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Domoic acid

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https://www.readbyqxmd.com/read/28535464/occurrence-of-marine-algal-toxins-in-oyster-and-phytoplankton-samples-in-daya-bay-south-china-sea
#1
Tao Jiang, Lei Liu, Yang Li, Jing Zhang, Zhijun Tan, Haiyan Wu, Tianjiu Jiang, Songhui Lu
The occurrence and seasonal variations of marine algal toxins in phytoplankton and oyster samples in Daya Bay (DYB), South China Sea were investigated. Two Dinophysis species, namely, D. caudata and D. acuminata complex, were identified as Okadaic acid (OA)/pectenotoxin (PTX) related species. Liquid chromatography with tandem mass spectrometry (LC-MS/MS) analysis demonstrated that 2.04-14.47 pg PTX2 per cell was the predominant toxin in single-cell isolates of D. caudata. D. acuminata was not subjected to toxin analysis...
May 12, 2017: Chemosphere
https://www.readbyqxmd.com/read/28442131/multipoint-recognition-of-domoic-acid-from-seawater-by-dummy-template-molecularly-imprinted-solid-phase-extraction-coupled-with-high-performance-liquid-chromatography
#2
Xiuping He, Jianlei Chen, Jiangtao Wang, Liju Tan
Due to the high cost of domoic acid (DA), different carboxylic acid compounds including indole-3-acetic acid (IAA), pyrrole-2-formic acid (PFA), pyridine-2,3-dicarboxylic anhydride (PDA), trimesitinic acid (TA) and citric acid (CA) were investigated as dummy templates for the molecularly imprinted solid-phase extraction (MISPE) for selective isolation and pre-concentration of an amnesic shellfish poison (ASP), DA. The highest binding amount of the polymers towards DA was obtained when CA was used as dummy template owing to its high hydrophilicity...
April 13, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28427569/chronic-low-level-exposure-to-the-common-seafood-toxin-domoic-acid-causes-cognitive-deficits-in-mice
#3
Kathi A Lefebvre, Preston S Kendrick, Warren Ladiges, Emma M Hiolski, Bridget E Ferriss, Donald R Smith, David J Marcinek
The consumption of one meal of seafood containing domoic acid (DA) at levels high enough to induce seizures can cause gross histopathological lesions in hippocampal regions of the brain and permanent memory loss in humans and marine mammals. Seafood regulatory limits have been set at 20mgDA/kg shellfish to protect human consumers from symptomatic acute exposure, but the effects of repetitive low-level asymptomatic exposure remain a critical knowledge gap. Recreational and Tribal-subsistence shellfish harvesters are known to regularly consume low levels of DA...
April 2017: Harmful Algae
https://www.readbyqxmd.com/read/28427568/inter-and-intra-specific-growth-and-domoic-acid-production-in-relation-to-nutrient-ratios-and-concentrations-in-pseudo-nitzschia-phosphate-an-important-factor
#4
Kimberley A Lema, Marie Latimier, Élisabeth Nézan, Juliette Fauchot, Mickael Le Gac
The factors responsible for inducing the synthesis of toxins and responses from toxic phytoplankton blooms remain unclear. In this study we compare the influence of genotypic (at both the intra and interspecific levels) and environmental factors (nutrient concentration and ratio) on growth (in terms of cell densities) and domoic acid (DA) production in three Pseudo-nitzschia species: P. australis, P.pungens and P.fradulenta. A strong phosphate effect was detected. More precisely, a low initial concentration in phosphate, even at high initial nitrogen and silicate concentrations, induced the highest DA concentrations and the lowest cell densities in all strains/species studied...
April 2017: Harmful Algae
https://www.readbyqxmd.com/read/28366399/species-occurrence-of-the-potentially-toxigenic-diatom-genus-pseudo-nitzschia-and-the-associated-neurotoxin-domoic-acid-in-the-argentine-sea
#5
Gastón O Almandoz, Elena Fabro, Martha Ferrario, Urban Tillmann, Allan Cembella, Bernd Krock
The marine diatom genus Pseudo-nitzschia, the major known producer of the neurotoxin domoic acid (DA) responsible for the amnesic shellfish poisoning (ASP) syndrome in humans and marine mammals, is globally distributed. The genus presents high species richness in the Argentine Sea and DA has been frequently detected in the last few years in plankton and shellfish samples, but the species identity of the producers remains unclear. In the present work, the distribution and abundance of Pseudo-nitzschia species and DA were determined from samples collected on two oceanographic cruises carried out through the Argentine Sea (∼39-47°S) during summer and spring 2013...
March 2017: Harmful Algae
https://www.readbyqxmd.com/read/28366394/the-relationship-between-pseudo-nitzschia-peragallo-and-domoic-acid-in-scottish-shellfish
#6
E Bresnan, R J Fryer, S Fraser, N Smith, L Stobo, N Brown, E Turrell
The diatom genus Pseudo-nitzschia (Peragallo) associated with the production of domoic acid (DA), the toxin reposnsible for amnesic shellfish poisoning, is abundant in Scottish waters. A two year study examined the relationship between Pseudo-nitzschia cells in the water column and DA concentration in blue mussels (Mytilus edulis) at two sites, and king scallops (Pecten maximus) at one site. The rate of DA uptake and depuration differed greatly between the two species with M. edulis whole tissue accumulating and depurating 7μgg(-1) (now expressed as mgkg(-1)) per week...
March 2017: Harmful Algae
https://www.readbyqxmd.com/read/28342004/modulatory-effects-of-terminalia-arjuna-against-domoic-acid-induced-toxicity-in-caco-2-cell-line
#7
E M Ramya, G Phani Kumar, T Anand, K R Anilakumar
Domoic acid is a potent marine algal toxin produced by diatomic genus of Pseudo-nitzschia causing amnesic shell fish poisoning. Domoic acid toxicosis mainly involves excitotoxic effects coupled with oxidative stress. The present study was aimed to evaluate the protective effects of hydro-alcoholic extract of Terminalia arjuna (TA) against domoic acid induced toxic effects in Caco-2 cell line. It was observed that the toxicity induced by domoic acid in Caco-2 cells was mediated by oxidative insult leading to morphological changes, DNA damage and apoptosis...
March 24, 2017: Cytotechnology
https://www.readbyqxmd.com/read/28285260/microsatellite-markers-for-population-genetic-applications-in-the-domoic-acid-producing-diatom-pseudo-nitzschia-australis-frenguelli-bacillariophyceae
#8
Nicolaus G Adams, Piper Schwenke, G Jason Smith, Vera L Trainer
Microsatellites are commonly used markers in population genetics and are increasingly being employed to determine population structure in phytoplankton populations. We have developed seven polymorphic microsatellite markers for the domoic-acid producing diatom Pseudo-nitzschia australis. Using these markers, thirty P. australis isolates were genotyped, 10 isolates were from Monterey Bay, California and 20 were from off the northern coast of Oregon. The number of alleles per locus ranged from two to eight and observed heterozygosities ranged from 0...
January 26, 2017: Protist
https://www.readbyqxmd.com/read/28277184/quercetin-attenuates-domoic-acid-induced-cognitive-deficits-in-mice
#9
Dongmei Wang, Jianlong Zhao, Sanqiang Li, Guomin Shen, Shu Hu
Domoic acid (DA) is one of the best known marine toxins, causative of important neurotoxic alterations. DA effects are documented both in wildlife and experimental assays, showing that this toxin causes severe injuries principally in the hippocampal area. Accumulating evidence indicates that mitochondrial dysfunction and oxidative stress are involved in DA-induced cognitive functional impairment. Therefore, therapeutics targeted to improve mitochondrial function and increase oxidative stress defence could be beneficial...
September 26, 2016: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28208796/recent%C3%A2-trends%C3%A2-in%C3%A2-marine%C3%A2-phycotoxins%C3%A2-from%C3%A2-australian%C3%A2-coastal%C3%A2-waters
#10
Penelope Ajani, D Tim Harwood, Shauna A Murray
Phycotoxins, which are produced by harmful microalgae and bioaccumulate in the  marine food web, are of growing concern for Australia. These harmful algae pose a threat to  ecosystem and human health, as well as constraining the progress of aquaculture, one of the fastest  growing food sectors in the world. With better monitoring, advanced analytical skills and an  increase in microalgal expertise, many phycotoxins have been identified in Australian coastal  waters in recent years...
February 9, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28160435/fast-analysis-of-domoic-acid-using-microchip-electrophoresis-with-laser-induced-fluorescence-detection
#11
Yongqiang Cheng, Cuilian Guo, Bin Zhao, Li Yang
A fast and effective method was developed to detect domoic acid based upon microchip electrophoresis combined with laser-induced fluorescence detection. Through study of the gated injection process on the cross channel of the microchip, the low-voltage mode with relatively longer sample loading time was adopted to reduce the sample discrimination and improve the signal sensitivity. Fluorescein isothiocyanate was used as the derivatizing reagent for domoic acid. Under the optimized conditions, domoic acid was completely separated in 60 s with separation efficiency of 1...
February 4, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28109640/acute-and-chronic-dietary-exposure-to-domoic-acid-in-recreational-harvesters-a-survey-of-shellfish-consumption-behavior
#12
Bridget E Ferriss, David J Marcinek, Daniel Ayres, Jerry Borchert, Kathi A Lefebvre
Domoic acid (DA) is a neurotoxin that is naturally produced by phytoplankton and accumulates in seafood during harmful algal blooms. As the prevalence of DA increases in the marine environment, there is a critical need to identify seafood consumers at risk of DA poisoning. DA exposure was estimated in recreational razor clam (Siliqua patula) harvesters to determine if exposures above current regulatory guidelines occur and/or if harvesters are chronically exposed to low levels of DA. Human consumption rates of razor clams were determined by distributing 1523 surveys to recreational razor clam harvesters in spring 2015 and winter 2016, in Washington, USA...
April 2017: Environment International
https://www.readbyqxmd.com/read/28073557/diatom-nitzschia-navis-varingica-bacillariophyceae-and-its-domoic-acid-production-from-the-mangrove-environments-of-malaysia
#13
Suh Nih Tan, Sing Tung Teng, Hong Chang Lim, Yuichi Kotaki, Stephen S Bates, Chui Pin Leaw, Po Teen Lim
The distribution of the toxic pennate diatom Nitzschia was investigated at four mangrove areas along the coastal brackish waters of Peninsular Malaysia. Eighty-two strains of N. navis-varingica were isolated and established, and their identity confirmed morphologically and molecularly. Frustule morphological characteristics of the strains examined are identical to previously identified N. navis-varingica, but with a sightly higher density of the number of areolae per 1μm (4-7 areolae). Both LSU and ITS rDNAs phylogenetic trees clustered all strains in the N...
December 2016: Harmful Algae
https://www.readbyqxmd.com/read/28073545/a-validated-uplc-ms-ms-method-for-the-surveillance-of-ten-aquatic-biotoxins-in-european-brackish-and-freshwater-systems
#14
Brett Greer, Sara E McNamee, Bas Boots, Lucia Cimarelli, Delphine Guillebault, Karim Helmi, Stefania Marcheggiani, Stefan Panaiotov, Ulrich Breitenbach, Reyhan Akçaalan, Linda K Medlin, Katrin Kittler, Christopher T Elliott, Katrina Campbell
Over the past few decades, there has been an increased frequency and duration of cyanobacterial Harmful Algal Blooms (HABs) in freshwater systems globally. These can produce secondary metabolites called cyanotoxins, many of which are hepatotoxins, raising concerns about repeated exposure through ingestion of contaminated drinking water or food or through recreational activities such as bathing/swimming. An ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) multi-toxin method has been developed and validated for freshwater cyanotoxins; microcystins-LR, -YR, -RR, -LA, -LY and -LF, nodularin, cylindrospermopsin, anatoxin-a and the marine diatom toxin domoic acid...
May 2016: Harmful Algae
https://www.readbyqxmd.com/read/28073532/toxigenic-algae-and-associated-phycotoxins-in-two-coastal-embayments-in-the-ebro-delta-nw-mediterranean
#15
Julia A Busch, Karl B Andree, Jorge Diogène, Margarita Fernández-Tejedor, Kerstin Toebe, Uwe John, Bernd Krock, Urban Tillmann, Allan D Cembella
Harmful Algal Bloom (HAB) surveillance is complicated by high diversity of species and associated phycotoxins. Such species-level information on taxonomic affiliations and on cell abundance and toxin content is, however, crucial for effective monitoring, especially of aquaculture and fisheries areas. The aim addressed in this study was to determine putative HAB taxa and related phycotoxins in plankton from aquaculture sites in the Ebro Delta, NW Mediterranean. The comparative geographical distribution of potentially harmful plankton taxa was established by weekly field sampling throughout the water column during late spring-early summer over two years at key stations in Alfacs and Fangar embayments within the Ebro Delta...
May 2016: Harmful Algae
https://www.readbyqxmd.com/read/28073530/variation-in-the-abundance-of-pseudo-nitzschia-and-domoic-acid-with-surf-zone-type
#16
Alan L Shanks, Steven G Morgan, Jamie MacMahan, Ad J H M Reniers, Raphael Kudela, Marley Jarvis, Jenna Brown, Atsushi Fujimura, Lisa Ziccarelli, Chris Griesemer
Most harmful algal blooms (HAB) originate away from the shore and, for them to endanger human health, they must be first transported to shore after which they must enter the surf zone where they can be feed upon by filter feeders. The last step in this sequence, entrance into the surf zone, depends on surf zone hydrodynamics. During two 30-day periods, we sampled Pseudo-nitzschia and particulate domoic acid (pDA) in and offshore of a more dissipative surf zone at Sand City, California (2010) and sampled Pseudo-nitzschia in and out of reflective surf zones at a beach and rocky shores at Carmel River State Beach, California (2011)...
May 2016: Harmful Algae
https://www.readbyqxmd.com/read/28073526/prevalence-of-algal-toxins-in-alaskan-marine-mammals-foraging-in-a-changing-arctic-and-subarctic-environment
#17
Kathi A Lefebvre, Lori Quakenbush, Elizabeth Frame, Kathy Burek Huntington, Gay Sheffield, Raphaela Stimmelmayr, Anna Bryan, Preston Kendrick, Heather Ziel, Tracey Goldstein, Jonathan A Snyder, Tom Gelatt, Frances Gulland, Bobette Dickerson, Verena Gill
Current climate trends resulting in rapid declines in sea ice and increasing water temperatures are likely to expand the northern geographic range and duration of favorable conditions for harmful algal blooms (HABs), making algal toxins a growing concern in Alaskan marine food webs. Two of the most common HAB toxins along the west coast of North America are the neurotoxins domoic acid (DA) and saxitoxin (STX). Over the last 20 years, DA toxicosis has caused significant illness and mortality in marine mammals along the west coast of the USA, but has not been reported to impact marine mammals foraging in Alaskan waters...
May 2016: Harmful Algae
https://www.readbyqxmd.com/read/28073524/distribution-occurrence-and-biotoxin-composition-of-the-main-shellfish-toxin-producing-microalgae-within-european-waters-a-comparison-of-methods-of-analysis
#18
Sara E McNamee, Linda K Medlin, Jessica Kegel, Gary R McCoy, Robin Raine, Lucia Barra, Maria Valeria Ruggiero, Wiebe H C F Kooistra, Marina Montresor, Johannes Hagstrom, Eva Perez Blanco, Edna Graneli, Francisco Rodríguez, Laura Escalera, Beatriz Reguera, Simon Dittami, Bente Edvardsen, Joe Taylor, Jane M Lewis, Yolanda Pazos, Christopher T Elliott, Katrina Campbell
Harmful algal blooms (HABs) are a natural global phenomena emerging in severity and extent. Incidents have many economic, ecological and human health impacts. Monitoring and providing early warning of toxic HABs are critical for protecting public health. Current monitoring programmes include measuring the number of toxic phytoplankton cells in the water and biotoxin levels in shellfish tissue. As these efforts are demanding and labour intensive, methods which improve the efficiency are essential. This study compares the utilisation of a multitoxin surface plasmon resonance (multitoxin SPR) biosensor with enzyme-linked immunosorbent assay (ELISA) and analytical methods such as high performance liquid chromatography with fluorescence detection (HPLC-FLD) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) for toxic HAB monitoring efforts in Europe...
May 2016: Harmful Algae
https://www.readbyqxmd.com/read/28073500/initial-skill-assessment-of-the-california-harmful-algae-risk-mapping-c-harm-system
#19
Clarissa R Anderson, Raphael M Kudela, Mati Kahru, Yi Chao, Leslie K Rosenfeld, Frederick L Bahr, David M Anderson, Tenaya A Norris
Toxic algal events are an annual burden on aquaculture and coastal ecosystems of California. The threat of domoic acid (DA) toxicity to human and wildlife health is the dominant harmful algal bloom (HAB) concern for the region, leading to a strong focus on prediction and mitigation of these blooms and their toxic effects. This paper describes the initial development of the California Harmful Algae Risk Mapping (C-HARM) system that predicts the spatial likelihood of blooms and dangerous levels of DA using a unique blend of numerical models, ecological forecast models of the target group, Pseudo-nitzschia, and satellite ocean color imagery...
November 2016: Harmful Algae
https://www.readbyqxmd.com/read/28073449/harmful-algal-bloom-forecast-system-for-sw-ireland-part-ii-are-operational-oceanographic-models-useful-in-a-hab-warning-system
#20
Caroline Cusack, Tomasz Dabrowski, Kieran Lyons, Alan Berry, Guy Westbrook, Rafael Salas, Conor Duffy, Glenn Nolan, Joe Silke
This study investigated the application of a three-dimensional physical hydrodynamic model in a harmful algal bloom forecast system for Bantry Bay, southwest Ireland. Modelled oceanographic conditions were studied and used to help understand observed changes in the chemical and biological patterns from the national biotoxins and phytoplankton monitoring program. The study focused on two toxic events in 2013. An upwelling event was predicted by the model prior to the appearance and population increase of potentially toxic diatoms, Pseudo-nitzschia, and associated domoic acid in shellfish...
March 2016: Harmful Algae
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