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https://www.readbyqxmd.com/read/28546366/characteristics-and-clinical-outcomes-of-end-stage-renal-disease-patients-on-peritoneal-dialysis-for-over-15-years-a-single-center-experience
#1
Youn Kyung Kee, Jung Tak Park, Chang-Yun Yoon, Hyoungnae Kim, Seohyun Park, Hae Ryong Yun, Su-Young Jung, Jong Hyun Jhee, Hyung Jung Oh, Seung Hyeok Han, Tae-Hyun Yoo, Shin-Wook Kang
♦Background: Maintaining peritoneal dialysis (PD) for a long time is problematic owing to a number of factors. This study aimed to clarify the characteristics and examine the clinical outcomes of patients who received PD as a long-term dialysis modality. ♦ Methods: All end-stage renal disease (ESRD) patients who initiated PD at Yonsei University Health System between 1987 and 2000 were screened. Patients who maintained PD for over 15 years were classified as the long-term PD group and those who were treated with PD for less than 5 years were included in the short-term PD group...
May 25, 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/28540200/targeting-cannabinoid-signaling-for-peritoneal-dialysis-induced-oxidative-stress-and-fibrosis
#2
REVIEW
Chih-Yu Yang, Yat-Pang Chau, Ann Chen, Oscar Kuang-Sheng Lee, Der-Cherng Tarng, An-Hang Yang
Long-term exposure to bioincompatible peritoneal dialysis (PD) solutions frequently results in peritoneal fibrosis and ultrafiltration failure, which limits the life-long use of and leads to the cessation of PD therapy. Therefore, it is important to elucidate the pathogenesis of peritoneal fibrosis in order to design therapeutic strategies to prevent its occurrence. Peritoneal fibrosis is associated with a chronic inflammatory status as well as an elevated oxidative stress (OS) status. Beyond uremia per se, OS also results from chronic exposure to high glucose load, glucose degradation products, advanced glycation end products, and hypertonic stress...
May 6, 2017: World Journal of Nephrology
https://www.readbyqxmd.com/read/28540060/microparticle-formation-in-peritoneal-dialysis-a-proof-of-concept-study
#3
Shareef Akbari, Rima Abou-Arkoub, Suzy Sun, Swapnil Hiremath, Arkadiy Reunov, Brendan B McCormick, Marcel Ruzicka, Dylan Burger
BACKGROUND: Injury to the mesothelial layer of the peritoneal membrane during peritoneal dialysis (PD) is implicated in loss of ultrafiltration capacity, but there are no validated biomarkers for mesothelial cell injury. Microparticles (MPs) are 0.1 to 1.0 µm membrane vesicles shed from the cell surface following injury and are sensitive markers of tissue damage. Formation of MPs in the peritoneal cavity during PD has not been reported to date. METHODS: We designed a single-center, proof of concept study to assess whether peritoneal solution exposure induces formation of mesothelial MPs suggestive of PD membrane injury...
2017: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/28538146/ligand-mediated-folding-of-the-ompa-periplasmic-domain-from-acinetobacter-baumannii
#4
Ameeq Ul Mushtaq, Jeong Soon Park, Sung-Hun Bae, Hye-Yeon Kim, Kwon Joo Yeo, Eunha Hwang, Ki Yong Lee, Jun-Goo Jee, Hae-Kap Cheong, Young Ho Jeon
The periplasmic domain of OmpA from Acinetobacter baumannii (AbOmpA-PD) binds to diaminopimelate and anchors the outer membrane to the peptidoglycan layer in the cell wall. Although the crystal structure of AbOmpA-PD with its ligands has been reported, the mechanism of ligand-mediated folding of AbOmpA remains elusive. Here, we report that in vitro refolded apo-AbOmpA-PD in the absence of ligand exists as a mixture of two partially folded forms in solution: mostly unfolded (apo-state I) and hololike (apo-state II) states...
May 23, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28535838/are-sainfoin-or-protein-supplements-alternatives-to-control-small-strongyle-infection-in-horses
#5
C Collas, G Sallé, B Dumont, J Cabaret, J Cortet, W Martin-Rosset, L Wimel, G Fleurance
The spread of anthelmintic resistance in equine strongyle nematodes has become a major problem, advocating for the development of alternative control for strongyles. Our study consisted of both in vivo and in vitro experiments. We investigate for the first time the efficacy of a short-term consumption of tannin-rich sainfoin (Onobrychis viciifolia) or extra proteins in naturally infected horses. We used 30 horses allocated into three groups of 10 individuals that received for 18 days either (i) a tannin-rich diet with 70% DM sainfoin pellets (Sd), (ii) a protein-rich diet with 52% DM Italian rye-grass pellets and 18% DM grinded linseed expeller (Pd), or (iii) a control diet with 45% DM barley and 25% DM cereal-based pellets (Cd)...
May 24, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28534573/solvent-dependent-nuclearity-geometry-and-catalytic-activity-of-sphos-pd-ph-cl-2
#6
John B Brazier, Mark A Newton, Elena M Barreiro, Luis A Adrio, Leticia Naya, King Kuok Mimi Hii
The nuclearity and structures of the palladium complex [(SPhos)Pd(Ph)Cl]2 in the solid and solution states are revisited using a combination of Extended X-ray Absorption Fine Structure (EXAFS) spectroscopy, NMR spectroscopy, mass spectrometry, DFT calculations and trapping experiments. The complex was tested for its catalytic activity in the coupling reaction between chlorobenzene and n-hexylamine, where different deactivation behaviours were observed in toluene, 1,4-dioxane and DMF.
May 23, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28534200/atrophy-of-calf-muscles-by-unloading-results-in-an-increase-of-tissue-sodium-concentration-and-fat-fraction-decrease-a-23-na-mri-physiology-study
#7
D A Gerlach, K Schopen, P Linz, B Johannes, J Titze, J Zange, J Rittweger
PURPOSE: (23)Na MRI demonstrated increased tissue sodium concentrations in a number of pathologies. Acute atrophy results in muscle fibre volume shrinking that may result in a relative increase of extracellular volume and might affect sodium concentration. Thus, we hypothesized that local unloading of the calf muscles would lead to a decrease in muscle volume and an increase in muscle tissue sodium concentration. METHOD: One lower leg of 12 healthy male subjects was submitted to a 60 day long period of unloading using the Hephaistos orthosis, while the other leg served as control...
May 22, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28530740/extraction-behaviour-and-mechanism-of-pt-iv-and-pd-ii-by-liquid-liquid-extraction-with-an-ionic-liquid-hbbim-br
#8
Wenhui Liu, Qi Wang, Yan Zheng, Shubin Wang, Yan Yan, Yanzhao Yang
In this study, a method of one-step separation and recycling of high purity Pd(ii) and Pt(iv) using an ionic liquid, 1-butyl-3-benzimidazolium bromate ([HBBIm]Br), was investigated. The effects of [HBBIm]Br concentration, initial metal concentration, and loading capacity of [HBBIm]Br were examined in detail. It was observed that [HBBIm]Br was a very effective extractant for selectively extracting Pd(ii) and precipitating Pt(iv). Through selectively extracting Pd(ii) and precipitating Pt(iv), each metal with high purity was separately obtained from mixed Pd(ii) and Pt(iv) multi-metal solution...
May 22, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28525669/relationship-between-bioimpedance-determined-body-composition-and-peritoneal-transport-in-peritoneal-dialysis
#9
Bernardo M da Costa, Gloria Del Peso, Maria Auxiliadora Bajo, Gilda Carreño, Marta Ferreira, Carina Ferreira, Rafael Selgas
PURPOSE: In peritoneal dialysis (PD) patients, body fluid homeostasis is dependent on peritoneal elimination of water and solutes. Patients with less favorable peritoneal transport parameters should be more overhydrated. Despite this, the association between faster transport and overhydration (OH) is weak, and the factors that influence hydration status are still poorly characterized. Modified peritoneal equilibration tests (PET) offer us new parameters that might correlate better with hydration status, like free water transport (FWT)...
May 18, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28522399/anti-allergic-and-profilaggrin-proflg-mrna-expression-modulatory-effects-of-sacran
#10
Nlandu R Ngatu, Keiichi Motoyama, Yasumitsu Nishimura, Maiko Kaneko Okajima, Ryoji Hirota, Taishi Higashi, Suni Lee, Hidetoshi Arima, Mitsunori Ikeda, Sayumi Nojima, Tatsuo Kaneko
Atopic dermatitis (AD) is a skin disorder characterized by filaggrin (FLG) defect. We evaluated sacran's effects on dust-mite extracts (DME)-induced AD-like disease and also its effect on profilaggrin (proFLG) in a murine model of 2,4-dinitroflurobenze (DNFB)-induced contact hypersensitivity. In the murine AD-like disease model, allergic NC/Nga mice (N=60) were randomly divided into five treatment groups of 12 animals each: 0.2% and 1%sacran; 0.1% Tacrolimus; Vaseline and buffer-treated controls. Blood samples were drawn and serum levels of representative Th-1, Th-2 and also Th-17 (IL-17A) cytokines were assayed by Cytometric Bead Array (CBA)...
May 15, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28497967/interactions-of-metal-based-and-ligand-based-electronic-spins-in-neutral-tripyrrindione-%C3%AF-dimers
#11
Ritika Gautam, Andrei V Astashkin, Tsuhen M Chang, Jason Shearer, Elisa Tomat
The ability of tetrapyrrolic macrocycles to stabilize unpaired electrons and engage in π-π interactions is essential for many electron-transfer processes in biology and materials engineering. Herein, we demonstrate that the formation of π dimers is recapitulated in complexes of a linear tripyrrolic analogue of naturally occurring pigments derived from heme decomposition. Hexaethyltripyrrindione (H3TD1) coordinates divalent transition metals (i.e., Pd, Cu, Ni) as a stable dianionic radical and was recently described as a robust redox-active ligand...
May 12, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28496463/antibacterial-loaded-spray-dried-chitosan-polyelectrolyte-complexes-as-dry-powder-aerosol-for-the-treatment-of-lung-infections
#12
Brahmeshwar Mishra, Madhusmita Mishra, Sarita Kumari Yadav
Inhalation delivery of aerosolized antibacterials is preferred over conventional methods of delivery for targeting lung infection. The present study is concerned with the development and characterization of a novel, spray dried, aerosolized, chitosan polyelectrolyte complex (PEC) based microparticles containing antibacterials for the treatment of lung infections. Chitosan polyelectrolyte complex microparticles were formulated by spray drying process. Prepared spray dried chitosan PEC microparticles were studied for surface morphology, drug encapsulation efficiency, moisture content, Carr's index, solid state interaction by XRD, aerosolization behaviour and in-vitro drug release...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/28492518/environmental-barriers-to-participation-of-preschool-children-with-and-without-physical-disabilities
#13
Lin-Ju Kang, Ming-Chieh Hsieh, Hua-Fang Liao, Ai-Wen Hwang
Environment plays a vital role in affecting participation of young children in home, school, and community. Knowledge of environmental barriers helps to develop solutions or strategies that enable participation. The study compared the environmental barriers perceived by parents of preschool children with physical disabilities (PD, n = 142) and with typical development (TD, n = 192) in Taiwan. Parents identified environmental barriers by structured interview using the Chinese version of the Child and Adolescent Scale of Environment (CASE-C)...
May 11, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28486991/exploring-the-utility-and-scalability-of-a-telehomecare-intervention-for-patients-with-chronic-kidney-disease-undergoing-peritoneal-dialysis-a-study-protocol
#14
Lianne Jeffs, Arsh Kumar Jain, Rachel HiuTung Man, Nike Onabajo, Laura Desveaux, James Shaw, Jennifer Hensel, Payal Agarwal, Marianne Saragosa, Trevor Jamieson, Ivy Wong, Maria Maione, R Sacha Bhatia
BACKGROUND: Chronic Kidney Disease (CKD) is a pressing global health concern that is placing increased strain on health care resources. CKD patients regularly receive peritoneal dialysis as a common CKD treatment. An emerging technological solution is telehomecare as way to support patients receiving PD in their homes. This study protocol outlines a mixed methods evaluation exploring a telehomecare developed to enhance CKD patients' outcomes and experiences. The study aims to assess the usability, acceptability and scalability of this virtual care application...
May 10, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28486098/preparation-of-212-pb-labeled-monoclonal-antibody-using-a-novel-224-ra-based-generator-solution
#15
Sara Westrøm, Roman Generalov, Tina B Bønsdorff, Roy H Larsen
INTRODUCTION: Alpha-emitting radionuclides have gained considerable attention as payloads for cancer targeting molecules due to their high cytotoxicity. One attractive radionuclide for this purpose is (212)Pb, which by itself is a β-emitter, but acts as an in vivo generator for its short-lived α-emitting daughters. The standard method of preparing (212)Pb-labeled antibodies requires handling and evaporation of strong acids containing high radioactivity levels by the end user. An operationally easier and more rapid process could be useful since the 10...
April 26, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28482488/direct-bioactive-ceramics-coating-via-reactive-growing-integration-layer-method-on-%C3%AE-ti-alloy
#16
Chi-Huang Huang, Rong-Sheng Chen, Masahiro Yoshimura
This paper demonstrates Ca-P-rich bio-ceramic and hydroxyapatite (HA) coatings formed directly from the solution of calcium acetate (CA) and sodium dihydrogen phosphate (SDP) on α-Ti-alloy substrates by Growing Integration Layer (GIL) technology under DC power supply. The composition of the α-Ti-alloy was Ti7Cu5Sn. The GIL coated films formed in 30min time with different voltages applied had porous and rough ceramic surfaces. They consisted mostly of various oxides like rutile, anatase, and calcium phosphates (including hydroxyapatite) that reduce corrosion rate and increase biocompatibility...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28467708/novel-benzothiazole-derivatives-as-fluorescent-probes-for-detection-of-%C3%AE-amyloid-and-%C3%AE-synuclein-aggregates
#17
Hiroyuki Watanabe, Masahiro Ono, Taisuke Ariyoshi, Rikako Katayanagi, Hideo Saji
Deposits of β-amyloid (Aβ) and α-synuclein (α-syn) are the hallmark of Alzheimer's disease (AD) and Parkinson's disease (PD), respectively. The detection of these protein aggregates with fluorescent probes is particularly of interest for preclinical studies using fluorescence microscopy on human brain tissue. In this study, we newly designed and synthesized three push-pull benzothiazole (PP-BTA) derivatives as fluorescent probes for detection of Aβ and α-syn aggregates. Fluorescence intensity of all PP-BTA derivatives significantly increased upon binding to Aβ(1-42) and α-syn aggregates in solution...
May 3, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28467040/one-pot-synthesis-of-noble-metal-zinc-oxide-composites-with-controllable-morphology-and-high-catalytic-performance
#18
Zhihong Bao, Yue Yuan, Chunbo Leng, Li Li, Kun Zhao, Zhenhua Sun
The combination of noble metal and oxide support is a good approach to reduce the cost of noble metal catalyst and improve the stability of nanocatalyst in chemical reactions. Here, noble metal/zinc oxide composites, including Pd/ZnO and Pt/ZnO, have been facilely prepared through the general one-pot hydrothermal method. Importantly, the morphology of composites can be tuned from tube, flower, and star to skin needling-like shapes by easily adjusting the alkalinity of the reaction solution. By investigating the growth mechanism and influencing factors of the morphology of noble metal/zinc oxide composites, the differences of the morphology of composites can be ascribed to various growing units and directions of ZnO crystal under different alkalinities...
May 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28437068/observing-the-overgrowth-of-a-second-metal-on-silver-cubic-seeds-in-solution-by-surface-enhanced-raman-scattering
#19
Yun Zhang, Jingyue Liu, Jaewan Ahn, Ting-Hui Xiao, Zhi-Yuan Li, Dong Qin
We report the development of an isocyanide-based molecular probe for in situ characterizing the overgrowth of a second metal on silver nanocrystal seeds in solution by surface-enhanced Raman scattering (SERS). As the first demonstration, we elucidate that the vibrational frequency of 2,6-dimethylphenyl isocyanide (2,6-DMPI) can serve as a distinctive reporter for capturing the nucleation of Pt on the edges of Ag nanocubes in the aqueous solution containing a Pt precursor, ascorbic acid, and poly(vinylpyrrolidone) under ambient conditions...
April 26, 2017: ACS Nano
https://www.readbyqxmd.com/read/28432894/the-structure-correlates-and-treatment-related-changes-of-mindfulness-facets-across-the-anxiety-disorders-and-obsessive-compulsive-disorder
#20
Lance L Hawley, Jenny Rogojanski, Valerie Vorstenbosch, Lena C Quilty, Judith M Laposa, Neil A Rector
Research with non-clinical and clinical samples has examined how mindfulness concepts relate to psychological symptom presentations. However, there is less clarity when examining treatment-seeking patients who experience DSM-diagnosed anxiety and obsessional disorders - both cross-sectionally, and following empirically-supported treatments. The Five Facet Mindfulness Questionnaire (FFMQ; Baer, Smith, Hopkins, Krietemeyer, & Toney, 2006) conceptualizes mindfulness as consisting of five facets: Observing, Describing, Acting with Awareness, Nonreactivity, and Nonjudging...
March 14, 2017: Journal of Anxiety Disorders
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