertilizer, a biological-based foliar application, foliar applied fungicide, foliar applied insecticide, a seed applied fungicide, and a maximized seed treatment that included fungicide and insecticide as well as an inoculant and lipo-chitooligosaccharide nodulation promoter, for their effect on soybean seed genistein and daidzein concentrations...
December 16, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27975504/steam-and-fermentation-processing-could-exert-the-anti-oxidant-and-anti-inflammatory-activities-of-gastrodiae-rhizoma-in-lipo-poly-saccharide-induced-mice
#17
A R Lee, J Y Lee, M Y Kim, M R Shin, S H Shin, S S Roh
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27925179/hepatoma-cell-functions-modulated-by-nek2-are-associated-with-liver-cancer-progression
#18
Sheng-Ming Wu, Syuan-Ling Lin, Kang-Yun Lee, Hsiao-Chi Chuang, Po-Hao Feng, Wan-Li Cheng, Chia-Jung Liao, Hsiang-Cheng Chi, Yang-Hsiang Lin, Chung-Ying Tsai, Wei-Jan Chen, Chau-Ting Yeh, Kwang-Huei Lin
NEK2 (NIMA-related expressed kinase 2) is a serine/threonine centrosomal kinase that acts as a critical regulator of centrosome structure and function. Aberrant NEK2 activities lead to failure in regulating centrosome duplication. NEK2 overexpression promotes tumorigenesis and is associated with poor prognosis in several cancers. Increased NEK2 expression during the late pathological stage has been detected in the Oncomine liver dataset and hepatocellular carcinoma (HCC) specimens. Elevated NEK2 protein is associated with poor overall survival in patients with HCC...
April 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27922949/the-neurological-safety-of-an-epidurally-administered-lipo-pge1-agonist-in-rats
#19
Eunjoo Choi, Sun Min Im, Hyung-Seok Yoo, Francis Sahngun Nahm, Yang Hyun Kim, Gheeyoung Choe, Pyung Bok Lee
BACKGROUND AND OBJECTIVE: Liposomal prostaglandin E1 (Lipo-PGE1) can inhibit platelet aggregation and vasodilatation and has been found to be therapeutic in ischemia and spinal diseases including stenosis. However, the neurologic safety of epidural administration of lipo-PGE1 requires further study. We investigated the neurotoxicity of epidurally administered lipo-PGE1 agonist in rats. METHODS: Twenty-seven rats were randomly divided into three groups: Epidural isotonic sodium chloride solution administration (negative control, group N, n = 9); epidural lipo-PGE1 agonist (group L, n = 9); and epidural alcohol (positive control, group A, n = 9)...
January 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/27893636/facial-contouring-by-targeted-restoration-of-facial-fat-compartment-volume-the-mid-face
#20
Wenjin Wang, Yun Xie, Ru-Lin Huang, Jia Zhou, Herrler Tanja, Peijuan Zhao, Chen Cheng, Sizheng Zhou, Lee L Q Pu, Qingfeng Li
BACKGROUND: Recent anatomical findings have suggested that facial fat distribution is complex and changes with age. Here, we developed a grafting technique based on the physiological distribution and volume changes of facial fat compartments to achieve a youthful and natural-looking face. METHODS: Forty cadaveric hemifaces were used for the dissection of fat compartments and neurovascular structures in the mid-face area. Seventy-eight patients were treated for cheek atrophy using our targeted restoration of mid-face fat compartment volume...
November 21, 2016: Plastic and Reconstructive Surgery
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