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https://www.readbyqxmd.com/read/26262589/predictors-for-surgical-referral-in-patients-with-pancreatic-cystic-lesions-undergoing-endoscopic-ultrasound-results-from-a-large-multicenter-cohort-study
#1
MULTICENTER STUDY
Phillip S Ge, Srinivas Gaddam, Joseph W Keach, Daniel Mullady, Norio Fukami, Steven A Edmundowicz, Riad R Azar, Raj J Shah, Faris M Murad, Vladimir M Kushnir, Kourosh F Ghassemi, Alireza Sedarat, Rabindra R Watson, Stuart K Amateau, Brian C Brauer, Roy D Yen, Lindsay Hosford, Thomas Hollander, Timothy R Donahue, Richard D Schulick, Barish H Edil, Martin D McCarter, Csaba Gajdos, Augustin R Attwell, V Raman Muthusamy, Dayna S Early, Sachin Wani
OBJECTIVE: Endoscopic ultrasound (EUS) plays an integral role in the evaluation of pancreatic cysts lesions (PCLs). The aim of the study was to determine predictors of surgical referral in patients with PCLs undergoing EUS. METHODS: We performed a multicenter retrospective study of patients undergoing EUS for evaluation of PCLs. Demographics, EUS characteristics, and fine-needle aspiration results were recorded. Patients were categorized into surgery or surveillance groups on the basis of post-EUS recommendations...
January 2016: Pancreas
https://www.readbyqxmd.com/read/26077458/suboptimal-accuracy-of-carcinoembryonic-antigen-in-differentiation-of-mucinous-and-nonmucinous-pancreatic-cysts-results-of-a-large-multicenter-study
#2
MULTICENTER STUDY
Srinivas Gaddam, Phillip S Ge, Joseph W Keach, Daniel Mullady, Norio Fukami, Steven A Edmundowicz, Riad R Azar, Raj J Shah, Faris M Murad, Vladimir M Kushnir, Rabindra R Watson, Kourosh F Ghassemi, Alireza Sedarat, Srinadh Komanduri, Diana-Marie Jaiyeola, Brian C Brauer, Roy D Yen, Stuart K Amateau, Lindsay Hosford, Thomas Hollander, Timothy R Donahue, Richard D Schulick, Barish H Edil, Martin McCarter, Csaba Gajdos, Augustin Attwell, V Raman Muthusamy, Dayna S Early, Sachin Wani
BACKGROUND AND AIMS: The exact cutoff value at which pancreatic cyst fluid carcinoembryonic antigen (CEA) level distinguishes pancreatic mucinous cystic neoplasms (MCNs) from pancreatic nonmucinous cystic neoplasms (NMCNs) is unclear. The aim of this multicenter retrospective study was to evaluate the diagnostic accuracy of cyst fluid CEA levels in differentiating between MCNs and NMCNs. METHODS: Consecutive patients who underwent EUS with FNA at 3 tertiary care centers were identified...
December 2015: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/26062046/characteristics-of-10-year-survivors-of-pancreatic-ductal-adenocarcinoma
#3
Alessandro Paniccia, Patrick Hosokawa, William Henderson, Richard D Schulick, Barish H Edil, Martin D McCarter, Csaba Gajdos
IMPORTANCE: To our knowledge, this study reports on the largest cohort of long-term survivors (LTSs) (≥10 years) following a diagnosis of pancreatic ductal adenocarcinoma (PADC) and identifies the characteristics associated with LTS. OBJECTIVE: To determine patient, tumor, surgical, and sociodemographic characteristics associated with LTS. DESIGN, SETTING, AND PARTICIPANTS: A nationwide retrospective cohort study of patients with invasive PADC (International Classification of Diseases for Oncology, Third Edition codes 8140/3, 8500/3, 8021/3, and 8035/3) was conducted using data collected in the National Cancer Database (NCDB)...
August 2015: JAMA Surgery
https://www.readbyqxmd.com/read/25501072/neoadjuvant-folfirinox-application-in-borderline-resectable-pancreatic-adenocarcinoma-a-retrospective-cohort-study
#4
Alessandro Paniccia, Barish H Edil, Richard D Schulick, Joshua T Byers, Cheryl Meguid, Csaba Gajdos, Martin D McCarter
5-Fluorouracile, oxaliplatin, irinotecan, and leucovorin (FOLFIRINOX) has not been extensively used in the neoadjuvant setting because of concerns with safety and toxicity. We evaluated our institutional experience with neoadjuvant FOLFIRINOX in borderline resectable pancreatic adenocarcinoma (BRPAC). The primary endpoints were completion of therapy to surgery and negative resection margin (R0) rate. Patients with BRPAC treated with neoadjuvant FOLFIRINOX were retrospectively analyzed. Between August 2011 and September 2013, 20 patients with BRPAC treated with neoadjuvant FOLFIRINOX were identified...
December 2014: Medicine (Baltimore)
https://www.readbyqxmd.com/read/24530986/bladder-cancer-exosomes-contain-edil-3-del1-and-facilitate-cancer-progression
#5
Carla J Beckham, Jayme Olsen, Peng-Nien Yin, Chia-Hao Wu, Huei-Ju Ting, Fred K Hagen, Emelian Scosyrev, Edward M Messing, Yi-Fen Lee
PURPOSE: High grade bladder cancer is an extremely aggressive malignancy associated with high rates of morbidity and mortality. Understanding how exosomes may affect bladder cancer progression could reveal novel therapeutic targets. MATERIALS AND METHODS: Exosomes derived from human bladder cancer cell lines and the urine of patients with high grade bladder cancer were assessed for the ability to promote cancer progression in standard assays. Exosomes purified from the high grade bladder cancer cell line TCC-SUP and the nonmalignant urothelial cell line SV-HUC were submitted for mass spectrometry analysis...
August 2014: Journal of Urology
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