Matthias Greutmann, Daniel Tobler, Reto Engel, Dik Heg, Christian Mueller, André Frenk, Harald Gabriel, Tobias Rutz, Ronny R Buechel, Matthias Willhelm, Lukas Trachsel, Michael Freese, Francisco Javier Ruperti-Repilado, Emanuela Valsangiacomo Buechel, Dietrich Beitzke, Philip Haaf, Kerstin Wustmann, Fabienne Schwitz, Mathias Possner, Juerg Schwitter, Judith Bouchardy, Markus Schwerzmann
BACKGROUND AND AIMS: In adults with congenital heart disease and systemic right ventricles, progressive right ventricular systolic dysfunction is common and is associated with adverse outcomes. Our aim was to assess the impact of the phosphodiesterase-5-inhibitor tadalafil on right ventricular systolic function. METHODS AND RESULTS: This was a double-blind, randomized, placebo-controlled, multi-center superiority trial (NCT03049540) involving 100 adults with systemic right ventricles (33 women, mean age: 40...
June 1, 2023: European Journal of Heart Failure