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https://www.readbyqxmd.com/read/28101369/a-single-gene-controls-leaf-background-color-in-caladium-araceae-and-is-tightly-linked-to-genes-for-leaf-main-vein-color-spotting-and-rugosity
#1
Zhe Cao, Shunzhao Sui, Qian Yang, Zhanao Deng
Modern cultivated caladiums (Caladium×hortulanum) are grown for their long-lasting and colorful leaves. Understanding the mode of inheritance for caladium leaf characteristics is critical for plant breeders to select appropriate parents, predict progeny performance, estimate breeding population sizes needed, and increase breeding efficiencies. This study was conducted to determine the mode of inheritance of two leaf background colors (lemon and green) in caladium and to understand their relationships with four other important leaf characteristics including leaf shape, main vein color, spotting, and rugosity...
2017: Horticulture Research
https://www.readbyqxmd.com/read/28087213/cholesterolomics-an-update
#2
William J Griffiths, Jonas Abdel-Khalik, Eylan Yutuc, Alwena H Morgan, Ian Gilmore, Thomas Hearn, Yuqin Wang
Cholesterolomics can be regarded as the identification and quantification of cholesterol, its precursors post squalene, and metabolites of cholesterol and of its precursors, in a biological sample. These molecules include 1,25-dihydroxyvitamin D3, steroid hormones and bile acids and intermediates in their respective biosynthetic pathways. In this short article we will concentrate our attention on intermediates in bile acid biosynthesis pathways, in particular oxysterols and cholestenoic acids. These molecular classes are implicated in the aetiology of a diverse array of diseases including autoimmune disease, Parkinson's disease, motor neuron disease, breast cancer, the lysosomal storage disease Niemann-Pick type C and the autosomal recessive disorder Smith-Lemli-Opitz syndrome...
January 10, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/28072575/systematics-of-relative-biological-effectiveness-measurements-for-proton-radiation-along-the-spread-out-bragg-peak-experimental-validation-of-the-local-effect-model
#3
Rebecca Grün, Thomas Friedrich, Michael Krämer, Michael Scholz
The purpose of this study is to compare the predictions of the local effect model (LEM) in an extensive analysis to proton relative biological effectiveness (RBE) experiments found in the literature, and demonstrate the capabilities of the model as well as to discuss potential limitations. 19 publications with in vitro experiments and 10 publications with in vivo experiments focusing on proton RBE along the spread out Bragg peak (SOBP) were considered. In total the RBE values of over 100 depth positions were compared to LEM predictions...
February 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28053139/cuff-pressure-pain-detection-is-associated-with-both-sex-and-physical-activity-level-in-nonathletic-healthy-subjects
#4
Dag Lemming, Björn Börsbo, Anna Sjörs, Eva-Britt Lind, Lars Arendt-Nielsen, Thomas Graven-Nielsen, Björn Gerdle
: PURPOSE : The aim of this study was to evaluate pressure pain sensitivity on leg and arm in 98 healthy persons (50 women) using cuff algometry. Furthermore, associations with sex and physical activity level were investigated. METHOD:  Normal physical activity level was defined as Godin Leisure-Time Exercise Questionnaire (GLTEQ) score ≤ 45 and high activity level as GLTEQ > 45. A pneumatic double-chamber cuff was placed around the arm or leg where a single chamber was inflated...
January 4, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28048335/su-g-tep3-13-the-role-of-nanoscale-energy-deposition-in-the-development-of-gold-nanoparticle-enhanced-radiotherapy
#5
C Kirkby, B Koger, N Suchowerska, D McKenzie
PURPOSE: Gold nanoparticles (GNPs) can enhance radiotherapy effects. The high photoelectric cross section of gold relative to tissue, particularly at lower energies, leads to localized dose enhancement. However in a clinical context, photon energies must also be sufficient to reach a target volume at a given depth. These properties must be balanced to optimize such a therapy. Given that nanoscale energy deposition patterns around GNPs play a role in determining biological outcomes, in this work we seek to establish their role in this optimization process...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047315/su-f-t-124-radiation-biological-equivalent-presentations-oflem-1-and-mkm-approaches-in-the-carbon-ion-radiotherapy
#6
W Hsi, G Jiang, Y Sheng
PURPOSE: To study the correlations of the radiation biological equivalent doses (BED) along depth and lateral distance between LEM-1 and MKM approaches. METHODS: In NIRS-MKM (Microdosimetric Kinetic Model) approach, the prescribed BED, referred as C-Eq, doses aims to present the relative biological effectiveness (RBE) for different energies of carbon-ions on a fixed 10% survival value of HCG cell with respect to convention X-ray. Instead of a fixed 10% survival, the BED doses of LEM-1 (Local Effect Model) approach, referred as X-Eq, aims to present the RBE over the whole survival curve of chordoma-like cell with alpha/beta ratio of 2...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047295/tu-h-206-04-an-effective-homomorphic-unsharp-mask-filtering-method-to-correct-intensity-inhomogeneity-in-daily-treatment-mr-images
#7
D Yang, H Gach, H Li, S Mutic
PURPOSE: The daily treatment MRIs acquired on MR-IGRT systems, like diagnostic MRIs, suffer from intensity inhomogeneity issue, associated with B1 and B0 inhomogeneities. An improved homomorphic unsharp mask (HUM) filtering method, automatic and robust body segmentation, and imaging field-of-view (FOV) detection methods were developed to compute the multiplicative slow-varying correction field and correct the intensity inhomogeneity. The goal is to improve and normalize the voxel intensity so that the images could be processed more accurately by quantitative methods (e...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28039416/symptomatic-unilateral-sacroiliitis-as-a-first-presenting-feature-of-igg4-related-disease-with-successful-response-to-treatment-after-1-year-of-follow-uparticle
#8
Anna Jamnitski, Odile van Hall, Niek de Vries, Paul van der Valk, Willem F Lems, Irene E van der Horst-Bruinsma
No abstract text is available yet for this article.
December 30, 2016: Rheumatology
https://www.readbyqxmd.com/read/28029613/a-mems-condenser-microphone-based-intracochlear-acoustic-receiver
#9
Flurin Pfiffner, Lukas Prochazka, Dominik Peus, Ivo Dobrev, Adrian Dalbert, Jae Hoon Sim, Rahel Kesterke, Joris Walraevens, Francesca Paris, Christof Roosli, Dominik Obrist, A M Huber
GOAL: Intracochlear sound pressure (ICSP) measurements are limited by the small dimensions of the human inner ear and the requirements imposed by the liquid medium. A robust intracochlear acoustic receiver (ICAR) for repeated use with a simple data acquisition system that provides the required high sensitivity and small dimensions does not yet exist. The work described in this report aims to fill this gap and presents a new MEMS condenser microphone (CMIC) based ICAR concept suitable for ICSP measurements in human temporal bones...
December 16, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28025886/comparative-analysis-of-the-rats-gut-microbiota-composition-in-animals-with-different-ginsenosides-metabolizing-activity
#10
Wei-Wei Dong, Fang-Ling Xuan, Fei-Liang Zhong, Jun Jiang, Songquan Wu, Donghao Li, Lin-Hu Quan
Following oral intake of Panax ginseng, major ginsenosides are metabolized to deglycosylated ginsenosides by gut microbiota before absorption into the blood. As the composition of gut microbiota varies between individuals, metabolic activities are significantly different. We selected 6 rats with low efficiency metabolism (LEM) and 6 rats with high efficiency metabolism (HEM) from 60 rats following oral administration of Panax ginseng extract, and analyzed their gut microbiota composition using Illumina HiSeq sequencing of the 16S rRNA gene...
January 18, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28007756/eular-efort-recommendations-for-management-of-patients-older-than-50%C3%A2-years-with-a-fragility-fracture-and-prevention-of-subsequent-fractures
#11
W F Lems, K E Dreinhöfer, H Bischoff-Ferrari, M Blauth, E Czerwinski, Jap da Silva, A Herrera, P Hoffmeyer, T Kvien, G Maalouf, D Marsh, J Puget, W Puhl, G Poor, L Rasch, C Roux, S Schüler, B Seriolo, U Tarantino, T van Geel, A Woolf, C Wyers, P Geusens
The European League Against Rheumatism (EULAR) and the European Federation of National Associations of Orthopaedics and Traumatology (EFORT) have recognised the importance of optimal acute care for the patients aged 50 years and over with a recent fragility fracture and the prevention of subsequent fractures in high-risk patients, which can be facilitated by close collaboration between orthopaedic surgeons and rheumatologists or other metabolic bone experts. Therefore, the aim was to establish for the first time collaborative recommendations for these patients...
December 22, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27997683/lambert-eaton-myasthenic-syndrome-lems-epidemiology-and-therapeutic-response-in-the-national-veterans-affairs-va-population
#12
Daniel C Abenroth, A Gordon Smith, John E Greenlee, Sharon D Austin, Stacey L Clardy
INTRODUCTION: One nation-wide study (Netherlands) of LEMS has been published. We report LEMS epidemiology and therapeutic response in the United States Veterans Affairs (VA) population. METHODS: Medical records for all active patients (12.5 million) in the VA health system were queried for relevant ICD-9 codes for 10/1/1999 - 9/30/2013. Clinical, electrophysiologic, and serologic features were evaluated to confirm diagnosis; epidemiologic and treatment data were collected...
December 20, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27979038/baseline-assessment-and-comparison-of-arterial-anatomy-hyperemic-flow-and-skeletal-muscle-perfusion-in-peripheral-artery-disease-the-cardiovascular-cell-therapy-research-network-patients-with-intermittent-claudication-injected-with-aldh-bright-cells-cctrn-pace
#13
Bharath Ambale Venkatesh, Victor Nauffal, Chikara Noda, Tomoki Fujii, Phillip C Yang, Judy Bettencourt, Erin P Ricketts, Michael Murphy, Nicholas J Leeper, Lem Moyé, Ray F Ebert, Raja Muthupillai, David A Bluemke, Emerson C Perin, Alan T Hirsch, João A C Lima
BACKGROUND: Peripheral artery disease (PAD) is important to public health as a major contributor to cardiovascular morbidity and mortality. Recent developments in magnetic resonance imaging (MRI) techniques permit improved assessment of PAD anatomy and physiology, and may serve as surrogate end points after proangiogenic therapies. METHODS: The PACE study is a randomized, double-blind, placebo-controlled clinical trial designed to assess the physiologic impact and potential clinical efficacy of autologous bone marrow-derived ALDH(br) stem cells...
January 2017: American Heart Journal
https://www.readbyqxmd.com/read/27960036/emerin-self-assembly-mechanism-role-of-the-lem-domain
#14
Camille Samson, Florian Celli, Kitty Hendriks, Maximilian Zinke, Nada Essawy, Isaline Herrada, Ana-Andreea Arteni, François-Xavier Theillet, Béatrice Alpha-Bazin, Jean Armengaud, Catherine Coirault, Adam Lange, Sophie Zinn-Justin
At the nuclear envelope, the inner nuclear membrane protein emerin contributes to the interface between the nucleoskeleton and the chromatin. Emerin is an essential actor of the nuclear response to a mechanical signal. Genetic defects in emerin cause Emery-Dreifuss muscular dystrophy. It was proposed that emerin oligomerization regulates nucleoskeleton binding and impaired oligomerization contributes to the loss of function of emerin disease-causing mutants. We here report the first structural characterization of emerin oligomers...
December 13, 2016: FEBS Journal
https://www.readbyqxmd.com/read/27936177/rapid-karyotype-evolution-in-lasiopodomys-involved-at-least-two-autosome-sex-chromosome-translocations
#15
Olga L Gladkikh, Svetlana A Romanenko, Natalya A Lemskaya, Natalya A Serdyukova, Patricia C M O'Brien, Julia M Kovalskaya, Antonina V Smorkatcheva, Feodor N Golenishchev, Polina L Perelman, Vladimir A Trifonov, Malcolm A Ferguson-Smith, Fengtang Yang, Alexander S Graphodatsky
The generic status of Lasiopodomys and its division into subgenera Lasiopodomys (L. mandarinus, L. brandtii) and Stenocranius (L. gregalis, L. raddei) are not generally accepted because of contradictions between the morphological and molecular data. To obtain cytogenetic evidence for the Lasiopodomys genus and its subgenera and to test the autosome to sex chromosome translocation hypothesis of sex chromosome complex origin in L. mandarinus proposed previously, we hybridized chromosome painting probes from the field vole (Microtus agrestis, MAG) and the Arctic lemming (Dicrostonyx torquatus, DTO) onto the metaphases of a female Mandarin vole (L...
2016: PloS One
https://www.readbyqxmd.com/read/27935068/single-fiber-emg-with-concentric-electrodes-in-lambert-eaton-myasthenia
#16
Yuzhou Guan, Qingyun Ding, Mingsheng Liu, Jingwen Niu, Liying Cui
INTRODUCTION: We analyzed jitter recordings made with concentric needle electrode single-fiber EMG (CNE-SFEMG) in Lambert-Eaton myasthenia (LEM). METHODS: Fifteen subjects diagnosed with LEM were studied using CNE-SFEMG in the extensor digitorum (ED) and tibialis anterior (TA) muscles. CNE-SFEMG in the ED and TA was also used to evaluate 12 and 10 healthy controls (HCs), respectively. RESULTS: Ten men and 5 women were diagnosed with LEM based on an increase of 100% in compound muscle action potential (CMAP) amplitude during 50 Hz repetitive nerve stimulation...
December 9, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27931178/chemical-composition-and-cytotoxic-properties-of-clinacanthus-nutans-root-extracts
#17
Peik Lin Teoh, Angelina Ying Fang Cheng, Monica Liau, Fui Fui Lem, Grace P Kaling, Fern Nie Chua, Bo Eng Cheong
CONTEXT: Clinacanthus nutans Lindau (Acanthaceae) is a medicinal plant that has been reported to have anti-inflammatory, antiviral, antimicrobial and antivenom activities. In Malaysia, it has been widely claimed to be effective in various cancer treatments but scientific evidence is lacking. OBJECTIVE: This study investigates the chemical constituents, anti-proliferative, and apoptotic properties of C. nutans root extracts. MATERIALS AND METHODS: The roots were subjected to solvent extraction using methanol and ethyl acetate...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27928217/effects-of-a-high-protein-and-omega-3-enriched-diet-with-or-without-creatine-supplementation-on-markers-of-soreness-and-inflammation-during-5-consecutive-days-of-high-volume-resistance-exercise-in-females
#18
Sara Hayward, Colin D Wilborn, Lem W Taylor, Stacie L Urbina, Jordan J Outlaw, Cliffa A Foster, Michael D Roberts
We examined if two different dietary interventions affected markers of soreness and inflammation over a 5-day high-volume resistance training protocol in females that resistance-trained 8 weeks prior. Twenty-eight females (age: 20 ± 1 yr; body mass: 63.5 ± 1.6 kg, height: 1.67 ± 0.01 m) completed 4 weeks of pre-training (weeks 1-4) followed by a subsequent 4-week training period along with a dietary intervention (weeks 5-8). Dietary interventions from weeks 5-8 included: a) no intervention (CTL, n = 10) b) a higher-protein diet supplemented with hydrolyzed whey protein (50 g/d) and omega-3 fatty acids (900 mg/d) (DI, n = 8), and c) the DI condition as well as creatine monohydrate (5 g/d) (DI+C, n = 10)...
December 2016: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/27922503/myasthenia-gravis-and-lambert-eaton-myasthenic-syndrome
#19
Michael W Nicolle
PURPOSE OF REVIEW: This article discusses the pathogenesis, diagnosis, and management of autoimmune myasthenia gravis (MG) and Lambert-Eaton myasthenic syndrome (LEMS). RECENT FINDINGS: Recognition of new antigenic targets and improved diagnostic methods promise to improve the diagnosis of MG, although the clinical phenotypes associated with newer antibodies have not yet been defined. Future therapies might specifically target the aberrant immune response. The apparent increase in the prevalence of MG is not fully explained...
December 2016: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/27882430/identification-of-cardiovascular-risk-factors-associated-with-bone-marrow-cell-subsets-in-patients-with-stemi-a-biorepository-evaluation-from-the-cctrn-time-and-latetime-clinical-trials
#20
Ariadna Contreras, Aaron F Orozco, Micheline Resende, Robert C Schutt, Jay H Traverse, Timothy D Henry, Dejian Lai, John P Cooke, Roberto Bolli, Michelle L Cohen, Lem Moyé, Carl J Pepine, Phillip C Yang, Emerson C Perin, James T Willerson, Doris A Taylor
Autologous bone marrow mononuclear cell (BM-MNC) therapy for patients with ST-segment elevation myocardial infarction (STEMI) has produced inconsistent results, possibly due to BM-MNC product heterogeneity. Patient-specific cardiovascular risk factors (CRFs) may contribute to variations in BM-MNC composition. We sought to identify associations between BM-MNC subset frequencies and specific CRFs in STEMI patients. Bone marrow was collected from 191 STEMI patients enrolled in the CCTRN TIME and LateTIME trials...
January 2017: Basic Research in Cardiology
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