keyword
MENU ▼
Read by QxMD icon Read
search

Language Delay

keyword
https://www.readbyqxmd.com/read/29439369/repetitive-sessions-of-tdcs-to-improve-naming-in-post-stroke-aphasia-insights-from-an-individual-patient-data-ipd-meta-analysis
#1
Charlotte Rosso, Céline Arbizu, Claire Dhennain, Jean-Charles Lamy, Yves Samson
OBJECTIVES: Small clinical trials reported that repetitive sessions of tDCS could improve naming abilities in post-stroke aphasia. However, systematic meta-analyses found no effect, but all of these analyses pooled data from both single and repetitive sessions at the group level. The aim of this paper was to perform a meta-analysis based on individual patient data to explore the effects of repetitive tDCS sessions on naming in post-stroke aphasia and in prespecified subgroups. METHODS: We searched for published sham-controlled trials using the keywords "aphasia OR language" AND "transcranial direct current stimulation OR tDCS" AND "stroke"...
2018: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/29437499/primer-on-state-statutory-mandates-of-third-party-orthodontic-coverage-for-cleft-palate-and-craniofacial-care-in-the-united-states
#2
Kristin D Pfeifauf, Alison Synder-Warwick, Gary B Skolnick, Sybill D Naidoo, Richard J Nissen, Kamlesh B Patel
Provision and timing of orthodontic treatment is a crucial part of comprehensive cleft palate and craniofacial care. Some states statutorily mandate orthodontic coverage for the medically necessary care of cleft palate and craniofacial anomalies. However, application of the medically necessary standard varies broadly. Disputes over medical necessity lead to orthodontic coverage denials and surgical intervention delays. Provider-friendly statutory definitions of medical necessity enable patients and providers to avoid such hurdles...
March 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29436854/feasibility-of-event-related-potential-erp-biomarker-use-to-study-effects-of-mother-s-voice-exposure-on-speech-sound-differentiation-of-preterm-infants
#3
Olena D Chorna, Ellyn L Hamm, Hemang Shrivastava, Nathalie L Maitre
Atypical maturation of auditory neural processing contributes to preterm-born infants' language delays. Event-related potential (ERP) measurement of speech-sound differentiation might fill a gap in treatment-response biomarkers to auditory interventions. We evaluated whether these markers could measure treatment effects in a quasi-randomized prospective study. Hospitalized preterm infants in passive or active, suck-contingent mother's voice exposure groups were not different at baseline. Post-intervention, the active group had greater increases in/du/-/gu/differentiation in left frontal and temporal regions...
2018: Developmental Neuropsychology
https://www.readbyqxmd.com/read/29429782/long-term-treatment-of-niemann-pick-type-c1-disease-with-intrathecal-2-hydroxypropyl-%C3%AE-cyclodextrin
#4
Elizabeth Berry-Kravis, Jamie Chin, Anne Hoffmann, Amy Winston, Robin Stoner, Lisa LaGorio, Katherine Friedmann, Mariana Hernandez, Daniel S Ory, Forbes D Porter, Joan A O'Keefe
BACKGROUND: Intrathecal 2-hydoxypropyl-β-cyclodextrin has been found to mobilize cholesterol, extend life, reduce cerebellar pathology, and delay onset of ataxia in the mouse and cat models of Niemann-Pick disease, type C1, a clinically variable progressive and ultimately fatal neurodegenerative storage disorder characterized by endolysosomal accumulation of unesterified cholesterol. OBJECTIVE: In this study, the long-term effects of intrathecal 2-hydoxypropyl-β-cyclodextrin treatment for 2...
January 8, 2018: Pediatric Neurology
https://www.readbyqxmd.com/read/29429769/neurodevelopmental-outcomes-of-infants-with-esophageal-atresia-and-tracheoesophageal-fistula
#5
Wegdan Mawlana, Paul Zamiara, Hilary Lane, Margaret Marcon, Eveline Lapidus-Krol, Priscilla Pl Chiu, Aideen M Moore
BACKGROUND: Esophageal atresia with or without tracheoesophageal fistula (EA/TEF) is a complex disorder, and most outcome data are confined to mortality and feeding-related morbidities. Our objective was to examine mortality, growth and neurodevelopmental outcomes in a large recent cohort of infants with EA/TEF. METHODS: Single center study of EA/TEF infants referred from January 2000 to December 2015. Data collected included associated defects, neonatal morbidity and mortality and growth and neurodevelopmental outcomes at age 12-36months...
January 31, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29429008/from-using-tools-to-using-language-in-infant-siblings-of-children-with-autism
#6
Laura Sparaci, Jessie B Northrup, Olga Capirci, Jana M Iverson
Forty-one high-risk infants (HR) with an older sibling with autism spectrum disorder (ASD) were observed longitudinally at 10, 12, 18 and 24 months of age during a tool use task in a play-like scenario. Changes in grasp types and functional actions produced with a spoon were assessed during elicited tool use. Outcome and vocabulary measures were available at 36 months, distinguishing: 11 HR-ASD, 15 HR-language delay and 15 HR-no delay. Fewer HR-ASD infants produced grasp types facilitating spoon use at 24 months and functional actions at 10 months than HR-no delay...
February 10, 2018: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29427542/school-dysfunction-in-youth-with-autistic-spectrum-disorder-in-taiwan-the-effect-of-subtype-and-adhd
#7
Huey-Ling Chiang, Wei-Chih Kao, Mei-Chun Chou, Wen-June Chou, Yen-Nan Chiu, Yu-Yu Wu, Susan Shur-Fen Gau
School dysfunction is observed in youths with autism spectrum disorder (ASD), but the factors moderating their school dysfunction have not been well explored. This study investigated school functions in youths with ASD in Taiwan, stratified by personal characteristics including demographics, ASD subtypes, intelligence profiles, and the presence of attention-deficit hyperactivity disorder (ADHD). We recruited 160 youths (aged 6-18 years, 87.5% boys) with a clinical diagnosis of ASD and 160 age and gender-matched typically developing (TD) youths...
February 10, 2018: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/29427070/motivation-among-pre-intermediate-iranian-language-learners-from-explicit-knowledge-toward-implicit-syntactic-development
#8
Amirabbas Rafiee Fazel, Mehdi Latifi, M Raouf Moini
The variable success in learning a second language (L2) may be best explained by varying degrees of motivation. This study investigated whether individual differences in appraisal dimensions of motivation explained explicit and implicit syntactic knowledge. Participants learned three syntactic structures under implicit and explicit training conditions. They also completed two motivation questionnaires before instruction. Syntactic development was assessed at early and late stages of acquisition. Results indicated superior performance on the tests of explicit knowledge, but a limited effect for the role of motivation in its development...
February 9, 2018: Journal of Psycholinguistic Research
https://www.readbyqxmd.com/read/29427049/favourable-outcome-in-a-child-with-symptomatic-diagnosis-of-glutaric-aciduria-type-1-despite-vertical-hiv-infection-and-minor-head-trauma
#9
Angeline Thomas, Els F M Dobbels, Priscilla E Springer, Christelle Ackermann, Mark F Cotton, Barbara Laughton
The first case of Glutaric aciduria Type 1(GA1) in an African child was reported in 2001. GA1 has a prevalence of 1:5000 in black South Africans. Although early diagnosis is essential for a favourable outcome, newborn screening is not routine in South Africa where an estimated 320,000 children have HIV infection. Neurodevelopmental delay and encephalopathy are complications of both HIV and GA1. In such a setting it is important to recognise that HIV and GA1 can occur simultaneously. We present an HIV-infected South African male child of Xhosa descent with macrocephaly who commenced combination antiretroviral therapy (ART) at 8 weeks of age in a clinical trial which included a neurodevelopmental sub-study...
February 9, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29423971/two-de-novo-novel-mutations-in-one-shank3-allele-in-a-patient-with-autism-and-moderate-intellectual-disability
#10
Wenmiao Zhu, Jianli Li, Stella Chen, Jinglan Zhang, Francesco Vetrini, Alicia Braxton, Christine M Eng, Yaping Yang, Fan Xia, Kory L Keller, Leila Okinaka-Hu, Chung Lee, J Lloyd Holder, Weimin Bi
SHANK3 encodes for a scaffolding protein that links neurotransmitter receptors to the cytoskeleton and is enriched in postsynaptic densities of excitatory synapses. Deletions or mutations in one copy of the SHANK3 gene cause Phelan-McDermid syndrome, also called 22q13.3 deletion syndrome, a neurodevelopmental disorder with common features including global developmental delay, absent to severely impaired language, autistic behavior, and minor dysmorphic features. By whole exome sequencing, we identified two de novo novel variants including one frameshift pathogenic variant and one missense variant of unknown significance in a 14-year-old boy with delayed motor milestones, delayed language acquisition, autism, intellectual disability, ataxia, progressively worsening spasticity of the lower extremities, dysmorphic features, short stature, microcephaly, failure to thrive, chronic constipation, intrauterine growth restriction, and bilateral inguinal hernias...
February 9, 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29423073/cognition-serum-bdnf-levels-and-bdnf-val66met-polymorphism-in-type-2-diabetes-patients-and-healthy-controls
#11
Yan-Feng Zhen, Xing-Yu Liu, Dong-Hao Zhou, Xiangdong Du, Guangzhong Yin, Yingyang Zhang, Hui Fang, Gang Xu, Jair C Soares, Xiang Yang Zhang
Background and aims: Type 2 diabetes (T2DM) is associated with cognitive deficits. However, their pathophysiological mechanisms are still unknown. Recent study suggests that brain-derived neurotrophic factor (BDNF) is correlated with cognitive deficits in T2DM patients. This study was to determine whether altered serum BDNF levels and cognitive deficits depended on the BDNF Val66Met polymorphism in T2DM. Results: The BDNF Val66Met polymorphism may not contribute directly to the susceptibility to T2DM...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29415681/prenatal-and-perinatal-risks-for-late-language-emergence-in-a-population-level-sample-of-twins-at-age-2
#12
Catherine L Taylor, Mabel L Rice, Daniel Christensen, Eve Blair, Stephen R Zubrick
BACKGROUND: Late Language Emergence (LLE) in the first two years of life is one of the most common parental concerns about child development and reasons for seeking advice from health professionals. LLE is much more prevalent in twins (38%) than singletons (20%). In studies of language development in twins without overt disability, adverse prenatal and perinatal environments have been reported to play a lesser role in the etiology of LLE than adverse postnatal environments. However, there is a lack of population-level evidence about prenatal and perinatal risk factors for LLE in twins...
February 7, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29407637/planning-to-speak-in-l1-and-l2
#13
Agnieszka E Konopka, Antje Meyer, Tess A Forest
The leading theories of sentence planning - Hierarchical Incrementality and Linear Incrementality - differ in their assumptions about the coordination of processes that map preverbal information onto language. Previous studies showed that, in native (L1) speakers, this coordination can vary with the ease of executing the message-level and sentence-level processes necessary to plan and produce an utterance. We report the first series of experiments to systematically examine how linguistic experience influences sentence planning in native (L1) speakers (i...
January 25, 2018: Cognitive Psychology
https://www.readbyqxmd.com/read/29397615/-clinical-features-and-gene-mutation-analysis-of-patients-with-niemann-pick-disease-type-c
#14
S C Ren, Z X Tian, Y X Deng, Y J Wang, X J Wu, Y Z Zhang, B Q Gao
Objective: To analyze the clinical manifestations, therapeutic efficacy, prognosis and characteristics of NPC1 mutation in Chinese patients with Niemann-Pick disease type C(NPC). Methods: Ten unrelated Chinese NPC patients were diagnosed by NPC1 mutation analysis from July 2013 to February 2017 in Beijing Tian Tan Hospital of Capital Medical University. Clinical data of 10 cases were analyzed retrospectively which included clinical manifestations, laboratory results and NPC1 gene mutation features, and a series of follow-up were carried out about therapeutic efficacy and prognosis...
January 23, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29395617/unilateral-congenital-hearing-loss-in-children-challenges-and-potentials
#15
REVIEW
Astrid van Wieringen, An Boudewyns, Anouk Sangen, Jan Wouters, Christian Desloovere
The estimated incidence of sensorineural hearing impairment (>40 dB HL) at birth is 1.86 per 1000 newborns in developed countries and 30-40% of these are unilateral. Profound sensorineural unilateral hearing impairment or single sided deafness (SSD) can be treated with a cochlear implant. However, this treatment is costly and invasive and unnecessary in the eyes of many. Very young children with SSD often do not exhibit language and cognitive delays and it is hard to imagine that neurocognitive skills will present difficulties with one good ear...
January 30, 2018: Hearing Research
https://www.readbyqxmd.com/read/29395280/pediatric-cochlear-implant-soft-failure
#16
David Ulanovski, Joseph Attias, Meirav Sokolov, Tali Greenstein, Eyal Raveh
PURPOSE: Hard cochlear implant failures are diagnosed by objective tests whereas soft failures are suspected on the basis of clinical signs and symptoms. This study reviews our experience with children in tertiary pediatric medical center who underwent revision cochlear implantation, with emphasis on soft failures. MATERIALS AND METHODS: Children (age<18years) who underwent revision cochlear implantation from 2000 to 2012 were identified by database search. Pre- and post-explantation data were collected...
December 19, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29395075/otud7a-knockout-mice-recapitulate-many-neurological-features-of-15q13-3-microdeletion-syndrome
#17
Jiani Yin, Wu Chen, Eugene S Chao, Sirena Soriano, Li Wang, Wei Wang, Steven E Cummock, Huifang Tao, Kaifang Pang, Zhandong Liu, Fred A Pereira, Rodney C Samaco, Huda Y Zoghbi, Mingshan Xue, Christian P Schaaf
15q13.3 microdeletion syndrome is characterized by a wide spectrum of neurodevelopmental disorders, including developmental delay, intellectual disability, epilepsy, language impairment, abnormal behaviors, neuropsychiatric disorders, and hypotonia. This syndrome is caused by a deletion on chromosome 15q, which typically encompasses six genes. Here, through studies on OTU deubiquitinase 7A (Otud7a) knockout mice, we identify OTUD7A as a critical gene responsible for many of the cardinal phenotypes associated with 15q13...
February 1, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29391390/ulk4-regulates-gabaergic-signaling-and-anxiety-related-behavior
#18
Min Liu, Marie Fitzgibbon, Yanqin Wang, Jamie Reilly, Xiaohong Qian, Timothy O'Brien, Steve Clapcote, Sanbing Shen, Michelle Roche
Excitation/inhibition imbalance has been proposed as a fundamental mechanism in the pathogenesis of neuropsychiatric and neurodevelopmental disorders, in which copy number variations of the Unc-51 like kinase 4 (ULK4) gene encoding a putative Serine/Threonine kinase have been reported in approximately 1/1000 of patients suffering pleiotropic clinical conditions of schizophrenia, depression, autistic spectrum disorder (ASD), developmental delay, language delay, intellectual disability, or behavioral disorder...
February 2, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29389179/improving-the-global-identification-of-bipolar-spectrum-disorders-meta-analysis-of-the-diagnostic-accuracy-of-checklists
#19
Eric A Youngstrom, Gregory A Egerton, Jacquelynne Genzlinger, Lindsey K Freeman, Sabeen H Rizvi, Anna Van Meter
Shifting definitions and differences in the conceptualization of bipolar disorders have contributed to long diagnostic delays, poor reliability, and inconsistent findings. Rating scales are independent of clinical judgment and offer a reliable way to assess manic symptoms, making them good tools to improve both clinical and research diagnoses of bipolar disorder. However, there are dozens of candidates, with few obvious distinguishing characteristics, making it difficult to select one. Our goal was to metaanalyze the diagnostic accuracy of rating scales designed to identify [hypo]manic symptoms...
February 1, 2018: Psychological Bulletin
https://www.readbyqxmd.com/read/29383823/perthes-disease-a-new-finding-in-floating-harbor-syndrome
#20
Donatella Milani, Giulietta Scuvera, Marta Gatti, Gianluca Tolva, Francesca Bonarrigo, Susanna Esposito, Cristina Gervasini
Floating-Harbor Syndrome (FHS; OMIM #136140) is an ultra-rare autosomal dominant genetic condition characterized by expressive language delay, short stature with delayed bone mineralization, a triangular face with a prominent nose, and deep-set eyes, and hand anomalies. First reported in 1973, FHS is associated with mutations in the SRCAP gene, which encodes SNF2-related CREBBP activator protein. Mutations in the CREBBP gene cause Rubinstein-Taybi Syndrome (RSTS; OMIM #180849, #613684), another rare disease characterized by broad thumbs and halluces, facial dysmorphisms, short stature, and intellectual disability, which has a phenotypic overlap with FHS...
January 31, 2018: American Journal of Medical Genetics. Part A
keyword
keyword
20959
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"