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https://www.readbyqxmd.com/read/27932981/proton-pump-inhibitors-display-antitumor-effects-in-barrett-s-adenocarcinoma-cells
#1
Eduardo Chueca, Nadezda Apostolova, Juan V Esplugues, María A García-González, Ángel Lanas, Elena Piazuelo
Recent evidence has reported that proton pump inhibitors (PPIs) can exert antineoplastic effects through the disruption of pH homeostasis by inhibiting vacuolar ATPase (H(+)-VATPase), a proton pump overexpressed in several tumor cells, but this aspect has not been deeply investigated in EAC yet. In the present study, the expression of H(+)-VATPase was assessed through the metaplasia-dysplasia-adenocarcinoma sequence in Barrett's esophagus (BE) and the antineoplastic effects of PPIs and cellular mechanisms involved were evaluated in vitro...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27931632/complications-of-therapeutic-gastroscopy-colonoscopy-other-than-resection
#2
REVIEW
Zaheer Nabi
Gastrointestinal (GI) endoscopy is profoundly utilized for diagnostic and therapeutic purposes. The therapeutic potential of GI endoscopy has amplified many folds with the evolution of novel techniques as well as equipments. However, with the augmentation of therapeutic endoscopy, the extent, likelihood and severity of adverse events have increased as well. The attendant risks and adverse events with therapeutic endoscopy are many folds that of diagnostic endoscopy. Besides endoscopic resection, therapeutic endoscopy is widely utilized for hemostasis in GI bleeds, dilatation of stenosis, enteral stenting, foreign body removal, ablation of Barrett's esophagus etc...
October 2016: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/27928980/inside-doctor-livingstone-a-scottish-icon-s-encounter-with-tropical-disease
#3
Michael P Barrett, Federica Giordani
Dr David Livingstone died on May 1st 1873. He was 60 years old and had spent much of the previous 30 years walking across large stretches of Southern Africa, exploring the terrain he hoped could provide new environments in which Europeans and Africans could cohabit on equal terms and bring prosperity to a part of the world he saw ravaged by the slave trade. Just days before he died, he wrote in his journal about the permanent stream of blood that he was emitting related to haemorrhoids and the acute intestinal pain that had left him incapable of walking...
December 8, 2016: Parasitology
https://www.readbyqxmd.com/read/27928070/novel-response-patterns-during-repeated-presentation-of-affective-and-neutral-stimuli
#4
Ajay B Satpute, Lydia Hanington, Lisa F Barrett
Repeated stimulus presentations are commonly used in social and affective neuroimaging tasks, but much remains to be known about how the brain processes such repetitions. Using functional magnetic resonance imaging, we found three groups of brain regions with distinct response patterns during repeated presentations of natural scene images. One group consisted of several limbic, paralimbic, frontoparietal and medial prefrontal areas and showed a habituation-like response across pleasant, unpleasant, and neutral image categories...
December 2016: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/27927666/epigenetic-biomarkers-in-progression-from-non-dysplastic-barrett-s-oesophagus-to-oesophageal-adenocarcinoma-a-systematic-review-protocol
#5
T Nieto, C L Tomlinson, J Dretzke, S Bayliss, M Dilworth, A D Beggs, O Tucker
INTRODUCTION: Barrett's oesophagus (BO), a metaplastic condition affecting the lower oesophagus due to long-standing gastro-oesophageal reflux and chronic inflammation, is a precursor lesion for oesophageal adenocarcinoma (OADC). There is no clinical test to predict which patients with BO will progress to OADC. The British Society of Gastroenterology recommends endoscopic surveillance of patients with BO. Epigenetic changes have been well characterised in the neoplastic progression of ulcerative colitis to colonic carcinoma, another gastrointestinal cancer associated with chronic inflammation...
December 7, 2016: BMJ Open
https://www.readbyqxmd.com/read/27927517/management-of-spinal-implants-in-acute-pediatric-surgical-site-infections-a-multicenter-study
#6
Michael P Glotzbecker, Jaime A Gomez, Patricia E Miller, Michael J Troy, David L Skaggs, Michael G Vitale, John M Flynn, Kody K Barrett, Gregory I Pace, Brittany N Atuahene, Daniel J Hedequist
STUDY DESIGN: A retrospective review of patients who underwent posterior spinal fusion (PSF) and returned within 90 days with an acute infection. OBJECTIVES: The study motive is to identify and understand the risk factors associated with failure of retaining spinal implants and failure to treat acute infection. BACKGROUND: The natural history of early surgical site infection (SSI) (less than 3 months) after PSF is not known and removing the implants early after PSF risks pseudarthrosis and deformity progression...
July 2016: Spine Deformity
https://www.readbyqxmd.com/read/27923949/novel-bumped-kinase-inhibitors-are-safe-and-effective-therapeutics-in-the-calf-clinical-model-for-cryptosporidiosis
#7
Deborah A Schaefer, Dana P Betzer, Kylie D Smith, Zachary G Millman, Hannah C Michalski, Sarah E Menchaca, Jennifer A Zambriski, Kayode K Ojo, Matthew A Hulverson, Samuel L M Arnold, Kasey L Rivas, Rama S R Vidadala, Wenlin Huang, Lynn K Barrett, Dustin J Maly, Erkang Fan, Wesley C Van Voorhis, Michael W Riggs
Cryptosporidiosis, caused by the apicomplexan parasite Cryptosporidium parvum, is a diarrheal disease that has produced a large global burden in mortality and morbidity in humans and livestock. There are currently no consistently effective parasite-specific pharmaceuticals available for this disease. Bumped kinase inhibitors (BKIs) specific for parasite calcium-dependent protein kinases (CDPKs) have been shown to reduce infection in several parasites having medical and veterinary importance, including Toxoplasma gondii, Plasmodium falciparum, and C...
December 15, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27922474/embracing-a-nurse-driven-alcohol-withdrawal-protocol-through-quality-improvement
#8
John Barrett, Maria Jansen, April Cooper, Matthew Felbinger, Faith Waters
BACKGROUND: Alcohol withdrawal can lead to severe complications including seizures, delirium tremens, and death if not treated appropriately. Nurses are critical to the safety and outcomes of these patients. OBJECTIVE: The objective of this retrospective study was to determine if nursing education on a community hospital's alcohol withdrawal protocol led to improved nursing compliance. METHODS: This is a quality improvement project involving a two-part retrospective review-an initial needs assessment followed by nursing education and a subsequent posteducation retrospective review...
October 2016: Journal of Addictions Nursing
https://www.readbyqxmd.com/read/27917409/gadolinium-functionalized-peptide-amphiphile-micelles-for-multimodal-imaging-of-atherosclerotic-lesions
#9
Sang Pil Yoo, Federico Pineda, John C Barrett, Christopher Poon, Matthew Tirrell, Eun Ji Chung
The leading causes of morbidity and mortality globally are cardiovascular diseases, and nanomedicine can provide many improvements including disease-specific targeting, early detection, and local delivery of diagnostic agents. To this end, we designed fibrin-binding, peptide amphiphile micelles (PAMs), achieved by incorporating the targeting peptide cysteine-arginine-glutamic acid-lysine-alanine (CREKA), with two types of amphiphilic molecules containing the gadoliniuim (Gd) chelator diethylenetriaminepentaacetic acid (DTPA), DTPA-bis(stearylamide)(Gd), and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[(poly(ethylene glycol) (PEG))-2000]-DTPA(Gd) (DSPE-PEG2000-DTPA(Gd))...
November 30, 2016: ACS Omega
https://www.readbyqxmd.com/read/27917099/radiofrequency-ablation-for-dysplastic-and-nondysplastic-barrett-esophagus
#10
George Triadafilopoulos
No abstract text is available yet for this article.
September 2016: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27916410/meeting-report-who-consultation-on-considerations-for-regulatory-expectations-of-zika-virus-vaccines-for-use-during-an-emergency
#11
K S Vannice, B K Giersing, D C Kaslow, E Griffiths, H Meyer, A Barrett, A P Durbin, D Wood, J Hombach
On 1 February 2016, in the context of the ongoing Zika virus epidemic, the WHO declared that the recently reported clusters of microcephaly and other neurological disorders constituted a Public Health Emergency of International Concern (PHEIC). In response, WHO in collaboration with UNICEF and a working group of independent subject matter experts developed a Zika virus vaccine Target Product Profile (TPP) for use in an emergency, or in a future outbreak scenario. The drafting process of the Zika virus vaccine TPP included the opportunity for public comment, as well as consultation with epidemiologists, flavivirus vaccine subject matter experts, vaccine developers and global regulators to consider the regulatory expectations and potential emergency use pathways for a vaccine with the characteristics described in the TPP...
December 1, 2016: Vaccine
https://www.readbyqxmd.com/read/27914903/cognitive-behavioural-therapy-and-short-term-psychoanalytical-psychotherapy-versus-a-brief-psychosocial-intervention-in-adolescents-with-unipolar-major-depressive-disorder-impact-a-multicentre-pragmatic-observer-blind-randomised-controlled-superiority-trial
#12
Ian M Goodyer, Shirley Reynolds, Barbara Barrett, Sarah Byford, Bernadka Dubicka, Jonathan Hill, Fiona Holland, Raphael Kelvin, Nick Midgley, Chris Roberts, Rob Senior, Mary Target, Barry Widmer, Paul Wilkinson, Peter Fonagy
BACKGROUND: Psychological treatments for adolescents with unipolar major depressive disorder are associated with diagnostic remission within 28 weeks in 65-70% of patients. We aimed to assess the medium-term effects and costs of psychological therapies on maintenance of reduced depression symptoms 12 months after treatment. METHODS: We did this multicentre, pragmatic, observer-blind, randomised controlled superiority trial (IMPACT) at 15 National Health Service child and adolescent mental health service (CAMHS) clinics in three regions in England...
November 30, 2016: Lancet Psychiatry
https://www.readbyqxmd.com/read/27914483/self-reported-testing-and-treatment-histories-among-older-australian-men-and-women-who-may-be-at-risk-of-a-sexually-transmissible-infection
#13
Wendy Heywood, Anthony Lyons, Bianca Fileborn, Victor Minichiello, Catherine Barrett, Graham Brown, Sharron Hinchliff, Sue Malta, Pauline Crameri
Background: Rates of sexually transmissible infections (STIs) are increasing among older adults in many countries. Little is known about the testing and treatment histories of these populations. Correlates of testing in the past 5 years among older adults who may be at risk of a STI were examined. Methods: A cross-sectional survey of 2137 Australians aged 60+ years that involved questions on STIs and STI testing was conducted in 2015. To help inform potential education campaigns, analyses focused on those who may have been at risk of a STI (n=805, 38%)...
December 5, 2016: Sexual Health
https://www.readbyqxmd.com/read/27914204/the-genetic-architecture-of-tristyly-and-its-breakdown-to-self-fertilization
#14
Ramesh Arunkumar, Wei Wang, Stephen I Wright, Spencer C H Barrett
The floral polymorphism tristyly involves three style morphs with a reciprocal arrangement of stigma and anther heights governed by two diallelic loci (S and M). Tristyly functions to promote cross-pollination, but modifications to stamen position commonly cause transitions to selfing. Here, we integrate whole genome sequencing and genetic mapping to investigate the genetic architecture of the M locus and the genetic basis of independent transitions to selfing in tristylous Eichhornia paniculata. We crossed independently derived semi-homostylous selfing variants of the long- and mid-styled morph fixed for alternate alleles at the M locus (ssmm and ssMM, respectively) and backcrossed the F1 to the parental ssmm genotype...
December 3, 2016: Molecular Ecology
https://www.readbyqxmd.com/read/27914083/antibody-guided-molecular-imaging-of-infective-endocarditis
#15
Kenneth L Pinkston, Peng Gao, Kavindra V Singh, Ali Azhdarinia, Barbara E Murray, Eva M Sevick-Muraca, Barrett R Harvey
In this protocol, we describe the application of using a high affinity monoclonal antibody generated against the major pilin protein component of the pilin structure of Enterococcus faecalis as a PET imaging agent for enterococcal endocarditis detection. The anti-pilin -mAb 64Cu conjugate was able to specifically label enterococcal endocarditis vegetation in vivo in a rodent endocarditis model. By targeting pili, a covalently linked surface antigen extending from the bacterial surface, we provided evidence that gram-positive pilin represent a logical surface antigen to define or target an infectious agent for molecularly guided imaging...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27909927/fungal-biomass-as-biosorbent-for-the-removal-of-acid-blue-161-dye-in-aqueous-solution
#16
Mayerly Johana Puchana-Rosero, Eder C Lima, Santiago Ortiz-Monsalve, Bianca Mella, Dimitrius da Costa, Eduardo Poll, Mariliz Gutterres
Physical and thermal treatment was used to inactivate Trametes sp. SC-10 fungus. The resulting biomass was named BTV, characterized by analytical techniques such as SEM, EDX, FTIR, BET, and Barrett-Joyner-Halenda (BJH) model. pH, kinetic, and equilibrium adsorption studies with the Acid Blue 161 (AB-161) dye were investigated at 303.15 K. The kinetics of the biosorption process were examined at 600.00 and 1300 mg L(-1), using pseudo-first-order, pseudo-second-order, and Avrami fractional-order models. The maximum biosorption capacity of BTV for AB-161 dye was 221...
December 2, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27909366/standing-on-the-precipice-evaluating-final-year-physiotherapy-students-perspectives-of-their-curriculum-as-preparation-for-primary-health-care-practice
#17
Sinead McMahon, Grainne O'Donoghue, Catherine Doody, Geraldine O'Neill, Terry Barrett, Tara Cusack
Purpose: To explore final-year physiotherapy students' perceptions of primary health care practice to determine (1) aspects of their curriculum that support their learning, (2) deficiencies in their curriculum, and (3) areas that they believe should be changed to adequately equip them to make the transition from student to primary health care professional. Methods: Framework analysis methodology was used to analyze group opinion obtained using structured group feedback sessions. Sixty-eight final-year physiotherapy students from the four higher education institutions in Ireland participated...
2016: Physiotherapy Canada. Physiothérapie Canada
https://www.readbyqxmd.com/read/27908070/physical-constraints-of-cultural-evolution-of-dialects-in-killer-whales
#18
Olga A Filatova, Filipa I P Samarra, Lance G Barrett-Lennard, Patrick J O Miller, John K B Ford, Harald Yurk, Craig O Matkin, Erich Hoyt
Odontocete sounds are produced by two pairs of phonic lips situated in soft nares below the blowhole; the right pair is larger and is more likely to produce clicks, while the left pair is more likely to produce whistles. This has important implications for the cultural evolution of delphinid sounds: the greater the physical constraints, the greater the probability of random convergence. In this paper the authors examine the call structure of eight killer whale populations to identify structural constraints and to determine if they are consistent among all populations...
November 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27906837/different-impacts-of-hypertension-and-diabetes-mellitus-on-all-cause-and-cardiovascular-mortality-in-community-dwelling-older-adults-the-rancho-bernardo-study
#19
Jee-Young Oh, Matthew A Allison, Elizabeth Barrett-Connor
OBJECTIVES: Although the prevalence rates of hypertension (HTN) and diabetes mellitus are slowing in some high-income countries, HTN and diabetes mellitus remain as the two major risk factors for atherosclerotic cardiovascular disease (CVD), the leading cause of death in the United States and worldwide. We aimed to observe the association of HTN and diabetes mellitus with all-cause and CVD mortality in older white adults. METHODS: All community-dwelling Rancho Bernardo Study participants who were at least 55 years old and had carefully measured blood pressure and plasma glucose from 75-g oral glucose tolerance test at the baseline visit (1984-1987, n = 2186) were followed up until death or the last clinic visit in 2013 (median 14...
January 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/27905277/connecting-pm2-5-exposure-to-insulin-resistance-oxidative-stress-may-be-an-intermediate-step
#20
Julia R Barrett
No abstract text is available yet for this article.
December 1, 2016: Environmental Health Perspectives
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