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https://www.readbyqxmd.com/read/29325482/reply-to-letter-to-editor-regarding-correlation-between-uterine-artery-doppler-indices-and-menstrual-irregularities-among-levonorgestrel-releasing-intrauterine-system-and-depot-medroxyprogesterone-acetate-users-a-prospective-observational-study
#1
Mohamed Rezk, Alaa Al-Halaby, Mohamed Emarh, Mohamed Shawky
No abstract text is available yet for this article.
January 12, 2018: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/29323559/reply-to-letter-to-editor-regarding-risk-of-bacterial-vaginosis-trichomonas-vaginalis-and-candida-albicans-infection-among-new-users-of-combined-hormonal-contraception-compared-to-levonorgestrel-releasing-intrauterine-system
#2
Mohamed Rezk, Tarek Sayyed, Alaa Masood, Ragab Dawood
No abstract text is available yet for this article.
January 11, 2018: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/29322856/perforation-risk-and-intra-uterine-devices-results-of-the-euras-iud-5-year-extension-study
#3
Clare Barnett, Sabine Moehner, Thai Do Minh, Klaas Heinemann
OBJECTIVES: The objective of this analysis was to identify intra-uterine devices (IUD) perforations detected from 12 to 60 months following IUD insertion, and to combine this information with (our previously published) data about perforations detected in the first 12 months to calculate cumulative perforation rates. METHODS AND MATERIALS: Prospective, non-interventional cohort study with new users of levonorgestrel-releasing intra-uterine systems (LNG-IUS) and copper-IUD...
January 11, 2018: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/29316527/contrasting-effects-of-individual-versus-combined-estrogen-and-progestogen-regimens-as-working-memory-load-increases-in-middle-aged-ovariectomized-rats-one-plus-one-does-not-equal-two
#4
Alesia V Prakapenka, Ryoko Hiroi, Alicia M Quihuis, Catie Carson, Shruti Patel, Claire Berns-Leone, Carly Fox, Rachael W Sirianni, Heather A Bimonte-Nelson
Most estrogen-based hormone therapies are administered in combination with a progestogen, such as Levonorgestrel (Levo). Individually, the estrogen 17β-estradiol (E2) and Levo can improve cognition in preclinical models. However, although these hormones are often given together clinically, the impact of the E2 + Levo combination on cognitive function has yet to be methodically examined. Thus, we investigated E2 + Levo treatment on a cognitive battery in middle-aged, ovariectomized rats. When administered alone, E2 and Levo treatments each enhanced spatial working memory relative to vehicle treatment, whereas the E2 + Levo combination impaired high working memory load performance relative to E2 only and Levo only treatments...
December 7, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29309550/hormonal-contraception-and-hiv-1-acquisition-biological-mechanisms
#5
Janet P Hapgood, Charu Kaushic, Zdenek Hel
Access to effective affordable contraception for women is critical for individual and public health. A wide range of hormonal contraceptives (HCs) which differ in the composition, concentration of progestin component, frequency of dosage and method of administration, is currently available globally. However, the options are rather limited in settings with restricted economic resources that frequently overlap with areas of high HIV-1 prevalence. The predominant contraceptive used in Sub-Saharan Africa is the progestin-only three-monthly injectable depo-medroxyprogesterone acetate (DMPA)...
January 4, 2018: Endocrine Reviews
https://www.readbyqxmd.com/read/29298525/bleeding-pattern-difference-between-levonorgestrel-intrauterine-system-and-copper-intrauterine-devices-inserted-immediately-post-abortion-a-multicenter-prospective-observational-cohort-study-in-chinese-women
#6
Xiaoning Chen, Qianxi Li, Xiaoye Wang, Jing Chen, Wen Lv, Bin Shi, Hong Wang, Jianru Luo, Jian Li
BACKGROUND: To describe the bleeding pattern (primary outcome), side effects, treatment satisfaction, and 6-month continuity rates of 52 mg levonorgestrel-intrauterine system (LNG-IUS) and copper intrauterine device (Cu-IUD) inserted immediately after abortion. METHODS: This multicenter, prospective, observational cohort study enrolled healthy women (aged ≥18 years) inserted with LNG-IUS or Cu-IUD immediately after first-trimester surgical abortion and were followed up to 6 months...
January 3, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29288103/incidence-of-androgenic-dermatological-side-effects-following-placement-of-a-levonorgestrel-intrauterine-device-for-menorrhagia-a-survey-based-study
#7
Jenna Janiga Lullo, Elizabeth Ethington, Ashish Arshanapalli, Jeave Reserva, Angela Jiang, William Adams, Scott Graziano, Rebecca Tung
No abstract text is available yet for this article.
December 26, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29278560/are-hormonal-contraceptives-less-effective-in-overweight-and-obese-women
#8
Shriya Patel, Lawrence Carey
Loss of efficacy of hormonal contraceptives is of particular concern for women who are overweight or obese. Only recently have clinical trials started to include overweight and obese women in their study populations, limiting the data available on which to make the best prescribing decisions for hormonal contraceptives for these patients. Other methods, such as the copper or levonorgestrel-containing intrauterine device, the etonogestrel implant, and depot medroxyprogesterone acetate, are preferred over combined oral contraceptives, the transdermal patch, and the vaginal ring...
January 2018: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/29260904/ulipristal-acetate-for-the-management-of-acute-heavy-menstrual-bleeding-without-fibroids
#9
Josep Estadella, Pia Español, Fiorella Ascencio, Josep Perelló, Joaquim Calaf
Heavy menstrual bleeding is a common condition among women of childbearing age. Although hysterectomy was the usual approach in acute cases in the past, other minimally invasive therapies or pharmacological alternatives, such as the levonorgestrel intrauterine device have shown to be highly effective. This case report presents the case of a pluripathological patient with acute heavy menstrual bleeding and severe anemia, who was successfully managed with ulipristal acetate, a selective progesterone receptor modulator...
December 20, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29246819/discordance-between-self-reported-contraceptive-use-and-detection-of-exogenous-hormones-among-malawian-women-enrolling-in-a-randomized-clinical-trial
#10
Anuli N Nwaohiri, Jennifer H Tang, Frank Stanczyk, Lameck Chinula, Stacey Hurst, Nicole L Davis, Gerald Tegha, Lisa Haddad, Athena P Kourtis
OBJECTIVE: To assess the extent of concordance between self-reported contraceptive use and the presence of contraceptive progestins in serum. STUDY DESIGN: We evaluated self-reported contraceptive use by using radioimmunoassay to examine baseline serum levels of medroxyprogesterone acetate (MPA) and levonorgestrel (LNG) among 97 Malawian women enrolling in a contraceptive trial. RESULTS: Twelve percent (12/97) of study participants who reported no hormonal contraceptive use in the previous 6months had either MPA or LNG detected in their serum...
December 13, 2017: Contraception
https://www.readbyqxmd.com/read/29223999/two-years-follow-up-of-patients-with-abnormal-uterine-bleeding-after-insertion-of-the-levonorgestrel-releasing-intrauterine-system
#11
Numan Cim, Sunullah Soysal, Sena Sayan, Begum Yildizhan, Erbil Karaman, Orkun Cetin, Harun Egemen Tolunay, Recep Yildizhan
AIM: To evaluate the efficacy and safety of levonorgestrel-releasing intrauterine system (LNG-IUS) in the long-term treatment of heavy menstrual blood loss in women unrelated to intrauterine pathology. METHODS: One hundred and six parous women aged 33-48 years with recurrent heavy menstrual bleeding (HMB) participated in this study. The women were followed up for 24 months and were assessed for intensity of bleeding both for pre- and post-insertion periods. An LNG-IUS was inserted in each patient within 7 days of the start of menstrual flow...
December 8, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29215767/exposure-to-levonorgestrel-increases-nest-acquisition-success-and-decreases-sperm-motility-in-the-male-fathead-minnow-pimephales-promelas
#12
Tyler Frankel, Lance Yonkos, Franklin Ampy, Jack Frankel
Progestins are utilized as a component of human contraceptives, and enter the environment via wastewater treatment plant effluent. Certain progestins activate fish androgen receptors and cause decreases in fecundity and masculinization of females. In this study, a nest acquisition assay and computer assisted sperm analysis (CASA) was used to examine the effects of levonorgestrel (LNG) on male fathead minnow (Pimephales promelas) reproductive fitness. Males were exposed to 0, 10, or 100ng/L LNG for 14d. Combinations of a control male and a male from one of the treatments were placed into a competitive nesting assay, and time each male spent holding the nest and time spent exhibiting aggressive behaviors were analyzed at 48hrs post-exposure...
December 7, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29215513/treatment-of-low-risk-endometrial-cancer-and-complex-atypical-hyperplasia-with-the-levonorgestrel-releasing-intrauterine-device
#13
Navdeep Pal, Russell R Broaddus, Diana L Urbauer, Nyla Balakrishnan, Andrea Milbourne, Kathleen M Schmeler, Larissa A Meyer, Pamela T Soliman, Karen H Lu, Pedro T Ramirez, Lois Ramondetta, Diane C Bodurka, Shannon N Westin
OBJECTIVE: To assess efficacy of the levonorgestrel-releasing intrauterine device (LNG-IUD) for treatment of complex atypical hyperplasia or low-grade endometrial cancer. METHODS: This retrospective case series included all patients treated with the LNG-IUD for complex atypical hyperplasia or early-grade endometrial cancer from January 2003 to June 2013. Response rates were calculated and the association of response with clinicopathologic factors, including age, body mass index, and uterine size, was determined...
January 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29198449/effects-of-flibanserin-on-the-pharmacokinetics-of-a-combined-ethinylestradiol-levonorgestrel-oral-contraceptive-in-healthy-premenopausal-women-a-randomized-crossover-study
#14
Crista Johnson-Agbakwu, Louise Brown, James Yuan, Robert Kissling, David J Greenblatt
PURPOSE: This study aimed to investigate the effect of steady-state exposure to flibanserin, a 5-HT1A agonist/5-HT2A antagonist approved for the treatment of hypoactive sexual desire disorder in premenopausal women, on the single-dose pharmacokinetics of the contraceptive steroids ethinylestradiol and levonorgestrel in healthy premenopausal women. METHODS: Healthy female volunteers (N = 24) received 2 single doses of a combined oral contraceptive containing ethinylestradiol 30 μg and levonorgestrel 150 μg, either alone (reference) or preceded by treatment with flibanserin 100 mg once daily for 14 days (test)...
November 30, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/29192420/use-of-a-levonorgestrel-releasing-intrauterine-device-for-menorrhagia-treatment-during-adjuvant-therapy-of-adrenocortical-carcinoma-with-mitotane
#15
Piotr Robert Szkodziak, Piotr Czuczwar, Sławomir Woźniak, Filip Szkodziak, Tomasz Paszkowski
Adrenocortical carcinoma is a rare tumour with high malignancy and poor prognosis. This tumour is rarely diagnosed in the reproductive age. Complete surgical resection is the only curative treatment for adrenal cancer in all stages. After surgery adjuvant chemotherapy is required. Mitotane is the most important drug in adrenal cancer chemotherapy. Mitotane's mode of action is not entirely explained. Animal studies have shown that the substance exerts a direct cytotoxic effect on the cells of the adrenal cortex...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/29185840/single-dose-levonorgestrel-emergency-contraception-and-silent-barriers-to-its-access-is-it-really-just-one-step
#16
Amanda H Ritter, Christine R Isaacs, Stephanie M Lee, Alan J Lee
BACKGROUND: Single-dose levonorgestrel has been legally available over the counter in the United States without age restriction since 2013. The objective of this study was to discover if there are barriers to access and to determine if such barriers vary based on the gender of the person making the purchase. MATERIALS AND METHODS: A male and female caller contacted 146 Richmond, Virginia pharmacies listed on the Plan B One Step® website. Ultimately, these callers interviewed 90 pharmacies via phone and used a rehearsed standardized script to ask eight questions regarding emergency contraception (EC) in relation to availability, age restrictions, parental consent, counseling requirements, and a male's ability to purchase the product...
November 29, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/29175414/the-effect-of-drug-content-reduction-on-the-in-vitro-and-in-vivo-properties-of-levonorgestrel-releasing-intravaginal-rings
#17
Rüdiger Nave, Tero Jalkanen, Christine Talling, Masato Kaneko, Shunji Matsuki, Joachim Höchel
Intravaginal rings (IVR) are an option for continuous administration of drugs in women. However, a considerable amount of excess drug often remains in the ring upon removal. The current study focuses on comparing two IVRs releasing levonorgestrel (LNG). Both formulations were designed to release 40 μg of LNG daily, however with a significant difference in the total amount of drug (10.6 mg vs 176.9 mg). Numerical simulations and in vitro release rate testing were utilized in designing the IVRs and confirming the similarity of drug release...
November 23, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29166843/stagnant-contraceptive-sales-after-the-zika-epidemic-in-brazil
#18
Luis Bahamondes, Moazzam Ali, Ilza Monteiro, Arlete Fernandes
OBJECTIVES: Our aim was to assess national hormonal and non-hormonal contraceptive sales in Brazil after the Zika virus outbreak. METHODS: Pharmaceutical companies based in Brazil provided data on monthly sales from September 2016 to June 2017. Data from both the public and private sectors were obtained about sales of registered, available modern contraceptive methods: combined oral contraceptive pill; progestin-only pill; vaginal and transdermal contraceptives; injectable contraceptives; long-acting reversible contraceptive (LARC) methods, including the copper-releasing intrauterine device, the levonorgestrel-releasing intrauterine system and the etonogestrel-releasing subdermal implant; and emergency contraceptive pills...
November 23, 2017: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/29138033/randomized-trial-of-high-and-low-fidelity-simulation-to-teach-intrauterine-contraception-placement
#19
Siripanth Nippita, Miriam J Haviland, Sara F Voit, Judith Perez-Peralta, Michele R Hacker, Maureen E Paul
BACKGROUND: High fidelity simulation creates conditions that resemble real circumstances, and can help teach procedures such as intrauterine contraception placement. Its impact on skill retention has not been studied. OBJECTIVE: To evaluate novice learners' skills, attitudes, and knowledge on placement of intrauterine contraception when trained using a high-fidelity commercially available simulator compared with a low-fidelity simulator. STUDY DESIGN: We recruited senior nurse practitioner students and interns in obstetrics and gynecology and family medicine inexperienced with intrauterine contraception placement...
November 11, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29133336/psychological-behavioural-and-physiological-effects-of-three-long-acting-reversible-contraception-larc-methods-protocol-for-an-ancillary-study-of-the-echo-randomised-trial
#20
Mandisa Singata-Madliki, G Justus Hofmeyr, Florence Carayon-Lefebvre d'Hellencourt, Theresa Anne Lawrie
INTRODUCTION: This is the protocol for an ancillary study to the multicentre Evidence for Contraceptive Options and HIV Outcomes (ECHO) Trial, a three-arm randomised trial comparing the effects of depot medroxyprogesterone acetate (DMPA), the levonorgestrel (LNG) implant and the copper intrauterine device (IUD) on HIV incidence (NCT02550067 pre-results). The ancillary study will compare other non-contraceptive effects of these three long-acting, reversible contraceptions about which there is little existing comparative evidence...
November 12, 2017: BMJ Open
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