Jahanzaib Khwaja, Josephine M I Vos, Tessa E Pluimers, Nicole Japzon, Aisha Patel, Simon Salter, Arjan J Kwakernaak, Rajeev Gupta, Ali Rismani, Charalampia Kyriakou, Ashutosh D Wechalekar, Shirley D'Sa
Monoclonal immunoglobulin M-associated type I cryoglobulinaemia is poorly characterised. We screened 534 patients with monoclonal IgM disorders over a 9-year period and identified 134 patients with IgM type I cryoglobulins. Of these, 76% had Waldenström macroglobulinaemia (WM), 5% had other non-Hodgkin lymphoma (NHL) and 19% had IgM monoclonal gammopathy of undetermined significance (MGUS). Clinically relevant IgM-associated disorders (including cold agglutinin disease [CAD], anti-MAG antibodies, amyloidosis and Schnitzler syndrome) coexisted in 31%, more frequently in MGUS versus WM/NHL (72% vs...
January 2024: British Journal of Haematology