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https://www.readbyqxmd.com/read/28806703/nox4-mediated-ros-production-induces-apoptotic-cell-death-via-down-regulation-of-c-flip-and-mcl-1-expression-in-combined-treatment-with-thioridazine-and-curcumin
#1
Seung Un Seo, Tae Hwan Kim, Dong Eun Kim, Kyoung-Jin Min, Taeg Kyu Kwon
Thioridazine is known to have anti-tumor effects by inhibiting PI3K/Akt signaling, which is an important signaling pathway in cell survival. However, thioridazine alone does not induce apoptosis in head and neck squamous cell carcinoma (AMC-HN4), human breast carcinoma (MDA-MB231), and human glioma (U87MG) cells. Therefore, we investigated whether combined treatment with thioridazine and curcumin induces apoptosis. Combined treatment with thioridazine and curcumin markedly induced apoptosis in cancer cells without inducing apoptosis in human normal mesangial cells and human normal umbilical vein cells (EA...
August 9, 2017: Redox Biology
https://www.readbyqxmd.com/read/28800131/atg2a-b-deficiency-switches-cytoprotective-autophagy-to-non-canonical-caspase-8-activation-and-apoptosis
#2
Zhenyuan Tang, Yoshinori Takahashi, Chong Chen, Ying Liu, Haiyan He, Nikolaos Tsotakos, Jacob M Serfass, Melat T Gebru, Han Chen, Megan M Young, Hong-Gang Wang
Autophagosomal membranes are emerging as platforms for various cell survival and death signaling networks beyond autophagy. While autophagy-dependent cell death has been reported in response to a variety of stimuli, the underlying molecular mechanisms remain far from clear. Here, we demonstrate that inhibition of autophagosome completion by Atg2A/B deletion accumulates immature autophagosomal membranes that promote non-canonical caspase-8 activation in response to nutrient starvation via an intracellular death-inducing signaling complex (iDISC)...
August 11, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28799669/choosing-the-appropriate-shangring-size-for-paediatric-circumcision-using-the-no-flip-technique
#3
Li Fang, Weichao Zhu, Zhongfei Xie, Kerong Wu, Guoyao Wang, Zejun Yan, Zhong Zheng, Qi Ma, Yue Cheng
AIM: To determine the correct ShangRing size for paediatric circumcision using the no-flip technique. METHODS: A cohort of 104 boys (from 6 to 14 years) underwent ShangRing circumcision at Ningbo First Hospital, China. The patients were randomly divided into three groups according to the different methods used for choosing the ring size. For Group A, the ring size was chosen using the ShangRing measuring tape; for Group B, ring size was chosen based on the diameter of penis measured using a self-designed scale plate; and for Group C, ring size was chosen based on the diameter of the glans measured using the self-designed scale plate...
August 11, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28799210/whole-brain-arteriography-and-venography-using-improved-velocity-selective-saturation-pulse-trains
#4
Wenbo Li, Feng Xu, Michael Schär, Jing Liu, Taehoon Shin, Yansong Zhao, Peter C M van Zijl, Bruce A Wasserman, Ye Qiao, Qin Qin
PURPOSE: To develop velocity-selective (VS) MR angiography (MRA) protocols for arteriography and venography with whole-brain coverage. METHODS: Tissue suppression using velocity-selective saturation (VSS) pulse trains is sensitive to radiofrequency field (B1 +) inhomogeneity. To reduce its sensitivity, we replaced the low-flip-angle hard pulses in the VSS pulse train with optimal composite (OCP) pulses. Additionally, new pulse sequences for arteriography and venography were developed by placing spatially selective inversion pulses with a delay to null signals from either venous or arterial blood...
August 10, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28797739/mb-swift-functional-mri-during-deep-brain-stimulation-in-rats
#5
Lauri J Lehto, Djaudat Idiyatullin, Jinjin Zhang, Lynn Utecht, Gregor Adriany, Michael Garwood, Olli Gröhn, Shalom Michaeli, Silvia Mangia
Recently introduced 3D radial MRI pulse sequence entitled Multi-Band SWeep Imaging with Fourier Transformation (MB-SWIFT) having inherently zero acquisition delay was used to obtain functional MRI (fMRI) contrast in rat's brain at 9.4 Tesla during deep brain stimulation (DBS). The results demonstrate that MB-SWIFT allows images free of susceptibility artefacts, and provides an excellent fMRI activation contrast in the brain. Flip angle dependence of the MB-SWIFT fMRI signal and elimination of the fMRI contrast while using saturation bands, indicate a blood flow origin of the observed fMRI contrast...
August 7, 2017: NeuroImage
https://www.readbyqxmd.com/read/28796308/technical-note-the-effect-of-2d-excitation-profile-on-t1-measurement-accuracy-using-the-variable-flip-angle-method-with-an-average-flip-angle-assumption
#6
Bryant T Svedin, Dennis L Parker
PURPOSE: To study the accuracy and precision of T1 estimates using the Variable Flip Angle (VFA) method in 2D and 3D acquisitions. METHODS: Excitation profiles were simulated using numerical implementation of the Bloch equations for Hamming-windowed sinc excitation pulses with different time-bandwidth products (TBP) of 2, 6, and 10 and for T1 values of 295 ms and 1045 ms. Experimental data was collected in 5° increments from 5° to 90° for the same T1 and TBP values...
August 10, 2017: Medical Physics
https://www.readbyqxmd.com/read/28795159/spin-flip-statistics-and-spin-wave-interference-patterns-in-ising-ferromagnetic-films-a-monte-carlo-study
#7
Muktish Acharyya
The spin wave interference is studied in two dimensional Ising ferromagnet driven by two coherent spherical magnetic field waves by Monte Carlo simulation. The spin waves are found to propagate and interfere according to the classic rule of interference pattern generated by two point sources. The interference pattern of spin wave is observed in one boundary of the lattice. The interference pattern is detected and studied by spin flip statistics at high and low temperatures. The destructive interference is manifested as the large number of spin flips and vice versa...
July 2017: Heliyon
https://www.readbyqxmd.com/read/28793989/early-enteral-tube-feeding-in-optimizing-treatment-of-hyperemesis-gravidarum-the-maternal-and-offspring-outcomes-after-treatment-of-hyperemesis-by-refeeding-mother-randomized-controlled-trial
#8
Iris J Grooten, Marjette H Koot, Joris Am van der Post, Joke Mj Bais, Carrie Ris-Stalpers, Christiana Naaktgeboren, Henk A Bremer, David P van der Ham, Wieteke M Heidema, Anjoke Huisjes, Gunilla Kleiverda, Simone Kuppens, Judith Oeh van Laar, Josje Langenveld, Flip van der Made, Mariëlle G van Pampus, Dimitri Papatsonis, Marie-José Pelinck, Paula J Pernet, Leonie van Rheenen, Robbert J Rijnders, Hubertina Cj Scheepers, Tatjana E Vogelvang, Ben W Mol, Tessa J Roseboom, Rebecca C Painter
Background: Hyperemesis gravidarum (HG) leads to dehydration, poor nutritional intake, and weight loss. HG has been associated with adverse pregnancy outcomes such as low birth weight. Information about the potential effectiveness of treatments for HG is limited.Objective: We hypothesized that in women with HG, early enteral tube feeding in addition to standard care improves birth weight.Design: We performed a multicenter, open-label randomized controlled trial [Maternal and Offspring outcomes after Treatment of HyperEmesis by Refeeding (MOTHER)] in 19 hospitals in the Netherlands...
August 9, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28790966/randomized-controlled-study-of-a-remote-flipped-classroom-neuro-otology-curriculum
#9
Frederick Robert Carrick, Mahera Abdulrahman, Ahmed Hankir, Maksim Zayaruzny, Kinda Najem, Palita Lungchukiet, Roger A Edwards
CONTEXT: Medical Education can be delivered in the traditional classroom or via novel technology including an online classroom. OBJECTIVE: To test the hypothesis that learning in an online classroom would result in similar outcomes as learning in the traditional classroom when using a flipped classroom pedagogy. DESIGN: Randomized controlled trial. A total of 274 subjects enrolled in a Neuro-otology training program for non-Neuro-otologists of 25 h held over a 3-day period...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28790121/cardiovascular-magnetic-resonance-relaxometry-predicts-regional-functional-outcome-after-experimental-myocardial-infarction
#10
Sebastian M Haberkorn, Christoph Jacoby, Zhaoping Ding, Petra Keul, Florian Bönner, Amin Polzin, Bodo Levkau, Jürgen Schrader, Malte Kelm, Ulrich Flögel
BACKGROUND: Cardiovascular magnetic resonance with gadolinium-based contrast agents has established as gold standard for tissue characterization after myocardial infarction (MI). Beyond accurate diagnosis, the value of cardiovascular magnetic resonance to predict the outcome after MI has yet to be substantiated. METHODS AND RESULTS: Recent cardiovascular magnetic resonance approaches were systematically compared for quantification of tissue injury and functional impairment after MI using murine models with permanent left anterior descending coronary artery ligation (n=14) or 50 minutes ischemia/reperfusion (n=13)...
August 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28782749/gall-bladder-flip-technique-in-laparoscopic-cholecystectomy
#11
Munish Sharma, Anubhav Vindal, Pawanindra Lal
BACKGROUND: The precise steps for the removal of gall bladder from the gall bladder bed are not well standardised. The dissection becomes more difficult near the fundus where the assistant's grasper holding the fundus creates a 'tug of war' like situation. MATERIALS AND METHODS: This is a description of a simple technique that aids in accurate dissection of the gallbladder from liver bed. As the gallbladder dissection approaches fundus and more than two-third of gallbladder is dissected from liver bed, the medial and lateral peritoneal folds of gall bladder are further incised...
August 1, 2017: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/28782025/observation-of-ultralong-valley-lifetime-in-wse2-mos2-heterostructures
#12
Jonghwan Kim, Chenhao Jin, Bin Chen, Hui Cai, Tao Zhao, Puiyee Lee, Salman Kahn, Kenji Watanabe, Takashi Taniguchi, Sefaattin Tongay, Michael F Crommie, Feng Wang
The valley degree of freedom in two-dimensional (2D) crystals recently emerged as a novel information carrier in addition to spin and charge. The intrinsic valley lifetime in 2D transition metal dichalcogenides (TMD) is expected to be markedly long due to the unique spin-valley locking behavior, where the intervalley scattering of the electron simultaneously requires a large momentum transfer to the opposite valley and a flip of the electron spin. However, the experimentally observed valley lifetime in 2D TMDs has been limited to tens of nanoseconds thus far...
July 2017: Science Advances
https://www.readbyqxmd.com/read/28780854/structures-and-mechanisms-of-the-non-heme-fe-ii-and-2-oxoglutarate-dependent-ethylene-forming-enzyme-substrate-binding-creates-a-twist
#13
Salette Martinez, Matthias Fellner, Caitlyn Q Herr, Anastasia Ritchie, Jian Hu, Robert P Hausinger
The ethylene-forming enzyme (EFE) from Pseudomonas syringae pv. phaseolicola PK2 is a member of the mononuclear non-heme Fe(II)- and 2-oxoglutarate (2OG)-dependent oxygenase superfamily. EFE converts 2OG into ethylene plus three CO2 molecules while also catalyzing the C5 hydroxylation of L-arginine (L-Arg) driven by the oxidative decarboxylation of 2OG to form succinate and CO2. Here we report eleven X-ray crystal structures of EFE that provide insight into the mechanisms of these two reactions. Binding of 2OG in the absence of L-Arg resulted in predominantly monodentate metal coordination, distinct from the typical bidentate metal-binding species observed in other family members...
August 5, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28780125/effects-of-fullerene-on-lipid-bilayers-displaying-different-liquid-ordering-a-coarse-grained-molecular-dynamics-study
#14
Judit Sastre, Ilaria Mannelli, Ramon Reigada
BACKGROUND: The toxic effects and environmental impact of nanomaterials, and in particular of Fullerene particles, are matters of serious concern. It has been reported that fullerene molecules enter the cell membrane and occupy its hydrophobic region. Understanding the effects of carbon-based nanoparticles on biological membranes is therefore of critical importance to determine their exposure risks. METHODS: We report on a systematic coarse-grained molecular dynamics study of the interaction of fullerene molecules with simple model cell membranes...
August 2, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28777636/neural-decoder-for-topological-codes
#15
Giacomo Torlai, Roger G Melko
We present an algorithm for error correction in topological codes that exploits modern machine learning techniques. Our decoder is constructed from a stochastic neural network called a Boltzmann machine, of the type extensively used in deep learning. We provide a general prescription for the training of the network and a decoding strategy that is applicable to a wide variety of stabilizer codes with very little specialization. We demonstrate the neural decoder numerically on the well-known two-dimensional toric code with phase-flip errors...
July 21, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28777607/cat-codes-with-optimal-decoherence-suppression-for-a-lossy-bosonic-channel
#16
Linshu Li, Chang-Ling Zou, Victor V Albert, Sreraman Muralidharan, S M Girvin, Liang Jiang
We investigate cat codes that can correct multiple excitation losses and identify two types of logical errors: bit-flip errors due to excessive excitation loss and dephasing errors due to quantum backaction from the environment. We show that selected choices of logical subspace and coherent amplitude significantly reduce dephasing errors. The trade-off between the two major errors enables optimized performance of cat codes in terms of minimized decoherence. With high coupling efficiency, we show that one-way quantum repeaters with cat codes feature a boosted secure communication rate per mode when compared to conventional encoding schemes, showcasing the promising potential of quantum information processing with continuous variable quantum codes...
July 21, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28777594/sign-flip-in-the-casimir-force-for-interacting-fermion-systems
#17
Antonino Flachi, Muneto Nitta, Satoshi Takada, Ryosuke Yoshii
In this work we consider a fermionic chain of finite length ℓ. Fermions are allowed to interact and are forced to obey boundary conditions, thus altering the process of condensation. Our goal is to explore how this affects the quantum vacuum energy for this system. We approach this problem by using a self-consistent method and observe a nontrivial behavior in the Casimir force, displaying a switch from an attractive to a repulsive regime. This flip stems from the competition between the attractive contribution from the usual fermionic Casimir effect and a repulsive one coming from the condensate...
July 21, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28774679/ultra-high-field-tof-mra-a-method-to-visualize-small-cerebral-vessels-7t-tof-mra-sequence-parameters-on-different-mri-scanners-literature-review
#18
REVIEW
Cezary Grochowski, Grzegorz Staśkiewicz
INTRODUCTION: Time-of-flight (TOF) angiography is a technique allowing to visualize the blood flow in vessels. 7T ToF-MRA is able to visualize the whole Circle of Willis including small perforating branches without any known side effects as opposed to usually used DSA and CTA with high exposition to the radiation and high doses of contrast as far as CTA is concerned. AIM: The aim of this review is to describe ultra-high field ToF-MRA and present different protocol data depending on the scanner used in the study...
July 8, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/28772792/phosphor-free-ingan-white-light-emitting-diodes-using-flip-chip-technology
#19
Ying-Chang Li, Liann-Be Chang, Hou-Jen Chen, Chia-Yi Yen, Ke-Wei Pan, Bohr-Ran Huang, Wen-Yu Kuo, Lee Chow, Dan Zhou, Ewa Popko
Monolithic phosphor-free two-color gallium nitride (GaN)-based white light emitting diodes (LED) have the potential to replace current phosphor-based GaN white LEDs due to their low cost and long life cycle. Unfortunately, the growth of high indium content indium gallium nitride (InGaN)/GaN quantum dot and reported LED's color rendering index (CRI) are still problematic. Here, we use flip-chip technology to fabricate an upside down monolithic two-color phosphor-free LED with four grown layers of high indium quantum dots on top of the three grown layers of lower indium quantum wells separated by a GaN tunneling barrier layer...
April 20, 2017: Materials
https://www.readbyqxmd.com/read/28771474/a-flagellum-specific-chaperone-facilitates-assembly-of-the-core-type-iii-export-apparatus-of-the-bacterial-flagellum
#20
Florian D Fabiani, Thibaud T Renault, Britta Peters, Tobias Dietsche, Eric J C Gálvez, Alina Guse, Karen Freier, Emmanuelle Charpentier, Till Strowig, Mirita Franz-Wachtel, Boris Macek, Samuel Wagner, Michael Hensel, Marc Erhardt
Many bacteria move using a complex, self-assembling nanomachine, the bacterial flagellum. Biosynthesis of the flagellum depends on a flagellar-specific type III secretion system (T3SS), a protein export machine homologous to the export machinery of the virulence-associated injectisome. Six cytoplasmic (FliH/I/J/G/M/N) and seven integral-membrane proteins (FlhA/B FliF/O/P/Q/R) form the flagellar basal body and are involved in the transport of flagellar building blocks across the inner membrane in a proton motive force-dependent manner...
August 2017: PLoS Biology
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