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Reactive oxygen species,endothelial damage

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https://www.readbyqxmd.com/read/29677366/the-absence-of-indoleamine-2-3-dioxygenase-inhibits-retinal-capillary-degeneration-in-diabetic-mice
#1
Rooban B Nahomi, Sruthi Sampathkumar, Angela M Myers, Lynda Elghazi, Dawn G Smith, Jie Tang, C Allen Lee, Timothy S Kern, Ram H Nagaraj, Patrice E Fort
Purpose: Loss of retinal capillary endothelial cells and pericytes through apoptosis is an early event in diabetic retinopathy (DR). Inflammatory pathways play a role in early DR, yet the biochemical mechanisms are poorly understood. In this study, we investigated the role of indoleamine 2,3-dioxygenase (IDO), an inflammatory cytokine-inducible enzyme, on retinal endothelial apoptosis and capillary degeneration in the diabetic retina. Methods: IDO was detected in human and mouse retinas by immunohistochemistry or Western blotting...
April 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29655699/scutellarin-protects-against-vascular-endothelial-dysfunction-and-prevents-atherosclerosis-via-antioxidation
#2
Jiao Mo, Renhua Yang, Fan Li, Xiaochao Zhang, Bo He, Yue Zhang, Peng Chen, Zhiqiang Shen
BACKGROUND: Scutellarin is the major constituent responsible for the clinical benefits of Erigeron breviscapus (Vant.) Hand.-Mazz which finds a long history of ethnopharmacological use in Traditional Chinese Medicine. Scutellarin as a pure compound is now under investigation for its protections against various tissue injuries. PURPOSE: This study aims to examine the effects of scutellarin on oxidative stress-induced vascular endothelial dysfunction and endothelial cell damage, and then to evaluate the therapeutic efficacy of scutellarin in preventing atherosclerosis in rats...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29619781/perioperative-implication-of-the-endothelial-glycocalyx
#3
REVIEW
Jong Wook Song, Michael S Goligorsky
The endothelial glycocalyx (EG) is a gel-like layer lining the luminal surface of healthy vascular endothelium. Recently, the EG has gained extensive interest as a crucial regulator of endothelial funtction, including vascular permeability, mechanotransduction, and the interaction between endothelial and circulating blood cells. The EG is degraded by various enzymes and reactive oxygen species upon pro-inflammatory stimulus. Ischemia-reperfusion injury, oxidative stress, hypervolemia, and systemic inflammatory response are responsible for perioperative EG degradation...
April 2018: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/29613814/grape-seed-procyanidins-extract-attenuates-cisplatin-induced-oxidative-stress-and-testosterone-synthase-inhibition-in-rat-testes
#4
Minmin Tian, Fangfang Liu, Han Liu, Qiong Zhang, Lei Li, Xiangbo Hou, Jianxin Zhao, Sheng Li, Xuhong Chang, Yingbiao Sun
Cisplatin (CIS) is widely applied for its antihematological malignancies properties and as antisolid tumors drugs. However, it could cause testicular damage related with oxidative stress and testosterone synthesis disorder. Studies reported that grape seed procyanidins extract (GSPE) could improve CIS induced-testes lesion via scavenging free radicals in animals, although its mechanisms were unclear. Therefore, the purpose of the present study was to explore the antagonistic mechanisms of GSPE on CIS-induced testes lesion...
April 3, 2018: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29610276/the-transcriptional-regulator-ccctc-binding-factor-limits-oxidative-stress-in-endothelial-cells
#5
Anna R Roy, Abdalla Ahmed, Peter V DiStefano, Lijun Chi, Nadiya Khyzha, Niels Galjart, Michael D Wilson, Jason E Fish, Paul Delgado Olguin
The CCCTC-binding factor (CTCF) is a versatile transcriptional regulator required for embryogenesis, but its function in vascular development or in diseases with a vascular component is poorly understood. Here, we found that endothelial Ctcf is essential for mouse vascular development and limits accumulation of reactive oxygen species (ROS). Conditional knockout of Ctcf in endothelial progenitors and their descendants affected embryonic growth, and caused lethality at embryonic day 10.5 owing to defective yolk sac and placental vascular development...
April 2, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29577492/nitric-oxide-synthase-and-oxidative-nitrosative-stress-play-a-key-role-in-placental-infection-by-trypanosoma-cruzi
#6
María Fernanda Triquell, Cintia Díaz-Luján, María Cristina Romanini, Juan Carlos Ramirez, Patricia Paglini-Oliva, Alejandro Gabriel Schijman, Ricardo Emilio Fretes
PROBLEM: The innate immune response of the placenta may participate in the congenital transmission of Chagas disease through releasing reactive oxygen and nitrogen intermediates. METHOD OF STUDY: Placental explants were cultured with 1 × 106 and 1 × 105 trypomastigotes of Tulahuen and Lucky strains and controls without parasites, and with the addition of nitric oxide synthase inhibitor Nω-Nitro-l-arginine methyl ester (l-NAME) and N-acetyl cysteine (NAC) as the reactive oxygen species (ROS) scavenger...
March 25, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29575811/selenadiazole-derivatives-inhibit-angiogenesis-mediated-human-breast-tumor-growth-through-suppressing-vegfr2-mediated-erk-and-akt-signaling-pathway
#7
Haoqiang Lai, Xiaoyan Fu, Chengcheng Sang, Liyuan Hou, Pengju Feng, Xiaoling Li, Tianfeng Chen
Selenadiazole derivatives (SeDs) have been found to show promising application in chemo-/radiotherapy through activating various downstream signaling pathways. However, the functional role of SeDs on angiogenesis, which is pivotal for tumor progression and metastasis, has not been elucidated. In the present study, we have examined the antiangiogenic activities of SeDs and elucidated their underlying mechanisms. The results showed that the as-synthesized SeDs not only enhanced their anti-cancer activities against several human cancer cells, but also showed more potent inhibition on human umbilical vein endothelial cells (HUVECs)...
March 25, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29532774/role-of-family-with-sequence-similarity-3a-in-high-glucose-induced-oxidative-damage-of-human-umbilical-vein-endothelial-cells
#8
Peng-Zhi Liao, Duan Liu, Yue-Hong Zheng
Objective To investigate the role of family with sequence similarity 3A(Fam3A) in high glucose-induced damage of human umbilical vein endothelial cells (HUVECs). Methods HUVECs were divided into control group and high glucose group, which were cultured in endothelial cell medium (ECM) containing 5.5 mmol/L of glucose and ECM containing 33.3 mmol/L of glucose, respectively. Real-time quantitative polymerase chain reaction was used to detect the mRNA expression of Fam3A, whereas the protein expression of Fam3A was detected by enzyme-linked immunosorbent assay...
February 28, 2018: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/29529067/targeted-release-of-stromal-cell-derived-factor-1%C3%AE-by-reactive-oxygen-species-sensitive-nanoparticles-results-in-bone-marrow-stromal-cell-chemotaxis-and-homing-and-repair-of-vascular-injury-caused-by-electrical-burns
#9
Fang He, Peng-Fei Luo, Tao Tang, Fang Zhang, He Fang, Shi-Zhao Ji, Yu Sun, Guo-Sheng Wu, Bo-Han Pan, Zhi-Bao Huo, Guang-Yi Wang, Zhao-Fan Xia
Rapid repair of vascular injury is an important prognostic factor for electrical burns. This repair is achieved mainly via stromal cell-derived factor (SDF)-1α promoting the mobilization, chemotaxis, homing, and targeted differentiation of bone marrow mesenchymal stem cells (BMSCs) into endothelial cells. Forming a concentration gradient from the site of local damage in the circulation is essential to the role of SDF-1α. In a previous study, we developed reactive oxygen species (ROS)-sensitive PPADT nanoparticles containing SDF-1α that could degrade in response to high concentration of ROS in tissue lesions, achieving the goal of targeted SDF-1α release...
2018: PloS One
https://www.readbyqxmd.com/read/29515790/impact-of-glutathione-peroxidase-4-on-cell-proliferation-angiogenesis-and-cytokine-production-in-hepatocellular-carcinoma
#10
Nataliya Rohr-Udilova, Eva Bauer, Gerald Timelthaler, Robert Eferl, Klaus Stolze, Matthias Pinter, Martha Seif, Hubert Hayden, Thomas Reiberger, Rolf Schulte-Hermann, Markus Peck-Radosavljevic, Dagmar Stoiber, Michael Trauner
Insufficient supplementation with the micronutrient selenium and persistent hepatic inflammation predispose to hepatocellular carcinoma (HCC). Inflammation-associated reactive oxygen species attack membrane lipids and form lipid hydroperoxides able to propagate oxidative hepatic damage. Selenium-containing enzyme glutathione peroxidase 4 (GPx4) antagonizes this damage by reducing lipid hydroperoxides to respective hydroxides. However, the role of GPx4 in HCC remains elusive. We generated two human HCC cell lines with stable overexpression of GPx4, performed xenotransplantation into NOD...
February 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29502482/lycium-barbarum-polysaccharide-protects-against-lps-induced-ards-by-inhibiting-apoptosis-oxidative-stress-and-inflammation-in-pulmonary-endothelial-cells
#11
Lan Chen, Wen Li, Di Qi, Daoxin Wang
Acute respiratory distress syndrome (ARDS) is a heterogenous syndrome characterized by diffuse alveolar damage, with an increase in lung endothelial and epithelial permeability. Lycium barbarum polysaccharide (LBP), the most biologically active fraction of wolfberry, possesses antiapoptotic and antioxidative effects in distinct situations. In the present study, the protective effects and potential molecular mechanisms of LBP against lipopolysaccharide (LPS)-induced ARDS were investigated in the mice and in the human pulmonary microvascular endothelial cells (HPMECs)...
March 4, 2018: Free Radical Research
https://www.readbyqxmd.com/read/29499564/impact-of-carbonylation-on-glutathione-peroxidase-1-activity-in-human-hyperglycemic-endothelial-cells
#12
Cheryl S Sultan, Andrea Saackel, Antonia Stank, Thomas Fleming, Maria Fedorova, Ralf Hoffmann, Rebecca C Wade, Markus Hecker, Andreas H Wagner
AIMS: High levels of glucose and reactive carbonyl intermediates of its degradation pathway such as methylglyoxal (MG) may contribute to diabetic complications partly via increased generation of reactive oxygen species (ROS). This study focused on glutathione peroxidase-1 (GPx1) expression and the impact of carbonylation as an oxidative protein modification on GPx1 abundance and activity in human umbilical vein endothelial cells (HUVEC) under conditions of mild to moderate oxidative stress...
February 27, 2018: Redox Biology
https://www.readbyqxmd.com/read/29489344/d-fagomine-attenuates-high-glucose-induced-endothelial-cell-oxidative-damage-by-upregulating-the-expression-of-pgc-1%C3%AE
#13
Chun-Fang, Bo-Bo Zhang, Lin-Han, Cai-Feng Gao, Min-Wang
d-Fagomine, an analogue of 1-deoxynojirimycin (DNJ), has been shown to have hypoglycemic activity. This study is aimed at investigating if d-fagomine could attenuate high glucose-induced oxidative stress in human umbilical vein endothelial cells (HUVECs) and elucidate the underlying mechanism. Our results showed that d-fagomine reduced intracellular reactive oxygen species (ROS) production and malondialdehyde (MDA) levels. It also reversed the decrease of superoxide dismutases (SOD) and glutathione reductase (GR) activity, suggesting an inhibitory effect of d-fagomine on oxidative damage in HUVECs...
February 28, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29483228/vegfr-vascular-endothelial-growth-factor-receptor-inhibition-induces-cardiovascular-damage-via-redox-sensitive-processes
#14
Karla B Neves, Francisco J Rios, Lucas van der Mey, Rheure Alves-Lopes, Alan C Cameron, Massimo Volpe, Augusto C Montezano, Carmine Savoia, Rhian M Touyz
Although VEGF (vascular endothelial growth factor) inhibitors (VEGFIs), are effective anticancer therapies, they cause hypertension through unknown mechanisms. We questioned whether changes in vascular redox state may be important, because VEGF signaling involves nitric oxide (NO) and reactive oxygen species. Molecular mechanisms, including NOS, NADPH oxidase (Nox)-derived reactive oxygen species, antioxidant systems, and vasoconstrictor signaling pathways, were probed in human endothelial cells and vascular smooth muscle exposed to vatalanib, a VEGFI...
February 26, 2018: Hypertension
https://www.readbyqxmd.com/read/29473044/cardiotoxicity-of-anticancer-therapeutics
#15
REVIEW
Jerry Dong, Hong Chen
As cancer therapeutics continues to improve and progress, the adverse side effects associated with anticancer treatments have also attracted more attention and have become extensively explored. Consequently, the importance of posttreatment follow-ups is becoming increasingly relevant to the discussion. Contemporary treatment methods, such as tyrosine kinase inhibitors, anthracycline chemotherapy, and immunotherapy regimens are effective in treating different modalities of cancers; however, these reagents act through interference with DNA replication or prevent DNA repair, causing endothelial dysfunction, generating reactive oxygen species, or eliciting non-specific immune responses...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29462603/lox-1-receptor-a-potential-link-in-atherosclerosis-and-cancer
#16
REVIEW
Silvana Balzan, Valter Lubrano
Altered production of reactive oxygen species (ROS), causing lipid peroxidation and DNA damage, contributes to the progression of atherosclerosis and cancer. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a lectin-like receptor for oxidized low-density lipoproteins (ox-LDL) primarily expressed in endothelial cells and vasculature-rich organs. LOX-1 receptors is a marker for atherosclerosis, and once activated by ox-LDL or other ligands, stimulates the expression of adhesion molecules, pro-inflammatory signaling pathways and proangiogenic proteins, including NF-kB and VEGF, in vascular endothelial cells and macrophages...
February 17, 2018: Life Sciences
https://www.readbyqxmd.com/read/29461122/synchronous-delivery-of-oxygen-and-photosensitizer-for-alleviation-of-hypoxia-tumor-microenvironment-and-dramatically-enhanced-photodynamic-therapy
#17
Xiaomeng Guo, Jiaxin Qu, Chunqi Zhu, Wei Li, Lihua Luo, Jie Yang, Xiaoyi Yin, Qingpo Li, Yongzhong Du, Dawei Chen, Yunqing Qiu, Yan Lou, Jian You
Photosensitizer, proper laser irradiation, and oxygen are essential components for effective photodynamic therapy (PDT) in clinical cancer therapy. However, native hypoxic tumoral microenvironment is a major barrier hindering photodynamic reactions in vivo. Thus, we have prepared biocompatible liposomes by loading complexes of oxygen-carrier (hemoglobin, Hb) and photosensitizer (indocyanine green, ICG) for enhanced PDT against hypoxic tumor. Ideal oxygen donor Hb, which is an oxygen-carried protein in red blood cells, makes such liposome which provide stable oxygen supply...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29439446/the-t2238c-human-atrial-natriuretic-peptide-molecular-variant-and-the-risk-of-cardiovascular-diseases
#18
REVIEW
Speranza Rubattu, Sebastiano Sciarretta, Simona Marchitti, Franca Bianchi, Maurizio Forte, Massimo Volpe
Atrial natriuretic peptide (ANP) is a cardiac hormone which plays important functions to maintain cardio-renal homeostasis. The peptide structure is highly conserved among species. However, a few gene variants are known to fall within the human ANP gene. The variant rs5065 (T2238C) exerts the most substantial effects. The T to C transition at the 2238 position of the gene (13-23% allele frequency in the general population) leads to the production of a 30-, instead of 28-, amino-acid-long α-carboxy-terminal peptide...
February 11, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29438559/oxidative-stress-increases-m1dg-a-major-peroxidation-derived-dna-adduct-in-mitochondrial-dna
#19
Orrette R Wauchope, Michelle M Mitchener, William N Beavers, James J Galligan, Jeannie M Camarillo, William D Sanders, Philip J Kingsley, Ha-Na Shim, Thomas Blackwell, Thong Luong, Mark deCaestecker, Joshua P Fessel, Lawrence J Marnett
Reactive oxygen species (ROS) are formed in mitochondria during electron transport and energy generation. Elevated levels of ROS lead to increased amounts of mitochondrial DNA (mtDNA) damage. We report that levels of M1dG, a major endogenous peroxidation-derived DNA adduct, are 50-100-fold higher in mtDNA than in nuclear DNA in several different human cell lines. Treatment of cells with agents that either increase or decrease mitochondrial superoxide levels leads to increased or decreased levels of M1dG in mtDNA, respectively...
February 9, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29419407/hyperoxia-causes-mitochondrial-fragmentation-in-pulmonary-endothelial-cells-by-increasing-expression-of-pro-fission-proteins
#20
Cui Ma, Andreas M Beyer, Matthew Durand, Anne V Clough, Daling Zhu, Laura Norwood Toro, Maia Terashvili, Johnathan D Ebben, R Blake Hill, Said H Audi, Meetha Medhora, Elizabeth R Jacobs
OBJECTIVE: We explored mechanisms that alter mitochondrial structure and function in pulmonary endothelial cells (PEC) function after hyperoxia. APPROACH AND RESULTS: Mitochondrial structures of PECs exposed to hyperoxia or normoxia were visualized and mitochondrial fragmentation quantified. Expression of pro-fission or fusion proteins or autophagy-related proteins were assessed by Western blot. Mitochondrial oxidative state was determined using mito-roGFP. Tetramethylrhodamine methyl ester estimated mitochondrial polarization in treatment groups...
February 1, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
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