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https://www.readbyqxmd.com/read/29351915/chronic-hip-pain
#1
Heather White, Michael Barrett, Christopher Gooding
No abstract text is available yet for this article.
January 19, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29351886/self-harm-among-the-homeless-population-in-ireland-a-national-registry-based-study-of-incidence-and-associated-factors
#2
Peter Barrett, Eve Griffin, Paul Corcoran, Mary T O'Mahony, Ella Arensman
BACKGROUND: Self-harm is a strong predictor of future suicide, but little is known about self-harm among the homeless population. The study aim was to estimate the incidence of self-harm among the homeless population and to assess factors associated with self-harm. METHODS: Data on self-harm presentations to 34 hospital emergency departments in Ireland were collected by the National Self-Harm Registry Ireland (NSHRI). Index presentations between 2010 and 2014 were included for the homeless and fixed residence populations...
December 27, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29351773/treatment-of-long-segment-barrett-s-adenocarcinoma-by-complete-circular-endoscopic-submucosal-dissection-a-case-report
#3
Miki Kaneko, Akira Mitoro, Motoyuki Yoshida, Masayoshi Sawai, Yasushi Okura, Masanori Furukawa, Tadashi Namisaki, Kei Moriya, Takemi Akahane, Hideto Kawaratani, Mitsuteru Kitade, Kousuke Kaji, Hiroaki Takaya, Yasuhiko Sawada, Kenichiro Seki, Shinya Sato, Tomomi Fujii, Junichi Yamao, Chiho Obayashi, Hitoshi Yoshiji
BACKGROUND: We present the first description of en bloc endoscopic submucosal dissection (ESD) for total circumferential Barrett's adenocarcinoma, predominantly of the long-segment Barrett's esophagus (LSBE), with a 2-year follow-up and management strategies for esophageal stricture prevention. CASE PRESENTATION: A 59-year-old man was diagnosed with LSBE and Barrett's adenocarcinoma by esophagogastroduodenoscopy (EGD). A 55-mm-long circumferential tumor was completely resected by ESD...
January 19, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29351156/liquid-nitrogen-spray-cryotherapy-is-associated-with-less-postprocedural-pain-than-radiofrequency-ablation-in-barrett-s-esophagus-a-multicenter-prospective-study
#4
Sanjeev S Solomon, Shivangi Kothari, George B Smallfield, Sumant Inamdar, Peter Stein, Viviana A Rodriguez, Adam P Sima, Krystle Bittner, Alvin M Zfass, Vivek Kaul, Arvind J Trindade
GOALS AND BACKGROUND: Two common endoscopic therapies for eradication of dysplastic Barrett's esophagus are radiofrequency ablation (RFA) and liquid nitrogen spray cryotherapy (LNC). There is no data comparing postprocedural pain. This study aimed to compare the incidence of postprocedural pain between the 2 ablation modalities. METHODS: This is a multicenter prospective study in which pain intensity scores and the presence of dysphagia were assessed immediately before and after treatment, 48 hours posttreatment and at 3 weeks posttreatment using validated instruments...
January 18, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29351056/remediation-of-radiation-induced-cognitive-dysfunction-through-oral-administration-of-the-neuroprotective-compound-nsi-189
#5
Barrett Allen, Munjal M Acharya, Celine Lu, Erich Giedzinski, Nicole Chmielewski, David Quach, Mike Hefferan, Karl K Johe, Charles L Limoli
Clinical management of primary and secondary central nervous system (CNS) malignancies frequently includes radiotherapy to forestall tumor growth and recurrence after surgical resection. While cranial radiotherapy remains beneficial, adult and pediatric brain tumor survivors suffer from a wide range of debilitating and progressive cognitive deficits. Although this has been recognized as a significant problem for decades, there remains no clinical recourse for the unintended neurocognitive sequelae associated with these types of cancer treatments...
January 19, 2018: Radiation Research
https://www.readbyqxmd.com/read/29350339/emerging-insights-into-the-esophageal-microbiome
#6
REVIEW
Michael May, Julian A Abrams
PURPOSE OF REVIEW: Analysis of the esophageal microbiome remains a relatively new field of research, and most studies to date have focused on characterizing the esophageal microbiome in states of health and disease. Microbiome alterations have been implicated in the pathogenesis of inflammatory and neoplastic conditions in the colon and elsewhere in the gastrointestinal tract. The epidemiology of various esophageal conditions including Barrett's esophagus (BE), esophageal adenocarcinoma (EAC), esophageal squamous cell carcinoma (ESCC), and eosinophilic esophagitis (EoE) point to the microbiome as a potential co-factor in disease pathogenesis, and the possibility exists that these microbiome alterations could contribute directly to the inflammatory environments necessary for the carcinogenesis or atopy involved in these conditions...
January 19, 2018: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/29350246/data-driven-quality-improvement-project-to-increase-the-value-of-the-congenital-echocardiographic-report
#7
Pei-Ni Jone, Ruthanne Gould, Cindy Barrett, Adel K Younoszai, Brian Fonseca
Echocardiography is the primary diagnostic modality for congenital heart disease patients. The written report is used to communicate with the care team and organization is often divided into the body with detailed findings and the conclusions with important findings summarized. Strategies to increase workflow efficiency include batch writing of reports after performance of multiple echocardiograms and the use of report templates which may contribute to discrepancies within report leading to potential downstream medical errors...
January 19, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29348681/impact-of-a-five-dimensional-framework-on-r-d-productivity-at-astrazeneca
#8
REVIEW
Paul Morgan, Dean G Brown, Simon Lennard, Mark J Anderton, J Carl Barrett, Ulf Eriksson, Mark Fidock, Bengt Hamrén, Anthony Johnson, Ruth E March, James Matcham, Jerome Mettetal, David J Nicholls, Stefan Platz, Steve Rees, Michael A Snowden, Menelas N Pangalos
In 2011, AstraZeneca embarked on a major revision of its research and development (R&D) strategy with the aim of improving R&D productivity, which was below industry averages in 2005-2010. A cornerstone of the revised strategy was to focus decision-making on five technical determinants (the right target, right tissue, right safety, right patient and right commercial potential). In this article, we describe the progress made using this '5R framework' in the hope that our experience could be useful to other companies tackling R&D productivity issues...
January 19, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29348260/the-canadian-preterm-birth-network-a-study-protocol-for-improving-outcomes-for-preterm-infants-and-their-families
#9
Prakesh S Shah, Sarah D McDonald, Jon Barrett, Anne Synnes, Kate Robson, Jonathan Foster, Jean-Charles Pasquier, K S Joseph, Bruno Piedboeuf, Thierry Lacaze-Masmonteil, Karel O'Brien, Sandesh Shivananda, Nils Chaillet, Petros Pechlivanoglou
BACKGROUND: Preterm birth (birth before 37 wk of gestation) occurs in about 8% of pregnancies in Canada and is associated with high mortality and morbidity rates that substantially affect infants, their families and the health care system. Our overall goal is to create a transdisciplinary platform, the Canadian Preterm Birth Network (CPTBN), where investigators, stakeholders and families will work together to improve childhood outcomes of preterm neonates. METHODS: Our national cohort will include 24 maternal-fetal/obstetrical units, 31 neonatal intensive care units and 26 neonatal follow-up programs across Canada with planned linkages to provincial health information systems...
January 18, 2018: CMAJ Open
https://www.readbyqxmd.com/read/29346925/cluster-sizes-in-a-classical-lennard-jones-chain
#10
G R Lee-Dadswell, Nicholas Barrett, Michael Power
The definitions of breaks and clusters in a one-dimensional chain in equilibrium are discussed. Analytical expressions are obtained for the expected cluster length, 〈K〉, as a function of temperature and pressure in a one-dimensional Lennard-Jones chain. These expressions are compared with results from molecular dynamics simulations. It is found that 〈K〉 increases exponentially with β=1/k_{B}T and with pressure, P in agreement with previous results in the literature. A method is illustrated for using 〈K〉(β,P) to generate a "phase diagram" for the Lennard-Jones chain...
September 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346553/prediction-of-barrett-s-esophagus-are-we-there-yet
#11
S Gaddam
No abstract text is available yet for this article.
January 13, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29346522/serious-fall-injury-history-and-adverse-health-outcomes-after-initiating-hemodialysis-among-older-u-s-adults
#12
C Barrett Bowling, Rasheeda Hall, Anjali Khakharia, Harold A Franch, Laura C Plantinga
Background: Although older adults with pre-dialysis chronic kidney disease (CKD) are at higher risk for falls, the prognostic significance of a serious fall injury prior to dialysis initiation has not been well described in the end-stage renal disease population. Methods: We examined the association between a serious fall injury in the year prior to starting hemodialysis and adverse health outcomes in the year following dialysis initiation using a retrospective cohort study of U...
January 16, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29344988/recent-advances-in-articular-cartilage-evaluation-using-computed-tomography-and-magnetic-resonance-imaging
#13
REVIEW
B B Nelson, C E Kawcak, M F Barrett, C W McIlwraith, M W Grinstaff, L R Goodrich
Articular cartilage is a critical joint tissue and its evaluation remains a diagnostic challenge in horses. Coupled with a poor capacity for healing, early degenerative changes in articular cartilage are difficult to characterise using routine diagnostic imaging evaluations. Computed tomography (CT) and magnetic resonance imaging (MRI) both provide volumetric joint assessment and highlight morphologic and quantitative properties of articular cartilage, improving assessment of this essential tissue. While the use of CT and MRI for joint evaluation is not new, there still remains a shortage of literature and scientific studies on the ability of these methods to evaluate articular cartilage in the horse...
January 17, 2018: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29344692/the-epidemiology-of-wrist-fractures-in-older-men-the-osteoporotic-fractures-in-men-mros-study
#14
N C Wright, E R Hooker, C M Nielson, K E Ensrud, S L Harrison, E S Orwoll, E Barrett-Connor
There is limited wrist fracture information on men. Our goal was to calculate frequency and identify risk factors for wrist fracture in the Osteoporotic Fractures in Men (MrOS) study. We confirmed that fracture history and certain medications are predictors, and identified novel predictors including markers of kidney function and physical performance. INTRODUCTION: To calculate the incidence of wrist fractures and their risk factors in older community-dwelling men from the US Osteoporotic Fractures in Men (MrOS) study...
January 17, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29343623/identifying-dna-methylation-biomarkers-for-non-endoscopic-detection-of-barrett-s-esophagus
#15
Helen R Moinova, Thomas LaFramboise, James D Lutterbaugh, Apoorva Krishna Chandar, John Dumot, Ashley Faulx, Wendy Brock, Omar De la Cruz Cabrera, Kishore Guda, Jill S Barnholtz-Sloan, Prasad G Iyer, Marcia I Canto, Jean S Wang, Nicholas J Shaheen, Prashanti N Thota, Joseph E Willis, Amitabh Chak, Sanford D Markowitz
We report a biomarker-based non-endoscopic method for detecting Barrett's esophagus (BE) based on detecting methylated DNAs retrieved via a swallowable balloon-based esophageal sampling device. BE is the precursor of, and a major recognized risk factor for, developing esophageal adenocarcinoma. Endoscopy, the current standard for BE detection, is not cost-effective for population screening. We performed genome-wide screening to ascertain regions targeted for recurrent aberrant cytosine methylation in BE, identifying high-frequency methylation within the CCNA1 locus...
January 17, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29342490/detection-of-early-neoplasia-in-barrett-s-esophagus-using-lectin-based-near-infrared-imaging-an-ex-vivo-study-on-human-tissue
#16
André A Neves, Massimiliano Di Pietro, Maria O'Donovan, Dale J Waterhouse, Sarah E Bohndiek, Kevin M Brindle, Rebecca C Fitzgerald
BACKGROUND AND STUDY AIMS:  Endoscopic surveillance for Barrett's esophagus (BE) is limited by long procedure times and sampling error. Near-infrared (NIR) fluorescence imaging minimizes tissue autofluorescence and optical scattering. We assessed the feasibility of a topically applied NIR dye-labeled lectin for the detection of early neoplasia in BE in an ex vivo setting. METHODS:  Consecutive patients undergoing endoscopic mucosal resection (EMR) for BE-related early neoplasia were recruited...
January 17, 2018: Endoscopy
https://www.readbyqxmd.com/read/29342161/association-between-circulating-levels-of-sex-steroid-hormones-and-esophageal-adenocarcinoma-in-the-finbar-study
#17
Jessica L Petrick, Roni T Falk, Paula L Hyland, Patrick Caron, Ruth M Pfeiffer, Shannon N Wood, Sanford M Dawsey, Christian C Abnet, Philip R Taylor, Chantal Guillemette, Liam J Murray, Lesley A Anderson, Michael B Cook
BACKGROUND: Esophageal adenocarcinoma (EA) is characterized by a strong male predominance. Sex steroid hormones have been hypothesized to underlie this sex disparity, but no population-based study to date has examined this potential association. METHODS: Using mass spectrometry and ELISA, we quantitated sex steroid hormones and sex hormone binding globulin, respectively, in plasma from males- 172 EA cases and 185 controls-within the Factors Influencing the Barrett/Adenocarcinoma Relationship (FINBAR) Study, a case-control investigation conducted in Northern Ireland and Ireland...
2018: PloS One
https://www.readbyqxmd.com/read/29341516/epithelioid-angiomyolipoma-a-case-report-and-review-of-the-literature
#18
F Keane, M Greally, E Harrold, C Barrett, J McCaffrey
Herein we present the case of a 43-year-old female in whom a left renal mass was identified incidentally on imaging performed for staging of a newly diagnosed breast carcinoma. The mass was resected and histologic examination and immunohistochemistry confirmed a diagnosis of epithelioid angiomyolipoma.
August 8, 2017: Irish Medical Journal
https://www.readbyqxmd.com/read/29341515/the-uptake-of-human-papillomavirus-vaccine-in-irish-schools-the-impact-of-disadvantage
#19
C Migone, T Barrett, S Cotter, A Clarke, B Corcoran
HPV vaccine Gardasil© is offered to girls in first year of secondary school in Ireland. We aimed to determine the association between HPV vaccine uptake among girls for academic year 2013/2014, by school and school characteristics: socioeconomic disadvantage and religious ethos. The National Schools Immunisation System (SIS) was searched to determine HPV vaccine uptake in schools for 2013/2014 (prior to recent anti-HPV vaccine publicity). The disadvantaged status and ethos of each school was added to the report...
August 8, 2017: Irish Medical Journal
https://www.readbyqxmd.com/read/29341356/all-over-the-map-an-interobserver-agreement-study-of-tumor-location-based-on-the-pi-radsv2-sector-map
#20
Matthew D Greer, Joanna H Shih, Tristan Barrett, Sandra Bednarova, Ismail Kabakus, Yan Mee Law, Haytham Shebel, Maria J Merino, Bradford J Wood, Peter A Pinto, Peter L Choyke, Baris Turkbey
BACKGROUND: Prostate imaging reporting and data system version 2 (PI-RADSv2) recommends a sector map for reporting findings of prostate cancer mulitparametric MRI (mpMRI). Anecdotally, radiologists may demonstrate inconsistent reproducibility with this map. PURPOSE: To evaluate interobserver agreement in defining prostate tumor location on mpMRI using the PI-RADSv2 sector map. STUDY TYPE: Retrospective. POPULATION: Thirty consecutive patients who underwent mpMRI between October, 2013 and March, 2015 and who subsequently underwent prostatectomy with whole-mount processing...
January 17, 2018: Journal of Magnetic Resonance Imaging: JMRI
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