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https://www.readbyqxmd.com/read/28988370/morphologic-characteristics-of-macroscopic-peritoneal-finding-in-patients-with-peritoneal-dialysis
#1
Chieko Hamada, Hirotaka Nakamoto, Yusuke Suzuki
Peritoneal dialysis (PD) has been an attractive treatment for end-stage kidney disease. Long-term exposure to the PD solution creates functional and morphological alterations, and these alterations diminish the efficacy of PD. It is important to establish an evaluation of the changes in PD patients and strategies for the prevention of PD damage and encapsulating peritoneal sclerosis (EPS). We determined the relationship between clinical findings and macroscopic morphological findings by laparoscopy in patients receiving PD...
October 7, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28970363/comparison-of-change-in-peritoneal-function-in-patients-on-continuous-ambulatory-pd-vs-automated-pd
#2
Nasreen Samad, Stanley Fan
BACKGROUND: Patients on automated peritoneal dialysis (APD) may have greater exposure to glucose in the PD fluid than those on continuous ambulatory PD (CAPD). If this causes long-term damage to the peritoneal membrane, it will have implications for a patient's choice of modality. METHODS: Membrane function of long-term APD or CAPD patients was followed prospectively. The data were collected from electronic patient records in our unit from 2000 to 2014. The rate of change in membrane transport status (D/Pcr) and ultrafiltration (UF4) for each patient was calculated using the least square regression line equation...
September 28, 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/28931894/factors-generating-glucose-degradation-products-in-sterile-glucose-solutions-for-infusion-statistical-relevance-determination-of-their-impacts
#3
J Haybrard, N Simon, C Danel, C Pinçon, C Barthélémy, F J Tessier, B Décaudin, E Boulanger, P Odou
Sterilising glucose solutions by heat promotes the generation of a large number of glucose degradation products (GDPs). It has been shown that high levels of GDPs may result in Advanced Glycation End products that have an impact on cellular homeostasis and health in general. If data is available for peritoneal dialysis solutions, little has been published for glucose infusion fluids. It is essential to identify the parameters causing the formation of GDPs and so limit the risk of exposing patients to them. After quantifying both 5-hydroxymethyl-2-furfural, considered as an important indicator of degradation, and 2-furaldehyde, an ultimate GDP of one degradation pathway, in marketed solutions, the aim of this work is to build a model integrating all the parameters involved in the formation rates of these two GDPs: supplier, glucose amount, container material, oxygen permeability coefficient and time-lapse since manufacture...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28912982/severe-thyrotoxicosis-secondary-to-povidone-iodine-from-peritoneal-dialysis
#4
Kirstie Lithgow, Christopher Symonds
A 73-year-old male on home peritoneal dialysis (PD) with recent diagnosis of atrial fibrillation presented with fatigue and dyspnea. Hyperthyroidism was diagnosed with TSH < 0.01 mIU/L and FT4 > 100 pmol/L. He had no personal or family history of thyroid disease. There had been no exposures to CT contrast, amiodarone, or iodine. Technetium thyroid scan showed diffusely decreased uptake. He was discharged with a presumptive diagnosis of thyroiditis. Three weeks later, he had deteriorated clinically...
2017: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/28859606/no-increase-in-small-solute-transport-in-peritoneal-dialysis-patients-treated-without-hypertonic-glucose-for-fifty-four-months
#5
Dominique Pagniez, Alain Duhamel, Eric Boulanger, Celia Lessore de Sainte Foy, Jean-Baptiste Beuscart
BACKGROUND: Glucose is widely used as an osmotic agent in peritoneal dialysis (PD), but exerts untoward effects on the peritoneum. The potential protective effect of a reduced exposure to hypertonic glucose has never been investigated. METHODS: The cohort of PD patients attending our center which tackled the challenge of a restricted use of hypertonic glucose solutions has been prospectively followed since 1992. Small-solute transport was assessed using an equivalent of the glucose peritoneal equilibration test after 6 months, and then every year...
August 31, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28858719/liposome-supported-enzymatic-peritoneal-dialysis
#6
Anna Pratsinis, Stefanie Zuercher, Vincent Forster, Eric J Fischer, Paola Luciani, Jean-Christophe Leroux
Compared to hemodialysis, peritoneal dialysis represents a more straightforward and less invasive alternative, though current solutions are not as effective. Herein, the feasibility of liposome-supported enzymatic peritoneal dialysis (LSEPD) is explored to increase the functionality of peritoneal dialysis for the model indication acute alcohol poisoning. Enzyme-loaded liposomes (E-Liposomes) containing alcohol metabolizing enzymes, alcohol oxidase and catalase, are developed and their in vitro and in vivo performances investigated...
August 14, 2017: Biomaterials
https://www.readbyqxmd.com/read/28843932/hypervolemia-hypoalbuminemia-and-mitral-calcification-as-markers-of-cardiovascular-risk-in-peritoneal-dialysis-patients
#7
Sara Querido, Patrícia Quadros Branco, Henrique Silva Sousa, Teresa Adragão, Pedro Araújo Gonçalves, Maria Augusta Gaspar, José Diogo Barata
INTRODUCTION: Mortality in patients with end-stage renal disease is higher than in the general population. This is linked to traditional and non-traditional cardiovascular (CV) risk factors, as well as with risk factors associated with end-stage renal disease itself. The aim of this study is to identify CV risk markers in patients beginning peritoneal dialysis (PD) and their association with CV events and CV mortality. METHODS: This was a retrospective cohort study of 112 incident PD patients, in which demographic, clinical and laboratory parameters, valvular calcifications, types of PD solutions, hospitalizations, CV events and death were analyzed...
August 23, 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/28766494/resting-energy-expenditure-a-valuable-predictor-for-kt-vurea-in-peritoneal-dialysis-patients%C3%A2
#8
Tian Xu, Jingyuan Xie, Weiming Wang, Hong Ren, Nan Chen
OBJECTIVE: The objective of this study was to identify an effective method for predicting small-molecule solute removal at the commencement of or before peritoneal dialysis (PD). METHODS: The PD patients with a dialysis delivery of 8 L/d and a residual kidney function (RKF) ≤ 5 mL/min were enrolled in the study. Fat-free lean body mass (FFM) and resting energy expenditure (REE) were measured using bioelectrical impedance (BIA). A receiver operating characteristic (ROC) curve was drawn to determine the threshold value for REE...
September 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28765896/1-25-oh-2d3-treatment-attenuates-high-glucose%C3%A2-induced-peritoneal-epithelial-to-mesenchymal-transition-in-mice
#9
Lina Yang, Yi Fan, Xiuli Zhang, Wenyu Huang, Jianfei Ma
It has been previously demonstrated that 1,25(OH)2D3 prevents the progression of epithelial to mesenchymal transition (EMT). However, it remains unclear whether 1,25(OH)2D3 has a role in peritoneal EMT stimulated by high glucose (HG) peritoneal dialysis fluid (PDF). The present study was performed to investigate the role of 1,25(OH)2D3 in the progression of EMT in the peritoneal mesothelium. A total of 35 male Kunming mice were randomly assigned into seven groups. In the control group, no diasylate or saline was infused...
October 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28761770/extended-peritoneal-dialysis-and-renal-recovery-in-hiv-infected-patients-with-prolonged-aki-a-report-of-2-cases
#10
Donlawat Saengpanit, Pongpratch Puapatanakul, Piyaporn Towannang, Talerngsak Kanjanabuch
Peritoneal dialysis (PD) has recently been established as a treatment option for renal replacement therapy (RRT) in patients with acute kidney injury (AKI). Its efficacy in providing fluid and small solute removal has also been demonstrated in clinical trials and is equivalent to hemodialysis (HD). However, effect of RRT modality on renal recovery after AKI remains a controversy. Moreover, the setting of human immunodeficiency virus- (HIV-) infected patients with AKI requiring RRT makes the decision on RRT initiation and modality selection more complicated...
2017: Case Reports in Nephrology
https://www.readbyqxmd.com/read/28739249/intraperitoneal-pressure-in-peritoneal-dialysis
#11
Vicente Pérez Díaz, Sandra Sanz Ballesteros, Esther Hernández García, Elena Descalzo Casado, Irene Herguedas Callejo, Cristina Ferrer Perales
The measure of intraperitoneal pressure in peritoneal dialysis is easy and provides clear therapeutic benefits. However it is measured only rarely in adult peritoneal dialysis units. This review aims to disseminate the usefulness of measuring intraperitoneal pressure. This measurement is performed in supine before initiating the drain of a manual exchange with "Y" system, by raising the drain bag and measuring from the mid-axillary line the height of the liquid column that rises from the patient. With typical values of 10-16 cmH2O, intraperitoneal pressure should never exceed 18 cmH2O...
July 21, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28729965/fluid-overload-as-a-major-target-in-management-of-cardiorenal-syndrome-implications-for-the-practice-of-peritoneal-dialysis
#12
REVIEW
Amir Kazory
Congestion is an integral component of cardiorenal syndrome and portends an adverse impact on the outcomes. Recent studies suggest that congestion has the ability of modulating the interactions between the kidney and the heart in this setting. Peritoneal dialysis (PD) is a home-based therapeutic modality that is not only offered to patients with end-stage renal disease to provide solute clearance and ultrafiltration, but it has also been used in patients with refractory heart failure and fluid overload to help optimize volume status...
July 6, 2017: World Journal of Nephrology
https://www.readbyqxmd.com/read/28708209/changes-of-peritoneal-transport-parameters-with-time-on-dialysis-assessment-with-sequential-peritoneal-equilibration-test
#13
Jacek Waniewski, Stefan Antosiewicz, Daniel Baczynski, Jan Poleszczuk, Mauro Pietribiasi, Bengt Lindholm, Zofia Wankowicz
BACKGROUND: Sequential peritoneal equilibration test (sPET) is based on the consecutive performance of the peritoneal equilibration test (PET, 4-hour, glucose 2.27%) and the mini-PET (1-hour, glucose 3.86%), and the estimation of peritoneal transport parameters with the 2-pore model. It enables the assessment of the functional transport barrier for fluid and small solutes. The objective of this study was to check whether the estimated model parameters can serve as better and earlier indicators of the changes in the peritoneal transport characteristics than directly measured transport indices that depend on several transport processes...
July 11, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28698252/peritoneal-equilibration-test-reference-values-using-a-3-86-glucose-solution-during-the-first-year-of-peritoneal-dialysis-results-of-a-multicenter-study-of-a-large-patient-population
#14
Vincenzo La Milia, Gianfranca Cabiddu, Giovanbattista Virga, Valerio Vizzardi, Anna Giuliani, Viviana Finato, Mariano Feriani, Armando Filippini, Loris Neri, Lucia Lisi
BACKGROUND: The original peritoneal equilibration test (PET) was used to classify peritoneal dialysis (PD) patients using a 2.27% glucose solution. It has since been suggested that a 3.86% glucose solution be used because this provides better information about ultrafiltration (UF) capacity and the sodium (Na) sieving of the peritoneal membrane. OBJECTIVE: The aim of this study was to determine reference values for a PET using a 3.86% glucose solution (PET-3.86%)...
July 11, 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/28685187/compatibility-of-fosfomycin-with-different-commercial-peritoneal-dialysis-solutions
#15
M Kussmann, A Baumann, S Hauer, P Pichler, M Zeitlinger, M Wiesholzer, H Burgmann, W Poeppl, G Reznicek
For treatment of peritoneal dialysis-related peritonitis, intraperitoneal administration of antibiotics remains the preferable route. For home-based therapy, patients are commonly supplied with peritoneal dialysis fluids already containing antimicrobial agents. The present study set out to investigate the compatibility of fosfomycin with different peritoneal dialysis fluids, namely, Extraneal(®), Nutrineal(®), Physioneal(®) 1.36% and Physioneal(®) 2.27%, under varying storage conditions. The peritoneal dialysis fluid bags including 4 g fosfomycin were stored over 14 days at refrigeration temperature (6°C) and room temperature (25°C) and over 24 h at body temperature (37°C)...
July 6, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28676511/absence-of-post-transplantation-encapsulating-peritoneal-sclerosis-after-relatively-short-exposure-to-peritoneal-dialysis-prospective-analysis-using-repeated-abdominal-ct-scanning
#16
Alferso C Abrahams, Maaike K van Gelder, Jan Willem van der Veer, Pim A de Jong, Maarten S van Leeuwen, Walther H Boer
BACKGROUND: Encapsulating peritoneal sclerosis (EPS) is the most severe complication of peritoneal dialysis (PD). Several retrospective reports published between 2007 and 2009 have suggested an increasing incidence of EPS occurring after kidney transplantation. We conducted a prospective observational study to determine the incidence of post-transplantation EPS and identify possible risk factors. METHODS: Consecutive PD patients undergoing kidney transplantation between 2009 and 2013 were included...
July 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/28676508/the-potential-cardiovascular-benefits-of-low-glucose-degradation-product-biocompatible-peritoneal-dialysis-fluids-a-review-of-the-literature
#17
REVIEW
Charlotte E Grantham, Katherine L Hull, Matthew P M Graham-Brown, Daniel S March, James O Burton
Cardiovascular mortality in the end-stage renal disease (ESRD) population remains the leading cause of death. Targeting traditional cardiovascular risk factors has proven unsuccessful in this patient population, and therefore attention has turned to risk factors related to chronic kidney disease (CKD). The toxicity of high-glucose peritoneal dialysis (PD) solutions has been well documented. The breakdown of glucose into glucose degradation products (GDP) and advanced glycation end-products (AGE) has the ability to alter cell viability and cause premature apoptosis and is strongly correlated with interstitial fibrosis and microvascular sclerosis...
July 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/28674854/icodextrin-and-peritoneal-dialysis-advantages-and-new-applications
#18
REVIEW
Periklis Dousdampanis, Carlos Guido Musso, Konstantina Trigka
The impact of icodextrin (ico) on peritoneal dialysis (PD) extension and patient survival is well established. Predominantly, ico-based solutions were prescribed in high-transporter PD patients. Advantages of the ico-based solutions include increased biocompatibility, avoidance of glucotoxicity, enhanced ultrafiltration failure (UF), sodium removal rates, better metabolic and blood pressure control. Bimodal solutions and twice daily exchanges of ico-based solutions are two newly introduced strategies to avoid glucose exposure and/or enhance UF in PD patients with UF failure...
July 3, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28659813/human-peritoneal-mesothelial-cell-death-induced-by-high-glucose-hypertonic-solution-involves-ca-2-and-na-ions-and-oxidative-stress-with-the-participation-of-pkc-nox2-and-pi3k-akt-pathways
#19
Felipe Simon, Pablo Tapia, Ricardo Armisen, Cesar Echeverria, Sebastian Gatica, Alejandro Vallejos, Alejandro Pacheco, Maria E Sanhueza, Miriam Alvo, Erico Segovia, Rubén Torres
Chronic peritoneal dialysis (PD) therapy is equally efficient as hemodialysis while providing greater patient comfort and mobility. Therefore, PD is the treatment of choice for several types of renal patients. During PD, a high-glucose hyperosmotic (HGH) solution is administered into the peritoneal cavity to generate an osmotic gradient that promotes water and solutes transport from peritoneal blood to the dialysis solution. Unfortunately, PD has been associated with a loss of peritoneal viability and function through the generation of a severe inflammatory state that induces human peritoneal mesothelial cell (HPMC) death...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28624215/periostin-binding-dna-aptamer-treatment-ameliorates-peritoneal-dialysis-induced-peritoneal-fibrosis
#20
Bo Young Nam, Jung Tak Park, Young Eun Kwon, Jung Pyo Lee, Jong Ha Jung, Youndong Kim, Seonghun Kim, Jimin Park, Jae Eun Um, Meiyan Wu, Seung Hyeok Han, Tae-Hyun Yoo, Shin-Wook Kang
Peritoneal fibrosis is a major complication in peritoneal dialysis (PD) patients, which leads to dialysis discontinuation. Periostin, increased by transforming growth factor β1 (TGF-β1) stimulation, induces the expression of extracellular matrix (ECM) genes. Aberrant periostin expression has been demonstrated to be associated with PD-related peritoneal fibrosis. Therefore, the effect of periostin inhibition by an aptamer-based inhibitor on peritoneal fibrosis was evaluated. In vitro, TGF-β1 treatment upregulated periostin, fibronectin, α-smooth muscle actin (α-SMA), and Snail expression and reduced E-cadherin expression in human peritoneal mesothelial cells (HPMCs)...
June 16, 2017: Molecular Therapy. Nucleic Acids
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