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https://www.readbyqxmd.com/read/28531831/workflow-methodology-for-rat-brain-metabolome-exploration-using-nmr-lc-ms-and-gc-ms-analytical-platforms
#1
Binta Diémé, Antoine Lefèvre, Lydie Nadal-Desbarats, Laurent Galineau, Blandine Madji Hounoum, Frédéric Montigny, Hélène Blasco, Christian R Andres, Patrick Emond, Sylvie Mavel
We developed a multi-platform approach for the metabolome exploration of rat brain tissue, using liquid chromatography coupled with mass spectrometry (LC-MS), nuclear magnetic resonance spectroscopy (NMR) and gas-chromatography coupled with mass spectrometry (GC-MS). The critical steps for metabolite exploration of cerebral tissues are tissue lysis and metabolites extraction. We first evaluated the impact of freeze-drying compared to wet tissue metabolites extraction using NMR and LC-MS with a reversed phase liquid chromatography...
May 13, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28529303/social-perception-of-infertility-and-its-treatment-in-late-medieval-italy-margherita-datini-an-italian-merchant-s-wife
#2
Jong Kuk Nam
Because the perception of infertility in medieval Europe ranged from the extremely religious view of it as a malediction of God or the devil's work, to the reasonable medical conception of it as a sort of disease to treat, it is very difficult to determine the general attitudes of ordinary people towards infertility. This article seeks to elucidate the common social perception of infertility and its treatment in late medieval Europe by analyzing the case of Margherita Datini, an Italian merchant's wife who lived in the 1400s...
December 2016: Ŭi Sahak
https://www.readbyqxmd.com/read/28529234/-in-utter-fearlessness-of-the-reigning-disease-imagined-immunities-and-the-outbreak-narratives-of-charles-brockden-brown
#3
Nicholas E Miller
With an increased focus on the intersection of literature and medicine, contagion has become something of a scholarly buzzword in early American studies: it serves metaphorically to demarcate the postcolonial other, demonstrates the transmissibility of revolutionary rhetoric, highlights the instability of republican government, and embodies fears of racial mixture. In this essay, I shift the emphasis from a discourse of contagion (often associated with a fear of the foreign) to a discourse of immunity (a fear associated with foreign immunities) in order to demonstrate a more affirmative biopolitics in Charles Brockden Brown's 1790s outbreak narratives...
2017: Literature and Medicine
https://www.readbyqxmd.com/read/28529231/alzheimer-s-disease-metaphors-as-mirror-and-lens-to-the-stigma-of-dementia
#4
Martina Zimmermann
This essay gives an overview of the metaphors that patients in comparison to caregivers employ to conceptualize their experience with the chronic degenerative, cognitive, and incurable aspects of Alzheimer's disease. It explores how the images (such as the journey, darkness, the death sentence, and torture) relate to the narration of cognitive decline and memory loss, and how these personal accounts negotiate with the culturally dominant dementia narrative that centers on the patient's passivity and dependence and is, usually, found in caregiver stories...
2017: Literature and Medicine
https://www.readbyqxmd.com/read/28529228/-the-absence-doubled-photo-poetic-narratives-of-prophylactic-mastectomy
#5
Stella Bolaki
This essay considers Clare Best's poetic sequence Self-portrait without Breasts (2011) and her collaboration with photographer Laura Stevens, which explore preventive surgery and questions of genetics/hereditary breast cancer. In an era when risk and cosmetic reconstruction guide treatment and the development of new breast cancer subjects, Best reclaims the "flat simple scarred chest with no extras." I situate her poems in the context of statistics and the neoliberal postfeminist subject as well as in a poetic tradition about the post-mastectomy body as landscape...
2017: Literature and Medicine
https://www.readbyqxmd.com/read/28523439/magnetic-resonance-imaging-of-painful-swollen-legs-in-the-emergency-department-a-pictorial-essay
#6
REVIEW
Ashish Chawla, Niraj Dubey, Kian Ming Chew, Dinesh Singh, Vishal Gaikwad, Wilfred Cg Peh
Patients presenting with a painful swollen leg are not infrequently encountered at the emergency department and can pose a diagnostic dilemma for attending physicians. The potential causes of leg pain and swelling include trauma, infection, inflammation, and neurogenic, vascular, and iatrogenic conditions; with magnetic resonance imaging (MRI) being an important tool in evaluation. We describe the MRI features of various conditions causing painful swollen legs. We also discuss the differential diagnosis and the useful clinical and laboratory findings that radiologists should be aware of, in order to arrive at an accurate diagnosis...
May 18, 2017: Emergency Radiology
https://www.readbyqxmd.com/read/28522760/on-the-existence-of-a-central-respiratory-oxygen-sensor
#7
Alexander V Gourine, Gregory D Funk
A commonly held view that dominates both the scientific and educational literature is that in terrestrial mammals the central nervous system lacks a physiological hypoxia sensor capable of triggering increases in lung ventilation in response to decreases in PO2 of the brain parenchyma. Indeed, a normocapnic hypoxic ventilatory response has never been observed in humans following bilateral resection of the carotid bodies. In contrast, almost complete or partial recovery of the hypoxic ventilatory response after denervation/removal of the peripheral respiratory oxygen chemoreceptors has been demonstrated in many experimental animals when assessed in an awake state...
May 18, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28516346/site-sector-scope-mapping-the-epistemological-landscape-of-health-humanities
#8
Andrea Charise
This essay presents a critical appraisal of the current state of baccalaureate Health Humanities, with a special focus on the contextual differences currently influencing the implementation of this field in Canada and, to a lesser extent, the United States and United Kingdom. I argue that the epistemological bedrock of Health Humanities goes beyond that generated by its written texts to include three external factors that are especially pertinent to undergraduate education: site (the setting of Health Humanities education), sector (the disciplinary eligibility for funding) and scope (the critical engagement with a program's local context alongside an emergent "core" of Health Humanities knowledge, learning, and practice)...
May 17, 2017: Journal of Medical Humanities
https://www.readbyqxmd.com/read/28515965/anatomic-variations-of-the-right-portal-vein-prevalence-imaging-features-and-implications-for-successful-transjugular-intrahepatic-portosystemic-shunt-creation
#9
Senthil S Gunasekaran, Ron C Gaba
Given the widespread use of transjugular intrahepatic portosystemic shunt (TIPS) creation for the treatment of portal hypertensive complications, a working knowledge of portal venous anatomy is critical for interventional radiologists. The right portal vein - which is most commonly accessed during TIPS - is subject to various anatomic variants that may potentially impact procedure success. This pictorial essay characterizes the anatomic patterns of the right portal vein branching in terms of type and frequency based on case series review...
2017: Journal of Clinical Imaging Science
https://www.readbyqxmd.com/read/28511550/ct-features-in-surgically-proven-cases-of-ovarian-torsion-a-pictorial-review
#10
Sunita Dhanda, Swee Tian Quek, Ying Ting Mok, Clement Yong Hsiang Rong, Yuik Sing Eric Ting, Pooja Jagmohan, Bernard Wee
Ovarian torsion is a surgical emergency characterized by a partial or complete rotation of the ovarian vascular pedicle, causing obstruction to venous outflow followed by arterial inflow. Clinically, ovarian torsion frequently mimics other causes of acute pelvic pain such as appendicitis, diverticulitis, renal colic etc. Ultrasonography (US) is the first line imaging modality of choice for evaluation of ovarian torsion. MRI is useful as a problem solving tool in patients with equivocal or non diagnostic US studies...
May 16, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28510503/are-we-becoming-inaccessible-caregivers
#11
Jason J Han
This essay is a personal reflection of my mindset as a caregiver, and how that has evolved throughout my training.
May 16, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28508252/anatomical-variants-in-prostate-artery-embolization-a-pictorial-essay
#12
Francisco Cesar Carnevale, Guilherme Rebello Soares, Andre Moreira de Assis, Airton Mota Moreira, Sardis Honoria Harward, Giovanni Guido Cerri
Prostate artery embolization (PAE) has emerged as a new treatment option for patients with symptomatic benign prostatic hyperplasia. The main challenges related to this procedure are navigating arteries with atherosclerosis and anatomical variations, and the potential risk of non-target embolization to pelvic structures due to the presence of collateral shunts and reflux of microparticles. Knowledge of classical vascular anatomy and the most common variations is essential for safe embolization, good clinical practice, and optimal outcomes...
May 15, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28504329/rediscovering-the-ritual-technology-of-the-placebo-effect-in-analytical-psychology
#13
Erik Goodwyn
Technology, viewed more generally, is a collection of skills and methods that are used to accomplish an objective of some kind. Modernity has produced many kinds of ever-expanding new technologies, but it is also evident that technologies can be lost or fall out of use. A cross-cultural survey of ritual reveals a rather startling observation: that while developed nations often exceed other cultures in terms of material technology, they often pale by comparison in their use of ritual technology. In this essay we will see how ritual is a powerful sort of technology that developed nations have mostly allowed to drift out of regular, vigorous use, despite its numerous psychological and biological effects...
June 2017: Journal of Analytical Psychology
https://www.readbyqxmd.com/read/28501142/charcot-past-and-present
#14
REVIEW
C G Goetz
Jean-Martin Charcot (1825-1893) was the preeminent neurologist of the nineteenth century. Several of his major contributions remain fully relevant to contemporary neurology, and this essay highlights three areas of particular importance to the modern neurologist: the anatomo-clinical method that Charcot developed as the anchor of neurological study; the integration of new scientific discoveries from other fields as a core strategy for neurological advancement; and the role of heredity as the fundamental etiological focus to the understanding of the pathogenesis of primary neurological disorders...
May 10, 2017: Revue Neurologique
https://www.readbyqxmd.com/read/28499324/ascariasis-imaging-pictorial-essay
#15
Christoph F Dietrich, Malay Sharma, Nitin Chaubal, Yi Dong, Xin-Wu Cui, Markus Schindler-Piontek, Joachim Richter, Maija Radzina, Fayez Sandouk, Torsten Kucharzik, Dagmar Schreiber-Dietrich
Ascariasis is not widespread in Europe, and the knowledge on how to diagnose and treat the disease is limited to some specialists. On the other hand, clinicians are facing an increasing number of immigrants from high-prevalence countries and are, therefore, challenged to update in this field of infectious diseases. Here we present current knowledge on this infection in 2 parts. The first part discusses clinical features and hot topics in ascariasis, and the second part presents imaging features of ascariasis as a pictorial essay...
May 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/28497705/circulating-biomedical-images-bodies-and-chromosomes-in-the-post-eugenic-era
#16
María Jesús Santesmases
This essay presents the early days of human cytogenetics, from the late 1950s until the mid 1970s, as a historical series of images. I propose a chronology moving from photographs of bodies to chromosome sets, to be joined by ultrasound images, which provided a return to bodies, by then focused on the unborn. Images carried ontological significance and, as I will argue, are principal characters in the history of human cytogenetics. Inspired by the historiography of heredity and genetics, studies on visual cultures, the conceptualization of circulation, and the sociology of pregnancy, I suggest that cytogenetics, through its focus on pregnancy, pregnant women, and their offspring, found strategic living materials that stabilized human chromosome studies as a biomedical, post-eugenics practice...
May 1, 2017: History of Science; An Annual Review of Literature, Research and Teaching
https://www.readbyqxmd.com/read/28497406/assessing-the-gap-in-female-authorship-in-the-journal-emergency-radiology-trends-over-a-20-year-period
#17
Kristopher McKenzie, Milita Ramonas, Michael Patlas, Douglas S Katz
PURPOSE: To examine trends in female authorship in the journal Emergency Radiology from January 1994 to December 2014. METHODS: We obtained institutional review board approval for our study. We retrospectively reviewed a total of 1617 articles published in the journal Emergency Radiology over a 20-year period. Original articles, case reports, review articles, and pictorial essays were included. The first and last position author's gender was categorized as female or male...
May 12, 2017: Emergency Radiology
https://www.readbyqxmd.com/read/28493758/lying-because-we-care-compassion-increases-prosocial-lying
#18
Matthew J Lupoli, Lily Jampol, Christopher Oveis
Prosocial lies, or lies intended to benefit others, are ubiquitous behaviors that have important social and economic consequences. Though emotions play a central role in many forms of prosocial behavior, no work has investigated how emotions influence behavior when one has the opportunity to tell a prosocial lie-a situation that presents a conflict between two prosocial ethics: lying to prevent harm to another, and honesty, which might also provide benefits to the target of the lie. Here, we examine whether the emotion of compassion influences prosocial lying, and find that compassion causally increases and positively predicts prosocial lying...
May 11, 2017: Journal of Experimental Psychology. General
https://www.readbyqxmd.com/read/28492213/psychiatry-outside-the-framework-of-empiricism
#19
Celestine Okorome Mume
Science is interested in whatever that is empirical and objective. Any claim that cannot be objectively demonstrated has no place in science, because the subject does not deviate from the role, which it has set out to play in the life of mankind. Psychiatry, as a scientific discipline, plays along these basic principles. In the etiology, symptomatology, and management of psychiatric disorders, the biopsychosocial model recognizes the role of biological, psychological, and social factors. This essay views psychiatry from the biopsychosocial perspective and asserts that certain elements, which may not be readily and empirically verifiable, are important in the practice of psychiatry...
January 2017: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28490854/effects-of-sequences-of-cognitions-on-group-performance-over-time
#20
Inge Molenaar, Ming Ming Chiu
Extending past research showing that sequences of low cognitions (low-level processing of information) and high cognitions (high-level processing of information through questions and elaborations) influence the likelihoods of subsequent high and low cognitions, this study examines whether sequences of cognitions are related to group performance over time; 54 primary school students (18 triads) discussed and wrote an essay about living in another country (32,375 turns of talk). Content analysis and statistical discourse analysis showed that within each lesson, groups with more low cognitions or more sequences of low cognition followed by high cognition added more essay words...
April 2017: Small Group Research
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