Till Grandjean, Natarajan Perumal, Caroline Manicam, Björn Matthey, Tao Wu, Daniel G E Thiem, Stefan Stein, Dirk Henrich, Peer W Kämmerer, Bilal Al-Nawas, Ulrike Ritz, Sebastian Blatt
INTRODUCTION: Autologous platelet concentrate (APC) are pro-angiogenic and can promote wound healing and tissue repair, also in combination with other biomaterials. However, challenging defect situations remain demanding. 3D bioprinting of an APC based bioink encapsulated in a hydrogel could overcome this limitation with enhanced physio-mechanical interface, growth factor retention/secretion and defect-personalized shape to ultimately enhance regeneration. METHODS: This study used extrusion-based bioprinting to create a novel bioink of alginate/cellulose hydrogel loaded with thrombocyte concentrate...
2024: Frontiers in Bioengineering and Biotechnology