keyword
Keywords Oxidant stress , endothelial d...

Oxidant stress , endothelial damage

https://read.qxmd.com/read/38455648/unveiling-the-pathogenesis-and-therapeutic-approaches-for-diabetic-nephropathy-insights-from-panvascular-diseases
#21
JOURNAL ARTICLE
Xiaoqian Zhang, Jiale Zhang, Yan Ren, Ranran Sun, Xu Zhai
Diabetic nephropathy (DN) represents a significant microvascular complication in diabetes, entailing intricate molecular pathways and mechanisms associated with cardiorenal vascular diseases. Prolonged hyperglycemia induces renal endothelial dysfunction and damage via metabolic abnormalities, inflammation, and oxidative stress, thereby compromising hemodynamics. Concurrently, fibrotic and sclerotic alterations exacerbate glomerular and tubular injuries. At a macro level, reciprocal communication between the renal microvasculature and systemic circulation establishes a pernicious cycle propelling disease progression...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38438703/high-mobility-group-box-1-and-its-related-receptors-potential-therapeutic-targets-for-contrast-induced-acute-kidney-injury
#22
REVIEW
Changhua Mo, Qili Huang, Lixia Li, Yusheng Long, Ying Shi, Zhengde Lu, Ning Wu, Qingkuan Li, Huayuan Zeng, Guihua Li, Lingyue Qiu, Chun Gui, Qingwei Ji
Percutaneous coronary intervention (PCI) is a crucial diagnostic and therapeutic approach for coronary heart disease. Contrast agents' exposure during PCI is associated with a risk of contrast-induced acute kidney injury (CI-AKI). CI-AKI is characterized by a sudden decline in renal function occurring as a result of exposure to intravascular contrast agents, which is associated with an increased risk of poor prognosis. The pathophysiological mechanisms underlying CI-AKI involve renal medullary hypoxia, direct cytotoxic effects, endoplasmic reticulum stress, inflammation, oxidative stress, and apoptosis...
March 5, 2024: International Urology and Nephrology
https://read.qxmd.com/read/38430215/flavonoid-compounds-in%C3%A2-hippophae-rhamnoides%C3%A2-l-%C3%A2-protect-endothelial-cells-from-oxidative-damage-through-the%C3%A2-pi3k-akt-enos%C3%A2-pathway
#23
JOURNAL ARTICLE
Mengyuan Wang, Xingfang Zhang, Zonghao Zhang, Li Tong, Song Yu, Yue Liu, Fang Yang
Sea buckthorn, a traditional medicinal plant, has been used for several years in China for the prevention and treatment of various diseases, a practice closely associated with its significant antioxidant activity. The aim of this study was to investigate the protective effects of sea buckthorn flavonoids on vascular endothelial cells in an oxidative stress environment. We isolated and extracted active compounds from sea buckthorn and investigated their impact on endothelial nitric oxide synthase (eNOS) activity through the PI3K/AKT-eNOS signaling pathway through a combination of network pharmacology and cellular experiments, elucidating the regulatory effects of these compounds on endothelial cell functions...
March 2, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38423472/stepwise-targeted-strategies-for-improving-neurological-function-by-inhibiting-oxidative-stress-levels-and-inflammation-following-ischemic-stroke
#24
JOURNAL ARTICLE
Yi Li, Jun Liao, Liyan Xiong, Zhicheng Xiao, Fei Ye, Yun Wang, Ting Chen, Linzhang Huang, Min Chen, Zhe-Sheng Chen, Tingfang Wang, Chuan Zhang, Ying Lu
Ischemia-reperfusion injury is caused by excessive production of reactive oxygen species (ROS) and inflammation accompanied by ischemic injury symptoms and blood-brain barrier (BBB) dysfunction. This causes neuronal damage, for which no effective treatments or drugs exist. Herein, we provided a stepwise targeted drug delivery strategy and successfully prepared multifunctional ORD@SHp@ANG nanoparticles (NPs) that consist of a stroke homing peptide (DSPE-PEG2000 -SHp), BBB-targeting peptide (DSPE-PEG2000 -ANG), and ROS-responsive Danshensu (salvianic acid A) chain self-assembly...
February 27, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38419293/contribution-of-zinc-accumulation-to-ischemic-brain-injury-and-its-mechanisms-about-oxidative-stress-inflammation-and-autophagy-an-update
#25
JOURNAL ARTICLE
Xueqi Yang, Wei Li, Mao Ding, Ke Jian Liu, Zhifeng Qi, Yongmei Zhao
Ischemic stroke is a leading cause of death and disability worldwide, and presently, there is no effective neuroprotective therapy. Zinc is an essential trace element which plays important physiological roles in the central nervous system. Free zinc concentration is tightly regulated by zinc-related proteins in the brain under normal conditions. Disruption of zinc homeostasis, however, has been found to play an important role in the mechanism of brain injury following ischemic stroke. A large of free zinc releases from storage sites after cerebral ischemia, which affects the functions and survival of nerve cells, including neurons, astrocytes and microglia, resulting in cell death...
February 28, 2024: Metallomics: Integrated Biometal Science
https://read.qxmd.com/read/38417710/blood-based-biomarkers-of-cerebral-small-vessel-disease
#26
REVIEW
Liu-Yun Wu, Yuek Ling Chai, Irwin K Cheah, Rachel S L Chia, Saima Hilal, Thiruma V Arumugam, Christopher P Chen, Mitchell K P Lai
Age-associated cerebral small vessel disease (CSVD) represents a clinically heterogenous condition, arising from diverse microvascular mechanisms. These lead to chronic cerebrovascular dysfunction and carry a substantial risk of subsequent stroke and vascular cognitive impairment in aging populations. Owing to advances in neuroimaging, in vivo visualization of cerebral vasculature abnormities and detection of CSVD, including lacunes, microinfarcts, microbleeds and white matter lesions, is now possible, but remains a resource-, skills- and time-intensive approach...
March 2024: Ageing Research Reviews
https://read.qxmd.com/read/38414287/carnosol-alleviates-sepsis-induced-pulmonary-endothelial-barrier-dysfunction-by-targeting-nuclear-factor-erythroid2-related-factor-2-sirtuin-3-signaling-pathway-to-attenuate-oxidative-damage
#27
JOURNAL ARTICLE
Xingbing Li, Shuo Wang, Minghao Luo, Ming Wang, Shaoping Wu, Chang Liu, Fengxian Wang, Yong Li
Excessive reactive oxygen species production during acute lung injury (ALI) will aggravate the inflammatory process and endothelial barrier dysfunction. Carnosol is a natural phenolic diterpene with antioxidant and anti-inflammatory properties, but its role in treating sepsis-induced ALI remains unclear. This study aims to explore the protective effects and underlying mechanisms of carnosol in sepsis-induced ALI. C57BL/6 mouse were preconditioned with carnosol for 1 h, then the model of lipopolysaccharide (LPS)-induced sepsis was established...
February 27, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38412666/notoginsenoside-fc-a-novel-renoprotective-agent-ameliorates-glomerular-endothelial-cells-pyroptosis-and-mitochondrial-dysfunction-in-diabetic-nephropathy-through-regulating-hmgcs2-pathway
#28
JOURNAL ARTICLE
Yilan Shen, Wei Chen, Kanghong Lin, Haiying Zhang, Xieyi Guo, Xiaoning An, Liu Yang, Niansong Wang, Youhua Xu, Dingkun Gui
BACKGROUND: Diabetic nephropathy (DN) is the primary cause of end-stage renal disease (ESRD), and the therapeutic strategies for DN are limited. Notoginsenoside Fc (Fc), a novel saponin isolated from Panax Notoginseng (PNG), has been reported to alleviate vascular injury in diabetic rats. However, the protective effects of Fc on DN remain unclear. PURPOSE: To investigate the beneficial effects and mechanisms of Fc on DN. METHODS: Db/db mice were treated with 2...
February 10, 2024: Phytomedicine
https://read.qxmd.com/read/38404619/fe-zn-alloy-a-new-biodegradable-material-capable-of-reducing-ros-and-inhibiting-oxidative-stress
#29
JOURNAL ARTICLE
Shuaikang Yang, Weiqiang Wang, Yanan Xu, Yonghui Yuan, Shengzhi Hao
Fe-based biodegradable materials have attracted significant attention due to their exceptional mechanical properties and favorable biocompatibility. Currently, research on Fe-based materials mainly focuses on regulating the degradation rate. However, excessive release of Fe ions during material degradation will induce the generation of reactive oxygen species (ROS), leading to oxidative stress and ferroptosis. Therefore, the control of ROS release and the improvement of biocompatibility for Fe-based materials are very important...
2024: Regenerative Biomaterials
https://read.qxmd.com/read/38397982/specific-multiomic-profiling-in-aortic-stenosis-in-bicuspid-aortic-valve-disease
#30
JOURNAL ARTICLE
Borja Antequera-González, Neus Martínez-Micaelo, Carlos Sureda-Barbosa, Laura Galian-Gay, M Sol Siliato-Robles, Carmen Ligero, Artur Evangelista, Josep M Alegret
INTRODUCTION AND PURPOSE: Bicuspid aortic valve (BAV) disease is associated with faster aortic valve degeneration and a high incidence of aortic stenosis (AS). In this study, we aimed to identify differences in the pathophysiology of AS between BAV and tricuspid aortic valve (TAV) patients in a multiomics study integrating metabolomics and transcriptomics as well as clinical data. METHODS: Eighteen patients underwent aortic valve replacement due to severe aortic stenosis: 8 of them had a TAV, while 10 of them had a BAV...
February 6, 2024: Biomedicines
https://read.qxmd.com/read/38396961/analysis-of-the-model-of-atherosclerosis-formation-in-pig-hearts-as-a-result-of-impaired-activity-of-dna-repair-enzymes
#31
JOURNAL ARTICLE
Robert Paslawski, Paweł Kowalczyk, Urszula Paslawska, Jerzy Wiśniewski, Piotr Dzięgiel, Adrian Janiszewski, Liliana Kiczak, Maciej Zacharski, Barbara Gawdzik, Karol Kramkowski, Andrzej Szuba
Excessive consumption of food rich in saturated fatty acids and carbohydrates can lead to metabolic disturbances and cardiovascular disease. Hyperlipidemia is a significant risk factor for acute cardiac events due to its association with oxidative stress. This leads to arterial wall remodeling, including an increase in the thickness of the intima media complex (IMT), and endothelial dysfunction leading to plaque formation. The decreased nitric oxide synthesis and accumulation of lipids in the wall result in a reduction in the vasodilating potential of the vessel...
February 14, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38392217/protective-potential-of-a-botanical-based-supplement-ingredient-against-the-impact-of-environmental-pollution-on-cutaneous-and-cardiopulmonary-systems-preclinical-study
#32
JOURNAL ARTICLE
Laurent Peno-Mazzarino, Nikita Radionov, Marián Merino, Sonia González, José L Mullor, Jonathan Jones, Nuria Caturla
Air pollution is a growing threat to human health. Airborne pollution effects on respiratory, cardiovascular and skin health are well-established. The main mechanisms of air-pollution-induced health effects involve oxidative stress and inflammation. The present study evaluates the potential of a polyphenol-enriched food supplement ingredient comprising Lippia citriodora , Olea europaea , Rosmarinus officinalis , and Sophora japonica extracts in mitigating the adverse effects of environmental pollution on skin and cardiopulmonary systems...
February 15, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38386637/17-oxime-ethers-of-oxidized-ecdysteroid-derivatives-modulate-oxidative-stress-in-human-brain-endothelial-cells-and-dose-dependently-might-protect-or-damage-the-blood-brain-barrier
#33
JOURNAL ARTICLE
Máté Vágvölgyi, Dávid Laczkó, Ana Raquel Santa-Maria, Judit P Vigh, Fruzsina R Walter, Róbert Berkecz, Mária A Deli, Gábor Tóth, Attila Hunyadi
20-Hydroxyecdysone and several of its oxidized derivatives exert cytoprotective effect in mammals including humans. Inspired by this bioactivity of ecdysteroids, in the current study it was our aim to prepare a set of sidechain-modified derivatives and to evaluate their potential to protect the blood-brain barrier (BBB) from oxidative stress. Six novel ecdysteroids, including an oxime and five oxime ethers, were obtained through regioselective synthesis from a sidechain-cleaved calonysterone derivative 2 and fully characterized by comprehensive NMR techniques revealing their complete 1H and 13C signal assignments...
2024: PloS One
https://read.qxmd.com/read/38382739/the-role-of-thromboinflammation-in-acute-kidney-injury-among-patients-with-septic-coagulopathy
#34
REVIEW
Toshiaki Iba, Julie Helms, Cheryl L Maier, Marcel Levi, Ecaterina Scarlatescu, Jerrold H Levy
Inflammation and coagulation are critical self-defense mechanisms for mitigating infection that can nonetheless induce tissue injury and organ dysfunction. In severe cases, like sepsis, a dysregulated thromboinflammatory response may result in multiorgan dysfunction. Sepsis-associated acute kidney injury (AKI) is a significant contributor to patient morbidity and mortality. The connection between AKI and thromboinflammation is largely due to unique aspects of the renal vasculature. Specifically, the interaction between blood cells with the endothelial, glomerular, and peritubular capillary systems during thromboinflammation reduces oxygen supply to tubular epithelial cells...
February 19, 2024: Journal of Thrombosis and Haemostasis: JTH
https://read.qxmd.com/read/38380477/advanced-age-and-female-sex-protect-cerebral-arteries-from-mitochondrial-depolarization-and-apoptosis-during-acute-oxidative-stress
#35
JOURNAL ARTICLE
Charles E Norton, Rebecca L Shaw, Safa, Beyoncé Dockery, Timothy L Domeier, Steven S Segal
Aging increases reactive oxygen species (ROS) which can impair vascular function and contribute to brain injury. However, aging can also promote resilience to acute oxidative stress. Therefore, we tested the hypothesis that advanced age protects smooth muscle cells (SMCs) and endothelial cells (ECs) of posterior cerebral arteries (PCAs; diameter, ∼80 μm) during exposure to H2 O2 . PCAs from young (4-6 months) and old (20-26 months) male and female C57BL/6 mice were isolated and pressurized (~70 mm Hg) to evaluate cell death, mitochondrial membrane potential (ΔΨm ), ROS production, and [Ca2+ ]i in response to H2 O2 (200 μM, 50 min)...
February 21, 2024: Aging Cell
https://read.qxmd.com/read/38379112/advancing-stroke-therapy-a-deep-dive-into-early-phase-of-ischemic-stroke-and-recanalization
#36
REVIEW
Qianyan He, Yueqing Wang, Cheng Fang, Ziying Feng, Meifang Yin, Juyang Huang, Yinzhong Ma, Zhizhun Mo
Ischemic stroke, accounting for the majority of stroke events, significantly contributes to global morbidity and mortality. Vascular recanalization therapies, namely intravenous thrombolysis and mechanical thrombectomy, have emerged as critical interventions, yet their success hinges on timely application and patient-specific factors. This review focuses on the early phase pathophysiological mechanisms of ischemic stroke and the nuances of recanalization. It highlights the dual role of neutrophils in tissue damage and repair, and the critical involvement of the blood-brain barrier (BBB) in stroke outcomes...
February 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38378459/the-significance-of-glycocalyx-in-surgery
#37
JOURNAL ARTICLE
L Hána, J Kočí, R Pohnán, D Řehák, D Astapenko
INTRODUCTION: Surgical treatment is associated with an unwanted response of the organism to the so-called surgical trauma. This response is called surgical stress. Ischaemia-reperfusion injury is one of essential causes of tissue damage. It comprises functional and structural changes in tissue that occur after the restoration of circulation, after an episode of ischaemia. Necrosis of irreversibly changed cells and endothelial and mitochondrial-induced tissue swelling occur. METHODS: Physiology, pathophysiology of endothelial glycocalyx: Endothelial glycocalyx is a 0...
2024: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://read.qxmd.com/read/38370153/the-potential-effect-of-natural-antioxidants-on-endothelial-dysfunction-associated-with-arterial-hypertension
#38
REVIEW
Rosamaria Caminiti, Cristina Carresi, Rocco Mollace, Roberta Macrì, Federica Scarano, Francesca Oppedisano, Jessica Maiuolo, Maria Serra, Stefano Ruga, Saverio Nucera, Annamaria Tavernese, Micaela Gliozzi, Vincenzo Musolino, Ernesto Palma, Carolina Muscoli, Speranza Rubattu, Maurizio Volterrani, Massimo Federici, Massimo Volpe, Vincenzo Mollace
Arterial hypertension represents a leading cause of cardiovascular morbidity and mortality worldwide, and the identification of effective solutions for treating the early stages of elevated blood pressure (BP) is still a relevant issue for cardiovascular risk prevention. The pathophysiological basis for the occurrence of elevated BP and the onset of arterial hypertension have been widely studied in recent years. In addition, consistent progress in the development of novel, powerful, antihypertensive drugs and their appropriate applications in controlling BP have increased our potential for successfully managing disease states characterized by abnormal blood pressure...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38368111/improving-impact-of-heparan-sulfate-on-the-endothelial-glycocalyx-abnormalities-in-atherosclerosis-as-revealed-by-glycan-protein-interactome
#39
JOURNAL ARTICLE
Qingqing Chen, Xiaohui Xu, Shaoshuai Xie, Anran Sheng, Naihan Han, Zhenyu Tian, Xiaowei Wang, Fuchuan Li, Robert J Linhardt, Fuming Zhang, Lan Jin, Qunye Zhang, Lianli Chi
Endothelial dysfunction induced by oxidative stress is an early predictor of atherosclerosis, which can cause various cardiovascular diseases. The glycocalyx layer on the endothelial cell surface acts as a barrier to maintain endothelial biological function, and it can be impaired by oxidative stress. However, the mechanism of glycocalyx damage during the development of atherosclerosis remains largely unclear. Herein, we established a novel strategy to address these issues from the glycomic perspective that has long been neglected...
April 15, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/38367275/restoration-of-blood-vessel-regeneration-in-the-era-of-combination-sglt2i-and-glp-1ra-therapy-for-diabetes-and-obesity
#40
JOURNAL ARTICLE
Daniella C Terenzi, Ehab Bakbak, Hwee Teoh, Aishwarya Krishnaraj, Pankaj Puar, Ori D Rotstein, Francesco Cosentino, Ronald M Goldenberg, Subodh Verma, David A Hess
Ischaemic cardiovascular diseases, including peripheral and coronary artery disease, myocardial infarction, and stroke, remain major comorbidities for individuals with type 2 diabetes (T2D) and obesity. During cardiometabolic chronic disease (CMCD), hyperglycaemia and excess adiposity elevate oxidative stress and promote endothelial damage, alongside an imbalance in circulating pro-vascular progenitor cells that mediate vascular repair. Individuals with CMCD demonstrate pro-vascular 'regenerative cell exhaustion' (RCE) characterized by excess pro-inflammatory granulocyte precursor mobilization into the circulation, monocyte polarization towards pro-inflammatory vs...
February 17, 2024: Cardiovascular Research
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