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JOURNAL ARTICLE
Mario Henríquez-Beltrán, Rafaela Vaca, Iván D Benítez, Jessica González, Sally Santisteve, Maria Aguilà, Olga Minguez, Anna Moncusí-Moix, Clara Gort-Paniello, Gerard Torres, Gonzalo Labarca, Jesús Caballero, Carme Barberà, Antoni Torres, David de Gonzalo-Calvo, Ferran Barbé, Adriano D S Targa
OBJECTIVES: To investigate the sleep and circadian health of critical survivors 12 months after hospital discharge and to evaluate a possible effect of the severity of the disease within this context. DESIGN: Observational, prospective study. SETTING: Single-center study. PATIENTS: Two hundred sixty patients admitted to the ICU due to severe acute respiratory syndrome coronavirus 2 infection. INTERVENTIONS: None...
April 10, 2024: Critical Care Medicine
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JOURNAL ARTICLE
Marcos Moreno-Aguilera, Alba M Neher, Mónica B Mendoza, Martin Dodel, Faraz K Mardakheh, Raúl Ortiz, Carme Gallego
Alternative RNA splicing is an essential and dynamic process in neuronal differentiation and synapse maturation, and dysregulation of this process has been associated with neurodegenerative diseases. Recent studies have revealed the importance of RNA-binding proteins in the regulation of neuronal splicing programs. However, the molecular mechanisms involved in the control of these splicing regulators are still unclear. Here we show that KIS, a kinase upregulated in the developmental brain, imposes a genome-wide alteration in exon usage during neuronal differentiation in mice...
April 10, 2024: ELife
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JOURNAL ARTICLE
Carme Merced, Laia Pratcorona, Teresa Higueras, Mireia Vargas, Esther Del Barco, Judit Solà, Elena Carreras, Maria Goya
INTRODUCTION: We aimed to identify the incidence and risk factors of spontaneous preterm birth in pessary carriers with singleton pregnancies and a short cervix in the mid-trimester of pregnancy. MATERIAL AND METHODS: Patient data were obtained from the PECEP Trial. We analyzed singleton pregnancies in pessary carriers with a short cervix (≤25 mm) between 18 and 22 gestational weeks. Demographics and obstetric history were compared to identify risk factors for spontaneous preterm birth < 34 gestational weeks...
June 2024: European journal of obstetrics & gynecology and reproductive biology: X
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JOURNAL ARTICLE
Samantha Schiller, Idan Carmeli, Ran Orgad, Hanoch Kashtan, Lisa Cooper, Daniel Solomon
Current management of esophageal carcinoma (EC) involves combining different modalities, offering the opportunity of personalized strategies. This is particularly enticing in the geriatric population, where tailoring treatment modalities remains key to achieve good outcomes in terms of both quality of life and survival. Primary outcomes of our review included (1) evidence on short-term outcomes following esophagectomy, and (2) evidence on long-term outcomes following esophagectomy. Secondary review questions compared outcomes of (1) neoadjuvant treatment versus upfront surgery for locally advanced esophageal carcinoma, (2) endoscopic submucosal dissection versus esophagectomy for early esophageal carcinoma, and (3) definitive radiation with or without chemotherapy versus surgery...
April 8, 2024: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
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JOURNAL ARTICLE
Silvia Barro Lugo, Clara Flamarich Gol, M Ángeles González Martínez, Ángela Sampedro Elvira, Carme Saperas Pérez, Consuelo Sánchez Collado
The care of migrant patients includes initial screening and lifelong monitoring, highlighting the importance of preventing and tracking chronic, communicable and non-communicable diseases. The prevalence of hypertension, diabetes mellitus, dyslipidemia, and obesity varies by ethnicity, influenced by genetic factors, lifestyle, and socio-economic status. Preventive measures, health promotion, and risk factor identification are crucial. Chronic communicable diseases may manifest years after transmission, underscoring the necessity of primary care screening, especially for populations from endemic or high-risk areas...
April 6, 2024: Atencion Primaria
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JOURNAL ARTICLE
Vicente Merino-Bohórquez, Silvia Berisa-Prado, Mercedes Delgado-Valverde, María José Tirado-Pérez, Marta García-Palomo, José María Alonso-Herreros, Carme Cañete-Ramírez, María Del Dávila-Pousa
OBJECTIVE: To study the physicochemical and microbiological stability over 90 days of two preservative-free methylprednisolone sodium succinate (MTPSS) 1 mg/ml and 10 mg/ml eye drops for use in ocular pathologies such as Sjögren's syndrome and dry eye syndrome. METHOD: The two eye drops were prepared from injectable MTPSS (Solu-moderin® and Urbason®), water for injection and normal saline solution. In accordance with ICH (International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use) guidelines, they were then stored in triplicate under refrigerated conditions (5 ±3 °C), at room temperature (25 ± 2 °C), and at 40 °C (±2 °C)...
April 2, 2024: Farmacia Hospitalaria
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REVIEW
Cornelia Wagner, Cristian Carmeli, Josephine Jackisch, Mika Kivimäki, Bernadette W A van der Linden, Stéphane Cullati, Arnaud Chiolero
Life course epidemiology aims to study the effect of exposures on health outcomes across the life course from a social, behavioural, and biological perspective. In this Review, we describe how life course epidemiology changes the way the causes of chronic diseases are understood, with the example of hypertension, breast cancer, and dementia, and how it guides prevention strategies. Life course epidemiology uses complex methods for the analysis of longitudinal, ideally population-based, observational data and takes advantage of new approaches for causal inference...
April 2024: Lancet. Public Health
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JOURNAL ARTICLE
Pere Godoy, Iván Martínez-Baz, Ignasi Parron, Manuel García-Cenoz, Joaquim Ferras, Mònica Carol, Nuria Bes, Montserrat Guillaumes, Sofia Godoy, Diana Toledo, Núria Follia, Carme Miret, Jessica Pardos, Miquel Alsedà, Pedro Plans-Rubio, Inma Sanz, Maria-Rosa Sala, Joan A Caylà, Jacobo Mendioroz, Carmen Muñoz-Almagro, Jesús Castilla, Ángela Domínguez, On Behalf Of The Sars-CoV-Transmission To Household Contacts Working Group
The aim of this study was to evaluate the impact of index case vaccination on SARS-CoV-2 transmission to household contacts. In our epidemiological cohort study (May 2022-November 2023), we surveyed registered index case vaccination status and test results for contacts (testing on day 0, and on day 7 for negative contacts) and calculated the secondary attack rate (SAR), i.e., newly infected contacts/susceptible included contacts. The association of the independent variable, index case COVID-19 vaccination (yes/no), with household contact infection was determined using the adjusted odds ratio (aOR) and its 95% confidence interval (CI)...
February 26, 2024: Vaccines
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JOURNAL ARTICLE
Neus I Berenguer, Vicente J Sifre Canet, Carme Soler Canet, Sergi Segarra, Alejandra García de Carellán, C Iván Serra Aguado
Osteoarthritis (OA) is a pathology of great impact worldwide. Its physiopathology is not completely known, and it is usually diagnosed by imaging techniques performed at advanced stages of the disease. The aim of this study was to evaluate early serum metabolome changes and identify the main metabolites involved in an inflammatory OA animal model. This study was performed on thirty rats. OA was induced in all animals by intra-articular injection of monoiodoacetate into the knee joint. Blood samples were taken from all animals and analyzed by mass spectrometry before OA induction and 28, 56, and 84 days following induction...
March 9, 2024: International Journal of Molecular Sciences
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JOURNAL ARTICLE
Cesar Jessé Enríquez-Rodríguez, Carme Casadevall, Rosa Faner, Ady Castro-Costa, Sergi Pascual-Guàrdia, Luis Seijó, José Luis López-Campos, Germán Peces-Barba, Eduard Monsó, Esther Barreiro, Borja G Cosío, Alvar Agustí, Joaquim Gea
BACKGROUND: Some patients with COPD suffer frequent exacerbations (FE). We hypothesised that their systemic proteomic profile would be different from that of non-frequent exacerbators (NFE). The objective of the present study was to contrast the systemic proteomic profile in FE versus NFE. As a reference, we also determined the systemic proteomic profile of healthy controls (HC) and COPD patients during an actual episode of exacerbation (AE). METHODS: In the analysis we included 40 clinically stable COPD patients (20 FE and 20 NFE), and 20 HC and 10 AE patients...
March 2024: ERJ Open Research
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REVIEW
Tuominen Leena, Poraharju Jenna, Carrion Carme, Lehtiö Leeni, Leino-Kilpi Helena, Moretó Sònia, Stolt Minna, Sulosaari Virpi, Virtanen Heli
BACKGROUND: The digital transformation of healthcare enables new ways of working in cancer care directing attention on the digital skills of healthcare professionals. This systematic review aims to identify existing evidence about digital skills among health care professionals in cancer care to identify the needs for future education and research. METHODS: Database searches were conducted in PubMed, CINAHL, Web of Science, Scopus, Cochrane and ERIC to identify studies until March 2023...
2024: Digital Health
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JOURNAL ARTICLE
Mostafa Bondok, Mohamed S Bondok, Christine Law, Nawaaz Nathoo, Karim F Damji
BACKGROUND: Applicants to ophthalmology have high rates of going unmatched during the CaRMS process, but how this compares to other competitive or surgical specialties remains unclear. Our research aims to examine this phenomenon by identifying trends and comparing match data with other specialties, to identify disparities that may inform the need for future interventions to improve the match process for applicants. METHODS: We used a cross-sectional analysis of data provided by CaRMS on the residency match from 2013 to 2022...
February 2024: Canadian Medical Education Journal
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JOURNAL ARTICLE
Javier Oltra, Barbara Segura, Antonio P Strafella, Thilo van Eimeren, Naroa Ibarretxe-Bilbao, Maria Diez-Cirarda, Carsten Eggers, Olaia Lucas-Jiménez, Gemma C Monté-Rubio, Natalia Ojeda, Javier Peña, Marina C Ruppert, Roser Sala-Llonch, Hendrik Theis, Carme Uribe, Carme Junque
Clinical, cognitive, and atrophy characteristics depending on sex have been previously reported in Parkinson's disease (PD). However, though sex differences in cortical gray matter measures in early drug naïve patients have been described, little is known about differences in cortical thickness (CTh) as the disease advances. Our multi-site sample comprised 211 non-demented PD patients (64.45% males; mean age 65.58 ± 8.44 years old; mean disease duration 6.42 ± 5.11 years) and 86 healthy controls (50% males; mean age 65...
March 23, 2024: NPJ Parkinson's Disease
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JOURNAL ARTICLE
Marta Puerto, Mamta Shukla, Paula Bujosa, Juan Pérez-Roldán, Mònica Torràs-Llort, Srividya Tamirisa, Albert Carbonell, Carme Solé, Joynob Akter Puspo, Christopher T Cummings, Eulàlia de Nadal, Francesc Posas, Fernando Azorín, M Jordan Rowley
Chromosome pairing constitutes an important level of genome organization, yet the mechanisms that regulate pairing in somatic cells and the impact on 3D chromatin organization are still poorly understood. Here, we address these questions in Drosophila, an organism with robust somatic pairing. In Drosophila, pairing preferentially occurs at loci consisting of numerous architectural protein binding sites (APBSs), suggesting a role of architectural proteins (APs) in pairing regulation. Amongst these, the anti-pairing function of the condensin II subunit CAP-H2 is well established...
March 23, 2024: Nucleic Acids Research
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JOURNAL ARTICLE
Arsida Bajrami, Serdar Geyik, Ozgur Ertugrul, Eren Erdem, Jose I Gallego Leon, Giorgio Barbieri, Carlos Dominguez Rodriguez, Jose Carlos Rayón-Aledo, Antonio I Sagredo Barra, Fernando S Sanchez Blanco, Carmen Serna Candel, Francisco Jose Montalverne, Lidemarcks I Andrade, Diego Bandeira, Jose Bezerra, Hellen Carm, Henrique Coelho Silva, Alessandra Braga Cruz Guedes de Morais, Adson Freitas de Lucena, Fabricio O Lima, George Mendes, Felipe A Rocha, Karlis Kupcs, Helmuts Kidikas, Janis Vetra, Gyula Gal, Anabel Diaz, Raul G Nogueira
BACKGROUND: The best strategy to achieve optimal reperfusion outcomes during mechanical thrombectomy remains to be defined. The RapidPulseTM Cyclic Aspiration System is a novel technology, delivering high-frequency pulsed vacuum forces to increase the efficiency of aspiration thrombectomy. METHODS: Prospective, multicenter, open-label, core lab-adjudicated, two-arm study comparing safety and efficacy of a feasibility version of the RapidPulseTM system compared with contemporary controls...
March 22, 2024: Interventional Neuroradiology
#36
MULTICENTER STUDY
Adrian Ceccato, Carles Forne, Lieuwe D Bos, Marta Camprubí-Rimblas, Aina Areny-Balagueró, Elena Campaña-Duel, Sara Quero, Emili Diaz, Oriol Roca, David De Gonzalo-Calvo, Laia Fernández-Barat, Anna Motos, Ricard Ferrer, Jordi Riera, Jose A Lorente, Oscar Peñuelas, Rosario Menendez, Rosario Amaya-Villar, José M Añón, Ana Balan-Mariño, Carme Barberà, José Barberán, Aaron Blandino-Ortiz, Maria Victoria Boado, Elena Bustamante-Munguira, Jesús Caballero, Cristina Carbajales, Nieves Carbonell, Mercedes Catalán-González, Nieves Franco, Cristóbal Galbán, Víctor D Gumucio-Sanguino, Maria Del Carmen de la Torre, Ángel Estella, Elena Gallego, José Luis García-Garmendia, José Garnacho-Montero, José M Gómez, Arturo Huerta, Ruth Noemí Jorge-García, Ana Loza-Vázquez, Judith Marin-Corral, Amalia Martínez de la Gándara, María Cruz Martin-Delgado, Ignacio Martínez-Varela, Juan Lopez Messa, Guillermo Muñiz-Albaiceta, María Teresa Nieto, Mariana Andrea Novo, Yhivian Peñasco, Juan Carlos Pozo-Laderas, Felipe Pérez-García, Pilar Ricart, Ferran Roche-Campo, Alejandro Rodríguez, Victor Sagredo, Angel Sánchez-Miralles, Susana Sancho-Chinesta, Lorenzo Socias, Jordi Solé-Violan, Fernando Suarez-Sipmann, Luis Tamayo-Lomas, José Trenado, Alejandro Úbeda, Luis Jorge Valdivia, Pablo Vidal, Jesus Bermejo, Jesica Gonzalez, Ferran Barbe, Carolyn S Calfee, Antonio Artigas, Antoni Torres
BACKGROUND: Acute respiratory distress syndrome (ARDS) can be classified into sub-phenotypes according to different inflammatory/clinical status. Prognostic enrichment was achieved by grouping patients into hypoinflammatory or hyperinflammatory sub-phenotypes, even though the time of analysis may change the classification according to treatment response or disease evolution. We aimed to evaluate when patients can be clustered in more than 1 group, and how they may change the clustering of patients using data of baseline or day 3, and the prognosis of patients according to their evolution by changing or not the cluster...
March 21, 2024: Critical Care: the Official Journal of the Critical Care Forum
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JOURNAL ARTICLE
Guillermo Z Martínez-Pérez, Carme Campoy Guerrero, Brigitte Bagnol, Samba Cor Sarr, El Hadji Mamadou Mbaye, Ousmane Diouf, El Hadji Ibrahima Touré, Viviane Mbengue, Oumy Ndiaye, Farah Nabil
Health research must be of high ethical and scientific quality and consider the needs and experiences of women, men, and nonbinary individuals. National Research Ethics Committees (RECs) are in a strategic position to impede sex- and gender-blind research. In 2020 and 2021, training programs on gender mainstreaming and sex and gender approaches in research evaluation were launched in Senegal. They were evaluated through a mixture of qualitative and quantitative methods. Knowledge acquisition was 16.67%, 8.54%, and 28...
March 18, 2024: Journal of Empirical Research on Human Research Ethics: JERHRE
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JOURNAL ARTICLE
Shlomo Guzmen-Carmeli, Rotem Weizman, Tammar Friedman
This essay deals with perceptions of smoking among Haredi men in Israel. Though trends in smoking within the Haredi society have been quantitively examined, no qualitative research has ever focused on the motivations and mindsets stimulating individuals' choices to take health risks despite religious precepts to the contrary. Israeli Haredi men sometimes start smoking in their early childhood and are unmotivated to quit, and such circumstances should be examined. We interviewed 20 Israeli Haredi male smokers and overviewed the Haredi daily press and rabbinical attitudes toward smoking...
March 15, 2024: Journal of Religion and Health
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JOURNAL ARTICLE
Cristina Nogueroles Blanco, Sara Fuentes Carretero, Carme Grande Moreillo, Jaume Margarit Mallol
No abstract text is available yet for this article.
March 14, 2024: Anales de pediatría
#40
REVIEW
Montserrat Compa, Xavier Capó, Carme Alomar, Salud Deudero, Antoni Sureda
Over the past decade, global reports have shown a rise in the harmful effects of microplastics (MPs) on marine fish. This study analysed marine species' biochemical biomarker responses to microplastic exposure, finding that MPs can induce oxidative stress in marine fish through meta-regression results. Overall, exposure to MPs resulted in the activation of antioxidant defence mechanisms, such as superoxide dismutase, catalase and glutathione reductase, detoxification enzymes such as glutathione-S-transferase, the detection of malondialdehyde, and inhibition of acetylcholinesterase...
March 12, 2024: Environmental Toxicology and Pharmacology
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