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https://www.readbyqxmd.com/read/28633618/specialized-consultations-in-a-hospital-based-referral-center-for-patients-suspected-of-having-limb-lymphedema-impact-on-diagnosis
#1
Stéphane Vignes, Florence Vidal, Maria Arrault
Lymphedema, a chronic debilitating disease, is not always easily diagnosed. A total of 254 new patients ((217 women, 37 men), median (Q1-Q3) age 61 (46-72) years) were referred for suspected limb lymphedema to an exclusively lymphedema-dedicated department for a first consultation (January - March 2015) were included; among 118 with upper limb involvement, 100 (84.7%) were diagnosed with post-breast cancer therapy and four with primary lymphedemas; among 136 with lower limb involvement, 31 (22.8%) were diagnosed with primary lymphedemas and 35 (25...
June 1, 2017: Vascular Medicine
https://www.readbyqxmd.com/read/28618644/intrinsic-flow-structure-and-multifractality-in-two-dimensional-bacterial-turbulence
#2
Lipo Wang, Yongxiang Huang
The active interaction between the bacteria and fluid generates turbulent structures even at zero Reynolds number. The velocity of such a flow obtained experimentally has been quantitatively investigated based on streamline segment analysis. There is a clear transition at about 16 times the organism body length separating two different scale regimes, which may be attributed to the different influence of the viscous effect. Surprisingly the scaling extracted from the streamline segment indicates the existence of scale similarity even at the zero Reynolds number limit...
May 2017: Physical Review. E
https://www.readbyqxmd.com/read/28605896/liposome-coated-persistent-luminescence-nanoparticles-as-luminescence-trackable-drug-carrier-for-chemotherapy
#3
Li-Jian Chen, Cheng-Xiong Yang, Xiu-Ping Yan
Near-infrared persistent luminescence nanoparticles (NIR-PLNPs) are promising imaging agents due to deep tissue penetration, high signal-to-noise ratio, and repeatedly charging ability. Here, we report liposome-coated NIR-PLNPs (Lipo-PLNPs) as a novel persistent luminescence imaging guided drug carrier for chemotherapy. The Lipo-PLNP nanocomposite shows the advantages of superior persistent luminescence and high drug loading efficiency and enables autofluorescence-free and long-term tracking of drug delivery carriers with remarkable therapeutic effect...
June 15, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28596839/structure-specific-effects-of-lipidated-oxytocin-analogs-on-intracellular-calcium-levels-parental-behavior-and-oxytocin-concentrations-in-the-plasma-and-cerebrospinal-fluid-in-mice
#4
Stanislav M Cherepanov, Shigeru Yokoyama, Akira Mizuno, Wataru Ichinose, Olga Lopatina, Anna A Shabalova, Alla B Salmina, Yasuhiko Yamamoto, Hiroshi Okamoto, Satoshi Shuto, Haruhiro Higashida
Oxytocin (OT) is a neuroendocrine nonapeptide that plays an important role in social memory and behavior. Nasal administration of OT has been shown to improve trust in healthy humans and social interaction in autistic subjects in some clinical trials. As a central nervous system (CNS) drug, however, OT has two unfavorable characteristics: OT is short-acting and shows poor permeability across the blood-brain barrier, because it exists in charged form in the plasma and has short half-life. To overcome these drawbacks, an analog with long-lasting effects is required...
February 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28585309/a-high-performance-li-o2-battery-with-a-strongly-solvating-hexamethylphosphoramide-electrolyte-and-a-lipon-protected-lithium-anode
#5
Bin Zhou, Limin Guo, Yantao Zhang, Jiawei Wang, Lipo Ma, Wen-Hua Zhang, Zhengwen Fu, Zhangquan Peng
The aprotic Li-O2 battery has attracted a great deal of interest because theoretically it can store more energy than today's Li-ion batteries. However, current Li-O2 batteries suffer from passivation/clogging of the cathode by discharged Li2 O2 , high charging voltage for its subsequent oxidation, and accumulation of side reaction products (particularly Li2 CO3 and LiOH) upon cycling. Here, an advanced Li-O2 battery with a hexamethylphosphoramide (HMPA) electrolyte is reported that can dissolve Li2 O2 , Li2 CO3 , and LiOH up to 0...
June 6, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28575852/increased-transcriptional-and-metabolic-capacity-for-lipid-metabolism-in-the-peripheral-zone-of-the-prostate-may-underpin-its-increased-susceptibility-to-cancer
#6
Omar Al Kadhi, Maria H Traka, Antonietta Melchini, Perla Troncoso-Rey, Wiktor Jurkowski, Marianne Defernez, Purnima Pachori, Robert D Mills, Richard Y Ball, Richard F Mithen
The human prostate gland comprises three distinct anatomical glandular zones, namely the peripheral, central and transitional zones. Although prostate cancer can arise throughout the prostate, it is more frequent in the peripheral zone. In contrast, hyperplasia occurs most frequently in the transitional zone. In this paper, we test the hypothesis that peripheral and transitional zones have distinct metabolic adaptations that may underlie their different inherent predispositions to cancer and hyperplasia. In order to do this, we undertook RNA sequencing and high-throughput metabolic analyses of non-cancerous tissue from the peripheral and transitional zones of patients undergoing prostatectomy...
May 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28558948/ultrasonic-assisted-incorporation-of-nano-encapsulated-omega-3-fatty-acids-to-enhance-the-fatty-acid-profile-of-pork-meat
#7
K Shikha Ojha, Camila A Perussello, Carlos Álvarez García, Joseph P Kerry, Daniel Pando, Brijesh K Tiwari
In this study, ultrasound was employed to enhance the diffusion of microencapsulated fatty acids into pork meat. Nanovesicles of fish oil composed of 42% EPA (eicosapentanoic acid) and 16% DHA (docosahexanoic acid) were prepared using two different commercial Pronanosome preparations (Lipo-N and Lipo-CAT; which yield cationic and non-cationic nanovesicles, respectively). The thin film hydration (TFH) methodology was employed for encapsulation. Pork meat (Musculus semitendinosus) was submerged in the nanovesicles suspension and subjected to ultrasound (US) treatment at 25kHz for either 30 or 60min...
May 5, 2017: Meat Science
https://www.readbyqxmd.com/read/28545855/-a-complex-case-of-diabetes-due-to-lmna-mutation
#8
C Ambonville, M-A Bouldouyre, P Laforêt, P Richard, O Benveniste, C Vigouroux
INTRODUCTION: Laminopathies (diseases related to A/C mutations of lamines) are rare genetic diseases with an extensive phenotypic spectrum, including lipodystrophic syndromes-characterized by a selective loss of adipose tissue-of which the partial Dunnigan family type is the most frequent. CASE REPORT: We report on a 55-year-old woman with diabetes and long-term disabling myalgia. Her cushingoid morphotype, associated with cutaneous lipo-atrophy and muscle hypertrophy in addition to a genetic heritage, led us to the diagnosis of complex partial familial lipodystrophy heterozygous LMNA_c...
May 22, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/28534572/sensing-of-fluoride-ions-in-aqueous-media-using-a-luminescent-coordination-polymer-and-liposome-composite
#9
Masayuki Honjo, Tomomi Koshiyama, Yumi Fukunaga, Yasuhiro Tsuji, Motoki Tanaka, Masaaki Ohba
The synthesis of a luminescent coordination polymer (Tb-BTC) within the confined environment of a liposome allowed for the anisotropic growth of nanosized Tb-BTC crystals. Consequently, the resulting composite Tb-BTC@Lipo exhibited a higher fluorescence sensitivity to fluoride anions in aqueous media compared to the independent Tb-BTC in bulk.
June 6, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28520810/long-chain-saturated-and-unsaturated-fatty-acids-exert-opposing-effects-on-viability-and-function-of-glp-1-producing-cells-mechanisms-of-lipotoxicity
#10
Ketan Thombare, Stelia Ntika, Xuan Wang, Camilla Krizhanovskii
BACKGROUND AND AIM: Fatty acids acutely stimulate GLP-1 secretion from L-cells in vivo. However, a high fat diet has been shown to reduce the density of L-cells in the mouse intestine and a positive correlation has been indicated between L-cell number and GLP-1 secretion. Thus, the mechanism of fatty acid-stimulated GLP-1 secretion, potential effects of long-term exposure to elevated levels of different fatty acid species, and underlying mechanisms are not fully understood. In the present study, we sought to determine how long-term exposure to saturated (16:0) and unsaturated (18:1) fatty acids, by direct effects on GLP-1-producing cells, alter function and viability, and the underlying mechanisms...
2017: PloS One
https://www.readbyqxmd.com/read/28484000/h2o2-responsive-liposomal-nanoprobe-for-photoacoustic-inflammation-imaging-and-tumor-theranostics-via-in-vivo-chromogenic-assay
#11
Qian Chen, Chao Liang, Xiaoqi Sun, Jiawen Chen, Zhijuan Yang, He Zhao, Liangzhu Feng, Zhuang Liu
Abnormal H2O2 levels are closely related to many diseases, including inflammation and cancers. Herein, we simultaneously load HRP and its substrate, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), into liposomal nanoparticles, obtaining a Lipo@HRP&ABTS optical nanoprobe for in vivo H2O2-responsive chromogenic assay with great specificity and sensitivity. In the presence of H2O2, colorless ABTS would be converted by HRP into the oxidized form with strong near-infrared (NIR) absorbance, enabling photoacoustic detection of H2O2 down to submicromolar concentrations...
May 23, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28476616/preparation-of-liposomes-containing-small-gold-nanoparticles-using-electrostatic-interactions
#12
Gennaro A Dichello, Takahiro Fukuda, Toru Maekawa, Raymond L D Whitby, Sergey V Mikhalovsky, Mohammed Alavijeh, Ananth S Pannala, Dipak K Sarker
The development of liposome-nanoparticle colloid systems offers a versatile approach towards the manufacture of multifunctional therapeutic platforms. A strategy to encapsulate small metallic nanoparticles (<4nm) within multilamellar vesicles, effected by exploiting electrostatic interactions was investigated. Two liposome-gold nanoparticle (lipo-GNP) systems were prepared by the reverse-phase evaporation method employing cationic or anionic surface functionalised particles in combination with oppositely charged lipid compositions with subsequent post-formulation PEGylation...
May 3, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28472842/diterpene-lipo-alkaloids-with-selective-activities-on-cardiac-k-channels
#13
Tivadar Kiss, Botond Borcsa, Péter Orvos, László Tálosi, Judit Hohmann, Dezső Csupor
Aconitum diterpene alkaloids are known for their remarkable toxicity, which is due to their effect on ion channels. Activation of voltage-gated Na(+) channels is the major cause of their cardiotoxicity, however, influence on K(+) channels may also play a role in the overall effect.Here we report the synthesis of a series of lipo-alkaloids, including four new compounds, based on the 14-benzoylaconine structure, which is the core of a vast number of diterpene alkaloids naturally occurring in Aconitum species...
May 4, 2017: Planta Medica
https://www.readbyqxmd.com/read/28460165/development-of-a-rapidly-dissolvable-oral-pediatric-formulation-for-mefloquine-using-liposomes
#14
Wei-Lun Tang, Wei-Hsin Tang, Weihsu Claire Chen, Charles Diako, Carolyn F Ross, Shyh-Dar Li
Mefloquine (Mef), a poorly soluble and highly bitter drug, has been used for malaria prophylaxis and treatment. The dosage form for Mef is mostly available as adult tablets, and thus children under the age of 5 suffer from poor medication adherence. We have developed a stable, rapidly dissolvable, and palatable pediatric formulation for Mef using liposomes composed of 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) and cholesterol with a mean diameter of ∼110 nm. Mef was actively loaded into the liposomes via an ammonium sulfate gradient using the solvent-assisted loading technology (SALT) developed in our lab...
May 9, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28450938/isolation-culture-and-identification-of-human-adipose-derived-stem-cells
#15
Jian-Mei Wang, Yan Gu, Cai-Jun Pan, Li-Rong Yin
The aim of the present study was to improve methods for the isolation and identification of adipose-derived stem cells (ASCs). Human subcutaneous adipose tissue was collected during liposuction surgery, without ultrasound-assisted liposuction and other assisted techniques, and digested with 0.075% collagenase I. First (P1) and second (P2) passage ASCs were applied to the subsequent experiments. ASCs were observed under a microscope, the growth curves of the cells were assessed using a cell counting kit-8 assay and the membrane expression of cell surface antigens, including cluster of differentiation (CD)44, CD105 and CD45, were detected by flow cytometry...
March 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28435448/inhibition-of-platelet-function-using-liposomal-nanoparticles-blocks-tumor-metastasis
#16
Yinlong Zhang, Jingyan Wei, Shaoli Liu, Jing Wang, Xuexiang Han, Hao Qin, Jiayan Lang, Keman Cheng, Yiye Li, Yingqiu Qi, Greg J Anderson, Saraswati Sukumar, Suping Li, Guangjun Nie
Extensive evidence has shown that platelets support tumor metastatic progression by inducing epithelial-mesenchymal transition of cancer cells and by shielding circulating tumor cells from immune-mediated elimination. Therefore, blocking platelet function represents a potential new avenue for therapy focused on eliminating metastasis. Here we show that liposomal nanoparticles bearing the tumor-homing pentapeptide CREKA (Cys-Arg-Glu-Lys-Ala) can deliver a platelet inhibitor, ticagrelor, into tumor tissues to specifically inhibit tumor-associated platelets...
2017: Theranostics
https://www.readbyqxmd.com/read/28418672/a-liposome-encapsulated-ruthenium-polypyridine-complex-as-a-theranostic-platform-for-triple-negative-breast-cancer
#17
Jianliang Shen, Han-Cheon Kim, Joy Wolfram, Chaofeng Mu, Wei Zhang, Haoran Liu, Yan Xie, Junhua Mai, Hang Zhang, Zhi Li, Maria Guevara, Zong-Wan Mao, Haifa Shen
Ruthenium coordination complexes have the potential to serve as novel theranostic agents for cancer. However, a major limitation in their clinical implementation is effective tumor accumulation. In this study, we have developed a liposome-based theranostic nanodelivery system for [Ru(phen)2dppz](ClO4)2 (Lipo-Ru). This ruthenium polypyridine complex emits a strong fluorescent signal when incorporated in the hydrophobic lipid bilayer of the delivery vehicle or in the DNA helix, enabling visualization of the therapeutic agent in tumor tissues...
April 21, 2017: Nano Letters
https://www.readbyqxmd.com/read/28417106/comparative-analysis-of-the-combined-therapeutic-effects-of-lipoprostaglandin-e1-on-sudden-idiopathic-sensorineural-hearing-loss
#18
Haeng Seon Shim, Joon Soo Kim, Myung Gu Kim
BACKGROUND AND OBJECTIVES: Viral and vascular disorders are considered to be a major cause of idiopathic sudden sensorineural hearing loss (ISSNHL). Lipoprostaglandin E1 (lipo-PGE1) has vasodilating activity and has been used to treat ISSNHL. The purpose of this study was to determine the specific therapeutic effects of lipo-PGE1 and compare them to other treatment modalities for ISSNHL. SUBJECTS AND METHODS: The study group had 1,052 patients diagnosed with ISSNHL...
April 2017: Journal of Audiology & Otology
https://www.readbyqxmd.com/read/28406829/the-lipo-bodylift-a-new-circumferential-body-contouring-technique-useful-after-bariatric-surgery
#19
Nicolas Bertheuil, Benoit Chaput, Antoine De Runz, Paul Girard, Raphael Carloni, Eric Watier
No abstract text is available yet for this article.
April 3, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28406826/the-lipo-body-lift-a-new-circumferential-body-contouring-technique-useful-after-bariatric-surgery
#20
Morgane Atanasiu, Audrey Patoué
No abstract text is available yet for this article.
April 3, 2017: Plastic and Reconstructive Surgery
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