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https://www.readbyqxmd.com/read/27343741/canadian-cardiovascular-society-guidelines-for-evaluation-and-management-of-cardiovascular-complications-of-cancer-therapy
#1
Sean A Virani, Susan Dent, Christine Brezden-Masley, Brian Clarke, Margot K Davis, Davinder S Jassal, Christopher Johnson, Julie Lemieux, Ian Paterson, Igal A Sebag, Christine Simmons, Jeffrey Sulpher, Kishore Thain, Paaldinesh Thavendiranathan, Jason R Wentzell, Nola Wurtele, Marc André Côté, Nowell M Fine, Haissam Haddad, Bradley D Hayley, Sean Hopkins, Anil A Joy, Daniel Rayson, Ellamae Stadnick, Lynn Straatman
Modern treatment strategies have led to improvements in cancer survival, however, these gains might be offset by the potential negative effect of cancer therapy on cardiovascular health. Cardiotoxicity is now recognized as a leading cause of long-term morbidity and mortality among cancer survivors. This guideline, authored by a pan-Canadian expert group of health care providers and commissioned by the Canadian Cardiovascular Society, is intended to guide the care of cancer patients with established cardiovascular disease or those at risk of experiencing toxicities related to cancer treatment...
July 2016: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/26220066/longitudinal-changes-in-multiple-biomarkers-are-associated-with-cardiotoxicity-in-breast-cancer-patients-treated-with-doxorubicin-taxanes-and-trastuzumab
#2
Mary Putt, Virginia Shalkey Hahn, James L Januzzi, Heloisa Sawaya, Igal A Sebag, Juan Carlos Plana, Michael H Picard, Joseph R Carver, Elkan F Halpern, Irene Kuter, Jonathan Passeri, Victor Cohen, Jose Banchs, Randolph P Martin, Robert E Gerszten, Marielle Scherrer-Crosbie, Bonnie Ky
BACKGROUND: Biomarkers may play an important role in identifying patients at risk for cancer therapy cardiotoxicity. Our objectives were to define the patterns of change in biomarkers with cancer therapy and their associations with cardiotoxicity. METHODS: In a multicenter cohort of 78 breast cancer patients undergoing doxorubicin and trastuzumab therapy, 8 biomarkers were evaluated at baseline and every 3 months over a maximum follow-up of 15 months. These biomarkers, hypothesized to be mechanistically relevant to cardiotoxicity, included high-sensitivity cardiac troponin I (hs-cTnI), high-sensitivity C-reactive protein (hsCRP), N-terminal pro-B-type natriuretic peptide (NT-proBNP), growth differentiation factor 15 (GDF-15), myeloperoxidase (MPO), placental growth factor (PlGF), soluble fms-like tyrosine kinase receptor-1 (sFlt-1), and galectin 3 (gal-3)...
September 2015: Clinical Chemistry
https://www.readbyqxmd.com/read/25772019/time-trends-of-left-ventricular-ejection-fraction-and%C3%A2-myocardial-deformation-indices-in-a-cohort-of%C3%A2-women-with-breast-cancer-treated-with-anthracyclines-taxanes-and-trastuzumab
#3
MULTICENTER STUDY
Timothy C Tan, Souhila Bouras, Heloisa Sawaya, Igal A Sebag, Victor Cohen, Michael H Picard, Jonathan Passeri, Irene Kuter, Marielle Scherrer-Crosbie
BACKGROUND: Trastuzumab, a HER2 monoclonal antibody, has transformed the prognosis of patients with the aggressive HER2-positive breast cancer type. Trastuzumab augments the cardiotoxic effects of anthracyclines, but its effect is thought to be at least partially reversible. The objective of this study was to examine the time trends of left ventricular (LV) size and function in a cohort of women treated with anthracyclines and trastuzumab. METHODS: Twenty-nine patients >18 years of age with first-time breast cancer treated with anthracyclines and trastuzumab were monitored using echocardiography before, at the completion of, and at a median follow-up of 24...
May 2015: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/25265974/transcatheter-heart-valve-failure-a-systematic-review
#4
REVIEW
Darren Mylotte, Ali Andalib, Pascal Thériault-Lauzier, Magdalena Dorfmeister, Mina Girgis, Waleed Alharbi, Michael Chetrit, Christos Galatas, Samuel Mamane, Igal Sebag, Jean Buithieu, Luc Bilodeau, Benoit de Varennes, Kevin Lachapelle, Ruediger Lange, Giuseppe Martucci, Renu Virmani, Nicolo Piazza
AIMS: A comprehensive description of transcatheter heart valve (THV) failure has not been performed. We undertook a systematic review to investigate the aetiology, diagnosis, management, and outcomes of THV failure. METHODS AND RESULTS: The systematic review was performed in accordance with the PRISMA guidelines using EMBASE, MEDLINE, and Scopus. Between December 2002 and March 2014, 70 publications reported 87 individual cases of transcatheter aortic valve implantation (TAVI) failure...
June 1, 2015: European Heart Journal
https://www.readbyqxmd.com/read/25239940/expert-consensus-for-multimodality-imaging-evaluation-of-adult-patients-during-and-after-cancer-therapy-a-report-from-the-american-society-of-echocardiography-and-the-european-association-of-cardiovascular-imaging
#5
Juan Carlos Plana, Maurizio Galderisi, Ana Barac, Michael S Ewer, Bonnie Ky, Marielle Scherrer-Crosbie, Javier Ganame, Igal A Sebag, Deborah A Agler, Luigi P Badano, Jose Banchs, Daniela Cardinale, Joseph Carver, Manuel Cerqueira, Jeanne M DeCara, Thor Edvardsen, Scott D Flamm, Thomas Force, Brian P Griffin, Guy Jerusalem, Jennifer E Liu, Andreia Magalhães, Thomas Marwick, Liza Y Sanchez, Rosa Sicari, Hector R Villarraga, Patrizio Lancellotti
No abstract text is available yet for this article.
October 2014: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/25172399/expert-consensus-for-multimodality-imaging-evaluation-of-adult-patients-during-and-after-cancer-therapy-a-report-from-the-american-society-of-echocardiography-and-the-european-association-of-cardiovascular-imaging
#6
Juan Carlos Plana, Maurizio Galderisi, Ana Barac, Michael S Ewer, Bonnie Ky, Marielle Scherrer-Crosbie, Javier Ganame, Igal A Sebag, Deborah A Agler, Luigi P Badano, Jose Banchs, Daniela Cardinale, Joseph Carver, Manuel Cerqueira, Jeanne M DeCara, Thor Edvardsen, Scott D Flamm, Thomas Force, Brian P Griffin, Guy Jerusalem, Jennifer E Liu, Andreia Magalhães, Thomas Marwick, Liza Y Sanchez, Rosa Sicari, Hector R Villarraga, Patrizio Lancellotti
No abstract text is available yet for this article.
September 2014: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/24291281/early-increases-in-multiple-biomarkers-predict-subsequent-cardiotoxicity-in-patients-with-breast-cancer-treated-with-doxorubicin-taxanes-and-trastuzumab
#7
MULTICENTER STUDY
Bonnie Ky, Mary Putt, Heloisa Sawaya, Benjamin French, James L Januzzi, Igal A Sebag, Juan Carlos Plana, Victor Cohen, Jose Banchs, Joseph R Carver, Susan E Wiegers, Randolph P Martin, Michael H Picard, Robert E Gerszten, Elkan F Halpern, Jonathan Passeri, Irene Kuter, Marielle Scherrer-Crosbie
OBJECTIVES: The aim of this study was to determine if individual or multiple biomarkers are associated with cardiotoxicity in patients with breast cancer undergoing cancer therapy. BACKGROUND: Current methods to identify patients at risk for cardiotoxicity from cancer therapy are inadequate. METHODS: We measured 8 biomarkers in a multicenter cohort of 78 patients with breast cancer undergoing doxorubicin and trastuzumab therapy: ultrasensitive troponin I (TnI), high-sensitivity C-reactive protein (CRP), N-terminal pro-B-type natriuretic peptide (NT-proBNP), growth differentiation factor (GDF)-15, myeloperoxidase (MPO), placental growth factor (PlGF), soluble fms-like tyrosine kinase receptor (sFlt)-1, and galectin (gal)-3...
March 4, 2014: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/23998694/expert-consensus-for-multi-modality-imaging-evaluation-of-cardiovascular-complications-of-radiotherapy-in-adults-a-report-from-the-european-association-of-cardiovascular-imaging-and-the-american-society-of-echocardiography
#8
Patrizio Lancellotti, Vuyisile T Nkomo, Luigi P Badano, Jutta Bergler-Klein, Jutta Bergler, Jan Bogaert, Laurent Davin, Bernard Cosyns, Philippe Coucke, Raluca Dulgheru, Thor Edvardsen, Oliver Gaemperli, Maurizio Galderisi, Brian Griffin, Paul A Heidenreich, Koen Nieman, Juan C Plana, Steven C Port, Marielle Scherrer-Crosbie, Ronald G Schwartz, Igal A Sebag, Jens-Uwe Voigt, Samuel Wann, Phillip C Yang
Cardiac toxicity is one of the most concerning side effects of anti-cancer therapy. The gain in life expectancy obtained with anti-cancer therapy can be compromised by increased morbidity and mortality associated with its cardiac complications. While radiosensitivity of the heart was initially recognized only in the early 1970s, the heart is regarded in the current era as one of the most critical dose-limiting organs in radiotherapy. Several clinical studies have identified adverse clinical consequences of radiation-induced heart disease (RIHD) on the outcome of long-term cancer survivors...
September 2013: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/23984849/cardiac-structure-function-protein-expression-and-dna-methylation-are-changed-in-adult-female-mice-exposed-to-diethylstilbestrol-in-utero
#9
Rami Haddad, Amanda Kasneci, Igal A Sebag, Lorraine E Chalifour
The detrimental effects of in utero exposure to the non-steroidal estrogen diethylstilbestrol (DES) are particularly marked in women. Fetal hearts express estrogen receptors, making them potentially responsive to DES. To examine whether gestational exposure to DES would impact the heart, we exposed pregnant C57bl/6n dams to DES (0.1, 1.0, and 10.0 μg·(kg body mass)(-1)·day(-1)) on gestation days 11.5-14.5, and examined the measured cardiac structure/function and calcium homeostasis protein expression in adult females...
September 2013: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/23981771/human-resistin-in-chemotherapy-induced-heart-failure-in-humanized-male-mice-and-in-women-treated-for-breast-cancer
#10
Daniel R Schwartz, Erika R Briggs, Mohammed Qatanani, Heloisa Sawaya, Igal A Sebag, Michael H Picard, Marielle Scherrer-Crosbie, Mitchell A Lazar
Resistin is a circulating mediator of insulin resistance mainly expressed in human monocytes and responsive to inflammatory stimuli. Recent clinical studies have connected elevated resistin levels with the development and severity of heart failure. To further our understanding of the role of human resistin in heart failure, we studied a humanized mouse model lacking murine resistin but transgenic for the human Retn gene (Hum-Retn mice), which exhibits basal and inflammation-stimulated resistin levels similar to humans...
November 2013: Endocrinology
https://www.readbyqxmd.com/read/23847385/expert-consensus-for-multi-modality-imaging-evaluation-of-cardiovascular-complications-of-radiotherapy-in-adults-a-report-from-the-european-association-of-cardiovascular-imaging-and-the-american-society-of-echocardiography
#11
Patrizio Lancellotti, Vuyisile T Nkomo, Luigi P Badano, Jutta Bergler-Klein, Jan Bogaert, Laurent Davin, Bernard Cosyns, Philippe Coucke, Raluca Dulgheru, Thor Edvardsen, Oliver Gaemperli, Maurizio Galderisi, Brian Griffin, Paul A Heidenreich, Koen Nieman, Juan C Plana, Steven C Port, Marielle Scherrer-Crosbie, Ronald G Schwartz, Igal A Sebag, Jens-Uwe Voigt, Samuel Wann, Phillip C Yang
Cardiac toxicity is one of the most concerning side effects of anti-cancer therapy. The gain in life expectancy obtained with anti-cancer therapy can be compromised by increased morbidity and mortality associated with its cardiac complications. While radiosensitivity of the heart was initially recognized only in the early 1970s, the heart is regarded in the current era as one of the most critical dose-limiting organs in radiotherapy. Several clinical studies have identified adverse clinical consequences of radiation-induced heart disease (RIHD) on the outcome of long-term cancer survivors...
August 2013: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/23487556/cardiotoxicity-of-cancer-therapeutics-current-issues-in-screening-prevention-and-therapy
#12
Richard J Sheppard, Jenna Berger, Igal A Sebag
In the context of modern cancer chemotherapeutics, cancer survivors are living longer and being exposed to potential comorbidities related to non-cancer side effects of such treatments. With close monitoring of cancer patients receiving potentially cardiotoxic medical therapies, oncologists, and cardiologists alike are identifying patients in both clinical and subclinical phases of cardiovascular disease related to such chemotherapies. Specifically, cardiotoxicity at the level of the myocardium and potential for the development of heart failure are becoming a growing concern with increasing survival of cancer patients...
2013: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/23418087/lifelong-exposure-to-bisphenol-a-alters-cardiac-structure-function-protein-expression-and-dna-methylation-in-adult-mice
#13
Bhavini B Patel, Mohamad Raad, Igal A Sebag, Lorraine E Chalifour
Bisphenol A (BPA) is an estrogenizing endocrine disruptor compound of concern. Our objective was to test whether lifelong BPA would impact cardiac structure/function, calcium homeostasis protein expression, and the DNA methylation of cardiac genes. We delivered 0.5 and 5.0 µg/kg/day BPA lifelong from gestation day 11 or 200 µg/kg/day from gestation day 11 to postnatal day 21 via the drinking water to C57bl/6n mice. BPA 5.0 males and females had increased body weight, body mass index, body surface area, and adiposity...
May 2013: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/23181280/the-impact-of-doxorubicin-and-dexrazoxane-injection-of-prepubertal-female-rats-on-pregnancy-outcome-and-cardiac-function-postpartum
#14
Annie Calvé, William Noiles, Igal A Sebag, Lorraine E Chalifour
Childhood cancer survivors can develop significant cardiac dysfunction in adulthood as a consequence of their cancer treatment. Studies have linked heart failure during pregnancy to childhood doxorubicin (DOX) exposure. We hypothesized that DOX injection would reduce cardiac function peripartum and that DOX-treated dams would show greater cardiac remodeling postweaning. Weanling female Sprague-Dawley rats were injected with phospate-buffered saline, DOX (3 mg/kg), or DOX plus the cardioprotectant dexrazoxane (DEX; 60 mg/kg) and followed for 2 pregnancies...
November 2012: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/23142472/gestational-exposure-to-diethylstilbestrol-alters-cardiac-structure-function-protein-expression-and-dna-methylation-in-adult-male-mice-progeny
#15
Rami Haddad, Amanda Kasneci, Kathryn Mepham, Igal A Sebag, Lorraine E Chalifour
Pregnant women, and thus their fetuses, are exposed to many endocrine disruptor compounds (EDCs). Fetal cardiomyocytes express sex hormone receptors making them potentially susceptible to re-programming by estrogenizing EDCs. Diethylstilbestrol (DES) is a proto-typical, non-steroidal estrogen. We hypothesized that changes in adult cardiac structure/function after gestational exposure to the test compound DES would be a proof in principle for the possibility of estrogenizing environmental EDCs to also alter the fetal heart...
January 1, 2013: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/23062663/right-ventricular-end-diastolic-wall-stress-does-it-impact-on-right-atrial-size-and-does-it-differ-in-right-ventricular-pressure-vs-volume-loading-conditions
#16
Karima Addetia, Igal A Sebag, Ariane Marelli, Doan Hoa Do, Jon Afilalo, Guisseppe Martucci, Judith Therrien
BACKGROUND: Right ventricular (RV) diastolic dysfunction precedes RV systolic dysfunction. Improvement in noninvasive assessment of RV diastolic function may enable earlier detection of RV dysfunction, especially important in the assessment of patients with congenital heart disease. We investigated a new parameter we call RV end-diastolic wall stress (RVEDWS) in an effort to better characterize RV diastolic function. METHODS: We retrospectively studied consecutive adults with right-sided congenital heart disease between January 2005 and November 2006...
July 2013: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/22744937/assessment-of-echocardiography-and-biomarkers-for-the-extended-prediction-of-cardiotoxicity-in-patients-treated-with-anthracyclines-taxanes-and-trastuzumab
#17
MULTICENTER STUDY
Heloisa Sawaya, Igal A Sebag, Juan Carlos Plana, James L Januzzi, Bonnie Ky, Timothy C Tan, Victor Cohen, Jose Banchs, Joseph R Carver, Susan E Wiegers, Randolph P Martin, Michael H Picard, Robert E Gerszten, Elkan F Halpern, Jonathan Passeri, Irene Kuter, Marielle Scherrer-Crosbie
BACKGROUND: Because cancer patients survive longer, the impact of cardiotoxicity associated with the use of cancer treatments escalates. The present study investigates whether early alterations of myocardial strain and blood biomarkers predict incident cardiotoxicity in patients with breast cancer during treatment with anthracyclines, taxanes, and trastuzumab. METHODS AND RESULTS: Eighty-one women with newly diagnosed human epidermal growth factor receptor 2-positive breast cancer, treated with anthracyclines followed by taxanes and trastuzumab were enrolled to be evaluated every 3 months during their cancer therapy (total of 15 months) using echocardiograms and blood samples...
September 1, 2012: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/22447943/cardiac-response-to-doxorubicin-and-dexrazoxane-in-intact-and-ovariectomized-young-female-rats-at-rest-and-after-swim-training
#18
COMPARATIVE STUDY
Annie Calvé, Rami Haddad, Sarah-Neiel Barama, Melissa Meilleur, Igal A Sebag, Lorraine E Chalifour
The impact of cancer therapies on adult cardiac function is becoming a concern as more children survive their initial cancer. Cardiovascular disease is now a significant problem to adult survivors of childhood cancer. Specifically, doxorubicin (DOX) may be particularly harmful in young girls. The objective of this study was to characterize DOX damage and determine the ability of dexrazoxane (DEX) to reduce DOX-mediated cardiac damage in sedentary and swim-trained female rats. Female Sprague-Dawley rats were left intact or ovariectomized (OVX) at weaning then injected with DEX (60 mg/kg) before DOX (3 mg/kg), DOX alone, or PBS...
May 15, 2012: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/21803942/sex-hormone-control-of-left-ventricular-structure-function-mechanistic-insights-using-echocardiography-expression-and-dna-methylation-analyses-in-adult-mice
#19
Igal A Sebag, Marc-Antoine Gillis, Angelino Calderone, Amanda Kasneci, Melissa Meilleur, Rami Haddad, William Noiles, Bhavini Patel, Lorraine E Chalifour
Calcium flux into and out of the sarco(endo)plasmic reticulum is vitally important to cardiac function because the cycle of calcium entry and exit controls contraction and relaxation. Putative estrogen and androgen consensus binding sites near to a CpG island are present in the cardiac calsequestrin 2 (CSQ2) promoter. Cardiomyocytes express sex hormone receptors and respond to sex hormones. We hypothesized that sex hormones control CSQ2 expression in cardiomyocytes and so affect cardiac structure/function. Echocardiographic analysis of male and female C57bl6n mice identified thinner walled and lighter hearts in females and significant concentric remodeling after long-term gonadectomy...
October 2011: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/21482175/unsupervised-dealiasing-and-denoising-of-color-doppler-data
#20
Stéphan Muth, Sarah Dort, Igal A Sebag, Marie-Josée Blais, Damien Garcia
Color Doppler imaging (CDI) is the premiere modality to analyze blood flow in clinical practice. In the prospect of producing new CDI-based tools, we developed a fast unsupervised denoiser and dealiaser (DeAN) algorithm for color Doppler raw data. The proposed technique uses robust and automated image post-processing techniques that make the DeAN clinically compliant. The DeAN includes three consecutive advanced and hands-off numerical tools: (1) statistical region merging segmentation, (2) recursive dealiasing process, and (3) regularized robust smoothing...
August 2011: Medical Image Analysis
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