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https://www.readbyqxmd.com/read/28097749/positive-contrast-from-cells-labeled-with-iron-oxide-nanoparticles-quantitation-of-imaging-data
#1
Sergey Magnitsky, Jinjin Zhang, Djaudat Idiyatullin, Geetha Mohan, Michael Garwood, Nancy E Lane, Sharmila Majumdar
PURPOSE: Conventional T2 -weighted MRI produces a hypointense signal from iron-labeled cells, which renders quantification unfeasible. We tested a SWeep Imaging with Fourier Transformation (SWIFT) MRI pulse sequence to generate a quantifiable hyperintense signal from iron-labeled cells. METHODS: Mesenchymal stem cells (MSCs) were labeled with different concentrations of iron oxide particles and examined for cell viability, proliferation, and differentiation. The SWIFT sequence was optimized to detect and quantify the amount of iron in the muscle tissue after injection of iron oxide solution and iron-labeled MSCs...
January 17, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28097733/optimized-amplitude-modulated-multiband-rf-pulse-design
#2
Samy Abo Seada, Anthony N Price, Joseph V Hajnal, Shaihan J Malik
PURPOSE: Multiband pulses are characterized by highly temporally modulated waveforms. Rapid phase or frequency modulation can be extremely demanding on the performance of radiofrequency (RF) pulse generation, which can lead to errors that can be avoided if pulses are restricted to amplitude modulation (AM) only. In this work, three existing multiband pulse design techniques are modified to produce AM waveforms. THEORY AND METHODS: Multiband refocusing pulses were designed using phase optimization, time shifting, and root flipping...
January 17, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28096733/diagnosis-of-nerve-root-compromise-of-the-lumbar-spine-evaluation-of-the-performance-of-three-dimensional-isotropic-t2-weighted-turbo-spin-echo-space-sequence-at-3t
#3
Jinkyeong Sung, Won-Hee Jee, Joon-Yong Jung, Jinhee Jang, Jin-Sung Kim, Young-Hoon Kim, Kee-Yong Ha
OBJECTIVE: To explore the performance of three-dimensional (3D) isotropic T2-weighted turbo spin-echo (TSE) sampling perfection with application optimized contrasts using different flip angle evolution (SPACE) sequence on a 3T system, for the evaluation of nerve root compromise by disc herniation or stenosis from central to extraforaminal location of the lumbar spine, when used alone or in combination with conventional two-dimensional (2D) TSE sequence. MATERIALS AND METHODS: Thirty-seven patients who had undergone 3T spine MRI including 2D and 3D sequences, and had subsequent spine surgery for nerve root compromise at a total of 39 nerve levels, were analyzed...
January 2017: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/28095878/black-blood-thrombus-imaging-bti-a-contrast-free-cardiovascular-magnetic-resonance-approach-for-the-diagnosis-of-non-acute-deep-vein-thrombosis
#4
Guoxi Xie, Hanwei Chen, Xueping He, Jianke Liang, Wei Deng, Zhuonan He, Yufeng Ye, Qi Yang, Xiaoming Bi, Xin Liu, Debiao Li, Zhaoyang Fan
BACKGROUND: Deep vein thrombosis (DVT) is a common but elusive illness that can result in long-term disability or death. Accurate detection of thrombosis and assessment of its size and distribution are critical for treatment decision-making. In the present study, we sought to develop and evaluate a cardiovascular magnetic resonance (CMR) black-blood thrombus imaging (BTI) technique, based on delay alternating with nutation for tailored excitation black-blood preparation and variable flip angle turbo-spin-echo readout, for the diagnosis of non-acute DVT...
January 18, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28094889/selective-electrochemical-bleaching-of-the-outer-leaflet-of-fluorescently-labelled-giant-liposomes
#5
Olivier Buriez, Ana Isabel Perez Jimenez, Lylian Challier, Eric Aït-Yahiatène, Jerome Delacotte, Eric Labbe
Electrochemistry and confocal fluorescence microscopy were successfully combined to selectively bleach and monitor the fluorescence of NBD-labelled phospholipids of giant liposomes. Three types of giant unilamellar vesicles have been investigated, the fluorescent phospholipids being localized either mainly on their outer-, inner-, or both inner/outer leaflets. We established that only the fluorescent lipids incorporated in the outer leaflet of the vesicles underwent electrochemical bleaching upon reduction...
January 17, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28092835/effects-of-the-central-potassium-ions-on-the-g-quadruplex-and-stabilizer-binding
#6
Zhiguo Wang, Jun-Ping Liu
Human telomeres undertake the structure of intra-molecular parallel G-quadruplex in the presence of K(+) in eukaryotic cell. Stabilization of the telomere G-quadruplex represents a potential strategy to prevent telomere lengthening by telomerase in cancer therapy. Current work demonstrates that the binding of central K(+) with the parallel G-quadruplex is a coordinated water directed step-wise process. The K(+) above the top G-tetrad is prone to leak into environment and the 5'-adenine quickly flips over the top G-tetrad, leading to the bottom gate of G-tetrads as the only viable pathway of K(+) binding...
January 6, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28092785/integrated-ssfp-for-functional-brain-mapping-at-7t-with-reduced-susceptibility-artifact
#7
Kaibao Sun, Rong Xue, Peng Zhang, Zhentao Zuo, Zhongwei Chen, Bo Wang, Thomas Martin, Yi Wang, Lin Chen, Sheng He, Danny J J Wang
Balanced steady-state free precession (bSSFP) offers an alternative and potentially important tool to the standard gradient-echo echo-planar imaging (GE-EPI) for functional MRI (fMRI). Both passband and transition band based bSSFP have been proposed for fMRI. The applications of these methods, however, are limited by banding artifacts due to the sensitivity of bSSFP signal to off-resonance effects. In this article, a unique case of the SSFP-FID sequence, termed integrated-SSFP or iSSFP, was proposed to overcome the obstacle by compressing the SSFP profile into the width of a single voxel...
December 30, 2016: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28092744/quercetin-induces-apoptosis-and-autophagy-in-primary-effusion-lymphoma-cells-by-inhibiting-pi3k-akt-mtor-and-stat3-signaling-pathways
#8
Marisa Granato, Celeste Rizzello, Maria Saveria Gilardini Montani, Laura Cuomo, Marina Vitillo, Roberta Santarelli, Roberta Gonnella, Gabriella D'Orazi, Alberto Faggioni, Mara Cirone
Quercetin, a bioflavonoid contained in several vegetables daily consumed, has been studied for long time for its antiinflammatory and anticancer properties. Quercetin interacts with multiple cancer-related pathways such as PI3K/AKT, Wnt/β-catenin and STAT3. These pathways are hyperactivated in primary effusion lymphoma (PEL), an aggressive B cell lymphoma whose pathogenesis is strictly linked to the oncogenic virus Kaposis' Sarcoma-associated Herpesvirus (KSHV). In this study, we found that quercetin inhibited PI3K/AKT/mTOR and STAT3 pathways in PEL cells, and as a consequence, it down-regulated the expression of the prosurvival cellular proteins such as c-FLIP, cyclin D1 and cMyc...
January 5, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28088430/flipping-the-classroom-case-based-learning-accountability-assessment-and-feedback-leads-to-a-favorable-change-in-culture
#9
Nahush A Mokadam, Todd F Dardas, Joshua L Hermsen, Jay D Pal, Michael S Mulligan, L Myria Jacobs, Douglas E Wood, Edward D Verrier
OBJECTIVE: The 88-week Thoracic Surgery Curriculum is challenging to implement because of the large content in a traditional lecture format. This study investigates flipping the classroom by using a case-based format designed to stimulate resident preparation and engagement. METHODS: The didactic conference format was altered. Curricular reading assignments, case review, and conference participation prepared residents for novel formative assessment quizzes. Ten residents participated, and faculty served as controls...
December 19, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28079371/a-binding-pose-flip-explained-via-enthalpic-and-entropic-contributions
#10
Michael Schauperl, Paul Czodrowski, Julian E Fuchs, Roland G Huber, Birgit J Waldner, Maren Podewitz, Christian Kramer, Klaus R Liedl
The anomalous binding modes of five highly similar fragments of TIE2 inhibitors, showing three distinct binding poses are investigated. We report a quantitative rationalization for the changes in binding pose based on molecular dynamics simulations. We investigated five fragments in complex with the transforming growth factor β receptor type 1 kinase domain. Analyses of these simulations using Grid Inhomogeneous Solvation Theory (GIST), pKA calculations, and a tool to investigate enthalpic differences upon binding unraveled the various thermodynamic contributions to the different binding modes...
January 12, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28079359/pristine-graphene-electrode-in-hydrogen-evolution-reaction
#11
Aozhen Xie, Ningning Xuan, Kun Ba, Zhengzong Sun
Graphene, the sp2 carbonaceous two dimensional (2D) material, is gaining more attentions in recent electrochemical studies. However, this atomic thick electrode usually suffers with surface contamination and poor electrochemical endurance. To overcome the drawbacks, we developed a PMMA-assisted, flipped transfer method to fabricate the graphene electrode with pristine surface and prolonged lifetime in hydrogen evolution reaction (HER). The HER performances of the single-layer graphene (SLG) were evaluated on various insulating and conductive substrates, including SiO2, polymers, SLG, highly oriented pyrolytic graphite (HOPG), and copper...
January 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28075327/orbital-driven-impurity-spin-effect-on-the-magnetic-order-of-quasi-three-dimensional-cupric-oxide
#12
B Ganga, P Santhosh, B R K Nanda
Density functional calculations are performed to study the magnetic order of the severely distorted square planar cupric oxide (CuO) and local spin disorder in it in the presence of the transition metal impurities M (= Cr, Mn, Fe, Co and Ni). The distortion in the crystal structure, arisen to reduce the band energy by minimizing the covalent interaction, creates two crisscrossing zigzag spin-1/2 chains. From the spin dimer analysis we find that while the spin chain along [101 ��] has strong Heisenberg type antiferromagnetic coupling (J ~ 127 meV), along [101] it exhibits weak, but robust, ferromagnetic coupling (J ~ 9 meV) mediated by reminiscent p-d covalent interactions...
January 11, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28074609/rapid-chemical-shift-encoding-with-single-acquisition-single-slab-3d-grase
#13
Hahnsung Kim, Dong-Hyun Kim, Chul-Ho Sohn, Jaeseok Park
PURPOSE: To investigate the feasibility of chemical shift encoded, single-slab 3D GRASE for rapid fat-water separation within a single acquisition. METHODS: The proposed method incorporates signal-to-noise-ratio-optimal chemical shift encoding into single-slab 3D GRASE with variable flip angles. Chemical shift induced phase information was encoded in succession to different positions in k-space by inserting phase encoding blips between adjacent lobes of the oscillating readout gradients...
January 11, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28074576/decisions-and-authority
#14
Gregory E Kaebnick
This issue of the Hastings Center Report (January-February 2017) features three articles exploring aspects of decision-making for others. In the first two, the focus is on the limits of surrogate decision-makers' authority when the surrogates' judgments about a patient's treatment conflict with the physicians'. If a physician decides that a patient will not benefit from CPR, for example, but the patient's surrogate insists on it, is the physician obliged to proceed with the procedure? Or can the physician, pointing to a duty to provide good care to the patient and not to cause the patient to suffer, get a do-not-resuscitate order for the patient-even in the face of the surrogate's objections? These are the questions that animate the first article, in which a group of authors report on a policy implemented at Massachusetts General Hospital to help doctors who face this dilemma...
January 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28067276/flip-flop-of-day-night-and-summer-winter-surface-urban-heat-island-intensity-in-india
#15
Hiteshri Shastri, Beas Barik, Subimal Ghosh, Chandra Venkataraman, Pankaj Sadavarte
The difference in land surface temperature (LST) between an urban region and its nearby non-urban region, known as surface urban heat island intensity (SUHII), is usually positive as reported in earlier studies. India has experienced unprecedented urbanization over recent decades with an urban population of 380 million. Here, we present the first study of the diurnal and seasonal characteristics of SUHII in India. We found negative SUHII over a majority of urban areas during daytime in pre-monsoon summer (MAM), contrary to the expected impacts of urbanization...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28063440/recovering-dynamic-correlation-in-spin-flip-configuration-interaction-through-a-difference-dedicated-approach
#16
Alan D Chien, Paul M Zimmerman
This article introduces the restricted-active-space n-spin flip configuration interaction models, RAS(S)-SF and RAS(S,2h,2p)-SF, which provide highly correlated, yet low cost approaches for treating polyradical systems. These levels of theory add electronic degrees of freedom beyond those of previous spin flip approaches in order to achieve accurate ground and excited state energetics. The effects of additional dynamic correlation were investigated by comparing these two techniques to the prior RAS(h,p)-SF method on a variety of test systems, including multiple electronic states of methylene, tetramethyleneethane, three binuclear transition metal complexes, and a tetracene dimer...
January 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28061002/closed-form-expressions-for-flip-angle-variation-that-maximize-total-signal-in-t1-weighted-rapid-gradient-echo-mri
#17
Matthias Drobnitzky, Uwe Klose
PURPOSE: Magnetization-prepared rapid gradient-echo (MPRAGE) sequences are commonly employed for T1-weighted structural brain imaging. Following a contrast preparation radiofrequency (RF) pulse the data acquisition proceeds under non-equilibrium conditions of the relaxing longitudinal magnetization. Variation of the flip angle can be used to maximize total available signal. Simulated annealing or greedy algorithms have so far been published to numerically solve this problem, with signal to noise ratios optimized for clinical imaging scenarios by adhering to a predefined shape of the signal evolution...
January 6, 2017: Medical Physics
https://www.readbyqxmd.com/read/28059259/ge-sub-0-975-sub-sn-sub-0-025-sub-320%C3%A2-%C3%A2-%C3%A3-%C3%A2-%C3%A2-256-imager-chip-for-1-6-1-9%C3%A2-%C3%A2-%C3%AE-m-infrared-vision
#18
Chiao Chang, Hui Li, Chien-Te Ku, Shih-Guo Yang, Hung Hsiang Cheng, Joshua Hendrickson, Richard A Soref, Greg Sun
We report the experimental fabrication and testing of a GeSn-based 320×256 image sensor focal plane array operating at -15°C in the 1.6-1.9 μm spectral range. For image readout, the 2D pixel array of Ge/GeSn/Ge p-i-n heterophotodiodes was flip-chip bonded to a customized silicon CMOS readout integrated circuit. The resulting camera chip was operated using back-side illumination. Successful imaging of a tungsten-filament light bulb was attained with observation of gray-scale "hot spot" infrared features not seen using a visible-light camera...
December 20, 2016: Applied Optics
https://www.readbyqxmd.com/read/28058630/il-33-acts-as-a-foe-to-mia-paca-2-pancreatic-cancer
#19
Yujiang Fang, Lei Zhao, Huaping Xiao, Kathryn M Cook, Qian Bai, Elizabeth J Herrick, Xuhui Chen, Chenglu Qin, Ziwen Zhu, Mark R Wakefield, Michael B Nicholl
IL-33 is a member of the IL-1 family of cytokines, and no study has been performed to address its direct anti-tumor effect. This study is designed to investigate whether IL-33 has any direct effect on pancreatic cancer. Clonogenic survival assay, immunohistochemistry, TUNEL staining, proliferation, caspase-3 activity kits and RT-PCR were used to evaluate the effects of IL-33 on cell survival, proliferation and apoptosis of a pancreatic cancer cell line, MIA PaCa-2. We found that the percentage of colonies of MIA PaCa-2 cells, PCNA+ cells and the OD value of cancer cells were all decreased in the presence of IL-33...
February 2017: Medical Oncology
https://www.readbyqxmd.com/read/28056583/neglected-traumatic-anterior-dislocation-of-the-hip-open-reduction-using-the-bernese-trochanter-flip-approach-a-case-report
#20
Sven Young, Leonard Banza
No abstract text is available yet for this article.
January 6, 2017: Acta Orthopaedica
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