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https://www.readbyqxmd.com/read/29124460/medical-egg-freezing-the-importance-of-a-patient-centered-approach-to-fertility-preservation
#1
Marcia C Inhorn, Daphna Birenbaum-Carmeli, Lynn M Westphal, Joseph Doyle, Norbert Gleicher, Dror Meirow, Hila Raanani, Martha Dirnfeld, Pasquale Patrizio
PURPOSE: This binational qualitative study of medical egg freezing (MEF) examined women's motivations and experiences, including their perceived needs for patient-centered care in the midst of fertility- and life-threatening diagnoses. METHODS: Forty-five women who had undertaken MEF were interviewed in the USA (33 women) and in Israel (12 women) between June 2014 and August 2016. Interviews lasted approximately 1 h and were conducted by two senior medical anthropologists, one in each country...
November 9, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29121539/clinical-and-biological-significance-of-isolated-y-chromosome-loss-in-myelodysplastic-syndromes-and-chronic-myelomonocytic-leukemia-a-report-from-the-spanish-mds-group
#2
Meritxell Nomdedeu, Arturo Pereira, Xavier Calvo, Joan Colomer, Francesc Sole, Amparo Arias, Candida Gomez, Elisa Luño, Jose Cervera, Montserrat Arnan, Helena Pomares, Fernando Ramos, Itziar Oiartzabal, Blanca Espinet, Carme Pedro, Beatriz Arrizabalaga, María Laura Blanco, Mar Tormo, Jesus Maria Hernandez-Rivas, María Díez-Campelo, Margarita Ortega, David Valcárcel, Maria-Teresa Cedena, Rosa Collado, Javier Grau, Isabel Granada, Guillermo Sanz, Elias Campo, Jordi Esteve, Dolors Costa
Isolate loss of chromosome Y (-Y) in myelodysplastic syndromes (MDS) is associated to a better outcome but it is also well described as an age-related phenomenon. In this study we aimed to analyze the prognostic impact of -Y in the context of the IPSS-R cytogenetic classification, evaluate the clinical significance of the percentage of metaphases with isolated -Y, and test whether finding -Y may predispose to over-diagnose MDS in patients with borderline morphological features. We evaluated 3581 male patients from the Spanish MDS Registry with a diagnosis of MDS or chronic myelomonocytic leukemia (CMML)...
October 28, 2017: Leukemia Research
https://www.readbyqxmd.com/read/29121511/medical-egg-freezing-and-cancer-patients-hopes-fertility-preservation-at-the-intersection-of-life-and-death
#3
Marcia C Inhorn, Daphna Birenbaum-Carmeli, Pasquale Patrizio
Egg freezing (i.e., oocyte cryopreservation) is a new reproductive technology that allows women's eggs to be frozen and stored for future use. Over the past five years, so-called "medical egg freezing" (MEF) has begun to play a major role as a form of fertility preservation for young women with cancer and other fertility-threatening medical conditions. Indeed, women who are candidates for MEF are often facing the "double jeopardy" of fertility loss and potential death. In this article, we examine the experiences of the first generation of women to use MEF in the United States and Israel, two countries where experimental use of MEF began early, and where MEF is now offered clinically in many in vitro fertilization (IVF) clinics...
October 31, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29116388/the-evolutionarily-conserved-factor-sus1-eny2-plays-a-role-in-telomere-length-maintenance
#4
Amparo Galán, Encar García-Oliver, Carme Nuño-Cabanes, Linda Rubinstein, Martin Kupiec, Susana Rodríguez-Navarro
Sus1 is a conserved protein involved in histone H2B de-ubiquitination and mRNA export from the nucleus in eukaryotes. Previous studies implicated Sus1 partners in genome integrity including telomere homeostasis. However, the implication of Sus1 in telomere maintenance remains largely unknown. In this study, we found that yeast Sus1 interacts physically and genetically with factors involved in telomere maintenance and its absence leads to elongated telomeres. Deletion of several of Sus1's partners also leads to longer telomeres...
November 7, 2017: Current Genetics
https://www.readbyqxmd.com/read/29111385/jnk1-inhibition-by-licochalcone-a-leads-to-neuronal-protection-against-excitotoxic-insults-derived-of-kainic-acid
#5
Oriol Busquets, Miren Ettcheto, Ester Verdaguer, Rubén Dario, Carme Auladell, Carlos Beas-Zarate, Jaume Folch, Antoni Camins
The mitogen-activated protein kinase family (MAPK) is an important group of enzymes involved in cellular responses to diverse external stimuli. One of the members of this family is the c-Jun-N-terminal kinase (JNK). The activation of the JNK pathway has been largely associated with the pathogenesis that occurs in epilepsy and neurodegeneration. Kainic acid (KA) administration in rodents is an experimental approach that induces status epilepticus (SE) and replicates many of the phenomenological features of human temporal lobe epilepsy (TLE)...
October 27, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29106544/effects-of-adult-female-rat-androgenization-on-brain-morphology-and-metabolomic-profile
#6
Carmen Perez-Laso, Sebastián Cerdan, Carme Junque, Ángel Gómez, Esperanza Ortega, Mireia Mora, Carlos Avendaño, Esther Gómez-Gil, María Cruz Rodríguez Del Cerro, Antonio Guillamon
Androgenization in adult natal women, as in transsexual men (TM), affects brain cortical thickness and the volume of subcortical structures. In order to understand the mechanism underlying these changes we have developed an adult female rat model of androgenization. Magnetic resonance imaging and spectroscopy were used to monitor brain volume changes, white matter microstructure and ex vivo metabolic profiles over 32 days in androgenized and control subjects. Supraphysiological doses of testosterone prevents aging decrease of fractional anisotropy values, decreased general cortical volume and the relative concentrations of glutamine (Gln) and myo-Inositol (mI)...
July 6, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29106481/blood-concentrations-of-persistent-organic-pollutants-and-unhealthy-metabolic-phenotypes-in-normal-weight-overweight-and-obese-individuals
#7
Magda Gasull, Conxa Castell, Natàlia Pallarès, Carme Miret, José Pumarega, María Te Llez-Plaza, Tomàs López, Jordi Salas-Salvadó, Duk-Hee Lee, Albert Goday, Miquel Porta
Factors underlying metabolic phenotypes, such as the metabolically healthy but obese phenotype, remain unclear. Differences in metabolic phenotypes -particularly, among individuals with a similar body mass index- could be related to concentrations of persistent organic pollutants (POPs). No studies have analyzed POPs and metabolic phenotypes in normal-weight persons. The authors investigated the relationships between serum concentrations of POPs and metabolic phenotypes in 860 normal-weight, overweight, and obese participants in the 2002 Catalan Health Interview Survey (Spain)...
June 30, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29104699/the-application-of-titanium-dioxide-zinc-oxide-fullerene-and-graphene-nanoparticles-in-photodynamic-therapy
#8
REVIEW
Zahraa Youssef, Régis Vanderesse, Ludovic Colombeau, Francis Baros, Thibault Roques-Carmes, Céline Frochot, Habibah Wahab, Joumana Toufaily, Tayssir Hamieh, Samir Acherar, Amirah Mohd Gazzali
Nanoparticles (NPs) have been shown to have good ability to improve the targeting and delivery of therapeutics. In the field of photodynamic therapy (PDT), this targeting advantage of NPs could help ensure drug delivery at specific sites. Among the commonly reported NPs for PDT applications, NPs from zinc oxide, titanium dioxide, and fullerene are commonly reported. In addition, graphene has also been reported to be used as NPs albeit being relatively new to this field. In this context, the present review is organized by these different NPs and contains numerous research works related to PDT applications...
2017: Cancer Nanotechnology
https://www.readbyqxmd.com/read/29067628/two-year-follow-up-of-fall-prediction-among-older-adults-in-an-independent-living-community
#9
Oz Zur, Yitshal Berner, Yair Ohel, Eli Carmeli
Adults over the age of 70 are at risk of falls. Early detection of risk of falls can suggest early interventions. In this study, we attempted to determine valid clinical tests that can differentiate older individuals who are at risk of falling. Older adults from an independent-living community volunteered to participate in this descriptive, cohort study. They were administered the Berg Balance Scale (BBS), Zur Balance Scale (ZBS); Head Shaking Nystagmus Head Impulse Test, Dynamic Visual Acuity, and the Hallpike maneuver for evaluating benign paroxysmal positional vertigo (BPPV); a questionnaire including sociodemographics and a health characteristics survey...
October 25, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29061625/observational-study-of-factors-associated-with-return-of-home-sampling-kits-for-sexually-transmitted-infections-requested-online-in-the-uk
#10
Kaveh Manavi, James Hodson
OBJECTIVES: To investigate factors associated with the return of home sampling kits for sexually transmitted infections (STIs). SETTING: Online STI testing service offered to the residents of Birmingham and Solihull. PARTICIPANTS: All patients requesting STI home sampling kits via the Umbrella sexual health service website between 15 July 2016 and 14 December 2016. INTERVENTIONS: Associations between data collected at online registration and the rate of return of STI home sampling kits within 30 days of request was assessed...
October 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/29055937/reaching-consensus-on-communication-of-critical-laboratory-results-using-a-collective-intelligence-method
#11
Maria Isabel Llovet, Carmen Biosca, Alicia Martínez-Iribarren, Aurora Blanco, Glòria Busquets, María José Castro, Maria Antonia Llopis, Mercè Montesinos, Joana Minchinela, Carme Perich, Judith Prieto, Rosa Ruiz, Núria Serrat, Margarita Simón, Alex Trejo, Josep Maria Monguet, Carlos López-Pablo, Mercè Ibarz
BACKGROUND: There is no consensus in the literature about what analytes or values should be informed as critical results and how they should be communicated. The main aim of this project is to establish consensual standards of critical results for the laboratories participating in the study. Among the project's secondary objectives, establishing consensual procedures for communication can be highlighted. METHODS: Consensus was reached among all participating laboratories establishing the basis for the construction of the initial model put forward for consensus in conjunction with the clinicians...
October 23, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29048941/patient-perceptions-of-the-adequacy-of-supplemental-oxygen-therapy-results-of-the-american-thoracic-society-nursing-assembly-oxygen-working-group-survey
#12
Susan S Jacobs, Kathleen O Lindell, Eileen G Collins, Chris M Garvey, Carme Hernandez, Sally McLaughlin, Ann M Schneidman, Paula M Meek
RATIONALE: Pulmonary clinicians and patients anecdotally report barriers to home supplemental oxygen services including inadequate supply, unacceptable portable options, and equipment malfunction. Limited evidence exists to describe or quantify these problems. OBJECTIVE: To describe the frequency and type of problems experienced by supplemental oxygen users in the United States. METHODS: The Patient Supplemental Oxygen Survey, a self-report questionnaire, was posted on the American Thoracic Society (ATS) Public Advisory Roundtable and patient and healthcare-affiliated websites...
October 19, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29039133/the-experience-of-implementing-urban-heart-barcelona-a-tool-for-action
#13
Ana M Novoa, Glòria Pérez, Albert Espelt, Cynthia Echave, Patricia G de Olalla, M Jesús Calvo, Maribel Pasarín, Èlia Diez, Carme Borrell, M Jesús Calvo, Berta Cormenzana, Imma Cortés, Èlia Diez, Cynthia Echave, Albert Espelt, Patrícia G de Olalla, Josep Gòmez, Ana M Novoa, Montserrat Pallarès, Glòria Pérez, Maica Rodríguez-Sanz
Urban Health Equity Assessment and Response Tool (HEART) is a tool developed by the World Health Organization whose objective is to provide evidence on urban health inequalities so as to help to decide the best interventions aimed to promote urban health equity. The aim of this paper is to describe the experience of implementing Urban HEART in Barcelona city, both the adaptation of Urban HEART to the city of Barcelona, its use as a means of identifying and monitoring health inequalities among city neighbourhoods, and the difficulties and barriers encountered throughout the process...
October 16, 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/29020250/empiric-therapy-with-carbapenem-sparing-regimens-for-bloodstream-infections-due-to-extended-spectrum-%C3%AE-lactamase-producing-enterobacteriaceae-results-from-the-increment-cohort
#14
Zaira Raquel Palacios-Baena, Belén Gutiérrez-Gutiérrez, Esther Calbo, Benito Almirante, Pierluigi Viale, Antonio Oliver, Vicente Pintado, Oriol Gasch, Luis Martínez-Martínez, Johann Pitout, Murat Akova, Carmen Peña, José Molina Gil-Bermejo, Alicia Hernández, Mario Venditti, Nuria Prim, German Bou, Evelina Tacconelli, Mario Tumbarello, Axel Hamprecht, Helen Giamarellou, Manel Almela, Federico Pérez, Mitchell J Schwaber, Joaquín Bermejo, Warren Lowman, Po-Ren Hsueh, José Ramón Paño-Pardo, Julián Torre-Cisneros, Maria Souli, Robert A Bonomo, Yehuda Carmeli, David L Paterson, Álvaro Pascual, Jesús Rodríguez-Baño
Background: There is little information about the efficacy of active alternative drugs to carbapenems except β-lactam/β-lactamase inhibitors for the treatment of bloodstream infections (BSIs) due to extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E). The objective of this study was to assess the outcomes of patients with BSI due to ESBL-E who received empiric therapy with such drugs (other active drugs [OADs]) or carbapenems. Methods: A multinational retrospective cohort study of patients with BSI due to ESBL-E who received empiric treatment with OADs or carbapenems was performed...
October 30, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29020228/the-impact-of-a-carbapenem-resistant-enterobacteriaceae-outbreak-on-facilitating-development-of-a-national-infrastructure-for-infection-control-in-israel
#15
Mitchell J Schwaber, Yehuda Carmeli
In 2006 the Israeli healthcare system faced an unprecedented outbreak of carbapenem-resistant Enterobacteriaceae, primarily involving KPC-producing Klebsiella pneumoniae clonal complex CC258. This public health crisis exposed major gaps in infection control. In response, Israel established a national infection control infrastructure. The steps taken to build this infrastructure and benefits realized from its creation are described here.
July 19, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29018011/balance-versus-hearing-after-cochlear-implant-in-an-adult
#16
Oz Zur, Hadas Ben-Rubi Shimron, Gerry Leisman, Eli Carmeli
The effect of vestibular rehabilitation (VR) on anxiety, dizziness and poor balance that developed after cochlear implant (CI) surgery is described. A 54-year-old woman, with profound hearing loss since the age of 2 years, underwent right CI surgery 2 years previously. On implant activation, the patient immediately felt dizziness and imbalance, which affected the ability to perform activities of daily living and increased anxiety to where the patient considered the CI removal. Prior to VR the patient was evaluated with the Dizziness Handicap Inventory and the Visual Vertigo Dizziness Questionnaire and clinically with the Zur Balance Scale and Video Head Impulse Test...
October 10, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28993095/comparison-of-the-brainstem-auditory-evoked-responses-during-sevoflurane-or-alfaxalone-anaesthesia-in-adult-cats
#17
Carlos Ros, Carme Soler, Alejandra García de Carellán Mateo
OBJECTIVE: To compare the effects of general anaesthesia using sevoflurane or alfaxalone on the brainstem auditory evoked response (BAER) test in adult healthy cats. STUDY DESIGN: Prospective, clinical, 'blinded', crossover study. ANIMALS: Ten feral adult healthy cats. METHODS: Premedication consisted of dexmedetomidine (0.01 mg kg(-1)) intramuscularly (IM). The first general anaesthesia was induced and maintained with sevoflurane (treatment S) for physical examination, BAER test, complete blood tests, thoracic radiographs and abdominal ultrasound...
March 2, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28987858/-effectiveness-of-an-educational-program-for-respiratory-rehabilitation-of-chronic-obstructive-pulmonary-disease-patients-in-primary-care-in-improving-the-quality-of-life-symptoms-and-clinical-risk
#18
Cristina Blánquez Moreno, Cristina Colungo Francia, M Carme Alvira Balada, Belchin Kostov, Luis González-de Paz, Antoni Sisó-Almirall
AIM: To determine the impact of an educational program to improve the management of chronic obstructive pulmonary disease (COPD) that contributes to an increase of the quality of life, exercise capacity, level of dyspnoea, and clinical risk. DESIGN: Intervention study without controls. LOCATION: Primary Healthcare Centre. PARTICIPANTS: 193 patients with COPD were invited, 73 accepted and 55 participated in the educational program...
October 4, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/28981629/usefulness-of-transcriptional-blood-biomarkers-as-a-non-invasive-surrogate-marker-of-mucosal-healing-and-endoscopic-response-in-ulcerative-colitis
#19
Núria Planell, M Carme Masamunt, Raquel Franco Leal, Lorena Rodríguez, Miriam Esteller, Juan J Lozano, Anna Ramírez, Maria de Lourdes Setsuko Ayrizono, Claudio Saddy Rodrigues Coy, Ignacio Alfaro, Ingrid Ordás, Sudha Visvanathan, Elena Ricart, Jordi Guardiola, Julián Panés, Azucena Salas
Background and Aims: Ulcerative colitis [UC] is a chronic inflammatory disease of the colon. Colonoscopy remains the gold standard for evaluating disease activity, as clinical symptoms are not sufficiently accurate. The aim of this study is to identify new accurate non-invasive biomarkers based on whole-blood transcriptomics that can predict mucosal lesions and response to treatment in UC patients. Methods: Whole-blood samples were collected for a total of 152 UC patients at endoscopy...
October 27, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28980273/specialized-pain-clinics-in-primary-care-common-diagnoses-referral-patterns-and-clinical-outcomes-novel-pain-management-model
#20
Yacov Fogelman, Eli Carmeli, Amir Minerbi, Baruch Harash, Simon Vulfsons
An estimated 19% of the adult population in western countries lives with chronic pain. Pain management lies mainly within the primary care and community setting. We evaluated the outcome of a new model of secondary care clinics, conducted by primary care physicians with specialized training in pain medicine. Data on referral patterns, prevalence of pain diagnosis, and medication consumption were recorded at five secondary pain management clinics in the community setting. In total, 997 patients with pain attended 2,652 visits (average 2...
October 5, 2017: Advances in Experimental Medicine and Biology
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