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https://www.readbyqxmd.com/read/29785743/four-new-diterpenoid-alkaloids-from-the-roots-of-aconitum-carmichaelii
#1
Yu Li, Feng Gao, Ji-Fa Zhang, Xian-Li Zhou
Aconitum carmichaelii, belonging to the Ranunculaceae family, is mainly distributed and cultivated in southwestern China. Its parent and lateral roots, two well-known traditional medicinal materials, are commonly called as "Chuanwu" and "Fuzi" in China, respectively. A. carmichaelii is widely used for the treatment of cadianeuria, neuralgia, and rheumatalgia in Chinese medicine. According to the pharmacology studies, diterpenoid alkaloids accounted for the major effects and toxicity of this plant, such as hypaconitine, mesaconitine, aconitine...
May 21, 2018: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29758520/probing-the-transcriptome-of-aconitum-carmichaelii-reveals-the-candidate-genes-associated-with-the-biosynthesis-of-the-toxic-aconitine-type-c-19-diterpenoid-alkaloids
#2
Dake Zhao, Yong Shen, Yana Shi, Xingqiao Shi, Qin Qiao, Shuhui Zi, Erqiang Zhao, Diqiu Yu, Edward J Kennelly
Aconitum carmichaelii has long been used as a traditional Chinese medicine, and its processed lateral roots are known commonly as fuzi. Aconitine-type C19 -diterpenoid alkaloids accumulating in the lateral roots are some of the main toxicants of this species, yet their biosynthesis remains largely unresolved. As a first step towards understanding the biosynthesis of aconitine-type C19 -diterpenoid alkaloids, we performed de novo transcriptome assembly and analysis of rootstocks and leaf tissues of Aconitum carmichaelii by next-generation sequencing...
May 11, 2018: Phytochemistry
https://www.readbyqxmd.com/read/29699844/research-on-q-markers-of-qiliqiangxin-capsule-for-chronic-heart-failure-treatment-based-on-pharmacokinetics-and-pharmacodynamics-association
#3
Fugeng Zhang, Yu Zhang, Xiaofeng Li, Shaoqiang Zhang, Mingdan Zhu, Wuxun Du, Xuefeng Xiao
BACKGROUND: Qiliqiangxin capsule (QLQX), composed of 11 herbs, is an effective traditional Chinese medicine (TCM) that has been widely used for treatment of chronic heart failure (CHF) in China. In the Chinese pharmacopoeia (Ch.P.) only astragaloside was described as the marker component to control the quality of QLQX, which could not reflect the overall effectiveness. PURPOSE: The aim of this work was to investigate the quality markers (Q-markers) of QLQX based on the association of the pharmacodynamics (PD) of inhibitory effect on activated renin-angiotensin-aldosterone system (RAAS) and the pharmacokinetics (PK) of bioactive compounds according to the Q-marker theory...
March 21, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29600653/-content-determination-of-four-diester-diterpenoid-alkaloids-in-leaves-of-aconitum-kusnezoffii-by-hplc
#4
Ke Zan, Ci-Ren Wangjie, Jing Lu, Li-Nong Guo, Jian Zheng, Shuang-Cheng Ma
This present study is to develop an HPLC method for simultaneous determination of four diester diterpenoid alkaloids, beiwutine, mesaconitine, hypaconitine and aconitine in the leaves of Aconitum kusnezoffii, so as to provide evidence of the quality control of this herb. The four constituents were measured on a Waters XBridge CC₁₈ column(4.6 mmχ250 mm, 5 μm). The mobile phase was acetonitrile-40 mmol·L⁻¹ ammonium acetate solution(adjusted pH to 10.5 with ammonia solution)(33:67) with isocratic elution at a flow rate of 1...
February 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29552836/-establishment-and-verification-of-risk-assessment-scale-for-clinical-safety-medication-of-aconitine
#5
Rui Jin, Yu-Guang Wang, Bing Zhang
Chinese patent medicine containing aconitine is the key in clinical rational drug use. These drugs contain Chuanwu, Caowu or Fuzi, and Aconitum brachypodum with functions of expelling wind-dampness or tonifying Yang, all of which shall be used by strictly following the indications and dosage. However, there are many kinds of such drugs. Not only the unfamiliar knowledge of some Chinese and Western physicians about the characteristics of them, but also the combination of multiple drugs from different clinical departments, would increase the risk of aconitine poisoning...
January 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29512824/improved-cardiac-outcomes-with-combined-atenolol-and-diazepam-intervention-in-seizure
#6
Morgayn I Read, Rebecca N Millen, Dominic M McCann, Joanne C Harrison, Douglas S Kerr, Ivan A Sammut
OBJECTIVE: Altered autonomic activity has been implicated in the development of cardiac dysfunction during seizures. This study investigates whether intervening in seizure progression with diazepam will reduce seizure-induced cardiomyopathy. Second, this study examines the hypothesis that combining atenolol with diazepam, as an intervention after seizure onset, will combat cardiac injury during status epilepticus. METHODS: Male Sprague-Dawley rats were implanted with electroencephalographic/electrocardiographic electrodes to allow simultaneous recordings during seizures induced by intrahippocampal (2 nmol, 1 μL) kainic acid (KA)...
April 2018: Epilepsia
https://www.readbyqxmd.com/read/29461247/-alkaloids-of-underground-parts-of-georgian-flora-s-aconitum-orientale-mill-and-aconitum-nasutum-fisch-ex-reichemb-and-their-biological-activity
#7
L Kintsurashvili, V Mshvildadze, T Suladze
The aim of research was to study underground parts of Aconitum orientale Mill and Aconitum nasutum Fisch exReichemb for the composition of biological active diterpenic alkaloids. The research object was underground parts of Aconitum species. Alkaloids sum was received from raw-material which was alkalined beforehand with chloroform extraction. From the results of research we established, that both species of Georgian flora's Aconitum contains alkaloids: lappaconitine, aconitine, karakoline. Underground parts of Aconitum orientale and Aconitum nasutum differ from eath other with composition of alkaloids spectrum...
January 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29429799/accelerated-idioventricular-rhythm-degenerating-into-bidirectional-ventricular-tachycardia-following-acute-myocardial-infarction
#8
Yun-Tao Zhao, Hang Zhou, Yumin Cui
Bidirectional ventricular tachycardia (BVT) is a rare ventricular tachyarrhythmia. It is usually regular, demonstrating a beat-to-beat alternation in the QRS frontal axis that varies between -20° to -30° and +110°. The tachycardia rate is typically between 140 and 180 beats/min and the QRS is relatively narrow, with a duration of 120 to 150 ms. The etiology of published BVT cases is most commonly digitalis toxicity and, rarely, herbal aconitine poisoning, hypokalemic periodic paralysis, catecholaminergic polymorphic ventricular tachycardia (CPVT), myocarditis, and Andersen-Tawil syndrome...
April 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29404034/effect-of-processing-on-the-alkaloids-in-aconitum-tubers-by-hplc-tof-ms
#9
Min Liu, Yan Cao, Diya Lv, Wen Zhang, Zhenyu Zhu, Hai Zhang, Yifeng Chai
According to the Chinese Pharmacopoeia 2015, only processed Aconitum tubers can be clinically applied, and the effect of processing is unclear. This research aimed to explore the effect of processing on cardiac efficacy of alkaloids in Aconitum tubers. First, the chemical ingredients in unprocessed and processed Aconitum tubers were identified and compared by using high performance liquid chromatography time-of-flight mass spectrometry (HPLC-TOF/MS) and multivariate pattern recognition methods. Then the representative alkaloids in Aconitum tubers, aconitine, benzoylaconine, and aconine, which belong to diester-diterpenoid alkaloids, monoester-diterpenoid alkaloids, and amine-diterpenoid alkaloids, respectively, were selected for further validation of attenuated mechanism...
June 2017: Journal of Pharmaceutical Analysis
https://www.readbyqxmd.com/read/29324796/quercetin-and-aconitine-synergistically-induces-the-human-cervical-carcinoma-hela-cell-apoptosis-via-endoplasmic-reticulum-er-stress-pathway
#10
Xiu-Mei Li, Jing Liu, Fang-Fang Pan, Dong-Dong Shi, Zhi-Guo Wen, Pei-Long Yang
Up till now, studies have not been conducted on how the combination of Quercetin (Q), Aconitine (A) and apoptosis induction affects human cervical carcinoma HeLa cells. The result of our findings shows that the combination of Q and A (QA) is capable of synergistically inhibiting the proliferation of HeLa cells in a number of concentrations. QA synergistically inhibits the proliferation of MDR1 gene in the HeLa cells. It is concluded based on our result that QA induces apoptosis and ER stress just as QA-induced ER stress pathway may mediate apoptosis by upregulating mRNA expression levels of eIF2α, ATF4, IRE1, XBP1, ATF6, PERK and CHOP in the HeLa cells...
2018: PloS One
https://www.readbyqxmd.com/read/29277460/aconitum-alkaloids-the-major-components-of-aconitum-species-affect-expression-of-multidrug-resistance-associated-protein-2-and-breast-cancer-resistance-protein-by-activating-the-nrf2-mediated-signalling-pathway
#11
Jin-Jun Wu, Yuan-Feng Zhu, Zhen-Zhen Guo, Yan-Mei Lou, Shu-Gui He, Yang Guan, Li-Jun Zhu, Zhong-Qiu Liu, Lin-Lin Lu, Liang Liu
BACKGROUND: Aconitum alkaloids from Aconitum species are often used to treat arthritis and rheumatic diseases but have the drawback of high toxicity. Identifying their pharmacokinetic behaviour is important for the safe clinical application of Aconitum species. Efflux transporters (ETs), including P-glycoprotein (P-gp), multidrug resistance-associated protein 2 (MRP2), and breast cancer resistance protein (BCRP), have important functions in regulating the pharmacokinetic behaviours of drugs and in herb-herb or herb-drug interactions (HDIs)...
December 8, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29212360/a-new-denudatine-type-c-20-diterpenoid-alkaloid-from-aconitum-sinchiangense-w-t-wang
#12
Ahmatbeck Samanbay, Bo Zhao, Haji Akber Aisa
A new denudatine-type C20 -diterpenoid alkaloid, designated as sinchianine (1), together with eight known diterpenoid alkaloids, 12-acetyl-12-epi-napelline (2), 12-epi-napelline (3), neoline (4), talatisamine (5), 14-O-acetylsenbusine A (6) and benzoylaconine (7), songorine (8) and aconitine (9), were isolated from the whole herb of Aconitum sinchiangense W. T. Wang. Their structures were elucidated on the basis of extensive spectroscopic analyses (NMR and HR-ESI-MS) and comparison with data reported in the literature...
December 6, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29206203/de-novo-rna-sequencing-and-expression-analysis-of-aconitum-carmichaelii-to-analyze-key-genes-involved-in-the-biosynthesis-of-diterpene-alkaloids
#13
Megha Rai, Amit Rai, Noriaki Kawano, Kayo Yoshimatsu, Hiroki Takahashi, Hideyuki Suzuki, Nobuo Kawahara, Kazuki Saito, Mami Yamazaki
Aconitum carmichaelii is an important medicinal herb used widely in China, Japan, India, Korea, and other Asian countries. While extensive research on the characterization of metabolic extracts of A. carmichaelii has shown accumulation of numerous bioactive metabolites including aconitine and aconitine-type diterpene alkaloids, its biosynthetic pathway remains largely unknown. Biosynthesis of these secondary metabolites is tightly controlled and mostly occurs in a tissue-specific manner; therefore, transcriptome analysis across multiple tissues is an attractive method to identify the molecular components involved for further functional characterization...
December 5, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29160852/the-complete-chloroplast-genome-sequences-of-aconitum-pseudolaeve-and-aconitum-longecassidatum-and-development-of-molecular-markers-for-distinguishing-species-in-the-aconitum-subgenus-lycoctonum
#14
Inkyu Park, Sungyu Yang, Goya Choi, Wook Jin Kim, Byeong Cheol Moon
Aconitum pseudolaeve Nakai and Aconitum longecassidatum Nakai, which belong to the Aconitum subgenus Lycoctonum, are distributed in East Asia and Korea. Aconitum species are used in herbal medicine and contain highly toxic components, including aconitine. A. pseudolaeve, an endemic species of Korea, is a commercially valuable material that has been used in the manufacture of cosmetics and perfumes. Although Aconitum species are important plant resources, they have not been extensively studied, and genomic information is limited...
November 21, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29115599/aconitine-induces-apoptosis-in-h9c2-cardiac-cells-via-mitochondria%C3%A2-mediated-pathway
#15
Xiangting Gao, Xincai Zhang, Jun Hu, Xuehua Xu, Yuanyi Zuo, Yun Wang, Jingfeng Ding, Hongfei Xu, Shaohua Zhu
Aconitine, a diterpenoid alkaloids derived from Aconitum plants, is widely employed to treat various diseases. The aim of the present study was to investigate the apoptotic effect of aconitine in H9c2 cardiac cells. H9c2 cell apoptosis induced by aconitine was detected by a Cell Counting kit‑8 assay, DAPI staining, Annexin V‑FITC/propidium iodide double staining and western blotting. The effects of aconitine on reactive oxygen species levels and mitochondrial membrane potential were confirmed by fluorescence microscopy and flow cytometry...
January 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29109516/cytotoxicity-of-aconitum-alkaloid-and-its-interaction-with-calf-thymus-dna-by-multi-spectroscopic-techniques
#16
Fei Liu, Xiaoxin Tan, Xu Han, Xiang Li, Nan Li, Weijun Kang
The cytotoxicities of three aconitum alkaloids- aconitine, hypaconitine and mesaconitine, and their abilities to bind DNA have been explored. Rat myocardial cells H9c2 were treated with aconitum alkaloids and assessed the cytotoxicities by using MTT assay and flow cytometry. Apoptosis was evidenced by the results of the annexin V/propidium iodide (PI) assay. Aconitine was found to be the most toxic in rat myocardial cells H9c2 in three aconitum alkaloids. At the same time, DNA adducts were isolated and then analyzed by UV-Vis spectroscopy after exposure to alkaloids, which indicated that three alkaloids could bind to DNA in rat myocardial cells H9c2...
November 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29082700/-anti-inflammatory-mechanism-analysis-of-antirheumatic-chinese-medicinal-herb-aconiti-radix-based-on-protein-interaction-network
#17
Shi-Chao Zheng, Xiao-Ying Yan, Ju Chen, Shu-Ting Zhao, Chuan-Biao Wen
Inflammation is one of the important risk factors of rheumatic diseases. Aconiti Radix is widely used for the treatment of rheumatism, which has significant anti-inflammatory effects. However, its anti-inflammatory mechanism on molecular level is still not clear. The purpose of this study is to illuminate the anti-inflammatory mechanism of Aconiti Radix based on the protein interaction network (PIN) analysis on molecular network level. The main anti-inflammatory components (aconitine, hypaconitine and mesaconitine) were chosen in this study to obtain the targets of the components and protein-protein information though databases retrieval and construct the PIN of Aconiti Radix...
May 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29076119/identification-of-potential-biomarkers-from-aconitum-carmichaelii-a-traditional-chinese-medicine-using-a-metabolomic-approach
#18
Dake Zhao, Yana Shi, Xinyan Zhu, Li Liu, Pengzhang Ji, Chunlin Long, Yong Shen, Edward J Kennelly
Despite their well-known toxicity, Aconitum species are important traditional medicines worldwide. Aconitum carmichaelii, known in Chinese as (fuzi), is an officially recognized traditional Chinese medicine with characteristic analgesic and anti-inflammatory activities, whose principal pharmacological ingredients are considered as aconitine-type diterpene alkaloids. Notwithstanding the long-recorded use of A. carmichaelii in traditional Chinese medicine, no single-entity aconitum alkaloid drug has been developed for clinical use...
October 26, 2017: Planta Medica
https://www.readbyqxmd.com/read/29072259/barbaloin-inhibits-ventricular-arrhythmias-in-rabbits-by-modulating-voltage-gated-ion-channels
#19
Zhen-Zhen Cao, You-Jia Tian, Jie Hao, Pei-Hua Zhang, Zhi-Pei Liu, Wan-Zhen Jiang, Meng-Liu Zeng, Pei-Pei Zhang, Ji-Hua Ma
Barbaloin (10-β-D-glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-9(10H)-anthracenone) is extracted from the aloe plant and has been reported to have anti-inflammatory, antitumor, antibacterial, and other biological activities. Here, we investigated the effects of barbaloin on cardiac electrophysiology, which has not been reported thus far. Cardiac action potentials (APs) and ionic currents were recorded in isolated rabbit ventricular myocytes using whole-cell patch-clamp technique. Additionally, the antiarrhythmic effect of barbaloin was examined in Langendorff-perfused rabbit hearts...
March 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29063180/serum-lipid-feature-and-potential-biomarkers-of-lethal-ventricular-tachyarrhythmia-lvta-induced-by-myocardial-ion-channel-diseases-a-rat-model-study
#20
Jiayan Wu, Qian Wu, WenTao Dai, Jing Kong, Junyao Lv, Xiaojun Yu, Xingxing Wang, Dian Wang
To determine the cause of death in myocardial ion channel diseases (MICD)-induced sudden cardiac death (SCD) cases is a difficulty in forensic identification practices. The majority of MICD-induced SCD cases would experience lethal ventricular tachyarrhythmia (LVTA) before deaths; thus, confirming the occurrence of LVTA in bodies can offer a key evidence to identify these cases. Several lipids in the myocardia were found disturbed after LVTA; yet, whether serum lipidome would be disrupted by LVTA is not clear...
March 2018: International Journal of Legal Medicine
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