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https://www.readbyqxmd.com/read/29471469/effect-of-lemon-leaves-on-energy-and-c-n-balances-methane-emission-and-milk-performance-in-murciano-granadina-dairy-goats
#1
C Fernández, J V Marti, I Pérez-Baena, J L Palomares, C Ibáñez, J V Segarra
The objective of this experiment was to find out the effect of lemon leaves on energy and C-N balances, methane emission, and milk performance in dairy goats. Lemon leaves were used to replace alfalfa as forage in a diet for Murciano-Granadina goats. Ten Murciano-Granadina dairy goats (44.1 ± 4.47 kg of BW) in late lactation (185 ± 7.2 d) were selected in a crossover design experiment, where each goat received two treatments in 2 periods. One group was fed a mixed ration with 450 g of pelleted alfalfa/kg of DM (ALF diet) and, the other group replaced alfalfa with 450 g of pelleted lemon leaves/kg DM (LEM diet)...
February 17, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29471377/tnf-inhibitor-treatment-is-associated-with-a-lower-risk-of-hand-osteoarthritis-progression-in-rheumatoid-arthritis-patients-after-10-years
#2
Marieke Loef, Féline P B Kroon, Sytske Anne Bergstra, Joy A van der Pol, Willem F Lems, Pit J S M Kerstens, Cornelia F Allaart, Margreet Kloppenburg
Objective: To investigate the effect of TNF inhibitors (TNFis) on incidental and progressive hand OA in recent-onset RA patients after a 10 year follow-up. Methods: Radiographs of 262 RA patients (mean age 52 years, 66% women) from the BeSt study were scored for osteophytes in DIP/PIP joints using the Osteoarthritis Research Society International atlas (0-3; summed score 0-54) and according to the Kellgren-Lawrence (KL) score (0-4; summed score 0-72) at baseline and 10 year follow-up...
February 19, 2018: Rheumatology
https://www.readbyqxmd.com/read/29464895/selective-extraction-of-lipase-and-amylase-from-enzyme-mixture-by-employing-liquid-emulsion-membrane
#3
B S Priyanka, Navin K Rastogi
The present work deals with the extraction of lipase and amylase from enzyme mixture by employing liquid emulsion membranes (LEM). The electrostatic interaction between enzymes and reverse micellar surfactant polar head group plays an important role for selective extraction of two different enzymes having different isoelectric points. The optimised conditions for lipase extraction (pH 7.0) resulted in the purification fold and activity recovery of 5.43 fold and 89.53%, respectively, whereas, in case of amylase (pH 9...
February 21, 2018: Biotechnology Progress
https://www.readbyqxmd.com/read/29463814/lem-3-is-a-midbody-tethered-dna-nuclease-that-resolves-chromatin-bridges-during-late-mitosis
#4
Ye Hong, Remi Sonneville, Bin Wang, Viktor Scheidt, Bettina Meier, Alexander Woglar, Sarah Demetriou, Karim Labib, Verena Jantsch, Anton Gartner
Faithful chromosome segregation and genome maintenance requires the removal of all DNA bridges that physically link chromosomes before cells divide. Using C. elegans embryos we show that the LEM-3/Ankle1 nuclease defines a previously undescribed genome integrity mechanism by processing DNA bridges right before cells divide. LEM-3 acts at the midbody, the structure where abscission occurs at the end of cytokinesis. LEM-3 localization depends on factors needed for midbody assembly, and LEM-3 accumulation is increased and prolonged when chromatin bridges are trapped at the cleavage plane...
February 20, 2018: Nature Communications
https://www.readbyqxmd.com/read/29459491/steroid-sulfation-pathways-targeted-by-disulfates-determination-application-to-prenatal-diagnosis
#5
Oscar J Pozo, Josep Marcos, Olha Khymenets, Andy Pranata, Christopher Fitzgerald, Malcolm Donald McLeod, Cedric Shackleton
The steroid disulfates (aka bis-sulfates or bis(sulfates)) are a significant but minor fraction of the urinary steroid metabolome that have not been widely studied because major components are not hydrolyzed by the commercial sulfatases commonly used in steroid metabolomics. In early studies, conjugate fractionation followed by hydrolysis using acidified solvent (solvolysis) was used for the indirect detection of this fraction by GC-MS. This paper describes the application of a specific LC-MS/MS method for the direct identification of disulfates in urine, and their use as markers for the prenatal diagnosis of disorders causing reduced estriol production: STSD (Steroid Sulfatase Deficiency), SLOS (Smith-Lemli-Opitz Syndrome) and PORD (P450 Oxido-Reductase Deficiency)...
February 19, 2018: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29459152/dose-response-curves-for-mri-detected-radiation-induced-temporal-lobe-reactions-in-patients-after-proton-and-carbon-ion-therapy-does-the-same-rbe-weighted-dose-lead-to-the-same-biological-effect
#6
Clarissa Gillmann, Antony J Lomax, Damien C Weber, Oliver Jäkel, Christian P Karger
PURPOSE: To derive the dose-response curve for temporal lobe reactions (TLRs) after proton therapy and to compare the resulting relative biological effectiveness (RBE)-weighted tolerance doses based on an RBE of 1.1 with published values for carbon ions, which were calculated by the two versions of the local effect model (LEM I or IV). METHODS AND MATERIALS: 62 patients treated with protons for skull base tumors were analyzed for TLRs using magnetic resonance imaging...
February 16, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29458066/volitional-voiding-of-the-bladder-following-spinal-cord-injury-validation-of-bilateral-lower-extremity-motor-function-as-a-key-predictor
#7
Christopher S Elliott, Kai B Dallas, Dimitar Zlatev, Craig V Comiter, James Crew, Kazuko Shem
INTRODUCTION: For many with spinal cord injury (SCI), a return of volitional bladder voiding is considered more important than regaining motor function. Recently a predictive model using only composite bilateral lower extremity motor (LEM) scores for levels L2-S1 (range 0-50) was put forth by the European Multicenter Spinal Cord Injury (EMSCI) study group that showed exceptional predictive power with an area under the curve (AUC) of 0.912. We sought to further validate the EMSCI model using a national SCI cohort...
February 16, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29455191/smith-lemli-opitz-syndrome-clinical-and-biochemical-correlates
#8
Sarah E Donoghue, James J Pitt, Avihu Boneh, Susan M White
BACKGROUND: Smith-Lemli-Opitz syndrome (SLOS) is an autosomal recessive disorder caused by mutations in the DHCR7 gene that result in reduced cholesterol biosynthesis. The aim of the study was to examine the biochemical and clinical features of SLOS in the context of the emerging evidence of the importance of cholesterol in morphogenesis and steroidogenesis. METHODS: We retrospectively reviewed the records of 18 patients (including four fetuses) with confirmed SLOS and documented their clinical and biochemical features...
February 19, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29452281/incidence-and-risk-factors-of-post-operative-neurological-decline-after-complex-adult-spinal-deformity-surgery-results-of-the-scoli-risk-1-study
#9
Michael G Fehlings, So Kato, Lawrence G Lenke, Hiroaki Nakashima, Narihito Nagoshi, Christopher I Shaffrey, Kenneth M C Cheung, Leah Carreon, Mark B Dekutoski, Frank J Schwab, Oheneba Boachie-Adjei, Khaled M Kebaish, Christopher P Ames, Yong Qiu, Yukihiro Matsuyama, Benny T Dahl, Hossein Mehdian, Ferran Pellisé-Urquiza, Stephen J Lewis, Sigurd H Berven
BACKGROUND CONTEXT: Significant variability in neurologic outcomes following surgical correction for adult spinal deformity (ASD) has been reported. Risk factors for decline in neurologic motor outcomes are poorly understood. PURPOSE: The objective of the present investigation was to identify the risk factors for post-operative neurological motor decline in patients undergoing complex ASD surgery. STUDY DESIGN/SETTING: A prospective international multicenter cohort study...
February 13, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29439432/complex-formation-of-resorufin-and-resazurin-with-%C3%AE-cyclodextrins-can-cyclodextrins-interfere-with-a-resazurin-cell-viability-assay
#10
Rita Csepregi, Beáta Lemli, Sándor Kunsági-Máté, Lajos Szente, Tamás Kőszegi, Balázs Németi, Miklós Poór
Resazurin (or Alamar Blue) is a poorly fluorescent dye. During the cellular reduction of resazurin, its highly fluorescent product resorufin is formed. Resazurin assay is a commonly applied method to investigate viability of bacterial and mammalian cells. In this study, the interaction of resazurin and resorufin with β-cyclodextrins was investigated employing spectroscopic and molecular modeling studies. Furthermore, the influence of β-cyclodextrins on resazurin-based cell viability assay was also tested...
February 10, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29433144/smith-lemli-opitz-mutations-in-unexplained-stillbirths
#11
Karen J Gibbins, Uma M Reddy, George R Saade, Robert L Goldenberg, Donald J Dudley, Corette B Parker, Vanessa Thorsten, Halit Pinar, Radek Bukowski, Carol J Hogue, Robert M Silver
OBJECTIVE:  Smith-Lemli-Opitz syndrome (SLOS) is an autosomal recessive syndrome caused by a defect in cholesterol biosynthesis with mutations in 7-dehydrocholesterol reductase (DHCR7). A total of 3% of Caucasians carry DHCR7 mutations, theoretically resulting in a homozygote frequency of 1/4000. However, SLOS occurs in only 1/20,000 to 60,000 live births. Our objective was to assess DHCR7 mutations in unexplained stillbirths. STUDY DESIGN:  Prospective, multicenter, population-based case-control study of all stillbirths and a representative sample of live births enrolled in five geographic areas...
February 12, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29427550/clinically-relevant-discrepancies-between-different-rheumatoid-factor-assays
#12
Willem J J Falkenburg, Helen J von Richthofen, Jana Koers, Cas Weykamp, Marco W J Schreurs, Liesbeth E Bakker-Jonges, Inez-Anne Haagen, Willem F Lems, Dörte Hamann, Dirkjan van Schaardenburg, Theo Rispens
BACKGROUND: Accurate measurements of rheumatoid factors (RFs), autoantibodies binding IgG, are important for diagnosing rheumatoid arthritis (RA) and for predicting disease course. Worldwide, various RF assays are being used that differ in technique and target antigens. We studied whether assay choice leads to clinically important discrepancies in RF status and level. METHODS: RF measurements using four commercial RF assays were compared in 32 RF+ samples. Using enzyme-linked immunosorbent assays (ELISAs), the influence of the target antigen source - human IgG (hIgG) versus rabbit IgG (rIgG) - on measured RF levels was investigated in arthralgia patients and RA patients...
February 10, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29402568/3-4-diaminopyridine-for-the-treatment-of-myasthenia-gravis-with-electrophysiological-patterns-of-lambert-eaton-myasthenic-syndrome
#13
Moon Kyu Lee, Il Nam Sunwoo, Seung Min Kim
3,4-Diaminopyridine (34DAP) is a presynaptic transmission enhancer. Its efficacy for Lambert-Eaton myasthenic syndrome (LEMS) and myasthenia gravis (MG) was demonstrated. However, there are cases sharing the characteristics of both disease and the effect of 34DAP in "gray zone" patients is sparse. Recently, we prescribed 34DAP to five anti-acetylcholine receptor antibody-positive MG patients with electrophysiological LEMS patterns and three LEMS patients, and carefully monitored the responses. Sero-positive MG patients exhibited more favorable responses than LEMS patients...
February 2, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29389392/lemmings-into-the-sea-or-back-across-the-bridge-the-fate-of-albumin-in-nephrotic-syndrome
#14
Ora A Weisz, Catherine J Baty
An intact glomerular filtration barrier is essential for maintaining plasma albumin levels. However, the capacity of the proximal tubule to reabsorb filtered albumin and the subsequent fate of this protein are hotly debated. Weyer et al. find that knockout of megalin and cubilin receptors in a nephrotic mouse model causes no further reduction in plasma albumin levels, suggesting that albumin retrieval by the proximal tubule does not contribute significantly to albumin homeostasis.
February 2018: Kidney International
https://www.readbyqxmd.com/read/29382470/diagnostic-implications-of-enumerating-and-reporting-beta-fraction-s-for-the-detection-of-beta-migrating-monoclonal-immunoglobulins-in-serum-protein-electrophoresis
#15
Chan Pak Cheung, Bonny Lem-Ragosnig, Jialun Chen
BACKGROUND: Modern serum protein electrophoresis (SPE) resolves serum proteins in 6 major fractions, splitting beta (B) into beta1 (B1) and beta2 (B2). Beta-migrating monoclonal immunoglobulins (B-MC) commonly integrate into normal-looking peak shape(s) but may increase the fraction value, forming the basis for reflex testing. The objectives of this study were (1) to ascertain the value of beta fraction(s) reporting, and (2) to compare the diagnostic performance between different beta-flagging approaches, particularly ↑B versus ↑B1 and/or ↑B2...
January 27, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29381946/efficacy-and-safety-of-9-nonoperative-regimens-for-the-treatment-of-spinal-cord-injury-a-network-meta-analysis
#16
Da-Nian Ma, Xia-Qi Zhang, Jie Ying, Zhong-Jun Chen, Li-Xin Li
OBJECTIVE: This network meta-analysis aims to compare the efficacy and safety of 9 nonoperative regimens (placebo, pregabalin, GM-1 ganglioside, venlafaxine extended-release [venlafaxine XR], fampridine, conventional over-ground training [OT], body-weight-supported treadmill training [BWSTT], robotic-assisted gait training [RAGT] + OT and body-weight-supported over-ground training [BWSOT]) in treating spinal cord injury (SCI). METHODS: Clinical controlled trials of 9 nonoperative regimens for SCI were retrieved in the electronic database...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29370811/harm-benefit-and-costs-associated-with-low-dose-glucocorticoids-added-to-the-treatment-strategies-for-rheumatoid-arthritis-in-elderly-patients-gloria-trial-study-protocol-for-a-randomised-controlled-trial
#17
Linda Hartman, Linda A Rasch, Thomas Klausch, Hans W J Bijlsma, Robin Christensen, Yvo M Smulders, Stuart H Ralston, Frank Buttgereit, Maurizio Cutolo, Jose A P Da Silva, Daniela Opris, Jozef Rovenský, Szilvia Szamosi, Leonie M Middelink, Willem F Lems, Maarten Boers
BACKGROUND: Rheumatoid arthritis (RA) is a chronic inflammatory disease of the joints affecting 1% of the world population. It has major impact on patients through disability and associated comorbidities. Current treatment strategies have considerably improved the prognosis, but recent innovations (especially biologic drugs and the new class of so-called "JAK/STAT inhibitors") have important safety issues and are very costly. Glucocorticoids (GCs) are highly effective in RA, and could reduce the need for expensive treatment with biologic agents...
January 25, 2018: Trials
https://www.readbyqxmd.com/read/29355488/smith-lemli-opitz-syndrome-in-a-newborn-infant-with-developmental-abnormalities-and-low-endogenous-cholesterol
#18
Yifei Yang, Lindsay Yassan, Edward Ki Yun Leung, Kiang-Teck J Yeo
BACKGROUND: Patients with Smith-Lemli-Opitz Syndrome (SLOS) have defective endogenous cholesterol synthesis, and present with decrease cholesterol levels and multiple developmental dysmorphologies. CASE DESCRIPTION: A newborn infant with normal XY karyotype and normal microarray was born with multiple developmental defects and ambiguous genitalia was diagnosed following biochemical genetic analysis of serum 7-DHC concentrations. The clinical course of the patient was further complicated by the comorbidities associated with SLOS and the bacterial infections...
January 16, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29352199/prevention-of-retinal-degeneration-in-a-rat-model-of-smith-lemli-opitz-syndrome
#19
Steven J Fliesler, Neal S Peachey, Josi Herron, Kelly M Hines, Nadav I Weinstock, Sriganesh Ramachandra Rao, Libin Xu
Smith-Lemli-Opitz Syndrome (SLOS) is a recessive human disease caused by defective cholesterol (CHOL) synthesis at the level of DHCR7 (7-dehydrocholesterol reductase), which normally catalyzes the conversion of 7-dehydrocholesterol (7DHC) to CHOL. Formation and abnormal accumulation of 7DHC and 7DHC-derived oxysterols occur in SLOS patients and in rats treated with the DHCR7 inhibitor AY9944. The rat SLOS model exhibits progressive and irreversible retinal dysfunction and degeneration, which is only partially ameliorated by dietary CHOL supplementation...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29329579/prevalence-and-incidence-of-major-depressive-disorders-among-people-living-with-hiv-residing-in-africa-a-systematic-review-and-meta-analysis-protocol
#20
Jean Joel Bigna, Lewis N Um, Serra Lem Asangbeh, Aurelie T Sibetcheu, Arnaud D Kazé, Jobert Richie Nansseu
BACKGROUND: Depression represents one of the most frequent neuro-psychiatric diseases; it seems to be more prevalent in people living with HIV compared to the general population. However, summarized data in the African setting on the topic are scarce. This systematic review and meta-analysis aims at assessing the prevalence and incidence of major depressive disorders (MDD) in HIV-infected African populations residing in Africa. METHODS AND DESIGN: This review will include observational studies conducted among HIV-infected people residing in Africa, which have reported either the prevalence or incidence of MDD or enough data for its appraisal...
January 12, 2018: Systematic Reviews
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