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https://www.readbyqxmd.com/read/29775592/dietary-and-microbial-oxazoles-induce-intestinal-inflammation-by-modulating-aryl-hydrocarbon-receptor-responses
#1
Shankar S Iyer, Thomas Gensollen, Amit Gandhi, Sungwhan F Oh, Joana F Neves, Frederic Collin, Richard Lavin, Carme Serra, Jonathan Glickman, Punyanganie S A de Silva, R Balfour Sartor, Gurdyal Besra, Russell Hauser, Anthony Maxwell, Amadeu Llebaria, Richard S Blumberg
Genome-wide association studies have identified risk loci associated with the development of inflammatory bowel disease, while epidemiological studies have emphasized that pathogenesis likely involves host interactions with environmental elements whose source and structure need to be defined. Here, we identify a class of compounds derived from dietary, microbial, and industrial sources that are characterized by the presence of a five-membered oxazole ring and induce CD1d-dependent intestinal inflammation. We observe that minimal oxazole structures modulate natural killer T cell-dependent inflammation by regulating lipid antigen presentation by CD1d on intestinal epithelial cells (IECs)...
May 17, 2018: Cell
https://www.readbyqxmd.com/read/29774265/assisted-reproduction-and-middle-east-kinship-a-regional-and-religious-comparison
#2
Marcia C Inhorn, Daphna Birenbaum-Carmeli, Soraya Tremayne, Zeynep B Gürtin
This article compares the use of assisted reproductive technology (ART) and resultant kinship formations in four Middle Eastern settings: the Sunni Muslim Arab world, the Sunni Muslim but officially 'secular' country of Turkey, Shia Muslim Iran and Jewish Israel. This four-way comparison reveals considerable similarities, as well as stark differences, in matters of Middle Eastern kinship and assisted reproduction. The permissions and restrictions on ART, often determined by religious decrees, may lead to counter-intuitive outcomes, many of which defy prevailing stereotypes about which parts of the Middle East are more 'progressive' or 'conservative'...
June 2017: Reproductive Biomedicine & Society Online
https://www.readbyqxmd.com/read/29771141/headache-comorbidities-and-lifestyle-in-an-adolescent-population-the-teens-study
#3
Marta Torres-Ferrus, Carme Vila-Sala, Manuel Quintana, Sara Ajanovic, Victor José Gallardo, Juan Bernardo Gomez, José Alvarez-Sabin, Alfons Macaya, Patricia Pozo-Rosich
Objective To evaluate the prevalence and characteristics of headache and its relationship with comorbidities and lifestyle in a teenage population. Methods This is a cross-sectional study. Data was collected from students aged 12-18 years from six different schools in Catalonia, Spain. They completed an anonymous questionnaire with demographic, lifestyle, medical data, presence of recurrent headaches and its features, and completed the Strengths and Difficulties Questionnaire. We defined probable migraine if headache presented ≥ 3 ICHD-3 beta criteria for migraine...
January 1, 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29761629/simultaneous-local-heating-thermometry-based-on-plasmonic-magnetochromic-nanoheaters
#4
Zhi Li, Alberto Lopez-Ortega, Antonio Aranda-Ramos, José Luis Tajada, Jordi Sort, Carme Nogues, Paolo Vavassori, Josep Nogues, Borja Sepulveda
A crucial challenge in nanotherapies is achieving accurate and real-time control of the therapeutic action, which is particularly relevant in local thermal therapies to minimize healthy tissue damage and necrotic cell deaths. Here, a nanoheater/thermometry concept is presented based on magnetoplasmonic (Co/Au or Fe/Au) nanodomes that merge exceptionally efficient plasmonic heating and simultaneous highly sensitive detection of the temperature variations. The temperature detection is based on precise optical monitoring of the magnetic-induced rotation of the nanodomes in solution...
May 14, 2018: Small
https://www.readbyqxmd.com/read/29758063/the-impact-of-antibiotic-use-on-transmission-of-resistant-bacteria-in-hospitals-insights-from-an-agent-based-model
#5
Jonatan Almagor, Elizabeth Temkin, Itzhak Benenson, Noga Fallach, Yehuda Carmeli
Extensive antibiotic use over the years has led to the emergence and spread of antibiotic resistant bacteria (ARB). Antibiotic resistance poses a major threat to public health since for many infections antibiotic treatment is no longer effective. Hospitals are focal points for ARB spread. Antibiotic use in hospitals exerts selective pressure, accelerating the spread of ARB. We used an agent-based model to explore the impact of antibiotics on the transmission dynamics and to examine the potential of stewardship interventions in limiting ARB spread in a hospital...
2018: PloS One
https://www.readbyqxmd.com/read/29752844/exploring-family-members-experiences-during-a-death-process-in-the-emergency-department-a-grounded-theory-study
#6
Carme Berbís-Morelló, Gerard Mora-López, Marta Berenguer-Poblet, Laia Raigal-Aran, Pilar Montesó-Curto, Carme Ferré-Grau
AIMS AND OBJECTIVES: To identify which are the needs arised from feelings, perceptions, and experiences of the family members during any time within the death process in an emergency service of an acute care hospital, with regards to the assistance received. BACKGROUND: The publications refer to the needs expressed by bereaved families, who explain the support they received right after the death of a relative in an emergency service, and during the months after the tragedy...
May 12, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29751214/a-study-of-the-properties-reactivity-and-anticancer-activity-of-novel-n-methylated-3-thiazolyl-or-3-thienyl-carbazoles-and-their-pd-ii-and-pt-ii-complexes
#7
Marta Reig, Ramón Bosque, Mercè Font-Bardía, Carme Calvis, Ramon Messeguer, Laura Baldomà, Josefa Badía, Dolores Velasco, Concepción López
No abstract text is available yet for this article.
March 15, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29742424/inhibition-of-gsk3b-reduces-nfkb1-signaling-and-rescues-synaptic-activity-to-improve-the-rett-syndrome-phenotype-in-mecp2-knockout-mice
#8
Olga C Jorge-Torres, Karolina Szczesna, Laura Roa, Carme Casal, Louisa Gonzalez-Somermeyer, Marta Soler, Cecilia D Velasco, Pablo Martínez-San Segundo, Paolo Petazzi, Mauricio A Sáez, Raúl Delgado-Morales, Stephane Fourcade, Aurora Pujol, Dori Huertas, Artur Llobet, Sonia Guil, Manel Esteller
Rett syndrome (RTT) is the second leading cause of mental impairment in girls and is currently untreatable. RTT is caused, in more than 95% of cases, by loss-of-function mutations in the methyl CpG-binding protein 2 gene (MeCP2). We propose here a molecular target involved in RTT: the glycogen synthase kinase-3b (Gsk3b) pathway. Gsk3b activity is deregulated in Mecp2-knockout (KO) mice models, and SB216763, a specific inhibitor, is able to alleviate the clinical symptoms with consequences at the molecular and cellular levels...
May 8, 2018: Cell Reports
https://www.readbyqxmd.com/read/29727570/enhanced-particle-swarm-optimization-algorithm-efficient-training-of-reaxff-reactive-force-fields
#9
David Furman, Benny Carmeli, Yehuda Zeiri, Ronnie Kosloff
Particle swarm optimization is a powerful metaheuristic population-based global optimization algorithm. However, when applied to non-separable objective functions its performance on multimodal landscapes is significantly degraded. Here we show that a significant improvement in the search quality and efficiency on multimodal functions can be achieved by enhancing the basic rotation-invariant particle swarm optimization algorithm with isotropic Gaussian mutation operators. The new algorithm demonstrates a superior performance across several nonlinear, multimodal benchmark functions compared to the rotation-invariant Particle Swam Optimization (PSO) algorithm and the well-established simulated annealing and sequential one-parameter parabolic interpolation methods...
May 4, 2018: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29721207/impact-of-mutational-studies-on-the-diagnosis-and-the-outcome-of-high-risk-myelodysplastic-syndromes-and-secondary-acute-myeloid-leukemia-patients-treated-with-5-azacytidine
#10
Marta Cabezón, Joan Bargay, Blanca Xicoy, Olga García, Josep Borrás, Mar Tormo, Sílvia Marcé, Carme Pedro, David Valcárcel, Maria-José Jiménez, Ramón Guàrdia, Laura Palomo, Salut Brunet, Ferran Vall-Llovera, Antoni Garcia, Evarist Feliu, Lurdes Zamora
Myelodysplastic syndromes (MDS) are stem cell disorders caused by various gene abnormalities. We performed targeted deep sequencing in 39 patients with high-risk MDS and secondary acute myeloid leukemia (sAML) at diagnosis and follow-up (response and/or relapse), with the aim to define their mutational status, to establish if specific mutations are biomarkers of response to 5-azacytidine (AZA) and/or may have impact on survival. Overall, 95% of patients harbored at least one mutation. TP53, DNMT3A and SRSF2 were the most frequently altered genes...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29718143/the-association-between-empirical-antibiotic-treatment-and-mortality-in-severe-infections-caused-by-carbapenem-resistant-gram-negative-bacteria-a-prospective-study
#11
Yael Zak-Doron, Yael Dishon Benattar, Iris Pfeffer, George L Daikos, Anna Skiada, Anastasia Antoniadou, Emanuele Durante-Mangoni, Roberto Andini, Giusi Cavezza, Leonard Leibovici, Dafna Yahav, Noa Elyakim-Raz, Yehuda Carmeli, Amir Nutman, Mical Paul
Background: Empirical colistin should be avoided. We aimed to evaluate the association between covering empirical antibiotics (EAT) and mortality for infections caused by carbapenem-resistant Gram-negative bacteria (CRGNB). Methods: Secondary analysis of a randomized-controlled trial, including adults with bloodstream infections (BSI), pneumonia or urosepsis caused by CRGNB. All patients received EAT followed by covering targeted therapy. The exposure variable was covering EAT in the first 48 hours...
April 27, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29715175/prognostic-implications-of-detectable-cardiac-troponin-i-below-the-99th-percentile-in-patients-admitted-to-an-emergency-department-without-acute-coronary-syndrome
#12
Alfredo Bardají, Gil Bonet, Anna Carrasquer, Maribel González-Del Hoyo, Fernando Domínguez, Rafael Sánchez, Carme Boqué, Germán Cediel
BACKGROUND: Detectable troponin below the 99th percentile may reflect an underlying cardiac abnormality which might entail prognostic consequences. This study aimed to investigate the prognosis of patients admitted to an emergency department (ED) with detectable troponin below the 99th percentile reference limit who did not present with an acute coronary syndrome (ACS). METHODS: We analysed the clinical data of all consecutive patients admitted to the ED during the years 2012 and 2013 in whom cardiac troponin was requested by the attending clinician (cTnI Ultra Siemens, Advia Centaur)...
May 1, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29714325/substrate-aberration-and-correction-for-meta-lens-imaging-an-analytical-approach
#13
Benedikt Groever, Charles Roques-Carmes, Steven J Byrnes, Federico Capasso
Meta-lenses based on flat optics enabled a fundamental shift in lens production-providing an easier manufacturing process with an increase in lens profile precision and a reduction in size and weight. Here we present an analytical approach to correct spherical aberrations caused by light propagation through the substrate by adding a substrate-corrected phase profile, which differs from the original hyperbolic one. A meta-lens encoding the new phase profile would yield diffraction-limited focusing and an increase of up to 0...
April 20, 2018: Applied Optics
https://www.readbyqxmd.com/read/29712879/low-levels-of-caveolin-1-predict-symptomatic-bleeding-after-thrombolytic-therapy-in-patients-with-acute-ischemic-stroke
#14
Mar Castellanos, Cecile van Eendenburg, Carme Gubern, Elisabet Kádár, Gemma Huguet, Josep Puig, Tomás Sobrino, Gerard Blasco, Joaquín Serena, Juan Manuel Sánchez
BACKGROUND AND PURPOSE: Experimental models of cerebral ischemia demonstrate that the decrease in the caveolin-1 membrane protein results in an increase in endothelial permeability. Because this phenomenon is responsible for hemorrhagic transformation (HT) after cerebral ischemia, we aimed to determine whether caveolin-1 levels may predict bleeding after recombinant tissue-type plasminogen activator (r-tPA) administration in patients with acute stroke. METHODS: We studied 133 patients with a first hemispheric stroke treated with r-tPA within 4...
April 30, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29704487/cervical-pessary-to-reduce-preterm-birth-before-34-weeks-of-gestation-after-an-episode-of-preterm-labor-and-a-short-cervix-a-randomized-controlled-trial
#15
Laia Pratcorona, Maria Goya, Carme Merced, Carlota Rodó, Elisa Llurba, Teresa Higueras, Luis Cabero, Elena Carreras
BACKGROUND: To date, no intervention has proved effective in reducing the spontaneous preterm birth rate in singleton pregnancies following an episode of threatened preterm labor and short cervix remaining. OBJECTIVE: This study was designed to ascertain whether cervical pessaries could be useful in preventing spontaneous preterm birth in women with singleton pregnancies and a short cervix after a threatened preterm labor episode. STUDY DESIGN: This open randomized controlled trial was conducted in 357 pregnant women (between 240 and 336 weeks) who had not delivered 48h after a threatened preterm labor episode and had a short cervix remaining (≤25 mm at 240 -296 weeks; ≤15mm at 300 -336 weeks)...
April 25, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29701488/effectiveness-of-a-dietary-supplement-containing-hydrolyzed-collagen-chondroitin-sulfate-and-glucosamine-in-pain-reduction-and-functional-capacity-in-osteoarthritis-patients
#16
Jordi Puigdellivol, Carme Comellas Berenger, Miguel Ángel Pérez Fernández, Juan M Cowalinsky Millán, Christian Carreras Vidal, Inés Gil Gil, Julio Martínez Pagán, Borja Ruiz Nieto, Francisco Jiménez Gómez, Francesc X Comas Figuerola, María E Aguilar Hernández
This observational, open, multicenter clinical trial with a single treatment group aimed to evaluate the effectiveness of a dietary supplement whose main ingredients are hydrolyzed gelatin, chondroitin sulfate, glucosamine sulfate, and devil's claw and bamboo extracts for pain reduction and improvement of functional capacities in patients with osteoarthritis (OA) of the knee and/or hip (REDART study). In all, 130 patients with OA recruited from Spanish hospitals received the dietary supplement for 6 months...
April 27, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29700105/lung-cancer-staging-a-concise-update
#17
Ramón Rami-Porta, Sergi Call, Christophe Dooms, Carme Obiols, Marcelo Sánchez, William D Travis, Ivan Vollmer
Diagnosis and clinical staging of lung cancer are fundamental to plan therapy. The techniques for clinical staging - anatomic and metabolic imaging, endoscopies and minimally invasive surgical procedures - should be performed sequentially and with an increasing degree of invasiveness. Intraoperative staging, assessing the magnitude of the primary tumour, the involved structures, and the loco-regional lymphatic spread by means of systematic nodal dissection, is essential to achieve a complete resection. In resected tumours, pathologic staging, with the systematic study of the resected specimens, is the strongest prognosticator and is essential to make further decisions on therapy...
April 26, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29695607/timing-of-gene-expression-in-a-cell-fate-decision-system
#18
Delphine Aymoz, Carme Solé, Jean-Jerrold Pierre, Marta Schmitt, Eulàlia de Nadal, Francesc Posas, Serge Pelet
During development, morphogens provide extracellular cues allowing cells to select a specific fate by inducing complex transcriptional programs. The mating pathway in budding yeast offers simplified settings to understand this process. Pheromone secreted by the mating partner triggers the activity of a MAPK pathway, which results in the expression of hundreds of genes. Using a dynamic expression reporter, we quantified the kinetics of gene expression in single cells upon exogenous pheromone stimulation and in the physiological context of mating...
April 25, 2018: Molecular Systems Biology
https://www.readbyqxmd.com/read/29695358/colistin-versus-colistin-plus-meropenem-for-severe-infections-authors-reply
#19
Mical Paul, Yehuda Carmeli, George L Daikos, Emanuele Durante-Mangoni, Ursula Theuretzbacher, Johan W Mouton, Leonard Leibovici
No abstract text is available yet for this article.
May 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29688744/reply-access-to-supplemental-oxygen-therapy-a-crisis
#20
Susan S Jacobs, Kathleen O Lindell, Eileen G Collins, Chris M Garvey, Carme Hernandez, Sally McLaughlin, Ann M Schneidman, Paula M Meek
No abstract text is available yet for this article.
April 24, 2018: Annals of the American Thoracic Society
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