keyword
https://read.qxmd.com/read/38403881/the-rise-of-single-cell-transcriptomics-in-yeast
#21
REVIEW
Mariona Nadal-Ribelles, Carme Solé, Eulalia de Nadal, Francesc Posas
The field of single-cell omics has transformed our understanding of biological processes and is constantly advancing both experimentally and computationally. One of the most significant developments is the ability to measure the transcriptome of individual cells by single-cell RNA-seq (scRNA-seq), which was pioneered in higher eukaryotes. While yeast has served as a powerful model organism in which to test and develop transcriptomic technologies, the implementation of scRNA-seq has been significantly delayed in this organism, mainly because of technical constraints associated with its intrinsic characteristics, namely the presence of a cell wall, a small cell size and little amounts of RNA...
February 25, 2024: Yeast
https://read.qxmd.com/read/38402026/lysyl-oxidase-expression-in-smooth-muscle-cells-determines-the-level-of-intima-calcification-in-hypercholesterolemia-induced-atherosclerosis
#22
JOURNAL ARTICLE
Carme Ballester-Servera, Judith Alonso, Manel Taurón, Noemí Rotllán, Cristina Rodríguez, José Martínez-González
INTRODUCTION: Cardiovascular calcification is an important public health issue with an unmeet therapeutic need. We had previously shown that lysyl oxidase (LOX) activity critically influences vascular wall smooth muscle cells (VSMCs) and valvular interstitial cells (VICs) calcification by affecting extracellular matrix remodeling. We have delved into the participation of LOX in atherosclerosis and vascular calcification, as well as in the mineralization of the aortic valve. METHODS: Immunohistochemical and expression studies were carried out in human atherosclerotic lesions and experimental models, valves from patients with aortic stenosis, VICs, and in a genetically modified mouse model that overexpresses LOX in CMLV (TgLOXCMLV )...
February 23, 2024: Clínica e Investigación en Arteriosclerosis
https://read.qxmd.com/read/38400943/effects-of-preoperative-quadruple-therapy-for-helicobacter-pylori-on-bariatric-surgery-metabolic-outcomes
#23
JOURNAL ARTICLE
Albert Goday, Andrea Bagán, Anna Casajoana, Carme Serra, Manuel Pera, Montserrat Villatoro, Teresa Legido, Helena Julià, Elisenda Climent, Olga Castañer, Juana A Flores Le Roux, Miguel Olano, Juan Pedro-Botet, David Benaiges
PURPOSE: To assess the effects of Helicobacter pylori (HP) eradication with an omeprazole, clarithromycin, amoxicillin, and metronidazole (OCAM) regimen on the metabolic profile and weight loss 12 months after bariatric surgery (BS). METHODS: Retrospective analysis of a prospective cohort of patients with morbid obesity undergoing BS. HP presence was tested preoperatively by gastric biopsy and treated with OCAM when positive. Short-term metabolic outcomes and weight loss were evaluated...
February 24, 2024: Obesity Surgery
https://read.qxmd.com/read/38398469/new-designs-of-spectacle-lenses-for-the-control-of-myopia-progression-a-scoping-review
#24
REVIEW
Marta Lupon, Carme Nolla, Genis Cardona
Myopia control with new designs of spectacle lenses is a flourishing area of research. The present work reviews the effectiveness of new designs (DIMSs, defocus-incorporated multiple segments; CARE, cylindrical annular refractive element; HALs/SALs, highly/slightly aspherical lenslets; DOT, diffusion optics technology) aiming at slowing myopia progression. A search through the PubMed database was conducted for articles published between 1 January 2003 and 28 February 2023. Publications were included if they documented baseline central refraction (SER) and/or axial length (AL) data, and the change in these parameters, in myopic children wearing new designs of spectacle lenses (treatment group) compared to myopic children using single-vision lenses, SVLs (control group)...
February 19, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38398126/the-c250t-mutation-of-tertp-might-grant-a-better-prognosis-to-glioblastoma-by-exerting-less-biological-effect-on-telomeres-and-chromosomes-than-the-c228t-mutation
#25
JOURNAL ARTICLE
Teresa Gorria, Carme Crous, Estela Pineda, Ainhoa Hernandez, Marta Domenech, Carolina Sanz, Pedro Jares, Ana María Muñoz-Mármol, Oriol Arpí-Llucía, Bárbara Melendez, Marta Gut, Anna Esteve, Anna Esteve-Codina, Genis Parra, Francesc Alameda, Cristina Carrato, Iban Aldecoa, Mar Mallo, Nuria de la Iglesia, Carmen Balana
UNLABELLED: The aim of this study was to determine how TERTp mutations impact glioblastoma prognosis. MATERIALS AND METHODS: TERTp mutations were assessed in a retrospective cohort of 258 uniformly treated glioblastoma patients. RNA-sequencing and whole exome sequencing results were available in a subset of patients. RESULTS: Overall, there were no differences in outcomes between patients with mutated TERTp -wt or TERTp . However, we found significant differences according to the type of TERTp mutation...
February 9, 2024: Cancers
https://read.qxmd.com/read/38391499/the-yield-of-one-vs-two-blood-cultures-in-children-under-detection-and-over-testing
#26
JOURNAL ARTICLE
Anat Zalmanovich, Elizabeth Temkin, Dikla Biran, Yehuda Carmeli
We aimed to determine whether obtaining two blood cultures (BCs) instead of one improved the detection of bloodstream infections (BSIs) in children. For this descriptive study, we used surveillance data collected in 2019-2021 from all Israeli hospitals serving children. The sample included 178,702 culturing episodes. One BC was taken in 90.1% of all episodes and 98.2% of episodes in the emergency department. A true pathogen was detected in 1687/160,964 (1.0%) of single-culture episodes and 1567/17,738 (8.9%) of two-culture episodes ( p < 0...
January 23, 2024: Antibiotics
https://read.qxmd.com/read/38388110/effect-of-dairy-consumption-on-cognition-in-older-adults-a-population-based-cohort-study
#27
JOURNAL ARTICLE
Natalia Ortega, Cristian Carmeli, Orestis Efthimiou, Jürg-Hans Beer, Armin von Gunten, Martin Preisig, Leonardo Zullo, Julien Vaucher, Peter Vollenweider, Pedro Marques-Vidal, Nicolas Rodondi, Arnaud Chiolero, Patricia O Chocano-Bedoya
OBJECTIVE: We aimed to assess the effect on cognitive function of adding dairy (total, fermented, non-fermented, full fat, low fat, and sugary) to the diet and of substituting some food groups for dairy. DESIGN: Secondary analysis of a prospective population-based cohort study. PARTICIPANTS: We analyzed data from 1334 cognitively healthy participants (median age 67 years at baseline) with a mean follow-up of 5.6 years from the CoLaus|PsyColaus cohort in Lausanne, Switzerland...
February 2024: Journal of Nutrition, Health & Aging
https://read.qxmd.com/read/38383609/plant-trait-and-vegetation-data-along-a-1314%C3%A2-m-elevation-gradient-with-fire-history-in-puna-grasslands-per%C3%A3%C2%BA
#28
JOURNAL ARTICLE
Aud H Halbritter, Vigdis Vandvik, Sehoya H Cotner, William Farfan-Rios, Brian S Maitner, Sean T Michaletz, Imma Oliveras Menor, Richard J Telford, Adam Ccahuana, Rudi Cruz, Jhonatan Sallo-Bravo, Paul Efren Santos-Andrade, Lucely L Vilca-Bustamante, Matiss Castorena, Julia Chacón-Labella, Casper Tai Christiansen, Sandra M Duran, Dagmar D Egelkraut, Ragnhild Gya, Siri Vatsø Haugum, Lorah Seltzer, Miles R Silman, Tanya Strydom, Marcus P Spiegel, Agustina Barros, Kristine Birkeli, Mickey Boakye, Fernanda Chiappero, Adam Chmurzynski, Josef C Garen, Joseph Gaudard, Tasha-Leigh J Gauthier, Sonya R Geange, Fiorella N Gonzales, Jonathan J Henn, Kristýna Hošková, Anders Isaksen, Laura H Jessup, Will Johnson, Erik Kusch, Kai Lepley, Mackenzie Lift, Trace E Martyn, Miguel Muñoz Mazon, Sara L Middleton, Natalia L Quinteros Casaverde, Jocelyn Navarro, Verónica Zepeda, Korina Ocampo-Zuleta, Andrea Carmeli Palomino-Cardenas, Samuel Pastor Ploskonka, Maria Elisa Pierfederici, Verónica Pinelli, Jess Rickenback, Ruben E Roos, Hilde Stokland Rui, Eugenia Sanchez Diaz, Andrea Sánchez-Tapia, Alyssa Smith, Erickson Urquiaga-Flores, Jonathan von Oppen, Brian J Enquist
Alpine grassland vegetation supports globally important biodiversity and ecosystems that are increasingly threatened by climate warming and other environmental changes. Trait-based approaches can support understanding of vegetation responses to global change drivers and consequences for ecosystem functioning. In six sites along a 1314 m elevational gradient in Puna grasslands in the Peruvian Andes, we collected datasets on vascular plant composition, plant functional traits, biomass, ecosystem fluxes, and climate data over three years...
February 21, 2024: Scientific Data
https://read.qxmd.com/read/38382733/cities-and-mental-health-the-role-of-the-built-environment-and-environmental-and-lifestyle-factors-in-barcelona
#29
JOURNAL ARTICLE
Wilma Zijlema, Ester Cerin, Marta Cirach, Xavier Bartoll, Carme Borrell, Payam Dadvand, Mark J Nieuwenhuijsen
Built environment characteristics and related environmental exposures and behaviors have been, separately, implicated in the development of poor mental health. However, it is unclear how these factors act together in relation to mental health. We studied these factors simultaneously to evaluate the impact of the built environment, and the mediating role of environmental exposures and physical activity, on mental health, while also studying moderation by sex, age, and length of residence. We used a cross-sectional population-based sample of 3145 individuals aged 15-97 years from Barcelona, Spain...
February 19, 2024: Environmental Pollution
https://read.qxmd.com/read/38381609/assessing-viral-metagenomics-for-the-diagnosis-of-acute-undifferentiated-fever-in-returned-travellers-a-multicenter-cohort-study
#30
JOURNAL ARTICLE
Daniel Camprubí-Ferrer, Alexandru Tomazatos, Leire Balerdi-Sarasola, Ludovico G Cobuccio, Steven Van Den Broucke, Balázs Horváth, Marjan Van Esbroeck, Miguel J Martinez, Javier Gandasegui, Carme Subirà, Meritxell Saloni, Blaise Genton, Emmanuel Bottieau, Dániel Cadar, Jose Muñoz
BACKGROUND: Up to 45% of febrile returning travellers remain undiagnosed after a thorough diagnostic work-up, even at referral centers. Although metagenomic next-generation sequencing (mNGS) has emerged as a promising tool, evidence of its usefulness in imported fever is very limited. METHODS: Travellers returning with fever were prospectively recruited in three referral clinics from November 2017 to November 2019. Unbiased mNGS optimized for virus detection was performed on serum samples of participants with acute undifferentiated febrile illness (AUFI) and results were compared to those obtained by reference diagnostic methods (RDM)...
February 21, 2024: Journal of Travel Medicine
https://read.qxmd.com/read/38377712/-digital-literacy-as-a-key-element-in-the-digital-transformation-of-health-organizations
#31
JOURNAL ARTICLE
Iris Alarcón Belmonte, Rou Sánchez Collado, Oriol Yuguero, Jordi Acezat Oliva, Antonio Martínez-Millana, Carme Saperas Pérez
In the last years, the digital transformation, has become a reality influencing organizational processes and advancing services for users. This transformation must align with WHO guidelines, addressing the needs of individuals globally and acknowledging Social Determinants of Health and emerging Digital Determinants of Health and the digital divide thas has been created. To accomplish this, the appropriate legislation and infrastructures are required. Correspondingly technology enables enhanced self-care and increased participation in decision-making across various levels, consequently, addressing the digital divide must not be an exception, and needs to include citizens, communities, entities, and professionals to work on how to diminish it and solve it...
February 19, 2024: Atencion Primaria
https://read.qxmd.com/read/38374876/global-research-trends-on-cardiac-troponin-and-physical-activity-among-pediatric-populations-a-bibliometric-analysis-and-science-mapping-study
#32
JOURNAL ARTICLE
Vicenç Hernández-González, Enric Conesa-Milian, Carme Jové-Deltell, Álvaro Pano-Rodríguez, Alejandro Legaz-Arrese, Joaquin Reverter-Masia
BACKGROUND: Cardiac troponin (cTn) is a reliable marker for evaluating myocardial damage. cTn is a very specific protein involved in myocardial injury, and it is a key factor in the diagnosis of coronary syndromes. Bibliometric analysis was applied in the present work, with the main goal of evaluating global research on the topic of cardiac troponin in pediatric populations. METHODS: Publications about cardiac troponin and physical activity in pediatric populations were retrieved from the Social Sciences Citation Index (SSCI) and the Science Citation Index Expanded (SCIE) of the Web of Science Core Collection, and they were then analyzed...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38366375/lack-of-a-non-specific-protective-effect-of-prior-yellow-fever-vaccination-against-covid-19
#33
JOURNAL ARTICLE
Miguel Martínez-Lacalzada, Angeline Cruz, Carme Subirà, Isabel Vera, Montserrat Roldan, Teresa De Alba, Meritxell Saloni, Jose Muñoz, Natalia Rodríguez-Valero
No abstract text is available yet for this article.
February 15, 2024: Journal of Travel Medicine
https://read.qxmd.com/read/38361893/differences-between-international-medical-graduates-and-canadian-medical-graduates-in-a-medical-learning-environment-from-matching-to-residency-and-beyond
#34
JOURNAL ARTICLE
Oluwasayo A Olatunde
OBJECTIVE: To determine the differences between international medical graduates (IMG) and canadian medical graduates (CMG) in the medical learning environment (MLE) as there is progression from matching to residency and beyond. METHOD: A narrative literature review was done using the search engines pubmed, medline and embase on publications from 2000 to 2021 comparing IMG to CMG and those that compared IMG to non IMG in international publications were also considered...
December 2023: Journal of Family Medicine and Primary Care
https://read.qxmd.com/read/38361320/systemic-biomarker-associated-with-poor-outcome-after-futile-reperfusion
#35
JOURNAL ARTICLE
Pablo Hervella, Ana Sampedro-Viana, Manuel Rodríguez-Yáñez, Iria López-Dequidt, José M Pumar, Antonio J Mosqueira, Sabela Fernández-Rodicio, Marcos Bazarra-Barreiros, Joaquín Serena, Yolanda Silva-Blas, Carme Gubern-Merida, Daniel Rey-Aldana, Sergio Cinza, Francisco Campos, Tomás Sobrino, José Castillo, Maria Luz Alonso-Alonso, Ramón Iglesias-Rey
BACKGROUND: Successful recanalization does not lead to complete tissue reperfusion in a considerable percentage of ischemic stroke patients. This study aimed to identify biomarkers associated with futile recanalization. Leukoaraiosis predicts poor outcomes of this phenomenon. Soluble tumour necrosis factor-like weak inducer of apoptosis (sTWEAK), which is associated with leukoaraiosis degrees, could be a potential biomarker. METHODS: This study includes two cohorts of ischemic stroke patients in a multicentre retrospective observational study...
February 15, 2024: European Journal of Clinical Investigation
https://read.qxmd.com/read/38359818/microrna-guided-drug-discovery-for-mitigating-persistent-pulmonary-complications-in-critical-covid-19-survivors-a-longitudinal-pilot-study
#36
JOURNAL ARTICLE
María C García-Hidalgo, Iván D Benítez, Manel Perez-Pons, Marta Molinero, Thalía Belmonte, Carlos Rodríguez-Muñoz, María Aguilà, Sally Santisteve, Gerard Torres, Anna Moncusí-Moix, Clara Gort-Paniello, Rafael Peláez, Ignacio M Larráyoz, Jesús Caballero, Carme Barberà, Estefania Nova-Lamperti, Antoni Torres, Jessica González, Ferran Barbé, David de Gonzalo-Calvo
BACKGROUND AND PURPOSE: The post-acute sequelae of SARS-CoV-2 infection pose a significant global challenge, with nearly 50% of critical COVID-19 survivors manifesting persistent lung abnormalities. The lack of understanding about the molecular mechanisms and effective treatments hampers their management. Here, we employed microRNA (miRNA) profiling to decipher the systemic molecular underpinnings of the persistent pulmonary complications. EXPERIMENTAL APPROACH: We conducted a longitudinal investigation including 119 critical COVID-19 survivors...
February 15, 2024: British Journal of Pharmacology
https://read.qxmd.com/read/38351048/author-correction-molecular-basis-for-bacterial-n-glycosylation-by-a-soluble-hmw1c-like-n-glycosyltransferase
#37
Beatriz Piniello, Javier Macías-León, Shun Miyazaki, Ana García-García, Ismael Compañón, Mattia Ghirardello, Víctor Taleb, Billy Veloz, Francisco Corzana, Atsushi Miyagawa, Carme Rovira, Ramon Hurtado-Guerrero
No abstract text is available yet for this article.
February 13, 2024: Nature Communications
https://read.qxmd.com/read/38335967/identification-of-differential-biological-activity-and-synergy-between-the-parp-inhibitor-rucaparib-and-its-major-metabolite
#38
JOURNAL ARTICLE
Huabin Hu, Carme Serra, Wenjie Zhang, Aurora Scrivo, Irene Fernández-Carasa, Antonella Consiglio, Alvaro Aytes, Miguel Angel Pujana, Amadeu Llebaria, Albert A Antolin
The (poly)pharmacology of drug metabolites is seldom comprehensively characterized in drug discovery. However, some drug metabolites can reach high plasma concentrations and display in vivo activity. Here, we use computational and experimental methods to comprehensively characterize the kinase polypharmacology of M324, the major metabolite of the PARP1 inhibitor rucaparib. We demonstrate that M324 displays unique PLK2 inhibition at clinical concentrations. This kinase activity could have implications for the efficacy and safety of rucaparib and therefore warrants further clinical investigation...
February 6, 2024: Cell Chemical Biology
https://read.qxmd.com/read/38331297/plastic-webs-the-new-food-dynamics-of-microplastics-in-a-mediterranean-food-web-key-species-as-pollution-sources-and-receptors
#39
JOURNAL ARTICLE
Ruben Olmo-Gilabert, Valentina Fagiano, Carme Alomar, Beatriz Rios-Fuster, Montserrat Compa, Salud Deudero
In the context of global environmental change, this study presents a novel approach to evaluating microplastic (MP) fluxes and probabilities of pollution within marine food webs. A topological model was built to understand the dynamics of MP pollution in the Mediterranean food webs. The analysis involves two approaches: the first approach includes centrality measures to understand the key role of species in the transmission of trophic effects regarding MPs, and the second approach incorporates MP data by developing the Interaction Pollution Indices (IPIs) at multiple levels to identify species being sources and receptors of MP pollution in the new concept of a plastic-food web...
February 6, 2024: Science of the Total Environment
https://read.qxmd.com/read/38323791/a-pipeline-for-rapidly-evaluating-activity-and-inferring-mechanisms-of-action-of-prospective-antifungal-compounds
#40
JOURNAL ARTICLE
Judith Kraut-Cohen, Omer Frenkel, Shay Covo, Evgeniya Marcos-Hadad, Shmuel Carmeli, Eduard Belausov, Dror Minz, Eddie Cytryn
BACKGROUND: Fungal phytopathogens are a significant threat to crops and food security, and there is a constant need to develop safe and effective compounds that antagonize them. In-planta assays are complex and tedious and are thus not suitable for initial high-throughput screening of new candidate antifungal compounds. We propose an in vitro screening pipeline that integrates five rapid quantitative and qualitative methods to estimate the efficacy and mode of action of prospective antifungal compounds...
February 7, 2024: Pest Management Science
keyword
keyword
20932
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.