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https://www.readbyqxmd.com/read/29129657/transport-mechanism-of-lipid-covered-saquinavir-pure-drug-nanoparticles-in-intestinal-epithelium
#1
Dengning Xia, Yuan He, Qiuxia Li, Cunde Hu, Wei Huang, Yunhai Zhang, Feng Wan, Chi Wang, Yong Gan
Pure drug nanoparticles (NPs) represent a promising formulation for improved drug solubility and controlled dissolution velocity. However, limited absorption by the intestinal epithelium remains challenge to their clinical application, and little is known about how these NPs within the cells are transported. To improve cellular uptake and transport of pure nanodrug in cells, here, a lipid covered saquinavir (SQV) pure drug NP (Lipo@nanodrug) was designed by modifying a pure SQV NP (nanodrug) with a phospholipid bilayer...
November 9, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29129572/biocompatible-fluorinated-poly-%C3%AE-amino-ester-s-for-safe-and-efficient-gene-therapy
#2
Jia-Hui Gong, Yi Wang, Lei Xing, Peng-Fei Cui, Jian-Bin Qiao, Yu-Jing He, Hu-Lin Jiang
Cationic polymers have been widely used as one of the most promising non-viral vehicles for gene delivery due to their potential safety and ease of large-scale production. Here, we report the design and synthesis of a series of novel biodegradable fluorinated poly(β-amino ester)s (FPBAEs) by simple Michael-addition reaction as safe and efficient gene carrier. The results of transfection efficacy assay demonstrated the optimal FPBAE could mediated much higher GFP expression than the commercial transfection agents, polyethyleneimine (PEI, Mw = 25K) and Lipo 2000, as well as the non-fluorinated poly(β-amino ester)s (PBAE) on both HeLa and HEK-293T cell lines (higher than 70 and 90%, respectively), which was largely attributed to fluorination...
November 10, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29120820/development-of-pegylated-aspartic-acid-modified-liposome-as-a-bone-targeting-carrier-for-the-delivery-of-paclitaxel-and-treatment-of-bone-metastasis
#3
Shugo Yamashita, Hidemasa Katsumi, Nozomi Hibino, Yugo Isobe, Yumiko Yagi, Yuka Tanaka, Saki Yamada, Chihiro Naito, Akira Yamamoto
To prevent bone metastasis, we developed polyethylene glycol (PEG)-conjugated aspartic acid (Asp)-modified liposomes (PEG-Asp-Lipo) as a bone-targeting carrier of paclitaxel (PTX) by using Asp-modified 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE-Asp). The affinity of Asp-modified liposomes to hydroxyapatite increased as the concentration of DPPE-Asp increased. The bone accumulation of [(3)H]-labeled PEG(2)-Asp(33)-Lipo was approximately 24.6% 360 min after intravenous injection in mice, in contrast to 5...
October 31, 2017: Biomaterials
https://www.readbyqxmd.com/read/29109030/layer-by-layer-assembly-of-graphene-oxide-on-thermosensitive-liposomes-for-photo-chemotherapy
#4
Mohadeseh Hashemi, Meisam Omidi, Bharadwaj Muralidharan, Lobat Tayebi, Matthew J Herpin, Mohammad Ali Mohagheghi, Javad Mohammadi, Hugh D C Smyth, Thomas E Milner
Stimuli responsive polyelectrolyte nanoparticles have been developed for chemo-photothermal destruction of breast cancer cells. This novel system, called layer by layer Lipo-graph (LBL Lipo-graph), is composed of alternate layers of graphene oxide (GO) and graphene oxide conjugated poly (l-lysine) (GO-PLL) deposited on cationic liposomes encapsulating doxorubicin. Various concentrations of GO and GO-PLL were examined and the optimal LBL Lipo-graph was found to have a particle size of 267.9 ± 13 nm, zeta potential of +43...
November 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29076804/chain-length-specific-anti-candida-activity-of-cationic-lipo-oxazoles-a-new-class-of-quaternary-ammonium-compounds
#5
Tushar Jain, Pratap Reddy Muktapuram, Satyanarayana Pochampalli, Komal Sharma, Garima Pant, Kalyan Mitra, Surendar Reddy Bathula, Dibyendu Banerjee
PURPOSE: Candida species have become resistant to commonly used anti-fungal drugs like fluconazole and echinocandins. In our screen, a series of quaternary ammonium compounds (QACs) emerged as an alternative treatment choice for drug-resistant Candida infections. METHODOLOGY: Medium alkyl chain cationic lipo-oxazoles comprising six to thirteen twin carbon chains and a quaternary ammonium unit were synthesized and evaluated for their in vitro anti-Candida and biofilm inhibition activity...
October 27, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29074882/liposome-encapsulated-plasmid-dna-of-telomerase-specific-oncolytic-adenovirus-with-stealth-effect-on-the-immune-system
#6
Katsuyuki Aoyama, Shinji Kuroda, Toshiaki Morihiro, Nobuhiko Kanaya, Tetsushi Kubota, Yoshihiko Kakiuchi, Satoru Kikuchi, Masahiko Nishizaki, Shunsuke Kagawa, Hiroshi Tazawa, Toshiyoshi Fujiwara
Oncolytic virotherapy has the disadvantage of being unsuitable for systemic delivery due to immune elimination. Liposomal encapsulation is well-recognized to reduce immune elimination and enhance the stability of drugs in the bloodstream. In the present study, the potential of liposome-encapsulated plasmid DNA of telomerase-specific oncolytic adenovirus (TelomeScan) expressing GFP (Lipo-pTS) as an oncolytic adenoviral agent suitable for systemic delivery was investigated. Lipo-pTS, which has a diameter of 40-50 nm, showed potent antitumor effects on HCT116 colon carcinoma cells in vitro and in vivo...
October 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29069340/in-vitro-attenuation-of-a-virulent-swine-isolate-of-brachyspira-hampsonii
#7
Jason Byron D S Perez, Champika Fernando, Roman V Nosach, Yanyun Huang, John C S Harding, Janet E Hill
'Brachyspira hampsonii ' causes dysentery-like disease in infected pigs. Serial passage of a virulent swine isolate (P13) one-hundred times in laboratory culture medium was conducted to produce an attenuated strain, and to identify genomic determinants of virulence through comparison of genome sequences of the original and passaged strains. The resulting strain, P113, did not differ from P13 in terms of diagnostic biochemical characteristics, but had an enhanced growth rate in culture, indicating laboratory adaptation...
October 24, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/29060282/a-wireless-optical-power-system-for-medical-implants-using-low-power-near-ir-laser
#8
A Saha, S Iqbal, M Karmaker, S F Zinnat, M T Ali
An alternative method of transcutaneous wireless optical energy supply to an artificial cardiac pacemaker has been conceived, thereby negating the possibility of electromagnetic interference. In this research, a comparative analysis is made between two distinct arrays of photovoltaic cells, consisting of two different geometries. Being powered by a 5 mW 750 nm laser, that has a different spot size for each topology; both models are tested by their ability to charge a 150 mAh rechargeable LiPo battery, while being embedded underneath a layer of skin tissue...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29054682/liposomalization-of-oxaliplatin-induces-skin-accumulation-of-it-but-negligible-skin-toxicity
#9
Kentaro Nishida, Misaki Kashiwagi, Shunsuke Shiba, Kiwamu Muroki, Akihiro Ohishi, Yusuke Doi, Hidenori Ando, Tatsuhiro Ishida, Kazuki Nagasawa
Liposomalization causes alteration of the pharmacokinetics of encapsulated drugs, and allows delivery to tumor tissues through passive targeting via an enhanced permeation and retention (EPR) effect. PEGylated liposomal doxorubicin (Doxil(®), Lipo-DXR), a representative liposomal drug, is well-known to reduce cardiotoxicity and increase the anti-tumor activity of DXR, but to induce the hand-foot syndrome (HFS) as a result of skin DXR accumulation, which is one of its severe adverse effects. We have developed a new liposomal preparation of oxaliplatin (l-OHP), an important anti-tumor drug for treatment of colorectal cancer, using PEGylated liposomes (Lipo-l-OHP), and showed that Lipo-l-OHP exhibits increased anti-tumor activity in tumor-bearing mice compared to the original preparation of l-OHP...
October 17, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29035307/effects-of-three-lipidated-oxytocin-analogs-on-behavioral-deficits-in-cd38-knockout-mice
#10
Stanislav M Cherepanov, Shirin Akther, Tomoko Nishimura, Anna A Shabalova, Akira Mizuno, Wataru Ichinose, Satoshi Shuto, Yasuhiko Yamamoto, Shigeru Yokoyama, Haruhiro Higashida
Oxytocin (OT) is a nonapeptide that plays an important role in social behavior. Nasal administration of OT has been shown to improve trust in healthy humans and social interaction in autistic subjects. As is consistent with the nature of a peptide, OT has some unfavorable characteristics: it has a short half-life in plasma and shows poor permeability across the blood-brain barrier. Analogs with long-lasting effects may overcome these drawbacks. To this end, we have synthesized three analogs: lipo-oxytocin-1 (LOT-1), in which two palmitoyl groups are conjugated to the cysteine and tyrosine residues, lipo-oxytocin-2 (LOT-2) and lipo-oxytocin-3 (LOT-3), which include one palmitoyl group conjugated at the cysteine or tyrosine residue, respectively...
October 16, 2017: Brain Sciences
https://www.readbyqxmd.com/read/29030307/egfr-targeted-multifunctional-polymersomal-doxorubicin-induces-selective-and-potent-suppression-of-orthotopic-human-liver-cancer-in-vivo
#11
Yuan Fang, Weijing Yang, Liang Cheng, Fenghua Meng, Jian Zhang, Zhiyuan Zhong
Liver cancer is a globally leading malignancy that has a poor five-year survival rate of less than 20%. The systemic chemotherapeutics are generally ineffective for liver cancers partly due to fast clearance and low tumor uptake. Here, we report that GE11 peptide functionalized polymersomal doxorubicin (GE11-PS-DOX) effectively targets and inhibits epidermal growth factor receptor (EGFR)-positive SMMC7721 orthotopic human liver tumor xenografts in mice. GE11-PS-DOX with a GE11 surface density of 10% displayed a high drug loading of 15...
December 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28994235/lipo-protein-emulsion-structure-in-the-diet-affects-protein-digestion-kinetics-intestinal-mucosa-parameters-and-microbiota-composition
#12
Marion Oberli, Véronique Douard, Martin Beaumont, Daphné Jaoui, Fabienne Devime, Sandy Laurent, Catherine Chaumontet, Damien Mat, Steven Le Feunteun, Camille Michon, Anne-Marie Davila, Gilles Fromentin, Daniel Tomé, Isabelle Souchon, Marion Leclerc, Claire Gaudichon, François Blachier
SCOPE: Food structure is a key factor controlling digestion and nutrient absorption. We tested the hypothesis that protein emulsion structure in the diet may affect digestive and absorptive processes. METHODS & RESULTS: Rats (n = 40) were fed for 3 weeks two diets chemically identical but based on lipid-protein liquid-fine (LFE) or gelled-coarse (GCE) emulsions that differ at the macro- and micro-structure levels. After an overnight fasting, they ingested a (15) N-labeled LFE or GCE test meal and were euthanized 0, 15min, 1h and 5h later...
October 10, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28992509/liposomes-coated-gold-nanocages-with-antigens-and-adjuvants-targeted-delivery-to-dendritic-cells-for-enhancing-antitumor-immune-response
#13
Ruijing Liang, Jun Xie, Jun Li, Ke Wang, Liping Liu, Yujie Gao, Mubashir Hussain, Guanxin Shen, Jintao Zhu, Juan Tao
For nanovaccine-based cancer immunotherapy, dendritic cells (DCs) are one of the most powerful antigen presenting cells (APCs) that initiate and promote the maturation of antigen-specific cytotoxic T lymphocytes (e.g., CD8(+) T cells) to induce the local and systemic antitumor immunity and further suppress the tumor metastasis and produce long-term protection against tumor. Thus, the activation and maturation of DCs is the prerequisite for efficient CD8(+) T cell-based antitumor immune responses, which is considered as a primary and promising task for nanovaccine engineering...
September 26, 2017: Biomaterials
https://www.readbyqxmd.com/read/28966099/a-comparison-study-between-lycobetaine-loaded-nanoemulsion-and-liposome-using-nrgd-as-therapeutic-adjuvant-for-lung-cancer-therapy
#14
Tijia Chen, Ting Gong, Ting Zhao, Yao Fu, Zhirong Zhang, Tao Gong
To achieve tumor-selective drug delivery, various nanocarriers have been explored using either passive or active targeting strategies. Despite the great number of studies published annually in the field, only nanocarriers using approved excipients reach the clinical stage. In our study, two classic nanoscale formulations, nanoemulsion (NE) and liposome (Lipo) were selected for the encapsulation of lycobetaine (LBT). To improve the lipid solubility of LBT, oleic acid (OA) was used to complex (LBT-OA) with lycobetaine (LBT)...
September 28, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28935258/rifampicin-lipid-polymer-hybrid-nanoparticles-lipomer-for-enhanced-peyer-s-patch-uptake
#15
Sagar S Bachhav, Vikas D Dighe, Darsheen Kotak, Padma V Devarajan
The oral uptake of intact nanocarriers through Peyer's patches is an important uptake pathway. We report Rifampicin Lipid-Polymer hybrid nanoparticles (RIF-LIPOMER) using glyceryl monostearate as lipid and the mucoadhesive polymer, Gantrez, with the objective of balancing hydrophobicity and mucoadhesion for enhanced Peyer's patch uptake. RIF-LIPOMER was optimized for size, hydrophobicity, and mucoadhesion using Box-Behnken. Designed RIF-LIPOMER (RIF-LIPO-120) exhibited average particle size in the range 300-400nm with drug loading >12%...
September 19, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28906334/tear-trough-deformity-study-of-filling-procedures-for-its-correction
#16
Michele Pascali, Davide Quarato, Marco Pagnoni, Francesco Carinci
The aim of this work is to discuss the anatomy of the tear trough region with relative danger areas, and to describe 2 different options to correct this deformity.The tear trough is a concave deformity of the orbital fat that is noticeable as a result of inherited anatomic differences and aging. However, the periorbital region is a complex area with its own septa and ligaments, fat compartments, muscles, vascularization, and lymphatic drainage and presents anatomic characteristics that must be taken into account in order to achieve good results and avoid complications...
November 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28890030/corpus-callosal-lipoma-extending-as-nasal-encephalocoel-cranial-lipomeningocoel
#17
Abhidha Shah, Survendra Rai, Atul Goel
A hitherto unreported case is presented wherein a 2year old child had a 'cranial lipomeningocoel' or a 'nasal lipo-encephalocoel'. The child presented with a growing mass in the base of the nose. Investigations revealed that the nasal mass was a lipoma that was an extension of intracranial lipoma. The intracranial component extended up to corpus callosum. Resection of the extracranial extension and basal reconstruction resulted in cosmetic recovery.
November 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28877405/egfr-targeting-and-shielding-of-pdna-lipopolyplexes-via-bivalent-attachment-of-a-sequence-defined-peg-agent
#18
Stephan Morys, Sarah Urnauer, Christine Spitzweg, Ernst Wagner
For successful nonviral gene delivery, cationic polymers are promising DNA carrier, which need to comprise several functionalities. The current work focuses on the postincorporation of epidermal growth factor receptor (EGFR) targeted PEGylation agents onto lipopolyplexes for pDNA delivery. T-shaped lipo-oligomers are previously found to be effective sequence-defined carriers for pDNA and siRNA. Here, the bis-oleoyl-oligoaminoethanamide 454 containing tyrosine trimer-cysteine ends is applied for complex formation with pDNA coding for luciferase or sodium iodide symporter (NIS)...
September 6, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28877220/attenuated-lipotoxicity-and-apoptosis-is-linked-to-exogenous-and-endogenous-augmenter-of-liver-regeneration-by-different-pathways
#19
Thomas S Weiss, Madeleine Lupke, Sara Ibrahim, Christa Buechler, Julia Lorenz, Petra Ruemmele, Ute Hofmann, Michael Melter, Rania Dayoub
Nonalcoholic fatty liver disease (NAFLD) covers a spectrum from simple steatosis to nonalcoholic steatohepatitis (NASH) and cirrhosis. Free fatty acids (FFA) induce steatosis and lipo-toxicity and correlate with severity of NAFLD. In this study we aimed to investigate the role of exogenous and endogenous ALR (augmenter of liver regeneration) for FFA induced ER (endoplasmatic reticulum) -stress and lipoapoptosis. Primary human hepatocytes or hepatoma cells either treated with recombinant human ALR (rhALR, 15kDa) or expressing short form ALR (sfALR, 15kDa) were incubated with palmitic acid (PA) and analyzed for lipo-toxicity, -apoptosis, activation of ER-stress response pathways, triacylglycerides (TAG), mRNA and protein expression of lipid metabolizing genes...
2017: PloS One
https://www.readbyqxmd.com/read/28876383/correlations-of-condition-factor-and-gonadosomatic-hepatosomatic-and-lipo-somatic-relations-of-leptodactylus-macrosternum-anura-leptodactylidae-in-the-brazilian-semi-arid
#20
Marcio F Chaves, Fernanda C M A Tenório, Igor L V L Santos, Clovis J C L, Valeria W Texeira, Geraldo J B Moura, Álvaro A C Texeira
The objective of this study was to assess variations of the condition factor (K1) in relation to the gonadosomatic- RGS and energy reserves (hepatosomatic - RWL and liposomatic - RFB relations) of Leptodactylus macrosternum and their relationship to climate variation in the Northeast of Brazil, Caatinga area, state of Paraiba. The animals were captured fortnightly through active collecting, between January and December 2013. Significant differences were observed in the monthly variations of K1, RGS and RFB indices in male and female L...
July 2017: Anais da Academia Brasileira de Ciências
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