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https://www.readbyqxmd.com/read/29667372/long-working-hours-and-skipping-breakfast-concomitant-with-late-evening-meals-are-associated-with-suboptimal-glycemic-control-among-young-male-japanese-patients-with-type-2-diabetes
#1
Yasushi Azami, Mitsuhiko Funakoshi, Hisashi Matsumoto, Akemi Ikota, Koichi Ito, Hisashi Okimoto, Nobuaki Shimizu, Fumihiro Tsujimura, Hiroshi Fukuda, Chozi Miyagi, Sayaka Osawa, Ryo Osawa, Jiro Miura
AIMS/INTRODUCTION: To assess the associations or working conditions, eating habits, and glycemic control among young Japanese workers with type 2 diabetes. MATERIALS AND METHODS: This hospital- and clinic-based prospective study included 352 male and 126 female working patients with diabetes aged 20-40 years. Data were obtained from June to July 2012 and June to July 2013. Logistic regression analysis was used to estimate multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for suboptimal glycemic control (HbAlc level of ≥7%) obtained from June to July 2013...
April 17, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29665733/natural-history-predictors-of-outcome-and-effects-of-treatment-in-thoracic-spinal-cord-injury-a-multicenter-cohort-study-from-the-north-american-clinical-trials-network
#2
Jefferson R Wilson, Blessing Jaja, Brian K Kwon, James Guest, James Shields Harrop, Bizhan Aarabi, Christopher Shaffrey, Jetan Badhiwala, Elizabeth Toups, Robert Grossman, Michael G Fehlings
The course, treatment response and recovery potential following acute traumatic spinal cord injury (SCI) have been shown to differ depending on the neurological level of injury. However, there are limited data focused on thoracic-level injuries. A cohort of 86 patients from the prospectively maintained North American Clinical Trials Network (NACTN) SCI registry were identified and studied to characterize the patterns of neurological recovery as well as to determine rates of acute hospital mortality and pulmonary complications...
April 18, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29664852/lower-extremity-motor-function-following-complex-adult-spinal-deformity-surgery-two-year-follow-up-in-the-scoli-risk-1-prospective-multicenter-international-study
#3
Lawrence G Lenke, Christopher I Shaffrey, Leah Y Carreon, Kenneth M C Cheung, Benny T Dahl, Michael G Fehlings, Christopher P Ames, Oheneba Boachie-Adjei, Mark B Dekutoski, Khaled M Kebaish, Stephen J Lewis, Yukihiro Matsuyama, Hossein Mehdian, Ferran Pellisé, Yong Qiu, Frank J Schwab
BACKGROUND: The reported neurologic complication rate following surgery for complex adult spinal deformity (ASD) is variable due to several factors. Most series have been retrospective with heterogeneous patient populations and use of nonuniform neurologic assessments. The aim of this study was to prospectively document lower extremity motor function by means of the American Spinal Injury Association (ASIA) lower extremity motor score (LEMS) before and through 2 years after surgical correction of complex ASD...
April 18, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29655456/lambert-eaton-myasthenic-syndrome
#4
REVIEW
Vita G Kesner, Shin J Oh, Mazen M Dimachkie, Richard J Barohn
Lambert-Eaton myasthenic syndrome is a paraneoplastic or primary autoimmune neuromuscular junction disorder characterized by proximal weakness, autonomic dysfunction and ariflexia. The characteristic symptoms are thought to be caused by antibodies generated against the P/Q-type voltage-gated calcium channels present on presynaptic nerve terminals and by diminished release of acetylcholine. More than half of Lambert-Eaton myasthenic syndrome cases are associated with small cell lung carcinoma. Diagnosis is confirmed by serologic testing and electrophysiologic studies...
May 2018: Neurologic Clinics
https://www.readbyqxmd.com/read/29651661/high-arctic-lemmings-remain-reproductively-active-under-predator-induced-elevated-stress
#5
Dominique Fauteux, Gilles Gauthier, Dominique Berteaux, Rupert Palme, Rudy Boonstra
Non-consumptive effects of predation have rarely been assessed in wildlife populations even though their impact could be as important as lethal effects. Reproduction of individuals is one of the most important demographic parameters that could be affected by predator-induced stress, which in turn can have important consequences on population dynamics. We studied non-consumptive effects of predation on the reproductive activity (i.e., mating and fertilization) of a cyclic population of brown lemmings exposed to intense summer predation in the Canadian High Arctic...
April 12, 2018: Oecologia
https://www.readbyqxmd.com/read/29650628/liberation-from-the-p-value-s-tyranny
#6
Lem Moyé, Michelle Cohen
No abstract text is available yet for this article.
April 13, 2018: Circulation Research
https://www.readbyqxmd.com/read/29626102/identification-of-unusual-oxysterols-and-bile-acids-with-7-oxo-or-3%C3%AE-5%C3%AE-6%C3%AE-trihydroxy-functions-in-human-plasma-by-charge-tagging-mass-spectrometry-with-multistage-fragmentation
#7
William J Griffiths, Ian Gilmore, Eylan Yutuc, Jonas Abdel-Khalik, Peter J Crick, Thomas Hearn, Alison Dickson, Brian W Bigger, Teresa Hoi-Yee Wu, Anu Goenka, Arunabha Ghosh, Simon A Jones, Yuqin Wang
7-Oxocholesterol (7-OC), 5,6-epoxycholesterol (5,6-EC) and its hydrolysis product cholestane-3β,5α,6β-triol (3β,5α,6β-triol) are normally minor oxysterols in human samples, however, in disease their levels may be greatly elevated. This is the case in plasma from patients suffering from some lysosomal storage disorders e.g. Niemann Pick disease type C, or the inborn errors of sterol metabolism e.g. Smith-Lemli-Opitz syndrome and cerebrotendinous xanthomatosis. A complication in the analysis of 7-OC and 5,6-EC is that they can also be formed ex vivo from cholesterol during sample handling in air causing confusion with molecules formed in vivo...
April 6, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29623569/advances-in-computer-assisted-syndrome-recognition-by-the-example-of-inborn-errors-of-metabolism
#8
Jean T Pantel, Max Zhao, Martin A Mensah, Nurulhuda Hajjir, Tzung-Chien Hsieh, Yair Hanani, Nicole Fleischer, Tom Kamphans, Stefan Mundlos, Yaron Gurovich, Peter M Krawitz
Significant improvements in automated image analysis have been achieved in recent years and tools are now increasingly being used in computer-assisted syndromology. However, the ability to recognize a syndromic facial gestalt might depend on the syndrome and may also be confounded by severity of phenotype, size of available training sets, ethnicity, age, and sex. Therefore, benchmarking and comparing the performance of deep-learned classification processes is inherently difficult. For a systematic analysis of these influencing factors we chose the lysosomal storage diseases mucolipidosis as well as mucopolysaccharidosis type I and II that are known for their wide and overlapping phenotypic spectra...
April 5, 2018: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29617178/recruitment-of-feces-donors-among-blood-donors-results-from-an-observational-cohort-study
#9
Simon Mark Dahl Jørgensen, Christian Erikstrup, Khoa Manh Dinh, Lars Erik Lemming, Jens Frederik Dahlerup, Christian Lodberg Hvas
As the use of fecal microbiota transplantation (FMT) has gained momentum, an increasing need for continuous access to healthy feces donors has developed. Blood donors constitute a healthy subset of the general population and may serve as an appropriate group for recruitment. In this study, we investigated the suitability of blood donors as feces donors. In a prospective cohort study, we recruited blood donors onsite at a public Danish blood bank. Following their consent, the blood donors underwent a stepwise screening process: First, blood donors completed an electronic pre-screening questionnaire to rule out predisposing risk factors...
April 4, 2018: Gut Microbes
https://www.readbyqxmd.com/read/29605379/bacteriology-of-the-buttonhole-cannulation-tract-in-hemodialysis-patients-a-prospective-cohort-study
#10
Line Dahlstrøm Christensen, Mai-Britt Skadborg, Agnete H Mortensen, Carsten Mortensen, Jens K Møller, Lars Lemming, Irene Høgsberg, Steffen E Petersen, Niels H Buus
BACKGROUND: The buttonhole cannulation technique for arteriovenous fistulas is widely used, but has been associated with an increased rate of vascular access-related infections. We describe the frequency and type of bacterial colonization of the buttonhole tract over time and associated clinical infections. STUDY DESIGN: A prospective observational cohort study with 9 months of follow-up. SETTING & PARTICIPANTS: 84 in-center hemodialysis patients using the buttonhole cannulation technique at 2 Danish dialysis centers...
March 29, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29595516/a-rare-cause-of-congenital-adrenal-hyperplasia-clinical-and-genetic-findings-and-follow-up-characteristics-of-six-patients-with-17-hydroxylase-deficiency-and-two-novel-mutations
#11
Aslı Derya Kardelen, Güven Toksoy, Firdevs Baş, Zehra Yavaş Abalı, Genco Gençay, Şükran Poyrazoğlu, Rüveyde Bundak, Umut Altunoğlu, Şahin Avcı, Adam Najaflı, Oya Uyguner, Birsen Karaman, Seher Başaran, Feyza Darendeliler
BACKGROUND: 17-α-hydroxylase/17,20 lyase deficiency (17OHD) is a rare form of congenital adrenal hyperplasia (CAH), characterized by hypertension and varying degrees of ambiguous genitalia and delayed pu-berty. The disease is associated with bi-allelic mutations in the CYP17A1 gene located on chromosome 10q24.3. We aimed to present clinical and genetic findings and follow-up and treatment of 17-OHD patients. PATIENTS AND METHODS: We evaluated six patients with 17OHD from five families at presentation and at follow up...
March 29, 2018: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29569544/a-comparison-between-two-healthy-diet-scores-the-modified-mediterranean-diet-score-and-the-healthy-nordic-food-index-in-relation-to-all-cause-and-cause-specific-mortality
#12
Eva Warensjö Lemming, Liisa Byberg, Alicja Wolk, Karl Michaëlsson
High adherence to healthy diets has the potential to prevent disease and prolong life span, and healthy dietary pattern scores have each been associated with disease and mortality. We studied two commonly promoted healthy diet scores (modified Mediterranean diet score (mMED) and the Healthy Nordic Food Index (HNFI)) and the combined effect of the two scores in association with all-cause and cause-specific mortality (cancer, CVD and ischaemic heart disease). The study included 38 428 women (median age of 61 years) from the Swedish Mammography Cohort...
April 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29565986/an-unfavorable-body-composition-is-common-in-early-arthritis-patients-a-case-control-study
#13
Samina A Turk, Dirkjan van Schaardenburg, Maarten Boers, Sylvia de Boer, Cindy Fokker, Willem F Lems, Michael T Nurmohamed
BACKGROUND: An unfavorable body composition is often present in chronic arthritis patients. This unfavorable composition is a loss of muscle mass, with a stable or increased (abdominal) fat mass. Since it is unknown when this unfavorable composition develops, we compared body composition in disease-modifying antirheumatic drugs (DMARD)-naive early arthritis patients with non-arthritis controls and explored the association, in early arthritis patients, with disease activity and traditional cardiovascular risk factors...
2018: PloS One
https://www.readbyqxmd.com/read/29563267/population-cycles-generalities-exceptions-and-remaining-mysteries
#14
REVIEW
Judith H Myers
Population cycles are one of nature's great mysteries. For almost a hundred years, innumerable studies have probed the causes of cyclic dynamics in snowshoe hares, voles and lemmings, forest Lepidoptera and grouse. Even though cyclic species have very different life histories, similarities in mechanisms related to their dynamics are apparent. In addition to high reproductive rates and density-related mortality from predators, pathogens or parasitoids, other characteristics include transgenerational reduced reproduction and dispersal with increasing-peak densities, and genetic similarity among populations...
March 28, 2018: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29556414/exoskeleton-assisted-gait-training-to-improve-gait-in-individuals-with-spinal-cord-injury-a-pilot-randomized-study
#15
Shuo-Hsiu Chang, Taimoor Afzal, Jeffrey Berliner, Gerard E Francisco
Background: Robotic wearable exoskeletons have been utilized as a gait training device in persons with spinal cord injury. This pilot study investigated the feasibility of offering exoskeleton-assisted gait training (EGT) on gait in individuals with incomplete spinal cord injury (iSCI) in preparation for a phase III RCT. The objective was to assess treatment reliability and potential efficacy of EGT and conventional physical therapy (CPT). Methods: Forty-four individuals were screened, and 13 were eligible to participate in the study...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29546908/molecular-lemmings-strategies-to-avoid-when-designing-bodipy-ferrocene-dyads-for-dye-sensitized-solar-cell-applications
#16
B A Hussein, J T Huynh, P L Prieto, C P Barran, A E Arnold, O V Sarycheva, A J Lough, B D Koivisto
BODIPY (4,4-difluoro-4-bora-3a,4a-diaza-s-indacenes) dyes possess intense absorption profiles that can be exploited in various light harvesting applications. However, redox stability and optimization of frontier molecular orbital energies in these dyes are critical for their successful incorporation into new solar cell materials. This article describes the synthesis and characterization of a family of β-substituted BODIPY-ferrocene dyads with push-pull architectures. Designed to stabilize the photo-oxidized BODIPY for dye-sensitized solar cell (DSSC) applications, some deleterious electron transfer behaviours emerged when the ferrocene unit was conjugated to electron deficient BODIPYs...
March 16, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29537391/-survival-a-simulation-toolkit-introducing-a-modular-approach-for-radiobiological-evaluations-in-ion-beam-therapy
#17
Lorenzo Manganaro, Germano Russo, Faiza Bourhaleb, Federico Fausti, Simona Giordanengo, Vincenzo Monaco, Roberto Sacchi, Anna Vignati, Roberto Cirio, Andrea Attili
One major rationale for the application of heavy ion beams in tumour therapy is their increased relative biological effectiveness (RBE). The complex dependencies of the RBE on dose, biological endpoint, position in the field etc. require the use of biophysical models in treatment planning and clinical analysis. This study aims at introducing a new software, named "Survival", to facilitate the radiobiological computations needed in ion therapy. The simulation toolkit was written in C++ and it was developed with a modular architecture in order to easily incorporate different radiobiological models...
March 14, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29533037/-clinical-effects-of-high-frequency-repeated-transcranial-magnetic-stimulation-therapy-on-dyskinesia-in-patients-with-incomplete-spinal-cord-injury-a-meta-analysis
#18
Zheng-Chao Gao, Bin-Bin Niu, Meng-Chao Gu, Yu-Huan Li, Jian-Tao Liu, Yi-Bin Wang, Xi-Jing He
OBJECTIVE: To systematically evaluate the clinical effect of high frequency repeated transcranial magnetic stimulation(HF rTMS)therapy on dyskinesia in patients with incomplete spinal cord injury. METHODS: Randomized controlled trials(RCTs) about HF rTMS therapy on patients with motor incomplete spinal cord injury were searched electronically in PubMed, Google scholar, Cochrane library, Clinical trial, Medline, Web of science, CNKI, VIP, and Wanfang database before October 2016...
January 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29526952/lambert-eaton-myasthenic-syndrome-associated-with-synchronous-double-cancer-a-combination-of-small-cell-carcinoma-of-the-cervix-and-breast-carcinoma
#19
Hiroyuki Fukuda, Akira Tanaka, Yasuyuki Hirashima, Ichiro Ito
Lambert-Eaton myasthenic syndrome (LEMS) is most commonly associated with small cell lung carcinoma, while it is rarely associated with gynecological and breast carcinoma. We herein report a case of LEMS associated with synchronous double cancer, which was a combination of small cell carcinoma of the cervix and breast carcinoma. The early diagnosis and treatment of LEMS are important for achieving a good outcome. The possibility of accompanying paraneoplastic neurological syndrome must be sufficiently considered in gynecology and breast cancer patients...
March 9, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29520709/direct-analysis-of-proteins-from-solutions-with-high-salt-concentration-using-laser-electrospray-mass-spectrometry
#20
Santosh Karki, Fengjian Shi, Jieutonne J Archer, Habiballah Sistani, Robert J Levis
The detection of lysozyme, or a mixture of lysozyme, cytochrome c, and myoglobin, from solutions with varying salt concentrations (0.1 to 250 mM NaCl) is compared using laser electrospray mass spectrometry (LEMS) and electrospray ionization-mass spectrometry (ESI-MS). Protonated protein peaks were observed up to a concentration of 250 mM NaCl in the case of LEMS. In the case of ESI-MS, a protein solution with salt concentration > 0.5 mM resulted in predominantly salt-adducted features, with suppression of the protonated protein ions...
March 8, 2018: Journal of the American Society for Mass Spectrometry
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