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Exercise adult congenital heart disease

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https://www.readbyqxmd.com/read/28323585/feasibility-of-hypoxic-challenge-testing-in-children-and-adolescents-with-congenital-heart-and-lung-disease
#1
Mandy E Spoorenberg, Erik H J Hulzebos, Tim Takken
BACKGROUND: This is a cross-sectional observational study to investigate the safety and feasibility of integrating changing body positions and physical activity in a hypoxic challenge test (HCT). The secondary objective was to compare oxygen saturation (Spo2) in two different locations (forehead and finger). METHODS: Included were 12 pediatric to young adult patients with congenital heart (N = 7) or lung disease (N = 5). An HCT was performed using breathing room air (21% oxygen) while sitting and breathing a normobaric hypoxic gas mixture (15% oxygen) through a facemask while seated, lying supine, standing, walking 3 km/h, and walking 5 km/h in a nonrandomized order...
December 1, 2016: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28318658/sudden-death-in-athletes
#2
Domenico Corrado, Alessandro Zorzi
Competitive sports activity is associated with an increased risk of sudden cardiovascular death (SCD) in adolescents and young adults with clinically silent cardiovascular disorders. While in middle-aged/senior athletes atherosclerotic coronary artery disease accounts for the vast majority of SCDs, in young athletes the spectrum of substrates is wider and includes inherited (cardiomyopathies) and congenital (anomalous origin of coronary arteries) structural heart diseases. Inherited ion channel diseases have been implicated in SCDs occurring with an apparently normal heart at autopsy...
March 10, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28274955/physical-activity-in-adults-with-congenital-heart-disease-and-associations-with-functional-outcomes
#3
Jan Müller, Tamara Amberger, Anika Berg, Daniel Goeder, Julia Remmele, Renate Oberhoffer, Peter Ewert, Alfred Hager
OBJECTIVE: Improved survival has yielded to growing importance of functional outcome measures in patients with congenital heart disease (CHD). This study applied the International Physical Activity Questionnaire (IPAQ) to assess self-reported physical activity (PA) in patients with CHD and their association with exercise capacity and health-related quality of life (HrQoL). PATIENTS AND METHODS: Prior to cardiopulmonary exercise testing (CPET), 786 consecutive patients (335 female, 31...
March 8, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28237971/body-mass-index-in-adult-congenital-heart-disease
#4
Margarita Brida, Konstantinos Dimopoulos, Alexander Kempny, Emmanouil Liodakis, Rafael Alonso-Gonzalez, Lorna Swan, Anselm Uebing, Helmut Baumgartner, Michael A Gatzoulis, Gerhard-Paul Diller
OBJECTIVE: Abnormal body mass index (BMI) is associated with higher mortality in various cardiovascular cohorts. The prognostic implications of BMI in adults with congenital heart disease (ACHD) are unknown. We aim to assess the distribution of BMI and its association with symptoms and survival in the ACHD population. METHODS: We included 3069 ACHD patients (median age 32.6 years) under follow-up at our institution between 2001 and 2015. Patients were classified based on BMI as underweight (<18...
February 25, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28126509/-cardiac-rehabilitation-for-children-and-adults-with-congenital-heart-disease
#5
Pascal Amedro, Arthur Gavotto, Charlène Bredy, Sophie Guillaumont
Advances in heart surgery over the past 30 years have significantly improved the prognosis of congenital heart diseases (CHD). Therefore, the epidemiology of CHD has changed dramatically with a shift of mortality from pediatrics to adulthood and an increased prevalence of complex CHD. Today, caregivers and patients focus their interests to new perspectives: improving the quality of life, practicing sports, improving psychosocial care. Cardiac rehabilitation is completely integrated in these new therapeutic strategies...
January 23, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/28125022/pediatric-exercise-testing-value-and-implications-of-peak-oxygen-uptake
#6
REVIEW
Paolo T Pianosi, Robert I Liem, Robert G McMurray, Frank J Cerny, Bareket Falk, Han C G Kemper
Peak oxygen uptake (peak V ˙ O 2 ) measured by clinical exercise testing is the benchmark for aerobic fitness. Aerobic fitness, estimated from maximal treadmill exercise, is a predictor of mortality in adults. Peak V ˙ O 2 was shown to predict longevity in patients aged 7-35 years with cystic fibrosis over 25 years ago. A surge of exercise studies in young adults with congenital heart disease over the past decade has revealed significant prognostic information. Three years ago, the first clinical trial in children with pulmonary arterial hypertension used peak V ˙ O 2 as an endpoint that likewise delivered clinically relevant data...
January 24, 2017: Children
https://www.readbyqxmd.com/read/27931725/body-weights-in-adults-with-congenital-heart-disease-and-the-obesity-frequency
#7
Joseph B Lerman, Ira A Parness, Rajesh U Shenoy
Obesity may associate with greater cardiovascular risk in adults with congenital heart disease (ACHD) than in the general population. As ACHD often have exercise limitations, they may be uniquely predisposed to obesity. Nevertheless, obesity prevalence in ACHD, compared with the general population, has not been quantified in a large US cohort. Hence, we sought to determine the prevalence of obesity (30 ≤ body mass index <40) and morbid obesity (body mass index ≥40), in a large cohort of ACHD, compared with matched controls...
November 16, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27620913/nt-probnp-and-exercise-capacity-in-adult-patients-with-congenital-heart-disease-and-a%C3%A2-prosthetic-valve-a%C3%A2-multicentre-prostava-study
#8
R C Schoonbeek, P G Pieper, Y J van Slooten, H G Freling, G T Sieswerda, A P J van Dijk, M R M Jongbloed, M C Post, B J Bouma, R M F Berger, T Ebels, J P van Melle
OBJECTIVES: N-terminal B‑type natriuretic peptide (NT-proBNP) is an important biomarker for the detection of heart failure. Adults with congenital heart disease (ACHD) and a prosthetic heart valve are at risk for heart failure. This study aimed to determine the value of NT-proBNP in ACHD patients with a prosthetic valve and investigate its relationship with cardiac function and exercise capacity. METHODS: In this multi-centre cross-sectional observational study, data regarding medical history, echocardiography, exercise testing (VO2peak) and laboratory blood evaluation (including NT-proBNP) were collected in ACHD patients with a single prosthetic valve (either homografts, heterografts or mechanical valves)...
November 2016: Netherlands Heart Journal
https://www.readbyqxmd.com/read/27555292/transgenerational-cardiology-one-way-to-a-baby-s-heart-is-through-the-mother
#9
Patrick Y Jay, Ehiole Akhirome, Rachel A Magnan, M Rebecca Zhang, Lillian Kang, Yidan Qin, Nelson Ugwu, Suk Dev Regmi, Julie M Nogee, James M Cheverud
Despite decades of progress, congenital heart disease remains a major cause of mortality and suffering in children and young adults. Prevention would be ideal, but formidable biological and technical hurdles face any intervention that seeks to target the main causes, genetic mutations in the embryo. Other factors, however, significantly modify the total risk in individuals who carry mutations. Investigation of these factors could lead to an alternative approach to prevention. To define the risk modifiers, our group has taken an "experimental epidemiologic" approach via inbred mouse strain crosses...
November 5, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27431419/cardiac-patients-show-high-interest-in-technology-enabled-cardiovascular-rehabilitation
#10
Roselien Buys, Jomme Claes, Deirdre Walsh, Nils Cornelis, Kieran Moran, Werner Budts, Catherine Woods, Véronique A Cornelissen
BACKGROUND: Cardiac rehabilitation (CR) can slow or reverse the progression of cardiovascular disease (CVD). However, uptake of community-based CR is very low. E-cardiology, e-health and technology solutions for physical activity uptake and monitoring have evolved rapidly and have potential in CVD management. However, it is unclear what the current technology usage is of CVD patients, and their needs and interests for technology enabled CR. METHODS: A technology usage questionnaire was developed and completed by patients from a supervised ambulatory CR program and an adult congenital heart disease clinic and from two community-based CR programs...
2016: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/27428818/association-between-depressive-symptoms-and-exercise-capacity-in-patients-with-heart-disease-a-meta-analysis
#11
Theodoros Papasavvas, Mohammad Alhashemi, Dominic Micklewright
PURPOSE: Depression and reduced exercise capacity are risk factors for poor prognosis in patients with heart disease, but the relationship between the 2 is unclear. We assessed the relationship between depressive symptoms and exercise capacity in patients with heart disease. METHODS: PubMed, Cochrane Library, Google Scholar, and ProQuest databases were browsed for English-language studies published from January 2000 to September 2013. Studies including adult patients with coronary artery disease, heart failure, congenital heart disease, and implantable cardioverter defibrillator, reporting correlation between a depression scale and exercise capacity (VO2peak, peak watts, estimated metabolic equivalents, and incremental shuttle walk test distance), as well as studies from which such a correlation could be calculated and provided by the authors, were included...
July 14, 2016: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/27125263/fenestrated-transcatheter-asd-closure-in-adults-with-diastolic-dysfunction-and-or-pulmonary-hypertension-case-series-and-review-of-the-literature
#12
Ayman Abdelkarim, Daniel S Levi, Bao Tran, Joanna Ghobrial, Jamil Aboulhosn
OBJECTIVES: This study aims to evaluate the safety and efficacy of transcatheter fenestrated ASD closure and to summarize the literature regarding the published techniques and outcomes of transcatheter partial ASD closure. BACKGROUND: Patients with left ventricular diastolic dysfunction (LVDD) or right ventricular (RV) dysfunction and/or pulmonary hypertension (PHT) may suffer untoward consequences of complete closure of an ostium secundum atrial septal defect (ASD)...
December 2016: Congenital Heart Disease
https://www.readbyqxmd.com/read/27099763/effect-of-dual-pulmonary-vasodilator-therapy-in-pulmonary-arterial-hypertension-associated-with-congenital-heart-disease-a-retrospective-analysis
#13
Oliver Monfredi, Elliot Heward, Linda Griffiths, Robin Condliffe, Vaikom S Mahadevan
BACKGROUND: Patients with pulmonary arterial hypertension (PAH) are managed according to evidence-based treatment guidelines. METHODS AND RESULTS: In this single-centre retrospective analysis, we examined outcomes of patients with PAH caused by congenital heart disease (PAH-CHD) with respect to exercise capacity and survival of adults treated with either bosentan or sildenafil monotherapy or bosentan-sildenafil dual therapy between January 2007 and January 2014...
2016: Open Heart
https://www.readbyqxmd.com/read/27060997/lifestyle-habits-among-adult-congenital-heart-disease-patients-in-malta
#14
Maryanne Caruana, Victor Grech
OBJECTIVE: Adult congenital heart disease patients are prone to health risk behaviors like their peers. Such behaviors can have serious implications, particularly in patients with complex congenital lesions. We investigated patterns in tobacco smoking, alcohol consumption, substance misuse, dental reviews, and physical activity in Maltese patients. DESIGN: A questionnaire modeled on the 2008 European Health Interview Survey was offered to consecutive adult congenital heart disease outpatients, aged 16 years and over, between May 2013 and May 2014...
July 2016: Congenital Heart Disease
https://www.readbyqxmd.com/read/27043063/heart-failure-with-preserved-right-ventricular-ejection-fraction-in-postoperative-adults-with-congenital-heart-disease-a-subtype-of-severe-right-ventricular-pathophysiology
#15
Hideo Ohuchi, Yosuke Hayama, Jun Negishi, Kanae Noritake, Toru Iwasa, Aya Miyazaki, Osamu Yamada, Isao Shiraishi
BACKGROUND: Right ventricle (RV) may determine heart failure (HF) severity in adults with congenital heart disease (ACHD). However, the association of RV properties with clinical profiles remains unclear. PURPOSE: To clarify the associations of RV properties with biomarkers, exercise capacity, and unscheduled hospitalization (USH) in postoperative ACHD patients. METHODS AND RESULTS: We evaluated determinants of RV end-diastolic volume (EDVI, ml/m(2)) and pressure (EDP, mmHg) in 260 patients who were divided into 4 groups, i...
June 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/26984567/treatment-of-pulmonary-arterial-hypertension-in-congenital-heart-disease-in-singapore-versus-the-netherlands-age-exceeds-ethnicity-in-influencing-clinical-outcome
#16
A C M J van Riel, M J Schuuring, I D van Hessen, A P J van Dijk, E S Hoendermis, J W Yip, B J M Mulder, B J Bouma
BACKGROUND: Advanced treatment of pulmonary arterial hypertension (PAH) in congenital heart disease (CHD) is increasingly applied worldwide following the-mainly Western world based-international PAH-CHD guidelines. However, studies comparing clinical presentation and outcome after the initiation of PAH-specific treatment are lacking. We aimed to analyse this in a Singaporean and Dutch cohort of PAH-CHD patients. METHODS: Adult CHD patients starting PAH-specific therapy, enrolled in two nationwide registries, were analysed...
June 2016: Netherlands Heart Journal
https://www.readbyqxmd.com/read/26983903/matrix-metalloproteinases-as-candidate-biomarkers-in-adults-with-congenital-heart-disease
#17
Vivan J M Baggen, Jannet A Eindhoven, Annemien E van den Bosch, Maarten Witsenburg, Judith A A E Cuypers, Jannette S Langstraat, Eric Boersma, Jolien W Roos-Hesselink
Context Matrix metalloproteinases (MMPs) are associated with diastolic dysfunction and heart failure in acquired heart disease. Objective To investigate the role of MMPs as novel biomarkers in clinically stable adults with congenital heart disease. Methods We measured serum MMP-2, -3, -9 and tissue inhibitor of matrix metalloproteinase-1 in 425 patients and analysed the association with cardiac function and exercise capacity. Results MMP-2 was significantly associated with exercise capacity, ventilatory efficiency and left ventricular deceleration time, independently of age, sex, body surface area and NT-proBNP...
July 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/26887607/cardiovascular-physiology-and-disease-in-youth
#18
Thomas Rowland
No abstract text is available yet for this article.
February 2016: Pediatric Exercise Science
https://www.readbyqxmd.com/read/26868839/risks-and-benefits-of-exercise-training-in-adults-with-congenital-heart-disease
#19
REVIEW
Marie-A Chaix, François Marcotte, Annie Dore, François-Pierre Mongeon, Blandine Mondésert, Lise-Andrée Mercier, Paul Khairy
Exercise capacity in adults with various forms of congenital heart disease is substantially lower than that of the general population. Although the underlying congenital heart defect, and its sequelae, certainly contribute to observed exercise limitations, there is evidence suggesting that deconditioning and a sedentary lifestyle are important implicated factors. The prevalence of acquired cardiovascular comorbidities is on the increase in the aging population with congenital heart disease, such that obesity and a sedentary lifestyle confer increased risk...
April 2016: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/26777265/habitual-physical-activity-in-adults-with-congenital-heart-disease-compared-with-age-and-sex-matched-controls
#20
Camilla Sandberg, Jeremy Pomeroy, Ulf Thilén, Anna Gradmark, Karin Wadell, Bengt Johansson
BACKGROUND: Most adult patients with congenital heart disease (CHD) have reduced aerobic exercise capacity. Their habitual physical activity (PA) level is, however, less well studied. In this study, habitual PA level in a cohort of adults with CHD compared with healthy age- and sex-matched controls was investigated. METHODS: Eighty adults with CHD, classed as either "complex" (n = 40) or "simple" (n = 40), and 42 healthy controls were studied with a combined uniaxial accelerometer and heart rate monitor worn during 4 consecutive days...
April 2016: Canadian Journal of Cardiology
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