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Language Delay

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https://www.readbyqxmd.com/read/29243792/analysis-of-correlation-between-the-mild-cognitive-impairment-mci-and-level-of-adiponectin-in-elderly-patients-with-type-2-diabetes-mellitus-t2dm
#1
Z-Q Liu, M-X Zhang, J Wang, N Ding
OBJECTIVE: To investigate the correlation between the mild cognitive impairment (MCI) and serum level of adiponectin in elderly patients with Type II diabetes mellitus (T2DM), so as to provide evidence for early diagnosis of MCI and effective evaluation of the impairment of cognitive functions, thereby preventing the impairment of cognitive function as early as possible. PATIENTS AND METHODS: Clinical data were collected from 260 T2DM patients (≥ 60 years old) in Endocrine Department and 120 healthy subjects (≥ 60 years old) who underwent physical examination in our hospital between June 2015 and June 2017...
December 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29242996/personalized%C3%A2-health-monitoring%C3%A2-system-for-managing-well-being-in-rural-areas
#2
Prema Nedungadi, Akshay Jayakumar, Raghu Raman
Rural India lacks easy access to health practitioners and medical centers, depending instead on community health workers. In these areas, common ailments that are easy to manage with medicines, often lead to medical escalations and even fatalities due to lack of awareness and delayed diagnosis. The introduction of wearable health devices has made it easier to monitor health conditions and to connect doctors and patients in urban areas. However, existing initiatives have not succeeded in providing adequate health monitoring to rural and low-literate patients, as current methods are expensive, require consistent connectivity and expect literate users...
December 14, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/29235143/allostatic-load-but-not-medical-burden-predicts-memory-performance-in-late-life-bipolar-disorder
#3
REVIEW
Sophie R Vaccarino, Tarek K Rajji, Ariel G Gildengers, Sarah E S Waters, Meryl A Butters, Mahesh Menon, Daniel M Blumberger, Aristotle N Voineskos, Dielle Miranda, Benoit H Mulsant
OBJECTIVE: Older patients with bipolar disorder (BD) present with variable degrees of cognitive impairment. Over time, stress, mood episodes, and comorbidities increase the body's allostatic load. We assessed the extent to which allostatic load vs more traditional measures of medical burden account for the heterogeneity in cognition in this population. METHODS: Thirty-five older euthymic patients with BD and 30 age-equated, gender-equated, and education-equated comparison participants were administered a comprehensive assessment including a neuropsychological battery, and 9 physiological measures to determine allostatic load...
December 13, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29225339/early-speech-development-in-koolen-de-vries-syndrome-limited-by-oral-praxis-and-hypotonia
#4
Angela T Morgan, Leenke van Haaften, Karen van Hulst, Carol Edley, Cristina Mei, Tiong Yang Tan, David Amor, Simon E Fisher, David A Koolen
Communication disorder is common in Koolen de Vries syndrome (KdVS), yet its specific symptomatology has not been examined, limiting prognostic counselling and application of targeted therapies. Here we examine the communication phenotype associated with KdVS. Twenty-nine participants (12 males, 4 with KANSL1 variants, 25 with 17q21.31 microdeletion), aged 1.0-27.0 years were assessed for oral-motor, speech, language, literacy, and social functioning. Early history included hypotonia and feeding difficulties...
December 11, 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29225124/time-delays-in-the-diagnosis-and-treatment-of-malaria-in-non-endemic-countries-a-systematic-review
#5
REVIEW
Hamad Bastaki, Jessica Carter, Louise Marston, Jackie Cassell, Greta Rait
BACKGROUND: Delays in diagnosis and treatment for malaria are associated with an increased risk for severe disease and mortality. Identifying the extent of patient and health system delay can provide a benchmark against which interventions to reduce delays can be measured. METHODS: We performed an electronic search in PubMed, EMBASE, Web of Science and LILACS for studies reporting time to diagnosis and treatment after return from travel, onset of symptoms and seeking healthcare in non-endemic countries...
December 7, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29223594/femoral-neck-fractures-after-removal-of-hardware-in-healed-trochanteric-fractures
#6
REVIEW
Antonio Barquet, Peter V Giannoudis, Andrés Gelink
INTRODUCTION: Hardware removal in healed trochanteric fractures (TF) in the absence of infection or significant mechanical complications is rarely indicated. However, in patients with persistent pain, prominent material and discomfort in the activities of daily living, the implant is eventually removed. Publications of ipsilateral femoral neck fracture after removal of implants from healed trochanteric fractures (FNFARIHTF) just because of pain or discomfort are rare. The purpose of this systematic review of the literature is to report on the eventual risk factors, the mechanisms, the clinical presentation, and frequency, and to pay special emphasis in their prevention...
December 2017: Injury
https://www.readbyqxmd.com/read/29221530/parenting-practices-and-associations-with-development-delays-among-young-children-in-dominican-republic
#7
Omolara Thomas Uwemedimo, Afrin Howlader, Giselina Pierret
BACKGROUND: According to the World Health Organization, >200 million children in low- and middle-income countries experience developmental delays. However, household structure and parenting practices have been minimally explored as potential correlates of developmental delay in low- and middle-income countries, despite potential as areas for intervention. OBJECTIVE: The objective of the study was to examine associations of developmental delays with use of World Health Organization-recommended parenting practices among a clinic-based cohort of children aged 6-60 months attending in La Romana, Dominican Republic...
May 2017: Annals of Global Health
https://www.readbyqxmd.com/read/29215166/effectiveness-of-platelet-rich-plasma-therapy-in-wound-healing-of-pilonidal-sinus-surgery-a-comprehensive-systematic-review-and-meta-analysis
#8
Shayan Mostafaei, Fatemeh Norooznezhad, Saeed Mohammadi, Amir Hossein Norooznezhad
BACKGROUND: Pilonidal disease (PD) is a chronic situation which may cause pain, discomfort, inflammation, discharges, and inability to do daily routines. Among two main methods of surgery, open healing is preferred by surgeons since it associates with lower risk of recurrence; however, it could complicate the wound condition by delaying the healing process. METHODS: For this meta-analysis, a search in Medline, Embase and Scopus was performed in June 2017 with no restrictions placed on the publication date or languages...
December 7, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29215027/altered-human-voice-processing-in-the-frontal-cortex-and-a-developmental-language-delay-in-3-to-5-year-old-children-with-autism-spectrum-disorder
#9
Yuko Yoshimura, Mitsuru Kikuchi, Norio Hayashi, Hirotoshi Hiraishi, Chiaki Hasegawa, Tetsuya Takahashi, Manabu Oi, Gerard B Remijn, Takashi Ikeda, Daisuke N Saito, Hirokazu Kumazaki, Yoshio Minabe
The inferior frontal and superior temporal areas in the left hemisphere are crucial for human language processing. In the present study, we investigated the magnetic mismatch field (MMF) evoked by voice stimuli in 3- to 5-year-old typically developing (TD) children and children with autism spectrum disorder (ASD) using child-customized magnetoencephalography (MEG). The children with ASD exhibited significantly decreased activation in the left superior temporal gyrus compared with the TD children for the MMF amplitude...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29209697/false-belief-development-in-children-who-are-hard-of-hearing-compared-with-peers-with-normal-hearing
#10
Elizabeth A Walker, Sophie E Ambrose, Jacob Oleson, Mary Pat Moeller
Purpose: This study investigates false belief (FB) understanding in children who are hard of hearing (CHH) compared with children with normal hearing (CNH) at ages 5 and 6 years and at 2nd grade. Research with this population has theoretical significance, given that the early auditory-linguistic experiences of CHH are less restricted compared with children who are deaf but not as complete as those of CNH. Method: Participants included CHH and CNH who had completed FB tasks as part of a larger multicenter, longitudinal study on outcomes of children with mild-to-severe hearing loss...
December 6, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/29208076/improving-diagnostic-communication-in-dementia
#11
Sheung-Tak Cheng, Linda C W Lam
In many countries around the world, owing to the lack of specialists and equipment, delay up to a few years in help-seeking and getting diagnostic examinations for dementia is not uncommon (Sayegh and Knight, 2013), and this situation is considerably more serious in "atypical dementias" due to the challenge they present for differential diagnosis. For instance, a survey in the USA showed that misdiagnosis was common in patients with Lewy body dementia who, on average, saw at least three physicians over a year's time or more before getting the proper diagnosis (Lewy Body Dementia Association, 2010)...
December 6, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29206229/pssalib-the-partial-propensity-stochastic-chemical-network-simulator
#12
Oleksandr Ostrenko, Pietro Incardona, Rajesh Ramaswamy, Lutz Brusch, Ivo F Sbalzarini
Chemical reaction networks are ubiquitous in biology, and their dynamics is fundamentally stochastic. Here, we present the software library pSSAlib, which provides a complete and concise implementation of the most efficient partial-propensity methods for simulating exact stochastic chemical kinetics. pSSAlib can import models encoded in Systems Biology Markup Language, supports time delays in chemical reactions, and stochastic spatiotemporal reaction-diffusion systems. It also provides tools for statistical analysis of simulation results and supports multiple output formats...
December 4, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29202529/-characteristics-of-cognitive-function-behavioral-and-psychological-symptoms-in-patients-with-alzheimer-s-disease-versus-behavioral-variant-frontotemporal-dementia
#13
L L Zhang, Y Wang, Y Cheng, N Zhang
Objective: To compare the differences in cognitive function and behavioral and psychological symptoms between patients with Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD). Methods: Thirty-six AD patients and 20 bvFTD patients at mild-to-moderate stage, who were biomarker-confirmed by positron emission tomography (PET), were assessed with a neuropsychological battery and neuropsychiatry inventory (NPI). Cognitive domains, including memory, language, information processing speed and executive function, and behavioral and psychological symptoms were assessed and compared...
December 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29201824/assessment-of-preterm-infants-using-the-bayley-iii-scales-in-korea
#14
Sung Ho Ahn, Soo A Kim
Objective: To assess the well-being of preterm newborns using the Bayley-III scales in a Korean-based population, and to evaluate the perinatal risk factors influencing developmental outcome. Methods: Using the Bayley-III scales, we assessed 120 preterm infants who were referred for evaluation of neurodevelopmental performance. We subdivided them into an extremely preterm group (n=18) and a very/moderate to late preterm group (n=102). Bayley-III mean scores and the rate of infants showing a delay were compared for both groups...
October 2017: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29201823/speech-and-linguistic-features-of-children-with-articulation-disorder
#15
Jiyong Kim, Seong Woo Kim, Ha Ra Jeon, Mee Ryung Woo, Hyo In Kim
Objective: To analyze speech and linguistic features in children with articulation disorder characterized by consonant and vowel phonological errors. Methods: Between February 2007 and June 2015, 117 children who showed articulation disorder were selected for the study. Based on comprehensive speech and language assessments, the subjects were classified into articulation dysfunction (AD), or AD overlapping with language delay. Detailed information of articulation, including percentage of consonants correct (PCC) and normal percentage of variable consonants derived from the Assessment of Phonology and Articulation for Children test, were compared between the two groups...
October 2017: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29193617/clinical-and-molecular-characterization-of-an-emerging-chromosome-22q13-31-microdeletion-syndrome
#16
Pietro Palumbo, Maria Accadia, Maria P Leone, Teresa Palladino, Raffaella Stallone, Massimo Carella, Orazio Palumbo
Microdeletion of chromosome 22q13.31 is a very rare condition. Fourteen patients have been annotated in public databases but, to date, a clinical comparison has not been done and, consequently, a specific phenotype has not been delineated yet. We describe a patient showing neurodevelopmental disorders, dysmorphic features, and multiple congenital anomalies in which SNP array analysis revealed an interstitial 3.15 Mb de novo microdeletion in the 22q13.31 region encompassing 21 RefSeq genes and seven non-coding microRNAs...
November 28, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29191588/timeliness-of-access-to-lung-cancer-diagnosis-and-treatment-a-scoping-literature-review
#17
REVIEW
Margo M Jacobsen, Sophie C Silverstein, Michael Quinn, Leo B Waterston, Christian A Thomas, James C Benneyan, Paul K J Han
The Institute of Medicine recently called for increased understanding of and commitment to timely care. Lung cancer can be difficult to diagnose, resulting in delays that may adversely affect survival; rapid diagnosis and treatment therefore is critical for enabling improved patient outcomes. This scoping review provides an update on timeliness of lung cancer care over the past decade. We searched PubMed for English-language articles published from 2007 to 2016 that report wait time intervals related to diagnosis and treatment of lung cancer...
October 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29189610/early-childhood-neurodevelopmental-outcomes-in-infants-exposed-to-infectious-syphilis-in-utero
#18
Valsan P Verghese, Leonora Hendson, Ameeta Singh, Tamara Guenette, Jennifer Gratrix, Joan L Robinson
BACKGROUND: There are minimal neurodevelopmental follow-up data for infants exposed to syphilis in-utero. METHODS: This is an inception cohort study of infants exposed to syphilis in utero. We reviewed women with reactive syphilis serology in pregnancy or at delivery in Edmonton (Canada), 2002 through 2010 and describe the neurodevelopmental outcomes of children with and without congenital syphilis. RESULTS: There were 39 births to women with reactive syphilis serology, 9 of whom had late latent syphilis (n=4), stillbirths (n=2) or early neonatal deaths (n=3), leaving 30 survivors of which 11 with and 7 without congenital syphilis had neurodevelopmental assessment...
November 15, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29189431/psychosocial-outcomes-in-long-term-cochlear-implant-users
#19
Irina Castellanos, William G Kronenberger, David B Pisoni
OBJECTIVES: The objectives of this study were to investigate psychosocial outcomes in a sample of prelingually deaf, early-implanted children, adolescents, and young adults who are long-term cochlear implant (CI) users and to examine the extent to which language and executive functioning predict psychosocial outcomes. DESIGN: Psychosocial outcomes were measured using two well-validated, parent-completed checklists: the Behavior Assessment System for Children and the Conduct Hyperactive Attention Problem Oppositional Symptom...
November 20, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/29189420/neostigmine-based-reversal-of-intermediate-acting-neuromuscular-blocking-agents-to-prevent-postoperative-residual-paralysis-a-systematic-review
#20
Najat Tajaate, Jan-Uwe Schreiber, Thomas Fuchs-Buder, Yvonne Jelting, Peter Kranke
BACKGROUND: Neostigmine is widely used to antagonise residual paralysis. Over the last decades, the benchmark of acceptable neuromuscular recovery has increased progressively to a train-of-four (TOF) ratio of at least 0.9. Raising this benchmark may impact on the efficacy of neostigmine. OBJECTIVE(S): The systematic review evaluates the efficacy of neostigmine to antagonise neuromuscular block to attain a TOF ratio of at least 0.9. DESIGN: We performed a systematic search of the literature from January 1992 to December 2015...
November 20, 2017: European Journal of Anaesthesiology
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