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Myd88 lung caner

Chao Yuan, Yisheng Zheng, Bo Zhang, LiJuan Shao, Yang Liu, Tian Tian, XiaoBin Gu, Xiangnan Li, KeXing Fan
Thymosin α1 (Tα1) has been tested for cancer therapy for several years, in most cases, the anti-tumor effect of Tα1 was limited, especially when Tα1 was used as a single agent. The role of Tα1 in cancer treatment and the regulatory mechanisms by which Ta1 takes effects are not yet completely understood. Using a Lewis lung caner model, here we report that Tα1 used alone elevated CD8(+) T cells, but failed to inhibit tumor growth. Furthermore, immunosuppressive myeloid-derived suppressor cells (MDSCs) showed heightened Arginase 1 production in response to Tα1 treatment, which led to stronger suppression of anti-tumor immunity...
August 14, 2015: Biochemical and Biophysical Research Communications
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