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Jiraphorn Issara-Amphorn, Saowapha Surawut, Navaporn Worasilchai, Arthid Thim-Uam, Malcolm Finkelman, Ariya Chindamporn, Tanapat Palaga, Nattiya Hirankarn, Prapaporn Pisitkun, Asada Leelahavanichkul
We investigated the influence of spontaneous gut leakage upon polymicrobial sepsis in a lupus model with Fc gamma receptor IIb-deficient (FcGRIIb-/-) mice aged 8 and 40 weeks, as representing asymptomatic and symptomatic lupus, respectively. Spontaneous gut leakage, determined by (i) the presence of FITC-dextran, (ii) elevated serum endotoxin, and (iii) elevated serum (1→3)-β-D-glucan (BG), was demonstrated in symptomatic lupus but not in the asymptomatic group. In parallel, spontaneous gut leakage, detected by elevated serum BG without fungal infection, was demonstrated in patients with active lupus nephritis...
January 31, 2018: Journal of Innate Immunity
Marianna Stamou, Ana Cristina Grodzki, Marc van Oostrum, Bernd Wollscheid, Pamela J Lein
BACKGROUND: Exposure of the developing brain to immune mediators, including antibodies, is postulated to increase risk for neurodevelopmental disorders and neurodegenerative disease. It has been suggested that immunoglobulin G-immune complexes (IgG-IC) activate Fc gamma receptors (FcγR) expressed on neurons to modify signaling events in these cells. However, testing this hypothesis is hindered by a paucity of data regarding neuronal FcγR expression and function. METHODS: FcγR transcript expression in the hippocampus, cortex, and cerebellum of neonatal male and female rats was investigated ex vivo and in mixed cultures of primary hippocampal and cortical neurons and astrocytes using quantitative PCR analyses...
January 6, 2018: Journal of Neuroinflammation
Yi Shi, Ci-Qiu Yang, Si-Wen Wang, Wen Li, Jie Li, Shen-Ming Wang
OBJECTIVE: To evaluate protein profiles and Fc gamma receptor IIb (FCGRIIB) expression in abdominal aortic aneurysm (AAA) compared to the expression in normal aortas. METHODS: We performed a protein array to study the protein expression profiles within AAA and normal aortic tissues. FCGRIIB was found to be significantly elevated in AAA samples. Quantitative PCR and Western blot analyses were performed to study the expression of FCGRIIB in AAA compared to that in normal aortic tissue...
April 1, 2017: Biochemical and Biophysical Research Communications
S Esnault, M W Johansson, E A Kelly, L Koenderman, D F Mosher, N N Jarjour
BACKGROUND: Eosinophils contribute to the pathogenesis of multiple diseases, including asthma. Treatment with antibodies targeting IL-5 or IL-5 receptor α reduces the frequency of asthma exacerbations. Eosinophil receptors for IL-5 share a common ß-chain with IL-3 and GM-CSF receptors. We recently reported that IL-3 is more potent than IL-5 or GM-CSF in maintaining the ERK/p90S6K/RPS6 ribosome-directed signaling pathway, leading to increased protein translation. OBJECTIVE: We aimed to determine disease-relevant consequences of prolonged eosinophil stimulation with IL-3...
April 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Thunnicha Ondee, Saowapha Surawut, Sujittra Taratummarat, Nattiya Hirankarn, Tanapat Palaga, Prapaporn Pisitkun, Trairak Pisitkun, Asada Leelahavanichkul
Hyper-elevated immune response of FcGRIIb-/- mice, a lupus model with an inhibitory-signaling defect, can become exhausted (less subsequent immune-response than the first response) with sequential lipopolysaccharide (LPS) stimulation. Endotoxin tolerance-related modifications of inflammatory response were investigated in FcGRIIb-/- mice in both an in vivo sepsis model and in vitro using cultured macrophages. Serum cytokine concentrations, after the second LPS injection (at 5-fold higher levels than the first dose), did not exceed the first dose levels in either FcGRIIb-/- or wild-type mice...
June 2017: Shock
Hyoju Yi, Kwi Young Kang, Youngkyun Kim, Hyerin Jung, Yeri Alice Rim, Narae Park, Juryun Kim, Seung Min Jung, Sung-Hwan Park, Ji Hyeon Ju
BACKGROUND: Adipose-derived stem cells (ASCs) are mesenchymal stem cells (MSCs) derived from adipose tissue. MSCs have multiple properties including anti-inflammatory and immunomodulatory effects in various disease models and human diseases. However, the mechanisms underlying this wide range of effects need to be explored. METHODS: Collagen antibody-induced arthritis (CAIA) is a unique model in which arthritis is rapidly and strongly induced. ASCs were intraperitoneally infused into CAIA mice before or after arthritis induction...
2015: BMC Musculoskeletal Disorders
Begoña Pineda, Eva Serna, Andrés Laguna-Fernández, Inmaculada Noguera, Layla Panach, Carlos Hermenegildo, Juan J Tarín, Antonio Cano, Miguel Ángel García-Pérez
Osteoporosis is a multifactorial skeletal pathology with a main genetic component. To date, however, the majority of genes associated with this pathology remain unknown since genes cataloged to date only explain a part of the heritability of bone phenotypes. In the present study, we have used a genome-wide gene expression approach by means of microarrays to identify new candidate genes involved in the physiopathology of osteoporosis, using as a model the ovariectomized (OVX) mice by comparing global bone marrow gene expression of the OVX mice with those of SHAM operated mice...
August 2014: Bone
Jorge Gaona, Carlos Santiago-Olivares, Enrique Ortega, Beatriz Gómez
Viruses can persist in differentiated cells (i.e., macrophages) over long periods of time, altering host cells functions but not inducing their death. We had previously reported that, in early passages (14-40) of a murine macrophage-like cell line persistently infected with respiratory syncytial virus (RSV) (MfP), FcgR-mediated phagocytosis and expression of FcgRIIB/RIII on the cell membrane were increased with respect to mock-infected macrophages (MfN). In this work, we explored the mechanism underlying such effects...
February 2014: Viruses
Daniel Szili, Marcell Cserhalmi, Zsuzsanna Bankó, Gyorgy Nagy, David E Szymkowski, Gabriella Sármay
BACKGROUND AND OBJECTIVES: CD19 is a B cell-specific marker present on pre-B cells, immature and mature B cells but lacking on plasma cells. CD19 is a positive co-receptor of B cell receptors (BCR) and a target of the tyrosine kinase Lyn in activated B cells. Phosphorylated CD19 recruits Lyn, PI3K and Vav, enhancing B cell activation. In contrast, FcgRIIb is also a target of Lyn, but when co-engaged with BCR is phosphorylated, recruits SHP2 and SHIP phosphatases, and inhibits B cell activation...
March 1, 2014: Annals of the Rheumatic Diseases
Ian Dransfield
In this issue of Blood, Vaughan et al demonstrate that certain antibodies that are used therapeutically in lymphoma treatment (e.g., rituximab) undergo Fcg receptor IIb (FcgRIIb)–mediated internalization from the B-cell surface in a manner that is independent of activation of FcgRIIb with important implications for the design of antibody-based therapeutics (see figure).
January 30, 2014: Blood
Zhong Wu, Jin Zhou, Pankaj Prsoon, Xiaoxia Wei, Xiaojing Liu, Bing Peng
Immune thrombocytopenia (ITP) is an autoimmune disorder described as autoantibody-mediated platelet deterioration. Platelets with affiliated IgG are targeted for exploitation by Fc receptor-mediated phagocytic cellular material within the reticuloendothelial system. The objective of this research is to investigate the relationship between the appearance of FC gamma receptors (FCGR) IIB and IIIA on macrophages and clinicopathological characteristics in ITP patients. FCGRIIB and FCGRIIIA were recognized by immunohistochemistry staining of 62 samples, including regular (n = 20) and ITP (n = 42) samples...
November 2012: International Journal of Hematology
Takashi Hashimoto, Norito Ishii, Chika Ohata, Minao Furumura
Autoimmune bullous diseases (ABDs) are organ-specific autoimmune diseases, in which blisters on the skin and mucous membranes develop through binding of pathogenic autoantibodies to target antigens. There are two major ABD groups: the pemphigus group, showing autoantibodies to desmosomal components; and the subepidermal ABD group, showing autoantibodies to hemidesmosomal components in the epidermal basement membrane zone. Recent immunological, biochemical and molecular biological studies revealed many new autoantigens, including desmocollins, various plakin family proteins and integrins...
September 2012: Journal of Pathology
G Zandman-Goddard, M Blank, Y Shoenfeld
This article is an update on the clinical and research data available on systemic lupus erythematosus (SLE) and intravenous immunoglobulin (IVIg) therapy that includes some studies performed under the umbrella of the European Working Party on SLE. Various mechanisms of IVIg may play a role, some synergistically, in the modulation of SLE. Recently it has been suggested that IVIg also suppresses the expansion of autoreactive B lymphocytes through signalling of the FcgRIIB, idiotype-mediated inhibition of B cell receptors and neutralisation of cytokines such as the B cell survival factors (B cell activation factor (BAFF and APRIL)...
September 2009: Lupus
Tracy L McGaha, Brian Sorrentino, Jeffrey V Ravetch
Lupus, a multigenic autoimmune condition in which a breakdown of tolerance results in the development of autoantibodies, leads to a variety of pathologic outcomes. Despite the heterogeneity of factors influencing disease susceptibility, we demonstrate that the partial restoration of inhibitory Fc receptor (FcgRIIB) levels on B cells in lupus-prone mouse strains is sufficient to restore tolerance and prevent autoimmunity. FcgRIIB regulates a common B cell checkpoint in genetically diverse lupus-prone mouse strains, and modest changes in its expression can result in either tolerance or autoimmunity...
January 28, 2005: Science
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