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https://www.readbyqxmd.com/read/28918573/anti-inflammatory-effects-of-ginkgo-biloba-extract-against-trimethyltin-induced-hippocampal-neuronal-injury
#1
Sukhwinder Kaur, Neha Sharma, Bimla Nehru
BACKGROUND: Despite the immense neuromodulatory potentials of Ginkgo biloba extract as a memory enhancer, its underlying mechanism seems inadequate particularly with regard to its anti-inflammatory properties. AIM: The objective of the present study is to investigate the protective potentials of Ginkgo biloba extract (GBE) against hippocampal neuronal injury induced by trimethyltin (TMT), a potent neurotoxicant. METHODS: Male SD rats were administered trimethyltin (8...
September 16, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28918570/mathematical-description-of-drug-target-interactions-application-to-biologics-that-bind-to-targets-with-two-binding-sites
#2
Leonid Gibiansky, Ekaterina Gibiansky
The emerging discipline of mathematical pharmacology occupies the space between advanced pharmacometrics and systems biology. A characteristic feature of the approach is application of advance mathematical methods to study the behavior of biological systems as described by mathematical (most often differential) equations. One of the early application of mathematical pharmacology (that was not called this name at the time) was formulation and investigation of the target-mediated drug disposition (TMDD) model and its approximations...
September 16, 2017: Journal of Pharmacokinetics and Pharmacodynamics
https://www.readbyqxmd.com/read/28918546/systemic-effects-of-repeated-intraocular-dexamethasone-intravitreal-implant-in-diabetic-patients-a-retrospective-study
#3
Alicia Valverde-Megías, Pilar Cifuentes-Canorea, Jorge Ruiz-Medrano, Pablo Peña-García, Alicia Megías-Fresno, Juan Donate-López, Julián García-Feijoo
INTRODUCTION: The objective of this study is to evaluate the influence of repeated intraocular dexamethasone implant (Ozurdex) injections on metabolic control in type 2 diabetic patients. METHODS: Retrospective study of 165 type 2 diabetic patients starting Ozurdex treatment who received no less than three consecutive injections. Glycated hemoglobin (HbA1c), serum creatinine, total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides (TGs) were evaluated during 15 months of follow-up after Ozurdex treatment onset...
September 16, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28918372/enhanced-visible-light-photocatalytic-nitrogen-fixation-over-semicrystalline-graphitic-carbon-nitride-oxygen-and-sulfur-co-doping-for-crystal-and-electronic-structure-modulation
#4
Xiangwen Feng, Huan Chen, Fang Jiang, Xin Wang
Oxygen and sulfur co-doped semicrystalline graphitic carbon nitride (HGCNOS) was synthesized by a one-pot hydrothermal method and applied in visible-light photocatalytic nitrogen fixation. Remarkably, HGCNOS exhibited a higher photocatalytic activity than pristine graphitic carbon nitride (GCN). Oxygen doping caused semicrystalline structure, making exciton dissociated at the order-disorder interfaces of HGCNOS and releasing more electrons and holes. Furthermore, the conduction band position of HGCNOS was elevated by sulfur doping, promoting the reduction ability of HGCNOS...
September 8, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28918355/gallium-iii-chelates-of-mixed-phosphonate-carboxylate-triazamacrocyclic-ligands-relevant-to-nuclear-medicine-structural-stability-and-in-vivo-studies
#5
Maria I M Prata, João P André, Zoltán Kovács, Anett I Takács, Gyula Tircsó, Imre Tóth, Carlos F G C Geraldes
Three triaza macrocyclic ligands, H6NOTP (1,4,7-triazacyclononane-N,N',N″-trimethylene phosphonic acid), H4NO2AP (1,4,7-triazacyclononane-N-methylenephosphonic acid-N',N″-dimethylenecarboxylic acid), and H5NOA2P (1,4,7-triazacyclononane-N,N'-bis(methylenephosphonic acid)-N″-methylene carboxylic acid), and their gallium(III) chelates were studied in view of their potential interest as scintigraphic and PET (Positron Emission Tomography) imaging agents. A (1)H, (31)P and (71)Ga multinuclear NMR study gave an insight on the structure, internal dynamics and stability of the chelates in aqueous solution...
September 1, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28918291/distinguished-cr-vi-capture-with-rapid-and-superior-capability-using-polydopamine-microsphere-behavior-and-mechanism
#6
Qingrui Zhang, Yixuan Li, Qinggang Yang, He Chen, Xinqing Chen, Tifeng Jiao, Qiuming Peng
Toxic heavy metal containing Cr(VI) species is a serious threat for ecological environment and human beings. In this work, a new mussel-inspired polydopamine microsphere (PDA-sphere) is prepared through in situ oxidative polymerization at air condition with controllable sizes. The adsorption of Cr(VI) ions onto PDA-sphere is highly pH dependent with the optimal pH ranging from 2.5 to 3.8. A rapid Cr(VI) removal can approach in 8min for equilibrium. More importantly, the prepared materials exhibit a remarkable sorption selectivity, coexisting SO4(2-), NO3(-) and Cl(-) ions at high levels; The applicability model further proves its effective performances with treated capacity of 42,000kg/kg sorbent, and the effluent can be reduced from 2000ppb to below 50ppb, which meets the drinking water criterions recommended by WHO...
August 26, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28918220/synthesis-and-application-of-a-highly-selective-copper-ions-fluorescent-probe-based-on-the-coumarin-group
#7
Guangjie He, Xiangli Liu, Jinhe Xu, Liguo Ji, Linlin Yang, Aiying Fan, Songjun Wang, Qingzhi Wang
A highly selective copper ions fluorescent probe based on the coumarin-type Schiff base derivative 1 (probe) was produced by condensation reaction between coumarin carbohydrazide and 1H-indazole-3-carbaldehyde. The UV-vis spectroscopy showed that the maximum absorption peak of compound 1 appeared at 439nm. In the presence of Cu(2+) ions, the maximum peak decreased remarkably compared with other physiological important metal ions and a new absorption peak at 500nm appeared. The job's plot experiments showed that complexes of 1:2 binding mode were formed in CH3CN:HEPES (3:2, v/v) solution...
September 13, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28917972/research-on-the-antioxidant-wound-healing-and-anti-inflammatory-activities-and-the-phytochemical-composition-of-maritime-pine-pinus-pinaster-ait
#8
İbrahim Tümen, Esra Küpeli Akkol, Hakkı Taştan, Ipek Süntar, Mehmet Kurtca
ETHNOPHARMACOLOGICAL RELEVANCE: Ethnobotanical investigations have shown that the Pinus species have been used against rheumatic pain and for wound healing in Turkish folk medicine. MATERIAL AND METHODS: In this study, phytochemical composition, antioxidant, anti-inflammatory, and wound healing activities of Maritime Pine (Pinus pinaster Ait.) that is collected in Turkey are investigated. Essential oil composition and the amount of extracts (lipophilic and hydrophilic) of maritime pine wood and fresh cone samples had been tested...
September 13, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28917929/development-of-carboxymethyl-cellulose-chitosan-hybrid-micro-and-macroparticles-for-encapsulation-of-probiotic-bacteria
#9
P Singh, B Medronho, L Alves, G J da Silva, M G Miguel, B Lindman
Novel carboxymethyl cellulose-chitosan (CMC-Cht) hybrid micro- and macroparticles were successfully prepared in aqueous media either by drop-wise addition or via nozzle-spray methods. The systems were either physically or chemically crosslinked using genipin as the reticulation agent. The macroparticles (ca. 2mm) formed are found to be essentially of the core-shell type, while the microparticles (ca. 5μm) are apparently homogeneous. The crosslinked particles are robust, thermally resistant and less sensitive to pH changes...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28917847/release-of-polyphenols-from-starch-chitosan-based-films-containing-thyme-extract
#10
Emma Talón, Kata T Trifkovic, María Vargas, Amparo Chiralt, Chelo González-Martínez
The release kinetics of thyme extract polyphenols (TE) from chitosan (CH), pea starch (S) and CH:S blend films in different solvents was evaluated, as well as their antioxidant activity in each release media. Pure starch films showed the fastest delivery rate and the highest delivery ratio of polyphenols, although the corresponding release media exhibited the lowest antioxidant capacity. TE provided CH based films with remarkable antioxidant activity, despite the lower polyphenol release obtained in all solvents, due to the strong polyphenols-chitosan interactions...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28917816/crystalline-phase-dependent-eco-toxicity-of-titania-nanoparticles-to%C3%A2-freshwater-biofilms
#11
Kun Li, Jin Qian, Peifang Wang, Chao Wang, Jingjing Liu, Xin Tian, Bianhe Lu, Mengmeng Shen
The potential toxic impacts of different crystal phases of titania nanoparticles (TNPs) on freshwater biofilms, especially under ultraviolet C irradiation (UVC), are unknown. Here, adverse impacts of three phases (anatase, rutile, and P25, 50 mg L(-1) respectively) with UVC irradiation (An-UV, Ru-UV, and P25-UV) on freshwater biofilms were conducted. Characterization experiments revealed that rutile TNPs had a higher water environment stability than anatase and P25 TNPs, possessing a stronger photocatalytic activity under UVC irradiation...
September 13, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28917766/a-novel-colorimetric-and-ratiometric-fluorescent-probe-for-visualizing-so2-derivatives-in-environment-and-living-cells
#12
Zhuo Ye, Chong Duan, Ruilong Sheng, Junchao Xu, Hongying Wang, Lintao Zeng
Monitoring sulfur dioxide (SO2) derivatives in environment is of great significance due to their harmful effects to the environment and human health. In this study, a fluorescent probe (CZBT) for SO2 derivatives was prepared from 9-ethyl-9H-carbazole-3,6-dicarboxaldehyde and 2-methyl-benzothiazolium, which displayed a noticeable color change from yellow to colorless along with a remarkable fluorescence change from yellow to blue in response to HSO3(-). The probe could quantitatively determine the concentration of HSO3(-) with excellent selectivity, high sensitivity and low limit of detection...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28917746/a-highly-selective-and-ratiometric-fluorescent-probe-for-cyanide-by-rationally-altering-the-susceptible-h-atom
#13
Yuanqiang Hao, Khac Hong Nguyen, Yintang Zhang, Guan Zhang, Shengnan Fan, Fen Li, Chao Guo, Yuanyuan Lu, Xiaoqing Song, Peng Qu, You-Nian Liu, Maotian Xu
A highly selective and ratiometric fluorescent probe for cyanide was rationally designed and synthesized. The probe comprises a fluorophore unit of naphthalimide and a CN(-) acceptor of methylated trifluoroacetamide group. For these previous reported trifluoroacetamide derivative-based cyanide chemosensors, the H-atom of amide adjacent to trifluoroacetyl group is susceptible to be attacked by various anions (CN(-) itself, F(-), AcO(-), et al.) and even the solvent molecule, which resulted in the bewildered reaction mechanism and poor selectivity of the assay...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28917489/the-effects-of-single-or-combined-administration-of-galactooligosaccharide-and-pediococcus-acidilactici-on-cutaneous-mucus-immune-parameters-humoral-immune-responses-and-immune-related-genes-expression-in-common-carp-cyprinus-carpio-fingerlings
#14
Maryam Modanloo, Siavash Soltanian, Mostafa Akhlaghi, Seyed Hossein Hoseinifar
The present study was performed to investigate the effects of single or combined administration of galactooligosaccharide (GOS) and Pediococcus acidilactici on cutaneous mucus immune parameters, humoral immune responses and immune related genes expression in common carp (Cyprinus carpio) fingerlings. Carps were fed experimental diets for 8 weeks as follows: non-supplemented (Control), prebiotic diet (10 g/kg GOS), probiotic diet (1 g/kg [0.9 × 10(7) CFU] lyophilized P. acidilactici) and synbiotic diet (10 GOS in combination with 1 g/kg [0...
September 13, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28917414/chemical-and-physical-analysis-of-phaco-handpiece-tip-surfaces-before-and-after-cataract%C3%A2-surgery
#15
Paolo Cecchini, Rossella D'Aloisio, Manlio Antonuccio, Gianluca Turco, Federica Bondino, Elena Magnano, Marta Di Nicola, Daniele Tognetto
PURPOSE: To evaluate the surface chemical composition and roughness of different phaco tips before and after their use during cataract surgery. SETTING: Eye Clinic, University of Trieste, Trieste, Italy. DESIGN: Experimental study. METHODS: Of the 66 tips studied, 33 (15 new, 15 after single use, and 3 after multiple uses) were studied with X-ray photoemission spectroscopy and 33 (15 new, 15 after single use, and 3 after multiple uses) were examined using scanning electron microscopy with energy dispersive X-ray spectroscopy analysis and contact profilometry...
August 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28917174/potential-effects-of-changes-in-climate-and-emissions-on-distribution-and-fate-of-perfluorooctane-sulfonate-in-the-bohai-rim-china
#16
Chao Su, Shuai Song, Yonglong Lu, Shijie Liu, John P Giesy, Deliang Chen, Alan Jenkins, Andrew J Sweetman, Baninla Yvette
Climate change and emissions rates of contaminants are expected to affect distribution and fate of Persistent Organic Pollutants (POPs) in the environment, however, studies on these combined factors are rare. In this study, Perfluorooctane Sulfonate (PFOS) is used as an example to assess how those two factors synthetically affect fate and disposition of POPs in the Bohai Rim of China by using the Berkeley-Trent-Urban-Rural (BETR-Urban-Rural) model. We set up three climate change scenarios and four emission scenarios to conduct the simulations...
September 13, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28916913/centromeric-enrichment-of-line-1-retrotransposons-and-its-significance-for-the-chromosome-evolution-of-phyllostomid-bats
#17
Cibele Gomes de Sotero-Caio, Diogo Cavalcanti Cabral-de-Mello, Merilane da Silva Calixto, Guilherme Targino Valente, Cesar Martins, Vilma Loreto, Maria José de Souza, Neide Santos
Despite their ubiquitous incidence, little is known about the chromosomal distribution of long interspersed elements (LINEs) in mammalian genomes. Phyllostomid bats, characterized by lineages with distinct trends of chromosomal evolution coupled with remarkable ecological and taxonomic diversity, represent good models to understand how these repetitive sequences contribute to the evolution of genome architecture and its link to lineage diversification. To test the hypothesis that LINE-1 sequences were important modifiers of bat genome architecture, we characterized the distribution of LINE-1-derived sequences on genomes of 13 phyllostomid species within a phylogenetic framework...
September 15, 2017: Chromosome Research
https://www.readbyqxmd.com/read/28916789/whole-body-and-hematopoietic-adam8-deficiency-does-not-influence-advanced-atherosclerotic-lesion-development-despite-its-association-with-human-plaque-progression
#18
Kosta Theodorou, Emiel P C van der Vorst, Marion J Gijbels, Ine M J Wolfs, Mike Jeurissen, Thomas L Theelen, Judith C Sluimer, Erwin Wijnands, Jack P Cleutjens, Yu Li, Yvonne Jansen, Christian Weber, Andreas Ludwig, Jacob F Bentzon, Jörg W Bartsch, Erik A L Biessen, Marjo M P C Donners
Although A Disintegrin And Metalloproteinase 8 (ADAM8) is not crucial for tissue development and homeostasis, it has been implicated in various inflammatory diseases by regulating processes like immune cell recruitment and activation. ADAM8 expression has been associated with human atherosclerosis development and myocardial infarction, however a causal role of ADAM8 in atherosclerosis has not been investigated thus far. In this study, we examined the expression of ADAM8 in early and progressed human atherosclerotic lesions, in which ADAM8 was significantly upregulated in vulnerable lesions...
September 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28916782/predicting-clinical-outcomes-from-large-scale-cancer-genomic-profiles-with-deep-survival-models
#19
Safoora Yousefi, Fatemeh Amrollahi, Mohamed Amgad, Chengliang Dong, Joshua E Lewis, Congzheng Song, David A Gutman, Sameer H Halani, Jose Enrique Velazquez Vega, Daniel J Brat, Lee A D Cooper
Translating the vast data generated by genomic platforms into accurate predictions of clinical outcomes is a fundamental challenge in genomic medicine. Many prediction methods face limitations in learning from the high-dimensional profiles generated by these platforms, and rely on experts to hand-select a small number of features for training prediction models. In this paper, we demonstrate how deep learning and Bayesian optimization methods that have been remarkably successful in general high-dimensional prediction tasks can be adapted to the problem of predicting cancer outcomes...
September 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28916771/complete-fusion-of-a-transposon-and-herpesvirus-created-the-teratorn-mobile-element-in-medaka-fish
#20
Yusuke Inoue, Tomonori Saga, Takumi Aikawa, Masahiko Kumagai, Atsuko Shimada, Yasushi Kawaguchi, Kiyoshi Naruse, Shinichi Morishita, Akihiko Koga, Hiroyuki Takeda
Mobile genetic elements (e.g., transposable elements and viruses) display significant diversity with various life cycles, but how novel elements emerge remains obscure. Here, we report a giant (180-kb long) transposon, Teratorn, originally identified in the genome of medaka, Oryzias latipes. Teratorn belongs to the piggyBac superfamily and retains the transposition activity. Remarkably, Teratorn is largely derived from a herpesvirus of the Alloherpesviridae family that could infect fish and amphibians. Genomic survey of Teratorn-like elements reveals that some of them exist as a fused form between piggyBac transposon and herpesvirus genome in teleosts, implying the generality of transposon-herpesvirus fusion...
September 15, 2017: Nature Communications
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