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https://www.readbyqxmd.com/read/29450765/impact-of-platelet-reactivity-on-5-year-clinical-outcomes-following-percutaneous-coronary-intervention-a-landmark-analysis
#1
Fabio Mangiacapra, Iginio Colaiori, Elisabetta Ricottini, Antonio Creta, Giuseppe Di Gioia, Ilaria Cavallari, Edoardo Bressi, Marialessia Capuano, Emanuele Barbato, Germano Di Sciascio
We investigated the impact of suboptimal platelet reactivity on clinical outcomes after percutaneous coronary intervention (PCI). We enrolled 500 patients with stable coronary artery disease undergoing elective PCI. Platelet reactivity was measured before PCI using the VerifyNow P2Y12 assay. Primary endpoint was the incidence of ischemic or bleeding events at 1 month and 5 years. Patients with high platelet reactivity (HPR) showed significantly higher rates of ischemic events both during the 1st month after PCI (HR 2...
February 15, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29436212/correlation-between-the-reflux-finding-score-and-the-reflux-symptom-index-in-patients-with-laryngopharyngeal-reflux
#2
M Gelardi, M Silvestri, G Ciprandi
LaryngoPharyngeal Reflux (LPR) is characterized by symptoms, signs, and/or tissue damage resulting from the aggression of the gastrointestinal contents in the upper airways. The Reflux Finding Score (RFS) assesses the laryngeal signs through laryngoscopy. The Reflux Symptom Index (RSI) scores the LPR symptoms. The objective of this real-world study was to compare RFS with RSI in a cohort of Italian LPR patients. Globally, 3932 patients with LPR were evaluated and RFS and RSI were assessed in all subjects. A moderate correlation was found between RSI and RFS (r=0...
January 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29436211/relieving-laryngopharingeral-reflux-relief-survey-in-otolaryngology-ii-the-viewpoint-of-the-patient
#3
M Gelardi, M Silvestri, G Ciprandi
As LPR diagnostic work-up is complex in the absence of a definitive gold standard diagnostic test, patient symptoms have become a primary method to identify those with LPR. In this regard, Reflux Symptom Index (RSI) is a reliable self-administered questionnaire useful also to monitor changes after treatment. An Italian survey on patients with LPR evaluated the effect of treatments for LPR that were prescribed in a real-world setting, such as Otolaryngological clinics. In this part of the survey, 1,680 subjects [45...
January 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29436210/relieving-laryngopharingeral-reflux-relief-survey-in-otolaryngology-the-viewpoint-of-the-otorhinolaryngologist
#4
M Gelardi, M Silvestri, G Ciprandi
Laryngopharyngeal Reflux (LPR) should be considered as part of extraesophageal reflux (EER). This reflux involves respiratory structures other than, or in addition to, the oesophagus. A new medical device for the treatment of gastric reflux, including LPR, has been launched in Italy: Marial®. Therefore, the aim of the present survey was to analyse the prescriptive behaviour both considering the past or current treatments and clinical features during a specialist routine visit. The current survey was conducted in 86 Otorhinolaryngological centers, distributed in all of Italy...
January 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29436209/focus-on-gastroesophageal-reflux-ger-and-laryngopharyngeal-reflux-lpr-new-pragmatic-insights-in-clinical-practice
#5
M Gelardi, G Ciprandi
Gastroesophageal reflux (GER) is a common disease usually limited to the oesophagus. Laryngopharyngeal reflux (LPR) is an inflammatory reaction of the mucosa of pharynx, larynx, and other associated upper respiratory organs, caused by a reflux of stomach contents outside the oesophagus. LPR is considered to be a relatively new clinical entity with a vast number of clinical manifestations which are treated sometimes empirically and without a correct diagnosis. However, there is disagreement between specialists about its definition and management: gastroenterologists consider LPR to be a substantially rare manifestation of gastroesophageal reflux disease (GERD), whereas otolaryngologists believe that LPR is an independent, but common in their practice, disorder...
January 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29374508/re-engineering-and-evaluation-of-anti-dna-autoantibody-3e10-for-therapeutic-applications
#6
Zahra Rattray, Valentina Dubljevic, Nicholas J W Rattray, Deanne L Greenwood, Caroline H Johnson, James A Campbell, James E Hansen
A key challenge in the development of novel chemotherapeutics is the design of molecules capable of selective toxicity to cancer cells. Antibodies have greater target specificity compared to small molecule drugs, but most are unable to penetrate cells, and predominantly target extracellular antigens. A nuclear-penetrating anti-DNA autoantibody isolated from the MRL/lpr lupus mouse model, 3E10, preferentially localizes to tumors, inhibits DNA repair, and selectively kills cancer cells with defects in DNA repair...
January 24, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29370834/highly-selective-inhibition-of-bruton-s-tyrosine-kinase-attenuates-skin-and-brain-disease-in-murine-lupus
#7
Samantha A Chalmers, Jing Wen, Jessica Doerner, Ariel Stock, Carla M Cuda, Hadijat M Makinde, Harris Perlman, Todd Bosanac, Deborah Webb, Gerald Nabozny, Jay S Fine, Elliott Klein, Meera Ramanujam, Chaim Putterman
BACKGROUND: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that affects different end organs, including skin and brain. We and others have previously shown the importance of macrophages in the pathogenesis of cutaneous and neuropsychiatric lupus. Additionally, autoantibodies produced by autoreactive B cells are thought to play a role in both the skin and central nervous system pathologies associated with SLE. METHODS: We used a novel inhibitor of Bruton's tyrosine kinase (BTK), BI-BTK-1, to target both macrophage and B cell function in the MRL-lpr/lpr murine model of SLE, and examined the effect of treatment on skin and brain disease...
January 25, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29366313/laparoscopic-repair-of-perforated-peptic-ulcer-review
#8
Varcus Flore, Paun Ion, Duta Ciprian, Dobrescu Amadeus, Frandes Mirela, Tarta Cristi
BACKGROUND: Perforations of the peptic ulcers are the most common cause of emergency surgery among the complications of the gastroduodenal ulcers and the leading cause for morbidity and mortality due to secondary peritonitis and sepsis. PPU is a condition in which laparoscopic perforation repair (LPR) is an optimal solution. It makes possible the identification of the perforation's site and allows closure of the perforation and the subsequent peritoneal lavage, as in an open repair (OR) but without the large upper mid-abdominal incision...
January 23, 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29361710/influence-of-magnesium-ions-in-the-seawater-environment-on-the-improvement-of-the-corrosion-resistance-of-low-chromium-alloy-steel
#9
Sol-Ji Song, Jung-Gu Kim
This study examined the synergic effect of alloying the element Cr and the environmental element Mg2+ ions on the corrosion property of a low-alloy steel in seawater at 60 °C, by means of electrochemical impedance spectroscopy (EIS), linear polarization resistance (LPR) tests and weight-loss tests. The Mg2+ ions in seawater played an important role in lowering the electron transfer of the rust layer in the Cr-containing steel. The corrosion resistance of the Cr-containing steel is superior to that of blank steel in Mg2+ ions containing seawater...
January 20, 2018: Materials
https://www.readbyqxmd.com/read/29358664/delayed-onset-of-autoreactive-antibody-production-and-m2-skewed-macrophages-contribute-to-improved-survival-of-taci-deficient-mrl-fas-lpr-mouse
#10
Lunhua Liu, Windy Rose Allman, Adam Steven Coleman, Kazuyo Takeda, Tsai-Lien Lin, Mustafa Akkoyunlu
Anti-B cell activating factor belonging to TNF-family (BAFF) antibody therapy is indicated for the treatment of patients with active systemic lupus erythematosus (SLE). We hypothesized that the BAFF receptor, transmembrane activator and calcium-modulator and cyclophilin interactor (TACI) may be responsible for the generation of antibody secreting plasma cells in SLE. To test this hypothesis, we generated TACI deficient MRL-Fas/Lpr (LPR-TACI-/-) mouse. TACI deficiency resulted in improved survival of MRL-Fas/Lpr mice and delayed production of anti-dsDNA and anti-SAM/RNP antibodies...
January 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29357434/neuraminidase-activity-mediates-il-6-production-by-activated-lupus-prone-mesangial-cells
#11
Kamala Sundararaj, Jessalyn I Rodgers, Subathra Marimuthu, Leah J Siskind, Evelyn Bruner, Tamara K Nowling
The development of nephritis is a leading cause of morbidity and mortality in lupus patients. While the general pathophysiological progression of lupus nephritis is known, the molecular mediators and mechanisms are incompletely understood. Previously, we demonstrated that the glycosphingolipid catabolic pathway is elevated in the kidneys of MRL/lpr lupus mice and human lupus patients with nephritis. Specifically, the activity of neuraminidase (NEU) and expression of Neu1, an enzyme in the GSL catabolic pathway is significantly increased...
December 20, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29349990/-experimentation-of-the-relationship-between-medial-or-lateral-patellar-stabilizer-and-patellofemoral-stabilization
#12
Xing-Sen Liang, Zheng-Hong Yu, Yi-Kai Li, Ying-Ping Jiang, Xian-Wu Chen, Min Huang
OBJECTIVE: To study the contribution of medial or lateral stabilizer to the stability of the patella, to explore the function and effect of releasing the LPR clinically and to provide a biomechanical basis for the clinical treatment of patellar instability(PI). METHODS: The quadriceps femoris of 6 fresh human cadaver knees were loaded to simulate a normal condition of muscle strength. First the loading force was measured and recorded, which subluxated the patella with the different degrees of knee flexion...
April 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29331424/ultra-narrow-surface-lattice-resonances-in-plasmonic-metamaterial-arrays-for-biosensing-applications
#13
Artem Danilov, Gleb Tselikov, Fan Wu, Vasyl G Kravets, Igor Ozerov, Frederic Bedu, Alexander N Grigorenko, Andrei V Kabashin
When excited over a periodic metamaterial lattice of gold nanoparticles (~ 100nm), localized plasmon resonances (LPR) can be coupled by a diffraction wave propagating along the array plane, which leads to a drastic narrowing of plasmon resonance lineshapes (down to a few nm full-width-at-half-maximum) and the generation of singularities of phase of reflected light. These phenomena look very promising for the improvement of performance of plasmonic biosensors, but conditions of implementation of such diffractively coupled plasmonic resonances, also referred to as plasmonic surface lattice resonances (PSLR), are not always compatible with biosensing arrangement implying the placement of the nanoparticles between a glass substrate and a sample medium (air, water)...
December 9, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29327685/the-role-of-pepsin-in-the-laryngopharyngeal-reflux
#14
Katarzyna Kowalik, Antoni Krzeski
Laryngopharyngeal reflux (LPR) is a common defect among laryngological and phoniatric patients. Although LPR is categorized as a superficial gastroesophageal reflux disease (GERD), differential diagnosis should treat these two diseases separately. LPR symptoms can be assessed in the interview using as a tool the reflux symptom index (RSI). In addition, changes in the larynx that occur during LPR might be seen during laryngoscopy and classified according to the reflux finding score (RFS). One of the main mucosal irritants in LPR is pepsin which digests proteins and impairs the functions of the upper respiratory tract cells by affecting carbonate anhydrase (CAIII) and the Sep 70 protein...
December 30, 2017: Otolaryngologia Polska
https://www.readbyqxmd.com/read/29294839/blame-attributions-in-multiple-perpetrator-rape-cases-the-impact-of-sympathy-consent-force-and-beliefs
#15
Kerstin Adolfsson, Leif A Strömwall, Sara Landström
Victims of multiple perpetrator rape (MPR) have been found to be an especially vulnerable group. This study examined effects of MPR and perpetrators' use of force on attributions of victim and perpetrator blame. In two large experiments (total N = 2,928), Swedish community members read scenarios depicting an MPR and subsequently made several ratings of blame, rape myth acceptance (RMA), just world beliefs, sympathy for the victim, perception of consent, and trust in the legal system. Data were analyzed with a multianalytical approach using both analyses of variance as well as exploratory analyses...
July 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29277812/association-between-laryngopharyngeal-reflux-and-radiation-induced-mucositis-in-head-and-neck-cancer
#16
Kohtaro Eguchi, Masami Suzuki, Shota Ida, Keita Mori, Hisao Imai, Shigehiro Kudo, Ken Ando, Keiko Higuchi, Takeshi Ebara
BACKGROUND/AIM: We investigated whether laryngopharyngeal reflux (LPR) is a risk factor for radiation-induced mucositis. PATIENTS AND METHODS: This was a retrospective cohort study using our departmental database. The study included patients with stage I or II laryngeal and hypopharyngeal cancers treated with radiation therapy alone between April 2009 and March 2014. Based on endoscopic findings, baseline laryngeal signs were evaluated using the reflux finding score (RFS), and the severity of mucositis was assessed during and after radiation therapy...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29273884/one-decade-of-rectal-prolapse-surgery-a-national-study
#17
Trine Bjerke, Tommie Mynster
PURPOSE: We aimed to investigate the development of common procedures used as treatment for rectal prolapse over a decade and to determine if the choice of primary operation affects the reoperation rate. METHODS: This is a retrospective analysis of operative data from a National Data Registry, Landspatientregisteret (LPR), from the period of January 1, 2004 to December 31, 2014. All hospitalized surgical treatments are registered in LPR. RESULTS: Sixteen hundred and twenty-five patients with rectal prolapse underwent 1834 operations...
December 23, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29250557/stabilized-%C3%AE-catenin-ameliorates-alps-like-symptoms-of-b6-lpr-mice
#18
Xiaoxie Xu, Jun Huang, Mei Zhao, Huanpeng Chen, Jinhua Mo, Xiaoqing Zhou, Qiao Su, Bolan Yu, Zhaofeng Huang
Autoimmune lymphoproliferative syndrome (ALPS) is an incurable disease mainly caused by the defect of Fas-mediated apoptosis and characterized by nonmalignant autoimmune lymphoproliferation. Stabilized β-catenin could not only potentiate Fas-mediated T cell apoptosis via upregulating the expression of Fas on activated T cells, but also potentiate T cell apoptosis via intrinsic apoptotic pathway. In the present study, we introduced β-catTg into lpr/lpr mice and aimed to explore the potential role of stabilized β-catenin (β-catTg) in the development of ALPS-like phenotypes of lpr/lpr mice...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/29246392/image-analysis-of-interarytenoid-area-to-detect-cases-of-laryngopharyngeal-reflux-an-objective-method
#19
Anindya Nayak, Sunil Kumar, Rubeena Arora, Gautam Bir Singh
PURPOSE: To diagnose Laryngopharyngeal Reflux by observing colour (Red, Green, Blue) at the interarytenoid area during 70° laryngeal endoscopy. MATERIALS AND METHODS: Endoscopic images from 50 normal controls and 50 patients of LPR were obtained in this observational study. LPR patients were selected on the basis of RSI and RFS. Images were analysed using ImageJ, a free image analysis software, developed by the National Institute of Health (NIH). Colour changes in the form of RGB (red, green, blue) values were calculated and analysed at the interarytenoid area...
November 28, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29238875/pepsin-in-saliva-as-a-diagnostic-biomarker-in-laryngopharyngeal-reflux-a-meta-analysis
#20
REVIEW
Jing Wang, Yu Zhao, Jianjun Ren, Yang Xu
OBJECTIVE: Pepsin in saliva has been proposed as a biomarker for the diagnosis of laryngopharyngeal reflux (LPR), but the results remain controversial. We assessed the diagnostic value of pepsin in saliva for LPR. METHODS: PubMed, Embase, and Web of Science were searched for studies in English that evaluated the utility of pepsin in saliva in the diagnosis of LPR, published up to 15 March 2017. We used Stata 12.0 to summarize the diagnostic indexes for the meta-analysis...
December 13, 2017: European Archives of Oto-rhino-laryngology
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