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Oxidant stress, stroke

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https://www.readbyqxmd.com/read/29155711/monitoring-astrocyte-reactivity-and-proliferation-in-vitro-under-ischemic-like-conditions
#1
Yancy Ferrer-Acosta, Maxine N Gonzalez-Vega, David E Rivera-Aponte, Solianne M Martinez-Jimenez, Antonio H Martins
Ischemic stroke is a complex brain injury caused by a thrombus or embolus obstructing blood flow to parts of the brain. This leads to deprivation of oxygen and glucose, which causes energy failure and neuronal death. After an ischemic stroke insult, astrocytes become reactive and proliferate around the injury site as it develops. Under this scenario, it is difficult to study the specific contribution of astrocytes to the brain region exposed to ischemia. Therefore, this article introduces a methodology to study primary astrocyte reactivity and proliferation under an in vitro model of an ischemia-like environment, called oxygen glucose deprivation (OGD)...
October 21, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29153608/cofilin-signaling-in-hemin-induced-microglial-activation-and-inflammation
#2
Muhammad Shahdaat Bin Sayeed, Qasim Alhadidi, Zahoor A Shah
Intracerebral hemorrhage (ICH) is the most severe form of stroke and is further exacerbated by the secondary injury involving inflammatory response due to the activation of microglia. This secondary injury is partly due to the toxic effects of hemin, an endogenous breakdown product of hemoglobin. Cofilin, an actin depolymerizing factor, controls actin dynamics and has been previously shown to be involved in mediating neuronal cell death in ischemic conditions and during bacterial lipopolysaccharide induced microglial activation...
December 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29151031/significant-association-between-low-mitochondrial-dna-content-in-peripheral-blood-leukocytes-and-ischemic-stroke
#3
Li-Ming Lien, Hung-Yi Chiou, Hsu-Ling Yeh, Shang-Yen Chiu, Jiann-Shing Jeng, Huey-Juan Lin, Chaur-Jong Hu, Fang-I Hsieh, Yau-Huei Wei
BACKGROUND: Cumulative evidence has shown that low mitochondrial DNA (mtDNA) content is related to elevated oxidative stress and atherosclerosis, which play important roles in ischemic stroke. The objective of this study was to explore the association between mtDNA content in peripheral blood leukocytes and ischemic stroke. METHODS AND RESULTS: A total of 350 patients with first-ever ischemic stroke and 350 healthy controls were recruited in this case-control study...
November 18, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29130998/inhibition-of-the-socs1-jak2-stat3-signaling-pathway-confers-neuroprotection-in-rats-with-ischemic-stroke
#4
Xiao-Lei Wang, Chun-Mei Qiao, Jiong-Ou Liu, Chun-Yang Li
BACKGROUND: The present study aims to investigate the protective effects of the SOCS1-JAK2-STAT3 signaling pathway on neurons in a rat model of ischemic stroke. METHODS: Our study was conducted using an ischemic stroke rat model. After the microglia were extracted, 40 neonatal Sprague-Dawley (SD) rats were assigned into the blank, AG490, model and negative control (NC) groups. The neurological function of all the rats was evaluated. Histopathological changes were observed...
November 6, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29130614/panax-notoginseng-saponins-attenuate-cardiomyocyte-apoptosis-through-mitochondrial-pathway-in-natural-aging-rats
#5
Zhiyong Zhou, Jiao Wang, Yanan Song, Yumin He, Changcheng Zhang, Chaoqi Liu, Haixia Zhao, Yaoyan Dun, Ding Yuan, Ting Wang
Panax notoginseng saponins (PNS) have been widely used in the cardiovascular system for the treatment of cardiovascular diseases and stroke in China. In this study, we investigated the anti-apoptotic effect of PNS on cardiomyocytes in the natural aging rat and explored the potential mechanisms regarding oxidative stress and mitochondrial function signaling pathways. Male Sprague-Dawley rats were randomly divided into five groups: adult control (3-month old), aging control (24-month old), and different doses of PNS-treated aging rat groups (10, 30, 60 mg/kg/day, orally)...
November 12, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29130334/pulsed-epr-imaging-applications-in-the-studies-of-tumor-physiology
#6
Shun Kishimoto, Ken-Ichiro Matsumoto, Keita Saito, Ayano Enomoto, Shingo Matsumoto, James Mitchell, Nallathamby Devasahayam, Murali C Krishna
SIGNIFICANCE: Electron Paramagnetic Resonance imaging (EPRI) is a powerful technique capable of generating images of tissue oxygenation using exogenous paramagnetic probes such as trityl radicals or nitroxyl radicals. Using principles similar to Magnetic Resonance Imaging (MRI) with field gradients, the spatial distribution of the paramagnetic probecan be generatedand,from its spectral features, spatial maps of oxygen can be obtained from live objects. In this review, two methods of signal acquisition, image formation/reconstruction will be described...
November 12, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29128801/oleuropein-protects-intracerebral-hemorrhage-induced-disruption-of-blood-brain-barrier-through-alleviation-of-oxidative-stress
#7
Jing Shi, Guofeng Wu, Xiaohua Zou, Ke Jiang
BACKGROUND: Intracerebral haemorrhage (ICH) as a devastating form of stroke has remained a public health threat due to lack of FDA-approved therapy. Oxidative stress originated from blood cell degradation products plays a crucial role in the ICH pathogenesis. In this study we evaluated oleuropein, a potent natural antioxidant from olive, in a well-established rat ICH model from overall symptoms to detailed molecular mechanism. METHODS: ICH model was established by collagenase injection to the brain of rats, which were randomly divided into groups with vehicle mock treatment, followed by treatment with different doses of oleuropein via daily intraperitoneal injection post-ICH for 3days...
May 11, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29128308/oxidative-stress-and-dna-damage-after-cerebral-ischemia-potential-therapeutic-targets-to-preserve-the-genome-and-improve-stroke-recovery
#8
REVIEW
Peiying Li, R Anne Stetler, Rehana K Leak, Yejie Shi, Yan Li, Weifeng Yu, Michael V L Bennett, Jun Chen
The past two decades have witnessed remarkable advances in oxidative stress research, particularly in the context of ischemic brain injury. Oxidative stress in ischemic tissues compromises the integrity of the genome, resulting in DNA lesions, cell death in neurons, glial cells, and vascular cells, and impairments in neurological recovery after stroke. As DNA is particularly vulnerable to oxidative attack, cells have evolved the ability to induce multiple DNA repair mechanisms, including base excision repair (BER), nucleotide excision repair (NER) and non-homogenous endpoint jointing (NHEJ)...
November 8, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29126723/design-synthesis-and-evaluation-of-ndga-analogues-as-potential-anti-ischemic-stroke-agents
#9
Lili Huang, Jiabing Wang, Liping Chen, Min Zhu, Shoubiao Wu, Shenghui Chu, Yuantie Zheng, Ziliang Fan, Jiafeng Zhang, Wulan Li, Dahui Chen, Xiufei Yang, Sicen Wang, Peihong Qiu, Jianzhang Wu
Exogenous supplementation of antioxidants with ROS scavenging activity would be a potential therapy to cerebral ischemia-reperfusion injury in stroke. In the present study, a series of NDGA analogues with attenuation oxidative stress by directly scavenging ROS and indirectly through keap1/Nrf2/ARE pathway activation were designed and synthesized. All analogues were found to effectively remove ROS directly by DPPH radical scavenging assay, and compound 3a conferred potent protection from the oxidative injury in PC12 cells via promoting Nrf2 to translocate into nucleus and increasing expression of heme oxygenase-1(HO-1), where strongly reduced intracellular ROS level indirectly...
October 16, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29122608/thioredoxin-albumin-fusion-protein-prevents-copper-enhanced-zinc-induced-neurotoxicity-via-its-antioxidative-activity
#10
Ken-Ichiro Tanaka, Mikako Shimoda, Victor T G Chuang, Kento Nishida, Masahiro Kawahara, Tatsuhiro Ishida, Masaki Otagiri, Toru Maruyama, Yu Ishima
Zinc (Zn) is a co-factor for a vast number of enzymes, and functions as a regulator for immune mechanism and protein synthesis. However, excessive Zn release induced in pathological situations such as stroke or transient global ischemia is toxic. Previously, we demonstrated that the interaction of Zn and copper (Cu) is involved in the pathogenesis of Alzheimer's disease and vascular dementia. Furthermore, oxidative stress has been shown to play a significant role in the pathogenesis of various metal ions induced neuronal death...
November 6, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29115993/adjudin-preconditioned-neural-stem-cells-enhance-neuroprotection-after-ischemia-reperfusion-in-mice
#11
Tingting Zhang, Xiao Yang, Tengyuan Liu, Jiaxiang Shao, Ningzhen Fu, Aijuan Yan, Keyi Geng, Weiliang Xia
BACKGROUND: Transplantation of neural stem cells (NSCs) has been proposed as a promising therapeutic strategy for the treatment of ischemia/reperfusion (I/R)-induced brain injury. However, existing evidence has also challenged this therapy on its limitations, such as the difficulty for stem cells to survive after transplantation due to the unfavorable microenvironment in the ischemic brain. Herein, we have investigated whether preconditioning of NSCs with adjudin, a small molecule compound, could enhance their survivability and further improve the therapeutic effect for NSC-based stroke therapy...
November 7, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29114077/the-ubiquitin-e3-ligase-traf6-exacerbates-ischemic-stroke-by-ubiquitinating-and-activating-rac1
#12
Tao Li, Juan-Juan Qin, Xia Yang, Yan-Xiao Ji, Fangliang Guo, Wen-Lin Cheng, Xiaolin Wu, Fu-Han Gong, Ying Hong, Xue-Yong Zhu, Jun Gong, Zhihua Wang, Zan Huang, Zhi-Gang She, Hongliang Li
Stroke is one of the leading causes of morbidity and mortality worldwide. Inflammation, oxidative stress, apoptosis, and excitotoxicity contribute to neuronal death during ischemic stroke; however, the mechanisms underlying these complicated pathophysiological processes remain to be fully elucidated. Here, we found that the expression of tumor necrosis factor receptor-associated factor 6 (TRAF6) was markedly increased after cerebral ischemia/reperfusion (I/R) in mice. TRAF6 ablation in male mice decreased the infarct volume and neurological deficit scores, and decreased pro-inflammatory signaling, oxidative stress and neuronal death after cerebral I/R, whereas transgenic overexpression of TRAF6 in male mice exhibited opposite effects...
November 7, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29103461/neuroprotective-effects-of-yiqihuoxue-calm-wind-capsule-on-ischemic-stroke-in-rats
#13
Jun-Xia Zhang, Jiao-Mei Guo, Hong-Jun Lin, Ting-Ting Zhang, Zhen-Guo Li, Ji-Chun Zhou, Zhen-Zhong Zhang
Stroke remains the third leading cause of death and of adult disability worldwide. Vascular occlusion, followed by ischemic cascade, leads to irreversible tissue injury. Recombinant tissue plasminogen activator is the only FDA approved drug for the current treatment of acute ischemic stroke. However, traditional Chinese medicine has a long history and rich clinical experience in the treatment and rehabilitation of ischemic stroke. Using a classical middle cerebral artery occlusion (MCAO) stroke model, we tested the effectiveness of Yiqihuoxue calm wind (YCW) capsule on neurological function, gross pathology and oxidative stress status in MCAO rats...
October 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29097390/differential-impact-of-serial-measurement-of-nonplatelet-thromboxane-generation-on-long-term-outcome-after-cardiac-surgery
#14
Nikolaos Kakouros, Tyler J Gluckman, John V Conte, Thomas S Kickler, Katherine Laws, Bruce A Barton, Jeffrey J Rade
BACKGROUND: Systemic thromboxane generation, not suppressible by standard aspirin therapy and likely arising from nonplatelet sources, increases the risk of atherothrombosis and death in patients with cardiovascular disease. In the RIGOR (Reduction in Graft Occlusion Rates) study, greater nonplatelet thromboxane generation occurred early compared with late after coronary artery bypass graft surgery, although only the latter correlated with graft failure. We hypothesize that a similar differential association exists between nonplatelet thromboxane generation and long-term clinical outcome...
November 2, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29078967/laser-acupuncture-at-gv20-improves-brain-damage-and-oxidative-stress-in-animal-model-of-focal-ischemic-stroke
#15
Jinatta Jittiwat
The burden of stroke is high and is continually increasing due to a dramatic growth in the world's elderly population. Novel therapeutic strategies are therefore required. The present study sought to determine the effect of laser acupuncture at GV20 on brain damage, oxidative-status markers in the cerebral cortex, and superoxide dismutase in the mitochondria of an animal model of focal ischemic stroke. Wistar rats, weighing 300-350 g, were divided into the following four groups: (1) control; (2) permanent occlusion of the right middle cerebral artery (Rt...
October 2017: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/29073573/exposure-to-traffic-generated-air-pollutants-mediates-alterations-in-brain-microvascular-integrity-in-wildtype-mice-on-a-high-fat-diet
#16
Usa Suwannasual, JoAnn Lucero, Jacob D McDonald, Amie K Lund
Air pollution-exposure is associated with detrimental outcomes in the central nervous system (CNS) such as cerebrovascular disorders, including stroke, and neurodegenerative diseases. While the mechanisms of these CNS-related outcomes involved have not been fully elucidated, exposure to traffic-generated air pollutants has been associated with altered blood brain barrier (BBB) integrity and permeability. The current study investigated whether inhalation exposure to mixed vehicle emissions (MVE) alters cerebral microvascular integrity in healthy 3 mo old C57BL/6 mice, as well as whether exposure-mediated effects were exacerbated by a high-fat (HF) vs...
October 23, 2017: Environmental Research
https://www.readbyqxmd.com/read/29068387/bioactivity-of-olive-oil-phenols-in-neuroprotection
#17
REVIEW
Cristina Angeloni, Marco Malaguti, Maria Cristina Barbalace, Silvana Hrelia
Neurological disorders such as stroke, Alzheimer's and Parkinson's diseases are associated with high morbidity and mortality, and few or no effective options are available for their treatment. These disorders share common pathological characteristics like the induction of oxidative stress, abnormal protein aggregation, perturbed Ca(2+) homeostasis, excitotoxicity, inflammation and apoptosis. A large body of evidence supports the beneficial effects of the Mediterranean diet in preventing neurodegeneration. As the Mediterranean diet is characterized by a high consumption of extra-virgin olive oil it has been hypothesized that olive oil, and in particular its phenols, could be responsible for the beneficial effect of the Mediterranean diet...
October 25, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29065479/psoriasis-and-cardiovascular-comorbidities-focusing-on-severe-vascular-events-cardiovascular-risk-factors-and-implications-for-treatment
#18
REVIEW
Stephen Chu-Sung Hu, Cheng-Che E Lan
Psoriasis is a common and chronic inflammatory disease of the skin. It may impair the physical and psychosocial function of patients and lead to decreased quality of life. Traditionally, psoriasis has been regarded as a disease affecting only the skin and joints. More recently, studies have shown that psoriasis is a systemic inflammatory disorder which can be associated with various comorbidities. In particular, psoriasis is associated with an increased risk of developing severe vascular events such as myocardial infarction and stroke...
October 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29063799/genistein-mechanisms-of-action-for-a-pleiotropic-neuroprotective-agent-in-stroke
#19
Derek A Schreihofer, Anthony Oppong-Gyebi
Genistein is a plant estrogen promoted as an alternative to post-menopausal hormone therapy because of a good safety profile and its promotion as a natural product. Several preclinical studies of cerebral ischemia and other models of brain injury support a beneficial role for genistein in protecting the brain from injury whether administered chronically or acutely. Like estrogen, genistein is a pleiotropic molecule that engages several different mechanisms to enhance brain health, including reduction of oxidative stress, promotion of growth factor signaling, and immune suppression...
October 24, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29058792/association-between-oxidized-low-density-lipoprotein-and-cognitive-impairment-in-ischemic-stroke-patients
#20
Anxin Wang, Jinfeng Liu, Xia Meng, Jingjing Li, Huibing Wang, Youxin Wang, Zhaoping Su, Nan Zhang, Liye Dai, Yongjun Wang, Yilong Wang
BACKGROUND: The association between oxidized low-density lipoprotein (oxLDL) and cognitive impairment is unclear. This study aimed to investigate the potential association between oxLDL and cognitive impairment among patients with acute ischemic stroke. METHODS: We measured the levels of oxLDL and recorded the Mini-Mental State Examination (MMSE) score in acute ischemic stroke patients who were recruited from the Study of Oxidative Stress in Patients with Acute Ischemic Stroke (SOS-Stroke)...
October 23, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
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