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https://www.readbyqxmd.com/read/28929711/-statistics-at-the-time-of-the-crisis
#1
Andrea Saltelli, Philip B Stark
Science lies nowadays in the centre of several storms. The better known is the finding of non-reproducibility of many scientific results, which stretches from the medical field (clinic and pre-clinic tests) to study on behaviour (priming research). Although the bad use of statistics is reported to be a patent cause of the reproducibility crisis, its deep reasons are to be sought elsewhere; particularly, in the passage from a regimen of little science - regulated by small communities of researchers - to the current big science - identified by a hypertrophic production of millions of research papers and by the imperative "publish or perish", in a setting dominated by market...
May 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/28924152/second-harmonic-generation-response-in-thermally-reconstructed-multiferroic-%C3%AE-gd2-moo4-3-thin-films
#2
Emerson Coy, Piotr Graczyk, Luis Yate, Karol Załęski, Jacek Gapiński, Piotr Kuświk, Sławomir Mielcarek, Feliks Stobiecki, Bogusław Mróz, Cesar Ferrater, Stefan Jurga
Gd2(MoO4)3 (GMO) is a well-studied multiferroic material that exhibits full ferroelectric and ferroelastic behavior at room temperature. However, its difficult stabilization in thin films has prevented the study and exploitation of its multiferroic properties in different architectures. Here, we report on the study of GMO thin films deposited on Si(001) substrates by Pulsed Laser Deposition (PLD). The physicochemical properties of the films are discussed and studied. Results obtained by X-ray diffraction, X-ray photoelectron spectroscopy, high resolution transmission microscopy and second harmonic generation show that the orthorhombic (β'-GMO) multiferroic phase can be stabilized and homogenized by post deposition thermal reconstruction...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28866460/nitric-oxide-sensing-actuators-for-modulating-structure-in-lipid-based-liquid-crystalline-drug-delivery-systems
#3
Qingtao Liu, Jinming Hu, Michael R Whittaker, Thomas P Davis, Ben J Boyd
Herein we report on the development of a nitric oxide-sensing lipid-based liquid crystalline (LLC) system specifically designed to release encapsulated drugs on exposure to NO through a stimulated phase change. A series of nitric oxide (NO)-sensing lipids compatible with phytantriol and GMO cubic phases were designed and synthesized, and utilized in enabling nitric oxide-sensing LLC systems. The nitric oxide (NO)-sensing lipids react with nitric oxide, resulting in hydrolysis of these lipids and phase transition of the LLC system...
August 24, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28859885/case-studies-on-genetically-modified-organisms-gmos-potential-risk-scenarios-and-associated-health-indicators
#4
Barbara De Santis, Norbert Stockhofe, Jean-Michel Wal, Eefke Weesendorp, Jean Paul Lallès, Jeroen van Dijk, Esther Kok, Marzia De Giacomo, Ralf Einspanier, Roberta Onori, Carlo Brera, Paul Bikker, Jan van der Meulen, Kleter Gijs
Within the frame of the EU-funded MARLON project, background data were reviewed to explore the possibility of measuring health indicators during post-market monitoring for potential effects of feeds, particularly genetically modified (GM) feeds, on livestock animal health, if applicable. Four case studies (CSs) of potential health effects on livestock were framed and the current knowledge of a possible effect of GM feed was reviewed. Concerning allergenicity (CS-1), there are no case-reports of allergic reactions or immunotoxic effects resulting from GM feed consumption as compared with non-GM feed...
August 28, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28819142/development-and-inter-laboratory-assessment-of-droplet-digital-pcr-assays-for-multiplex-quantification-of-15-genetically-modified-soybean-lines
#5
Alexandra Bogožalec Košir, Bjørn Spilsberg, Arne Holst-Jensen, Jana Žel, David Dobnik
Quantification of genetically modified organisms (GMOs) in food and feed products is often required for their labelling or for tolerance thresholds. Standard-curve-based simplex quantitative polymerase chain reaction (qPCR) is the prevailing technology, which is often combined with screening analysis. With the rapidly growing number of GMOs on the world market, qPCR analysis becomes laborious and expensive. Innovative cost-effective approaches are therefore urgently needed. Here, we report the development and inter-laboratory assessment of multiplex assays to quantify GMO soybean using droplet digital PCR (ddPCR)...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28794904/qbd-based-approach-for-optimization-of-tenofovir-disoproxil-fumarate-loaded-liquid-crystal-precursor-with-improved-permeability
#6
Sharvil Patil, Chandrashekhar Kadam, Varsha Pokharkar
BCS class III drugs suffer from a drawback of low permeability even though they have high aqueous solubility. The objective of current work was to screen the suitability of glyceryl monooleate (GMO)/Pluronic F127 cubic phase liquid crystals precursors for permeation enhancement and in turn the bioavailability of tenofovir disoproxil fumarate (TDF), a BCS class III drug. Spray-drying method was used for preparation of TDF loaded liquid crystal precursors (LCP) consisting of GMO/Pluronic F127 and lactose monohydrate with an ability to in situ transform into stable cubic phases upon hydration...
November 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28703317/organic-meat-quality-of-dual-purpose-young-bulls-supplemented-with-pea-pisum-sativum-l-or-soybean
#7
Mirco Corazzin, Edi Piasentier, Elena Saccà, Ilario Bazzoli, Stefano Bovolenta
BACKGROUND: One of the main constraints established by organic legislation that limits the development of the rearing of young bulls is the ban on the use of genetically modified organisms (GMO). Most of the worldwide cultivated soybean is GMO, therefore the use of alternative protein sources should be evaluated. In this study, the effect of dietary substitution of soybean with pea (Pisum sativum L.) on carcass characteristics and meat quality of dual purpose young bulls reared following the organic method was investigated...
July 12, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28680789/is-it-only-the-regulatory-status-broadening-the-debate-on-cisgenic-plants
#8
Lilian van Hove, Frøydis Gillund
In current debates on emerging technologies for plant breeding in Europe, much attention has been given to the regulatory status of these techniques and their public acceptance. At present, both genetically modified plants with cisgenic approaches-using genes from crossable species-as well as transgenic approaches-using genes from different species-fall under GMO regulation in the EU and both are mandatorily labelled as GMOs. Researchers involved in the early development of cisgenic GM plants convey the message that the potential use and acceptance of cisgenic approaches will be seriously hindered if GMO regulations are not adjusted...
2017: Environmental Sciences Europe
https://www.readbyqxmd.com/read/28667838/quantitative-ratiometric-phosphorescence-hypoxia-sensing-nanoprobes-based-on-quantum-dots-ir-iii-glycerol-monoolein-cubic-phase-nanoparticles
#9
Jiajun Liu, Youshen Wu, Yao Yu, Ke Li, Yuanyuan Ji, Daocheng Wu
A novel protocol is developed to prepare quantum dot (QD)/Ir(III) complex glycerol monoolein (GMO) cubic-phase nanoparticles (Qd/Ir GMCPNPs) as hypoxia nanoprobes, in which hypoxia probe Tris [1-phenylisoquinoline-C2, N] Iridium(III) [Ir(piq)3] and the reference QDs are separately loaded at hydrophilic and hydrophobic channels to avoid interference. Qd/Ir GMCPNPs were nearly spherical in shape, with an average size of 20-30nm. Their phosphorescence spectra showed that nanoprobes have a wide excited wave length range of 360-500nm, which is suitable for different types of measurement instruments...
June 24, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28661256/food-labeling-and-consumer-associations-with-health-safety-and-environment
#10
Joanna K Sax, Neal Doran
The food supply is complicated and consumers are increasingly calling for labeling on food to be more informative. In particular, consumers are asking for the labeling of food derived from genetically modified organisms (GMO) based on health, safety, and environmental concerns. At issue is whether the labels that are sought would accurately provide the information desired. The present study examined consumer (n = 181) perceptions of health, safety and the environment for foods labeled organic, natural, fat free or low fat, GMO, or non-GMO...
December 2016: Journal of Law, Medicine & Ethics: a Journal of the American Society of Law, Medicine & Ethics
https://www.readbyqxmd.com/read/28647548/the-bioeconomy-in-poland-within-the-context-of-the-european-union
#11
REVIEW
Ewa Woźniak, Tomasz Twardowski
This article outlines the potential of the development of bioeconomy in Poland in the context of the European Union (EU). The analyses take into account the concept of bioeconomy, the overview of documents referring to the bioeconomy in the EU, including policy frameworks and agendas. Many countries including Poland emphasise the importance of bioeconomy, but have not yet developed a complex strategy. The state of bioeconomy in Poland is characterised by the sectors of agriculture, forestry and food production, as well as parts of the chemical, biotechnology and energy industries...
June 21, 2017: New Biotechnology
https://www.readbyqxmd.com/read/28645870/impact-on-environment-ecosystem-diversity-and-health-from-culturing-and-using-gmos-as-feed-and-food
#12
REVIEW
Aristidis M Tsatsakis, Muhammad Amjad Nawaz, Victor A Tutelyan, Kirill S Golokhvast, Olga-Ioanna Kalantzi, Duck Hwa Chung, Sung Jo Kang, Michael D Coleman, Nadia Tyshko, Seung Hwan Yang, Gyuhwa Chung
Modern agriculture provides the potential for sustainable feeding of the world's increasing population. Up to the present moment, genetically modified (GM) products have enabled increased yields and reduced pesticide usage. Nevertheless, GM products are controversial amongst policy makers, scientists and the consumers, regarding their possible environmental, ecological, and health risks. Scientific-and-political debates can even influence legislation and prospective risk assessment procedure. Currently, the scientifically-assessed direct hazardous impacts of GM food and feed on fauna and flora are conflicting; indeed, a review of literature available data provides some evidence of GM environmental and health risks...
September 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28510305/reactive-precipitation-of-anhydrous-alkali-sulfide-nanocrystals-with-concomitant-abatement-of-hydrogen-sulfide-and-cogeneration-of-hydrogen
#13
Xuemin Li, Yangzhi Zhao, Alice Brennan, Miranda McCeig, Colin A Wolden, Yongan Yang
Anhydrous alkali sulfide (M2 S, M=Li or Na) nanocrystals (NCs) are important materials central to the development of next generation cathodes and solid-state electrolytes for advanced batteries, but not commercially available at present. This work reports an innovative method to directly synthesize M2 S NCs through alcohol-mediated reactions between alkali metals and hydrogen sulfide (H2 S). In the first step, the alkali metal is complexed with alcohol in solution, forming metal alkoxide (ROM) and releasing hydrogen (H2 )...
July 21, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28500978/novel-polyglycerol-dioleate-based-cubosomal-dispersion-with-tailored-physical-characteristics-for-controlled-delivery-of-ondansetron
#14
M Mansour, A O Kamel, S Mansour, N D Mortada
In this study different amphiphilic lipids viz. glycerylmonooleate (GMO), Glycerylmonolinoleate (GML), Plurol(®) (polyglycerol 3-dioleate), Soya phosphatidylcholine (Soya PC), Dipalmitoyl-phosphatidylcholine (DPPC) and Dipalmitoyl- phosphatidylglycerol (DPPG) were screened for their ability to form cubosomes and the formed particles were optimized for controlled delivery using ondansetron as a model drug. Polarized optical microscopy and high resolution transmission electron microscopy were performed to investigate the morphology of the prepared particles...
April 26, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28490084/an-integrated-strategy-combining-dna-walking-and-ngs-to-detect-gmos
#15
Marie-Alice Fraiture, Philippe Herman, Nina Papazova, Marc De Loose, Dieter Deforce, Tom Ruttink, Nancy H Roosens
Recently, we developed a DNA walking system for the detection and characterization of a broad spectrum of GMOs in routine analysis of food/feed matrices. Here, we present a new version with improved throughput and sensitivity by coupling the DNA walking system to Pacific Bioscience® Next-generation sequencing technology. The performance of the new strategy was thoroughly assessed through several assays. First, we tested its detection and identification capability on grains with high or low GMO content. Second, the potential impacts of food processing were investigated using rice noodle samples...
October 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28479357/hexagonal-liquid-crystalline-nanodispersions-proven-superiority-for-enhanced-oral-delivery-of-rosuvastatin-in%C3%A2-vitro-characterization-and-in%C3%A2-vivo-pharmacokinetic-study
#16
Mai Mahmoud Gabr, Sana Mohamed Mortada, Marwa Ahmed Sallam
This study aimed to explore the potential of tailoring the liquid crystalline structure for augmenting the oral absorption and biopharmaceutical performance of rosuvastatin. Rosuvastatin (ROS)-loaded liquid crystalline nanodispersions (LCNDs) were prepared via emulsification technique. The effect of incorporating oleic acid (OA) in various proportions in the lipid domain of the LCNDs was studied. The formulations were characterized for particle size, zeta potential, in vitro release, ex vivo intestinal permeation, in vivo oral bioavailability, and stability...
May 4, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28420193/a-quantitative-pcr-electrochemical-genosensor-test-for-the-screening-of-biotech-crops
#17
Suely Moura-Melo, Rebeca Miranda-Castro, Noemí de-Los-Santos-Álvarez, Arturo J Miranda-Ordieres, José Ribeiro Dos Santos Junior, Rosana A da Silva Fonseca, María Jesús Lobo-Castañón
The design of screening methods for the detection of genetically modified organisms (GMOs) in food would improve the efficiency in their control. We report here a PCR amplification method combined with a sequence-specific electrochemical genosensor for the quantification of a DNA sequence characteristic of the 35S promoter derived from the cauliflower mosaic virus (CaMV). Specifically, we employ a genosensor constructed by chemisorption of a thiolated capture probe and p-aminothiophenol gold surfaces to entrap on the sensing layer the unpurified PCR amplicons, together with a signaling probe labeled with fluorescein...
April 18, 2017: Sensors
https://www.readbyqxmd.com/read/28417173/semiautomated-taqman-pcr-screening-of-gmo-labelled-samples-for-unauthorised-gmos
#18
Ingrid M J Scholtens, Bonnie Molenaar, Richard A van Hoof, Stephanie Zaaijer, Theo W Prins, Esther J Kok
In most countries, systems are in place to analyse food products for the potential presence of genetically modified organisms (GMOs), to enforce labelling requirements and to screen for the potential presence of unauthorised GMOs. With the growing number of GMOs on the world market, a larger diversity of methods is required for informative analyses. In this paper, the specificity of an extended screening set consisting of 32 screening methods to identify different crop species (endogenous genes) and GMO elements was verified against 59 different GMO reference materials...
June 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28414950/a-nanobiosensor-composed-of-exfoliated-graphene-oxide-and-gold-nano-urchins-for-detection-of-gmo-products
#19
Zahra Aghili, Navid Nasirizadeh, Adeleh Divsalar, Shahram Shoeibi, Parichehreh Yaghmaei
Genetically Modified Organisms, have been entered our food chain and detection of these organisms in market products are still the main challenge for scientists. Among several developed detection/quantification methods for detection of these organisms, the electrochemical nanobiosensors are the most attended which are combining the advantages of using nanomaterials, electrochemical methods and biosensors. In this research, a novel and sensitive electrochemical nanobiosensor for detection/quantification of these organisms have been developed using nanomaterials; Exfoliated Graphene Oxide and Gold Nano-Urchins for modification of the screen-printed carbon electrode, and also applying a specific DNA probe as well as hematoxylin for electrochemical indicator...
September 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28381773/a-novel-chemical-enhancer-approach-for-transdermal-drug-delivery-with-c17-monoglycerol-ester-liquid-crystal-forming-lipid
#20
COMPARATIVE STUDY
Wesam R Kadhum, Shohei Sekiguchi, Ichiro Hijikuro, Hiroaki Todo, Kenji Sugibayashi
Transdermal administration of drugs represents an excellent alternative to conventional pharmaceutical dosage forms. However, insufficient penetration of the active pharmaceutical substance through the skin is a common problem. Thus, in the present study we evaluated the skin permeation enhancing ability of liquid crystal (LC) topical formulations. A recently developed LC-forming lipid, C17- monoglycerol ester (MGE), was evaluated and compared with glycerol monoolate (GMO), which is considered as the gold standard for LC formulations...
May 1, 2017: Journal of Oleo Science
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