keyword
https://read.qxmd.com/read/38537017/preheated-acid-associated-with-silane-and-electric-current-in-the-adhesion-of-the-resin-cement-to-ceramic
#21
JOURNAL ARTICLE
Gustavo Belmiro Casaburi, Marcos Henrique Ramos da Silva, Lourenço Correr-Sobrinho, Rafael Leonardo Xediek Consani
This study verified the effect of the combination of preheated hydrofluoric acid/silane/electric current in the adhesion of the resin cement to ceramic. IPS E.max Press ceramic discs embedded in PVC rigid tubes were divided into four groups associating preheated hydrofluoric acid and silane applied with electrical current (n=10): Ha+S (Heated acid + silane); Ha+S+Ec (Heated acid + silane + electrical current); A+S (Acid + silane) and A+S+Ec (Acid + silano + electrical current). Resin cement/ceramic samples were stored in water at 37°C for 24h...
2024: Brazilian Dental Journal
https://read.qxmd.com/read/38536995/in-office-dental-bleaching-in-adolescents-using-6-hydrogen-peroxide-with-and-without-gingival-barrier-a-randomized-double-blind-clinical-trial
#22
JOURNAL ARTICLE
Taynara de Souza Carneiro, Michael Willian Favoreto, João Pedro Ferreira Rodrigues, Elisama Sutil, Gabrielle Gomes Centenaro, Isabela de Matos de Freitas, Alessandra Reis, Laura Ceballos García, Alessandro Dourado Loguercio
BACKGROUND: At low concentrations used for in-office bleaching gels, such as 6% HP, gingival barrier continues to be performed. If we take into account that, in the at-home bleaching technique, no barrier is indicated, it seems that the use of a gingival barrier fails to make much sense when bleaching gel in low concentration is used for in-office bleaching. OBJECTIVE: This double-blind, split-mouth, randomized clinical trial evaluated the gingival irritation (GI) of in-office bleaching using 6% hydrogen peroxide (HP) with and without a gingival barrier in adolescents, as well as color change and the impact of oral condition on quality of life...
2024: Journal of Applied Oral Science: Revista FOB
https://read.qxmd.com/read/38536994/injectable-platelet-rich-fibrin-effect-on-laser-depigmented-gingiva-a-clinical-randomized-controlled-split-mouth-trial-with-histological-assessment
#23
JOURNAL ARTICLE
Suzan Seif Allah Ibrahim, Ibrahim Abu Mandil, Ola Mohamed Ezzatt
OBJECTIVE: To determine whether intra-mucosal injection of injectable platelet-rich fibrin (i-PRF) can promote healing after Diode Laser Gingival Depigmentation (DLGD). METHODOLOGY: A total of 20 arch sites of hyperpigmented gingiva of 10 patients underwent DLGD. For each patient, two arch sites were randomly assigned for either intra-mucosal injection of i-PRF (G1-i-PRF) (n=10 sites) or no treatment (G2-Control): (n=10 sites). Wound Healing Score (WHS), patient satisfaction, and Pigmentation Index (DOPI) were measured at 1 week and 1 and 3 months postoperatively...
2024: Journal of Applied Oral Science: Revista FOB
https://read.qxmd.com/read/38536989/gender-psychological-distress-and-subjective-well-being-two-years-after-the-onset-of-the-covid-19-pandemic-in-spain
#24
JOURNAL ARTICLE
M Pilar Matud, Amelia Díaz, Mª José Del Pino, Demelza Fortes, Ignacio Ibáñez
This study aimed to examine gender differences in distress and well-being two years after the onset of the COVID-19 pandemic, analyzing risk and protective factors for psychological distress and subjective well-being. It is a repeated cross-sectional study with a sample of 1,588 women (50%) and men (50%) from the general Spanish population aged 18-74 years who were assessed online by seven questionnaires and scales. Descriptive, variance, and hierarchical multiple regression analyses were performed. From February to April 2022, 57...
2024: Cadernos de Saúde Pública
https://read.qxmd.com/read/38536983/clinical-outcomes-before-and-after-videofluoroscopic-swallow-study-in-children-24-months-of-age-or-younger
#25
JOURNAL ARTICLE
Fabiola Luciane Barth, Deborah Salle Levy, Marisa Gasparin, Cláudia Schweiger, Denise Manica, Camila Dalbosco Gadenz, Paulo José Cauduro Maróstica
OBJECTIVE: To evaluate the combined impact of videofluoroscopic swallow study (VFSS) and therapeutic feeding and swallowing interventions on clinical outcomes in children with oropharyngeal dysphagia (OPD). METHODS: This was an uncontrolled longitudinal analytical study in which OPD patients were evaluated before and after VFSS. Children ≤ 24 months of age diagnosed with OPD in a clinical setting and undergoing VFSS for investigation and management of OPD were included in the study...
2024: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://read.qxmd.com/read/38536980/connective-tissue-disease-associated-interstitial-lung-disease
#26
JOURNAL ARTICLE
Karin Mueller Storrer, Carolina de Souza Müller, Maxwell Cássio de Albuquerque Pessoa, Carlos Alberto de Castro Pereira
Connective tissue disease-associated interstitial lung disease (CTD-ILD) represents a group of systemic autoimmune disorders characterized by immune-mediated organ dysfunction. Systemic sclerosis, rheumatoid arthritis, idiopathic inflammatory myositis, and Sjögren's syndrome are the most common CTDs that present with pulmonary involvement, as well as with interstitial pneumonia with autoimmune features. The frequency of CTD-ILD varies according to the type of CTD, but the overall incidence is 15%, causing an important impact on morbidity and mortality...
2024: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://read.qxmd.com/read/38536974/distribution-of-benthic-macroinvertebrate-communities-in-different-kind-of-inland-water-bodies-in-northeastern-algeria
#27
JOURNAL ARTICLE
M Gharbi, N Ziane, A Baaloudj, P De Los Ríos-Escalante, C Esse, S Chaib, M Houhamdi
Benthic macroinvertebrates are integral parts of inland waters, inhabiting a diversity of aquatic ecosystems where communities are spatially structured. Macroinvertebrates of some Mediterranean regions such as North Africa are still not well studied. Due this reason we proposed study the community structure in water bodies located in Northeastern Algeria. For this objective, we sampled 12 different kind of water bodies, two dams, three rivers, and seven streams during the period from October 2020 to September 2021...
2024: Brazilian Journal of Biology
https://read.qxmd.com/read/38536966/the-effect-of-boxwood-leaf-volatiles-on-conidial-germination-of-calonectria-pseudonaviculata-the-causal-agent-of-boxwood-blight
#28
JOURNAL ARTICLE
Mana Ohkura, Bryan R Beck, Carolyn F Scagel, Jerry E Weiland
The fungal pathogen Calonectria pseudonaviculata causes boxwood blight and is a significant threat to the boxwood industry as well as historic boxwood gardens. The pathogen produces conidia in sticky masses that are splash dispersed, which germinate and infect through stomata on the leaves or stems, causing leaf spots and stem lesions. Despite its ability to cause severe infections on boxwood plants, the pathogen often has a low germination rate on artificial media under lab conditions. To identify cues that stimulate germination, we explored whether host factors could induce high germination rates...
March 27, 2024: Phytopathology
https://read.qxmd.com/read/38536960/unveiling-the-molecular-characteristics-origins-and-formation-mechanism-of-reduced-nitrogen-organic-compounds-in-the-urban-atmosphere-of-shanghai-using-a-versatile-aerosol-concentration-enrichment-system
#29
JOURNAL ARTICLE
Munila Abudumutailifu, Xiaona Shang, Lina Wang, Miaomiao Zhang, Huihui Kang, Yunqian Chen, Ling Li, Ruiting Ju, Bo Li, Huiling Ouyang, Xu Tang, Chunlin Li, Lin Wang, Xinke Wang, Christian George, Yinon Rudich, Renhe Zhang, Jianmin Chen
Reduced nitrogen-containing organic compounds (NOCs) in aerosols play a crucial role in altering their light-absorption properties, thereby impacting regional haze and climate. Due to the low concentration levels of individual NOCs in the air, the utilization of accurate detection and quantification technologies becomes essential. For the first time, this study investigated the diurnal variation, chemical characteristics, and potential formation pathways of NOCs in urban ambient aerosols in Shanghai using a versatile aerosol concentration enrichment system (VACES) coupled with HPLC-Q-TOF-MS...
March 27, 2024: Environmental Science & Technology
https://read.qxmd.com/read/38536949/combination-nano-delivery-systems-remodel-the-immunosuppressive-tumor-microenvironment-for-metastatic-triple-negative-breast-cancer-therapy
#30
JOURNAL ARTICLE
Liya Bai, Hui Liu, Ran You, Xiaoyu Jiang, Tao Zhang, Yunan Li, Tianhe Shan, Zhanyin Qian, Yinsong Wang, Yuanyuan Liu, Chunyu Li
Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer for which effective therapies are lacking. Targeted remodeling of the immunosuppressive tumor microenvironment (TME) and activation of the body's immune system to fight tumors with well-designed nanoparticles have emerged as pivotal breakthroughs in tumor treatment. To simultaneously remodel the immunosuppressive TME and trigger immune responses, we designed two potential therapeutic nanodelivery systems to inhibit TNBC. First, the bromodomain-containing protein 4 (BRD4) inhibitor JQ1 and the cyclooxygenase-2 (COX-2) inhibitor celecoxib (CXB) were coloaded into chondroitin sulfate (CS) to obtain CS@JQ1/CXB nanoparticles (NPs)...
March 27, 2024: Molecular Pharmaceutics
https://read.qxmd.com/read/38536937/comparison-of-the-immunogenicity-and-protective-efficacy-of-acam2000-mva-and-vectored-subunit-vaccines-for-mpox-in-rhesus-macaques
#31
JOURNAL ARTICLE
Catherine Jacob-Dolan, Darren Ty, David Hope, Katherine McMahan, Jinyan Liu, Olivia C Powers, Catherine A Cotter, Michela Sciacca, Cindy Wu, Erica Borducchi, Emily Bouffard, Hannah Richter, Jason Velasco, Elyse Teow, Mona Boursiquot, Anthony Cook, Karen Feliciano, Jake Yalley-Ogunro, Michael S Seaman, Laurent Pessiant, Mark G Lewis, Hanne Andersen, Bernard Moss, Dan H Barouch
The 2022-2023 mpox outbreak triggered vaccination efforts using smallpox vaccines that were approved for mpox, including modified vaccinia Ankara (MVA; JYNNEOS), which is a safer alternative to live replicating vaccinia virus (ACAM2000). Here, we compare the immunogenicity and protective efficacy of JYNNEOS by the subcutaneous or intradermal routes, ACAM2000 by the percutaneous route, and subunit Ad35 vector-based L1R/B5R or L1R/B5R/A27L/A33R vaccines by the intramuscular route in rhesus macaques. All vaccines provided robust protection against high-dose intravenous mpox virus challenge with the current outbreak strain, with ACAM2000 providing near complete protection and JYNNEOS and Ad35 vaccines providing robust but incomplete protection...
March 27, 2024: Science Translational Medicine
https://read.qxmd.com/read/38536929/discovery-and-characterization-of-noncanonical-e2-conjugating-enzymes
#32
JOURNAL ARTICLE
Syed Arif Abdul Rehman, Chiara Cazzaniga, Elena Di Nisio, Odetta Antico, Axel Knebel, Clare Johnson, Alp T Şahin, Peter E G F Ibrahim, Frederic Lamoliatte, Rodolfo Negri, M K Miratul Muqit, Virginia De Cesare
E2-conjugating enzymes (E2s) play a central role in the enzymatic cascade that leads to the attachment of ubiquitin to a substrate. This process, termed ubiquitylation, is required to maintain cellular homeostasis and affects almost all cellular process. By interacting with multiple E3 ligases, E2s dictate the ubiquitylation landscape within the cell. Since its discovery, ubiquitylation has been regarded as a posttranslational modification that specifically targets lysine side chains (canonical ubiquitylation)...
March 29, 2024: Science Advances
https://read.qxmd.com/read/38536924/different-components-of-cognitive-behavioral-therapy-affect-specific-cognitive-mechanisms
#33
JOURNAL ARTICLE
Agnes Norbury, Tobias U Hauser, Stephen M Fleming, Raymond J Dolan, Quentin J M Huys
Psychological therapies are among the most effective treatments for common mental health problems-however, we still know relatively little about how exactly they improve symptoms. Here, we demonstrate the power of combining theory with computational methods to parse effects of different components of cognitive-behavioral therapies onto underlying mechanisms. Specifically, we present data from a series of randomized-controlled experiments testing the effects of brief components of behavioral and cognitive therapies on different cognitive processes, using well-validated behavioral measures and associated computational models...
March 29, 2024: Science Advances
https://read.qxmd.com/read/38536890/experts-views-on-translating-nhs-support-to-stop-smoking-in-pregnancy-into-a-comprehensive-digital-intervention
#34
JOURNAL ARTICLE
Lisa McDaid, Pippa Belderson, Joanne Emery, Tim Coleman, Jo Leonardi-Bee, Felix Naughton
Many pregnant smokers need support to quit successfully. In the United Kingdom, trained smoking cessation advisors deliver structured behavioural counselling alongside access to free nicotine replacement therapy (NRT); known as the 'Standard Treatment Programme' (STP). Pregnant smokers who access STP support are more likely to quit, but uptake is low. A digital intervention could be offered as an adjunct or alternative to existing STP support to increase cessation rates. However, there are few pregnancy-specific digital options routinely available and, among those that are, there is limited evidence of their effectiveness...
March 2024: PLOS Digit Health
https://read.qxmd.com/read/38536888/barriers-and-benefits-of-online-group-exercise-programs-for-older-adults
#35
JOURNAL ARTICLE
Md Shafiqul Islam, Mary C Frazier, Samantha M Harden, Sol Lim
Engaging in regular physical activity offers a myriad of benefits, including the improvement of mental health, social well-being, and cognitive function. Unfortunately, obstacles, such as transportation constraints, time limitations, and inadequate exercise facilities, hinder the regular participation of older adults in physical activity. Online group physical activity programs present a promising solution to enhance the involvement of older adults; however, several barriers impede their effective utilization...
March 27, 2024: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
https://read.qxmd.com/read/38536880/bias-in-the-arrival-of-variation-can-dominate-over-natural-selection-in-richard-dawkins-s-biomorphs
#36
JOURNAL ARTICLE
Nora S Martin, Chico Q Camargo, Ard A Louis
Biomorphs, Richard Dawkins's iconic model of morphological evolution, are traditionally used to demonstrate the power of natural selection to generate biological order from random mutations. Here we show that biomorphs can also be used to illustrate how developmental bias shapes adaptive evolutionary outcomes. In particular, we find that biomorphs exhibit phenotype bias, a type of developmental bias where certain phenotypes can be many orders of magnitude more likely than others to appear through random mutations...
March 2024: PLoS Computational Biology
https://read.qxmd.com/read/38536877/comparative-study-on-differential-expression-analysis-methods-for-single-cell-rna-sequencing-data-with-small-biological-replicates-based-on-single-cell-transcriptional-data-of-pbmcs-from-covid-19-severe-patients
#37
JOURNAL ARTICLE
Jie Xue, Xinfan Zhou, Jing Yang, Adan Niu
Single-cell RNA sequencing (scRNA-seq) is a high-throughput experimental technique for studying gene expression at the single-cell level. As a key component of single-cell data analysis, differential expression analysis (DEA) serves as the foundation for all subsequent secondary studies. Despite the fact that biological replicates are of vital importance in DEA process, small biological replication is still common in sequencing experiment now, which may impose problems to current DEA methods. Therefore, it is necessary to conduct a thorough comparison of various DEA approaches under small biological replications...
2024: PloS One
https://read.qxmd.com/read/38536869/study-protocol-identifying-transcriptional-regulatory-alterations-of-chronic-effects-of-blast-and-disturbed-sleep-in-united-states-veterans
#38
JOURNAL ARTICLE
Molly J Sullan, Kelly A Stearns-Yoder, Zhaoyu Wang, Andrew J Hoisington, Adam D Bramoweth, Walter Carr, Yongchao Ge, Hanga Galfalvy, Fatemah Haghighi, Lisa A Brenner
Injury related to blast exposure dramatically rose during post-911 era military conflicts in Iraq and Afghanistan. Mild traumatic brain injury (mTBI) is among the most common injuries following blast, an exposure that may not result in a definitive physiologic marker (e.g., loss of consciousness). Recent research suggests that exposure to low level blasts and, more specifically repetitive blast exposure (RBE), which may be subconcussive in nature, may also impact long term physiologic and psychological outcomes, though findings have been mixed...
2024: PloS One
https://read.qxmd.com/read/38536868/the-social-determinants-of-migrant-domestic-worker-mdw-health-and-well-being-in-the-western-pacific-region-a-scoping-review
#39
JOURNAL ARTICLE
Jamie Chan, Georgia Dominguez, Antonia Hua, Melissa Garabiles, Carl A Latkin, Brian J Hall
The health and well-being of transnational migrant domestic workers (MDWs) is a pressing but largely neglected public health concern. The Asia Pacific region is home to over 20% of the global MDW population. Living and working conditions, social contexts, political environments, and migration regimes are recognized as consequential to the health of this population, but currently no synthesis of available literature to prioritize research or policy agenda setting for MDW has yet been conducted. This scoping review screened 6,006 peer-reviewed articles and 1,217 gray literature sources, identifying 173 articles and 276 gray literature sources that reported key MDW health outcomes, social determinants of health, and related interventions...
2024: PLOS Glob Public Health
https://read.qxmd.com/read/38536867/evaluating-spatially-enabled-machine-learning-approaches-to-depth-to-bedrock-mapping-alberta-canada
#40
JOURNAL ARTICLE
Steven M Pawley, Lisa Atkinson, Daniel J Utting, Gregory M D Hartman, Nigel Atkinson
Maps showing the thickness of sediments above the bedrock (depth to bedrock, or DTB) are important for many geoscience studies and are necessary for many hydrogeological, engineering, mining, and forestry applications. However, it can be difficult to accurately estimate DTB in areas with varied topography, like lowland and mountainous terrain, because traditional methods of predicting bedrock elevation often underestimate or overestimate the elevation in rugged or incised terrain. Here, we describe a machine learning spatial prediction approach that uses information from traditional digital elevation model derived estimates of terrain morphometry and satellite imagery, augmented with spatial feature engineering techniques to predict DTB across Alberta, Canada...
2024: PloS One
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