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Albert Ariza-Solé, Carme Guerrero, Francesc Formiga, Jaime Aboal, Emad Abu-Assi, Francisco Marín, Héctor Bueno, Oriol Alegre, Ramón López-Palop, María T Vidán, Manuel Martínez-Sellés, Pablo Díez-Villanueva, Pau Vilardell, Alessandro Sionis, Miquel Vives-Borrás, Juan Sanchís, Jordi Bañeras, Agnès Rafecas, Cinta Llibre, Javier López, Violeta González-Salvado, Àngel Cequier
BACKGROUND:  Bleeding risk scores have shown a limited predictive ability in elderly patients with acute coronary syndromes (ACS). No study explored the role of a comprehensive geriatric assessment to predict in-hospital bleeding in this clinical setting. METHODS:  The prospective multicentre LONGEVO-SCA registry included 532 unselected patients with non-ST segment elevation ACS (NSTEACS) aged 80 years or older. Comorbidity (Charlson index), frailty (FRAIL scale), disability (Barthel index and Lawton-Brody index), cognitive status (Pfeiffer test) and nutritional risk (mini nutritional assessment-short form test) were assessed during hospitalization...
March 2018: Thrombosis and Haemostasis
Sharon Israely, Gerry Leisman, Chay C Machluf, Eli Carmeli
Purpose: A muscle synergies model was suggested to represent a simplifying motor control mechanism by the brainstem and spinal cord. The aim of the study was to investigate the feasibility of such control mechanisms in the rehabilitation of post-stroke individuals during the execution of hand-reaching movements in multiple directions, compared to non-stroke individuals. Methods: Twelve non-stroke and 13 post-stroke individuals participated in the study. Muscle synergies were extracted from EMG data that was recorded during hand reaching tasks, using the NMF algorithm...
2018: Frontiers in Computational Neuroscience
Lia Sousa, Carlos Sequeira, Carme Ferré-Grau
This article presents results from a conceptual validation of the programme 'Living Together with Dementia', through an e-Delphi study carried out during April/May, 2015 with 26 Portuguese and Spanish experts. The programme consists of seven individual weekly sessions and two group sessions over a seven-week period. It covers dementia, communication and behaviour; demands and expectations of the caregiver role; basic activities of daily living; coping and problem solving strategies; physical and mental health of the caregiver and community support...
January 1, 2018: Dementia
Emili Vela, Ákos Tényi, Isaac Cano, David Monterde, Montserrat Cleries, Anna Garcia-Altes, Carme Hernandez, Joan Escarrabill, Josep Roca
BACKGROUND: Clinical management of patients with chronic obstructive pulmonary disease (COPD) shows potential for improvement provided that patients' heterogeneities are better understood. The study addresses the impact of comorbidities and its role in health risk assessment. OBJECTIVE: To explore the potential of health registry information to enhance clinical risk assessment and stratification. DESIGN: Fixed cohort study including all registered patients with COPD in Catalonia (Spain) (7...
March 6, 2018: BMJ Open
Carme Martín-Borràs, Maria Giné-Garriga, Anna Puig-Ribera, Carlos Martín, Mercè Solà, Antonio I Cuesta-Vargas
INTRODUCTION: Studies had not yet overcome the most relevant barriers to physical activity (PA) adherence. An exercise referral scheme (ERS) with mechanisms to promote social support might enhance adherence to PA in the long term. SETTING: A randomised controlled trial in 10 primary care centres in Spain. OBJECTIVE: To assess the effectiveness of a primary care-based ERS linked to municipal resources and enhancing social support and social participation in establishing adherence to PA among adults over a 15-month period...
March 3, 2018: BMJ Open
Anat Lodin-Friedman, Shmuel Carmeli
During blooms, cyanobacteria produce diverse modified peptides. Among these are the microginins, which inhibit zinc-containing metalloproteases. Ten microginins, microginins KR767 ( 1 ), KR801( 2 ), KR835 ( 3 ), KR785 ( 4 ), KR604 ( 5 ), KR638 ( 6 ), KR781 ( 7 ), KR815 ( 8 ), FR3 ( 9 ), and FR4 ( 10 ), were isolated from the extract of a bloom material of Microcystis sp. (IL-405) collected from the Kishon Reservoir, Israel in the fall of 2009. The structures of the pure compounds were elucidated using 1D and 2D NMR techniques and high-resolution mass spectrometry...
March 2, 2018: Marine Drugs
Estefanía Moreno, Júlia Canet, Eduard Gracia, Carme Lluís, Josefa Mallol, Enric I Canela, Antoni Cortés, Vicent Casadó
Adenosine is an endogenous purine nucleoside that acts in all living systems as a homeostatic network regulator through many pathways, which are adenosine receptor (AR)-dependent and -independent. From a metabolic point of view, adenosine deaminase (ADA) is an essential protein in the regulation of the total intracellular and extracellular adenosine in a tissue. In addition to its cytosolic localization, ADA is also expressed as an ecto-enzyme on the surface of different cells. Dipeptidyl peptidase IV (CD26) and some ARs act as binding proteins for extracellular ADA in humans...
2018: Frontiers in Pharmacology
Rosa Rifà-Ros, Carme Espinosa Fresnedo, Mireia Alcázar París, Laia Raigal Aran, Carme Ferré Grau
OBJECTIVE: The objective of this article is to describe the developmental processes for the creation of the new diagnosis risk for complicated immigration transition for the NANDA-I. METHODS: The study followed the recommended steps of developmental processes for NANDA-I. The identification of risk factors,which cause those who have migrated to feel vulnerable, is the result of two different research studies aimed at identifying nursing diagnosis related to the immigration process...
February 27, 2018: International Journal of Nursing Knowledge
Gemma Navarro, Arnau Cordomí, Marc Brugarolas, Estefanía Moreno, David Aguinaga, Laura Pérez-Benito, Sergi Ferre, Antoni Cortés, Vicent Casadó, Josefa Mallol, Enric I Canela, Carme Lluís, Leonardo Pardo, Peter J McCormick, Rafael Franco
BACKGROUND: G-protein-coupled receptor (GPCR) heteromeric complexes have distinct properties from homomeric GPCRs, giving rise to new receptor functionalities. Adenosine receptors (A1 R or A2A R) can form A1 R-A2A R heteromers (A1 -A2A Het), and their activation leads to canonical G-protein-dependent (adenylate cyclase mediated) and -independent (β-arrestin mediated) signaling. Adenosine has different affinities for A1 R and A2A R, allowing the heteromeric receptor to detect its concentration by integrating the downstream Gi - and Gs -dependent signals...
February 28, 2018: BMC Biology
Gonzalo Crespo, Núria Trota, Maria-Carlota Londoño, Ezequiel Mauro, Carme Baliellas, Lluís Castells, Jose Castellote, Jaume Tort, Xavier Forns, Miquel Navasa
BACKGROUND AND AIMS: The efficacy of direct-acting antivirals (DAA) has dramatically changed the prognosis of patients with chronic hepatitis C. We aimed to evaluate the impact of DAA therapy in the composition of the liver transplant (LT) waiting list and the early post-transplant survival. METHODS: We evaluated all patients admitted in the waiting list for a primary LT between 1/1/2008 and 31/12/2016 in Catalonia, Spain. Time span was divided into two periods according to the availability of different antiviral therapies: 2008-2013 (IFN-based therapies) and 2014-2016 (DAA)...
February 23, 2018: Journal of Hepatology
Jan Gerrit van der Stouwe, Cristian Carmeli, Stefanie Aeschbacher, Tobias Schoen, Philipp Krisai, Giuditta Wenger, Georg Ehret, Belen Ponte, Menno Pruijm, Daniel Ackermann, Idris Guessous, Fred Paccaud, Antoinette Pechère-Bertschi, Bruno Vogt, Markus G Mohaupt, Pierre-Yves Martin, Michel Burnier, Martin Risch, Lorenz Risch, Murielle Bochud, David Conen
No abstract text is available yet for this article.
February 22, 2018: American Journal of Hypertension
Carme Rovira, Binju Wang, Ignacio Fita
Catalase-peroxidases (KatGs) are bifunctional enzymes exhibiting both peroxidase activities and substantial catalase activities as monofunctional catalases. It is widely recognized from experiments that the high catalatic activity of KatGs are correlated with the unique covalent adduct (M-Y-W) formed in the active site, but the exact role of this adduct is elusive up to now. Here, we employed quantum mechanical/molecular mechanical (QM/MM) calculations and QM/MM metadynamics to elucidate the molecular mechanism and the catalytic role of M-Y-W adduct in the catalase reaction...
February 20, 2018: Chemistry: a European Journal
Zhujun Shi, Mohammadreza Khorasaninejad, Yao-Wei Huang, Charles Roques-Carmes, Alexander Yutong Zhu, Wei Ting Chen, Vyshakh Sanjeev, Zhaowei Ding, Michele Tamagnone, Kundan Chaudhary, Robert Charles Devlin, Chengwei Qiu, Federico Capasso
In this paper, we report dispersion-engineered metasurfaces with distinct functionalities controlled by wavelength. Unlike previous approaches based on spatial multiplexing or vertical stacking of metasurfaces, we utilize a single phase profile with wavelength dependence encoded in the phase shifters' dispersion. We designed and fabricated a multiwavelength achromatic metalens (MAM) with achromatic focusing for blue (B), green (G), yellow (Y), and red (R) light; and two wavelength-controlled beam generators (WCBG): one focuses light with orbital angular momentum (OAM) states (l = 0,1,2) corresponding to three primary colors; the other produces ordinary focal spots (l = 0) for red and green light, while generating a vortex beam (l = 1) in the blue...
February 20, 2018: Nano Letters
Mical Paul, George L Daikos, Emanuele Durante-Mangoni, Dafna Yahav, Yehuda Carmeli, Yael Dishon Benattar, Anna Skiada, Roberto Andini, Noa Eliakim-Raz, Amir Nutman, Oren Zusman, Anastasia Antoniadou, Pia Clara Pafundi, Amos Adler, Yaakov Dickstein, Ioannis Pavleas, Rosa Zampino, Vered Daitch, Roni Bitterman, Hiba Zayyad, Fidi Koppel, Inbar Levi, Tanya Babich, Lena E Friberg, Johan W Mouton, Ursula Theuretzbacher, Leonard Leibovici
BACKGROUND: Colistin-carbapenem combinations are synergistic in vitro against carbapenem-resistant Gram-negative bacteria. We aimed to test whether combination therapy improves clinical outcomes for adults with infections caused by carbapenem-resistant or carbapenemase-producing Gram-negative bacteria. METHODS: A randomised controlled superiority trial was done in six hospitals in Israel, Greece, and Italy. We included adults with bacteraemia, ventilator-associated pneumonia, hospital-acquired pneumonia, or urosepsis caused by carbapenem-non-susceptible Gram-negative bacteria...
February 15, 2018: Lancet Infectious Diseases
Josep Ferrando, Laia Palència, Mercè Gotsens, Vanessa Puig-Barrachina, Marc Marí-Dell'Olmo, Maica Rodríguez-Sanz, Xavier Bartoll, Carme Borrell
OBJECTIVE: To determine if the onset of the economic crisis in Spain affected cancer mortality and mortality trends. METHOD: We conducted a longitudinal ecological study based on all cancer-related deaths and on specific types of cancer (lung, colon, breast and prostate) in Spain between 2000 and 2013. We computed age-standardised mortality rates in men and women, and fit mixed Poisson models to analyse the effect of the crisis on cancer mortality and trends therein...
February 13, 2018: Gaceta Sanitaria
Hugo C Baggio, Alexandra Abos, Barbara Segura, Anna Campabadal, Anna Garcia-Diaz, Carme Uribe, Yaroslau Compta, Maria Jose Marti, Francesc Valldeoriola, Carme Junque
The description of brain networks as graphs where nodes represent different brain regions and edges represent a measure of connectivity between a pair of nodes is an increasingly used approach in neuroimaging research. The development of powerful methods for edge-wise group-level statistical inference in brain graphs while controlling for multiple-testing associated false-positive rates, however, remains a difficult task. In this study, we use simulated data to assess the properties of threshold-free network-based statistics (TFNBS)...
February 15, 2018: Human Brain Mapping
Ankit Kapur
No abstract text is available yet for this article.
February 2018: Canadian Family Physician Médecin de Famille Canadien
Carme Uribe, Barbara Segura, Hugo Cesar Baggio, Alexandra Abos, Anna Isabel Garcia-Diaz, Anna Campabadal, Maria Jose Marti, Francesc Valldeoriola, Yaroslau Compta, Eduard Tolosa, Carme Junque
INTRODUCTION: Cortical brain atrophy detectable with MRI in non-demented advanced Parkinson's disease (PD) is well characterized, but its presence in early disease stages is still under debate. We aimed to investigate cortical atrophy patterns in a large sample of early untreated PD patients using a hypothesis-free data-driven approach. METHODS: Seventy-seven de novo PD patients and 50 controls from the Parkinson's Progression Marker Initiative database with T1-weighted images in a 3-tesla Siemens scanner were included in this study...
February 8, 2018: Parkinsonism & related Disorders
Jordi Olloquequi, Elizabeth Cornejo-Córdova, Ester Verdaguer, Francesc X Soriano, Octavio Binvignat, Carme Auladell, Antoni Camins
Neurological and psychiatric disorders are leading contributors to the global disease burden, having a serious impact on the quality of life of both patients and their relatives. Although the molecular events underlying these heterogeneous diseases remain poorly understood, some studies have raised the idea of common mechanisms involved. In excitotoxicity, there is an excessive activation of glutamate receptors by excitatory amino acids, leading to neuronal damage. Thus, the excessive release of glutamate can lead to a dysregulation of Ca 2+ homeostasis, triggering the production of free radicals and oxidative stress, mitochondrial dysfunction and eventually cell death...
February 1, 2018: Journal of Psychopharmacology
Raphael Henrique Déa Cirino, Rosana Herminia Scola, Renata Dal-Prá Ducci, Ana Cristina Camarozano Wermelinger, Claudia Suemi Kamoi Kay, Paulo José Lorenzoni, Lineu Cesar Werneck, Eliane Ribeiro Carmes, Claudio Leinig Pereira da Cunha
INTRODUCTION: Early detection of left ventricular systolic dysfunction (LVSD) is important for therapeutic strategies for Duchenne muscular dystrophy (DMD) patients. We analyzed the myocardial strain by echocardiography for the early detection of LVSD and determined the predictors of early LVSD. METHODS: Cross-sectional study of forty DMD patients with normal left ventricular ejection fraction. Global longitudinal strain (GLS) was used to analyse subtle disturbances in the longitudinal contraction of the myocardium...
February 14, 2018: Muscle & Nerve
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