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Markus O Scheinhardt, Tamara Lerman, Inke R König, Georg Griesinger
STUDY QUESTION: What is the performance of previously established regression models in predicting low and high ovarian response to 150 μg corifollitropin alfa/GnRH-antagonist ovarian stimulation in an independent dataset? SUMMARY ANSWER: The outcome of ovarian stimulation with 150 μg corifollitropin alfa in a fixed, multiple dose GnRH-antagonist protocol can be validly predicted using logistic regression models with AMH being of paramount importance. WHAT IS KNOWN ALREADY: Predictors of ovarian response have been identified in FSH/GnRH agonist protocols as well as ovarian stimulation with corifollitropin alfa/GnRH-antagonist...
July 10, 2018: Human Reproduction
Katharina Dorn, Sabine Weinert, Terje Falck-Ytter
Investigating infants' ability to match visual and auditory speech segments presented sequentially allows us to understand more about the type of information they encode in each domain, as well as their ability to relate the information. One previous study found that 4.5- month-old infants' preference for visual French or German speech depended on whether they had previously heard the respective language, suggesting a remarkable ability to encode and relate audio-visual speech cues and to use these to guide their looking behavior...
July 11, 2018: Infant Behavior & Development
Wenbing Tan, Hanxia Yu, Caihong Huang, Dan Li, Hui Zhang, Xinyu Zhao, Renfei Li, Guoan Wang, Yuan Zhang, Xiaosong He, Beidou Xi
Whether crop intercropping can affect the uptake of phthalic acid esters (PAEs) by plant roots from soils is unclear. In this study, we compare the PAE uptake by plant roots between the wheat/maize intercropping and the wheat and maize monocropping in a field work. We show that the PAE bioconcentration factors of wheat and maize roots are remarkably higher under wheat/maize intercropping than under monocropping, indicating that intercropping may significantly increase the biouptake of PAEs as compared to monocropping...
July 6, 2018: Journal of Hazardous Materials
Ozren Stojanović, Silas Kieser, Mirko Trajkovski
Adipose tissues play an essential role in regulating the metabolic homeostasis and can be found in almost all parts of the body. Excessive adiposity leads to obesity and can contribute to metabolic and other disorders. Adipocytes show remarkable plasticity in their function, which can be pushed toward energy storage, or energy expenditure-a `browning' of fat. Browning is controlled by the cellular milieu of the adipose tissue, with sympathetic innervation and by immune responses as key integrators of the signals that promote browning...
July 11, 2018: Current Opinion in Cell Biology
Soyeong Sim, Sandra L Wolin
Y RNAs are noncoding RNAs (ncRNAs) that are present in most animal cells and also in many bacteria. These RNAs were discovered because they are bound by the Ro60 protein, a major target of autoantibodies in patients with some systemic autoimmune rheumatic diseases. Studies of Ro60 and Y RNAs in Deinococcus radiodurans , the first sequenced bacterium with a Ro60 ortholog, revealed that they function with 3'-to-5' exoribonucleases to alter the composition of RNA populations during some forms of environmental stress...
July 2018: Microbiology Spectrum
G Leuschner, C Neurohr
BACKGROUND: Pulmonary involvement in patients with underlying autoimmune diseases poses a major diagnostic and therapeutic challenge to the treating physician. Due to the associated increased mortality risk, early diagnosis is crucial. OBJECTIVE: The incidence and mortality rate of connective tissue disease-related interstitial lung diseases (CTD-ILD) and pulmonary hypertension (PH) were evaluated in patients with rheumatic disease including clinical aspects, diagnostic procedure, prognosis and treatment recommendations...
July 13, 2018: Zeitschrift Für Rheumatologie
Mohamed E Abd El-Hack, Sameh A Abdelnour, Ayman A Swelum, Muhammad Arif
In the past few decades, enhancement of animal productivity has been gaining increasing attention among decisions-makers, politicians, mangers, and breeders, because of the increasing of world population and shortage of natural resources. The selection of high productivity animals is the main goal, through the application of genetic improvement programs. The use of molecular genetics has conferred significant breeding advantages over conventional breeding techniques. In this regard, many economic characteristics are controlled by a small number of multiple gene loci, each of which is responsible for trait diversity and hence they are referred to as quantitative trait loci (QTL)...
July 13, 2018: Molecular Biology Reports
Hildegard Kehrer-Sawatzki, Lan Kluwe, Reinhard E Friedrich, Anna Summerer, Eleonora Schäfer, Ute Wahlländer, Cordula Matthies, Isabel Gugel, Said Farschtschi, Christian Hagel, David N Cooper, Victor-Felix Mautner
Schwannomatosis and neurofibromatosis type 2 (NF2) are both characterized by the development of multiple schwannomas but represent different genetic entities. Whereas NF2 is caused by mutations of the NF2 gene, schwannomatosis is associated with germline mutations of SMARCB1 or LZTR1. Here, we studied 15 sporadic patients with multiple non-intradermal schwannomas, but lacking vestibular schwannomas and ophthalmological abnormalities, who fulfilled the clinical diagnostic criteria for schwannomatosis. None of them harboured germline NF2 or SMARCB1 mutations as determined by the analysis of blood samples but seven had germline LZTR1 variants predicted to be pathogenic...
July 13, 2018: Human Genetics
Graham Heinson, Yohannes Didana, Paul Soeffky, Stephan Thiel, Tom Wise
World-class magmatic mineral systems are characterised by fluid/melt originating in the deep crust and mantle. However, processes that entrain and focus fluids from a deep-source region to a kilometre-scale deposit through the crust are unclear. A magnetotelluric (MT) and reflection seismic program across the margin of the Gawler Craton, Australia yield a distinct signature for a 1590 Ma event associated with emplacement of iron-oxide copper gold uranium (IOCG-U) deposits. Two- and three-dimensional MT modelling images a 50 km wide lower-crustal region of resistivity <10 Ωm along an accreted Proterozoic belt...
July 13, 2018: Scientific Reports
Yuanzheng Chen, Xinyong Cai, Hongyan Wang, Hongbo Wang, Hui Wang
Various nitrogen species in nitrides are fascinating since they often appear with these nitride as superconductors, hard materials, and high-energy density. As a typical complex, though iron nitride has been intensively studied, nitrogen species in the iron-nitrogen (Fe-N) compounds only have been confined to single atom (N) or molecule nitrogen (N2 ). Using a structure search method based on the CALYPSO methodology, unexpectedly, we here revealed two new stable high pressure (HP) states at 1:2 and 1:4 compositions with striking nitrogen species...
July 13, 2018: Scientific Reports
Pavlina Tsoka, Hidetaka Matsumoto, Daniel E Maidana, Keiko Kataoka, Irene Naoumidi, Achille Gravanis, Demetrios G Vavvas, Miltiadis K Tsilimbaris
Retinal detachment (RD) leads to photoreceptor cell death secondary to the physical separation of the retina from the underlying retinal pigment epithelium. Intensifying photoreceptor survival in the detached retina could be remarkably favorable for many retinopathies in which RD can be seen. BNN27, a blood-brain barrier (BBB)-permeable, C17-spiroepoxy derivative of dehydroepiandrosterone (DHEA) has shown promising neuroprotective activity through interaction with nerve growth factor receptors, TrkA and p75NTR ...
July 13, 2018: Scientific Reports
Lingjun Zhang, Mia Sorensen, Bjarne W Kristensen, Guido Reifenberger, Thomas M McIntyre, Feng Lin
PURPOSE: Somatic mutations in the isocitrate dehydrogenase (IDH)-1 and -2 genes are remarkably penetrant in diffuse gliomas. These highly effective gain-of-function mutations enable mutant IDH to efficiently metabolize isocitrate to D-2-hydroxyglutarate (D 2-HG) that accumulates to high concentrations within the tumor microenvironment. D 2-HG is an intracellular effector that promotes tumor growth through widespread epigenetic changes in IDH mutant tumor cells, but its potential role as an intercellular immune regulator remains understudied...
July 13, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Victoria L Nelson, Hoang C B Nguyen, Juan C Garcìa-Cañaveras, Erika R Briggs, Wesley Y Ho, Joanna R DiSpirito, Jill M Marinis, David A Hill, Mitchell A Lazar
The nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) is known to regulate lipid metabolism in many tissues, including macrophages. Here we report that peritoneal macrophage respiration is enhanced by rosiglitazone, an activating PPARγ ligand, in a PPARγ-dependent manner. Moreover, PPARγ is required for macrophage respiration even in the absence of exogenous ligand. Unexpectedly, the absence of PPARγ dramatically affects the oxidation of glutamine. Both glutamine and PPARγ have been implicated in alternative activation (AA) of macrophages, and PPARγ was required for interleukin 4 (IL4)-dependent gene expression and stimulation of macrophage respiration...
July 13, 2018: Genes & Development
Nicolas Broguiere, Florian Formica, Gonçalo Barreto, Marcy Zenobi-Wong
The bacterial ligase Sortase A (SA) and its mutated variants have become increasingly popular over the last years for post-translational protein modifications due to their unparalleled specificity and efficiency. The aim of this work was to study SA as a cross-linking enzyme for hydrogel-based tissue engineering. For this, we optimized SA pentamutant production and purification from E. coli to achieve high yields and purity. Then using hyaluronan (HA) as a model biopolymer and modifying it with SA-substrate peptides, we studied the cross-linking kinetics obtained with SA, the enzyme stability, cytocompatibility, and immunogenicity, and compared those to state-of-the-art standards...
July 10, 2018: Acta Biomaterialia
Priyanka Soni, Md Sajid Ghufran, Santosh R Kanade
The compulsive and insidious secondary metabolite aflatoxin B1 , produced by the opportunistic fungi Aspergillus flavus, upholds a distinguished place in midst of the toxicants causing fatal hazards to humans. Aflatoxins alter the function of host cells by inducing multiple effects through genetic and non-genetic pathways. Epigenetic mechanisms drag major attention towards finding novel and new mechanisms involved in this process. Our present work intends to study the functional expression profile of multiple epigenetic regulators...
July 10, 2018: Toxicon: Official Journal of the International Society on Toxinology
Carlos Eduardo Serrano-Maldonado, Maricarmen Quirasco
The genus Enterococcus occurs as native microbiota of fermented products due to its broad environmental distribution and its resistance to salt concentrations. Enterococcus faecalis F, a non-pathogenic strain isolated from a ripened cheese, has demonstrated useful enzymatic capabilities, a probiotic behavior and antibacterial activity against some food-borne pathogens, mainly due to peptidoglycan hydrolase activity. Its use as a natural pathogen-control agent could be further enhanced through the production of a bacteriocin, e...
July 10, 2018: Journal of Biotechnology
Sudarshan Murthy, Jenny Desantis, Patricia Verheugd, Mirko M Maksimainen, Harikanth Venkannagari, Serena Massari, Yashwanth Ashok, Ezeogo Obaji, Yves Nkizinkinko, Bernhard Lüscher, Oriana Tabarrini, Lari Lehtiö
Human Diphtheria toxin-like ADP-ribosyltranferases (ARTD) 10 is an enzyme carrying out mono-ADP-ribosylation of a range of cellular proteins and affecting their activities. It shuttles between cytoplasm and nucleus and influences signaling events in both compartments, such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling and S phase DNA repair. Furthermore, overexpression of ARTD10 induces cell death. We recently reported on the discovery of a hit compound, OUL35 (compound 1), with 330 nM potency and remarkable selectivity towards ARTD10 over other enzymes in the human protein family...
June 20, 2018: European Journal of Medicinal Chemistry
Huan Tang, Yongguang Zhang, Dan Li, Suhong Fu, Minghai Tang, Li Wan, Kai Chen, Zhuowei Liu, Linlin Xue, Aihua Peng, Haoyu Ye, Lijuan Chen
EGFR T790 M accounts for 50% to 60% of cases of non-small-cell lung carcinoma (NSCLC) resistance to the first-generation EGFR tyrosine kinase inhibitors (TKIs). Hence, identifying novel compounds with activity against TKIs resistant is of great value. In this study, twenty honokiol and magnolol derivatives were isolated from the EtOH extract of Magnolia officinalis and the antiproliferative activity was evaluated on HCC827 (19del EGFR mutation), H1975 (L858 R/T790 M EGFR mutation), and H460 (KRAS mutation) cell lines...
June 27, 2018: European Journal of Medicinal Chemistry
Yulong Zhang, Di Wang, Zao Zhang, Zhangping Wang, Daochuan Zhang, Hong Yin
To enhance genomic resources and understand the molecular immune mechanisms underlying the response topathogens, we first performed a comparative gene transcription analysis from Micrococcus lysodeikticus-immunized Artemia sinica and from a control group through RNA-Seq technology, meanwhile the differentially expressed genes (DEGs) were investigated. In total, 80, 113, 984 clean reads were obtained and then assembled into 71,536 unigenes with an average length of 1115 bp and an N50 of 1783 bp. Unigenes were annotated by comparing against nr, Swiss-Prot\KEGG\ COG\ KOG\ GO and Pfam databases, and 27,689 unigenes (38...
July 10, 2018: Fish & Shellfish Immunology
Maite Antonio, Carlota Gudiol, Cristina Royo-Cebrecos, Sara Grillo, Carmen Ardanuy, Jordi Carratalà
PURPOSE: To assess the etiology, clinical features and outcomes of bacteremia in older patients with solid tumors. METHODS: All episodes of bacteremia in hospitalized patients with solid tumors were prospectively collected. Patients aged ≥70 years were compared to patients aged <70 years. Risk factors for case-fatality rates in older patients were identified. RESULTS: We compared 217 episodes of bacteremia involving older patients and 525 occurring in younger patients...
July 10, 2018: Journal of Geriatric Oncology
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