keyword
MENU ▼
Read by QxMD icon Read
search

Lems

keyword
https://www.readbyqxmd.com/read/28505552/probabilistic-pharmacokinetic-models-of-decompression-sickness-in-humans-part-1-coupled-perfusion-limited-compartments
#1
F Gregory Murphy, Ethan A Hada, David J Doolette, Laurens E Howle
Decompression sickness (DCS) is a disease caused by gas bubbles forming in body tissues following a reduction in ambient pressure, such as occurs in scuba diving. Probabilistic models for quantifying the risk of DCS are typically composed of a collection of independent, perfusion-limited theoretical tissue compartments which describe gas content or bubble volume within these compartments. It has been previously shown that 'pharmacokinetic' gas content models, with compartments coupled in series, show promise as predictors of the incidence of DCS...
May 4, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28503313/novel-dhcr7-mutation-in-a-case-of-smith-lemli-opitz-syndrome-showing-46-xy-disorder-of-sex-development
#2
Mayuko Tamura, Tsuyoshi Isojima, Takeshi Kasama, Ryo Mafune, Konomi Shimoda, Hiroki Yasudo, Hiroyuki Tanaka, Chie Takahashi, Akira Oka, Sachiko Kitanaka
Smith-Lemli-Opitz syndrome is an autosomal recessive disease caused by mutations in 7-dehydrocholesterol reductase (DHCR7), which is rarely observed in Japan. We report a Japanese case with 46,XY disorder of sex development and Y-shaped 2-3 toe syndactyly. DHCR7 gene analysis revealed compound heterozygous mutations including the novel mutation H442R. Early diagnosis led to starting cholesterol treatment at an early age.
2017: Human Genome Variation
https://www.readbyqxmd.com/read/28491172/acquired-uterine-arteriovenous-fistula-following-dilatation-and-curettage-an-uncommon-cause-of-vaginal-bleeding
#3
Adam Evans, Roland E Gazaille, Richard McKenzie, Meghan Musser, Robert Lemming, Jarrod Curry, William Meyers, Nicholas Austin
Dysfunctional uterine bleeding is a common presentation of women in the emergency department. We describe the case of a 33-year-old female who presented with intermittent spotting due to an acquired uterine AVF. The patient underwent a transvaginal pelvic ultrasound as well as a CT angiogram. The patient was treated conservatively and elected to undergo uterine artery embolization in an effort to preserve fertility. She successfully delivered a healthy baby boy at 39-week gestation via an emergent caesarian section due to a prolapsed umbilical cord 17 months after undergoing the uterine artery embolization...
June 2017: Radiology case reports
https://www.readbyqxmd.com/read/28461515/is-fragility-fracture-a-strong-risk-factor-for-a-cardiovascular-event-in-rheumatoid-arthritis-the-challenge-of-dealing-with-multiple-comorbidities
#4
EDITORIAL
https://www.readbyqxmd.com/read/28447339/activity-of-anti-inflammatory-analgesic-and-antigenotoxic-of-the-aqueous-flower-extracts-of-opuntia-microdasys-lem-pfeiff
#5
Hassiba Chahdoura, Safia El Bok, Taoufik Refifa, Khaoula Adouni, Fethia Khemiss, Habib Mosbah, Mossadok Ben-Attia, Guido Flamini, Lotfi Achour
OBJECTIVES: The aim of this study was to evaluate the analgesic and the anti-inflammatory activity of Opuntia microdasys at post flowering stage, F3 (OMF3) in rat and, in other hand, its antigenotoxic effects by the Allium cepa test. METHODS: OMF3 extracts were screened for activity of analgesic and anti-inflammatory using, respectively, the acetic acid writhing test in mice and the carrageenan-induced paw oedema assay in rats. The antigenotoxic has been evaluated by A...
April 26, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28422505/probing-homogeneous-line-broadening-in-cdse-nanocrystals-using-multidimensional-electronic-spectroscopy
#6
Tobias A Gellen, Jet Lem, Daniel B Turner
The finite spectral line width of an ensemble of CdSe nanocrystals arises from size and shape inhomogeneity and the single-nanocrystal spectrum itself. This line width directly limits the performance of nanocrystal-based devices, yet most optical measurements cannot resolve the underlying contributions. We use two-dimensional electronic spectroscopy (2D ES) to measure the line width of the band-edge exciton of CdSe nanocrystals as a function of radii and surface chemistry. We find that the homogeneous width decreases for increasing nanocrystal radius and that surface chemistry plays a critical role in controlling this line width...
April 20, 2017: Nano Letters
https://www.readbyqxmd.com/read/28407177/mrna-and-protein-expression-levels-of-four-candidate-genes-for-ear-size-in-erhualian-and-large-white-pigs
#7
L C Zhang, J Liang, L Pu, Y B Zhang, L G Wang, X Liu, H Yan, L X Wang
Porcine ear size is an important characteristic for distinguishing among pig breeds. In a previous genome-wide association study of porcine ear size, LEM domain-containing 3 (LEMD3), methionine sulfoxide reductase B3 (MSRB3), high mobility group AT-hook 2 (HMGA2), and Wnt inhibitory factor 1 (WIF1) were implicated as important candidate genes for ear size. This study investigated the expression levels of four candidate genes for ear size in Erhualian and Large White pigs. Ten Erhualian pigs with large ears and eight Large White pigs with small ears at 60 days of age were examined...
April 13, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28398483/function-of-nuclear-membrane-proteins-in-shaping-the-nuclear-envelope-integrity-during-closed-mitosis
#8
Hui-Ju Yang, Masaaki Iwamoto, Yasushi Hiraoka, Tokuko Haraguchi
The nuclear envelope (NE) not only protects the genome from being directly accessed by detrimental agents but also regulates genome organization. Breaches in NE integrity threaten genome stability and impede cellular function. Nonetheless, the NE constantly remodels, and NE integrity is endangered in dividing or differentiating cells. Specifically, in unicellular eukaryotes undergoing closed mitosis, the NE expands instead of breaking down during chromosome segregation. The newly assembling nuclear pore complexes (NPCs) penetrate the existing NE in interphase...
June 1, 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/28392140/estimated-protective-effectiveness-of-intramuscular-immune-serum-globulin-post-exposure-prophylaxis-during-a-measles-outbreak-in-british-columbia-canada-2014
#9
Mark Bigham, Michelle Murti, Christina Fung, Felicity Hemming, Susan Loadman, Robert Stam, Paul Van Buynder, Marcus Lem
INTRODUCTION: Intramuscular Immune Serum Globulin (IM ISG) is recommended as post-measles exposure prophylaxis (PEP) when administered within 6days of initial exposure, with variable effectiveness in preventing measles disease. Effectiveness of IM ISG PEP in preventing clinical measles was assessed during a 2014 measles outbreak among a religious-affiliated community in British Columbia, Canada. MATERIAL AND METHODS: Fifty-five self-reporting measles susceptible contacts were offered exclusively IM ISG PEP within an eligibility period best surmised to be within 6days of initial measles case exposure...
May 9, 2017: Vaccine
https://www.readbyqxmd.com/read/28384423/assessing-stress-in-arctic-lemmings-fecal-metabolite-levels-reflect-plasma-free-corticosterone-levels
#10
Dominique Fauteux, Gilles Gauthier, Dominique Berteaux, Curtis Bosson, Rupert Palme, Rudy Boonstra
Interest in the ecology of stress in wild populations has triggered the development of noninvasive methods for quantifying stress hormones. Measurement of fecal corticosteroid metabolites (FCMs) is one such method, but it is still unclear whether FCMs can be a reliable proxy of free plasma glucocorticoids. To assess the validity of this assumption, we carried out a robust assessment on brown lemmings (Lemmus trimucronatus) from Bylot Island, Nunavut, Canada, that were hand captured and anesthetized and related plasma glucocorticoid levels to fecal metabolite glucocorticoid levels...
May 2017: Physiological and Biochemical Zoology: PBZ
https://www.readbyqxmd.com/read/28374700/-decrement-pattern-of-m-response-amplitude-in-the-low-frequency-repetitive-nerve-stimulation-in-the-muscles-of-patients-with-myasthenia-gravis-and-lambert-eaton-myasthenic-syndrome
#11
D A Tumurov, A G Sanadze
AIM: To investigate the pattern of decrement in the muscles of patients with myasthenia gravis (MG) and Lambert-Eaton myasthenic syndrome (LEMS). MATERIAL AND METHODS: Twenty-seven patients with MG and 39 patients with LEMS were studied using low frequency repetitive nerve stimulation (3/ sec). RESULTS AND CONCLUSION: The decrease of safety factor of neuromuscular transmission was equal in both groups. At the same time, a significant difference in the decrease of pattern of the amplitude compound of muscle action potential (CMAP) was found...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28365582/the-relationship-between-cardiac-conduction-times-cardiovascular-risk-factors-and-inflammation-in-patients-with-early-arthritis
#12
Samina A Turk, Sjoerd C Heslinga, Jill Dekker, Linda Britsemmer, Véronique van der Lugt, Willem F Lems, Dirkjan van Schaardenburg, Michael T Nurmohamed
OBJECTIVE: To investigate the prevalence of conduction disorders in patients with early arthritis and the relationship with inflammation and traditional cardiovascular (CV) risk factors. METHODS: Patients with rheumatoid arthritis (RA) have a 2-fold higher risk of sudden cardiac death, possibly owing to conduction disorders. This increased risk might already be present at the clinical onset of arthritis. Therefore, we assessed electrocardiography, blood pressure, 28-joint Disease Activity Score (DAS28), lipid profile, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) level in 480 patients with early arthritis at baseline and after 1 year...
May 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28365492/interaction-of-mycotoxin-zearalenone-with-human-serum-albumin
#13
Miklós Poór, Sándor Kunsági-Máté, Mónika Bálint, Csaba Hetényi, Zsófia Gerner, Beáta Lemli
Zearalenone (ZEN) is a mycotoxin produced mainly by Fusarium species. Fungal contamination of cereals and plants can result in the formation of ZEN, leading to its presence in different foods, animal feeds, and drinks. Because ZEN is an endocrine disruptor, it causes reproductive disorders in farm animals and hyperoestrogenic syndromes in humans. Despite toxicokinetic properties of ZEN were studied in more species, we have no information regarding the interaction of ZEN with serum albumin. Since albumin commonly plays an important role in the toxicokinetics of different toxins, interaction of ZEN with albumin has of high biological importance...
March 27, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28357352/chromatin-binding-and-silencing-two-roles-of-the-same-protein-lem2
#14
COMMENT
Ramón Ramos Barrales, Sigurd Braun
Transcriptionally repressed chromatin localizes to specific areas within the eukaryotic nucleus and is often found at the nuclear periphery, which is thought to provide a specialized compartment for gene silencing. However, the molecular mechanisms that establish this spatial chromatin organization are still poorly understood. In our recent work (Barrales et al. 2016), we identified the nuclear envelope protein Lem2, a homolog of metazoan lamin-associated proteins (LAPs), as a relevant factor for heterochromatin silencing and perinuclear localization in the fission yeast Schizosaccharomyces pombe...
April 4, 2016: Microbial Cell
https://www.readbyqxmd.com/read/28356123/epidemiology-of-chronic-obstructive-pulmonary-disease-in-the-global-hiv-infected-population-a-systematic-review-and-meta-analysis-protocol
#15
Jean Joel R Bigna, Angeladine Malaha Kenne, Serra Lem Asangbeh
BACKGROUND: Evidence suggests a relationship between human immunodeficiency virus (HIV) infection and chronic obstructive pulmonary disease (COPD). Although the high burden of COPD and the HIV disease is clearly demonstrated, to the best of our knowledge, there is a lack of summary and meta-analysis data on the epidemiology of COPD in the global HIV-infected population to date. The present protocol for a systematic review and meta-analysis intends to summarize existing data on the prevalence, incidence, and risk factors of COPD in the global HIV-infected population...
March 29, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28349652/normal-iq-is-possible-in-smith-lemli-opitz-syndrome
#16
Yasemen Eroglu, Mina Nguyen-Driver, Robert D Steiner, Louise Merkens, Mark Merkens, Jean-Baptiste Roullet, Ellen Elias, Geeta Sarphare, Forbes D Porter, Chumei Li, Elaine Tierney, Małgorzata Nowaczyk, Kurt A Freeman
Children with Smith-Lemli-Opitz syndrome (SLOS) are typically reported to have moderate to severe intellectual disability. This study aims to determine whether normal cognitive function is possible in this population and to describe clinical, biochemical and molecular characteristics of children with SLOS and normal intelligent quotient (IQ). The study included children with SLOS who underwent cognitive testing in four centers. All children with at least one IQ composite score above 80 were included in the study...
March 27, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28333546/pharmacokinetics-and-safety-of-vortioxetine-in-pediatric-patients
#17
Robert L Findling, Adelaide S Robb, Melissa DelBello, Michael Huss, Nora McNamara, Elias Sarkis, Russell Scheffer, Lis H Poulsen, Grace Chen, Ole Michael Lemming, Johan Areberg, Philippe Auby
OBJECTIVE: The primary objectives of this study were to evaluate the pharmacokinetics (PK) and tolerability of single and multiple doses of vortioxetine in children and adolescents with a depressive or anxiety disorder and to provide supportive information for appropriate dosing regimens for pediatric clinical trials. METHODS: This prospective, open-label, multinational, multisite, multiple-dose trial enrolled 48 patients (children and adolescents; 1:1 ratio) divided into 8 cohorts (4 adolescent and 4 child), with each cohort including 6 patients...
March 23, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28330471/robot-assisted-gait-training-lokomat-improves-walking-function-and-activity-in-people-with-spinal-cord-injury-a-systematic-review
#18
REVIEW
Ki Yeun Nam, Hyun Jung Kim, Bum Sun Kwon, Jin-Woo Park, Ho Jun Lee, Aeri Yoo
Robot-assisted gait training (RAGT) after spinal cord injury (SCI) induces several different neurophysiological mechanisms to restore walking ability, including the activation of central pattern generators, task-specific stepping practice and massed exercise. However, there is no clear evidence for the optimal timing and efficacy of RAGT in people with SCI. The aim of our study was to assess the effects of RAGT on improvement in walking-related functional outcomes in patients with incomplete SCI compared with other rehabilitation modalities according to time elapsed since injury...
March 23, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28327154/the-effect-of-social-behavior-change-communication-package-on-maternal-knowledge-in-obstetric-danger-signs-among-mothers-in-east-mamprusi-district-of-ghana
#19
Mahama Saaka, Paul Aryee, Robert Kuganab-Lem, Mohammed Ali, Abdul Razak Masahudu
BACKGROUND: An understanding of maternal knowledge of the danger signs of obstetric and newborn complications is fundamental to attaining universal health coverage. In Northern Ghana, where maternal and newborn morbidity and mortality is high, little is known about the current knowledge level and associated determinants of these danger signs. This study assessed the effect of social behavior change communication (SBCC) package on knowledge of obstetric and newborn danger signs among mothers with children under 24 months of age...
March 21, 2017: Globalization and Health
https://www.readbyqxmd.com/read/28322876/predator-prey-subsidy-population-dynamics-on-stepping-stone-domains
#20
Lulan Shen, Robert A Van Gorder
Predator-prey-subsidy dynamics on stepping-stone domains are examined using a variety of network configurations. Our problem is motivated by the interactions between arctic foxes (predator) and lemmings (prey) in the presence of seal carrion (subsidy) provided by polar bears. We use the n-Patch Model, which considers space explicitly as a "Stepping Stone" system. We consider the role that the carrying capacity, predator migration rate, input subsidy rate, predator mortality rate, and proportion of predators surviving migration play in the predator-prey-subsidy population dynamics...
March 18, 2017: Journal of Theoretical Biology
keyword
keyword
21025
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"