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https://www.readbyqxmd.com/read/29035574/a-6-month-open-label-extension-study-of-vortioxetine-in-pediatric-patients-with-depressive-or-anxiety-disorders
#1
Robert L Findling, Adelaide S Robb, Melissa P DelBello, Michael Huss, Nora K McNamara, Elias H Sarkis, Russell E Scheffer, Lis H Poulsen, Grace Chen, Ole M Lemming, Philippe Auby
OBJECTIVES: In this 6-month open-label extension (OLE) of NCT01491035 (a 14-day, open-label, pharmacokinetic/safety lead-in study), the long-term safety and tolerability of vortioxetine (5-20 mg/day) were investigated in children and adolescents with a DSM-IV-TR™ diagnosis of depressive or anxiety disorder in the United States or Germany. The study also was designed to provide data to inform dose selection and titration in future pediatric studies with vortioxetine. METHODS: Safety evaluations included spontaneously reported adverse events (AEs), the Columbia Suicide Severity Rating Scale (C-SSRS), and the Pediatric Adverse Events Rating Scale (PAERS; clinician administered)...
October 16, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29026325/laparoscopic-esophageal-myotomy-versus-pneumatic-dilation-in-the-treatment-of-idiopathic-achalasia-a-meta-analysis-of-randomized-controlled-trials
#2
Ramkaji Baniya, Sunil Upadhaya, Jahangir Khan, Suresh Kumar Subedi, Tabrez Shaik Mohammed, Balvant K Ganatra, Ghassan Bachuwa
BACKGROUND: Achalasia is a primary esophageal motility disorder of unknown etiology associated with abnormalities in peristalsis and lower esophageal sphincter relaxation. The disease is incurable; however, definitive treatment procedures like pneumatic dilation (PD)/balloon dilation and laparoscopic esophageal myotomy (LEM) are performed to relieve dysphagia and related symptoms. Currently, there is paucity of data comparing the outcomes of these procedures. The aim of this meta-analysis is to compare the short- and long-term success rates of PD and LEM...
2017: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/28990874/intensive-gait-treatment-using-a-robot-suit-hybrid-assistive-limb-in-acute-spinal-cord-infarction-report-of-two-cases
#3
Hiroki Watanabe, Aiki Marushima, Hiroaki Kawamoto, Hideki Kadone, Tomoyuki Ueno, Yukiyo Shimizu, Ayumu Endo, Yasushi Hada, Kousaku Saotome, Tetsuya Abe, Masashi Yamazaki, Yoshiyuki Sankai, Eiichi Ishikawa, Akira Matsumura
CONTEXT: Spinal cord infarction (SCI) causes gait disturbance because of paresis, spasticity, and sensory disturbance of the lower limbs. There is no effective medical treatment for SCI, and conventional rehabilitation alone is the main approach to helping individuals work toward independent walking. The aim of this study was to evaluate the effect of gait treatment using the Hybrid Assistive Limb (HAL) on acute SCI. FINDINGS: A 61-year-old female and a 62-year-old male with incomplete paraplegia participated in this study...
October 9, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28972544/assessing-monkeypox-virus-prevalence-in-small-mammals-at-the-human-animal-interface-in-the-democratic-republic-of-the-congo
#4
Jeffrey B Doty, Jean M Malekani, Lem's N Kalemba, William T Stanley, Benjamin P Monroe, Yoshinori U Nakazawa, Matthew R Mauldin, Trésor L Bakambana, Tobit Liyandja Dja Liyandja, Zachary H Braden, Ryan M Wallace, Divin V Malekani, Andrea M McCollum, Nadia Gallardo-Romero, Ashley Kondas, A Townsend Peterson, Jorge E Osorio, Tonie E Rocke, Kevin L Karem, Ginny L Emerson, Darin S Carroll
During 2012, 2013 and 2015, we collected small mammals within 25 km of the town of Boende in Tshuapa Province, the Democratic Republic of the Congo. The prevalence of monkeypox virus (MPXV) in this area is unknown; however, cases of human infection were previously confirmed near these collection sites. Samples were collected from 353 mammals (rodents, shrews, pangolins, elephant shrews, a potamogale, and a hyrax). Some rodents and shrews were captured from houses where human monkeypox cases have recently been identified, but most were trapped in forests and agricultural areas near villages...
October 3, 2017: Viruses
https://www.readbyqxmd.com/read/28972118/vulnerability-of-dhcr7-mutation-carriers-to-aripiprazole-and-trazodone-exposure
#5
Zeljka Korade, Thiago C Genaro-Mattos, Keri A Tallman, Wei Liu, Krassimira A Garbett, Katalin Koczok, Istvan Balogh, Karoly Mirnics, Ned A Porter
Smith-Lemli-Opitz syndrome is a recessive disorder caused by mutations in 7-dehyrocholesterol reductase (DHCR7) with a heterozygous carrier frequency of 1-3%. A defective DHCR7 causes accumulation of 7-DHC, which is a highly oxidizable and toxic compound. Recent studies suggest that several antipsychotics, including the highly-prescribed pharmaceuticals aripiprazole (ARI) and trazodone (TRZ), increase 7-DHC levels in vitro and in humans. Our investigation was designed to compare the effects of ARI and TRZ on cholesterol synthesis in fibroblasts from DHCR7+/- human carriers and controls...
September 28, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28951771/uplc-ms-ms-profile-of-alkaloids-with-cytotoxic-properties-of-selected-medicinal-plants-of-the-berberidaceae-and-papaveraceae-families
#6
Anna Och, Katarzyna Szewczyk, Łukasz Pecio, Anna Stochmal, Daniel Załuski, Anna Bogucka-Kocka
Cancer is one of the most occurring diseases in developed and developing countries. Plant-based compounds are still researched for their anticancer activity and for their quantity in plants. Therefore, the modern chromatographic methods are applied to quantify them in plants, for example, UPLC-MS/MS (ultraperformance liquid chromatography tandem mass spectrometry). Therefore, the aim of the present study was to evaluate the content of sanguinarine, berberine, protopine, and chelidonine in Dicentra spectabilis (L...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28946192/phytochemical-characterization-and-bioactivity-of-lycium-europaeum-a-focus-on-antioxidant-antinociceptive-hepatoprotective-and-nephroprotective-effects
#7
Ilhem Rjeibi, Anouar Feriani, Anouar Ben Saad, Sana Ncib, Jazia Sdayria, Issam Saidi, Sami Souid, Najla Hfaiedh, Mohamed Salah Allagui
In this study, the antioxidant, antinociceptive, hepatoprotective, nephroprotective properties and the bioactive composition of Lycium europaeum were investigated. Polyphenols and total tannin contents were measured by colorimetric methods The antioxidant activity in vitro was evaluated using the reducing power, 2,2-diphenyl-1-picrylhydrazyl radical and phosphomolybdenum assays. The hepatotoxicity and nephrotoxicity effects were studied using carbon tetrachloride (CCl4)-induced liver and renal injuries in mice...
September 19, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28929165/proprioception-mediates-the-association-between-systemic-inflammation-and-muscle-weakness-in-patients-with-knee-osteoarthritis-results-from-the-amsterdam-osteoarthritis-cohort
#8
Tomasz Cudejko, Martin van der Esch, Marike van der Leeden, Jasmijn Holla, Leo D Roorda, Willem Lems, Joost Dekker
OBJECTIVES: To determine whether systemic inflammation is associated with poor proprioception; to confirm that systemic inflammation is associated with muscle weakness; and to determine whether poor proprioception mediates the association between systemic inflammation and muscle weakness in knee osteoarthritis. DESIGN: Cross-sectional study. SUBJECTS: A total of 689 participants with knee osteoarthritis from the Amsterdam Osteoarthritis (AMS-OA) cohort...
September 20, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28927869/what-have-we-learned-from-best
#9
Cornelia F Allaart, Iris M Markusse, Willem F Lems
BACKGROUND: How have the long term outcomes of RA improved in the last decade? METHODS: Patients with DMARD naïve RA were randomized to 4 treatment strategies: 1. sequential DMARD monotherapy, 2. step-up combination therapy, 3. initial combination therapy including prednisone or 4. including infliximab. Treatment-to-target was aimed at DAS≤2.4 (three-monthly calculations). Functional ability (HAQ), radiologic damage progression (Sharp/vanderHeijde Score) and overall survival were reported...
September 16, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28919842/international-society-of-sports-nutrition-position-stand-nutrient-timing
#10
REVIEW
Chad M Kerksick, Shawn Arent, Brad J Schoenfeld, Jeffrey R Stout, Bill Campbell, Colin D Wilborn, Lem Taylor, Doug Kalman, Abbie E Smith-Ryan, Richard B Kreider, Darryn Willoughby, Paul J Arciero, Trisha A VanDusseldorp, Michael J Ormsbee, Robert Wildman, Mike Greenwood, Tim N Ziegenfuss, Alan A Aragon, Jose Antonio
The International Society of Sports Nutrition (ISSN) provides an objective and critical review regarding the timing of macronutrients in reference to healthy, exercising adults and in particular highly trained individuals on exercise performance and body composition. The following points summarize the position of the ISSN:Nutrient timing incorporates the use of methodical planning and eating of whole foods, fortified foods and dietary supplements. The timing of energy intake and the ratio of certain ingested macronutrients may enhance recovery and tissue repair, augment muscle protein synthesis (MPS), and improve mood states following high-volume or intense exercise...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28916915/inflammatory-diseases-and-bone-fragility
#11
REVIEW
K Briot, P Geusens, I Em Bultink, W F Lems, C Roux
Systemic osteoporosis and increased fracture rates have been described in chronic inflammatory diseases such as rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, inflammatory bowel diseases, and chronic obstructive pulmonary disease. Most of these patients receive glucocorticoids, which have their own deleterious effects on bone. However, the other main determinant of bone fragility is the inflammation itself, as shown by the interactions between the inflammatory mediators, the actors of the immune system, and the bone remodelling...
September 15, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28915877/vole-abundance-and-reindeer-carcasses-determine-breeding-activity-of-arctic-foxes-in-low-arctic-yamal-russia
#12
Dorothee Ehrich, Maite Cerezo, Anna Y Rodnikova, Natalya A Sokolova, Eva Fuglei, Victor G Shtro, Aleksandr A Sokolov
BACKGROUND: High latitude ecosystems are at present changing rapidly under the influence of climate warming, and specialized Arctic species at the southern margin of the Arctic may be particularly affected. The Arctic fox (Vulpes lagopus), a small mammalian predator endemic to northern tundra areas, is able to exploit different resources in the context of varying tundra ecosystems. Although generally widespread, it is critically endangered in subarctic Fennoscandia, where a fading out of the characteristic lemming cycles and competition with abundant red foxes have been identified as main threats...
September 16, 2017: BMC Ecology
https://www.readbyqxmd.com/read/28899285/predicting-rehabilitation-length-of-stay-in-canada-it-s-not-just-about-impairment
#13
B Catharine Craven, Dilnur Kurban, Farnoosh Farahani, Carly S Rivers, Chester Ho, A Gary Linassi, Dany H Gagnon, Colleen O'Connell, Karen Ethans, Laurent J Bouyer, Vanessa K Noonan
INTRODUCTION: Current tertiary Spinal Cord Injury (SCI) rehabilitation funding and rehabilitation length of stay (R-LOS) in most North American jurisdictions are linked to an individual's impairment. Our objectives were to: 1) describe the impact of relevant demographic, impairment and medical complexity variables at rehabilitation admission on R-LOS among adult Canadians with traumatic SCI; and 2) identify factors which extend R-LOS. METHODS: Data from 1,376 adults with traumatic SCI were obtained via chart abstraction and administrative data linkage from 15 Rick Hansen SCI Registry sites (2004-2014)...
September 12, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28891864/photosensitization-of-trpa1-and-trpv1-by-7-dehydrocholesterol-implications-for-the-smith-lemli-opitz-syndrome
#14
Alexandru Babes, Cosmin I Ciotu, Tal Hoffmann, Tatjana I Kichko, Tudor Selescu, Cristian Neacsu, Susanne K Sauer, Peter W Reeh, Michael J M Fischer
Loss-of-function mutations in the enzyme 7-dehydrocholesterol reductase are responsible for the Smith-Lemli-Opitz syndrome, in which 7-dehydrocholesterol (7-DHC) levels are markedly increased in the plasma and tissues of patients. This increase in 7-DHC is probably associated with the painful and itchy photosensitivity reported by the majority of patients with Smith-Lemli-Opitz syndrome. To identify the molecular targets involved in the activation and photosensitization of primary afferents by 7-DHC, we focused on TRPA1 and TRPV1, two ion channels expressed in nociceptive nerve endings and previously shown to respond to ultraviolet and visible light under pathophysiological circumstances...
September 1, 2017: Pain
https://www.readbyqxmd.com/read/28887233/methotrexate-pharmacogenetics-in-uruguayan-adults-with-hematological-malignant-diseases
#15
Andrea Giletti, Marcelo Vital, Mariana Lorenzo, Patricia Cardozo, Gabriel Borelli, Raúl Gabus, Lem Martínez, Lilian Díaz, Rodrigo Assar, María Noel Rodriguez, Patricia Esperón
BACKGROUND: Individual variability is among the causes of toxicity and interruption of treatment in acute lymphoblastic leukemia (ALL) and severe non-Hodgkin lymphoma (NHL) patients under protocols including Methotrexate (MTX): 2,4-diamino-N10-methyl propyl-glutamic acid. METHODS: 41 Uruguayan patients were recruited. Gene polymorphisms involved in MTX pathway were analyzed and their association with treatment toxicities and outcome was evaluated. RESULTS: Genotype distribution and allele frequency were determined for SLC19A1 G80A, MTHFR C677T and A1298C, TYMS 28bp copy number variation, SLCO1B1 T521C, DHFR C-1610G/T, DHFR C-680A, DHFR A-317G and DHFR 19bp indel...
September 5, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28863820/sterol-regulation-of-voltage-gated-k-channels
#16
Andras Balajthy, Peter Hajdu, Gyorgy Panyi, Zoltan Varga
Cholesterol is an essential lipid building block of the cellular plasma membrane. In addition to its structural role, it regulates the fluidity and raft structure of the membrane and influences the course of numerous membrane-linked signaling pathways and the function of transmembrane proteins, including ion channels. This is supported by a vast body of scientific data, which demonstrates the modulation of ion channels with a great variety of ion selectivity, gating, and tissue distribution by changes in membrane cholesterol...
2017: Current Topics in Membranes
https://www.readbyqxmd.com/read/28859326/similar-efficacy-and-safety-of-initial-cobra-light-and-cobra-therapy-in-rheumatoid-arthritis-4-year-results-from-the-cobra-light-trial
#17
RANDOMIZED CONTROLLED TRIAL
Nicole P C Konijn, Lilian H D van Tuyl, Maarten Boers, Debby den Uyl, Marieke M Ter Wee, Lindsey K M van der Wijden, Irene E M Bultink, Pit J S M Kerstens, Alexandre E Voskuyl, Dirkjan van Schaardenburg, Michael T Nurmohamed, Willem F Lems
Objective: To assess the efficacy and safety of initial COBRA-light vs COBRA therapy in RA patients after a 4-year follow-up period. Methods: In the COBRA-light trial, 162 consecutive patients with recent-onset RA were randomized to either COBRA-light (prednisolone and MTX) or COBRA therapy (prednisolone, MTX and SSZ) for 1 year. After 1 year, treatment was continued without protocol, and adjusted by the treating physician according to clinical judgement, preferably with a treat-to-target strategy...
September 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28851778/seroprevalence-of-hepatitis-c-virus-infection-in-cameroon-a-systematic-review-and-meta-analysis
#18
Jean Joel Bigna, Marie A Amougou, Serra Lem Asangbeh, Angeladine Malaha Kenne, Jobert Richie Nansseu
OBJECTIVE: Better knowledge of hepatitis C virus (HCV) seroprevalence at the national level can help to implement pertinent strategies to address the HCV-related burden. The aim of this paper was to estimate the seroprevalence of HCV infection in Cameroon. DESIGN: Systematic review and meta-analysis. PARTICIPANTS: People residing in Cameroon. DATA SOURCES: Electronic databases including PubMed/MEDLINE, AJOL, WHO-Afro Library, Africa Index Medicus, National Institute of Statistics and National AIDS Control Committee, Cameroon from 1 January 2000 to 15 December 2016 were searched...
August 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/28827792/characterization-of-monkeypox-virus-infection-in-african-rope-squirrels-funisciurus-sp
#19
Elizabeth A Falendysz, Juan G Lopera, Jeffrey B Doty, Yoshinori Nakazawa, Colleen Crill, Faye Lorenzsonn, Lem's N Kalemba, Monica D Ronderos, Andres Mejia, Jean M Malekani, Kevin Karem, Darin S Carroll, Jorge E Osorio, Tonie E Rocke
Monkeypox (MPX) is a zoonotic disease endemic in Central and West Africa and is caused by Monkeypox virus (MPXV), the most virulent Orthopoxvirus affecting humans since the eradication of Variola virus (VARV). Many aspects of the MPXV transmission cycle, including the natural host of the virus, remain unknown. African rope squirrels (Funisciurus spp.) are considered potential reservoirs of MPXV, as serosurveillance data in Central Africa has confirmed the circulation of the virus in these rodent species [1,2]...
August 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28821939/analgesic-use-in-patients-with-knee-and-or-hip-osteoarthritis-referred-to-an-outpatient-center-a-cross-sectional-study-within-the-amsterdam-osteoarthritis-cohort
#20
Jesper Knoop, Joyce van Tunen, Martin van der Esch, Leo D Roorda, Joost Dekker, Marike van der Leeden, Willem F Lems
Although analgesics are widely recommended in current guidelines, underuse and inadequate prescription of analgesics seem to result in suboptimal treatment effects in patients with knee and/or hip osteoarthritis (OA). This study aimed (i) to describe the use of analgesics; and (ii) to determine factors that are related to analgesic use in patients with knee and/or hip OA referred to an outpatient center. A cross-sectional study with data from 656 patients with knee and/or hip OA referred to an outpatient center (Amsterdam Osteoarthritis (AMS-OA) cohort) was conducted...
August 18, 2017: Rheumatology International
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