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A Messerschmidt-Roth, W Sekundo, A Lazaridis, S Schulze
Background: The aim of this clinical trial was to check the results of laser built-in settings 3 years after ReLEx SMILE for moderate and high myopia in unselected "real life" patients. Patients and Methods: 50 myopic eyes of 27 patients were called in for examination after 3 years. 25 of these eyes with a preoperative myopia under - 6D comprised the "moderate myopia subgroup". All surgeries were performed with the 500 kHz VisuMax® femtosecond laser (Carl Zeiss Meditec AG, Jena) in the "fast mode" setting...
December 9, 2016: Klinische Monatsblätter Für Augenheilkunde
Linda L H Russell, Elizabeth I Johnson
Excessive gaming among emerging adults is a growing concern, especially in cases where it interferes with key developmental milestones such as gaining an education or establishing a career. Although researchers have begun to understand the effects of excessive gaming on young people themselves, we know remarkably little about how emerging adults' gaming may affect family relationships. Utilizing phenomenological interviewing of parents of emerging adult sons who game excessively, this study presents a rich description of the experience of parenting a young adult who games excessively...
December 9, 2016: Issues in Mental Health Nursing
Verónica G Vegas, Romina Lorca, Ana Latorre, Khaled Hassanein, Carlos J Gómez-García, Oscar Castillo, Álvaro Somoza, Félix Zamora, Pilar Amo-Ochoa
The direct reaction between copper nitrate, thymine-1-acetic acid, and 4,4'-bipyridine in water leads to the formation of a blue colloid comprising uniform crystalline nanoribbons (length >1 μm; width ca. 150-185 nm; diameter ca. 15-60 nm) of a coordination polymer. The polymer displays a thymine-based structure freely available for supramolecular interactions. These nanostructures show significant selective interaction with single-stranded oligonucleotides based on adenine. Remarkably, they present low cell toxicity in three cell lines-despite the copper(II) content-and can be used as nanocarriers of oligonucleotides...
December 9, 2016: Angewandte Chemie
Wenpei Fan, Nan Lu, Peng Huang, Yi Liu, Zhen Yang, Sheng Wang, Guocan Yu, Yijing Liu, Junkai Hu, Qianjun He, Junle Qu, Tianfu Wang, Xiaoyuan Chen
Glucose is a key energy supplier and nutrient for tumor growth. Herein, inspired by the glucose oxidase (GOx)-assisted conversion of glucose into gluconic acid and toxic H2 O2 , a novel treatment paradigm of starving-like therapy is developed for significant tumor-killing effects, more effective than conventional starving therapy by only cutting off the energy supply. Furthermore, the generated acidic H2 O2 can oxidize l-Arginine (l-Arg) into NO for enhanced gas therapy. By using hollow mesoporous organosilica nanoparticle (HMON) as a biocompatible/biodegradable nanocarrier for the co-delivery of GOx and l-Arg, a novel glucose-responsive nanomedicine (l-Arg-HMON-GOx) has been for the first time constructed for synergistic cancer starving-like/gas therapy without the need of external excitation, which yields a remarkable H2 O2 -NO cooperative anticancer effect with minimal adverse effect...
December 9, 2016: Angewandte Chemie
Zi-Shuo Yao, Shu-Qi Wu, Yasutaka Kitagawa, Sheng-Qun Su, You-Gui Huang, Guo-Ling Li, Zhong-Hai Ni, Hiroyuki Nojiri, Yoshihito Shiota, Kazunari Yoshizawa, Soonchul Kang, Shinji Kanegawa, Osamu Sato
Atypically anisotropic and large changes in magnetic susceptibility, along with a change in crystalline shape, were observed in a Co(II) complex at near room temperature. This was achieved by combining oxalate molecules, acting as rotor, and a Co(II) ion with unquenched orbital angular momentum. A thermally controlled 90° rotation of the oxalate counter anion triggered a symmetry-breaking ferroelastic phase transition, accompanied by contraction-expansion behavior (ca. 4.5 %) along the long axis of a rod-like single crystal...
December 9, 2016: Angewandte Chemie
Lays Magalhães Braga, Gustavo Faibischew Prado, Iracema Ioco Kikuchi Umeda, Tatiana Satie Kawauchi, Adriana Marques Fróes Taboada, Raymundo Soares Azevedo, Horacio Gomes Pereira Filho, César José Grupi, Hayala Cristina Cavenague Souza, Dalmo Antônio Ribeiro Moreira, Naomi Kondo Nakagawa
Heart rate variability (HRV) analysis is a useful method to assess abnormal functioning in the autonomic nervous system and to predict cardiac events in patients with heart failure (HF). HRV measurements with heart rate monitors have been validated with an electrocardiograph in healthy subjects but not in patients with HF. We explored the reproducibility of HRV in two consecutive six-minute walk tests (6MW), 60-minute apart, using a heart rate monitor (PolarS810i) and a portable electrocardiograph (called Holter) in 50 HF patients (mean age 59 years, NYHA II, left ventricular ejection fraction ~35%)...
2016: PloS One
Guolong Tan, Yao Huang, Haohao Sheng
We report here realization of ferroelectricity, ferromagnetism and magnetocapacitance effect in singleSrFe12O19ceramic at room temperature. The ceramics demonstrate a saturated polarization hysteresis loop, two nonlinear I-V peaks and large anomaly of dielectric constant near Curie temperature, which confirm the intrinsic ferroelectricity of SrFe12O19 ceramicswith subsequent heat-treatment in O2atmosphere. The remnant polarization of the SrFe12O19 ceramic is estimated to be 103μC/cm2. The ceramic also exhibits strong ferromagnetic characterization, the coercive field and remnant magnetic moment are 6192Oe and 35...
2016: PloS One
Jing Hu, Manman Zhu, Kehai Liu, Hua Fan, Wenfang Zhao, Yuan Mao, Yaguang Zhang
Lack of capacity to cross the nucleus membrane seems to be one of the main reasons for the lower transfection efficiency of gene vectors observed in vivo study than in vitro. To solve this problem, a new non-viral gene vector was designed. First, a degradable polyethylenimine (PEI) derivate was synthesized by crosslinking low-molecular-weight (LMW) PEI with N-octyl-N-quaternary chitosan (OTMCS), and then adopting a designed trifunctional peptide (RGDC-TAT-NLS) with good tumor targeting, cell uptake and nucleus transport capabilities to modify OTMCS-PEI...
2016: PloS One
Feng-Che Kuan, Shih-Hong Li, Chih-Liang Wang, Meng-Hung Lin, Ying-Huang Tsai, Cheng-Ta Yang
BACKGROUND: Gefitinib, erlotinib and afatinib provide remarkable response rates and progression-free survival compared to platinum-based chemotherapy in patients with non-small cell lung cancer harboring epidermal growth factor receptor-activating mutations, and are therefore standard first-line treatment in these patients. However, no study has compared these drugs regarding progression-free survival. MATERIALS AND METHODS: We conducted this retrospective study at a single medical center in Taiwan from February 16, 2011 to October 30, 2015...
December 7, 2016: Oncotarget
Junwei Liu, Hua Wang, Chen Fang, Liang Fu, Xiaofeng Qian
Novel materials with nontrivial electronic and photonic band topology are crucial for realizing novel devices with low power consumption and heat dissipation and quantum computing free of decoherence. Here, we theoretically predict a novel class of ternary transition metal chalcogenides that exhibit dual topological characteristics, quantum spin Hall insulators (QSHIs) in their two-dimensional (2D) monolayers and topological Weyl semimetals in their 3D noncentrosymmetric crystals upon van der Waals (vdW) stacking...
December 9, 2016: Nano Letters
Juan I Blanco Capurro, Chad W Hopkins, Gustavo Pierdominici-Sottile, Mariano Camilo Gonzalez Lebrero, Adrian E Roitberg, Marcelo A Marti
Understanding enzymatic reactions with atomic resolution has proven in recent years to be of tremendous interest for biochemical research, and thus the use of QM/MM dynamic methods for the study of reaction mechanisms is experiencing a continuous growth. Glycosyltransferases (GTs) catalyze the formation of glycosidic bonds, and are important for many biotechnological purposes, including drug targeting. Their reaction may proceed with one of two possible stereochemical outcomes for the reacting anomeric center and, therefore, they are classified as either inverting or retaining GTs...
December 9, 2016: Journal of Physical Chemistry. B
Patrick Drücker, Andreas Rühling, David Grill, Da Wang, Annette Draeger, Volker Gerke, Frank Glorius, Hans-Joachim Galla
Tailor-made ionic liquids based on imidazolium salts have recently attracted a large amount of attention because of their extraordinary properties and versatile functionality. An intriguing ability to interact with and stabilize membranes has already been reported for 1,3-dialkylimidazolium compounds. We now reveal further insights into the field by investigating 1,3-dimethyl-4,5-dialkylimidazolium (Cn-IMe·HI, n = 7, 11, 15) and 1,3-dibenzyl-4,5-dialkylimidazolium (Cn-IBn·HBr, n = 7, 11, 15) salts. Diverse alkyl chain lengths and headgroups differing in their steric demand were employed for the membrane interface interaction with bilayer membranes imitating the cellular plasma membrane...
December 9, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
Haixia Zhao, Jing Liu, Laixin Song, Zhencai Liu, Guifang Han, Ding Yuan, Ting Wang, Yaoyan Dun, Zhiyong Zhou, Zhaoqi Liu, Yongjun Wang, Changcheng Zhang
OBJECTIVES: Inflammation can cause degenerative changes of reproductive function. Oleanolic acid (OA), the effective component from Ligustrum lucidum Ait., exhibits significantly anti-inflammation and antiageing activity. However, whether OA restores testicular dysfunction via inhibition of inflammation with ageing is unclear. Here, in a natural ageing rat model, we investigated the protection effects of OA and its mechanism of action. METHODS: Eighteen-month-old Sprague Dawley (SD) rats were randomly divided into ageing control group and two OA-treated groups (5 and 25 mg/kg)...
December 9, 2016: Journal of Pharmacy and Pharmacology
Agnes Arnold-Forster
Despite its prominent position in today's medical research, popular culture and everyday life, cancer's history is relatively unwritten. Compared to the other great 'plagues' - cholera, tuberculosis or tropical fevers, to name but a scant handful - cancer has few dedicated pages in the general surveys, and its specialists have largely failed to convince the broader community of medical historians - or indeed historians of anything at all - that histories of the disease can tell us fundamental things about the science and practice of medicine, both past and present...
December 2016: British Journal for the History of Science
Ruochen Fang, Huacheng Zhang, Liulin Yang, Huanting Wang, Ye Tian, Xi Zhang, Lei Jiang
Artificial nanochannels, inheriting smart gating functions of biological ion channels, promote the development of artificial functional nanofluidic devices for high-performance biosensing and electricity generation. However, gating states of the artificial nanochannels have been mainly realized through chemical modification of the channels with responsive molecules, and their gating states cannot be further regulated once the nanochannel is modified. In this work, we employed a new supramolecular layer-by-layer (LbL) self-assembly method to achieve reversible and adjustable multiple gating features in nanofluidic diodes...
December 9, 2016: Journal of the American Chemical Society
Guofeng Li, Kecheng Quan, Yuping Liang, Tianyi Li, Qipeng Yuan, Lei Tao, Qian Xie, Xing Wang
Montmorillonite (MMT) is considered to be the most effective hemostat among natural phyllosilicates. However, there is a barrier against using MMT for the commercial hemostatics because the invaded MMT powders might cause thrombosis in vessel. Till now, it is still a challenge to manage the release of MMT and eliminate its side effect. Herein, we present a graphene-MMT composite sponge (GMCS), synthesized under a hydrothermal reaction, fixing MMT powders into the cross-linked graphene sheets. We demonstrate that only a few embedded MMT can evoke remarkable platelet stimulation at the sponge interface, while maintaining fast plasma absorbency of the innate sponge...
December 9, 2016: ACS Applied Materials & Interfaces
Purnima S Kompella, Alan M Moses, Sergio G Peisajovich
The cellular concentrations of key components of signaling networks are tightly regulated, as deviations from their optimal ranges can have negative effects on signaling function. For example, overexpression of the yeast mating pathway mitogen-activated protein kinase (MAPK) Fus3 decreases pathway output, in part by sequestering individual components away from functional multi-protein complexes. Using a synthetic biology approach, we investigated potential mechanisms by which selection could compensate for a decrease in signaling activity caused by overexpression of Fus3...
December 9, 2016: ACS Synthetic Biology
Dong Cao, Jitao Lv, Fanglan Geng, Ziyu Rao, Hongyun Niu, Yali Shi, Yaqi Cai, Yuehui Kang
Natural organic matter (NOM) is a complex organic mixture and plays a crucial role in environmental processes. By using Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS), detailed molecular information on NOM could be achieved. In this paper, ion accumulation time (IAT), a key parameter of FTICR-MS for complex mixture detection, was the focus, and its effect on the molecular characterization of NOM by FTICR-MS was systematically investigated. A notable feature of selective detection of NOM molecules by FTICR-MS with different IAT was observed...
December 9, 2016: Analytical Chemistry
Sung Ho Jung, Ka Young Kim, Ji Ha Lee, Cheol Joo Moon, Noh Soo Han, Su-Jin Park, Dongmin Kang, Jae Kyu Song, Shim Sung Lee, Myong Yong Choi, Justyn Jaworski, Jong Hwa Jung
To more accurately assess the pathways of biological systems, a probe is needed that may respond selectively to adenosine triphosphate (ATP) for both in vitro and in vivo detection modes. We have developed a luminescence probe that can provide real-time information on the extent of ATP, ADP, and AMP by virtue of the luminescence and luminescence lifetime observed from a supramolecular polymer based on a C3 symmetrical terpyridine complex with Tb3+ (S1-Tb). The probe shows remarkable selective luminescence enhancement in the presence of ATP compared to other phosphate displaying nucleotides including adenosine diphosphate (ADP), adenosine monophosphate (AMP), guanosine triphosphate (GTP), thymidine triphosphate (TTP), H2PO4- (Pi), and pyrophosphate (PPi)...
December 9, 2016: ACS Applied Materials & Interfaces
Simonetta Fornarini, Davide Corinti, Alberto De Petris, Cecilia Coletti, Nazzareno Re, Barbara Chiavarino, Maria Elisa Crestoni
The primary complex obtained from cisplatin and L-histidine in water has been detected and isolated by electrospray ionization. The so-obtained cis-[PtCl(NH3)2(histidine)]+ complex has been thoroughly characterized by high resolution mass spectrometry (MS), tandem MS, IR multiple photon dissociation (IRMPD) spectroscopy and quantum chemical calculations. The structural features revealed by IRMPD spectroscopy indicate that platinum binds to the imidazole group, which presents tautomeric forms. Thus, depending on the position of the amino acid pendant on the imidazole ring, isomeric complexes are formed that are remarkably different in their ease to undergo fragmentation, when activated either by energetic collisions or by multiple IR photon absorption...
December 9, 2016: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
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