Ya-Juan Guo, Jing-Jing Yao, Zhen-Zhen Guo, Ming Ding, Kun-Lin Zhang, Qing-Hong Shen, Yu Li, Shao-Fang Yu, Ting Wan, Fu-Ping Xu, Ying Wang, Xiao-Xiao Qi, Jin-Jun Wu, Jian-Xin Chen, Zhong-Qiu Liu, Lin-Lin Lu
The root of Aconitum carmichaelii Debx. (Fuzi) is an herbal medicine used in China that exerts significant efficacy in rescuing patients from severe diseases. A key toxic compound in Fuzi, aconitine (AC), could trigger unpredictable cardiotoxicities with high-individualization, thus hinders safe application of Fuzi. In this study we investigated the individual differences of AC-induced cardiotoxicities, the biomarkers and underlying mechanisms. Diversity Outbred (DO) mice were used as a genetically heterogeneous model for mimicking individualization clinically...
March 11, 2024: Acta Pharmacologica Sinica