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https://www.readbyqxmd.com/read/28643798/topical-administration-of-esculetin-as-a-potential-therapy-for-experimental-dry-eye-syndrome
#1
D Jiang, X Liu, J Hu
PurposeIn this study, we investigated the therapeutic effects of topical Esculetin for dry eye rabbits through the ocular tests, inflammatory factor levels and specific phosphorylated protein expressions of ERK1/2 singnal pathway.Patients and methodsThirty-two healthy adult male New Zealand white rabbits were chosen for the study. DES models were established after removing of the main lacrimal gland, Harderian gland and nictitating membrane in the left eyes and randomly divided into group DES control, group CsA, group Esculetin and group Esculetin combined with CsA (C&E), meanwhile the right eyes served as group Normal control...
June 23, 2017: Eye
https://www.readbyqxmd.com/read/28639739/philosophical-aesthetics-and-cognitive-science
#2
REVIEW
Aaron Meskin, Jon Robson, Anna Ichino, Kris Goffin, Annelies Monseré
Philosophical aesthetics is the branch of philosophy which explores issues having to do with art, beauty, and related phenomena. Philosophers have often been skeptical about the place of empirical investigation in aesthetics. However, in recent years many philosophical aestheticians have turned to cognitive science to enrich their understanding of their subject matter. Cognitive scientists have, in turn, been inspired by work in philosophical aesthetics. This essay focuses on a representative subset of the areas in which there has been fruitful dialog between philosophical aestheticians and cognitive scientists...
June 22, 2017: Wiley Interdisciplinary Reviews. Cognitive Science
https://www.readbyqxmd.com/read/28638696/basic-radiological-assessment-of-synovial-diseases-a-pictorial-essay
#3
REVIEW
Aynur Turan, Pınar Çeltikçi, Abdurrahman Tufan, Mehmet Akif Öztürk
The synovium is a specialized tissue lining the synovial joints, bursae, and tendon sheaths of the body. It is affected by various localized or systemic disorders. Synovial diseases can be classified as inflammatory, infectious, degenerative, traumatic, hemorrhagic, and neoplastic. Damage in other intraarticular structures, particularly cartilages, generally occurs as a part of pathologic processes involving the synovium, leading to irreversible joint destruction. Imaging has an essential role in the early detection of synovial diseases prior to irreversible joint damage...
June 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28638360/sequential-effects-in-essay-ratings-evidence-of-assimilation-effects-using-cross-classified-models
#4
Haiyan Zhao, Björn Andersson, Boliang Guo, Tao Xin
Writing assessments are an indispensable part of most language competency tests. In our research, we used cross-classified models to study rater effects in the real essay rating process of a large-scale, high-stakes educational examination administered in China in 2011. Generally, four cross-classified models are suggested for investigation of rater effects: (1) the existence of sequential effects, (2) the direction of the sequential effects, and (3) differences in raters by their individual characteristics...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28634769/decision-making-capacity-and-unusual-beliefs-two-contentious-cases-australasian-association-of-bioethics-and-health-law-john-mcphee-law-student-essay-prize-2016
#5
Brent Hyslop
Decision-making capacity is a vital concept in law, ethics, and clinical practice. Two legal cases where capacity literally had life and death significance are NHS Trust v Ms T [2004] and Kings College Hospital v C [2015]. These cases share another feature: unusual beliefs. This essay will critically assess the concept of capacity, particularly in relation to the unusual beliefs in these cases. Firstly, the interface between capacity and unusual beliefs will be examined. This will show that the "using and weighing of information" is the pivotal element in assessment...
June 20, 2017: Journal of Bioethical Inquiry
https://www.readbyqxmd.com/read/28634766/political-minimalism-and-social-debates-the-case-of-human-enhancement-technologies
#6
Javier Rodríguez-Alcázar
A faulty understanding of the relationship between morality and politics encumbers many contemporary debates on human enhancement. As a result, some ethical reflections on enhancement undervalue its social dimensions, while some social approaches to the topic lack normative import. In this essay, I use my own conception of the relationship between ethics and politics, which I call "political minimalism," in order to support and strengthen the existing social perspectives on human-enhancement technologies.
June 20, 2017: Journal of Bioethical Inquiry
https://www.readbyqxmd.com/read/28634530/the-role-of-medical-education-in-the-development-of-the-scientific-practice-of-medicine
#7
Lucien Cardinal, Alan Kaell
The authors describe the important role of medical schools and graduate medical education programs (residencies) in relationship to the advances in Medicine witnessed during the twentieth century; diagnosis, prognosis and treatment were revolutionized. This historical essay details the evolution of the education system and the successful struggle to introduce a uniform, science-based curriculum and bedside education. The result was successive generations of soundly educated physicians prepared with a broad knowledge in science, an understanding of laboratory methods and the ability to practice medicine at the bedside...
January 2017: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/28634440/cysteines-as-redox-molecular-switches-and-targets-of-disease
#8
REVIEW
Annamaria Fra, Edgar D Yoboue, Roberto Sitia
Thiol groups can undergo numerous modifications, making cysteine a unique molecular switch. Cysteine plays structural and regulatory roles as part of proteins or glutathione, contributing to maintain redox homeostasis and regulate signaling within and amongst cells. Not surprisingly therefore, cysteines are associated with many hereditary and acquired diseases. Mutations in the primary protein sequence (gain or loss of a cysteine) are most frequent in membrane and secretory proteins, correlating with the key roles of disulfide bonds...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28631181/glaucoma-awareness-amongst-glaucoma-patients-seeking-a-second-opinion
#9
Devindra Sood, Shivam Sood, Ishaana Sood, Dinesh Kumar, Rajeev Sood, Narender Nath Sood
PURPOSE: The aim of the study was to assess level of glaucoma awareness amongst glaucoma patients by studying characteristics amongst urban and rural glaucoma populations in North India. METHODS: A questionnaire was designed and administered after appropriate validation amongst patients to identify determinants of glaucoma awareness. Trained personnel delivered the 11 questions to 1506 patients, aged 18 and above through random sampling. The questionnaire evaluated source of awareness, education, gender, location and age on the level of awareness of glaucoma...
June 19, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28627993/essays-on-rising-mortality-in-england-and-wales-a-medline-search-is-not-infallible
#10
Rodney P Jones
No abstract text is available yet for this article.
June 2017: Journal of the Royal Society of Medicine
https://www.readbyqxmd.com/read/28627248/methodological-challenges-involved-in-compiling-the-nahua-pharmacopeia
#11
Paula De Vos
Recent work in the history of science has questioned the Eurocentric nature of the field and sought to include a more global approach that would serve to displace center-periphery models in favor of approaches that take seriously local knowledge production. Historians of Iberian colonial science have taken up this approach, which involves reliance on indigenous knowledge traditions of the Americas. These traditions present a number of challenges to modern researchers, including availability and reliability of source material, issues of translation and identification, and lack of systematization...
June 1, 2017: History of Science; An Annual Review of Literature, Research and Teaching
https://www.readbyqxmd.com/read/28624970/cardiovascular-implantable-electronic-devices-a-review-of-the-dangers-and-difficulties-in-mr-scanning-and-attempts-to-improve-safety
#12
REVIEW
Pei Ghim Poh, Charlene Liew, Colin Yeo, Le Roy Chong, Andrew Tan, Angeline Poh
An increasing number of patients are being treated with cardiovascular implantable electronic devices (CIEDs), many of which are MR conditional. There is a lack of literature on the safe scanning of MR conditional CIEDs. This review article discusses MR imaging safety in patients with implanted CIEDs. Guidelines on safe use and indications of imaging patients with MR conditional CIEDs are described, followed by a pictorial essay of the radiographic features of these devices. We also discuss the challenges of monitoring the patient in the MR environment, advances in MRI conditional imaging of devices, availability, limitations and workflow including vendor-specific and other collaborative efforts to simplify the scanning process...
June 17, 2017: Insights Into Imaging
https://www.readbyqxmd.com/read/28623440/the-impact-of-baccalaureate-medical-humanities-on-subsequent-medical-training-and-practice-a-physician-educator-s-perspective
#13
Lauren Barron
This reflective essay is an attempt to organize trends in feedback I have observed during ten years of coursework, conversations, and correspondence with former students associated with the Medical Humanities Program at Baylor University. Over the years, recurrent themes arise when speaking with alumni about whether and how their medical humanities experience intersects with their current training. I have identified five particular domains in which baccalaureate medical humanities training affects students' subsequent healthcare professions training and practice: context and complementarity, clinical relevance, reflective practice, professional preparedness and vocational calling...
June 17, 2017: Journal of Medical Humanities
https://www.readbyqxmd.com/read/28623439/proposing-a-health-humanities-minor-some-lessons
#14
Virginia Bucurel Engholm, Damon Boria
For those interested in developing baccalaureate programs in health humanities, this essay draws on our experience of developing a minor in health humanities to share insights on what to expect, strategies that work well, and how to deal with obstacles. These insights range from how to explain the concept of health humanities to stakeholders (faculty, administrators, and community partners) to how to decide where to house a health humanities program. We share our insights in a way that promises to translate well to different institutional contexts...
June 16, 2017: Journal of Medical Humanities
https://www.readbyqxmd.com/read/28621629/endoscopic-endonasal-odontoid-resection-with-real-time-intraoperative-image-guided-computed-tomography-report-of-4-cases
#15
Harminder Singh, Sarang Rote, Ajit Jada, Evan D Bander, Gustavo J Almodovar-Mercado, Walid I Essayed, Roger Härtl, Vijay K Anand, Theodore H Schwartz, Jeffrey P Greenfield
The authors present 4 cases in which they used intraoperative CT (iCT) scanning to provide real-time image guidance during endonasal odontoid resection. While intraoperative CT has previously been used as a confirmatory test after resection, to the authors' knowledge this is the first time it has been used to provide real-time image guidance during endonasal odontoid resection. The operating room setup, as well as the advantages and pitfalls of this approach, are discussed. A mobile intraoperative CT scanner was used in conjunction with real-time craniospinal neuronavigation in 4 patients who underwent endoscopic endonasal odontoidectomy for basilar invagination...
June 16, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28620977/2016-ase-undergraduate-essay-competition-candidate-information
#16
Alice Chen
The aim of this review is to discuss the role of medicaments and materials used in teeth undergoing root canal treatment and how they affect the overall prognosis of root canal treated teeth. Irrigants, medicaments and materials play a vital role in RCT. They reduce the overall microbial load within the root canal system, help reduce inter-appointment pain, and induce apexification during RCT of permanent teeth with immature apices. In addition, they also help create a hermetic coronal and periradicular seal to entomb any residual microorganisms within the canals and prevent future ingress of contaminants into the root canal system and subsequent reinfection...
June 15, 2017: Australian Endodontic Journal: the Journal of the Australian Society of Endodontology Inc
https://www.readbyqxmd.com/read/28617582/liquid-crystal-based-immunosensor-for-diagnosis-of-tuberculosis-in-clinical-specimens
#17
Hyeong Jin Kim, Jinseob Rim, Chang-Hyun Jang
Tuberculosis (TB) is a serious global health problem, although it is easily preventable and curable. The prevalence of TB is caused by a lack of simple, rapid, cheap, and effective TB diagnostic tests. In this study, we have established a novel liquid crystal (LC)-based immunosensor to diagnose TB in clinical specimens. The clinical serum samples were incubated on a TB antigen-immobilized substrate, and their optical LC responses were observed using a polarized light microscope. Specific binding of anti-TB antibodies to the TB antigen-immobilized surface only occurred in clinical specimens from TB patients, inducing the disruption of the orientation of LCs...
June 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28616787/subtle-radiographic-signs-of-hamate-body-fracture-a-diagnosis-not-to-miss-in-the-emergency-department
#18
Nathan D Cecava, Mary F Finn, Liem T Mansfield
Hamate fractures are estimated to represent 1.7% of all carpal fractures and can occur at the hamulus (hook) or hamate body depending on mechanism of injury. Fractures of the hamate body can be exceedingly difficult to identify on standard wrist and hand radiographs in the emergency department. If the diagnosis is missed in the emergency department, orthopedic referral is often delayed. This can result in lasting functional disability for the patient, as these fractures have a propensity to destabilize the fourth and fifth carpometacarpal (CMC) joints...
June 14, 2017: Emergency Radiology
https://www.readbyqxmd.com/read/28614496/the-republic-in-crisis-and-future-possibilities
#19
José Maurício Domingues
This text gives a brief reconstruction of the process of impeachment of Brazil's President Dilma Rousseff, which was a 'coup' effected through parliament, and situates it at the end of three periods of politics in the Brazilian republic: the first, broader, and democratizing; the second, the age of the PT (Workers' Party) as the force with the hegemony on the left; and the third, shorter, the cycle of its governments. Together, these phases constitute a crisis of the republic, although not a rupture of the country's institutional structure, nor a 'State of Exception'...
June 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28611719/hablo-ingl%C3%A3-s-y-espa%C3%A3-ol-cultural-self-schemas-as-a-function-of-language
#20
Gloriana Rodríguez-Arauz, Nairán Ramírez-Esparza, Norma Pérez-Brena, Ryan L Boyd
Research has demonstrated that bilingual individuals experience a "double personality," which allows them to shift their self-schemas when they are primed with different language modes. In this study, we examine whether self-schemas change in Mexican-American (N = 193) bilinguals living in the U.S. when they provide open-ended personality self-descriptions in both English and Spanish. We used the Meaning Extraction Helper (MEH) software to extract the most salient self-schemas that influence individuals' self-defining process...
2017: Frontiers in Psychology
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