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https://www.readbyqxmd.com/read/27882430/identification-of-cardiovascular-risk-factors-associated-with-bone-marrow-cell-subsets-in-patients-with-stemi-a-biorepository-evaluation-from-the-cctrn-time-and-latetime-clinical-trials
#1
Ariadna Contreras, Aaron F Orozco, Micheline Resende, Robert C Schutt, Jay H Traverse, Timothy D Henry, Dejian Lai, John P Cooke, Roberto Bolli, Michelle L Cohen, Lem Moyé, Carl J Pepine, Phillip C Yang, Emerson C Perin, James T Willerson, Doris A Taylor
Autologous bone marrow mononuclear cell (BM-MNC) therapy for patients with ST-segment elevation myocardial infarction (STEMI) has produced inconsistent results, possibly due to BM-MNC product heterogeneity. Patient-specific cardiovascular risk factors (CRFs) may contribute to variations in BM-MNC composition. We sought to identify associations between BM-MNC subset frequencies and specific CRFs in STEMI patients. Bone marrow was collected from 191 STEMI patients enrolled in the CCTRN TIME and LateTIME trials...
January 2017: Basic Research in Cardiology
https://www.readbyqxmd.com/read/27870031/top-down-limitation-of-lemmings-revealed-by-experimental-reduction-of-predators
#2
Dominique Fauteux, Gilles Gauthier, Dominique Berteaux
It is generally recognized that delayed density-dependence is responsible for cyclic population dynamics. However, it is still uncertain whether a single factor can explain why some rodent populations fluctuate according to a 3-4 yr periodicity. There is increasing evidence that predation may play a role in lemming population cycles, although this effect may vary seasonally. To address this issue, we conducted an experiment where we built a large exclosure (9 ha) to protect brown lemmings (Lemmus trimucronatus) from avian and terrestrial predators...
November 2016: Ecology
https://www.readbyqxmd.com/read/27866187/a-pilot-study-examining-the-effects-of-8-week-whey-protein-versus-whey-protein-plus-creatine-supplementation-on-body-composition-and-performance-variables-in-resistance-trained-women
#3
Colin D Wilborn, Jordan J Outlaw, Petey W Mumford, Stacie L Urbina, Sara Hayward, Michael D Roberts, Lem W Taylor, Cliffa A Foster
AIMS: We performed a pilot study examining the effects of whey protein and creatine supplementation (PRO + CRE group) versus whey protein supplementation (PRO group) alone on body composition and performance variables in a limited number of resistance-trained women. METHODS: Seventeen resistance-trained women (21 ± 3 years, 64.7 ± 8.2 kg, 23.5 kg/m2, 26.6 ± 4.8% body fat, >6 months of training) performed a 4-day per week split-body resistance training program for 8 weeks...
November 19, 2016: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/27850606/968-nmba-vs-sedation-only-facilitated-emergent-intubation-impacts-on-post-eti-hypotension-and-mortality
#4
Dell Simmons, Madison Josey, Tatum Lemly, Randall Hale
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27848060/man1-restricts-bmp-signaling-during-synaptic-growth-in-drosophila
#5
Ulrike Laugks, Marie Hieke, Nicole Wagner
Bone morphogenic protein (BMP) signaling is crucial for coordinated synaptic growth and plasticity. Here, we show that the nuclear LEM-domain protein MAN1 is a negative regulator of synaptic growth at Drosophila larval and adult neuromuscular junctions (NMJs). Loss of MAN1 is associated with synaptic structural defects, including floating T-bars, membrane attachment defects, and accumulation of vesicles between perisynaptic membranes and membranes of the subsynaptic reticulum. In addition, MAN1 mutants accumulate more heterogeneously sized vesicles and multivesicular bodies in larval and adult synapses, the latter indicating that MAN1 may function in synaptic vesicle recycling and endosome-to-lysosome trafficking...
November 15, 2016: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/27847195/augmented-cognitive-behavioral-therapy-for-post-stroke-depressive-symptoms-a-randomized-controlled-trial
#6
Joyce A Kootker, Sascha Mc Rasquin, Frederik C Lem, Caroline M van Heugten, Luciano Fasotti, Alexander C Geurts
OBJECTIVE: To evaluate the effectiveness of individually tailored cognitive behavioral therapy (CBT) for reducing depressive symptoms with or without anxiety post stroke. DESIGN: Multi-center, assessor-blinded, randomized controlled trial. SETTING: Six ambulatory rehabilitation settings in The Netherlands. PARTICIPANTS: Patients who had a Hospital Anxiety and Depression Scale - subscale Depression (HADS-D) score > 7 at least three months post stroke...
November 12, 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27845354/concurrent-validity-of-single-and-groups-of-walking-assessments-following-acute-spinal-cord-injury
#7
A Aigner, A Curt, L G Tanadini, M H Maathuis
STUDY DESIGN: Retrospective analysis of prospectively collected longitudinal data. Variables of interest are timed and untimed walking assessments (10MWT, 6MWT, TUG, WISCI, SCIM3a, SCIM3b) and lower extremities motor scores (LEMS) from both sides' lower limb motor segments, measured five times within the first year after acute spinal cord injury (SCI). OBJECTIVES: Assessing concurrent validity of single and groups of walking assessments in comparison with LEMS in SCI patients...
November 15, 2016: Spinal Cord
https://www.readbyqxmd.com/read/27843577/age-affects-joint-space-narrowing-in-patients-with-early-active-rheumatoid-arthritis
#8
X M E Matthijssen, G Akdemir, I M Markusse, T Stijnen, N Riyazi, K H Han, C Bijkerk, P J S M Kerstens, W F Lems, T W J Huizinga, C F Allaart
BACKGROUND: Joint space narrowing (JSN) in rheumatoid arthritis (RA) may be a manifestation of (primary) osteoarthritis becoming more prominent with age. We investigated the severity and predictors of JSN progression among different age groups. METHODS: 10-year follow-up data of the BeSt study, a randomised controlled treat-to-target trial in early RA were used. Annual X-rays of hands and feet were scored using the Sharp/van der Heijde score (SHS). Subgroups were defined by age at baseline: ≥55, ≥40<55 and <40 years...
2016: RMD Open
https://www.readbyqxmd.com/read/27803349/dr-koeckhoven-et-al-reply
#9
Esmee Koeckhoven, Marike VAN DER Leeden, Leo D Roorda, Natasja M VAN Schoor, Paul Lips, Arjan DE Zwart, Joost Dekker, Martin VAN DER Esch, Willem F Lems
No abstract text is available yet for this article.
November 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27797637/beyond-tethering-and-the-lem-domain-mscellaneous-functions-of-the-inner-nuclear-membrane-lem2
#10
Sigurd Braun, Ramón Ramos Barrales
The nuclear envelope plays a pivotal role in the functional organization of chromatin. Various inner nuclear membrane (INM) proteins associate with transcriptionally repressed chromatin, which is often found at the nuclear periphery. A prominent example is the conserved family of LEM (LAP2-Emerin-MAN1) domain proteins that interact with DNA-binding proteins and have been proposed to mediate tethering of chromatin to the nuclear membrane. We recently reported that the fission yeast protein Lem2, a homolog of metazoan LEM proteins, contributes to perinuclear localization and silencing of heterochromatin...
October 31, 2016: Nucleus
https://www.readbyqxmd.com/read/27796445/biologic-therapies-and-bone-loss-in-rheumatoid-arthritis
#11
REVIEW
C A F Zerbini, P Clark, L Mendez-Sanchez, R M R Pereira, O D Messina, C R Uña, J D Adachi, W F Lems, C Cooper, N E Lane
INTRODUCTION: Rheumatoid arthritis (RA) is a common systemic autoimmune disease of unknown cause, characterized by a chronic, symmetric, and progressive inflammatory polyarthritis. One of the most deleterious effects induced by the chronic inflammation of RA is bone loss. During the last 15 years, the better knowledge of the cytokine network involved in RA allowed the development of potent inhibitors of the inflammatory process classified as biological DMARDs. These new drugs are very effective in the inhibition of inflammation, but there are only few studies regarding their role in bone protection...
October 31, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27787623/dietary-intake-and-biomarker-status-of-folate-in-swedish-adults
#12
Veronica Öhrvik, Eva Warensjö Lemming, Cecilia Nälsén, Wulf Becker, Peter Ridefelt, Anna Karin Lindroos
PURPOSE: National data on folate status are missing in Sweden, and regional data indicate folate insufficiency in up to more than 25% of the study populations. The objectives were to determine folate intake and status in the adult Swedish population as well as identifying dietary patterns associated with beneficial folate status. METHODS: Folate intake was estimated using a web-based 4-d food record in adults aged 18-80 years (n = 1797). Folate status was measured as erythrocyte (n = 282) and plasma folate concentrations (n = 294)...
October 27, 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/27783497/the-classification-of-gunshot-residue-using-laser-electrospray-mass-spectrometry-and-offline-multivariate-statistical-analysis
#13
Johnny J Perez, David A Watson, Robert J Levis
Nonresonant laser vaporization combined with high resolution time-of-flight mass spectrometry enables analysis of a casing after discharge of a firearm revealing organic signature molecules including methyl centralite (MC), diphenylamine (DPA), N-nitrosodiphenylamine (N-NO-DPA), 4-nitrodiphenylamine (4-NDPA), a DPA adduct and multiple unidentified features not observed in previous mass spectral measurements. Collision-induced dissociation measurements of unknown GSR signature ions reveals inorganic barium and derivatives BaOH, BaOHCH3, BaCH3COO remaining from the primer...
October 26, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27763834/profiling-a-one-health-model-for-priority-populations
#14
Casey Panning, Michelle Lem, Shane Bateman
No abstract available.
October 20, 2016: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/27752306/comparison-of-a-web-based-food-record-tool-and-a-food-frequency-questionnaire-and-objective-validation-using-the-doubly-labelled-water-technique-in-a-swedish-middle-aged-population
#15
Sanna Nybacka, Heléne Bertéus Forslund, Elisabet Wirfält, Ingrid Larsson, Ulrika Ericson, Eva Warensjö Lemming, Göran Bergström, Bo Hedblad, Anna Winkvist, Anna Karin Lindroos
Two web-based dietary assessment tools have been developed for use in large-scale studies: the Riksmaten method (4-d food record) and MiniMeal-Q (food-frequency method). The aim of the present study was to examine the ability of these methods to capture energy intake against objectively measured total energy expenditure (TEE) with the doubly labelled water technique (TEEDLW), and to compare reported energy and macronutrient intake. This study was conducted within the pilot study of the Swedish CArdioPulmonary bioImage Study (SCAPIS), which included 1111 randomly selected men and women aged 50-64 years from the Gothenburg general population...
2016: Journal of Nutritional Science
https://www.readbyqxmd.com/read/27737631/abstracts-reporting-of-hiv-aids-randomized-controlled-trials-in-general-medicine-and-infectious-diseases-journals-completeness-to-date-and-improvement-in-the-quality-since-consort-extension-for-abstracts
#16
Jean Joel R Bigna, Jean Jacques N Noubiap, Serra Lem Asangbeh, Lewis N Um, Paule Sandra D Sime, Elvis Temfack, Mathurin Cyrille Tejiokem
BACKGROUND: Sufficiently detailed abstracts of randomized controlled trials (RCTs) are important, because readers often base their assessment of a trial solely on information in the abstract. We aimed at comparing reporting quality of RCTs in HIV/AIDS medicine before and after the publication of the 2008 CONSORT extension for abstracts and to investigate factors associated with better reporting quality. METHODS: We searched PubMed/Medline for HIV/AIDS RCTs published between 2006-07 (Pre-CONSORT) and 2014-15 (Post-CONSORT) in 40 leading general medicine and infectious diseases journals...
October 13, 2016: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/27733427/chm7-and-heh1-collaborate-to-link-nuclear-pore-complex-quality-control-with-nuclear-envelope-sealing
#17
Brant M Webster, David J Thaller, Jens Jäger, Sarah E Ochmann, Sapan Borah, C Patrick Lusk
The integrity of the nuclear envelope barrier relies on membrane remodeling by the ESCRTs, which seal nuclear envelope holes and contribute to the quality control of nuclear pore complexes (NPCs); whether these processes are mechanistically related remains poorly defined. Here, we show that the ESCRT-II/III chimera, Chm7, is recruited to a nuclear envelope subdomain that expands upon inhibition of NPC assembly and is required for the formation of the storage of improperly assembled NPCs (SINC) compartment. Recruitment to sites of NPC assembly is mediated by its ESCRT-II domain and the LAP2-emerin-MAN1 (LEM) family of integral inner nuclear membrane proteins, Heh1 and Heh2...
November 15, 2016: EMBO Journal
https://www.readbyqxmd.com/read/27697512/dhcr7-a-vital-enzyme-switch-between-cholesterol-and-vitamin-d-production
#18
REVIEW
Anika V Prabhu, Winnie Luu, Dianfan Li, Laura J Sharpe, Andrew J Brown
The conversion of 7-dehydrocholesterol to cholesterol, the final step of cholesterol synthesis in the Kandutsch-Russell pathway, is catalyzed by the enzyme 7-dehydrocholesterol reductase (DHCR7). Homozygous or compound heterozygous mutations in DHCR7 lead to the developmental disease Smith-Lemli-Opitz syndrome, which can also result in fetal mortality, highlighting the importance of this enzyme in human development and survival. Besides serving as a substrate for DHCR7, 7-dehydrocholesterol is also a precursor of vitamin D via the action of ultraviolet light on the skin...
September 30, 2016: Progress in Lipid Research
https://www.readbyqxmd.com/read/27696732/short-and-sustained-periods-of-acr-eular-remission-predict-good-functional-outcome-but-do-not-predict-good-radiographic-outcome-in-early-rheumatoid-arthritis-patients-with-low-overall-damage-progression
#19
Nicole P C Konijn, Lilian H D van Tuyl, Maarten Boers, Debby den Uyl, Marieke M Ter Wee, Pit Kerstens, Alexandre E Voskuyl, Dirkjan van Schaardenburg, Michael T Nurmohamed, Willem F Lems
OBJECTIVE: To investigate whether remission at single and consecutive visits predicts good outcome in early rheumatoid arthritis (RA). METHODS: The presence of remission according to ACR/EULAR and other criteria (Boolean clinical, CDAI, DAS, DAS28, RAPID3) was assessed in early RA patients during the first year of the COBRA-light trial. Likelihood ratios were used to assess whether meeting the remission criteria at single visits (13, 26, 39 or 52 weeks) and consecutive visits (13 + 26, 26 + 39 or 39 + 52 weeks) predicted good outcome in the second year (52-104 weeks)...
October 1, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27680540/rheumatologists-adherence-to-a-disease-activity-score-steered-treatment-protocol-in-early-arthritis-patients-is-less-if-the-target-is-remission
#20
G Akdemir, I M Markusse, Y P M Goekoop-Ruiterman, G M Steup-Beekman, B A M Grillet, P J S M Kerstens, W F Lems, T W J Huizinga, C F Allaart
To compare rheumatologists' adherence to treatment protocols for rheumatoid arthritis (RA) targeted at Disease Activity Score (DAS) ≤2.4 or <1.6. The BeSt-study enrolled 508 early RA (1987) patients targeted at DAS ≤2.4. The IMPROVED-study included 479 early RA (2010) and 122 undifferentiated arthritis patients targeted at DAS <1.6. We evaluated rheumatologists' adherence to the protocols and assessed associated opinions and conditions during 5 years. Protocol adherence was higher in BeSt than in IMPROVED (86 and 70 %), with a greater decrease in IMPROVED (from 100 to 48 %) than in BeSt (100 to 72 %)...
September 28, 2016: Clinical Rheumatology
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