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https://www.readbyqxmd.com/read/29238875/pepsin-in-saliva-as-a-diagnostic-biomarker-in-laryngopharyngeal-reflux-a-meta-analysis
#1
REVIEW
Jing Wang, Yu Zhao, Jianjun Ren, Yang Xu
OBJECTIVE: Pepsin in saliva has been proposed as a biomarker for the diagnosis of laryngopharyngeal reflux (LPR), but the results remain controversial. We assessed the diagnostic value of pepsin in saliva for LPR. METHODS: PubMed, Embase, and Web of Science were searched for studies in English that evaluated the utility of pepsin in saliva in the diagnosis of LPR, published up to 15 March 2017. We used Stata 12.0 to summarize the diagnostic indexes for the meta-analysis...
December 13, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29230863/characterization-of-a-nilaparvata-lugens-st%C3%A3-l-brummer-gene-and-analysis-of-its-role-in-lipid-metabolism
#2
Jinming Zhou, Jing Yan, Keke You, Xia Chen, Zhineng Yuan, Qiang Zhou, Kai Lu
The brummer (bmm) genes encode the lipid storage droplet-associated triacylglycerols (TAG) lipases, which belong to the Brummer/Nutrin subfamily. These enzymes hydrolyze the ester bonds in TAG in lipid metabolism and act in insect energy homeostasis. Exposure to some agricultural chemicals leads to increased fecundity, which necessarily involves lipid metabolism, in some planthopper species. However, the biological roles of bmm in planthopper lipid storage and mobilization have not been investigated. Here, the open reading frame (ORF) of bmm (Nlbmm) was cloned and sequenced from the brown planthopper (BPH; Nilaparvata lugens)...
December 12, 2017: Archives of Insect Biochemistry and Physiology
https://www.readbyqxmd.com/read/29218658/hypopharyngeal-multichannel-intraluminal-impedance-leads-to-the-promising-outcome-of-antireflux-surgery-in-japanese-population-with-laryngopharyngeal-reflux-symptoms
#3
Takeshi Suzuki, Yosuke Seki, Yoshitaka Okamoto, Toshitaka Hoppo
BACKGROUND: Clinical characteristics of laryngopharyngeal reflux (LPR) in Japanese population remain unclear, and its treatment outcome is suboptimal. The objectives of this study were to evaluate Japanese patients with LPR symptoms using hypopharyngeal multichannel intraluminal impedance (HMII) and to assess the outcome of antireflux surgery (ARS). METHODS: Subjects included patients who had LPR symptoms for > 12 weeks or laryngoscopic findings suggestive of LPR and underwent laryngoscopy and esophageal testing including HMII...
December 7, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29181000/prenatal-administration-of-betamethasone-causes-changes-in-the-t-cell-receptor-repertoire-influencing-development-of-autoimmunity
#4
Anna Gieras, Christina Gehbauer, David Perna-Barrull, Jan Broder Engler, Ines Diepenbruck, Laura Glau, Simon A Joosse, Nora Kersten, Stefanie Klinge, Hans-Willi Mittrücker, Manuel A Friese, Marta Vives-Pi, Eva Tolosa
Prenatal glucocorticoids are routinely administered to pregnant women at risk of preterm delivery in order to improve survival of the newborn. However, in half of the cases, birth occurs outside the beneficial period for lung development. Glucocorticoids are potent immune modulators and cause apoptotic death of immature T cells, and we have previously shown that prenatal betamethasone treatment at doses eliciting lung maturation induce profound thymocyte apoptosis in the offspring. Here, we asked if there are long-term consequences on the offspring's immunity after this treatment...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29174850/association-between-pepsin-in-the-saliva-and-the-subjective-symptoms-in-patients-with-laryngopharyngeal-reflux
#5
Ah Ra Jung, Oh Eun Kwon, Jung Min Park, Sung Hwa Dong, Su Young Jung, Young Chan Lee, Young-Gyu Eun
OBJECTIVES: Our study was designed to further evaluate the relationships between the saliva pepsin level and the symptoms and quality of life of patients with laryngopharyngeal reflux (LPR). STUDY DESIGN: A prospective cohort study without controls. SETTING: Tertiary teaching hospital. SUBJECTS AND METHODS: We analyzed 50 patients diagnosed with LPR by 24-hour multichannel intraluminal impedance pH monitoring. All subjects were instructed to collect saliva samples upon waking in the morning...
November 24, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/29168025/relationship-between-the-severity-of-laryngopharyngeal-reflux-and-sleep-apnea-using-drug-induced-sleep-endoscopy-dise
#6
Joong Seob Lee, Sung Jae Heo, Jung Soo Kim, Dongbin Ahn, Jin Ho Sohn, Heejin Kim
OBJECTIVES: The aim of the study is to identify the following associations: (1) severity of obstructive sleep apnea syndrome (OSAS) and laryngopharyngeal reflux (LPR)-related clinical parameters, such as reflux finding score (RFS), reflux symptom index (RSI), and LPR-health-related quality of life (LPR-HRQOL) and (2) complete obstruction on drug-induced sleep endoscopy (DISE) and LPR-related clinical parameters. MATERIALS AND METHODS: Subjects included the OSAS patients without surgery history and all patients perform the polysomnography (PSG) and DISE for their OSAS...
November 22, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29167408/conjugated-linoleic-acid-prevents-age-dependent-neurodegeneration-in-a-mouse-model-of-neuropsychiatric-lupus-via-the-activation-of-an-adaptive-response
#7
Antonio Monaco, Ida Ferrandino, Floriana Boscaino, Ennio Cocca, Luisa Cigliano, Francesco Maurano, Diomira Luongo, Maria Stefania Spagnuolo, Mauro Rossi, Paolo Bergamo
Oxidative stress is a key mediator of autoimmune/neurodegenerative disorders. The antioxidant/anti-inflammatory effect of a synthetic conjugated linoleic acid (CLA) mixture in MRL/MpJ-Faslpr mice (MRL/lpr), an animal model of neuropsychiatric lupus, was previously associated with the improvement of Nuclear factor-E2-related factor 2 (Nrf2) defences in the spleen and liver. However, little is known about the neuroprotective ability of CLA mixture. This study investigates the age-dependent progression of oxidative stress and the hyperactivation of redox-sensitive compensatory pathways (macroautophagy, Nrf2) in old/diseased MRL/lpr mice brains, and examines the effect produced by dietary CLA supplementation...
November 22, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/29159556/effects-of-arsenic-trioxide-on-inf-gamma-gene-expression-in-mrl-lpr-mice-and-human-lupus
#8
Hongye Hu, Enjiu Chen, Yongji Li, Xiaochun Zhu, Ting Zhang, Xiaofang Zhu
Arsenic trioxide (As2O3; ATO), a traditional Chinese medicine, is used to treat patients with acute promye-locytic leukemia, while its application for treatment of systemic lupus erythematosus (SLE) is still under evaluation. The high expression of INF-gamma (INF-γ) is a primary pathogenic factor in SLE. It is found that ATO can reduce INF-γ expression levels in lupus-prone mice, whereas it is not clear whether ATO has the same effect on SLE patients. Therefore, this study was to investigate the underlying mechanism of the effects of ATO on the expression of INF-γ in splenocytes of MRL/lpr mice and PBMCs of human lupus...
November 20, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/29141242/chloroquine-autophagic-inhibition-rebalances-th17-treg-mediated-immunity-and-ameliorates-systemic-lupus-erythematosus
#9
Ning An, Yanwen Chen, Chao Wang, Chen Yang, Zhi-Hong Wu, Jing Xue, Lin Ye, Shujun Wang, Hua-Feng Liu, Qingjun Pan
BACKGROUND: Imbalanced cellular immunity is critical to the pathogenesis of systemic lupus erythematosus (SLE). Recently, autophagy has emerged as a key homeostatic mechanism in T lymphocytes. This study was conducted to explore the impact of autophagy on the Th17/ regulatory T (Treg) immune imbalance in SLE. METHODS: Peripheral Th17 and Treg cells from newly diagnosed patients with SLE and healthy controls were detected by flow cytometry. Additionally, the effects of chloroquine (CQ) autophagic inhibition on the Th17/Treg immune response were investigated in vitro...
November 14, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29138852/anti%C3%A2-il%C3%A2-39-il%C3%A2-23p19-ebi3-polyclonal-antibodies-ameliorate-autoimmune-symptoms-in-lupus%C3%A2-like-mice
#10
Xiaoqian Wang, Yu Zhang, Zhiding Wang, Xiaoling Liu, Gaizhi Zhu, Gencheng Han, Guojiang Chen, Chunmei Hou, Tianxiao Wang, Beifen Shen, Yan Li, He Xiao, Ning Ma, Renxi Wang
The interleukin (IL)‑12 family cytokines have been examined as therapeutic targets in the treatment of several autoimmune diseases. Our previous study showed that a novel IL‑12 family cytokine, IL‑39 (IL‑23p19/Ebi3) mediates inflammation in lupus‑like mice. In the present study, the effect of anti‑mouse IL‑39 polyclonal antibodies on autoimmune symptoms in lupus‑like mice was investigated. Rabbit anti‑mouse IL‑39 polyclonal antibodies were produced by immunization with recombinant mouse IL‑39, and purified using protein A chromatography...
November 14, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29111236/reprint-of-dual-blockade-of-the-pro-inflammatory-chemokine-ccl2-and-the-homeostatic-chemokine-cxcl12-is-as-effective-as-high-dose-cyclophosphamide-in-murine-proliferative-lupus-nephritis
#11
Satish Kumar Devarapu, Santhosh Kumar Vr, Khader Valli Rupanagudi, Onkar P Kulkarni, Dirk Eulberg, Sven Klussmann, Hans-Joachim Anders
Induction therapy of proliferative lupus nephritis still requires the use of unselective immunosuppressive drugs with significant toxicities. In search of more specific drugs with equal efficacy but fewer side effects we considered blocking pro-inflammatory chemokine monocyte chemoattractant protein-1 (MCP-1/CCL2) and homeostatic chemokine stromal cell-derived factor-1 (SDF-1/CXCL12), which both contribute to the onset and progression of proliferative lupus nephritis yet through different mechanisms. We hypothesized that dual antagonism could be as potent on lupus nephritis as the unselective immunosuppressant cyclophosphamide (CYC)...
October 27, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/29102373/transcriptomic-analysis-uncovers-novel-synergistic-mechanisms-in-combination-therapy-for-lupus-nephritis
#12
Jia Fu, Zichen Wang, Kyung Lee, Chengguo Wei, Zhengzhao Liu, Mingchao Zhang, Minlin Zhou, Minchao Cai, Weijia Zhang, Peter Y Chuang, Avi Ma'ayan, John Cijiang He, Zhihong Liu
A recent clinical study showed that combination therapy consisting of mycophenolate mofetil, tacrolimus and steroids was shown to be more effective in achieving complete remission in patients with severe forms of lupus nephritis than conventional therapy consisting of intravenous cyclophosphamide and steroids. To explore the underlying molecular and cellular mechanisms of increased efficacy of the combination therapy regimen, we employed a mouse model of lupus nephritis, MRL/lpr mice, and treated them with monotherapies of prednisone, mycophenolate mofetil, or tacrolimus, or with their combination...
November 1, 2017: Kidney International
https://www.readbyqxmd.com/read/29100672/treating-laryngopharyngeal-reflux-evaluation-of-an-anti-reflux-program-with-comparison-to-medications
#13
Jin Yang, Salem Dehom, Stephanie Sanders, Thomas Murry, Priya Krishna, Brianna K Crawley
OBJECTIVE: To determine if an anti-reflux induction program relieves laryngopharyngeal reflux (LPR) symptoms more effectively than medication and behavioral changes alone. STUDY DESIGN: Retrospective study. SETTING: Tertiary care academic center. SUBJECTS AND METHODS: A database was populated with patients treated for LPR. Patients were included in the study group if they completed a two-week anti-reflux program (diet, alkaline water, medications, behavioral modifications)...
October 31, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29098155/quantifying-laryngopharyngeal-reflux-in-singers-perceptual-and-objective-findings
#14
Adam T Lloyd, Bari Hoffman Ruddy, Erin Silverman, Vicki M Lewis, Jeffrey J Lehman
This study examines the relationship between laryngopharyngeal reflux (LPR) symptoms and oropharyngeal pH levels in singers. We hypothesized that reported symptoms would correlate with objective measures of pH levels from the oropharynx, including the number and total duration of reflux episodes. Twenty professional/semiprofessional singers completed the Reflux Symptom Index (RSI) and underwent oropharyngeal pH monitoring. Mild, moderate, or severe pH exposure was recorded during oropharyngeal pH monitoring...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29072674/comparison-of-impedance-and-pepsin-detection-in-the-laryngeal-mucosa-to-determine-impedance-values-that-indicate-pathological-laryngopharyngeal-reflux
#15
Martin Formánek, Debora Jančatová, Pavel Komínek, Radoslava Tomanová, Karol Zeleník
OBJECTIVE: Recently, a 24-h impedance was used to detect laryngopharyngeal reflux (LPR). However, not every case of LPR is pathological. Thus, pathological pharyngeal impedance values need to be clearly established to diagnose pathological LPR. The aim of our study was to establish pathological 24-h pharyngoesophageal impedance/pH values for the diagnosis of LPR. METHODS: The study was conducted in a tertiary care setting. A total of 30 patients who were referred to microlaryngoscopy for a laryngeal pathology that might be caused by LPR were included in this prospective study...
October 26, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29061118/high-resolution-manometry-in-patients-with-and-without-globus-pharyngeus-and-or-symptoms-of-laryngopharyngeal-reflux
#16
Heyan Ding, Zhijun Duan, Dong Yang, Zhifeng Zhang, Lixia Wang, Xiaoyu Sun, Yiwen Yao, Xue Lin, Hang Yang, Shan Wang, Jiande D Z Chen
BACKGROUND: Globus pharyngeus is common and has a low cure rate. Its etiology is complex and reported to be associated with laryngopharyngeal reflux (LPR). However, some patients with globus do not exhibit any reflux symptoms or respond to proton pump inhibitors (PPIs) treatments. The purpose of this study was to clarify the related risk factors of these patients with a final objective of improving the curative effect. METHODS: Forty two patients afflicted with globus pharyngeus (G group) and 38 patients without globus pharyngeus (NG group) were included in this study...
October 23, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29057975/antibiotics-ameliorate-lupus-like-symptoms-in-mice
#17
Qinghui Mu, Vincent J Tavella, Jay L Kirby, Thomas E Cecere, Matthias Chung, Jiyoung Lee, Song Li, S Ansar Ahmed, Kristin Eden, Irving Coy Allen, Christopher M Reilly, Xin M Luo
Gut microbiota and the immune system interact to maintain tissue homeostasis, but whether this interaction is involved in the pathogenesis of systemic lupus erythematosus (SLE) is unclear. Here we report that oral antibiotics given during active disease removed harmful bacteria from the gut microbiota and attenuated SLE-like disease in lupus-prone mice. Using MRL/lpr mice, we showed that antibiotics given after disease onset ameliorated systemic autoimmunity and kidney histopathology. They decreased IL-17-producing cells and increased the level of circulating IL-10...
October 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29024410/eight-weeks-of-omeprazole-20-mg-significantly-reduces-both-laryngopharyngeal-reflux-and-comorbid-chronic-rhinosinusitis-signs-and-symptoms-randomised-double-blind-placebo-controlled-trial
#18
S A Anzić, M Turkalj, A Župan, M Labor, D Plavec, T Baudoin
OBJECTIVES: Gastroesophageal reflux recommended treatment (dose and duration) with proton-pump inhibitor (PPI) compared to placebo significantly reduces the signs and symptoms of laryngopharyngeal reflux (LPR) and comorbid chronic rhinosinusitis (CRS). DESIGN: Double-blind randomised placebo-controlled trial. SETTING: Eight weeks of treatment with omeprazole 20 mg once daily (OD). PARTICIPANTS: Sixty patients (28 women, aged 19-87 years) with diagnosed LPR and comorbid CRS...
October 11, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28993603/comparison-of-characteristics-according-to-reflux-type-in-patients-with-laryngopharyngeal-reflux
#19
Jun Seok Lee, Ah Ra Jung, Jung Min Park, Myung Jin Park, Young Chan Lee, Young-Gyu Eun
Objectives: To analyze laryngopharyngeal reflux (LPR) as an acidic, nonacidic, or mixed type according to 24-hour multichannel intraluminal impedance (MII) pH monitoring and the clinical characteristics of each type. Methods: Ninety patients were prospectively enrolled in this study. All patients underwent 24-hour MII pH monitoring as a diagnostic tool. Eighty-three patients were diagnosed with LPR. The patients were classified into three groups according to the pH of the hypopharyngeal probe: the acid reflux group, nonacid reflux group, and mixed reflux group...
October 10, 2017: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/28988334/a-systematic-review-of-cerebral-microdialysis-and-outcomes-in-tbi-relationships-to-patient-functional-outcome-neurophysiologic-measures-and-tissue-outcome
#20
REVIEW
Frederick A Zeiler, Eric Peter Thelin, Adel Helmy, Marek Czosnyka, Peter J A Hutchinson, David K Menon
OBJECTIVE: To perform a systematic review on commonly measured cerebral microdialysis (CMD) analytes and their association to: (A) patient functional outcome, (B) neurophysiologic measures, and (C) tissue outcome; after moderate/severe TBI. The aim was to provide a foundation for next-generation CMD studies and build on existing pragmatic expert guidelines for CMD. METHODS: We searched MEDLINE, BIOSIS, EMBASE, Global Health, Scopus, Cochrane Library (inception to October 2016)...
October 7, 2017: Acta Neurochirurgica
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