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https://www.readbyqxmd.com/read/27914126/effects-of-platelet-rich-plasma-on-kidney-regeneration-in-gentamicin-induced-nephrotoxicity
#1
Abbas Moghadam, Tahereh Talaei Khozani, Afsaneh Mafi, Mohammad Reza Namavar, Farzaneh Dehghani
Platelet-rich plasma (PRP) as a source of growth factors may induce tissue repairing and improve fibrosis. This study aimed to assess the effects of PRP on kidney regeneration and fibrosis in gentamicin (GM)-induced nephrotoxicity rat model by stereological study. Thirty-two male rats were selected. Nephrotoxicity was induced in animals by administration of GM (80 mg/kg/daily, intraperitoneally [IP], 8 day) and animals were treated by PRP (100 μL, intra-cortical injection using surgical microscopy, single dose)...
January 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27912815/regenerative-endodontics-by-cell-homing
#2
REVIEW
Ling He, Juan Zhong, Qimei Gong, Bin Cheng, Sahng G Kim, Junqi Ling, Jeremy J Mao
Apical revascularization (AR) and platelet-rich plasma have been used to restore dental pulp vitality in infected immature permanent teeth. Two regenerative therapies are cell transplantation and cell homing. This article updates and benchmarks these therapies with cell homing. A case report concluded that AR increased root length; however, quantitative and statistical assessments disproved this. Regenerative endodontic therapies require prospective clinical trials demonstrating safety and efficacy. These therapies are intrinsically susceptible to procedural and patient variations...
January 2017: Dental Clinics of North America
https://www.readbyqxmd.com/read/27909693/unfractionated-and-low-molecular-weight-heparin-and-the-phosphodiesterase-inhibitors-ibmx-and-cilostazol-block-ex-vivo-equid-herpesvirus-type-1-induced-platelet-activation
#3
Tracy Stokol, Priscila B D Serpa, Muhammad N Zahid, Marjory B Brooks
Equid herpes virus type-1 (EHV-1) is a major pathogen of horses, causing abortion storms and outbreaks of herpes virus myeloencephalopathy. These clinical syndromes are partly attributed to ischemic injury from thrombosis in placental and spinal vessels. The mechanism of thrombosis in affected horses is unknown. We have previously shown that EHV-1 activates platelets through virus-associated tissue factor-initiated thrombin generation. Activated platelets participate in thrombus formation by providing a surface to localize coagulation factor complexes that amplify and propagate thrombin generation...
2016: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/27908451/allogeneic-platelet-rich-plasma-at-the-dawn-of-an-off-the-shelf-therapy
#4
Eduardo Anitua, Roberto Prado, Gorka Orive
A new therapeutic tool is emerging based on a biomimetic strategy: platelet-rich plasma (PRP) technology. Allogeneic off-the-shelf PRP represents a safe and cost-effective treatment for osteoarthritis and related diseases. This breakthrough opens the door not only to improved treatments and opportunities but also to new challenges with multiple uncertainties.
November 28, 2016: Trends in Biotechnology
https://www.readbyqxmd.com/read/27906940/a-new-technique-for-the-treatment-of-lumbar-facet-joint-syndrome-using-intra-articular-injection-with-autologous-platelet-rich-plasma
#5
Jiuping Wu, Zhenwu Du, Yang Lv, Jun Zhang, Wei Xiong, Ruiqiang Wang, Rui Liu, Guizhen Zhang, Qinyi Liu
BACKGROUND AND OBJECTIVES: Lumbar facet joint syndrome is currently suggested to be a main source of axial low back pain, and a large portion of axial low back pain is caused by disorders in lumbar facet joints. Intra-articular injection is one of the most common treatment methods in the early clinical application. Therefore, we attempt to seek a new injectable material, autologous platelet rich plasma (PRP), to treat lumbar facet syndrome, as well as to assess its therapeutic effectiveness and safety...
November 2016: Pain Physician
https://www.readbyqxmd.com/read/27904584/effectiveness-and-relevant-factors-of-platelet-rich-plasma-treatment-in-managing-plantar-fasciitis-a-systematic-review
#6
REVIEW
Seet Khing Chiew, Thamil Selvee Ramasamy, Farahnaz Amini
BACKGROUND: Plantar fasciitis (PF) is a common foot complaint, affects both active sportsmen and physically inactive middle age group. It is believed that PF results from degenerative changes rather than inflammation. Platelet-rich plasma (PRP) therapy has been introduced as an alternative therapy for PF. This study is aimed to systematically review to the effectiveness and relevant factors of PRP treatment in managing PF. MATERIALS AND METHODS: A search was conducted in electronic databases, including PubMed, Scopus, and Google Scholar using different keywords...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27904531/effects-of-hyperbaric-oxygen-therapy-combined-with-platelet-rich-plasma-on-diabetic-wounds-an-experimental-rat-model
#7
Gündüz Yümün, Cüneyt Kahaman, Nail Kahaman, Ulviye Yalçınkaya, Aydin Akçılar, Engin Akgül, Ahmet Hakan Vural
INTRODUCTION: Hyperbaric oxygen and platelet-rich plasma are used in the treatment of diabetic wounds. The aim of this study is to evaluate the effects of hyperbaric oxygen therapy and autologous platelet concentrates in healing diabetic wounds. MATERIAL AND METHODS: Thirty-six female Wistar albino rats were used in this study. Diabetes mellitus was induced chemically with an intraperitoneal injection of streptozotocin. The rats were divided into a control group, a hyperbaric oxygen group, a platelet-rich plasma group, and a combined therapy group...
December 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27904271/histologic-evidence-of-new-collagen-formulation-using-platelet-rich-plasma-in-skin-rejuvenation-a-prospective-controlled-clinical-study
#8
Ozlem Karabudak Abuaf, Hamza Yildiz, Hüseyin Baloglu, Memet Ersan Bilgili, Hasan Aktug Simsek, Bilal Dogan
BACKGROUND: Platelet-rich plasma (PRP) is an autologous concentration of human platelets contained in a small volume of plasma and has recently been shown to accelerate rejuvenate aging skin by various growth factors and cell adhesion molecules. OBJECTIVE: This study was conducted to evaluate the efficacy and safety of intradermal injection of PRP in the human facial rejuvenation. METHODS: This study was a prospective, single-center, single-dose, open-label, non-randomized controlled clinical study...
December 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27903591/platelet-rich-plasma-powder-a-new-preparation-method-for-the-standardization-of-growth-factor-concentrations
#9
Matthias Kieb, Frank Sander, Cornelia Prinz, Stefanie Adam, Anett Mau-Möller, Rainer Bader, Kirsten Peters, Thomas Tischer
BACKGROUND: Platelet-rich plasma (PRP) is widely used in sports medicine. Available PRP preparations differ in white blood cell, platelet, and growth factor concentrations, making standardized research and clinical application challenging. PURPOSE: To characterize a newly standardized procedure for pooled PRP that provides defined growth factor concentrations. STUDY DESIGN: Controlled laboratory study. METHODS: A standardized growth factor preparation (lyophilized PRP powder) was prepared using 12 pooled platelet concentrates (PCs) derived from different donors via apheresis...
November 30, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27901390/effects-of-various-antiplatelet-drugs-on-ex-vivo-platelet-activation-induced-by-equine-herpesvirus-type-1
#10
Daniela Hernandez, Wee Ming Yeo, Marjory B Brooks, Sally L Ness, Thomas J Divers, Tracy Stokol
OBJECTIVE To evaluate the effects of treatment of horses with standard platelet inhibitors on ex vivo inhibition of platelet activation by equine herpesvirus type I (EHV-I). ANIMALS II healthy adult horses. PROCEDURES In a double-blinded, placebo-controlled crossover study, horses were treated orally for 5 days with theophylline (5 mg/kg, q 12 h), pentoxifylline (10 mg/kg, q 12 h), clopidogrel bisulfate (4 mg/kg, q 24 h), acetylsalicylic acid (20 mg/kg, q 24 h), or placebo. Horses received all treatments, each separated by a 3-week washout period...
December 2016: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/27900700/platelet-rich-plasma-supplementation-in-arthroscopic-repair-of-full-thickness-rotator-cuff-tears-a-randomized-clinical-trial
#11
R D'Ambrosi, F Palumbo, A Paronzini, V Ragone, R M Facchini
BACKGROUND: Results on the effectiveness of PRP supplementation in arthroscopic rotator cuff repair are conflicting, making it difficult to draw definitive conclusions. METHODS: This was a prospective, randomized, and double-blind study with two groups of 20 patients each (PRP group and control group). Degenerative supraspinatus full-thickness tears grade C2-C3 were subjected to arthroscopic repair; PRP supplementation was given to patients in the PRP group. The outcomes were assessed by DASH, Constant scales, and ultrasound before and 6 months after surgery...
December 2016: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/27900305/microfracture-versus-microfracture-and-platelet-rich-plasma-arthroscopic-treatment-of-knee-chondral-lesions-a-two-year-follow-up-study
#12
Annalisa Mancò, Remo Goderecci, Anna Rughetti, Silvana DE Giorgi, Stefano Necozione, Alfredo Bernardi, Vittorio Calvisi
PURPOSE: the aim of this study was to describe and compare the clinical results obtained in patients affected by chondral lesions of the knee submitted to an arthroscopic treatment with the microfracture technique or microfracture + intraoperative autologous platelet-rich plasma (PRP) injection. METHODS: a prospective observational study was performed in patients affected by chondral lesions of the knee (classed as grade III-IV according to Outer-bridge's classification) and early osteoarthritis (classed as grade 1-2 according to the Kellgren-Lawrence classification)...
July 2016: Joints
https://www.readbyqxmd.com/read/27900294/efficacy-of-autologous-leukocyte-reduced-platelet-rich-plasma-therapy-for-patellar-tendinopathy-in-a-rat-treadmill-model
#13
Mamoru Yoshida, Hiroki Funasaki, Keishi Marumo
BACKGROUND: An autologous platelet-rich plasma (PRP) therapy has currently been applied for the tendinopathy; however, its efficacy and an optimal platelets concentration in PRP were uncertain. We analyzed them in an animal model prepared using a repetitive running exercise. METHODS: We made the tendinopathy rat model of patellar tendon using a rodent treadmill machine. Rats with tendinopathy were injected with leukocyte-reduced PRP at the platelets concentration of 1...
April 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/27900293/combined-use-of-platelet-rich-plasma-micro-fat-in-sport-and-race-horses-with-degenerative-joint-disease-preliminary-clinical-study-in-eight-horses
#14
Fabrizio Bembo, Julia Eraud, Cecile Philandrianos, Baptiste Bertrand, Alain Silvestre, Julie Veran, Florence Sabatier, Guy Magalon, Jeremy Magalon
BACKGROUND: To assess the safety and potential efficacy of a standardized technique consisting of intra-articular injection of 10 cc of a homogeneous mixed product using autologous micro-fat and platelet rich plasma (PRP) (ratio 1:1) in the carpus or the fetlock joint of sport horses presenting degenerative joint disease (DJD). METHODS: Eight sport horses with DJD confirmed by radiography and ultrasonography and causing lameness and the impossibility to compete were treated...
April 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/27900247/use-of-autologous-platelet-rich-fibrin-in-osseous-regeneration-after-cystic-enucleation-a-clinical-study
#15
Manzoor Dar, Tajamul Hakim, Ajaz Shah, Latief Najar, Gowhar Yaqoob, Faiqah Lanker
AIMS AND OBJECTIVES: The aim of this study was to evaluate the efficacy of PRF in osseous regeneration after enucleation of cystic lesions. The objectives of this study were as follows: (1) to evaluate osseous regeneration radiographically with the use of PRF in intrabony defects after cystic enucleation. (2) To evaluate the degree of bone density in intrabony defects with the use of PRF postoperatively after 1st, 3rd, and 6th months. SUBJECTS AND METHODS: 20 cases of cystic lesions were treated using PRF after cystic enucleation...
November 2016: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/27900155/normal-platelet-function-in-platelet-concentrates-requires-non-platelet-cells-a-comparative-in-vitro-evaluation-of-leucocyte-rich-type-1a-and-leucocyte-poor-type-3b-platelet-concentrates
#16
William R Parrish, Breana Roides, Julia Hwang, Michael Mafilios, Brooks Story, Samir Bhattacharyya
BACKGROUND: Therapeutic success of platelet-rich plasma (PRP) may vary based on the composition and preparation method. The objective of this study was to evaluate the cellular components of platelet concentrates produced by a leucocyte-rich (LR-PRP) and a leucocyte-poor PRP systems (LP-PRP). METHODS: Parameters evaluated included platelet recovery, platelet concentration, red blood cell (RBC) and white blood cell (WBC) composition, platelet growth factor release and stimulation of human tendon cell proliferation in vitro...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27900152/depa-classification-a-proposal-for-standardising-prp-use-and-a-retrospective-application-of-available-devices
#17
J Magalon, A L Chateau, B Bertrand, M L Louis, A Silvestre, L Giraudo, J Veran, F Sabatier
BACKGROUND/AIM: Significant biological differences in platelet-rich plasma (PRP) preparations have been highlighted and could explain the large variability in the clinical benefit of PRP reported in the literature. The scientific community now recommends the use of classification for PRP injection; however, these classifications are focused on platelet and leucocyte concentrations. This presents the disadvantages of (1) not taking into account the final volume of the preparation; (2) omitting the presence of red blood cells in PRP and (3) not assessing the efficiency of production...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27898509/acute-achilles-tendon-ruptures-an-update-on-treatment
#18
Anish R Kadakia, Robert G Dekker, Bryant S Ho
Acute rupture of the Achilles tendon is common and seen most frequently in people who participate in recreational athletics into their thirties and forties. Although goals of treatment have not changed in the past 15 years, recent studies of nonsurgical management, specifically functional bracing with early range of motion, demonstrate rerupture rates similar to those of tendon repair and result in fewer wound and soft-tissue complications. Satisfactory outcomes may be obtained with nonsurgical or surgical treatment...
November 24, 2016: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/27893553/healing-effects-of-platelet-rich-plasma-on-peripheral-nerve-injuries
#19
Farshid Bastami, Peyman Vares, Arash Khojasteh
Regeneration of peripheral nerve injuries (PNIs) has been a major challenging issue in regenerative medicine and tissue engineering. Inferior alveolar nerve and lingual nerve injuries are the major difficulties and complications of oral surgeries following dental implant placement, etc. The aim of this study was to systematically review the effects of platelet-rich plasma (PRP) on the regeneration of PNIs. Medline NCBI databases were searched for related articles up to and including May 2016. Being published in English papers, use of PRP in peripheral nerve regeneration, in vivo studies, and having histological evaluations was the inclusion criteria...
November 23, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27891638/regenerative-potential-of-leucocyte-and-platelet-rich-fibrin-l-prf-part-b-sinus-floor-elevation-alveolar-ridge-preservation-and-implant-therapy-a-systematic-review
#20
REVIEW
Ana B Castro, Nastaran Meschi, Andy Temmerman, Nelson Pinto, Paul Lambrechts, Wim Teughels, Marc Quirynen
AIM: To analyse the effect of Leucocyte- and Platelet Rich Fibrin (L-PRF) on bone regeneration procedures and osseointegration. MATERIALS AND METHODS: An electronic and hand search was conducted in three databases (MEDLINE, EMBASE and Cochrane). Only randomised clinical trials, written in English where L-PRF was applied in bone regeneration and implant procedures, were selected. No follow-up restrictions were applied. RESULTS: A total of 14 articles were included and processed...
November 28, 2016: Journal of Clinical Periodontology
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