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Exercise adult congenital heart disease

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https://www.readbyqxmd.com/read/27620913/nt-probnp-and-exercise-capacity-in-adult-patients-with-congenital-heart-disease-and-a%C3%A2-prosthetic-valve-a%C3%A2-multicentre-prostava-study
#1
R C Schoonbeek, P G Pieper, Y J van Slooten, H G Freling, G T Sieswerda, A P J van Dijk, M R M Jongbloed, M C Post, B J Bouma, R M F Berger, T Ebels, J P van Melle
OBJECTIVES: N-terminal B‑type natriuretic peptide (NT-proBNP) is an important biomarker for the detection of heart failure. Adults with congenital heart disease (ACHD) and a prosthetic heart valve are at risk for heart failure. This study aimed to determine the value of NT-proBNP in ACHD patients with a prosthetic valve and investigate its relationship with cardiac function and exercise capacity. METHODS: In this multi-centre cross-sectional observational study, data regarding medical history, echocardiography, exercise testing (VO2peak) and laboratory blood evaluation (including NT-proBNP) were collected in ACHD patients with a single prosthetic valve (either homografts, heterografts or mechanical valves)...
November 2016: Netherlands Heart Journal
https://www.readbyqxmd.com/read/27555292/transgenerational-cardiology-one-way-to-a-baby-s-heart-is-through-the-mother
#2
Patrick Y Jay, Ehiole Akhirome, Rachel A Magnan, M Rebecca Zhang, Lillian Kang, Yidan Qin, Nelson Ugwu, Suk Dev Regmi, Julie M Nogee, James M Cheverud
Despite decades of progress, congenital heart disease remains a major cause of mortality and suffering in children and young adults. Prevention would be ideal, but formidable biological and technical hurdles face any intervention that seeks to target the main causes, genetic mutations in the embryo. Other factors, however, significantly modify the total risk in individuals who carry mutations. Investigation of these factors could lead to an alternative approach to prevention. To define the risk modifiers, our group has taken an "experimental epidemiologic" approach via inbred mouse strain crosses...
November 5, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27431419/cardiac-patients-show-high-interest-in-technology-enabled-cardiovascular-rehabilitation
#3
Roselien Buys, Jomme Claes, Deirdre Walsh, Nils Cornelis, Kieran Moran, Werner Budts, Catherine Woods, Véronique A Cornelissen
BACKGROUND: Cardiac rehabilitation (CR) can slow or reverse the progression of cardiovascular disease (CVD). However, uptake of community-based CR is very low. E-cardiology, e-health and technology solutions for physical activity uptake and monitoring have evolved rapidly and have potential in CVD management. However, it is unclear what the current technology usage is of CVD patients, and their needs and interests for technology enabled CR. METHODS: A technology usage questionnaire was developed and completed by patients from a supervised ambulatory CR program and an adult congenital heart disease clinic and from two community-based CR programs...
2016: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/27428818/association-between-depressive-symptoms-and-exercise-capacity-in-patients-with-heart-disease-a-meta-analysis
#4
Theodoros Papasavvas, Mohammad Alhashemi, Dominic Micklewright
PURPOSE: Depression and reduced exercise capacity are risk factors for poor prognosis in patients with heart disease, but the relationship between the 2 is unclear. We assessed the relationship between depressive symptoms and exercise capacity in patients with heart disease. METHODS: PubMed, Cochrane Library, Google Scholar, and ProQuest databases were browsed for English-language studies published from January 2000 to September 2013. Studies including adult patients with coronary artery disease, heart failure, congenital heart disease, and implantable cardioverter defibrillator, reporting correlation between a depression scale and exercise capacity (VO2peak, peak watts, estimated metabolic equivalents, and incremental shuttle walk test distance), as well as studies from which such a correlation could be calculated and provided by the authors, were included...
July 14, 2016: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/27125263/fenestrated-transcatheter-asd-closure-in-adults-with-diastolic-dysfunction-and-or-pulmonary-hypertension-case-series-and-review-of-the-literature
#5
Ayman Abdelkarim, Daniel S Levi, Bao Tran, Joanna Ghobrial, Jamil Aboulhosn
OBJECTIVES: This study aims to evaluate the safety and efficacy of transcatheter fenestrated ASD closure and to summarize the literature regarding the published techniques and outcomes of transcatheter partial ASD closure. BACKGROUND: Patients with left ventricular diastolic dysfunction (LVDD) or right ventricular (RV) dysfunction and/or pulmonary hypertension (PHT) may suffer untoward consequences of complete closure of an ostium secundum atrial septal defect (ASD)...
December 2016: Congenital Heart Disease
https://www.readbyqxmd.com/read/27099763/effect-of-dual-pulmonary-vasodilator-therapy-in-pulmonary-arterial-hypertension-associated-with-congenital-heart-disease-a-retrospective-analysis
#6
Oliver Monfredi, Elliot Heward, Linda Griffiths, Robin Condliffe, Vaikom S Mahadevan
BACKGROUND: Patients with pulmonary arterial hypertension (PAH) are managed according to evidence-based treatment guidelines. METHODS AND RESULTS: In this single-centre retrospective analysis, we examined outcomes of patients with PAH caused by congenital heart disease (PAH-CHD) with respect to exercise capacity and survival of adults treated with either bosentan or sildenafil monotherapy or bosentan-sildenafil dual therapy between January 2007 and January 2014...
2016: Open Heart
https://www.readbyqxmd.com/read/27060997/lifestyle-habits-among-adult-congenital-heart-disease-patients-in-malta
#7
Maryanne Caruana, Victor Grech
OBJECTIVE: Adult congenital heart disease patients are prone to health risk behaviors like their peers. Such behaviors can have serious implications, particularly in patients with complex congenital lesions. We investigated patterns in tobacco smoking, alcohol consumption, substance misuse, dental reviews, and physical activity in Maltese patients. DESIGN: A questionnaire modeled on the 2008 European Health Interview Survey was offered to consecutive adult congenital heart disease outpatients, aged 16 years and over, between May 2013 and May 2014...
July 2016: Congenital Heart Disease
https://www.readbyqxmd.com/read/27043063/heart-failure-with-preserved-right-ventricular-ejection-fraction-in-postoperative-adults-with-congenital-heart-disease-a-subtype-of-severe-right-ventricular-pathophysiology
#8
Hideo Ohuchi, Yosuke Hayama, Jun Negishi, Kanae Noritake, Toru Iwasa, Aya Miyazaki, Osamu Yamada, Isao Shiraishi
BACKGROUND: Right ventricle (RV) may determine heart failure (HF) severity in adults with congenital heart disease (ACHD). However, the association of RV properties with clinical profiles remains unclear. PURPOSE: To clarify the associations of RV properties with biomarkers, exercise capacity, and unscheduled hospitalization (USH) in postoperative ACHD patients. METHODS AND RESULTS: We evaluated determinants of RV end-diastolic volume (EDVI, ml/m(2)) and pressure (EDP, mmHg) in 260 patients who were divided into 4 groups, i...
June 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/26984567/treatment-of-pulmonary-arterial-hypertension-in-congenital-heart-disease-in-singapore-versus-the-netherlands-age-exceeds-ethnicity-in-influencing-clinical-outcome
#9
A C M J van Riel, M J Schuuring, I D van Hessen, A P J van Dijk, E S Hoendermis, J W Yip, B J M Mulder, B J Bouma
BACKGROUND: Advanced treatment of pulmonary arterial hypertension (PAH) in congenital heart disease (CHD) is increasingly applied worldwide following the-mainly Western world based-international PAH-CHD guidelines. However, studies comparing clinical presentation and outcome after the initiation of PAH-specific treatment are lacking. We aimed to analyse this in a Singaporean and Dutch cohort of PAH-CHD patients. METHODS: Adult CHD patients starting PAH-specific therapy, enrolled in two nationwide registries, were analysed...
June 2016: Netherlands Heart Journal
https://www.readbyqxmd.com/read/26983903/matrix-metalloproteinases-as-candidate-biomarkers-in-adults-with-congenital-heart-disease
#10
Vivan J M Baggen, Jannet A Eindhoven, Annemien E van den Bosch, Maarten Witsenburg, Judith A A E Cuypers, Jannette S Langstraat, Eric Boersma, Jolien W Roos-Hesselink
Context Matrix metalloproteinases (MMPs) are associated with diastolic dysfunction and heart failure in acquired heart disease. Objective To investigate the role of MMPs as novel biomarkers in clinically stable adults with congenital heart disease. Methods We measured serum MMP-2, -3, -9 and tissue inhibitor of matrix metalloproteinase-1 in 425 patients and analysed the association with cardiac function and exercise capacity. Results MMP-2 was significantly associated with exercise capacity, ventilatory efficiency and left ventricular deceleration time, independently of age, sex, body surface area and NT-proBNP...
July 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/26887607/cardiovascular-physiology-and-disease-in-youth
#11
Thomas Rowland
No abstract text is available yet for this article.
February 2016: Pediatric Exercise Science
https://www.readbyqxmd.com/read/26868839/risks-and-benefits-of-exercise-training-in-adults-with-congenital-heart-disease
#12
REVIEW
Marie-A Chaix, François Marcotte, Annie Dore, François-Pierre Mongeon, Blandine Mondésert, Lise-Andrée Mercier, Paul Khairy
Exercise capacity in adults with various forms of congenital heart disease is substantially lower than that of the general population. Although the underlying congenital heart defect, and its sequelae, certainly contribute to observed exercise limitations, there is evidence suggesting that deconditioning and a sedentary lifestyle are important implicated factors. The prevalence of acquired cardiovascular comorbidities is on the increase in the aging population with congenital heart disease, such that obesity and a sedentary lifestyle confer increased risk...
April 2016: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/26777265/habitual-physical-activity-in-adults-with-congenital-heart-disease-compared-with-age-and-sex-matched-controls
#13
Camilla Sandberg, Jeremy Pomeroy, Ulf Thilén, Anna Gradmark, Karin Wadell, Bengt Johansson
BACKGROUND: Most adult patients with congenital heart disease (CHD) have reduced aerobic exercise capacity. Their habitual physical activity (PA) level is, however, less well studied. In this study, habitual PA level in a cohort of adults with CHD compared with healthy age- and sex-matched controls was investigated. METHODS: Eighty adults with CHD, classed as either "complex" (n = 40) or "simple" (n = 40), and 42 healthy controls were studied with a combined uniaxial accelerometer and heart rate monitor worn during 4 consecutive days...
April 2016: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/26690295/sexual-activity-and-heart-patients-a-contemporary-perspective
#14
REVIEW
Ricardo Stein, Aline Sardinha, Claudio Gil S Araújo
Sexual activity (SA) encompasses several behaviors such as kissing (Ki), touching (T), oral (O) stimulation, masturbation (M), and vaginal/anal intercourse (I). The acronym KiTOMI is proposed here to represent these behaviors. SA, particularly coitus, is a major aspect of health-related quality of life and is often considered the most pleasant and rewarding exercise performed during an entire lifetime. Although several studies have been conducted on sexuality, relatively limited information is available regarding SA in patients with heart disease...
April 2016: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/26638054/correlation-between-cardio-pulmonary-exercise-test-variables-and-health-related-quality-of-life-among-children-with-congenital-heart-diseases
#15
P Amedro, M C Picot, S Moniotte, R Dorka, H Bertet, S Guillaumont, C Barrea, M Vincenti, G De La Villeon, C Bredy, C Soulatges, M Voisin, S Matecki, P Auquier
BACKGROUND: Health-related quality of life (HR-QoL) stands as a determinant "patient-related outcome" and correlates with cardio-pulmonary exercise test (CPET) in adults with chronic heart failure or with a congenital heart disease (CHD). No such correlation has been established in pediatric cardiology. METHODS AND RESULTS: 202 CHD children aged 8 to 18 performed a CPET (treadmill n=96, cycle-ergometer n=106). CHD severity was stratified into 4 groups. All children and parents filled out the Kidscreen HR-QoL questionnaire...
January 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/26596791/aortic-valve-prosthesis-patient-mismatch-and-exercise-capacity-in-adult-patients-with-congenital-heart-disease
#16
Ymkje J van Slooten, Joost P van Melle, Hendrik G Freling, Berto J Bouma, Arie Pj van Dijk, Monique Rm Jongbloed, Martijn C Post, Gertjan T Sieswerda, Anna Huis In 't Veld, Tjark Ebels, Adriaan A Voors, Petronella G Pieper
OBJECTIVES: To report the prevalence of aortic valve prosthesis-patient mismatch (PPM) in an adult population with congenital heart disease (CHD) and its impact on exercise capacity. Adults with congenital heart disease (ACHD) with a history of aortic valve replacement may outgrow their prosthesis later in life. However, the prevalence and clinical consequences of aortic PPM in ACHD are presently unknown. METHODS: From the national Dutch Congenital Corvitia (CONCOR) registry, we identified 207 ACHD with an aortic valve prosthesis for this cross-sectional cohort study...
January 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/26471822/heart-failure-in-adult-congenital-heart-disease-nonpharmacologic-treatment-strategies
#17
REVIEW
Lisa LeMond, Tuan Mai, Craig S Broberg, Ashok Muralidaran, Luke J Burchill
In early stages, heart failure (HF) in adult congenital heart disease (ACHD) remains an elusive diagnosis. Many ACHD patients seem well-compensated owing to chronic physical and psychological adaptations. HF biomarkers and cardiopulmonary exercise tests are often markedly abnormal, although patients report stable health and good quality of life. Treatment differs from acquired HF. Evidence for effective drug therapy in ACHD-related HF is lacking. Residual ventricular, valvular, and vascular abnormalities contribute to HF pathophysiology, leading to an emphasis on nonpharmacologic treatment strategies...
November 2015: Cardiology Clinics
https://www.readbyqxmd.com/read/26413110/analysis-of-cardiovascular-risk-factors-in-adults-with-congenital-heart-disease
#18
Ju Ryoung Moon, Jinyoung Song, June Huh, I-Seok Kang, Seung Woo Park, Sung-A Chang, Ji-Hyuk Yang, Tae-Gook Jun
BACKGROUND AND OBJECTIVES: The objective of this study was to analyze cardiovascular risk factors in adults with congenital heart disease (ACHD). SUBJECTS AND METHODS: The subjects for this study comprised 135 patients, aged 18 years and above, who visited the ACHD clinic at the Samsung Medical Center and 135 adults with a structurally normal heart who were randomly selected from the Center for Health Promotion during the same period. For the analysis, the ACHD group was further divided into an ACHD group that underwent correction by cardiac surgery and a cyanotic group...
September 2015: Korean Circulation Journal
https://www.readbyqxmd.com/read/26385046/does-exercise-training-improve-cardiopulmonary-fitness-and-daily-physical-activity-in-children-and-young-adults-with-corrected-tetralogy-of-fallot-or-fontan-circulation-a-randomized-controlled-trial
#19
RANDOMIZED CONTROLLED TRIAL
Nienke Duppen, Jonathan R Etnel, Laura Spaans, Tim Takken, Rita J van den Berg-Emons, Eric Boersma, Michiel Schokking, Karolijn Dulfer, Elisabeth M Utens, Willem Helbing, Maria T Hopman
BACKGROUND: Many patients with congenital heart disease do not meet current public health guidelines to participate in moderate-to-vigorous physical activity for ≥60 minutes per day. They are less fit than their healthy peers. We hypothesized that exercise training would increase cardiopulmonary fitness and daily physical activity in these patients. We therefore assessed effects of an exercise training program on cardiopulmonary fitness and daily physical activity in patients with corrected tetralogy of Fallot (ToF) or Fontan circulation...
September 2015: American Heart Journal
https://www.readbyqxmd.com/read/26334385/exercise-capacity-and-cardiac-function-after-surgical-closure-of-ventricular-septal-defect-is-there-unrecognized-long-term-morbidity
#20
REVIEW
Johan Heiberg, Andrew Redington, Vibeke E Hjortdal
Adult survivors of congenital heart disease form a continuously growing population, as each successive cohort graduating from pediatric care expands the total number of patients worldwide. Consequently, there is an increasing interest and study of their late pathophysiology, the understanding of which can only truly be understood during very long-term follow-up. Indeed, we have already learned that, for some patient groups, hitherto unexpected problems may only develop decades after surgery. Consequently, many patients require careful follow-up in ACHD clinics throughout life...
December 15, 2015: International Journal of Cardiology
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