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painful diabetic neuropathy dorsal root ganglion

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https://www.readbyqxmd.com/read/29599806/wentong-huoxue-cream-can-inhibit-the-reduction-of-the-pain-related-molecule-plc-%C3%AE-3-in-the-dorsal-root-ganglion-of-a-rat-model-of-diabetic-peripheral-neuropathy
#1
Chengcheng Feng, Lijuan Xu, Shiyun Guo, Qian Chen, Yuguo Shen, Deng Zang, Li Ma
WenTong HuoXue Cream (WTHX-Cream) has been shown to effectively alleviate clinical symptoms of diabetic peripheral neuropathy (DPN). This study investigated the gene and protein expression of the pain-related molecule PLC- β 3 in the dorsal root ganglion (DRG) of DPN rats. 88 specific pathogen-free male Wistar rats were randomly divided into placebo (10 rats) and DPN model (78 rats) groups, and the 78 model rats were used to establish the DPN model by intraperitoneal injection of streptozotocin and were then fed a high-fat diet for 8 weeks...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29575331/retrospective-case-series-on-the-treatment-of-painful-diabetic-peripheral-neuropathy-with-dorsal-root-ganglion-stimulation
#2
Sam Eldabe, Anthony Espinet, Anders Wahlstedt, Porhan Kang, Liong Liem, Nikunj K Patel, Jan Vesper, Alicia Kimber, William Cusack, Jeffery Kramer
BACKGROUND: The dorsal root ganglion (DRG) has been identified as an important neural structure in the development and maintenance of chronic pain. We present a retrospective case series of patients with refractory painful diabetic peripheral neuropathy (PDPN) that underwent electrical stimulation of the DRG and report on changes in their overall perceived pain and complication rates. METHODS: Ten diabetic males (mean age 65.2 [SD 8.8] years) with painful symptoms of the lower limbs were enrolled and trialed with up to four quadripolar percutaneous DRG stimulation leads between L2 and L5 spinal levels...
March 25, 2018: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29533926/reducing-cxcr4-mediated-nociceptor-hyperexcitability-reverses-painful-diabetic-neuropathy
#3
Nirupa D Jayaraj, Bula J Bhattacharyya, Abdelhak A Belmadani, Dongjun Ren, Craig A Rathwell, Sandra Hackelberg, Brittany E Hopkins, Herschel R Gupta, Richard J Miller, Daniela M Menichella
Painful diabetic neuropathy (PDN) is an intractable complication of diabetes that affects 25% of patients. PDN is characterized by neuropathic pain and small-fiber degeneration, accompanied by dorsal root ganglion (DRG) nociceptor hyperexcitability and loss of their axons within the skin. The molecular mechanisms underlying DRG nociceptor hyperexcitability and small-fiber degeneration in PDN are unknown. We hypothesize that chemokine CXCL12/CXCR4 signaling is central to this mechanism, as we have shown that CXCL12/CXCR4 signaling is necessary for the development of mechanical allodynia, a pain hypersensitivity behavior common in PDN...
March 13, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29474476/rage-dependent-potentiation-of-trpv1-currents-in-sensory-neurons-exposed-to-high-glucose
#4
Doris Lam, Zeinab Momeni, Michael Theaker, Santosh Jagadeeshan, Yasuhiko Yamamoto, Juan P Ianowski, Verónica A Campanucci
Diabetes mellitus is associated with sensory abnormalities, including exacerbated responses to painful (hyperalgesia) or non-painful (allodynia) stimuli. These abnormalities are symptoms of diabetic peripheral neuropathy (DPN), which is the most common complication that affects approximately 50% of diabetic patients. Yet, the underlying mechanisms linking hyperglycemia and symptoms of DPN remain poorly understood. The transient receptor potential vanilloid 1 (TRPV1) channel plays a central role in such sensory abnormalities and shows elevated expression levels in animal models of diabetes...
2018: PloS One
https://www.readbyqxmd.com/read/29421543/sigma-1-receptor-mediated-hmgb1-expression-in-spinal-cord-is-involved-in-the-development-of-diabetic-neuropathic-pain
#5
Xiaolei Wang, Chang Feng, Yong Qiao, Xin Zhao
No study has been conducted to examine the interactions of sigma-1 receptor (Sigma-1R) and high mobility group box 1 protein (HMGB1) in the development of diabetic peripheral neuropathy. Thus, we examined the effects of streptozotocin (STZ) treatment on expression of HMGB1 in subcellular levels in the dorsal root ganglion (DRG) in both wild-type and Sigma-1R-/- mice and evaluated the effects of repeated intrathecal administrations of selective Sigma-1R antagonists BD1047, agonist PRE-084, or HMGB1 inhibitor glycyrrhizin on peripheral neuropathy in wild-type mice...
February 5, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29388177/tanshinone-iia-improves-painful-diabetic-neuropathy-by-suppressing-the-expression-and-activity-of-voltage-gated-sodium-channel-in-rat-dorsal-root-ganglia
#6
Ao Ri-Ge-le, Zhuang-Li Guo, Qi Wang, Bao-Jian Zhang, Da-Wei Kong, Wen-Qiang Yang, Yan-Bing Yu, Li Zhang
Painful diabetic neuropathy (PDN) is one of the intractable complications of diabetes mellitus, which manifest as exaggerated pain perception. Previous studies showed that Tanshinone IIA (TIIA), one of the major bioactive extracts of Salvia miltiorrhiza Bunge, have obvious analgesic effect on different types of pain process, and the underlying analgesic mechanisms are not fully understood. The present study combined the behavioral, electrophysiological and biochemical methods to elucidate the analgesic mechanism of TIIA, using streptozotocin (STZ)-induced PDN rat models...
January 31, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29097792/interactions-of-notch1-and-tlr4-signaling-pathways-in-drg-neurons-of-in-vivo-and-in-vitro-models-of-diabetic-neuropathy
#7
Tianhua Chen, Hao Li, Yiting Yin, Yuanpin Zhang, Zhen Liu, Huaxiang Liu
Understanding the interactions between Notch1 and toll-like receptor 4 (TLR4) signaling pathways in the development of diabetic peripheral neuropathy may lead to interpretation of the mechanisms and novel approaches for preventing diabetic neuropathic pain. In the present study, the interactions between Notch1 and TLR4 signaling pathways were investigated by using dorsal root ganglion (DRG) from diabetic neuropathic pain rats and cultured DRG neurons under high glucose challenge. The results showed that high glucose induced not only Notch1 mRNA, HES1 mRNA, and TLR4 mRNA expression, but also Notch1 intracellular domain (NICD1) and TLR4 protein expression in DRG neurons...
November 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29025860/negative-regulation-of-trpa1-by-ampk-in-primary-sensory-neurons-as-a-potential-mechanism-of-painful-diabetic-neuropathy
#8
Shenglan Wang, Kimiko Kobayashi, Yoko Kogure, Hiroki Yamanaka, Satoshi Yamamoto, Hideshi Yagi, Koichi Noguchi, Yi Dai
AMPK is a widely expressed intracellular energy sensor that monitors and modulates energy expenditure. Transient receptor potential ankyrin 1 (TRPA1) channel is a widely recognized chemical and thermal sensor that plays vital roles in pain transduction. In this study, we discovered a functional link between AMPK and TRPA1 in dorsal root ganglion (DRG) neurons, in which AMPK activation rapidly resulted in downregulation of membrane-associated TRPA1 and its channel activity within minutes. Treatment with two AMPK activators, metformin or AICAR, inhibited TRPA1 activity in DRG neurons by decreasing the amount of membrane-associated TRPA1...
January 2018: Diabetes
https://www.readbyqxmd.com/read/28726540/mechanisms-of-the-analgesic-effect-of-calcitonin-on-chronic-pain-by-alteration-of-receptor-or-channel-expression
#9
Akitoshi Ito, Megumu Yoshimura
The polypeptide hormone calcitonin is well known clinically for its ability to relieve osteoporotic back pain and neuropathic pain such as spinal canal stenosis, diabetic neuropathy, chemotherapy-induced neuropathy, and complex regional pain syndrome. Because the analgesic effects of calcitonin have a broad range, the underlying mechanisms of pain relief by calcitonin are largely unknown. However, recent studies using several types of chronic pain models combined with various methods have been gradually clarifying the mechanism...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28535564/the-different-dynamic-changes-of-nerve-growth-factor-in-the-dorsal-horn-and-dorsal-root-ganglion-leads-to-hyperalgesia-and-allodynia-in-diabetic-neuropathic-pain
#10
Zhifeng Gao, Yi Feng, Hui Ju
BACKGROUND: Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes and more than half of the patients with DPN have self-reported symptoms referring to painful diabetic neuropathy (PDN). Nerve growth factor (NGF) is a key factor for the nervous system, but the role of it in the neuropathic pain of diabetic patients is unclear. OBJECTIVE: This study aimed to investigate the relationship between the dynamic expression of NGF in dorsal horn and dorsal root ganglion (DRG) of diabetic rats and hyperalgesia and allodynia in diabetic neuropathic pain...
May 2017: Pain Physician
https://www.readbyqxmd.com/read/28373151/neuroprotective-effect-of-cerium-oxide-nanoparticles-in-a-rat-model-of-experimental-diabetic-neuropathy
#11
Rezvan Najafi, Asieh Hosseini, Habib Ghaznavi, Saeed Mehrzadi, Ali M Sharifi
OBJECTIVE: Neuropathies are a nerve disorders that caused by diabetes. Neuropathy affects over 50% of diabetic patients. High blood glucose and their toxic byproducts are the main causes for nerve dysfunction. In the present study, we examined the neroprotective effects of cerium oxide (CeO2) nanoparticles in diabetic rats. METHOD: Rats divided into four groups: control group, diabetic group, the diabetic group treated with CeO2 nanoparticle at a dose of 65mg/kg and diabetic group received CeO2 nanoparticle at a dose of 85mg/kg...
March 31, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28350939/the-advancing-role-of-neuromodulation-for-the-management-of-chronic-treatment-refractory-pain
#12
REVIEW
Mohammed F Shamji, Cecile De Vos, Ashwini Sharan
Neuropathic pain is a common cause of disability and health care utilization. While judicious pharmacotherapy and management of comorbid psychological distress can provide for improved quality of life, some patients with treatment-refractory disease require more invasive therapies. Spinal cord stimulation can provide for improvement in pain and decrease in medication utilization, with level 1 evidence supporting its use across various pain etiologies including persistent postoperative neuropathic pain, complex regional pain syndrome, chronic inoperable limb ischemia, treatment refractory angina, and painful diabetic neuropathy...
March 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/27857760/galanin-and-its-receptor-system-promote-the-repair-of-injured-sciatic-nerves-in-diabetic-rats
#13
Xiao-Feng Xu, Dan-Dan Zhang, Jin-Chi Liao, Li Xiao, Qing Wang, Wei Qiu
Various studies have reported that galanin can promote axonal regeneration of dorsal root ganglion neurons in vitro and inhibit neuropathic pain. However, little is known about its effects on diabetic peripheral neuropathy, and in vivo experimental data are lacking. We hypothesized that repeated applications of exogenous galanin over an extended time frame may also repair nerve damage in diabetic peripheral neuropathy, and relieve pain in vivo. We found that neuropathic pain occurred in streptozotocin-induced diabetic rats and was more severe after sciatic nerve pinch injury at 14 and 28 days than in diabetic sham-operated rats...
September 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27608006/roles-of-voltage-gated-tetrodotoxin-sensitive-sodium-channels-nav1-3-and-nav1-7-in-diabetes-and-painful-diabetic-neuropathy
#14
REVIEW
Linlin Yang, Quanmin Li, Xinming Liu, Shiguang Liu
Diabetes mellitus (DM) is a common chronic medical problem worldwide; one of its complications is painful peripheral neuropathy, which can substantially erode quality of life and increase the cost of management. Despite its clinical importance, the pathogenesis of painful diabetic neuropathy (PDN) is complex and incompletely understood. Voltage-gated sodium channels (VGSCs) link many physiological processes to electrical activity by controlling action potentials in all types of excitable cells. Two isoforms of VGSCs, NaV1...
September 5, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/26946108/intrathecal-administration-of-rapamycin-inhibits-the-phosphorylation-of-drg-nav1-8-and-attenuates-stz-induced-painful-diabetic-neuropathy-in-rats
#15
Wan-You He, Bin Zhang, Qing-Ming Xiong, Cheng-Xiang Yang, Wei-Cheng Zhao, Jian He, Jun Zhou, Han-Bing Wang
The mammalian target of rapamycin (mTOR) is a key regulator of mRNA translation and protein synthesis, and it is specifically inhibited by rapamycin. In chronic pain conditions, mTOR-mediated local protein synthesis is crucial for neuronal hyperexcitability and synaptic plasticity. The tetrodotoxin-resistant (TTX-R) sodium channel Nav1.8 plays a major role in action potential initiation and propagation and cellular excitability in DRG (dorsal root ganglion) neurons. In this study, we investigated if mTOR modulates the phosphorylation of Nav1...
April 21, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/26802537/viral-vector-mediated-continuous-expression-of-interleukin-10-in-drg-alleviates-pain-in-type-1-diabetic-animals
#16
Vikram Thakur, Mayra Gonzalez, Kristen Pennington, Munmun Chattopadhyay
Painful diabetic neuropathy is a common and difficult to treat complication of diabetes. A growing body of evidence implicates the role of inflammatory mediators in the damage to the peripheral axons and in the pathogenesis of neuropathic pain. Increased expression of pro-inflammatory cytokines such as interleukin (IL)-1β and tumor necrosis factor (TNF)-α in the peripheral nervous system suggests the possibility of change in pain perception in diabetes. In this study we investigated that continuous delivery of IL10 in the nerve fibers achieved by HSV vector mediated transduction of dorsal root ganglion (DRG) in animals with Type 1 diabetes, blocks the nociceptive and stress responses in the DRG neurons by reducing IL1β expression along with inhibition of phosphorylation of p38 MAPK (mitogen-activated protein kinase) and protein kinase C (PKC)...
April 2016: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/26629685/glycolytic-metabolite-methylglyoxal-inhibits-cold-and-menthol-activation-of-the-transient-receptor-potential-melastatin-type-8-channel
#17
A C Ciobanu, T Selescu, I Gasler, L Soltuzu, A Babes
Methylglyoxal (MG) is a reactive dicarbonyl compound involved in protein modifications linked to diabetes mellitus. The plasma level of MG is elevated in diabetic patients, particularly those with painful diabetic neuropathy. Diabetic neuropathy is often associated with spontaneous pain and altered thermal perception. This study assesses effects of MG on TRPM8, an ion channel involved in innocuous cold sensing and cold allodynia and also in cold-mediated analgesia. Acute treatment with MG inhibited the activation of recombinant rat and human transient receptor potential melastatin type 8 (TRPM8) by cold and chemical agonists...
March 2016: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/26609114/%C3%AE-dendrotoxin-sensitive-kv1-channels-contribute-to-conduction-failure-of-polymodal-nociceptive-c-fibers-from-rat-coccygeal-nerve
#18
Xiu-Chao Wang, Shan Wang, Ming Zhang, Fang Gao, Chun Yin, Hao Li, Ying Zhang, San-Jue Hu, Jian-Hong Duan
It is known that some patients with diabetic neuropathy are usually accompanied by abnormal painful sensations. Evidence has accumulated that diabetic neuropathic pain is associated with the hyperexcitability of peripheral nociceptors. Previously, we demonstrated that reduced conduction failure of polymodal nociceptive C-fibers and enhanced voltage-dependent sodium currents of small dorsal root ganglion (DRG) neurons contribute to diabetic hyperalgesia. To further investigate whether and how potassium channels are involved in the conduction failure, α-dendrotoxin (α-DTX), a selective blocker of the low-threshold sustained Kv1 channel, was chosen to examine its functional capability in modulating the conduction properties of polymodal nociceptive C-fibers and the excitability of sensory neurons...
February 1, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/26520392/antinociceptive-effects-of-fisetin-against-diabetic-neuropathic-pain-in-mice-engagement-of-antioxidant-mechanisms-and-spinal-gabaa-receptors
#19
Xin Zhao, Xin-Lin Li, Xin Liu, Chuang Wang, Dong-Sheng Zhou, Qing Ma, Wen-Hua Zhou, Zhen-Yu Hu
Peripheral painful neuropathy is one of the most common complications in diabetes and necessitates improved treatment. Fisetin, a naturally occurring flavonoid, has been reported to exert antidepressant-like effect in previous studies. As antidepressant drugs are employed clinically to treat neuropathic pain, this work aimed to investigate whether fisetin possess beneficial effect on diabetic neuropathic pain and explore the mechanism(s). We subjected mice to diabetes by a single intraperitoneal (i.p.) injection of streptozotocin (200mg/kg), and von Frey test or Hargreaves test was used to assess mechanical allodynia or thermal hyperalgesia, respectively...
December 2015: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/26479925/inhibition-of-mechanical-allodynia-in-neuropathic-pain-by-tlr5-mediated-a-fiber-blockade
#20
Zhen-Zhong Xu, Yong Ho Kim, Sangsu Bang, Yi Zhang, Temugin Berta, Fan Wang, Seog Bae Oh, Ru-Rong Ji
Mechanical allodynia, induced by normally innocuous low-threshold mechanical stimulation, represents a cardinal feature of neuropathic pain. Blockade or ablation of high-threshold, small-diameter unmyelinated group C nerve fibers (C-fibers) has limited effects on mechanical allodynia. Although large, myelinated group A fibers, in particular Aβ-fibers, have previously been implicated in mechanical allodynia, an A-fiber-selective pharmacological blocker is still lacking. Here we report a new method for targeted silencing of A-fibers in neuropathic pain...
November 2015: Nature Medicine
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