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https://www.readbyqxmd.com/read/28903797/prevalence-of-anti-hepatitis-b-surface-antibodies-among-children-and-adolescents-vaccinated-in-infancy-and-effect-of-booster-dose-administered-within-a-pilot-study
#1
R Bassal, M P Markovich, M Weil, E Shinar, Y Carmeli, M Dan, D Sofer, E Mendelson, D Cohen, T Shohat
We determined the prevalence of anti-hepatitis B surface antibodies (anti-HBs) among children and adolescents vaccinated for hepatitis B virus in infancy as part of the routine vaccination programme. A representative serum sample of the Israeli population age 0-19 was tested. In a separate pilot study, a booster dose of hepatitis B vaccine was administered to 31 candidates for national service, who were fully vaccinated in infancy and tested negative for hepatitis B surface antibodies at age 17-19 years and anti-HBs antibodies were assessed 8 weeks later...
September 14, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28893585/thermo-responsive-magnetic-fe3o4-p-meo2max-oegma100-x-nps-and-their-applications-as-drug-delivery-systems
#2
Enaam Jamal Al Dine, Zied Ferjaoui, Jaafar Ghanbaja, Thibault Roques-Carmes, Abdelaziz Meftah, Tayssir Hamieh, Joumana Toufaily, Raphaël Schneider, Sophie Marchal, Eric Gaffet, Halima Alem
The unique physical properties of the superparamagnetic nanoparticles (SPIONs) have made them candidates of choice in nanomedicine especially for diagnostic imaging, therapeutic applications and drug delivery based systems. In this study, superparamagnetic Fe3O4 NPs were synthesized and functionalized with a biocompatible thermoresponsive copolymer to obtain temperature responsive core/shell NPs. The ultimate goal of this work is to build a drug delivery system able to release anticancer drugs in the physiological temperatures range...
September 8, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28884377/idh-mutation-status-trumps-the-pignatti-risk-score-as-a-prognostic-marker-in-low-grade-gliomas
#3
Olatz Etxaniz, Cristina Carrato, Itziar de Aguirre, Cristina Queralt, Ana Muñoz, José L Ramirez, Rafael Rosell, Salvador Villà, Rocio Diaz, Ana Estival, Pilar Teixidor, Alberto Indacochea, Sara Ahjal, Laia Vilà, Carme Balañá
Management of low-grade gliomas (LGG) is based on clinical and radiologic features, including the Pignatti prognostic scoring system, which classifies patients as low- or high-risk. To determine whether molecular data can offer advantages over these features, we have examined the prognostic impact of several molecular alterations in LGG. In a cohort of 58 patients with LGG, we have retrospectively analyzed clinical and molecular characteristics, including the Pignatti criteria, IDH mutations, TP53 mutations, the 1p/19q deletion, and MGMT methylation, and correlated our findings with progression-free survival (PFS) and overall survival (OS)...
September 7, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28881664/prognostic-micrornas-in-upper-tract-urothelial-carcinoma-multicenter-and-international-validation-study
#4
Laura Izquierdo, Ruth Montalbo, Mercedes Ingelmo-Torres, Carme Mallofré, Miguel Ramírez-Backhaus, Jose Rubio, Antoine G Van der Heijden, Ewout Schaafsma, Antonio Lopez-Beltran, Ana Blanca, Nathan Lawrentschuk, Antonio Alcaraz, Lourdes Mengual
OBJECTIVE: To validate previously discovered miRNAs (miR-31-5p and miR-149-5p) as prognostic factors for UTUC in an independent cohort of UTUC patients. PATIENTS AND METHODS: Multicenter, international and retrospective study of formalin-fixed paraffin-embedded tissue samples from 103 UTUC patients (45 progressing and 58 non-progressing) who underwent radical nephroureterectomy. Total RNA was isolated and reverse transcribed. The expression of target miRNAs (miR-31-5p and miR-149-5p) and the endogenous control miR-218-5p was evaluated in all samples by reverse transcription quantitative PCR...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28878530/oldest-epiphyseal-osteochondroma-in-a-subadult-from-ancient-egypt
#5
Albert Isidro, Josep Maria Catalán, Carme Prat, Ferran Torner
Benign bone tumours are pathologies frequently encountered in archaeological human remains, with the most common being osteoma and osteochondroma. We present the case of a juvenile individual recovered from the Necropolis of Sharuna, Middle Egypt and dated to the end of Old Kingdom and First Intermediate Period of Ancient Egypt (circa 2150 BC), showing an osteochondroma arising from the proximal epiphysis of the right tibia which, in all likelihood, affected the patellar tendon in life. Osteochondromas are usually discovered during childhood and adolescence...
August 2017: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28851430/evolution-of-gender-representation-among-canadian-otl-hns-residents-a-27-year-analysis
#6
Sarah Chorfi, Joseph S Schwartz, Neil Verma, Meredith Young, Lawrence Joseph, Lily H P Nguyen
BACKGROUND: The proportion of females enrolling into medical schools has been growing steadily. However, the representation of female residents among individual specialties has shown considerable variation. The purpose of this study was to compare the trends of gender representation in Otolaryngology - Head and Neck Surgery (OTL-HNS) residency programs with other specialty training programs in Canada. In order to contextualize these findings, a second phase of analysis examined the success rate of applicants of different genders to OTL-HNS residency programs...
August 29, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28842977/clinical-outcomes-after-external-cephalic-version-with-spinal-anesthesia-after-failure-of-a-first-attempt-without-anesthesia
#7
Manal Massalha, Gali Garmi, Noah Zafran, Julia Carmeli, Genady Gimburg, Raed Salim
OBJECTIVE: To determine whether repeat external cephalic version (ECV) with spinal anesthesia affects clinical outcomes and cesarean delivery rates. METHODS: A retrospective study was conducted using data collected at one hospital in Israel between January 1, 2009, and December 31, 2015. Women with non-vertex singleton pregnancies (≥37 weeks) who had a failed ECV attempt without spinal anesthesia were included in the analysis. All women were offered a repeat ECV with spinal anesthesia...
August 26, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28832601/educational-expansion-and-inequalities-in-mortality-a-fixed-effects-analysis-using-longitudinal-data-from-18-european-populations
#8
Olof Östergren, Olle Lundberg, Barbara Artnik, Matthias Bopp, Carme Borrell, Ramune Kalediene, Mall Leinsalu, Pekka Martikainen, Enrique Regidor, Maica Rodríguez-Sanz, Rianne de Gelder, Johan P Mackenbach
OBJECTIVE: The aim of this paper is to empirically evaluate whether widening educational inequalities in mortality are related to the substantive shifts that have occurred in the educational distribution. MATERIALS AND METHODS: Data on education and mortality from 18 European populations across several decades were collected and harmonized as part of the Demetriq project. Using a fixed-effects approach to account for time trends and national variation in mortality, we formally test whether the magnitude of relative inequalities in mortality by education is associated with the gender and age-group specific proportion of high and low educated respectively...
2017: PloS One
https://www.readbyqxmd.com/read/28831971/capacity-of-milk-composition-to-identify-the-feeding-system-used-to-feed-dairy-cows
#9
Fernando Vicente, Carme Santiago, José D Jiménez-Calderón, Adela Martínez-Fernández
This Research Paper addresses the hypothesis that is possible to identify the type of feed used for dairy cows by means of the analysis of milk composition and the fatty acid profile of milk fat. Sixteen dairy farms were monitored during 1 year with quarterly visits between summer 2014 and spring 2015. Rations varied throughout the year due to annual dynamic change of forage production, forage rotation, variation of nutrient requirements according to physiological state of the animal, etc. The ingredients of the rations were analysed by cluster identifying five feeding systems based on the main ingredient of the diet: grazing, maize silage, grass silage, dry forage and concentrate...
August 2017: Journal of Dairy Research
https://www.readbyqxmd.com/read/28825894/adhesion-and-invasion-to-epithelial-cells-and-motility-of-extended-spectrum-%C3%AE-lactamase-producing-escherichia-coli-reveal-st131-superiority-a-comparative-in-vitro-study-of-extraintestinal-pathogenic-e-coli-lineages
#10
Kira Kondratyeva, Ayala Wollman, Gabi Gerlitz, Shiri Navon-Venezia
PURPOSE: Extended-spectrum β-lactamase (ESBL)-producing extraintestinal pathogenic Escherichia coli (ExPEC) sequence type ST131 is pandemic, and it is the major contributor to antibiotic resistance in E. coli. Despite its epidemiological superiority, the physiological reasons that decipher its success remain elusive. We aimed to compare the adhesion, invasion and motility potential of ST131 versus other E. coli lineages. METHODOLOGY: In this in vitro comparative study, 14 ESBL-producing ExPEC community-onset bacteremia isolates were chosen from a reported clinical collection (Karfunkel D, Carmeli Y, Chmelnitsky I, Kotlovsky T, Navon-Venezia S...
September 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28802549/diffuse-renal-cortical-hemorrhage-in-the-setting-of-subcapsular-hematoma-diagnosis-and-treatment-with-embolization
#11
Marta Burrel, Marta Barrufet, Maria Carme Sebastia, Jonathan Joudanin, Laura Buñesch, Patricia Bermudez, Jordi Blasco, Rosa Gilabert
PURPOSE: To describe radiologic findings, embolization technique, and clinical outcomes in patients with renal subcapsular hematoma and diffuse cortical hemorrhage. MATERIALS AND METHODS: Ten patients with renal subcapsular hematoma and diffuse cortical hemorrhage were reviewed. Nine of the 10 had undergone procedures (nephrostomy, n = 4; biopsy, n = 4; embolization of a cerebral aneurysm, n = 1) and 1 patient was receiving oral anticoagulation. Computed tomography (CT), angiography, and embolization of bleeding sites were performed in all patients...
August 9, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28782704/geographical-variation-in-therapy-for-bloodstream-infections-due-to-multidrug-resistant-enterobacteriaceae-a-post-hoc-analysis-of-the-increment-study
#12
Patrick N A Harris, M Diletta Pezzani, Belén Gutiérrez-Gutiérrez, Pierluigi Viale, Po-Ren Hsueh, Patricia Ruiz-Garbajosa, Mario Venditti, Mario Tumbarello, Carolina Navarro-Francisco, Esther Calbo, Murat Akova, Helen Giamarellou, Antonio Oliver, Benito Almirante, Oriol Gasch, Luis Martínez-Martínez, Mitchell J Schwaber, George Daikos, Johann Pitout, Carmen Peña, Alicia Hernández-Torres, Yohei Doi, Federico Pérez, Felipe Francisco Tuon, Evelina Tacconelli, Yehuda Carmeli, Robert A Bonomo, Álvaro Pascual, David L Paterson, Jesús Rodríguez-Baño
We aimed to describe regional differences in therapy for bloodstream infection (BSI) caused by extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) or carbapenemase-producing Enterobacteriaceae (CPE). 1,482 patients in 12 countries were included from an observational study of BSI caused by ESBL-E or CPE. Multivariate logistic regression was used to calculate adjusted odds ratios (aORs) for the influence of country of recruitment on empirical use of β-lactam/β-lactamase inhibitors (BLBLI) or carbapenems, targeted use of BLBLI for ESBL-E and use of targeted combination therapy for CPE...
August 3, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28776021/1-6-cyclophellitol-cyclosulfates-a-new-class-of-irreversible-glycosidase-inhibitor
#13
Marta Artola, Liang Wu, Maria J Ferraz, Chi-Lin Kuo, Lluís Raich, Imogen Z Breen, Wendy A Offen, Jeroen D C Codée, Gijsbert A van der Marel, Carme Rovira, Johannes M F G Aerts, Gideon J Davies, Herman S Overkleeft
The essential biological roles played by glycosidases, coupled to the diverse therapeutic benefits of pharmacologically targeting these enzymes, provide considerable motivation for the development of new inhibitor classes. Cyclophellitol epoxides and aziridines are recently established covalent glycosidase inactivators. Inspired by the application of cyclic sulfates as electrophilic equivalents of epoxides in organic synthesis, we sought to test whether cyclophellitol cyclosulfates would similarly act as irreversible glycosidase inhibitors...
July 26, 2017: ACS Central Science
https://www.readbyqxmd.com/read/28766587/an-atypical-interaction-explains-the-high-affinity-of-a-non-hydrolyzable-s-linked-1-6-%C3%AE-mannanase-inhibitor
#14
Tyson Belz, Yi Jin, Joan Coines, Carme Rovira, Gideon J Davies, Spencer J Williams
The non-hydrolyzable S-linked azasugars, 1,6-α-mannosylthio- and 1,6-α-mannobiosylthioisofagomine, were synthesized and shown to bind with high affinity to a family 76 endo-1,6-α-mannanase from Bacillus circulans. X-ray crystallography showed an atypical interaction of the isofagomine nitrogen with the catalytic acid/base. Molecular dynamics simulations reveal that the atypical binding results from sulfur perturbing the most stable form away from the nucleophile interaction preferred for the O-linked congener...
August 2, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28752224/early-preclinical-changes-in-hippocampal-creb-binding-protein-expression-in-a-mouse-model-of-familial-alzheimer-s-disease
#15
Miren Ettcheto, Sonia Abad, Dmitry Petrov, Ignacio Pedrós, Oriol Busquets, Elena Sánchez-López, Gemma Casadesús, Carlos Beas-Zarate, Eva Carro, Carme Auladell, Jordi Olloquequi, Merce Pallàs, Jaume Folch, Antoni Camins
The molecular basis of memory loss in Alzheimer's disease (AD), the main cause of senile dementia, is under investigation. In the present study, we have focused on the early hippocampal memory-related changes in APPswe/PS1dE9 (APP/PS1) mice, a well-established mouse model of familial AD. It is well known that molecules like cAMP response element binding (CREB) and binding protein (CBP) play a crucial role in memory consolidation. We analyzed CBP on its transcriptional activity and protein levels, finding a significant downregulation of both of them at 3-month-old mice...
July 27, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28738268/descriptive-epidemiology-of-primary-malignant-and-non-malignant-central-nervous-tumors-in-spain-results-from-the-girona-cancer-registry-1994-2013
#16
Rafael Fuentes-Raspall, Marta Solans, Aina Roca-Barceló, Loreto Vilardell, Montse Puigdemont, Sonia Del Barco, Raquel Comas, Adelaida García-Velasco, Aurora Astudillo, Mª Carme Carmona-Garcia, Rafael Marcos-Gragera
BACKGROUND: Systematic registration of non-malignant central nervous system (CNS) tumors is a rare practice among European cancer registries. Thus, the real burden of all CNS tumors across Europe is underestimated. The Girona Cancer Registry provides here the first data on CNS tumor incidence and survival trends in Spain for all histological types, including malignant and non-malignant tumors. METHODS: Data on all incident cases of primary CNS tumors notified to the Girona population-based cancer registry from 1994 to 2013 (n=2,131) were reviewed...
July 21, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28730230/magnetic-nanoparticles-based-therapy-for-malignant-mesothelioma
#17
Ion Mîndrilă, Sandra Alice Buteică, Dan Eduard Mihaiescu, Florin Burada, Bogdan Mîndrilă, Maria Cristina Predoi, Ionica Pirici, Adrian Fudulu, Octavian Croitoru
This work was aimed to analyze the versatility of the chick embryo chorioallantoic membrane (CAM) as in vivo model for the study of the malignant pleural mesothelioma (MPM) and the therapeutic potential of Fe3O4÷salicylic acid magnetic nanoparticles (SaMNPs) on MPM cells. The antitumor effects of SaMNPs were studied by in vitro and in vivo tests on CARM-L12 TG3 rat malignant mesothelioma cells and human MPM xenografts implanted on CAMs. In order to assess the human MPM xenograft growth characteristics, calretinin, HBME-1 (Hector Battifora mesothelial epitope-1), and cytokeratins immunohistochemical stainings were performed...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28724308/eus-guided-recanalization-of-complete-gastrointestinal-strictures
#18
Miguel Martínez-Guillén, Joan B Gornals, Claudia F Consiglieri, Josep M Castellvi, Carme Loras
BACKGROUND AND AIM: Complete gastrointestinal strictures are a technically demanding problem. In this setting, an anterograde technique is associated with a high risk of complications and a combined anterograde-retrograde technique requires a prior ostomy. Our aim was to assess the outcome of a first case series for the management of complete gastrointestinal strictures using endoscopic ultrasound (EUS)-guided puncture as a novel endoscopic approach. PATIENTS AND METHODS: This retrospective case-series describes four cases that were referred for treatment of complete benign gastrointestinal strictures, three upper and one lower...
July 14, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28714429/structural-brain-correlations-of-visuospatial-and-visuoperceptual-tests-in-parkinson-s-disease
#19
Anna Isabel Garcia-Diaz, Barbara Segura, Hugo Cesar Baggio, Maria Jose Marti, Francesc Valldeoriola, Yaroslau Compta, Nuria Bargallo, Carme Uribe, Anna Campabadal, Alexandra Abos, Carme Junque
BACKGROUND: Diagnosis of mild cognitive impairment in Parkinson's disease (PD) is relevant because it is a marker for evolution to dementia. However, the selection of suitable tests to evaluate separate cognitive domains in mild cognitive impairment related to PD remains an open question. The current work aims to investigate the neuroanatomical correlates of several visuospatial/visuoperceptual tests using the same sample and a multimodal MRI approach. METHODS: The study included 36 PD patients and 20 healthy subjects matched for age, sex, and education...
July 17, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28710482/protocol-for-regional-implementation-of-community-based-collaborative-management-of-complex-chronic-patients
#20
Isaac Cano, Ivan Dueñas-Espín, Carme Hernandez, Jordi de Batlle, Jaume Benavent, Juan Carlos Contel, Erik Baltaxe, Joan Escarrabill, Juan Manuel Fernández, Judith Garcia-Aymerich, Miquel Àngel Mas, Felip Miralles, Montserrat Moharra, Jordi Piera, Tomas Salas, Sebastià Santaeugènia, Nestor Soler, Gerard Torres, Eloisa Vargiu, Emili Vela, Josep Roca
No abstract text is available yet for this article.
July 14, 2017: NPJ Primary Care Respiratory Medicine
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