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https://www.readbyqxmd.com/read/29352690/diagnostic-utility-of-histological-analysis-for-detecting-ongoing-infection-during-two-stage-revision-arthroplasty-in-patients-with-inflammatory-arthritis
#1
Jaiben George, Yaxia Zhang, Michael Jawad, Mhamad Faour, Alison K Klika, Thomas W Bauer, Carlos A Higuera
BACKGROUND: Surgeons often rely on intra-operative histology (frozen sections [FS]) to determine the next step in surgical management during the second stage (re-implantation surgery) of 2-stage revision arthroplasty. The purpose of the study is to assess the accuracy of permanent sections (PS) and FS in the diagnosis of persistent infection during re-implantation in patients with an inflammatory arthritis. METHODS: From 2001 to 2016, 47 planned second-stage revision total hip arthroplasty and total knee arthroplasty in patients with inflammatory arthritis were identified...
December 29, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29352660/clinical-significance-of-muc13-in-pancreatic-ductal-adenocarcinoma
#2
Sheema Khan, Nadeem Zafar, Shabia S Khan, Saini Setua, Stephen W Behrman, Zachary E Stiles, Murali M Yallapu, Peeyush Sahay, Hemendra Ghimire, Tomoko Ise, Satoshi Nagata, Lei Wang, Jim Y Wan, Prabhakar Pradhan, Meena Jaggi, Subhash C Chauhan
BACKGROUND: Poor prognosis of pancreatic cancer (PanCa) is associated with lack of an effective early diagnostic biomarker. This study elucidates significance of MUC13, as a diagnostic/prognostic marker of PanCa. METHODS: MUC13 was assessed in tissues using our in-house generated anti-MUC13 mouse monoclonal antibody and analyzed for clinical correlation by immunohistochemistry, immunoblotting, RT-PCR, computational and submicron scale mass-density fluctuation analyses, ROC and Kaplan Meir curve analyses...
January 15, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29352659/microwave-ablation-provides-better-survival-than-liver-resection-for-hepatocellular-carcinoma-in-patients-with-borderline-liver-function-application-of-albi-score-to-patient-selection
#3
Charing C N Chong, Kit-Fai Lee, Cheuk-Man Chu, Anthony W H Chan, John Wong, Stephen L Chan, Hon-Ting Lok, Andrew K Y Fung, Anthony K W Fong, Yue S Cheung, Simon C H Yu, Philip Johnson, Paul B S Lai
BACKGROUND: Studies comparing microwave ablation (MWA) and liver resection are lacking. This study evaluates the survival of patients with hepatocellular carcinoma (HCC) treated with liver resection or MWA and the role of Albumin-Bilirubin (ALBI) score in patient selection for treatments. METHODS: This is a retrospective analysis of patients who received curative liver resection or MWA for HCC. Propensity score matching was used at a 1:1 ratio. The value of ALBI grade for patient selection was evaluated...
January 15, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29352624/anesthetic-management-of-two-parturients-with-cerebral-palsy-and-prior-selective-dorsal-rhizotomy
#4
C M Aiudi, E E Sharpe, K W Arendt, J J Pasternak, H P Sviggum
Selective dorsal rhizotomy is a surgical spine procedure used to reduce spasticity in patients with upper motor neuron dysfunction caused by conditions such as cerebral palsy. The optimal anesthetic approach for obstetric patients who have undergone a selective dorsal rhizotomy is unknown. The use and efficacy of neuraxial anesthesia in these patients has not been described. We describe the use of neuraxial anesthesia in two patients with prior selective dorsal rhizotomy. Unless contraindicated for other reasons, a neuraxial anesthetic approach appears to be an effective option in patients with a history of a selective dorsal rhizotomy...
December 15, 2017: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/29352603/increased-single-nephron-gfr-in-normal-adults-too-much-of-a-good-thing-or-maybe-not
#5
EDITORIAL
Robert W Steiner
No abstract text is available yet for this article.
January 15, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29352576/corrigendum-to-landscape-determinants-of-spatio-temporal-patterns-of-aerosol-optical-depth-in-the-two-most-polluted-metropolitans-in-the-united-states-sci-total-environ-609-2017-1556-1565
#6
Chenghao Wang, Chuyuan Wang, Soe W Myint, Zhi-Hua Wang
No abstract text is available yet for this article.
January 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29352529/measuring-and-improving-the-quality-of-mental-health-care-a-global-perspective
#7
Amy M Kilbourne, Kathryn Beck, Brigitta Spaeth-Rublee, Parashar Ramanuj, Robert W O'Brien, Naomi Tomoyasu, Harold Alan Pincus
Mental disorders are common worldwide, yet the quality of care for these disorders has not increased to the same extent as that for physical conditions. In this paper, we present a framework for promoting quality measurement as a tool for improving quality of mental health care. We identify key barriers to this effort, including lack of standardized information technology-based data sources, limited scientific evidence for mental health quality measures, lack of provider training and support, and cultural barriers to integrating mental health care within general health environments...
February 2018: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
https://www.readbyqxmd.com/read/29352503/in-vivo-effects-of-%C3%AE-opioid-receptor-agonist-%C3%AE-opioid-receptor-antagonist-peptidomimetics-following-acute-and-repeated-administration
#8
Jessica P Anand, Kelsey E Kochan, Anthony F Nastase, Deanna Montgomery, Nicholas W Griggs, John R Traynor, Henry I Mosberg, Emily M Jutkiewicz
BACKGROUND AND PURPOSE: Mu opioid receptor (μ-receptor) agonists are used for pain management, but produce adverse effects including tolerance, dependence, and euphoria. The co-administration of a μ-receptor agonist with a delta opioid receptor (δ-receptor) antagonist has been shown to produce antinociception with reduced development of some side effects. We characterized the effects of three μ-receptor agonist/δ-receptor antagonist peptidomimetics in vivo after acute and repeated administration to determine if this profile provides a viable alternative to traditional opioid analgesics...
January 19, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29352487/disaccharide-combinations-and-the-expression-of-enolase3-and-plasma-membrane-ca2-atpase-isoform-in-sturgeon-sperm-cryopreservation
#9
M D Xi, P Li, H Du, X M Qiao, Z G Liu, Q W Wei
Acipenser sinensis and Acipenser dabryanus are critically endangered species, so germplasm conservation via cryopreservation of sperm is necessary. Disaccharides can act as membrane-impermeable cryoprotectants, and enolase3 (ENO3) and plasma membrane Ca2+ ATPase isoform (PMCA2) are proteins associated with sperm quality. We considered seven characteristics of sperm quality in cultured brood stock from A. sinensis and A. dabryanus. We tested use of sucrose or trehalose alone and in combination at different concentrations for cryopreservation of A...
January 19, 2018: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29352476/pharmacokinetic-profiles-of-the-active-metamizole-metabolites-after-four-different-routes-of-administration-in-healthy-dogs
#10
M Giorgi, B Łebkowska-Wieruszewska, A Lisowski, H Owen, A Poapolathep, T W Kim, V De Vito
Metamizole (MT), an analgesic and antipyretic drug, is rapidly hydrolyzed to the active primary metabolite 4-methylaminoantipyrine (MAA) and relatively active secondary metabolite 4-aminoantipyrine (AA). The aim of this study was to assess the pharmacokinetic profiles of MAA and AA after dose of 25 mg/kg MT by intravenous (i.v.), intramuscular (i.m.), oral (p.o.), and rectal (RC) routes in dogs. Six dogs were randomly allocated to an open, single-dose, four-treatment, four-phase, unpaired, crossover study design...
January 19, 2018: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29352458/polyhydroxybutyrate-phb-synthesis-by-spirulina-sp-leb-18-using-biopolymer-extraction-waste
#11
Cleber Klasener da Silva, Jorge Alberto Vieira Costa, Michele Greque de Morais
The reuse of waste as well as the production of biodegradable compounds has for years been the object of studies and of global interest as a way to reduce the environmental impact generated by unsustainable exploratory processes. The conversion of linear processes into cyclical processes has environmental and economic advantages, reducing waste deposition and reducing costs. The objective of this work was to use biopolymer extraction waste in the cultivation of Spirulina sp. LEB 18, for the cyclic process of polyhydroxybutyrate (PHB) synthesis...
January 20, 2018: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/29352440/the-limitations-of-standard-clinicopathologic-features-to-accurately-risk-stratify-prognosis-after-resection-of-intrahepatic-cholangiocarcinoma
#12
Fabio Bagante, Katiuscha Merath, Malcolm H Squires, Matthew Weiss, Sorin Alexandrescu, Hugo P Marques, Luca Aldrighetti, Shishir K Maithel, Carlo Pulitano, Todd W Bauer, Feng Shen, George A Poultsides, Olivier Soubrane, Guillaume Martel, B Groot Koerkamp, Alfredo Guglielmi, Endo Itaru, Timothy M Pawlik
BACKGROUND: The ability to provide accurate prognostic data after hepatectomy for intrahepatic cholangiocarcinoma (ICC) remains poor. We sought to develop and validate a nomogram to predict survival, as well as investigate the clinical implications of underestimating patients' risk of recurrence. METHODS: Patients undergoing curative-intent resection of ICC between 1990 and 2015 at 14 major hepatobiliary centers were included. Variables significant on multivariable analysis were used to construct a nomogram to predict disease-free survival (DFS)...
January 19, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29352389/detailed-t1-weighted-profiles-from-the-human-cortex-measured-in-vivo-at-3-tesla-mri
#13
Bart Ferguson, Natalia Petridou, Alessio Fracasso, Martijn P van den Heuvel, Rachel M Brouwer, Hilleke E Hulshoff Pol, René S Kahn, René C W Mandl
Studies into cortical thickness in psychiatric diseases based on T1-weighted MRI frequently report on aberrations in the cerebral cortex. Due to limitations in image resolution for studies conducted at conventional MRI field strengths (e.g. 3 Tesla (T)) this information cannot be used to establish which of the cortical layers may be implicated. Here we propose a new analysis method that computes one high-resolution average cortical profile per brain region extracting myeloarchitectural information from T1-weighted MRI scans that are routinely acquired at a conventional field strength...
January 19, 2018: Neuroinformatics
https://www.readbyqxmd.com/read/29352365/-anesthesia-problem-cards-indispensable-yet-problematic-nationwide-survey-on-experiences-from-clinical-practice
#14
M Schieren, A Böhmer, W Golbeck, J Defosse, F Wappler, H E Marcus
BACKGROUND: Anesthetic procedures may lead to severe and potentially life-threatening complications (e. g. difficult airway, allergic reactions, malignant hyperthermia). Most complications can be avoided in future anesthetic procedures with adequate preparation (e. g. awake intubation, trigger-free anesthesia). In Germany, anesthesia problem cards were introduced two decades ago to identify patients at risk and to increase patient safety by creating a standardized documentation system for anesthesia-related complications...
January 19, 2018: Der Anaesthesist
https://www.readbyqxmd.com/read/29352329/the-advantages-of-bilateral-osteotomy-over-unilateral-osteotomy-for-osteoporotic-bone-healing
#15
M Komrakova, J Fiebig, D B Hoffmann, C Krischek, W Lehmann, K M Stuermer, S Sehmisch
Most models of osteoporotic bone fractures are performed unilaterally (UL). We investigated healing of tibia osteotomy performed either UL or bilaterally (BL) in ovariectomized rats. Behavior of animals and muscle structure were assessed. Three-month-old female Sprague-Dawley rats were ovariectomized (n = 32). After 10 weeks, half the rats underwent UL osteotomy of tibia metaphysis (right limb) with plate osteosynthesis. The other rats were osteotomized BL. Half of the rats in each group received either standard pain treatment with carprofen (5 mg/kg body weight (BW), 1x/day for 2 days) or carprofen and buprenorphine (5 mg/kg BW, 1x/day and 0...
January 19, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29352320/high-level-production-and-purification-in-a-functional-state-of-an-extrasynaptic-gamma-aminobutyric-acid-type-a-receptor-containing-%C3%AE-4%C3%AE-3%C3%AE-subunits
#16
Xiaojuan Zhou, Rooma Desai, Yinghui Zhang, Wojciech J Stec, Keith W Miller, Youssef Jounaidi
The inhibitory γ-aminobutyric acid type A receptors are implicated in numerous physiological processes, including cognition and inhibition of neurotransmission, rendering them important molecular targets for many classes of drugs. Functionally, the entire GABAAR family of receptors can be subdivided into phasic, fast acting synaptic receptors, composed of α-, β- and γ-subunits, and tonic extrasynaptic receptors, many of which contain the δ-subunit in addition to α- and β-subunits. Whereas the subunit arrangement of the former group is agreed upon, that of the αβδ GABAARs remains unresolved by electrophysiological and pharmacological research...
2018: PloS One
https://www.readbyqxmd.com/read/29352281/differential-dna-methylation-and-transcription-profiles-in-date-palm-roots-exposed-to-salinity
#17
Ibtisam Al-Harrasi, Rashid Al-Yahyai, Mahmoud W Yaish
As a salt-adaptive plant, the date palm (Phoenix dactylifera L.) requires a suitable mechanism to adapt to the stress of saline soils. There is growing evidence that DNA methylation plays an important role in regulating gene expression in response to abiotic stresses, including salinity. Thus, the present study sought to examine the differential methylation status that occurs in the date palm genome when plants are exposed to salinity, and to identify salinity responsive genes that are regulated by DNA methylation...
2018: PloS One
https://www.readbyqxmd.com/read/29352279/girls-in-the-boat-sex-differences-in-rowing-performance-and-participation
#18
Kevin G Keenan, Jonathon W Senefeld, Sandra K Hunter
Men outperform women in many athletic endeavors due to physiological and anatomical differences (e.g. larger and faster muscle); however, the observed sex differences in elite athletic performance are typically larger than expected, and may reflect sex-related differences in opportunity or incentives. As collegiate rowing in the United States has been largely incentivized for women over the last 20 years, but not men, the purpose of this study was to examine sex differences in elite rowing performance over that timeframe...
2018: PloS One
https://www.readbyqxmd.com/read/29352262/microbial-regulation-of-the-l-cell-transcriptome
#19
Tulika Arora, Rozita Akrami, Ramona Pais, Linda Bergqvist, Bengt R Johansson, Thue W Schwartz, Frank Reimann, Fiona M Gribble, Fredrik Bäckhed
L cells are an important class of enteroendocrine cells secreting hormones such as glucagon like peptide-1 and peptide YY that have several metabolic and physiological effects. The gut is home to trillions of bacteria affecting host physiology, but there has been limited understanding about how the microbiota affects gene expression in L cells. Thus, we rederived the reporter mouse strain, GLU-Venus expressing yellow fluorescent protein under the control of the proglucagon gene, as germ-free (GF). Lpos cells from ileum and colon of GF and conventionally raised (CONV-R) GLU-Venus mice were isolated and subjected to transcriptomic profiling...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29352254/author-correction-long-term-carbon-sink-in-borneo-s-forests-halted-by-drought-and-vulnerable-to-edges
#20
Lan Qie, Simon L Lewis, Martin J P Sullivan, Gabriela Lopez-Gonzalez, Georgia C Pickavance, Terry Sunderland, Peter Ashton, Wannes Hubau, Kamariah Abu Salim, Shin-Ichiro Aiba, Lindsay F Banin, Nicholas Berry, Francis Q Brearley, David F R P Burslem, Martin Dančák, Stuart J Davies, Gabriella Fredriksson, Keith C Hamer, Radim Hédl, Lip Khoon Kho, Kanehiro Kitayama, Haruni Krisnawati, Stanislav Lhota, Yadvinder Malhi, Colin Maycock, Faizah Metali, Edi Mirmanto, Laszlo Nagy, Reuben Nilus, Robert Ong, Colin A Pendry, Axel Dalberg Poulsen, Richard B Primack, Ervan Rutishauser, Ismayadi Samsoedin, Bernaulus Saragih, Plinio Sist, J W Ferry Slik, Rahayu Sukmaria Sukri, Martin Svátek, Sylvester Tan, Aiyen Tjoa, Mark van Nieuwstadt, Ronald R E Vernimmen, Ishak Yassir, Petra Susan Kidd, Muhammad Fitriadi, Nur Khalish Hafizhah Ideris, Rafizah Mat Serudin, Layla Syaznie Abdullah Lim, Muhammad Shahruney Saparudin, Oliver L Phillips
The original version of this Article contained an error in the third sentence of the abstract and incorrectly read "Here, using long-term plot monitoring records of up to half a century, we find that intact forests in Borneo gained 0.43 Mg C ha-1 year-1 (95% CI 0.14-0.72, mean period 1988-2010) above-ground live biomass", rather than the correct "Here, using long-term plot monitoring records of up to half a century, we find that intact forests in Borneo gained 0.43 Mg C ha-1 year-1 (95% CI 0.14-0.72, mean period 1988-2010) in above-ground live biomass carbon"...
January 19, 2018: Nature Communications
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