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https://www.readbyqxmd.com/read/29652818/beneficial-effects-of-different-flavonoids-on-vascular-and-renal-function-in-l-name-hypertensive-rats
#1
M Dolores Paredes, Paola Romecín, Noemí M Atucha, Francisco O'Valle, Julián Castillo, M Clara Ortiz, Joaquín García-Estañ
BACKGROUND: we have evaluated the antihypertensive effect of several flavonoid extracts in a rat model of arterial hypertension caused by chronic administration (6 weeks) of the nitric oxide synthesis inhibitor, L-NAME. METHODS: Sprague Dawley rats received L-NAME alone or L-NAME plus flavonoid-rich vegetal extracts (Lemon, Grapefruit + Bitter Orange, and Cocoa) or purified flavonoids (Apigenin and Diosmin) for 6 weeks. RESULTS: L-NAME treatment resulted in a marked elevation of blood pressure, and treatment with Apigenin, Lemon Extract, and Grapefruit + Bitter Orange extracts significantly reduced the elevated blood pressure of these animals...
April 13, 2018: Nutrients
https://www.readbyqxmd.com/read/29600620/-study-on-difference-of-flavonoids-content-in-stems-and-leaves-of-mentha-haplocalycis-herba-in-different-harvest-periods
#2
Shao-Wei Hu, Kun-Rui Zhong, Jia-Ying Yang, Lei Su, Yan-Yan Jiang, Bin Liu
The dynamic changes of active components in stems and leaves of Mentha Haplocalycis Herba(mint) at different harvest periods were investigated, and the optimum harvest time of mint was explored. In this study, hesperidin, diosmin, didymin and buddleoside were selected as flavonoids index components of mint, and the QAMS method was established to measure the contents of these flavonoids in mint. The contents of 4 flavonoid glycosides in the mint stems and leaves from three habitats harvested in different time were studied and evaluated comprehensively using statistical analysis and principal component analysis (PCA)...
February 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29588131/protective-effects-of-micronized-purified-flavonoid-fraction-mpff-on-a-novel-experimental-model-of-chronic-venous-hypertension
#3
Maria das Graças C de Souza, Fatima Zga Cyrino, Jorge J de Carvalho, Vanessa Blanc-Guillemaud, Eliete Bouskela
OBJECTIVES: To assess protective effects of micronized purified flavonoid fraction (MPFF) on microcirculation in an original chronic model of hind limb venous hypertension with low blood flow in small animals. METHODS: Vein ligatures were performed on male hamsters, as follows: A-right femoral vein; A + B-right femoral vein and its right branch; A + C-right femoral vein and its left branch; A + B + C-right femoral and its right and left branches; D-external right iliac vein...
March 24, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29557724/drug-targeted-virtual-screening-and-molecular-dynamics-of-lipu-protein-of-mycobacterium-tuberculosis-and-mycobacterium-leprae
#4
Gurkamaljit Kaur, Bharati Pandey, Arbind Kumar, Naina Garewal, Abhinav Grover, Jagdeep Kaur
The lipolytic protein LipU was conserved in mycobacterium sp. including M. tuberculosis (MTB LipU) and M. leprae (MLP LipU). The MTB LipU was identified in extracellular fraction and was reported to be essential for the survival of mycobacterium. Therefore to address the problem of drug resistance in pathogen, LipU was selected as a drug target and the viability of finding out some FDA approved drugs as LipU inhibitors in both the cases was explored. Three dimensional (3D) model structures of MTB LipU and MLP LipU were generated and stabilized through molecular dynamics (MD)...
March 20, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29518971/dietary-plants-for-the-prevention-and-management-of-kidney-stones-preclinical-and-clinical-evidence-and-molecular-mechanisms
#5
REVIEW
Mina Cheraghi Nirumand, Marziyeh Hajialyani, Roja Rahimi, Mohammad Hosein Farzaei, Stéphane Zingue, Seyed Mohammad Nabavi, Anupam Bishayee
Kidney stones are one of the oldest known and common diseases in the urinary tract system. Various human studies have suggested that diets with a higher intake of vegetables and fruits play a role in the prevention of kidney stones. In this review, we have provided an overview of these dietary plants, their main chemical constituents, and their possible mechanisms of action. Camellia sinensis (green tea), Rubus idaeus (raspberry), Rubia cordifolia (common madder), Petroselinum crispum (parsley), Punica granatum (pomegranate), Pistacia lentiscus (mastic), Solanum xanthocarpum (yellow-fruit nightshade), Urtica dioica (stinging nettle), Dolichos biflorus ( horse gram ), Ammi visnaga (khella), Nigella sativa (black-cumin), Hibiscus sabdariffa (roselle), and Origanum vulgare (oregano) have received considerable interest based on scientific evidence...
March 7, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29479636/effect-of-diosmin-on-apoptotic-signaling-molecules-in-n-nitrosodiethylamine-induced-hepatocellular-carcinoma-in-experimental-rats
#6
Srinivasan Perumal, Kulanthaivel Langeshwaran, Jayaraman Selvaraj, Rajagopal Ponnulakshmi, B Shyamaladevi, M P Balasubramanian
The aim of the present study was to evaluate the antioxidant and chemopreventive efficiency of diosmin against N-nitrosodiethylamine (NDEA)-induced hepatocarcinogenesis in adult male rats. Rats were classified into four groups as follows: Group I: Control, Group II: NDEA-induced hepatocellular carcinogenic rats, Group III: Cancer-bearing animals treated with diosmin (200 mg/kg/body weight/day) orally for 28 days, Group IV: Control animals treated with diosmin (200 mg/kg/body weight/day) alone for 28 days...
February 26, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29476400/a-novel-aspergillus-oryzae-diglycosidase-that-hydrolyzes-6-o-%C3%AE-l-rhamnosyl-%C3%AE-d-glucoside-from-flavonoids
#7
Mai Ishikawa, Mayu Kawasaki, Yoshihito Shiono, Takuya Koseki
α-L-Rhamnosyl-β-D-glucosidase (rutinosidase) hydrolyzes the glycosidic linkage between the disaccharide 6-O-α-L-rhamnosyl-β-D-glucoside (rutinose) and the aglycone. We identified a hypothetical protein (annotated as AO090012000917) encoded in the Aspergillus oryzae genome that exhibits sequence similarity with Aspergillus niger rutinosidase. The recombinant enzyme was expressed in Pichia pastoris GS115 and purified as a glyco-protein with apparent molecular mass of 65-75 kDa by SDS-PAGE. After N-deglycosylation, we observed a 42- and 40-kDa band, representing proteins before and after N-terminal signal peptide processing, respectively...
February 23, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29345918/anti-inflammatory-and-antioxidant-activities-from-the-basolateral-fraction-of-caco-2-cells-exposed-to-a-rosmarinic-acid-enriched-extract
#8
Marisol Villalva, Laura Jaime, Estela Aguado, Juan Antonio Nieto, Guillermo Reglero, Susana Santoyo
The potential use of Origanum majorana L. as a source of bioavailable phenolic compounds, specifically rosmarinic acid (RA), has been evaluated. Phenolic bioavailability was tested using an in vitro digestion process followed by a Caco-2 cellular model of intestinal absorption. The high-performance liquid chromatography-photodiode array detector-tandem mass spectrometry (HPLC-PAD-MS/MS) analysis showed the main components in the extract were 6-hydroxyluteolin-7-O-glucoside and rosmarinic acid, followed by luteolin-O-glucoside...
February 7, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29258224/the-benefits-of-the-citrus-flavonoid-diosmin-on-human-retinal-pigment-epithelial-cells-under-high-glucose-conditions
#9
Wayne Young Liu, Shorong-Shii Liou, Tang-Yao Hong, I-Min Liu
We investigate diosmin for its effect on the ARPE-19 human retinal pigment epithelial cells exposed to high glucose, a model of diabetic retinopathy (DR). After incubation for 4 days with a normal (5 mmol/L) concentration of D-glucose, ARPE-19 cells were exposed separately to normal or high concentrations of D-glucose (30 mmol/L) with or without diosmin at different concentrations (0.1, 1, 10 μg/mL) for another 48 h. Next, we assessed cell viability, reactive oxygen species (ROS) generation and antioxidant enzyme activities...
December 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29210311/the-role-of-gut-microbiota-in-the-modulation-of-drug-action-a-focus-on-some-clinically-significant-issues
#10
REVIEW
Diego Currò
A healthy gut microbiota is necessary for the normal operation of several body functions, including gastrointestinal sensitivity and motility, lipid and glucid metabolism, immune surveillance, and host behavior. In addition, intestinal bacteria contribute to determining the pharmacological properties of several drugs by producing different drug metabolizing enzymes. Areas covered: Four enzymatic processes are discussed: prodrug activation; drug inactivation; drug deconjugation; and hydrolysis of natural glycosides with further metabolism of released aglycones...
February 2018: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/29187079/anti-inflammatory-antioxidant-and-anti-apoptotic-activity-of-diosmin-in-acetic-acid-induced-ulcerative-colitis
#11
A S Shalkami, Mia Hassan, A G Bakr
Ulcerative colitis (UC) is a chronic inflammatory disease affecting colon. The primary symptoms of UC are diarrhoea with blood and mucus and sometimes associated with pain. AIM: This study aimed to evaluate the effects of diosmin (DIO) on UC. METHODS: UC was induced in rats by rectal administration of acetic acid (AA). The degree of mucosal ulceration and damage was determined by evaluating the disease activity index (DAI) and colon damage index scores. Inflammation, oxidative stress and apoptotic responses were determined by measuring the levels of tumour necrosis factor-α (TNF-α), cyclooxygenase-2 (COX-II), malondialdehyde (MDA) and reduced glutathione (GSH) in addition to myeloperoxidase (MPO) activity and caspase-3 expression...
January 2018: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29134244/modulation-of-cyp3a-enzyme-activity-by-diosmin-and-its-consequence-on-carbamazepine-pharmacokinetics-in-rats
#12
Satish Kumar Bedada, Prasad Neerati
Diosmin is a widely used flavonoid for the treatment of varicose veins and hemorrhoids. Epileptic patients with hemorrhoids and varicose veins may use diosmin along with carbamazepine (CBZ) therapy, which leads to pharmacokinetic interaction between diosmin and CBZ. Therefore, the present study was performed to evaluate the effect of diosmin on the pharmacokinetics of CBZ in rats. Diosmin-mediated altered CYP3A enzyme activity in human and rat liver microsomes was examined using CYP3A dependent erythromycin N-demethylase assay...
February 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29126754/effect-of-pulsed-therapeutic-ultrasound-and-diosmin-on-skeletal-muscle-oxidative-parameters
#13
Luis Fernando Sousa Filho, Paula P Menezes, Dayanne Valéria Soares Santana, Bruno S Lima, Shanmugan Saravanan, Grace Kelly M Almeida, José Evaldo R Menezes Filho, Marta M B Santos, Adriano Antunes S Araújo, Evaleide Diniz de Oliveira
Cyclodextrins (CDs) have been widely used as a promising alternative in the formation of inclusion complexes with poorly soluble molecules. From this perspective, the present study aimed to study the inclusion complexes of diosmin in β-cyclodextrin, chemically quantify the diosmin-in-gel preparation and analyze the stability of the gels. Furthermore, we evaluated the effect of therapeutic pulsed ultrasound (TPU) in association with the gel-diosmin complex on the parameters of muscle damage and oxidative stress in rats...
February 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29119110/a-randomized-controlled-trial-evaluating-the-effects-of-diosmin-in-the-treatment-of-radicular-pain
#14
Yinhe Wang, Xin Fang, Lei Ye, Yishan Li, Hongfei Shi, Yang Cao
Diosmin has been widely used to treat patients with vascular pain for its potent anti-inflammatory and analgesic effects. To evaluate the therapeutic effects of Diosmin in the treatment of radicular pain, we conducted an investigator-initiated, randomized, active-controlled noninferiority trial between January 1, 2009, and December 1, 2010. Diosmin (50 mg/kg/day) was orally administered to treat the radicular pain in 150 patients for one month. Another 150 patients with the same symptom were given 20% 250 ml mannitol (1 g/kg/day) for 7 days and dexamethasone (10 mg/day) for 3 days intravenously guttae...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29100118/in-vitro-effects-of-diosmin-naringenin-quercetin-and-indole-3-carbinol-on-fish-hepatic-cyp1a1-in-the-presence-of-clotrimazole-and-dexamethasone
#15
Sidika Sakalli, Viktoriia Burkina, Nadezhda Pilipenko, Vladimir Zlabek, Galia Zamaratskaia
Phytochemicals are widely present in fruits, vegetables and other plants and have great health benefits owing to their antioxidant properties. They are naturally found in the aquatic environment as well as discharged from sewage treatment plants after their large consumption. Little is known about their impact on fish; particularly in light of their interactions with pharmaceuticals. Therefore, this study was designed to determine the effects of diosmin, naringenin, quercetin and idole-3-carbinol on CYP1A-dependent 7-ethoxyresorufin-O-deethylase (EROD) activity on rainbow trout hepatic microsomes in the presence of two pharmaceuticals: clotrimazole and dexamethasone...
February 2018: Chemosphere
https://www.readbyqxmd.com/read/29091880/central-and-peripheral-anti-hyperalgesic-effects-of-diosmin-in-a-neuropathic-pain-model-in-rats
#16
Azucena Ibeth Carballo-Villalobos, María Eva González-Trujano, Francisco Pellicer, Noé Alvarado-Vásquez, Francisco Javier López-Muñoz
Flavonoids are natural compounds showing anti-hyperalgesic activity in models of pain. Diosmin is a compound poorly studied in the treatment of neuropathic pain. This study evaluates the anti-hyperalgesic actions of diosmin and possible mechanisms of action involved by using a neuropathic pain model in rats. Experimental neuropathic pain was induced by chronic constriction injury (CCI) in male Wistar rats, then aesthesiometric index and plantar tests were assessed to evaluate mechanical and thermal hyperalgesia, respectively, in order to explore the analgesic effects of acute and sub-chronic treatment with diosmin...
January 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29036797/effects-of-venotonic-drugs-on-the%C3%A2-microcirculation-comparison-between-ruscus-extract-and-micronized-diosmine1
#17
Fatima Zely Garcia de Almeida Cyrino, Daniela Signorelli Balthazar, Fernando Lencastre Sicuro, Eliete Bouskela
BACKGROUND: Chronic venous disease of the lower limbs is a common public health problem worldwide with negative impact on quality of life and results with drugs used to treat it are sparse, probably due to lack of good experimental models. OBJECTIVE: In this investigation we have tested the effects of two commonly used venotonic substances, Ruscus extract and micronized diosmine, on the microcirculation in vivo. METHODS: These substances were given orally, by gavage, during two weeks, twice daily and observations were made using the hamster cheek pouch preparation...
October 7, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28988357/the-effects-of-diosmin-on-aflatoxin-induced-liver-and-kidney-damage
#18
Gökhan Eraslan, Zeynep Soyer Sarıca, Latife Çakır Bayram, Muhammet Yasin Tekeli, Murat Kanbur, Mürsel Karabacak
Aflatoxin is among the natural toxins that cause serious side effects on living things. Diosmin is also one of the compounds with broad pharmacological effects. In this study, the effects on the oxidant/antioxidant system of 50 mg/kg body weight/day dose of diosmin, aflatoxin (500 μg/kg body weight/day), and combined aflatoxin (500 μg/kg body weight/day) plus diosmin (50 mg/kg body weight/day) given to the stomach via catheter female adult Wistar Albino rats is examined. Forty rats were used in the experiment, and these animals were randomly allocated to four equal groups...
December 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28862211/diosmin-reduces-cell-viability-of-a431-skin-cancer-cells-through-apoptotic-induction
#19
Rajamanickam Buddhan, Shanmugam Manoharan
OBJECTIVES: Aim of the present study was to evaluate the in vitro cytotoxic potential of the diosmin in A431 skin cancer cells. MATERIALS AND METHODS: The cytotoxic (anti-cell proliferative) potential of diosmin in A431 cells was assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay (cell viability), dual staining (apoptotic induction), dichloro-dihydro-fluorescein diacetate assay (reactive oxygen species [ROS] generation), DNA fragmentation study, Western blotting analysis (apoptotic markers expression) and flow cytometry (cell cycle arrest)...
July 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28846859/diosmin-ameliorates-the-effects-of-oxidative-stress-in-lenses-of-streptozotocin-induced-type-1-diabetic-rats
#20
Weronika Wojnar, Ilona Kaczmarczyk-Sedlak, Maria Zych
BACKGROUND: Diabetic cataractogenesis is a complex process connected with hyperglycemia and oxidative stress. Free radicals induce many unfavorable changes in the activity of the antioxidative enzymes and may also lead to oxidative damage. Since diosmin, a plant-derived flavonoid, reveals antioxidative activity, the aim of the study was to investigate if this substance may counteract the oxidative stress in the lenses of diabetic rats. METHODS: The study was conducted on the male Wistar rats with streptozotocin-induced type 1 diabetes...
April 15, 2017: Pharmacological Reports: PR
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