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https://www.readbyqxmd.com/read/28641051/beneficial-role-of-citrus-fruit-polyphenols-against-hepatic-dysfunctions-a-review
#1
Md Mohabbulla Mohib, Kazi Afnan, Tasfiq Zaman Paran, Salma Khan, Juthika Sarker, Nahid Hasan, Istiaque Hasan, Md Abu Taher Sagor
Alcoholic liver diseases and virus-induced hepatic dysfunctions are prevalent in western countries. Evidence also suggests that hyperglycemia and insulin resistance are key players in the development of hepatic diseases and their complications. Since the comorbid diseases like obesity, diabetes and vascular dysfunctions primarily affect liver, the modern therapies against other hepatic dysfunctions are becoming a major challenge to treat. In addition to these, polypharmacy and adverse drug reactions (ADRs) are further aggravating the phenomenon...
June 22, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28616020/minocycline-targets-multiple-secondary-injury-mechanisms-in-traumatic-spinal-cord-injury
#2
REVIEW
Robert B Shultz, Yinghui Zhong
Minocycline hydrochloride (MH), a semi-synthetic tetracycline derivative, is a clinically available antibiotic and anti-inflammatory drug that also exhibits potent neuroprotective activities. It has been shown to target multiple secondary injury mechanisms in spinal cord injury, via its anti-inflammatory, anti-oxidant, and anti-apoptotic properties. The secondary injury mechanisms that MH can potentially target include inflammation, free radicals and oxidative stress, glutamate excitotoxicity, calcium influx, mitochondrial dysfunction, ischemia, hemorrhage, and edema...
May 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28500967/a-systematic-review-on-potential-mechanisms-of-minocycline-in-kidney-diseases
#3
REVIEW
Hamed Haghi-Aminjan, Mohammad Hossein Asghari, Mohammad Hadi Goharbari, Mohammad Abdollahi
Kidney diseases need specialized health care and still are a reason of death. There is a large body of evidence that indicates minocycline possesses some cytoprotective effects beside of antibacterial properties. In this review, we aimed to explain cytoprotective mechanisms and kidney protection of minocycline. In order to find the effects of minocycline on kidney diseases a systematic literature search was performed, according to the guidelines proposed at the PRISMA statement in the electronic databases, including: PubMed, Scopus, and Web of Science up to August 2016, using the term 'minocycline' combined either by 'kidney' or 'renal' and published in English language...
February 8, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28322956/polysaccharide-of-black-cumin-nigella-sativa-modulates-molecular-signaling-cascade-of-gastric-ulcer-pathogenesis
#4
Srikanta Belagihalli Manjegowda, Harsha Mysore Rajagopal, Shylaja Mallaiah Dharmesh
Gastric ulcer is a multi-step disease and healing requires a complex process including repair and re-architecture of gastric mucosa with the involvement of molecular events. Current study was designed to understand the gastric ulcer healing mechanism of rhamnogalacturonan-I type pectic polysaccharide of black cumin (BCPP) utilizing acetic acid induced gastric ulcers in rats. BCPP fed groups at 200mg/kg b.w. for 10days showed up to 85% healing of gastric ulcers with modulation of key molecular events involved in ulcer healing process such as increase in gastric mucin content, cyclooxygenase-2 (Cox-2) and prostaglandin E2 (PGE2)...
August 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28265034/extracellular-matrix-inflammation-in-vascular-cognitive-impairment-and-dementia
#5
REVIEW
Gary A Rosenberg
Vascular cognitive impairment and dementia (VCID) include a wide spectrum of chronic manifestations of vascular disease related to large vessel strokes and small vessel disease (SVD). Lacunar strokes and white matter (WM) injury are consequences of SVD. The main vascular risk factor for SVD is brain hypoperfusion from cerebral blood vessel narrowing due to chronic hypertension. The hypoperfusion leads to activation and degeneration of astrocytes with the resulting fibrosis of the extracellular matrix (ECM)...
March 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28106777/neuroprotection-by-caffeine-in-hyperoxia-induced-neonatal-brain-injury
#6
Stefanie Endesfelder, Ulrike Weichelt, Evelyn Strauß, Anja Schlör, Marco Sifringer, Till Scheuer, Christoph Bührer, Thomas Schmitz
Sequelae of prematurity triggered by oxidative stress and free radical-mediated tissue damage have coined the term "oxygen radical disease of prematurity". Caffeine, a potent free radical scavenger and adenosine receptor antagonist, reduces rates of brain damage in preterm infants. In the present study, we investigated the effects of caffeine on oxidative stress markers, anti-oxidative response, inflammation, redox-sensitive transcription factors, apoptosis, and extracellular matrix following the induction of hyperoxia in neonatal rats...
January 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28106292/23-hydroxytormentic-acid-protects-human-dermal-fibroblasts-by-attenuating-uva-induced-oxidative-stress
#7
Hae Jeong Youn, Ki Bbeum Kim, Hyo-Sun Han, In-Sook An, Kyu Joong Ahn
BACKGROUND: Ultraviolet A (UVA), one of the major components of sunlight, can penetrate the dermal layer of the skin and generate reactive oxygen species (ROS). It causes alterations in the dermal connective tissue and gene expression, inflammation, photoaging, and DNA damage. AIMS: Therefore, the harmful effects of UVA and strategies to reduce it have been consistently investigated. 23-Hydroxytormentic acid (23-HTA) has been demonstrated to improve drug-induced nephrotoxicity and exhibit several free radical scavenging effects with other molecules...
March 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/27980241/therapeutic-strategies-to-attenuate-hemorrhagic-transformation-after-tissue-plasminogen-activator-treatment-for-acute-ischemic-stroke
#8
Masato Kanazawa, Tetsuya Takahashi, Masatoyo Nishizawa, Takayoshi Shimohata
This review focuses on the mechanisms and emerging concepts of stroke and therapeutic strategies for attenuating hemorrhagic transformation (HT) after tissue plasminogen activator (tPA) treatment for acute ischemic stroke (AIS). The therapeutic time window for tPA treatment has been extended. However, the patients who are eligible for tPA treatment are still <5% of all patients with AIS. The risk of serious or fatal symptomatic hemorrhage increases with delayed initiation of treatment. HT is thought to be caused by 1) ischemia/reperfusion injury; 2) the toxicity of tPA itself; 3) inflammation; and/or 4) remodeling factor-mediated effects...
March 1, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/27790149/co-micronized-palmitoylethanolamide-polydatin-treatment-causes-endometriotic-lesion-regression-in-a-rodent-model-of-surgically-induced-endometriosis
#9
Rosanna Di Paola, Roberta Fusco, Enrico Gugliandolo, Rosalia Crupi, Maurizio Evangelista, Roberta Granese, Salvatore Cuzzocrea
Endometriosis is a chronic, painful disease characterized by the presence of endometrial glands and stroma outside the uterine cavity. Palmitoylethanolamide (PEA), an endogenous fatty acid amide, has anti-inflammatory and neuroprotective effects. PEA lacks free radical scavenging activity, unlike polydatin (PLD), a natural precursor of resveratrol. The aim of this study was to investigate the effect of orally administered co-micronized PEA/polydatin [m(PEA/PLD)] in an autologous rat model of surgically induced endometriosis...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27733866/inhibitory-effect-of-trans-ferulic-acid-on-proliferation-and-migration-of-human-lung-cancer-cells-accompanied-with-increased-endogenous-reactive-oxygen-species-and-%C3%AE-catenin-instability
#10
Yao Fong, Chia-Chun Tang, Huei-Ting Hu, Hsin-Yu Fang, Bing-Hung Chen, Chang-Yi Wu, Shyng-Shiou Yuan, Hui-Min David Wang, Yen-Chun Chen, Yen-Ni Teng, Chien-Chih Chiu
BACKGROUND: Trans-ferulic (FA) acid exhibits antioxidant effects in vitro. However, the underlying mechanism of trans-FA activity in cellular physiology, especially cancer physiology, remains largely unknown. This study investigated the cellular physiological effects of trans-FA on the H1299 human lung cancer cell line. METHODS: The 2,2-diphenyl-1-picrylhydrazyl assay was used to determine free radical scavenging capability. Assessment of intracellular reactive oxygen species (ROS) was evaluated using oxidized 2',7'-dichlorofluorescin diacetate and dihydroethidium staining...
2016: Chinese Medicine
https://www.readbyqxmd.com/read/27618095/anticancer-efficacy-of-polyphenols-and-their-combinations
#11
REVIEW
Aleksandra Niedzwiecki, Mohd Waheed Roomi, Tatiana Kalinovsky, Matthias Rath
Polyphenols, found abundantly in plants, display many anticarcinogenic properties including their inhibitory effects on cancer cell proliferation, tumor growth, angiogenesis, metastasis, and inflammation as well as inducing apoptosis. In addition, they can modulate immune system response and protect normal cells against free radicals damage. Most investigations on anticancer mechanisms of polyphenols were conducted with individual compounds. However, several studies, including ours, have indicated that anti-cancer efficacy and scope of action can be further enhanced by combining them synergistically with chemically similar or different compounds...
September 9, 2016: Nutrients
https://www.readbyqxmd.com/read/27614125/traumatic-brain-injury-induced-matrix-metalloproteinase2-cleaves-cxcl12%C3%AE-stromal-cell-derived-factor-1%C3%AE-and-causes-neurodegeneration
#12
P M Abdul-Muneer, Adriano Andrea Conte, Debanjan Haldar, Mathew Long, Rachel K Patel, Vijayalakshmi Santhakumar, Christopher M Overall, Bryan J Pfister
Traumatic brain injury (TBI), even at mild levels, can activate matrix metalloproteinases (MMPs) and the induction of neuroinflammation that can result in blood brain barrier breakdown and neurodegeneration. MMP2 has a significant role in neuroinflammation and neurodegeneration by modulating the chemokine CXCL12α (stromal cell derived factor SDF-1α) signaling pathway and the induction of apoptosis. SDF-1α is responsible for cell proliferation and differentiation throughout the nervous system and is also implicated in various neurodegenerative illnesses...
January 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27589890/a-free-radical-scavenger-edaravone-suppresses-systemic-inflammatory-responses-in-a-rat-transient-focal-ischemia-model
#13
Norio Fujiwara, Angel T Som, Loc-Duyen D Pham, Brian J Lee, Emiri T Mandeville, Eng H Lo, Ken Arai
A free radical scavenger edaravone is clinically used in Japan for acute stroke, and several basic researches have carefully examined the mechanisms of edaravone's protective effects. However, its actions on pro-inflammatory responses under stroke are still understudied. In this study, we subjected adult male Sprague-Dawley rats to 90-min middle cerebral artery (MCA) occlusion followed by reperfusion. Edaravone was treated twice via tail vein; after MCA occlusion and after reperfusion. As expected, edaravone-treated group showed less infarct volume and edema formation compared with control group at 24-h after an ischemic onset...
October 28, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27572503/curcumin-inhibits-h2o2-induced-invasion-and-migration-of-human-pancreatic-cancer-via-suppression-of-the-erk-nf-%C3%AE%C2%BAb-pathway
#14
Lei Cao, Jiangbo Liu, Lun Zhang, Xue Xiao, Wei Li
Curcumin (diferuloylmethane), a natural polyphenol present in turmeric, possesses a wide spectrum of pharmacological properties, including antioxidant and antitumor metastatic activities. However, the underlying mechanisms by which curcumin suppresses the metastasis of pancreatic cancer are still not fully elucidated. Our previous study demonstrated that a moderate amount of hydrogen peroxide (H2O2) is able to promote pancreatic cancer invasion. The aim of this study was to determine whether curcumin can suppress H2O2-induced tumor invasive and migratory abilities...
October 2016: Oncology Reports
https://www.readbyqxmd.com/read/27506904/hdac-1-and-6-modulate-cell-invasion-and-migration-in-clear-cell-renal-cell-carcinoma
#15
Swathi Ramakrishnan, ShengYu Ku, Eric Ciamporcero, Kiersten Marie Miles, Kris Attwood, Sreenivasulu Chintala, Li Shen, Leigh Ellis, Paula Sotomayor, Wendy Swetzig, Ray Huang, Dylan Conroy, Ashley Orillion, Gokul Das, Roberto Pili
BACKGROUND: Class I histone deacetylases (HDACs) have been reported to be overexpressed in clear cell renal cell carcinoma (ccRCC), whereas the expression of class II HDACs is unknown. METHODS: Four isogenic cell lines C2/C2VHL and 786-O/786-OVHL with differential VHL expression are used in our studies. Cobalt chloride is used to mimic hypoxia in vitro. HIF-2α knockdowns in C2 and 786-O cells is used to evaluate the effect on HDAC 1 expression and activity. Invasion and migration assays are used to investigate the role of HDAC 1 and HDAC 6 expression in ccRCC cells...
August 9, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27365982/evaluation-of-skin-anti-aging-potential-of-citrus-reticulata-blanco-peel
#16
Vinita D Apraj, Nancy S Pandita
BACKGROUND: The peel of Citrus reticulata Blanco is traditionally used as tonic, stomachic, astringent, and carminative. It is also useful in skin care. OBJECTIVE: To study the anti-aging potential of alcoholic extracts of C. reticulata Blanco peel using in vitro antioxidant and anti-enzyme assays. MATERIALS AND METHODS: Plant extracts were obtained by Soxhlation (CR HAE- Hot Alcoholic Extract of Citrus reticulata) and maceration method (CR CAE- Cold Alcoholic Extract of Citrus reticulata)...
July 2016: Pharmacognosy Research
https://www.readbyqxmd.com/read/27314393/terminalia-bellirica-extract-inhibits-low-density-lipoprotein-oxidation-and-macrophage-inflammatory-response-in-vitro
#17
Miori Tanaka, Yoshimi Kishimoto, Emi Saita, Norie Suzuki-Sugihara, Tomoyasu Kamiya, Chie Taguchi, Kaoruko Iida, Kazuo Kondo
The deciduous tree Terminalia bellirica found in Southeast Asia is extensively used in traditional Indian Ayurvedic medicine for the treatment of hypertension, rheumatism, and diabetes. The anti-atherogenic effect of Terminalia bellirica fruit has not been fully elucidated. Here, we investigated the effect of Terminalia bellirica extract (TBE) on low-density lipoprotein (LDL) oxidation and inflammation in macrophages. TBE showed 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity (EC50: 7.2 ± 1...
2016: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/27276232/therapeutic-role-of-a-synthesized-calcium-phosphate-nanocomposite-material-on-hepatocarcinogenesis-in-rats
#18
Magdy Mohammed, Eman Abdel-Gawad, Sameh Awwad, Eman Kandil, Basma El-Agamy
Nanotechnology research is booming worldwide, and the general belief is that medical and biological applications will form the greatest sector of expansion over the next decade. With this in mind, this study was designed to evaluate the therapeutic effects of a synthesized tricalcium phosphate nanocomposite material (nano-TCP) on hepatocarcinoma in a rat model, as initiated with diethylnitrosamine (DEN) and promoted with phenobarbital (PB). Hepatocarcinoma was induced with intraperitoneal injections of DEN (50 mg·(kg body mass)(-1)) 3 times a week for 2 weeks...
June 2016: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/27271552/update-on-the-role-of-molecular-factors-and-fibroblasts-in-the-pathogenesis-of-dupuytren-s-disease
#19
Massimiliano Tripoli, Adriana Cordova, Francesco Moschella
The mechanism by which the fibroblast is able to trigger palmar fibromatosis is still not yet fully understood. It would appear certain that the "abnormal" fibroblasts continuously synthesise profibrotic cytokines which are able to determine the activation to myofibroblasts, to stimulate them to the further proliferation and synthesis of other cytokines, to modify the cells' differentiation and ultrastructural characteristics, as well as the production of matrix and other proteins. Several fibroblast growth factors have been suggested to be responsible of an abnormal cell activation with an aberrantly elevated collagen synthesis and extracellular deposition in Dupuytren's disease, as TGF-Beta, TNF-Alfa, PDGF, GM-CSF, free radicals, metalloproteinases, sex hormones, gene modified expression, mechanical stimulation...
December 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27240190/7-hydroxycoumarin-prevents-uvb-induced-activation-of-nf-%C3%AE%C2%BAb-and-subsequent-overexpression-of-matrix-metalloproteinases-and-inflammatory-markers-in-human-dermal-fibroblast-cells
#20
Ramasamy Karthikeyan, Govindasamy Kanimozhi, Nagarajan Rajendra Prasad, Balupillai Agilan, Muthusamy Ganesan, Shanmugham Mohana, Gunaseelan Srithar
Ultraviolet B (UVB) irradiation alters multiple molecular pathways in the skin, thereby inducing skin damage. Human dermal fibroblasts (HDFa) were subjected to single UVB-irradiation (18mJ/cm(2)) resulting in reactive oxygen species (ROS) generation, oxidative DNA damage and upregulation of nuclear factor kappa B (NF-κB) expression. Further, it has been observed that there was a significant cytokine production (TNF-α and IL-6) in UVB irradiated HDFa cells. Our results show that 7-hydroxycoumarin (7-OHC) prevents UVB-induced activation of NF-κB thereby subsequently preventing the overexpression of TNF-α and IL-6 in HDFa cells...
August 2016: Journal of Photochemistry and Photobiology. B, Biology
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