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https://www.readbyqxmd.com/read/28441825/-progressive-cavitating-leukoencephalopathy-four-cases-and-literatures-review
#1
C H Ren, F Fang, H Cheng, C H Ding, C H Chen, Y J Zhang, D M Shen
Objective: To analyze the clinical and genetic features of progressive cavitating leukoencephalopathy (PCL). Method: The data of clinical and genetic features of 4 PCL patients diagnosed by Beijing Children's Hospital between January 2015 and January 2016 were analyzed. The cases with complete clinical data retrieved on literature search at China National Knowledge Infrastructure, Wanfang Data Knowledge Service Platform and PubMed (up to August 2016) by using search terms of"NDUFV1" ,"NDUFS1" , or"leukoencephalopathy" , were summarized...
April 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28440246/what-s-new-for-us-in-strabismus
#2
Pradeep Sharma, Nripen Gaur, Swati Phuljhele, Rohit Saxena
Strabismus is one of the most challenging subspecialties encountered in the field of ophthalmology. The concept of etiology of strabismus is being advanced with the development of newer imaging modalities and increased understanding of the genetics of strabismus. Imaging is also being used to aid in the planning of strabismus surgery. Newer horizons are being explored in the amblyopia management. The good old eye-pad is being replaced with the iPad. Early detection of loss of stereopsis is being used to decide the timing for strabismus surgery...
March 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28433442/strabismus-and-mental-disorders-among-israeli-adolescents
#3
Ilan Merdler, Moshe Giladi, Nir Sorkin, Shachar Shapira, Eran Galili, Alexander Margulis, Tzfanya Korach, Ayal Hassidim
PURPOSE: To assess the association between strabismus and mental disorders in adolescents. METHODS: This case-control study included 662,641 Israeli teenagers that underwent medical evaluation by the Israel Defense Force as part of the preconscription assessment between 2005 and 2013. The association between common mental disorders (anxiety disorder, mood disorder, adjustment disorder, and attention deficit hyperactivity disorder [ADHD]) and either uncorrected strabismus or corrected strabismus was examined...
April 19, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28431435/regional-extent-of-peripheral-suppression-in-amblyopia
#4
Raiju J Babu, Simon Clavagnier, William R Bobier, Benjamin Thompson, Robert F Hess
Purpose: Previously, we have mapped amblyopic eye suppression within the central 20° of the visual field and observed a gradient of suppression that is strongest in central vision and weakens with increasing eccentricity. In this study, using a large dichoptic display, we extend our novel suppression mapping approach further into the periphery (from 20°-60°) to assess whether suppression continues to decline with eccentricity or plateaus. Methods: Sixteen participants with amblyopia (10 with strabismus, 6 with anisometropia without strabismus; mean age: 37...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28426269/2016-international-orthoptic-congress-burian-lecture-folklore-or-evidence
#5
Anna M Horwood
The theme of the 2016 Burian Lecture is how our understanding of strabismus has been changed by the research carried out in our laboratory in Reading over the years. Accommodation and convergence are fundamental to orthoptics, but actual responses have often been very different compared to what we had expected. This paper outlines how our laboratory's understanding of common issues such as normal development of accommodation and convergence, their linkage, intermittent strabismus, anisometropia, orthoptic exercises, and risk factors for strabismus have changed...
April 20, 2017: Strabismus
https://www.readbyqxmd.com/read/28425235/a-study-on-the-validity-and-reliability-of-the-amblyopia-andstrabismus-questionnaire-a-sq-in-turkish
#6
Halise Çoşkun, Sevinç Taştan, Emine Iyigün, Fatih Mehmet Mutlu, Osman Melih Ceylan, Halil İbrahim Altinsoy
BACKGROUND/AIM: This study aims to evaluate the reliability and validity of the Amblyopia and Strabismus Questionnaire (AandSQ) that is translated into Turkish. MATERIALS AND METHODS: This is a methodological study. A total of 149 patients took part in the survey research between December 2012 and June 2014 in an university hospital, and 37 were retested. Cronbach's alpha coefficient was used for the questionnaire's reliability analysis. RESULTS: Cronbach's alpha coefficients for the subscales of fear of losing the better eye, distance estimation, visual disorientation, double vision, and social contact and appearance were found to be 0...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28418222/modified-loop-myopexy-technique-for-severe-high-myopic-strabismus-fixus
#7
Leilei Zou, Shuai Liu, Rui Liu, Yao Jing, Yan Liu, Jing Lin, Hong Liu
IMPORTANCE: This study introduces a modified loop myopexy technique for severe high myopic strabismus fixus (MSF). BACKGROUND: To evaluate the surgical results of loop myopexy with or without medial rectus (MR) recession for the treatment of patients with MSF. DESIGN: A retrospective study in a Chinese teaching hospital. PARTICIPANTS: Data was collected from 25 MSF patients (33 eyes) with restriction in both abduction and sursumduction...
April 18, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28414562/a-review-of-cochrane-systematic-reviews-of-interventions-relevant-to-orthoptic-practice
#8
Fiona J Rowe, Sue Elliott, Iris Gordon, Anupa Shah
AIM: To present an overview of the range of systematic reviews on intervention trials pertinent to orthoptic practice, produced by the Cochrane Eyes and Vision group (CEV). METHODS: We searched the 2016 Cochrane Library database (31.03.2016) to identify completed reviews and protocols of direct relevance to orthoptic practice. These reviews are currently completed and published, available on www.thecochranelibrary.com (free to UK health employees) or via the CEV website (http://eyes...
April 17, 2017: Strabismus
https://www.readbyqxmd.com/read/28412799/-long-term-outcomes-after-cataract-surgery-in-infants-with-congenital-cataract
#9
J Y Qi, W Xiao, M Y Wang, D X Zhao, W Pu
Objective: To observe the long-term outcomes after congenital cataract surgery performed prior to 36 months of age. Methods: A retrospective case study was conducted. Thirty-two cases (57 eyes) of congenital cataract were included from January 2004 to January 2012. All patients received intraocular lens (IOL) implantation with posterior continuous curvilinear capsulorhexies and anterior vitrectomy after cataract extraction and were followed up. At the last visit, the best corrected visual acuity (BCVA) was determined and postoperative complications were evaluated during follow-up with a longest time of 13 years...
April 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28409024/response-to-comment-on-exotropia-is-the-main-pattern-of-childhood-strabismus-surgery-in-the-south-of-china-a-six-year-clinical-review
#10
COMMENT
Xinping Yu, Zhouduo Ji, Huanyun Yu, Meiping Xu, Jinling Xu
No abstract text is available yet for this article.
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28405481/factors-affecting-contrast-sensitivity-in-healthy-individuals-a-pilot-study
#11
Arzu Seyhan Karatepe, Süheyla Köse, Sait Eğrilmez
OBJECTIVES: To determine the demographic and ocular features affecting contrast sensitivity levels in healthy individuals. MATERIALS AND METHODS: Seventy-four eyes of 37 subjects (7-65 years old) with refractive errors less than 1.0 diopter, no history of ocular surgery, and 20/20 visual acuity were included in the study. The participants were divided by age into three groups: group 1, 7-19 years, n=11; group 2, 20-49 years, n=15; and group 3, 50-65 years, n=11...
April 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28404829/neural-mechanisms-of-oculomotor-abnormalities-in-the-infantile-strabismus-syndrome
#12
Mark M G Walton, Adam C Pallus, Jerome Fleuriet, Michael J Mustari, Kristina Tarczy-Hornoch
Infantile strabismus is characterized by numerous visual and oculomotor abnormalities. Recently non-human primate models of infantile strabismus have been established, with characteristics that closely match those observed in human patients. This has made it possible to study the neural basis for visual and oculomotor symptoms in infantile strabismus. In this review, we consider the available evidence for neural abnormalities in structures related to oculomotor pathways ranging from visual cortex to oculomotor nuclei...
April 12, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28404522/observations-on-the-relationship-between-anisometropia-amblyopia-and-strabismus
#13
Earl L Smith, Li-Fang Hung, Baskar Arumugam, Janice M Wensveen, Yuzo M Chino, Ronald S Harwerth
We investigated the potential causal relationships between anisometropia, amblyopia and strabismus, specifically to determine whether either amblyopia or strabismus interfered with emmetropization. We analyzed data from non-human primates that were relevant to the co-existence of anisometropia, amblyopia and strabismus in children. We relied on interocular comparisons of spatial vision and refractive development in animals reared with 1) monocular form deprivation; 2) anisometropia optically imposed by either contact lenses or spectacle lenses; 3) organic amblyopia produced by laser ablation of the fovea; and 4) strabismus that was either optically imposed with prisms or produced by either surgical or pharmacological manipulation of the extraocular muscles...
April 18, 2017: Vision Research
https://www.readbyqxmd.com/read/28402530/mutations-in-the-human-robo1-gene-in-pituitary-stalk-interruption-syndrome
#14
Anu Bashamboo, Joelle Bignon-Topalovic, Nasser Moussi, Ken McElreavey, Raja Brauner
Context: Pituitary stalk interruption syndrome (PSIS) is characterised by a thin or absent pituitary stalk usually in association with an ectopic posterior pituitary and hypoplasia/aplasia of the anterior pituitary. Associated phenotypes include varied ocular anomalies, hypoglycemia, micropenis/cryptorchidism, growth failure or combined pituitary hormone deficiencies. Although genetic causes have been identified, they explain only around 5% of PSIS cases. Objective: To identify genetic causes of PSIS by exome sequencing...
April 11, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28399055/long-term-visual-and-ocular-sequelae-in-patients-with-congenital-cytomegalovirus-infection
#15
Haoxing Jin, Gail J Demmler-Harrison, David K Coats, Evelyn A Paysse, Amit Bhatt, Jane C Edmond, Kimberly G Yen, Paul Steinkuller, Jerry Miller
BACKGROUND: Cytomegalovirus (CMV) is the most common congenital viral infection in the United States. Visual and ocular sequelae in adolescents and adults who are congenitally infected with CMV have not been well studied. Better understanding of the long-term visual and ocular sequelae can help with early detection, intervention, and appropriate educational accommodations. METHODS: This study evaluated 237 (77 symptomatic, 109 asymptomatic, and 51 control) patients who underwent a series of age-appropriate ophthalmologic, audiologic, and neurodevelopmental examinations from 1982 to 2013...
April 10, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28391287/identification-of-2-potentially-relevant-gene-mutations-involved-in-strabismus-using-whole-exome-sequencing
#16
Xiangrong Min, Haiying Fan, Guiqiu Zhao, Guixiang Liu
BACKGROUND The etiology of strabismus has a genetic component. Our study aimed to localize the candidate causative gene mutant in a Chinese family with strabismus and to describe its underlying etiology. MATERIAL AND METHODS Genomic DNA was extracted from the affected individual and his parents in a Chinese pedigree with strabismus. The resulting exomes were sequenced by whole-exome sequencing. After variant calling and filtering, the candidate causative gene mutations were selected for the rarity and predicted damaging effect, which complied with the model of recessive disease transmission...
April 9, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28388718/abobotulinumtoxina-a-25-year-history
#17
Gary D Monheit, Andy Pickett
During the late 1960s and early 1970s, Alan Scott showed that intramuscular injections of botulinum toxin (BoNT) corrected nonaccommodative strabismus without resorting to surgery. The UK doctors who trained with Scott soon realized the significant potential offered by BoNT type A as a therapeutic option for several difficult-to-treat diseases. This led to a collaboration between these pioneering clinicians and the Centre for Applied Microbiology and Research at Porton Down, United Kingdom, and, in turn, to the development and commercialization of abobotulinumtoxinA as Dysport (Dystonia/Porton Down; Ipsen Biopharm Ltd...
May 1, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/28388348/geriatric-patients-are-predisposed-to-strabismus-following-thyroid-related-orbital-decompression-surgery-a-multivariate-analysis
#18
Chris Y Wu, Alon Kahana
Geriatric patients (age ≥ 65) are prone to complications after surgery and are at risk for severe thyroid eye disease (TED). In this study, we aim to identify preoperative demographic and TED patterns associated with geriatric patients who underwent decompression surgery, to examine the effect of age on postoperative strabismus rates, and to identify factors that may contribute to postoperative strabismus in the geriatric subgroup. We retrospectively reviewed patients who underwent thyroid-related orbital decompression surgery at the Kellogg Eye Center, University of Michigan, between 1999 and 2014...
April 2017: Orbit
https://www.readbyqxmd.com/read/28385301/marshall-m-parks-memorial-lecture-ocular-motor-misbehavior-in-children-where-neuro-ophthalmology-meets-strabismus
#19
REVIEW
Michael C Brodsky
Clinical diagnosis has been supplemented by neuroimaging advances, genetic discoveries, and molecular research to generate new neurobiological discoveries pertaining to early maldevelopment of ocular motor control systems. In this focused review, I examine recent paradigm shifts that have transformed our understanding of pediatric ocular motor disease at the prenuclear and infranuclear levels. The pathogenesis of complex ocular motor disorders, such as paradoxical pupillary constriction to darkness, benign tonic upgaze of infancy, congenital fibrosis syndrome, and the constellation of unique eye movements that accompany Joubert syndrome, are elucidated...
April 3, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28384899/health-related-quality-of-life-hrqol-in-young-adults-with-strabismus-in-india
#20
Surendra P Sah, Indra P Sharma, Monica Chaudhry, Mousumi Saikia
INTRODUCTION: Strabismus has negative psycho-social and functional effects in adults. The impact can be minimised with surgery. However, in a low-income setting, it is important to evaluate the level of impact and prioritise the target population for intervention. The Adult Strabismus (AS-20) questionnaire is a reliable tool for assessment of Health-Related Quality of Life (HRQoL) in strabismic adults. AIM: To assess the HRQoL in young adults with manifest strabismus through psychosocial and functional scores according to gender and direction of deviation using the AS-20 questionnaire...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
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