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https://www.readbyqxmd.com/read/28551933/-recommendations-for-the-diagnosis-and-management-of-pediatric-acute-gastroenteritis-in-israel-update-2017
#1
Firas Rinawi, Shai Ashkenazi, Michael Wilschanski, Eli Somekh, Raanan Shamir
AIMS: The aim of these guidelines is to update and extend evidence-based recommendations for the diagnosis and management of children with acute gastroenteritis (AGE) in Israel, based on new data and the recently published European update. METHODS: The recommendations, which are based on a systematic review of the literature, were graded by the level of evidence. The guidelines were endorsed by the Israeli societies for Pediatric Gastroenterology, Pediatric Infectious Diseases and the Israeli Association of Pediatrics...
March 2017: Harefuah
https://www.readbyqxmd.com/read/28551929/-early-in-hospital-mortality-in-internal-medicine-wards-within-24-hours-a-potential-quality-indicator-or-a-variable-affected-by-multiple-factors
#2
Yaron Niv, Evgeny Berkov, Pazit Kanter, Evgeny Abrahmson, Uri Gabbay
AIMS: To evaluate in-hospital mortality rate within 24 hours in internal medicine wards and to evaluate if it may be used as quality indicator. BACKGROUND: In-hospital mortality rate is an outcome measure which apparently reflects quality of care. There are debates on whether it may be considered a quality indicator since it is difficult to compare different case-mixes between hospitals. Research on mortality within 24 hours had not been published. METHODS: An historical prospective study was conducted including the entire internal wards admissions to the Rabin Medical Center between 1/7/14 and 30/6/15...
April 2017: Harefuah
https://www.readbyqxmd.com/read/28551890/-the-challenge-of-providing-high-standard-medical-services-in-a-public-hospital
#3
Shay Nathanson, Carlos Gruzman
Kaplan Medical Center (KMC) provides medical services to about 1 million Israeli citizens. The southern plain region is one of the leading areas in terms of population growth in Israel and as a result, the demand for medical services is constantly on the rise. The workload at KMC is tremendous; over 140,000 referrals to the emergency department with a 6% increase each year. Bed occupancy in the internal wards is above 120% on average per year (the highest in Israel) and ambulatory care referrals are rising at an overwhelming pace...
February 2017: Harefuah
https://www.readbyqxmd.com/read/28551843/incidence-and-risk-factors-of-febrile-neutropenia-in-patients-with-non-hodgkin-b-cell-lymphoma-receiving-r-chop-in-a-single-center-in-japan
#4
Masahiro Yokoyama, Yoshiharu Kusano, Anna Takahashi, Norihito Inoue, Kyoko Ueda, Noriko Nishimura, Yuko Mishima, Yasuhito Terui, Tomoyuki Nukada, Takanobu Nomura, Kiyohiko Hatake
PURPOSE: The incidence of and risk factors for febrile neutropenia (FN) in Japanese non-Hodgkin B-cell lymphoma (B-NHL) patients receiving rituximab, cyclophosphamide, doxorubicin, vincristine, and predonisolone (R-CHOP) chemotherapy are unknown. We conducted this study to address this issue. METHODS: In this single-center, retrospective, observational study, 466 patients with B-NHL who completed an R-CHOP regimen within a 7-year period and who planned to undergo at least three cycles of this regimen were analyzed...
May 27, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28551684/exhaled-breath-condensate-acidification-occurs-during-surgery-for-abdominal-cancer
#5
Archontia Mahairidou, Sophia Rodopoulou, Ioannis Tomos, Eirini Maratou, Effrosyni Manali, Thomas Raptakis, Spyros A Papiris, Anna Karakatsani
BACKGROUND/AIM: Acidification of exhaled breath condensate (EBC), reflecting airway inflammation and oxidative stress, has been reported in lung cancer patients undergoing lobectomy. We undertook this study to examine EBC pH changes during surgery for abdominal cancer. PATIENTS AND METHODS: EBC pH was measured from 20 patients undergoing abdominal cancer resection before and during surgery. Repeated-measures of ANOVA and random-effects linear models were applied to compare mean EBC pH values in samples collected at different times...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551677/serum-levels-of-igf-1-and-igfbp-3-in-relation-to-clinical-and-pathobiological-aspects-of-head-and-neck-squamous-cell-carcinomas
#6
David Kalfert, Marie Ludvikova, Ondrej Topolcan, Petr Celakovsky, Radek Kucera, Jindra Windrichova, Jaroslav Ludvik, Katerina Skalova, Vlastimil Kulda, Martin Pesta, Jan Plzak
BACKGROUND/AIM: Head and neck squamous cell carcinoma (HNSCC) includes tumors of various anatomical sites sharing multifactorial etiopathogenesis and generally dismal response to conventional treatment. The objective of this study was to determine the clinical significance of serum levels of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-binding protein-3 (IGFBP-3) in HNSCC. PATIENTS AND METHODS: A total of 46 patients, with histologically-confirmed diagnosis of HNSCC (21 oropharyngeal, 21 laryngeal, and 4 hypopharyngeal cancers) were enrolled in this study...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551637/17-allylamino-17-demethoxygeldanamycin-induced-changes-in-18-f-fluorothymidine-uptake
#7
Hang Jung Lee, DO Hyung Kim, Seung Jin Lee
The proliferation status of tumor cells can be imaged using [(18)F]fluorothymidine ([(18)F]FLT), which is trapped by cell cycle-dependent thymidine kinase 1 (TK1). Targeting of heat shock protein 90 (HSP90) disrupts multiple client proteins, leading to heterogeneous cell-cycle phenotypes. To investigate whether [(18)F]FLT uptake reflects the growth arrest caused by various mechanisms of HSP90 inhibition, we used HCT116 cells that were arrested at G0/G1 phase, and Hep3B cells at G2/M phase, by the HSP90 inhibitor 17-AAG...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551567/-no-place-like-home-aging-in-post-reform-beijing
#8
Jie Yu, Mark W Rosenberg
This study shows the Western theorization and interpretation of aging, place and health are not well suited to a non-western case. The current generation of older Chinese has experienced the transition from a planned economy to a socialist market economy. Urban changes have taken place in various ways. This study explains the spatio-temporal processes of older people with their changing places by conducting in-depth interviews with 47 older people living at home in Beijing. Their generational consciousness and old place identities are deeply rooted in pre-reform Collectivism and shaped by socialist ideologies of the past...
May 25, 2017: Health & Place
https://www.readbyqxmd.com/read/28551555/decreased-medial-prefrontal-cortex-activation-during-self-referential-processing-in-bipolar-mania
#9
Dorrit Herold, Tatiana Usnich, Stephanie Spengler, Bastian Sajonz, Michael Bauer, Felix Bermpohl
BACKGROUND: Patients with bipolar disorder in mania exhibit symptoms pointing towards altered self-referential processing, such as decreased self-focus, flight of ideas and high distractibility. In depression, the opposite pattern of symptoms has been connected to increased activation of medial prefrontal cortex (mPFC) during self-referential processing. In this study, we hypothesized that (1) patients with mania will exhibit decreased activation in the mPFC during self-referential processing and (2) will be more alexithymic and that levels of alexithymia will correlate negatively with mPFC activation...
April 27, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28551541/variation-partitioning-of-benthic-diatom-community-matrices-effects-of-multiple-variables-on-benthic-diatom-communities-in-an-austral-temperate-river-system
#10
Tatenda Dalu, Ryan J Wasserman, Mandla L Magoro, Tongayi Mwedzi, P William Froneman, Olaf L F Weyl
This study explores diatom community dynamics in a highly modified semi-arid temperate region river system characterised by inconsistent river flow. Various water and sediment environmental variables were assessed using a multi-faceted analysis approach to determine the spatio-temporal drivers of benthic diatom communities in the river system. Overall, the diatom community was generally dominated by pollution tolerant species, reflecting the anthropogenic intensity and activities on the river system. Diatom community composition was found to be largely determined by water column chemistry variables particularly nutrient concentrations in comparison to sediment chemistry and physical variables...
May 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28551537/the-effects-of-non-native-signal-crayfish-pacifastacus-leniusculus-on-fine-sediment-and-sediment-biomonitoring
#11
Matt D Turley, Gary S Bilotta, Antonio Gasparrini, Francesco Sera, Kate L Mathers, Ian Humpheryes, Judy England
The North American signal crayfish (Pacifastacus leniusculus) has invaded freshwater ecosystems across Europe. Recent studies suggest that predation of macroinvertebrates by signal crayfish can affect the performance of freshwater biomonitoring tools used to assess causes of ecological degradation. Given the reliance on biomonitoring globally, it is crucial that the potential influence of invasive species is better understood. Crayfish are also biogeomorphic agents, and therefore, the aim of this study was to investigate whether sediment-biomonitoring tool outputs changed following signal crayfish invasions, and whether these changes reflected post-invasion changes to deposited fine sediment, or changes to macroinvertebrate community compositions unrelated to fine sediment...
May 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28551511/the-effects-of-foot-cooling-on-postural-muscle-responses-to-an-unexpected-loss-of-balance
#12
Oran W Ferguson, Nadia Polskaia, Craig D Tokuno
The purpose of this study was to examine the role of foot sole somatosensory information during reactive postural control. Twenty young adults (22.0±1.4y) participated in this study. Baseline skin sensitivity from the foot sole was assessed using Semmes-Weinstein monofilaments. Postural muscle responses, in the form of electromyographic (EMG) onset latencies and amplitudes, were then obtained while participants recovered their balance while standing on a moveable platform that could translate in either the forward or backward direction...
May 25, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28551493/residential-greenness-and-adiposity-findings-from-the-uk-biobank
#13
Chinmoy Sarkar
BACKGROUND: With the rapid urbanization and prevailing obesity pandemic, the role of residential green exposures in obesity prevention has gained renewed focus. The study investigated the effects of residential green exposures on adiposity using a large and diverse population sample drawn from the UK Biobank. MATERIALS AND METHODS: This was a population based cross-sectional study of 333,183 participants aged 38-73years with individual-level data on residential greenness and built environment exposures...
May 25, 2017: Environment International
https://www.readbyqxmd.com/read/28551449/degradation-patterns-of-natural-and-synthetic-textiles-on-a-soil-surface-during-summer-and-winter-seasons-studied-using-atr-ftir-spectroscopy
#14
Maiken Ueland, Johanna M Howes, Shari L Forbes, Barbara H Stuart
Textiles are a valuable source of forensic evidence and the nature and condition of textiles collected from a crime scene can assist investigators in determining the nature of the death and aid in the identification of the victim. Until now, much of the knowledge of textile degradation in forensic contexts has been based on the visual inspection of material collected from soil environments. The purpose of the current study was to investigate the potential of a more quantitative approach to the understanding of forensic textile degradation through the application of infrared spectroscopy...
May 22, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28551410/perceptions-and-attitudes-of-community-pharmacists-toward-professional-ethics-and-ethical-dilemmas-in-the-workplace
#15
Jadranka Vuković Rodríguez, Živka Juričić
BACKGROUND: Formal training in pharmacy ethics is relatively new in Croatia, and the professional code of ethics is more than 20 years old. Very little is known about how practicing pharmacists implement ethical considerations and relevant professional guidelines in their work. OBJECTIVES: This study aimed to provide the first description of the perceptions and attitudes of Croatian community pharmacists toward ethics in pharmacy practice, how often they face certain ethical dilemmas and how they resolve them...
May 22, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/28551400/correlation-between-screening-mammography-interpretive-performance-on-a-test-set-and-performance-in-clinical-practice
#16
Diana L Miglioretti, Laura Ichikawa, Robert A Smith, Diana S M Buist, Patricia A Carney, Berta Geller, Barbara Monsees, Tracy Onega, Robert Rosenberg, Edward A Sickles, Bonnie C Yankaskas, Karla Kerlikowske
RATIONALE AND OBJECTIVES: Evidence is inconsistent about whether radiologists' interpretive performance on a screening mammography test set reflects their performance in clinical practice. This study aimed to estimate the correlation between test set and clinical performance and determine if the correlation is influenced by cancer prevalence or lesion difficulty in the test set. MATERIALS AND METHODS: This institutional review board-approved study randomized 83 radiologists from six Breast Cancer Surveillance Consortium registries to assess one of four test sets of 109 screening mammograms each; 48 radiologists completed a fifth test set of 110 mammograms 2 years later...
May 24, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28551381/a-specific-mutational-signature-associated-with-dna-8-oxoguanine-persistence-in-mutyh-defective-colorectal-cancer
#17
Alessandra Viel, Alessandro Bruselles, Ettore Meccia, Mara Fornasarig, Michele Quaia, Vincenzo Canzonieri, Eleonora Policicchio, Emanuele Damiano Urso, Marco Agostini, Maurizio Genuardi, Emanuela Lucci-Cordisco, Tiziana Venesio, Aline Martayan, Maria Grazia Diodoro, Lupe Sanchez-Mete, Vittoria Stigliano, Filomena Mazzei, Francesca Grasso, Alessandro Giuliani, Marta Baiocchi, Roberta Maestro, Giuseppe Giannini, Marco Tartaglia, Ludmil B Alexandrov, Margherita Bignami
8-Oxoguanine, a common mutagenic DNA lesion, generates G:C>T:A transversions via mispairing with adenine during DNA replication. When operating normally, the MUTYH DNA glycosylase prevents 8-oxoguanine-related mutagenesis by excising the incorporated adenine. Biallelic MUTYH mutations impair this enzymatic function and are associated with colorectal cancer (CRC) in MUTYH-Associated Polyposis (MAP) syndrome. Here, we perform whole-exome sequencing that reveals a modest mutator phenotype in MAP CRCs compared to sporadic CRC stem cell lines or bulk tumours...
April 13, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28551374/sustained-effects-of-a-psychoeducational-group-intervention-following-bariatric-surgery-follow-up-of-the-randomized-controlled-base-study
#18
Beate Wild, Katharina Hünnemeyer, Helene Sauer, Dieter Schellberg, Beat Peter Müller-Stich, Alfred Königsrainer, Rudolf Weiner, Stephan Zipfel, Wolfgang Herzog, Martin Teufel
BACKGROUND: Evidence regarding the efficacy of psychosocial interventions after bariatric surgery is rare and shows conflicting results. OBJECTIVES: The Bariatric Surgery and Education (BaSE) study aimed to assess the efficacy of a psychoeducational group intervention in patients after bariatric surgery. SETTING: The BaSE study was a randomized, controlled, multicenter clinical trial involving 117 patients who underwent bariatric surgery. Patients received either conventional postsurgical visits or, in addition, a 1-year psychoeducational group program...
April 1, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28551370/multiple-introductions-and-onward-transmission-of-hiv-1-subtype-b-strains-in-shanghai-china
#19
Xiaoshan Li, Kexin Zhu, Yile Xue, Feiran Wei, Rong Gao, Ralf Duerr, Kun Fang, Wei Li, Yue Song, Guoping Du, Wenjuan Yan, Taha Hussein Musa, You Ge, Yu Ji, Ping Zhong, Pingmin Wei
OBJECTIVE: To investigate the viral genetic evolution, spatial origins and patterns of transmission of HIV-1 subtype B in Shanghai, China. METHODS: A total of 242 Shanghai subtype B and 1519 reference pol sequences were subjected to phylogenetic inference and genetic transmission network analyses. RESULTS: Phylogenetic analyses revealed that subtype B strains circulating in Shanghai were genetically diverse and closely associated with viral sequence lineages in Beijing (76 of 242 [31...
May 24, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28551289/emergency-department-length-of-stay-and-outcome-after-ischemic-stroke
#20
Artin Minaeian, Anand Patel, Basad Essa, Richard P Goddeau, Majaz Moonis, Nils Henninger
BACKGROUND: Emergency department length of stay (ED-LOS) has been associated with worse outcomes after various medical conditions. However, there is a relative paucity of data for ischemic stroke patients. We sought to determine whether a longer ED-LOS is associated with a poor 90-day outcome after ischemic stroke. METHODS: This study is a retrospective analysis of a single-center cohort of consecutive ischemic stroke patients (n = 325). Multivariable linear and logistic regression models were constructed to determine factors independently associated with ED-LOS as well as a poor 90-day outcome (modified Rankin Scale [mRS] score >2), respectively...
May 24, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
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