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https://www.readbyqxmd.com/read/29791267/jealousy-as-a-driving-force-for-murder
#1
Nicolas Evzonas
This essay draws on analytic concepts and artistic examples in order to explore murder as the ultimate fate of jealousy. The paper first explores two seemingly neurotic forms of possessive fury that result in a crime of passion. Both cases probe the criminal potential of a supposedly normal subject and question the frontiers of narcissism and self-love, while discussing gender stereotypes. The author then examines criminal jealousy from the vantage point of the specular stakes at play: the enamoration of the double pervaded with aggressiveness that stems from the pre-oedipal fraternal complex and leads to outbursts of psychotic allure...
June 2018: Psychoanalytic Review
https://www.readbyqxmd.com/read/29790003/rationalizing-the-path-to-a-universal-graft-recipient
#2
REVIEW
Melvin Cohn
The goal of this essay is to take the reader through the logic that would predict universal graft acceptance. The story begins with what we learned from an experiment performed 65 years ago and develops that information in greater depth. The pathway of the analysis leads to the conclusion that controlling the immune system at the level of the T-helper would be the best way to approach a general solution to the problem of graft acceptance.
May 22, 2018: Immunologic Research
https://www.readbyqxmd.com/read/29789307/overcoming-overuse-the-way-forward-is-not-standing-still-an-essay-by-steven-woloshin-and-lisa-m-schwartz
#3
Steven Woloshin, Lisa M Schwartz
No abstract text is available yet for this article.
May 22, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29786940/glycoinformatics-bridging-isolated-islands-in-the-sea-of-data
#4
Ksenia S Egorova, Philip V Toukach
Glycoinformatics is a young scientific branch, which assists the scientific community in carbohydrate research. In spite of fundamental roles of glycans in living organisms, the informatization of the field is significantly hindered by the lack of standards, data indices, protocols and tools widely recognized by researchers and publishers. The connection of the existing glycoinformatics projects with each other and with global life-science projects is far from complete. Moreover, in contrast to genes and proteins, there is no obligatory unique identifier for each natural carbohydrate structure...
May 22, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29783736/revisiting-cd28-superagonist-tgn1412-as-potential-therapeutic-for-pediatric-b-cell-leukemia-a-review
#5
REVIEW
Katelyn E Brown
Pediatric acute lymphoblastic leukemia (ALL) represents the most common pediatric cancer diagnosis, with numbers rising gradually every year. This paper proposes a novel therapeutic agent for pediatric ALL on the basis of a failed clinical drug trial in 2006. TGN1412 was a promising therapeutic agent that yielded outstanding results in both in vitro studies and animal trials. It is a CD28 superagonist monoclonal antibody that activates T regulatory (TReg ) cells in the absence of costimulation of the T cell receptor (TCR) by an antigen-presenting cell...
May 19, 2018: Diseases (Basel)
https://www.readbyqxmd.com/read/29779780/on-sunspots-click-science-and-molecular-iconography
#6
Igor Mokrousov
CRISPR-spoligotyping and MIRU-VNTR typing, SITVIT_WEB and MIRU-VNTRplus are the methods and online resources most widely used for Mycobacterium tuberculosis genotype family assignment and clustering analysis. They have been proven invaluable for molecular epidemiological studies of this important human pathogen in setting up the terminology and classification framework. However, they are inherently limited by insufficient knowledge of evolution of the targeted genome loci (especially, CRISPR). The situation is aggravated by the dogmatic, iconographic perception of these increasingly user-friendly online tools...
May 2018: Tuberculosis
https://www.readbyqxmd.com/read/29770899/response-bias-in-research-on-religion-spirituality-and-mental-health-a-critical-review-of-the-literature-and-methodological-recommendations
#7
Everton de Oliveira Maraldi
Although a significant body of research supports the psychological benefits of religion and spirituality, more investigations are needed to understand the mechanisms by which they impact mental health. While some studies suggest a causal direct influence, the findings may still be subject to unmeasured factors and confounders. Despite compelling empirical support for the dangers of response bias, this has been a widely neglected topic in mental health research. The aim of this essay is to critically examine the literature addressing the role of response bias in the relationship between religion, spirituality and mental health...
May 16, 2018: Journal of Religion and Health
https://www.readbyqxmd.com/read/29769239/hypertriglyceridemia-and-cardiovascular-risk-a-cautionary-note-about-metabolic-confounding
#8
Allan D Sniderman, Patrick Couture, Seth B Martin, Jacqueline DeGraaf, Patrick R Lawler, William C Cromwell, John T Wilkins, George Thanassoulis
Triglycerides are the conventional tool to measure very low-density lipoproteins (VLDL) whereas low-density lipoprotein cholesterol (LDL-C) is the conventional tool to measure low-density lipoproteins (LDL). Multiple epidemiological studies, including a series of genetically based analyses, have demonstrated cardiovascular risk is related to triglycerides independently of LDL-C and this has led to a series of new therapeutic agents designed specifically to reduce plasma triglycerides. The triglyceride hypothesis posits that increased levels of triglycerides increase cardiovascular risk and decreasing plasma triglycerides decreases cardiovascular risk...
May 16, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29768429/virtual-reality-method-to-analyze-visual-recognition-in-mice
#9
Brent Kevin Young, Jayden Nicole Brennan, Ping Wang, Ning Tian
Behavioral tests have been extensively used to measure the visual function of mice. To determine how precisely mice perceive certain visual cues, it is necessary to have a quantifiable measurement of their behavioral responses. Recently, virtual reality tests have been utilized for a variety of purposes, from analyzing hippocampal cell functionality to identifying visual acuity. Despite the widespread use of these tests, the training requirement for the recognition of a variety of different visual targets, and the performance of the behavioral tests has not been thoroughly characterized...
2018: PloS One
https://www.readbyqxmd.com/read/29766978/wilder-penfield-the-second-career-with-other-essays-and-addresses
#10
Sunil Pandya
No abstract text is available yet for this article.
May 2018: Neurology India
https://www.readbyqxmd.com/read/29765006/exosomes-and-extracellular-vesicles-the-path-forward
#11
REVIEW
Philip D Stahl, Graça Raposo
Over the course of the past several decades, the concept that extracellular vesicles, exosomes and microvesicles, operate as cellular "housekeepers" and as agents for communication between and among cells and tissues, has emerged into one of the most promising yet vexing problems facing the biomedical community. Already, extracellular vesicles from biological fluids are being used for diagnostic purposes and hopes abound for their use as therapeutic agents. However, the most basic mechanistic questions surrounding their biogenesis and function in cellular and tissue homeostasis remain largely unexplored...
May 15, 2018: Essays in Biochemistry
https://www.readbyqxmd.com/read/29764348/james-parkinson-s-em-essay-on-the-shaking-palsy-em-1817-2017
#12
Nadeem Toodayan
No abstract text is available yet for this article.
May 21, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/29763392/should-family-be-permitted-in-a-trauma-bay
#13
Matthew Traylor
This essay explores how some of the arguments advanced for and against family presence during cardiopulmonary resuscitation might apply to the question of whether family should be permitted in the trauma bay. While the first section suggests that many of the proposed benefits might apply to family presence during trauma resuscitations, the second section contends that family presence in the trauma bay could detract from the quality of patient care, violate patient privacy, and be psychologically damaging for the witnessing family...
May 1, 2018: AMA Journal of Ethics
https://www.readbyqxmd.com/read/29760698/mechanisms-of-cryptococcus-neoformans-mediated-host-damage
#14
REVIEW
Arturo Casadevall, Carolina Coelho, Alexandre Alanio
Cryptococcus neoformans is not usually considered a cytotoxic fungal pathogen but there is considerable evidence that this microbe can damage host cells and tissues. In this essay, we review the evidence that C. neoformans damages host cells and note that the mechanisms involved are diverse. We consider C. neoformans -mediated host damage at the molecular, cellular, tissue, and organism level. Direct mechanisms of cytotoxicity include lytic exocytosis, organelle dysfunction, phagolysosomal membrane damage, and cytoskeletal alterations...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29760032/white-privilege-in-a-white-coat-how-racism-shaped-my-medical-education
#15
Max J Romano
In this essay, I reflect on some of the ways racial privilege influenced my experience as a white physician in training. While white Americans often think of "racism" as a social construct primarily affecting people of color, "racism" is a system of both racial disadvantage as well as reciprocal racial advantage. Medical professionals are increasingly aware of how social determinants of health lead to important health disparities, however white physicians seldom ask how their own racial privilege reinforces a white supremacist culture and what effects this may have on our patients' health...
May 2018: Annals of Family Medicine
https://www.readbyqxmd.com/read/29756084/reconsidering-the-international-association-for-the-study-of-pain-definition-of-pain
#16
REVIEW
Milton Cohen, John Quintner, Simon van Rysewyk
Introduction: The definition of pain promulgated by the International Association for the Study of Pain (IASP) is widely accepted as a pragmatic characterisation of that human experience. Although the Notes that accompany it characterise pain as "always subjective," the IASP definition itself fails to sufficiently integrate phenomenological aspects of pain. Methods: This essay reviews the historical development of the IASP definition, and the commentaries and suggested modifications to it over almost 40 years...
March 2018: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/29755064/john-robert-seeley-i-natural-religion-i-and-the-victorian-conflict-between-science-and-religion
#17
Ian Hesketh
This essay examines the publishing and reception of J. R. Seeley's Natural Religion (1882), a book that sought to bring about a reconciliation between science and religion. While Natural Religion has long been overlooked, it is argued that its reception gives us insight into changing views about the relationship between science and religion in the late Victorian period. The essay also explores how the reception of the book was conditioned by its bibliographic lineage as it was signed not by Seeley, but "by the Author of Ecce Homo...
2018: Journal of the History of Ideas
https://www.readbyqxmd.com/read/29755063/marx-and-the-kabbalah-aaron-shemuel-lieberman-s-materialist-interpretation-of-jewish-history
#18
Eliyahu Stern
This essay addresses the reception of Karl Marx's writings among Russian Jewish revolutionaries in the 1870s. It explores the way Aaron Shemuel Lieberman (1843-1880), known as "the father of Jewish socialism," interpreted Marx through a kabbalistic prism. It argues that Jews were attracted to Marx in part because of the overlaps between historical materialism and certain strands of the kabbalistic tradition. It also sheds light on the early reception of Marx and the way his theory of revolution was reinterpreted to reflect the unique socio-economic conditions of the Russian Empire...
2018: Journal of the History of Ideas
https://www.readbyqxmd.com/read/29751812/negotiating-health-patients-and-guardians-perspective-on-failed-patient-professional-interactions-in-the-context-of-the-swedish-health-care-system
#19
Roland Koch, Stefanie Joos, Elsa-Lena Ryding
BACKGROUND: Sweden has a largely tax-funded health care system that aims at providing equal access for everyone. However, the individual's perception and experience of the health care system remains a relevant topic for researchers. The aim of this study is to learn the patient's perspective on how patients and professionals negotiate in the social context of the Swedish health care system. METHODS: Eight essays that had spontaneously been contributed to a medical writing contest were analyzed using narrative methods...
May 11, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29749847/how-to-identify-the-research-abilities-that-instructors-anticipate-students-will-develop-in-a-biochemistry-course-based-undergraduate-research-experience-cure
#20
Stefan Mark Irby, Nancy J Pelaez, Trevor R Anderson
Course-based undergraduate research experiences (CUREs) have been described in a range of educational contexts. Although various anticipated learning outcomes (ALOs) have been proposed, processes for identifying them may not be rigorous or well documented, which can lead to inappropriate assessment and speculation about what students actually learn from CUREs. In this essay, we offer a user-friendly and rigorous approach based on evidence and an easy process to identify ALOs, namely, a five-step Process for Identifying Course-Based Undergraduate Research Abilities (PICURA), consisting of a content analysis, an open-ended survey, an interview, an alignment check, and a two-tiered Likert survey...
June 2018: CBE Life Sciences Education
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