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Hyperviscosity

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https://www.readbyqxmd.com/read/29890999/idelalisib-in-a-patient-with-refractory-waldenstr%C3%A3-m-s-macroglobulinemia-complicated-by-anuric-renal-failure-a-case-report
#1
M D'Aveni-Piney, M Divoux, H Busby-Venner, M Muller, J Broséus, P Feugier
BACKGROUND: Waldenström's macroglobulinemia is a rare B-cell lymphoma. The gold standard treatment for Waldenström's macroglobulinemia is an anti-CD20 antibody (rituximab) in combination with alkylating agents and dexamethasone. Treatment targeting the B-cell receptor such as ibrutinib (but not idelalisib) is currently approved for treatment of patients with relapsed or refractory Waldenström's macroglobulinemia. CASE PRESENTATION: We report a case of a 71-year-old white French man with Waldenström's macroglobulinemia who presented with acute renal failure and hyperviscosity syndrome...
June 12, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29874095/anuran-amphibians-as-comparative-models-for-understanding-extreme-dehydration-tolerance-a-negative-feedback-lymphatic-mechanism-for-blood-volume-regulation
#2
Stanley S Hillman
Anurans are the most terrestrial order of amphibians. Couple the high driving forces for evaporative loss in terrestrial environments and their low resistance to evaporation, dehydration is an inevitable stress on their water balance. Anurans have the greatest tolerances for dehydration of any vertebrate group, some species can tolerate evaporative losses up to 45% of their standard body mass. Anurans have remarkable capacities to regulate blood volume with hemorrhage and dehydration compared to mammals. Stabilization of blood volume is central to extending dehydration tolerance, since it avoids both the hypovolemic and hyperviscosity stresses on cardiac output and its consequential effects on aerobic capacity...
June 6, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29807779/use-of-intravenous-iron-in-cyanotic-patients-with-congenital-heart-disease-and-or-pulmonary-hypertension
#3
Coralie Blanche, Rafael Alonso-Gonzalez, Aitor Uribarri, Aleksander Kempny, Lorna Swan, Laura Price, Stephen J Wort, Maurice Beghetti, Konstantinos Dimopoulos
BACKGROUND: Secondary erythrocytosis is common in patients with cyanosis secondary to congenital heart disease (CHD) and/or pulmonary hypertension (PH). This compensatory mechanism aims at increasing oxygen delivery to the tissues, but it requires adequate iron stores. Optimal methods of iron supplementation in this setting remain controversial, with fears of excessive erythropoiesis and hyperviscosity symptoms. We describe our experience using intravenous ferrous carboxymaltose. METHODS AND RESULTS: 142 consecutive cyanotic patients were treated over 5...
May 19, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29766473/mr-imaging-findings-in-some-rare-neurological-complications-of-paediatric-cancer
#4
REVIEW
Tetsuhiko Okabe, Taiki Nozaki, Noriko Aida, Jay Starkey, Mikako Enokizono, Tetsu Niwa, Atsuhiko Handa, Yuji Numaguchi, Yasuyuki Kurihara
Neurological complications of paediatric cancers are a substantial problem. Complications can be primary from central nervous system (CNS) spread or secondary from indirect or remote effects of cancer, as well as cancer treatments such as chemotherapy and radiation therapy. In this review, we present the clinical and imaging findings of rare but important neurological complications in paediatric patients with cancer. Neurological complications are classified into three phases: pre-treatment, treatment and post-remission...
May 15, 2018: Insights Into Imaging
https://www.readbyqxmd.com/read/29747693/blood-hyperviscosity-identification-with-reflective-spectroscopy-of-tongue-tip-based-on-principal-component-analysis-combining-artificial-neural-network
#5
Ming Liu, Jing Zhao, XiaoZuo Lu, Gang Li, Taixia Wu, LiFu Zhang
BACKGROUND: With spectral methods, noninvasive determination of blood hyperviscosity in vivo is very potential and meaningful in clinical diagnosis. In this study, 67 male subjects (41 health, and 26 hyperviscosity according to blood sample analysis results) participate. METHODS: Reflectance spectra of subjects' tongue tips is measured, and a classification method bases on principal component analysis combined with artificial neural network model is built to identify hyperviscosity...
May 10, 2018: Biomedical Engineering Online
https://www.readbyqxmd.com/read/29742453/effect-of-p-tyrosol-on-hemorheological-parameters-and-cerebral-capillary-network-in-young-spontaneously-hypertensive-rats
#6
Mark B Plotnikov, Oleg I Aliev, Anastasia V Sidekhmenova, Alexander Y Shamanaev, Anna M Anishchenko, Tatiana I Fomina, Tatiana M Plotnikova, Alexander M Arkhipov
BACKGROUND: Many pathological mechanisms are involved in the development of arterial hypertension; disturbance of the rheological properties of blood and microvascular rarefaction are among those mechanisms. OBJECTIVE: The effect of p-tyrosol (Tyr) on hemorheological parameters and microvascularization in the cerebral cortex of spontaneously hypertensive rats (SHRs) at the stage of blood pressure rising (5-11 weeks) was studied. METHODS: Blood viscosity (BV), plasma viscosity (PV), hematocrit, erythrocyte aggregation and deformability, the oxygen transport capacity index (OTCI), and the capillary network in the cerebral cortex after the course of treatment of Tyr (50 mg/kg daily i...
May 6, 2018: Microvascular Research
https://www.readbyqxmd.com/read/29660913/gbt440-improves-red-blood-cell-deformability-and-reduces-viscosity-of-sickle-cell-blood-under-deoxygenated-conditions
#7
Kobina Dufu, Mira Patel, Donna Oksenberg, Pedro Cabrales
BACKGROUND: In sickle cell disease (SCD), polymerization of hemoglobin S (HbS) leads to the formation of rigid, non-deformable sickled RBCs. Loss of RBC deformability, sickling and irreversible membrane damage causes abnormal blood rheology, and increases viscosity which contributes to vasoocclusion and other SCD pathophysiology. GBT440 (generic name voxelotor) is a novel anti-polymerization and anti-sickling agent currently undergoing clinical evaluation for the treatment of SCD. OBJECTIVE: The purpose of this study was to determine the effects of GBT440 on deformability of sickle RBCs (SS RBCs) and the hyperviscosity of sickle cell blood (SS blood)...
April 13, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29660912/increased-plasma-viscosity-in-plasma-cell-dyscrasia-and-whole-blood-viscosity-in-polycythemia-vera
#8
Dong Woo Shin, Ja-Yoon Gu, Jun Sik Kim, Jae-Seol Jung, Dong-Yeop Shin, Youngil Koh, Inho Kim, Hyun Kyung Kim
BACKGROUND: Although hyperviscosity syndrome in plasma cell dyscrasia (PCD) and thrombosis in myeloproliferative neoplasm (MPN) are major causes of morbidity and mortality, blood viscosity measurements are often underutilized. OBJECTIVE: This study aimed to characterize whether whole blood viscosity (WBV) or plasma viscosity (PV) could be predictive of hyperviscosity syndrome in PCD and could be elevated in subgroups of MPN. METHODS: A total of 75 patients with hematologic diseases: PCD (n = 26), MPN (n = 25) including polycythemia vera (P...
April 13, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29656787/fifty-year-incidence-of-waldenstr%C3%A3-m-macroglobulinemia-in-olmsted-county-minnesota-from-1961-through-2010-a-population-based-study-with-complete-case-capture-and-hematopathologic-review
#9
Robert A Kyle, Dirk R Larson, Ellen D McPhail, Terry M Therneau, Angela Dispenzieri, Shaji Kumar, Prashant Kapoor, James R Cerhan, S Vincent Rajkumar
OBJECTIVE: To determine the incidence of Waldenström macroglobulinemia (WM) in a strictly defined geographic area over a 50-year period. PATIENTS AND METHODS: All residents of Olmsted County with a diagnosis of WM, consisting of a monoclonal IgM protein of any size and/or 10% or more lymphoplasmacytic infiltration of the bone marrow along with anemia, constitutional symptoms, hyperviscosity, lymphadenopathy, or hepatosplenomegaly requiring therapy, were identified from January 1, 1961, to December 31, 2010...
June 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29592985/caffeine-to-prevent-respiratory-failure-and-improve-outcome-in-infant-pertussis
#10
John Evered, Eric Pfeifer, Matthew Gracianette
Pertussis remains a dangerous disease for children around the world, especially for infants less than 6 months old. In this age group, high mortality and morbidity have been linked to the effects of the pertussis toxin, including lymphocytosis, pulmonary hyperviscosity and pulmonary hypertension. This paper reports on an infant with pertussis who received therapeutic caffeine. Caffeine might improve outcomes in pertussis by preventing apnoea, improving respiratory drive and decreasing pulmonary complications...
March 28, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29577910/blood-is-thicker-hyperviscosity-syndrome
#11
Rabih M Geha, Lawrence M Tierney
No abstract text is available yet for this article.
March 22, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29500854/characterization-of-microbiota-in-male-infertility-cases-uncovers-differences-in-seminal-hyperviscosity-and-oligoasthenoteratozoospermia-possibly-correlated-with-increased-prevalence-of-infectious-bacteria
#12
Catarina Monteiro, Patrícia I Marques, Bruno Cavadas, Isabel Damião, Vasco Almeida, Nuno Barros, Alberto Barros, Filipa Carvalho, Sílvia Gomes, Susana Seixas
PROBLEM: Sexually transmitted diseases and other infections of male genitourinary tract are thought to negatively impact reproductive health, affecting semen quality. Despite a possible link between bacteria and infertility, few studies attempted to characterize seminal microbiota in healthy and diseased subjects. METHODS OF THE STUDY: A high-throughput sequencing of 16S ribosomal RNA gene was performed in a cohort of infertility-related cases (N = 89) and controls (N = 29) using a pooled sample approach...
June 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29478798/therapeutic-plasma-exchange-for-hyperviscosity-syndrome-secondary-to-high-rheumatoid-factor
#13
Parvez M Lokhandwala, Maryam Shabihkhani, Paul M Ness, Evan M Bloch
Hyperviscosity syndrome (HVS) is most commonly associated with Waldenstrom's macroglobulinemia, where it may be life-threatening. HVS may also occur in autoimmune diseases; data pertaining to efficacy of therapeutic plasma exchange (TPE) in HVS arising in non-malignant gammopathy are limited. We report a case of 71-year-old female with erosive rheumatoid arthritis with profoundly elevated rheumatoid factor (57,400 IU/ml; normal <35) who presented with findings consistent with HVS: profound weakness, headache, epistaxis and plasma viscosity (8...
February 15, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29477943/the-use-of-emergency-apheresis-in-the-management-of-plasma-cell-disorders
#14
REVIEW
Sevgi Kalayoglu-Besisik
Hyperviscosity syndrome (HVS) develops most commonly in Waldenström's macroglobulinemia (WM) and multiple myeloma (MM). Plasmapheresis is the immediate therapy and very effective at relieving symptoms by removing paraprotein. The most commonly used replacement fluid is 4%-5% human albumin in physiologic saline. FFP may be used in patients with coagulation abnormalities. Plasmapheresis should be continued until acute symptoms abate. Hyperviscosity impairs the circulation in the retina and causes hemorrhages around the small retinal vessels...
February 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29476200/hyperviscosity-syndrome
#15
Guillaume Dumas, Paul Gabarre, Naike Bigé, Eric Maury
No abstract text is available yet for this article.
February 23, 2018: Intensive Care Medicine
https://www.readbyqxmd.com/read/29409138/treatment-of-semen-samples-with-%C3%AE-chymotrypsin-alters-the-expression-pattern-of-sperm-functional-proteins-a-pilot-study
#16
M K Panner Selvam, A Agarwal, R Sharma, L Samanta
Semen hyperviscosity delays the liquefaction of semen sample and is subjected to limited proteolysis by addition of α-chymotrypsin to reduce the viscosity. α-Chymotrypsin is a proteolytic enzyme involved in degradation of the proteins and polypeptides. Even though α-chymotrypsin improves the handling of hyperviscous samples, its effect on the sperm proteins is not clear. This study was aimed to evaluate the alteration in the expression of sperm functional proteins in samples treated with α-chymotrypsin...
March 2018: Andrology
https://www.readbyqxmd.com/read/29399084/blood-rheology-of-angina-pectoris-patients-with-myocardial-injury-after-ischemia-reperfusion-and-its-effect-on-thromboxane-b-2-levels
#17
Wenlong Wang, Xiaohui Huang, Yiyong Sun, Jinying Zhang
This study investigated the changes in the blood rheology of patients with angina pectoris and ischemia reperfusion injury and their effect on thromboxane B2 (TXB2 ) levels to examine their relationship. Forty patients with unstable angina pectoris who underwent elective percutaneous coronary intervention (PCI) were selected for the unstable angina group (UA group) and forty patients deemed free of coronary heart disease by coronary angiography were selected for the control group. Venous blood samples were drawn from all participants; patients in the UA group had blood drawn 1 day before and 1 day after the PCI procedure...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29386839/intensely-pruritic-papules-and-plaques-in-waldenstrom-s-macroglobulinemia
#18
Solam Lee, Noo Ri Lee, Sung Jay Choe, Beom Jun Kim, Minseob Eom, Eung Ho Choi
Waldenstrom's macroglobulinemia (WM) is lymphoplasmacytoid malignancy that affects B lymphocytes. Cutaneous involvement of WM is rare, but various cutaneous manifestations have been reported. These findings are due to various pathological processes including direct invasion of tumor cells into the skin, deposition of paraproteins, hyperviscosity syndrome, and cryoglobulinemia. A 64-year-old man presented with a 10-day history of pruritic erythematous papules and plaques on his trunk and elbows. The clinical features were suspicious for eczematous dermatitis...
February 2018: Annals of Dermatology
https://www.readbyqxmd.com/read/29225979/waldenstrom-s-macroglobulinemia-a-report-of-two-cases-one-with-severe-retinopathy-and-one-with-renal-failure
#19
Naoko Kudo, Masakatsu Usui, Yukiharu Nakabo, Ken-Ichi Yoshida, Kenji Miki, Takashi Osafune, Keisuke Nishimura, Shinsaku Imashuku
We report here two cases of Waldenstrom's macroglobulinemia (WM), one with central nervous system (CNS) symptoms and severe retinopathy and one with renal failure. In both cases, the serum IgM levels exceeded 3,000 mg/dL and monoclonal IgM-kappa was observed in the blood. At onset, Case 1, a 63-year-old female, developed CNS symptoms-namely, drowsiness and syncope. Case 2, a 58-year-old male, had nausea and dysgeusia on admission associated with renal failure, which is quite rare in patients with WM. Both patients exhibited hyperviscosity-related retinopathy, but it was particularly severe in Case 1: she suddenly lost her vision after admission...
2017: Case Reports in Hematology
https://www.readbyqxmd.com/read/29225853/a-clinical-picture-of-pulmonary-embolism-revealing-light-chain-myeloma
#20
Badia Belarj, Amine El Alaoui, Souhail Dahraoui, Jean Uwingabiye, Emmanuel Millbank Owusu, Anas Rochdi, Asmaa Biaz, Abdellah Dami, Sanae Bouhsain, Zohra Ouzzif, Nawfel Doghmi, Samira El Machtani Idrissi
We are highlighting on the particularity of a clinical picture of pulmonary embolism revealing light-chain myeloma in a 56-year-old male patient. Myeloma remains a rare affection. Even though its revelation through pulmonary embolism remains rare, it can be explained by hyperviscosity syndrome accompanying it.
December 2017: Clinical Case Reports
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