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https://www.readbyqxmd.com/read/28238874/ebv-early-lytic-protein-bfrf1-alters-emerin-distribution-and-post-translational-modification
#1
S Yadav, F Libotte, E Buono, S Valia, G A Farina, A Faggioni, A Farina
The nuclear envelope (NE), a structural element of fundamental importance for the cell, is the first barrier that meets a virus in the early stages of viral maturation. Therefore, in order to allow the passage of nucleocapsids, viruses are known to modulate the architecture of the nuclear membrane to permit a proficient viral infection. Epstein-Barr Virus (EBV), a pathogen from Herpesvirus family, possesses two well conserved proteins, BFRF1 and BFLF2, which together form the heterodimeric nuclear egress complex (NEC) that is involved in the early steps of nuclear egress...
February 23, 2017: Virus Research
https://www.readbyqxmd.com/read/28236655/targeted-dose-enhancement-in-radiotherapy-for-breast-cancer-using-gold-nanoparticles-part-1-a-radiobiological-model-study
#2
Veronica Ferrero, Giovanni Visonà, Federico Dalmasso, Andrea Gobbato, Piergiorgio Cerello, Andrea Attili, Lidia Strigari, Sonja Visentin
PURPOSE: Gold nanoparticles (GNPs) are being proposed in combination with radiotherapy to improve tumor control. However, the exact mechanisms underlying GNP radiosensitization are yet to be understood, thus, we present a new approach to estimate the nanoparticle-driven increase in radiosensitivity. METHODS: A stochastic radiobiological model derived from the Local Effect Model (LEM) was coupled with Monte Carlo simulations performed using to estimate the increase in radiosensitivity due to the local dose deposited by secondary electrons produced from the interaction between the photons and GNPs at a nanometric level...
February 25, 2017: Medical Physics
https://www.readbyqxmd.com/read/28235621/effects-of-twelve-weeks-of-capsaicinoid-supplementation-on-body-composition-appetite-and-self-reported-caloric-intake-in-overweight-individuals
#3
Stacie L Urbina, Michael D Roberts, Wesley C Kephart, Katelyn B Villa, Emily N Santos, Alyssa M Olivencia, Haley M Bennett, Marissa D Lara, Cliffa A Foster, Martin Purpura, Ralf Jäger, Lem W Taylor, Colin D Wilborn
We examined if 12 weeks of capsaicinoid (CAP) supplementation affected appetite, body composition and metabolic health markers. Seventy seven healthy male and female volunteers (30 ± 1 y, 171.2 ± 9.8 cm, 81.0 ± 2.2 kg, 27.5 ± 0.6 kg/m(2)) were randomly assigned to ingest either low-dose CAP (2 mg/d; L-CAP, n = 27), high-dose CAP (4 mg/d; H-CAP, n = 22) from Capsimax or placebo (corn starch; PLA, n = 28) for 12 weeks. At baseline (0 WK), 6 weeks (6 WK) and 12 weeks (12 WK) waist: hip ratio, body composition via dual energy x-ray absorptiometry (DEXA, 0 WK and 12 WK only), self-reported Calorie intakes, appetite levels via Council on Nutrition Appetite Questionnaire (CNAQ) and serum metabolic health markers (0 WK and 12 WK only) were analyzed...
February 21, 2017: Appetite
https://www.readbyqxmd.com/read/28229441/-robotic-systems-for-gait-re-education-in-cases-of-spinal-cord-injury-a-systematic-review
#4
T Gandara-Sambade, M Fernandez-Pereira, A Rodriguez-Sotillo
INTRODUCTION: The evidence underlying robotic body weight supported treadmill training in patients with spinal cord injury remains poorly characterized. AIM: To perform a qualitative systematic review on the efficacy of this therapy. PATIENTS AND METHODS: A search on PubMed, CINAHL, Cochrane Library and PEDro was performed from January 2005 to April 2016. The references in these articles were also reviewed to find papers not identified with the initial search strategy...
March 1, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28220990/oxidative-stress-serotonergic-changes-and-decreased-ultrasonic-vocalizations-in-a-mouse-model-of-smith-lemli-opitz-syndrome
#5
Navila F Sharif, Zeljka Korade, Ned A Porter, Harrison Fiona E
Smith Lemli Opitz syndrome is an inherited monogenic disorder in which mutations to the Dhcr7 gene lead to deficits in cholesterol synthesis. As a result, many patients suffer from gross physiological and neurological deficits. The purpose of this study was to identify a potential abnormal behavioral phenotype in a compound mutant mouse model for Smith Lemli Opitz disease (Dhcr7(Δ3)(-5/)(T93M) ) to further validate the model, and to provide potential targets for future therapeutic interventions. We also sought to identify some of the underlying changes in brain function that may be responsible for behavioral differences among groups...
February 21, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28219643/identification-and-functional-analysis-of-variants-of-a-cancer-testis-antigen-lemd1-in-colorectal-cancer-stem-like-cells
#6
Rui Takeda, Yoshihiko Hirohashi, Min Shen, Liming Wang, Tadashi Ogawa, Aiko Murai, Eri Yamamoto, Terufumi Kubo, Munehide Nakatsugawa, Takayuki Kanaseki, Tomohide Tsukahara, Toshihiko Nishidate, Kenji Okita, Goro Kutomi, Noriyuki Sato, Ichiro Takemasa, Toshihiko Torigoe
Colorectal cancer (CRC) is one of the most common malignancy, and the prognosis is not still satisfactory due to treatment resistance, recurrence and distant metastasis. Cancer stem cells (CSCs)/cancer-initiating cells (CICs) is endowed with higher tumor-initiating ability, self-renewal ability and differentiation ability, and CSCs/CICs are resistant to treatments. Thus, CSCs/CICs are thought to be responsible for recurrence and distant metastasis, and eradication of CSCs/CICs is essential to cure CRCs. However, the molecular mechanisms of CSCs/CICs are remain unknown, and we aimed to elucidate molecular aspects of CR-CSCs/CICs in this study...
February 17, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28217175/a-local-effect-model-based-interpolation-framework-for-experimental-nanoparticle-radiosensitisation-data
#7
Jeremy M C Brown, Fred J Currell
A local effect model (LEM)-based framework capable of interpolating nanoparticle-enhanced photon-irradiated clonogenic cell survival fraction measurements as a function of nanoparticle concentration was developed and experimentally benchmarked for gold nanoparticle (AuNP)-doped bovine aortic endothelial cells (BAECs) under superficial kilovoltage X-ray irradiation. For three different superficial kilovoltage X-ray spectra, the BAEC survival fraction response was predicted for two different AuNP concentrations and compared to experimental data...
2017: Cancer Nanotechnology
https://www.readbyqxmd.com/read/28209728/evaluation-of-cell-therapy-on-exercise-performance-and-limb-perfusion-in-peripheral-artery-disease-the-cctrn-patients-with-intermittent-claudication-injected-with-aldh-bright-cells-pace-trial
#8
Emerson C Perin, Michael P Murphy, Keith L March, Roberto Bolli, John Loughran, Phillip C Yang, Nicholas J Leeper, Ronald L Dalman, Jason Q Alexander, Timothy D Henry, Jay H Traverse, Carl J Pepine, R David Anderson, Scott Berceli, James T Willerson, Raja Muthupillai, Amir A Gahremanpour, Ganesh Raveendran, Omaida C Velazquez, Joshua M Hare, Ivonne H Schulman, Vijaykumar S Kasi, William R Hiatt, Bharath Ambale-Venkatesh, João A Lima, Doris A Taylor, Micheline M Resende, Adrian P Gee, April G Durett, Jeannette Bloom, Sara Richman, Patricia G'Sell, Shari Williams, Fouzia Khan, Elsie G Ross, Michelle R Santoso, JoAnne Goldman, Dana Leach, Eileen Handberg, Benjamin Y C Cheong, Nichole A Piece, Darcy DiFede, Barb Bruhn-Ding, Emily Caldwell, Judy Bettencourt, Dejian Lai, Linda B Piller, Lara M Simpson, Michelle Cohen, Shelly L Sayre, Rachel W Vojvodic, Lem Moyé, Ray F Ebert, Robert D Simari, Alan T Hirsch
Background -Atherosclerotic peripheral artery disease (PAD) affects 8-12% of Americans over 65 and is associated with a major decline in functional status, increased myocardial infarction and stroke rates, and increased risk of ischemic amputation. Current treatment strategies for claudication have limitations. PACE is an NHLBI-sponsored, randomized, double-blind, placebo-controlled phase 2, exploratory clinical trial designed to assess safety and efficacy of autologous bone marrow-derived aldehyde dehydrogenase bright (ALDHbr) cells in PAD patients and to explore associated claudication physiologic mechanisms...
February 16, 2017: Circulation
https://www.readbyqxmd.com/read/28199724/cardiovascular-risk-management-in-rheumatoid-arthritis-patients-still-suboptimal-the-implementation-of-cardiovascular-risk-management-in-rheumatoid-arthritis-project
#9
Inge A M van den Oever, Maaike Heslinga, Ed N Griep, Hanneke R M Griep-Wentink, Rob Schotsman, Walter Cambach, Ben A C Dijkmans, Yvo M Smulders, Willem F Lems, Maarten Boers, Alexandre E Voskuyl, Mike J L Peters, Dirkjan van Schaardenburg, Micheal T Nurmohamed
No abstract text is available yet for this article.
February 10, 2017: Rheumatology
https://www.readbyqxmd.com/read/28174017/propagation-rate-constants-for-the-peroxidation-of-sterols-on-the-biosynthetic-pathway-to-cholesterol
#10
Connor R Lamberson, Hubert Muchalski, Kari B McDuffee, Keri A Tallman, Libin Xu, Ned A Porter
The free radical chain autoxidation of cholesterol and the oxidation products formed, i.e. oxysterols, have been the focus of intensive study for decades. The peroxidation of sterol precursors to cholesterol such as 7-dehydrocholesterol (7-DHC) and desmosterol as well as their oxysterols has received less attention. The peroxidation of these sterol precursors can become important under circumstances in which genetic conditions or exposures to small molecules leads to an increase of these biosynthetic intermediates in tissues and fluids...
February 5, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/28166604/smith-lemli-opitz-syndrome-carrier-frequency-and-estimates-of-in-utero-mortality-rates
#11
Gabriel A Lazarin, Imran S Haque, Eric A Evans, James D Goldberg
OBJECTIVE: To tabulate individual allele frequencies and total carrier frequency for Smith-Lemli-Opitz syndrome (SLOS) and compare expected versus observed birth incidences. METHODS: 262,399 individuals with no known indication or increased probability of SLOS carrier status, primarily US-based, were screened for SLOS mutations as part of an expanded carrier screening panel. Results were retrospectively analyzed to estimate carrier frequencies in multiple ethnic groups...
February 6, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28151079/exposure-to-lyssaviruses-in-bats-of-the-democratic-republic-of-the-congo
#12
Lem's N Kalemba, Michael Niezgoda, Amy T Gilbert, Jeffrey B Doty, Ryan M Wallace, Jean M Malekani, Darin S Carroll
Lyssavirus infections in the Democratic Republic of Congo are poorly documented. We examined 218 bats. No lyssavirus antigens were detected but Lagos bat virus (LBV) neutralizing antibodies (VNA) were detected in Eidolon helvum and Myonycteris torquata . Four samples with LBV VNA reacted against Shimoni bat virus.
February 2, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28135601/interaction-of-quercetin-and-its-metabolites-with-warfarin-displacement-of-warfarin-from-serum-albumin-and-inhibition-of-cyp2c9-enzyme
#13
Miklós Poór, Gabriella Boda, Paul W Needs, Paul A Kroon, Beáta Lemli, Tímea Bencsik
Flavonoids are ubiquitous molecules in nature with manifold pharmacological effects. Flavonoids interact with several proteins, and thus potentially interfere with the pharmacokinetics of various drugs. Though much is known about the protein binding characteristics of flavonoid aglycones, the behaviour of their metabolites, which are extensively formed in the human body has received little attention. In this study, the interactions of the flavonoid aglycone quercetin and its main metabolites with the albumin binding of the oral anticoagulant warfarin were investigated by fluorescence spectroscopy and ultrafiltration...
January 27, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28101369/a-single-gene-controls-leaf-background-color-in-caladium-araceae-and-is-tightly-linked-to-genes-for-leaf-main-vein-color-spotting-and-rugosity
#14
Zhe Cao, Shunzhao Sui, Qian Yang, Zhanao Deng
Modern cultivated caladiums (Caladium×hortulanum) are grown for their long-lasting and colorful leaves. Understanding the mode of inheritance for caladium leaf characteristics is critical for plant breeders to select appropriate parents, predict progeny performance, estimate breeding population sizes needed, and increase breeding efficiencies. This study was conducted to determine the mode of inheritance of two leaf background colors (lemon and green) in caladium and to understand their relationships with four other important leaf characteristics including leaf shape, main vein color, spotting, and rugosity...
2017: Horticulture Research
https://www.readbyqxmd.com/read/28087213/cholesterolomics-an-update
#15
William J Griffiths, Jonas Abdel-Khalik, Eylan Yutuc, Alwena H Morgan, Ian Gilmore, Thomas Hearn, Yuqin Wang
Cholesterolomics can be regarded as the identification and quantification of cholesterol, its precursors post squalene, and metabolites of cholesterol and of its precursors, in a biological sample. These molecules include 1,25-dihydroxyvitamin D3, steroid hormones and bile acids and intermediates in their respective biosynthetic pathways. In this short article we will concentrate our attention on intermediates in bile acid biosynthesis pathways, in particular oxysterols and cholestenoic acids. These molecular classes are implicated in the aetiology of a diverse array of diseases including autoimmune disease, Parkinson's disease, motor neuron disease, breast cancer, the lysosomal storage disease Niemann-Pick type C and the autosomal recessive disorder Smith-Lemli-Opitz syndrome...
January 10, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/28072575/systematics-of-relative-biological-effectiveness-measurements-for-proton-radiation-along-the-spread-out-bragg-peak-experimental-validation-of-the-local-effect-model
#16
Rebecca Grün, Thomas Friedrich, Michael Krämer, Michael Scholz
The purpose of this study is to compare the predictions of the local effect model (LEM) in an extensive analysis to proton relative biological effectiveness (RBE) experiments found in the literature, and demonstrate the capabilities of the model as well as to discuss potential limitations. 19 publications with in vitro experiments and 10 publications with in vivo experiments focusing on proton RBE along the spread out Bragg peak (SOBP) were considered. In total the RBE values of over 100 depth positions were compared to LEM predictions...
February 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28053139/cuff-pressure-pain-detection-is-associated-with-both-sex-and-physical-activity-level-in-nonathletic-healthy-subjects
#17
Dag Lemming, Björn Börsbo, Anna Sjörs, Eva-Britt Lind, Lars Arendt-Nielsen, Thomas Graven-Nielsen, Björn Gerdle
: PURPOSE : The aim of this study was to evaluate pressure pain sensitivity on leg and arm in 98 healthy persons (50 women) using cuff algometry. Furthermore, associations with sex and physical activity level were investigated. METHOD:  Normal physical activity level was defined as Godin Leisure-Time Exercise Questionnaire (GLTEQ) score ≤ 45 and high activity level as GLTEQ > 45. A pneumatic double-chamber cuff was placed around the arm or leg where a single chamber was inflated...
January 4, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28048335/su-g-tep3-13-the-role-of-nanoscale-energy-deposition-in-the-development-of-gold-nanoparticle-enhanced-radiotherapy
#18
C Kirkby, B Koger, N Suchowerska, D McKenzie
PURPOSE: Gold nanoparticles (GNPs) can enhance radiotherapy effects. The high photoelectric cross section of gold relative to tissue, particularly at lower energies, leads to localized dose enhancement. However in a clinical context, photon energies must also be sufficient to reach a target volume at a given depth. These properties must be balanced to optimize such a therapy. Given that nanoscale energy deposition patterns around GNPs play a role in determining biological outcomes, in this work we seek to establish their role in this optimization process...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047315/su-f-t-124-radiation-biological-equivalent-presentations-oflem-1-and-mkm-approaches-in-the-carbon-ion-radiotherapy
#19
W Hsi, G Jiang, Y Sheng
PURPOSE: To study the correlations of the radiation biological equivalent doses (BED) along depth and lateral distance between LEM-1 and MKM approaches. METHODS: In NIRS-MKM (Microdosimetric Kinetic Model) approach, the prescribed BED, referred as C-Eq, doses aims to present the relative biological effectiveness (RBE) for different energies of carbon-ions on a fixed 10% survival value of HCG cell with respect to convention X-ray. Instead of a fixed 10% survival, the BED doses of LEM-1 (Local Effect Model) approach, referred as X-Eq, aims to present the RBE over the whole survival curve of chordoma-like cell with alpha/beta ratio of 2...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047295/tu-h-206-04-an-effective-homomorphic-unsharp-mask-filtering-method-to-correct-intensity-inhomogeneity-in-daily-treatment-mr-images
#20
D Yang, H Gach, H Li, S Mutic
PURPOSE: The daily treatment MRIs acquired on MR-IGRT systems, like diagnostic MRIs, suffer from intensity inhomogeneity issue, associated with B1 and B0 inhomogeneities. An improved homomorphic unsharp mask (HUM) filtering method, automatic and robust body segmentation, and imaging field-of-view (FOV) detection methods were developed to compute the multiplicative slow-varying correction field and correct the intensity inhomogeneity. The goal is to improve and normalize the voxel intensity so that the images could be processed more accurately by quantitative methods (e...
June 2016: Medical Physics
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