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https://www.readbyqxmd.com/read/27932572/a-mechanism-for-acetylcholine-receptor-gating-based-on-structure-coupling-phi-and-flip
#1
Shaweta Gupta, Srirupa Chakraborty, Ridhima Vij, Anthony Auerbach
Nicotinic acetylcholine receptors are allosteric proteins that generate membrane currents by isomerizing ("gating") between resting and active conformations under the influence of neurotransmitters. Here, to explore the mechanisms that link the transmitter-binding sites (TBSs) with the distant gate, we use mutant cycle analyses to measure coupling between residue pairs, phi value analyses to sequence domain rearrangements, and current simulations to reproduce a microsecond shut component ("flip") apparent in single-channel recordings...
December 8, 2016: Journal of General Physiology
https://www.readbyqxmd.com/read/27932490/c-terminus-of-the-p4-atpase-atp8a2-functions-in-protein-folding-and-regulation-of-phospholipid-flippase-activity
#2
Madhavan Chalat, Kody Moleschi, Robert S Molday
ATP8A2 is a P4-ATPase that flips phosphatidylserine and phosphatidylethanolamine across cell membranes. This generates membrane phospholipid asymmetry, a property important in many cellular processes including vesicle trafficking. ATP8A2 deficiency causes severe neurodegenerative diseases. We have investigated the role of the C-terminus of ATP8A2 in its expression, subcellular localization, interaction with its subunit CDC50A, and function as a phosphatidylserine flippase. C-terminal deletion mutants exhibited a reduced tendency to solubilize in mild detergent and exit the endoplasmic reticulum...
December 8, 2016: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/27929474/a-simple-one-step-dissection-protocol-for-whole-mount-preparation-of-adult-drosophila-brains
#3
Antonio J Tito, Shebna Cheema, Mian Jiang, Sheng Zhang
There is an increasing interest in using Drosophila to model human brain degenerative diseases, map neuronal circuitries in adult brains, and study the molecular and cellular basis of higher brain functions. A whole-mount preparation of adult brains with well-preserved morphology is critical for such whole brain-based studies, but can be technically challenging and time-consuming. This protocol describes an easy-to-learn, one-step dissection approach of an adult fly head in less than 10 s, while keeping the intact brain attached to the rest of the body to facilitate subsequent processing steps...
December 1, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27927016/inhibition-of-cathepsin-s-induces-mitochondrial-ros-that-sensitizes-trail-mediated-apoptosis-through-p53-mediated-down-regulation-of-bcl-2-and-c-flip
#4
Bo Ram Seo, Kyoung-Jin Min, Seon Min Woo, Misun Choe, Kyeong Sook Choi, Young-Kyung Lee, Gyesoon Yoon, Taeg Kyu Kwon
AIMS: Cathepsin S is highly expressed in various cancer cells, and it has pro-tumoral effects, including promotion of migration, invasion and neovascularization. In this study, we show that inhibition of cathepsin S could sensitize cancer cells to TRAIL-mediated apoptosis. RESULTS: An inhibitor of cathepsin S (Z-FL-COCHO; ZFL) markedly induced apoptosis in human renal cancer cells treated with TRAIL. In contrast, combined treatment with ZFL and TRAIL had no effect on normal cells...
December 7, 2016: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/27924865/quantum-error-correction-protects-quantum-search-algorithms-against-decoherence
#5
Panagiotis Botsinis, Zunaira Babar, Dimitrios Alanis, Daryus Chandra, Hung Nguyen, Soon Xin Ng, Lajos Hanzo
When quantum computing becomes a wide-spread commercial reality, Quantum Search Algorithms (QSA) and especially Grover's QSA will inevitably be one of their main applications, constituting their cornerstone. Most of the literature assumes that the quantum circuits are free from decoherence. Practically, decoherence will remain unavoidable as is the Gaussian noise of classic circuits imposed by the Brownian motion of electrons, hence it may have to be mitigated. In this contribution, we investigate the effect of quantum noise on the performance of QSAs, in terms of their success probability as a function of the database size to be searched, when decoherence is modelled by depolarizing channels' deleterious effects imposed on the quantum gates...
December 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27923771/off-axis-astigmatism-in-the-isolated-chicken-crystalline-lens
#6
Felix Maier, Siegfried Wahl, Frank Schaeffel
The chicken eye was previously found to have little off-axis astigmatism which is not explained by its special corneal shape but rather by the optical properties of the crystalline lens. To learn more about lens design, we studied off-axis astigmatism in the chicken lens in situ and compared it to a glass lens of similar power but with homogenous refractive index. After euthanasia, enucleated eye balls were cut in the equatorial plane right behind the scleral ossicles. The anterior segment was placed in a water-filled chamber...
December 2016: Vision Research
https://www.readbyqxmd.com/read/27923658/temporal-regulation-of-gap-junctional-communication-between-tenocytes-subjected-to-static-tensile-strain-with-physiological-and-non-physiological-amplitudes
#7
Eijiro Maeda, Haicheng Pian, Toshiro Ohashi
The present study has been performed on temporal changes in gap junctional intercellular communication (GJIC) between tenocytes under static tensile strain with the magnitude of 0% (no strain), 4% (physiological magnitude) or 8% (overloading magnitude) during a 24-h culture period. Tenocytes were isolated from rabbit Achilles tendon and seeded on a stretchable microgroove substrate. GJIC was evaluated as intercellular diffusion coefficient of calcein (DGJ) using fluorescence loss in photobleaching (FLIP) protocol accompanied with a mathematical model of molecular diffusion both within the cell and between the cells...
December 3, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27921994/the-structure-of-sv40-large-t-hexameric-helicase-in-complex-with-at-rich-origin-dna
#8
Dahai Gai, Damian Wang, Shu-Xing Li, Xiaojiang S Chen
DNA replication is a fundamental biological process. The initial step in eukaryotic DNA replication is the assembly of the pre-initiation complex, including the formation of two head-to-head hexameric helicases around the replication origin. How these hexameric helicases interact with their origin dsDNA remains unknown. Here, we report the co-crystal structure of the SV40 Large-T Antigen (LT) hexameric helicase bound to its origin dsDNA. The structure shows that the six subunits form a near-planar ring that interacts with the origin, so that each subunit makes unique contacts with the DNA...
December 6, 2016: ELife
https://www.readbyqxmd.com/read/27918896/the-physical-mechanism-of-inhomogeneous-magnetization-transfer-mri
#9
Alan P Manning, Kimberley L Chang, Alex L MacKay, Carl A Michal
Inhomogeneous MT (ihMT) is a new magnetic resonance imaging technique that shows promise for myelin selectivity. Materials with a high proportion of lipids, such as white matter tissue, show a reduced intensity in magnetic resonance images acquired with selective prepulses at positive and negative offsets simultaneously compared to images with a single positive or negative offset prepulse of the same power. This effect was initially explained on the basis of hole-burning in inhomogeneously broadened lines of the lipid proton spin system...
November 24, 2016: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/27918836/evolvix-best-names-for-semantic-reproducibility-across-code2brain-interfaces
#10
Laurence Loewe, Katherine S Scheuer, Seth A Keel, Vaibhav Vyas, Ben Liblit, Bret Hanlon, Michael C Ferris, John Yin, Inês Dutra, Anthony Pietsch, Christine G Javid, Cecilia L Moog, Jocelyn Meyer, Jerdon Dresel, Brian McLoone, Sonya Loberger, Arezoo Movaghar, Morgaine Gilchrist-Scott, Yazeed Sabri, Dave Sescleifer, Ivan Pereda-Zorrilla, Andrew Zietlow, Rodrigo Smith, Samantha Pietenpol, Jacob Goldfinger, Sarah L Atzen, Erika Freiberg, Noah P Waters, Claire Nusbaum, Erik Nolan, Alyssa Hotz, Richard M Kliman, Ayalew Mentewab, Nathan Fregien, Martha Loewe
Names in programming are vital for understanding the meaning of code and big data. We define code2brain (C2B) interfaces as maps in compilers and brains between meaning and naming syntax, which help to understand executable code. While working toward an Evolvix syntax for general-purpose programming that makes accurate modeling easy for biologists, we observed how names affect C2B quality. To protect learning and coding investments, C2B interfaces require long-term backward compatibility and semantic reproducibility (accurate reproduction of computational meaning from coder-brains to reader-brains by code alone)...
December 5, 2016: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/27918116/multiferroic-nanopatterned-hybrid-material-with-room-temperature-magnetic-switching-of-the-electric-polarization
#11
Ronggang Cai, Vlad-Andrei Antohe, Zhijun Hu, Bernard Nysten, Luc Piraux, Alain M Jonas
A nanopatterned hybrid layer is designed, wherein the electric polarization can be flipped at room temperature by a magnetic field aided by an electrical field. This is achieved by embedding ferromagnetic nanopillars in a continuous organic ferroelectric layer, and amplifying the magnetostriction-generated stress gradients by scaling down the supracrystalline cell of the material.
December 5, 2016: Advanced Materials
https://www.readbyqxmd.com/read/27917529/accuracy-precision-and-reproducibility-of-myocardial-t1-mapping-a-comparison-of-four-t1-estimation-algorithms-for-modified-look-locker-inversion-recovery-molli
#12
Jiaxin Shao, Dapeng Liu, Kyunghyun Sung, Kim-Lien Nguyen, Peng Hu
PURPOSE: To compare the accuracy and precision of four different T1 estimation algorithms for modified Look-Locker inversion recovery (MOLLI). METHODS: Four T1 estimation algorithms, including the original fit, inversion group (IG) fit, instantaneous signal loss simulation (InSiL), and Bloch equation simulation with slice profile correction (BLESSPC) were studied. T1 estimation accuracy, precision, reproducibility, and sensitivity to heart rate (HR), flip angle (FA), and acquisition scheme (AcS) variations were compared in simulation, phantom, and volunteer studies...
December 4, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27914357/moving-toward-heutagogical-learning-illuminating-undergraduate-nursing-students-experiences-in-a-flipped-classroom
#13
Rebecca D Green, Maura C Schlairet
BACKGROUND: Nurse educators rely on the tenets of educational theory and evidence-based education to promote the most effective curriculum and facilitate the best outcomes. The flipped classroom model, in which students assume personal responsibility for knowledge acquisition in a highly engaging and interactive environment, supports self-directed learning and the unique needs of clinical education. OBJECTIVE: To understand how students perceived their experiences in the flipped classroom and how students' learning dispositions were affected by the flipped classroom experience...
November 25, 2016: Nurse Education Today
https://www.readbyqxmd.com/read/27911937/an-investigation-of-the-outcomes-of-pgy-students-cognition-of-and-persistent-behavior-in-learning-through-the-intervention-of-the-flipped-classroom-in-taiwan
#14
Sheng-Der Hsu, Cheng-Jueng Chen, Wei-Kuo Chang, Yih-Jin Hu
The Postgraduate Year (PGY) Program allows doctors-in-training to learn about the diagnosis, treatment and nursing of various common, general diseases. These items form the core curriculum and are mostly learned through caring for patients and clinical teaching. Doctors-in-training are evaluated for their knowledge through written tests or assignments, based on which the effectiveness of their training is also assessed; however, this generally produces a negative learning attitude among them. So we introduced the flipped classroom into PGY training program to change PGY students' learning behavior...
2016: PloS One
https://www.readbyqxmd.com/read/27910618/faraday-cup-type-lost-fast-ion-detector-on-heliotron-j
#15
S Yamamoto, K Ogawa, M Isobe, D S Darrow, S Kobayashi, K Nagasaki, H Okada, T Minami, S Kado, S Ohshima, G M Weir, Y Nakamura, S Konoshima, N Kemmochi, Y Ohtani, T Mizuuchi
A Faraday-cup type lost-fast ion probe (FLIP) has been designed and installed in Heliotron J for the purpose of the studies of interaction between fast ions and MHD instabilities. The FLIP can measure the co-going fast ions whose energy is in the range of 1.7-42.5 keV (proton) and pitch angle of 90(∘)-140(∘), especially for fast ions having the injection energy of neutral beam injection (NBI). The FLIP successfully measured the re-entering passing ions and trapped lost-fast ions caused by fast-ion-driven energetic particle modes in NBI heated plasmas...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27909018/does-the-room-matter-active-learning-in-traditional-and-enhanced-lecture-spaces
#16
Jon R Stoltzfus, Julie Libarkin
SCALE-UP-type classrooms, originating with the Student-Centered Active Learning Environment with Upside-down Pedagogies project, are designed to facilitate active learning by maximizing opportunities for interactions between students and embedding technology in the classroom. Positive impacts when active learning replaces lecture are well documented, both in traditional lecture halls and SCALE-UP-type classrooms. However, few studies have carefully analyzed student outcomes when comparable active learning-based instruction takes place in a traditional lecture hall and a SCALE-UP-type classroom...
2016: CBE Life Sciences Education
https://www.readbyqxmd.com/read/27908122/static-polarizabilities-for-excited-states-within-the-spin-conserving-and-spin-flipping-equation-of-motion-coupled-cluster-singles-and-doubles-formalism-theory-implementation-and-benchmarks
#17
Kaushik D Nanda, Anna I Krylov
We present the theory and implementation for calculating static polarizabilities within the equation-of-motion coupled-cluster singles and doubles (EOM-CCSD) framework for electronically excited states and its spin-flip variant. We evaluate the second derivatives of the EOM-CCSD Lagrangian with respect to electric-field perturbations. The relaxation of reference molecular orbitals is not included. In our approach, the wave function amplitudes satisfy the 2n + 1 rule and the amplitude-response Lagrange multipliers satisfy the 2n + 2 rule...
November 28, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27907980/flipped-clinical-training-a-structured-training-method-for-undergraduates-in-complete-denture-prosthesis
#18
Anbarasi K, Kasim Mohamed K, Phagalvarthy Vijayaraghavan, Deivanayagam Kandaswamy
PURPOSE: To design and implement flipped clinical training for undergraduate dental students in removable complete denture treatment and predict its effectiveness by comparing the assessment results of students trained by flipped and traditional methods. METHODS: Flipped training was designed by shifting the learning from clinics to learning center (phase I) and by preserving the practice in clinics (phase II). In phase I, student-faculty interactive session was arranged to recap prior knowledge...
December 2016: Korean Journal of Medical Education
https://www.readbyqxmd.com/read/27906318/papr-analysis-for-ofdm-visible-light-communication
#19
Jiaheng Wang, Yang Xu, Xintong Ling, Rong Zhang, Zhi Ding, Chunming Zhao
Orthogonal frequency-division multiplexing (OFDM) is a practical technology in visible light communication (VLC) for high-speed transmissions. However, one of its operational limitations is the peak-to-average power ratio (PAPR) of the transmitted signal. In this paper, we analyze the PAPR distributions of four VLC OFDM schemes, namely DC-biased optical OFDM (DCO-OFDM), asymmetrically clipped optical OFDM (ACO-OFDM), pulse amplitude modulated discrete multitone (PAM-DMT), and Flip-OFDM. Both lower and upper clippings are considered...
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27905602/achieving-enhanced-ionic-mobility-in-nanoporous-silica-by-controlled-surface-interactions
#20
Mounesha Nagendrachar Garaga, Luis Aguilera, Negin Yaghini, Aleksandar Matic, Michael Persson, Anna Martinelli
We report a strategy to enhance the ionic mobility in an emerging class of gels, based on robust nanoporous silica micro-particles, by chemical functionalization of the silica surface. Two very different ionic liquids are used to fill the nano-pores of silica at varying pore filling factors, namely one aprotic imidazolium based (1-methyl-3-hexylimidazolium bis(trifluoromethanesulfonyl)imide, C6C1ImTFSI), and one protic ammonium based (diethylmethylammonium methanesulfonate, DEMAOMs) ionic liquid. Both these ionic liquids display higher ionic mobility when confined in functionalized silica as compared to untreated silica nano-pores, an improvement that is more pronounced at low pore filling factors (i...
December 1, 2016: Physical Chemistry Chemical Physics: PCCP
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