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https://www.readbyqxmd.com/read/28913878/do-pancreatic-cancer-and-chronic-pancreatitis-share-the-same-genetic-risk-factors-a-pancreatic-disease-research-pandora-consortium-investigation
#1
Daniele Campa, Manuela Pastore, Gabriele Capurso, Thilo Hackert, Milena Di Leo, Jakob R Izbicki, Kay-Tee Khaw, Domenica Gioffreda, Juozas Kupcinskas, Claudio Pasquali, Peter Macinga, Rudolf Kaaks, Serena Stigliano, Petra H Peeters, Timothy J Key, Renata Talar-Wojnarowska, Pavel Vodicka, Roberto Valente, Yogesh K Vashist, Roberto Salvia, Ioannis Papaconstantinou, Yasuhiro Shimizu, Chiara Valsuani, Carlo Federico Zambon, Maria Gazouli, Irena Valantiene, Willem Niesen, Beatrice Mohelnikova-Duchonova, Kazuo Hara, Pavel Soucek, Ewa Malecka-Panas, H Bas Bueno-De-Mesquita, Theron Johnson, Herman Brenner, Francesca Tavano, Paola Fogar, Hidemi Ito, Cosimo Sperti, Katja Butterbach, Anna Latiano, Angelo Andriulli, Giulia Martina Cavestro, Olivier R C Busch, Frederike Dijk, William Greenhalf, Keitaro Matsuo, Carlo Lombardo, Oliver Strobel, Anna-Katharina König, Katarina Cuk, Hendrik Strothmann, Verena Katzke, Maurizio Cantore, Andrea Mambrini, Martin Oliverius, Raffaele Pezzilli, Stefano Landi, Federico Canzian
Pancreatic ductal adenocarcinoma (PDAC) is a very aggressive tumor with a five-year survival of less than 6%. Chronic pancreatitis (CP), an inflammatory process in of the pancreas, is a strong risk factor for PDAC. Several genetic polymorphisms have been discovered as susceptibility loci for both CP and PDAC. Since CP and PDAC share consistent number of epidemiologic risk factors, the aim of this study was to investigate whether specific CP risk loci also contribute to PDAC susceptibility. We selected five common SNPs (rs11988997, rs379742, rs10273639 rs2995271 and rs12688220) that were identified as susceptibility markers for CP and analyzed them in 2,914 PDAC cases, 356 CP cases and 5,596 controls retrospectively collected in the context of the international PANDoRA consortium...
September 15, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28906483/possible-under-treatment-of-women-in-poland-with-crohn-s-disease-a-subgroup-analysis-from-a-prospective-multicenter-study-of-the-use-of-anti-tnfs
#2
Piotr Eder, Maria Kłopocka, Maria Wiśniewska-Jarosińska, Renata Talar-Wojnarowska, Dariusz Maj, Iga Detka-Kowalska, Jarosław Kierkuś, Andrzej Śliwczyński, Paulina Wieszczy, Marek Bugajski, Maciej Gonciarz, Edyta Zagórowicz
No abstract text is available yet for this article.
August 31, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28905221/comparison-between-percutaneous-and-open-reduction-for-treating-paediatric-talar-neck-fractures
#3
Xu Zhang, Xinzhong Shao, Yadong Yu, Yingzhe Zhang, Guizheng Zhang, Dehu Tian
BACKGROUND: The purpose of the study was to introduce percutaneous reduction and fixation of paediatric talar neck fractures. The study also included a comparison between the technique and the conventional open surgery. METHODS: From October 2003 to May 2013, 23 children (group A) with closed two-part talar neck fractures were treated with percutaneous reduction. For comparison, another group of 26 children (group B) were treated with the conventional open surgery...
September 13, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28891713/effect-of-preoperative-deformity-on-arthroscopic-and-open-ankle-fusion-outcomes
#4
Timo Schmid, Fabian Krause, Murray J Penner, Andrea Veljkovic, Alastair S E Younger, Kevin Wing
INTRODUCTION: Coronal deformity is considered a relative contraindication for arthroscopic ankle fusion. This study assessed whether preoperative coronal ankle joint deformity influenced the outcome of arthroscopic ankle fusion. METHODS: Ninety-seven patients had 62 arthroscopic and 35 open ankle fusions between 2005 and 2012. Clinical outcomes were prospectively recorded with use of the Ankle Osteoarthritis Scale (AOS) and Ankle Arthritis Scale (AAS) preoperatively and at 6, 12, and 24 months and final follow-up...
September 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28882059/mri-evaluation-of-ligaments-and-tendons-of-foot-arch-in-talar-dome-osteochondral-lesions
#5
Ali Koç, Özgür Karabiyik
Background There are no publications in literature describing an association between disorders of the ligaments and tendons supporting the foot arch and osteochondral lesions of the talus (OCLT). We believe there may be a correlation between the damage of these structures. Purpose To investigate the pathologies of main ligaments and tendons that support the foot arch in sprained ankles, by reviewing magnetic resonance imaging (MRI) studies and comparing the results in two groups of patients, with and without OCLT...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28874272/postcrania-of-the-most-primitive-euprimate-and-implications-for-primate-origins
#6
Doug M Boyer, Séverine Toussaint, Marc Godinot
The fossil record of early primates is largely comprised of dentitions. While teeth can indicate phylogenetic relationships and dietary preferences, they say little about hypotheses pertaining to the positional behavior or substrate preference of the ancestral crown primate. Here we report the discovery of a talus bone of the dentally primitive fossil euprimate Donrussellia provincialis. Our comparisons and analyses indicate that this talus is more primitive than that of other euprimates. It lacks features exclusive to strepsirrhines, like a large medial tibial facet and a sloping fibular facet...
October 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/28874270/the-evolution-of-the-platyrrhine-talus-a-comparative-analysis-of-the-phenetic-affinities-of-the-miocene-platyrrhines-with-their-modern-relatives
#7
Thomas A Püschel, Justin T Gladman, René Bobe, William I Sellers
Platyrrhines are a diverse group of primates that presently occupy a broad range of tropical-equatorial environments in the Americas. However, most of the fossil platyrrhine species of the early Miocene have been found at middle and high latitudes. Although the fossil record of New World monkeys has improved considerably over the past several years, it is still difficult to trace the origin of major modern clades. One of the most commonly preserved anatomical structures of early platyrrhines is the talus. This work provides an analysis of the phenetic affinities of extant platyrrhine tali and their Miocene counterparts through geometric morphometrics and a series of phylogenetic comparative analyses...
October 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/28865575/single-step-arthroscopic-repair-with-cell-free-polymer-based-scaffold-in-osteochondral-lesions-of-the-talus-clinical-and-radiological-results
#8
Ulunay Kanatlı, Ali Eren, Toygun Kağan Eren, Abdurrahman Vural, Dilan Ece Geylan, Ali Yusuf Öner
PURPOSE: To report the clinical and radiological results of patients with talar osteochondral lesions who were treated by microfracture and cell-free scaffold implantation in a single-step arthroscopic surgery. METHODS: Forty patients, treated with a single-step arthroscopic surgery, were evaluated in this single-center-based retrospective study. Patients with degenerative arthritis (n = 1), history of ankle fracture (n = 1), kissing lesions (n = 1), lower extremity deformity (n = 1), and lesions <1...
September 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28860398/revision-anatomical-reconstruction-of-the-lateral-ligaments-of-the-ankle-augmented-with-suture-tape-for-patients-with-a-failed-brostr%C3%A3-m-procedure
#9
B K Cho, Y M Kim, S M Choi, H W Park, N F SooHoo
AIMS: The aim of this prospective study was to evaluate the intermediate-term outcomes after revision anatomical ankle ligament reconstruction augmented with suture tape for a failed modified Broström procedure. PATIENTS AND METHODS: A total of 30 patients with persistent instability of the ankle after a Broström procedure underwent revision augmented with suture tape. Of these, 24 patients who were followed up for more than two years were included in the study...
September 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28844303/calcaneal-ewing-s-sarcoma-with-skip-metastases-to-tarsals-and-lymph-node-involvement-a-case-report
#10
Koray Şahin, Serkan Bayram, Ahmet Salduz
Ewing's sarcoma (ES) represents the second most common primary malignant tumor of bone of children and occurs rarely in the bones of the foot. Dissemination to regional lymph nodes and skip metastases to adjacent bones are thought to be uncommon. We report a case of a 19-year-old female with the diagnosis of ES of the right calcaneus. Six months earlier, she had presented to the hospital with a history of ankle sprain and was treated with analgesics and ice application. Despite the treatment, the pain over the ankle persisted, her foot swelled progressively, and a mass evolved on the lateral side of the foot...
August 22, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28843551/calcaneocuboid-distraction-arthrodesis-with-synthetic-bone-grafts-preliminary-results-of-an-innovative-bone-grafting-procedure-in-13%C3%A2-patients
#11
Hayato Kobayashi, Yasunori Kageyama, Yoji Shido
Calcaneocuboid distraction arthrodesis (CCDA) is regarded as an effective method for reconstructing adult-acquired flatfoot deformity. In the present study, we present our experience with newly developed rigid β-tricalcium phosphate wedges to treat CCDA to better understand the outcomes of this synthetic bone grafting procedure. A total of 13 feet in 13 patients underwent CCDA with synthetic bone grafts. One male (7.69%) and 12 females (92.31%), with a mean age of 65.07 ± 11.83 (range 36 to 77) years, were followed up for a mean duration of 32...
August 23, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28843549/defining-talar-head-and-neck-pathology-the-malvern-classification-system
#12
REVIEW
Christopher Robin Hood, Jason Roy Miller, Josuha Kevin Hollinger
Talar fractures account for <1% of all fractures in the body and 3% to 6% of pedal fractures. Of these fractures, avulsion and neck fractures represent the most and second most common type, respectively. Several classification systems exist for talar fractures of the talar dome (Berndt-Hardy), talar neck dislocation (Hawkins), and talar body (Sneppen) anatomic locations. Although diverse, they are not all encompassing for fracture patterns of the talus. Another set of pathologic issues occur about the talar head and neck region that can be seen in the clinical setting...
August 23, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28828181/peri-talar-re-alignment-osteotomy-for-joint-preservation-in-asymmetrical-ankle-osteoarthritis
#13
REVIEW
Young Yi, Woochun Lee
Various types of re-alignment surgery are used to preserve the ankle joint in cases of intermediate ankle arthritis with partial joint space narrowing.The short-term and mid-term results after re-alignment surgery are promising, with substantial post-operative pain relief and functional improvement that is reflected by high rates of patient satisfaction.In this context, re-alignment surgery can preserve the joint and reduce the pathological load that acts on the affected area.Good clinical and radiological outcomes can be achieved in asymmetrical ankle osteoarthritis by understanding the specific deformities and appropriate indications for different surgical techniques...
July 2017: EFORT open reviews
https://www.readbyqxmd.com/read/28826786/surgical-treatment-of-chronic-lateral-ankle-instability-using-an-inferior-extensor-retinaculum-flap-a-retrospective-study
#14
Faycal Trichine, Toufik Friha, Azzedine Boukabou, Lamine Belaid, Terek Bouzidi, Mahdjoub Bouzitouna
Chronic lateral ankle instability causes significant problems with physical activity. The purpose of the present study was to evaluate the results of ligamentous retensioning combined with reinforcement using an extensor retinaculum flap. A consecutive series of 38 patients were included with a minimum follow-up duration of 2 years. The functional results were assessed using the Karlsson and American Orthopaedic Foot and Ankle Society scale scores. The pre- and postoperative radiologic assessment was performed using stress radiographs to measure varus tilt and anterior drawer tests...
August 17, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28809629/-talar-neck-fractures-treated-using-percutaneous-screw-fixation
#15
R Veselý, M Kelbl, J Kacián, V Hulka, J Kočiš, R Kunovský
PURPOSE OF THE STUDY Closed reduction and percutaneous fixation of nondisplaced talar neck fractures have been applied by some authors. The aim of this paper is to assess the results and complications of this minimally invasive technique. MATERIAL AND METHODS In the period from 2009 to 2014, twenty-one patients with a talar neck fracture were observed after closed reduction and percutaneous screw fixation in the Traumatological Hospital in Brno. The mean age of the patients was 38 years (range 18-56 years)...
2017: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/28807507/optimizing-arthroscopy-for-osteochondral-lesions-of-the-talus-the-effect-of-ankle-positions-and-distraction-during-anterior-and-posterior-arthroscopy-in-a-cadaveric-model
#16
Phinit Phisitkul, Craig C Akoh, Chamnanni Rungprai, Alexej Barg, Annuziato Amendola, Kevin Dibbern, Donald Anderson
PURPOSE: To quantify arthroscopic accessibility of the talar dome with predefined ankle positions through anterior and posterior approaches. METHODS: Fourteen below-knee cadaver specimens underwent preoperative range of motion assessments. A 30° 2.7-mm arthroscopic camera was used to mark accessible areas at varying ankle positions. Accessible regions were quantified using a surface laser scanner and digital 3 × 3 grid. Statistical analyses were performed to detect differences in arthroscopic accessibility between different flexion angles and noninvasive distraction...
August 11, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28800714/sagittal-subtalar-and-talocrural-joint-assessment-during-ambulation-with-controlled-ankle-movement-cam-boots
#17
Benjamin D McHenry, Emily L Exten, Janelle A Cross, Karen M Kruger, Brian Law, Jessica M Fritz, Gerald Harris
BACKGROUND: The purpose of the current study was to determine sagittal plane talocrural and subtalar kinematic differences between barefoot and controlled ankle movement (CAM) boot walking. This study used fluoroscopic images to determine talar motion relative to tibia and calcaneal motion relative to talus. METHODS: Fourteen male subjects (mean age 24.1 ± 3.5 years) screened for normal gait were tested. A fluoroscopy unit was used to collect images at 200 Hz during stance...
August 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28765340/lack-of-association-for-reported-endocrine-pancreatic-cancer-risk-loci-in-the-pandora-consortium
#18
Daniele Campa, Ofure Obazee, Manuela Pastore, Francesco Panzuto, Valbona Liço, William Greenhalf, Verena Katzke, Francesca Tavano, Eithne Costello, Vincenzo Corbo, Renata Talar-Wojnarowska, Oliver Strobel, Carlo Federico Zambon, John P Neoptolemos, Giulia Zerboni, Rudolf Kaaks, Timothy J Key, Carlo Lombardo, Krzysztof Jamroziak, Domenica Gioffreda, Thilo Hackert, Kay-Tee Khaw, Stefano Landi, Anna Caterina Milanetto, Luca Landoni, Rita T Lawlor, Franco Bambi, Felice Pirozzi, Daniela Basso, Claudio Pasquali, Gabriele Capurso, Federico Canzian
Background: Pancreatic neuroendocrine tumors (PNETs) are rare neoplasms for which very little is known about either environmental or genetic risk factors. Only a handful of association studies have been performed so far, suggesting a small number of risk loci.Methods: To replicate the best findings, we have selected 16 SNPs suggested in previous studies to be relevant in PNET etiogenesis. We genotyped the selected SNPs (rs16944, rs1052536, rs1059293, rs1136410, rs1143634, rs2069762, rs2236302, rs2387632, rs3212961, rs3734299, rs3803258, rs4962081, rs7234941, rs7243091, rs12957119, and rs1800629) in 344 PNET sporadic cases and 2,721 controls in the context of the PANcreatic Disease ReseArch (PANDoRA) consortium...
August 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28758444/response-to-letter-regarding-anterior-heterotopic-ossification-at-the-talar-neck-after-total-ankle-arthroplasty
#19
LETTER
Sang-Hun Lee
No abstract text is available yet for this article.
August 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28758443/letter-regarding-anterior-heterotopic-ossification-at-the-talar-neck-after-total-ankle-arthroplasty
#20
LETTER
Jorge Javier Del Vecchio, Anuar Emanuel Uzair, Mauricio Esteban Ghioldi
No abstract text is available yet for this article.
August 2017: Foot & Ankle International
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