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https://www.readbyqxmd.com/read/29147780/the-effect-of-removing-numerically-dominant-non-native-honey-bees-on-seed-set-of-a-native-plant
#1
Annika J Nabors, Henry J Cen, Keng-Lou J Hung, Joshua R Kohn, David A Holway
Pollination services are compromised by habitat destruction, land-use intensification, pesticides, and introduced species. How pollination services respond to such stressors depends on the capacity of pollinator assemblages to function in the face of environmental disruption. Here, we quantify how pollination services provided to a native plant change upon removal of the non-native, western honey bee (Apis mellifera)-a numerically dominant floral visitor in the native bee-rich ecosystems of southern California...
November 16, 2017: Oecologia
https://www.readbyqxmd.com/read/29146411/metabolic-adaptation-to-intermittent-fasting-is-independent-of-peroxisome-proliferator-activated-receptor-alpha
#2
Guolin Li, Chad N Brocker, Tingting Yan, Cen Xie, Kristopher W Krausz, Rong Xiang, Frank J Gonzalez
BACKGROUND: Peroxisome proliferator-activated receptor alpha (PPARA) is a major regulator of fatty acid oxidation and severe hepatic steatosis occurs during acute fasting in Ppara-null mice. Thus, PPARA is considered an important mediator of the fasting response; however, its role in other fasting regiments such as every-other-day fasting (EODF) has not been investigated. METHODS: Mice were pre-conditioned using either a diet containing the potent PPARA agonist Wy-14643 or an EODF regimen prior to acute fasting...
November 6, 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29141109/hepatic-ppar%C3%AE-mediates-the-major-metabolic-effects-of-wy-14643
#3
Guolin Li, Chad N Brocker, Cen Xie, Tingting Yan, Audrey Noguchi, Kristopher W Krausz, Rong Xiang, Frank J Gonzalez
BACKGROUND AND AIM: Peroxisome proliferator-activated receptor alpha (PPARα) is a molecular target of various fibrate drugs clinically used to lower serum lipids. However, the tissue-specific functions of PPARα remain to be elucidated. This study aimed to explore the tissue-specific functions of PPARα in response to Wy-14643. METHODS: A hepatocyte-specific Ppara knockout mouse line was used to explore the impact of hepatic PPARα activity on the systemic response to treatment with the potent PPARα agonist Wy-14643...
November 15, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29139255/-association-rules-analysis-for-exploring-combined-medication-characteristics-of-fufang-kushen-injection-real-world-study-based-on-49-597-cases
#4
Yin Zhang, Yan-Ming Xie, Yan-Nan Li, Chang Zhang, Cen Chen, Yan Zhuang
The present study aimed to analyze the association rules of Fufang Kushen injection in combined medications in the real world based on electrical medical records in hospital information system, and provide reference for its reasonable clinical application. The electrical medical records of the hospitalized patients using Fufang Kushen injection were extracted to analyze the frequency distribution characteristics in combined application with Western medicine, and analyze the specific association rules between these combinations by using Apriori algorithm...
August 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29139251/-clinical-application-features-of-fufang-kushen-injection-in-treating-malignant-esophageal-tumor%C3%AF-real-world-study-based-on-hospital-information-system
#5
Ya-Xin Liu, Zhi-Fei Wang, Yan-Ming Xie, Yin Zhang, Cen Chen, Yan Zhuang
To analyze the clinical application features of Fufang Kushen injection in treating malignant esophageal tumors in the real world by using hospital information system database, and provide reference for clinical application of Fufang Kushen injection. The electronic medical data from 2 550 patients with malignant esophageal tumors using Fufang Kushen injection from 22 large-scale hospitals nationwide were extracted based on the hospital information system (HIS) established by Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences...
August 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29136022/prognostic-significance-of-cytokeratin-19-expression-in-pancreatic-neuroendocrine-tumor-a-meta-analysis
#6
Dong Cen, Jiang Chen, Zheyong Li, Jie Zhao, Xiujun Cai
BACKGROUND: Pancreatic neuroendocrine tumor (PNET) comprises 1-2% of all pancreatic tumors, but its incidence is increasing. Although many studies have investigated the correlation between cytokeratin 19 (CK-19) and PNET, the prognostic significance of CK-19 expression in PNET is inconclusive. METHODS: Eligible studies were retrieved from Pubmed, Elsevier, Embase, Cochrane Library and Web of Science databases. All relevant data were extracted to analyze the relationship between CK-19 and PNET...
2017: PloS One
https://www.readbyqxmd.com/read/29133434/pkd1-promotes-functional-synapse-formation-coordinated-with-n-cadherin-in-hippocampus
#7
Cheng Cen, Li-Da Luo, Wen-Qi Li, Gang Li, Na-Xi Tian, Ge Zheng, Dong-Min Yin, Yimin Zou, Yun Wang
Functional synapse formation is critical for the wiring of neural circuits in the developing brain. The cell adhesion molecule N-cadherin plays important roles in target recognition and synaptogenesis. However, the molecular mechanisms that regulate the localization of N-cadherin and the subsequent effects remain poorly understood. Here, we show that protein kinase D1 (PKD1) directly binds to N-cadherin at amino acid residues 836-871 and phosphorylates it at Ser 869, 871, 872, thereby increasing the surface localization of N-cadherin and promoting functional synapse formation in primary cultured hippocampal neurons obtained from embryonic day 18 rat embryos of either sex...
November 13, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29130326/resting-state-network-functional-connectivity-patterns-associated-with-the-mindful-attention-awareness-scale
#8
Elena Bilevicius, Stephen D Smith, Jennifer Kornelsen
Mindfulness refers to attending to moment-to-moment experiences with acceptance and no judgment. Several scales have been developed to quantify different components of mindfulness. The Mindful Attention Awareness Scale (MAAS) is particularly sensitive to trait mindfulness and is proposed to measure the attentional component of mindfulness. The purpose of the current study was to identify the neural correlates of the MAAS in four resting state networks related to attention-the default mode network (DMN), the salience network (SN), and the left and right central executive network (lCEN and rCEN)...
November 12, 2017: Brain Connectivity
https://www.readbyqxmd.com/read/29130128/effect-of-cys-gsh-and-ph-on-mercury-release-from-tibetan-medicine-zuotai-%C3%AE-hgs-and-%C3%AE-hgs-in-artificial-gastrointestinal-juices
#9
Zhiyuan Zheng, Ming Zhang, Yuancan Xiao, Lixin Wei, Cen Li
Zuotai, also named as "gTso thal", a known Tibetan medicinal mixture containing insoluble cubic crystal mercuric sulfide (β-HgS), has been used to treat diseases with long history. The mercury release ratio from Zuotai in gastrointestinal environment is one determinant factor for its bioavailability and biological effect. However, the information is still scarce now. Therefore, the study was designed to investigate the effect of sulfhydryl biomolecules [L-cysteine (Cys) and glutathione (GSH)] and pH on mercury dissociation from Zuotai, β-HgS, and hexagonal crystal mercuric sulfide (α-HgS) in artificial gastrointestinal juices or pure water with a 1:100 solid-liquid ratio...
November 12, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/29122848/reducing-insulin-via-conditional-partial-gene-ablation-in-adults-reverses-diet-induced-weight-gain
#10
Melissa M Page, Søs Skovsø, Haoning Cen, Amy P Chiu, Derek A Dionne, Daria F Hutchinson, Gareth E Lim, Marta Szabat, Stephane Flibotte, Sunita Sinha, Corey Nislow, Brian Rodrigues, James D Johnson
Excess circulating insulin is associated with obesity in humans and in animal models. However, the physiologic causality of hyperinsulinemia in adult obesity has rightfully been questioned because of the absence of clear evidence that weight loss can be induced by acutely reversing diet-induced hyperinsulinemia. Herein, we describe the consequences of inducible, partial insulin gene deletion in a mouse model in which animals have already been made obese by consuming a high-fat diet. A modest reduction in insulin production/secretion was sufficient to cause significant weight loss within 5 wk, with a specific effect on visceral adipose tissue...
November 9, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29117546/intermittent-fasting-promotes-white-adipose-browning-and-decreases-obesity-by-shaping-the-gut-microbiota
#11
Guolin Li, Cen Xie, Siyu Lu, Robert G Nichols, Yuan Tian, Licen Li, Daxeshkumar Patel, Yinyan Ma, Chad N Brocker, Tingting Yan, Kristopher W Krausz, Rong Xiang, Oksana Gavrilova, Andrew D Patterson, Frank J Gonzalez
No abstract text is available yet for this article.
November 7, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/29115526/the-long-non-coding-rna-enst00000547547-reduces-5-fluorouracil-resistance-of-colorectal-cancer-cells-via-competitive-binding-to-microrna-31
#12
Jian Li, Xiaorong Li, Chaoqun Cen, Xiaohui Ai, Changwei Lin, Gui Hu
Colorectal cancer (CRC) is one of the most common cancers and the third leading cause of cancer-related deaths due to its rapid progression and poor prognosis. 5-Fluorouracil (5-FU)-based chemotherapies are the standard treatment for locally advanced CRC. However, a considerable percentage of CRCs have inherent or acquired 5-FU resistance, which critically impedes clinical outcomes. In the present study, we reported that the expression level ENST00000547547 was downregulated in 5-FU-resistant CRC cells in comparison with the parental cells, While rising with the treatment of 5-FU in parental cells...
November 7, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29113912/arid1a-regulates-response-to-anti-angiogenic-therapy-in-advanced-hepatocellular-carcinoma
#13
Chaobo Hu, Weiping Li, Feng Tian, Kai Jiang, Xiaoting Liu, Jin Cen, Qiang He, Zhixin Qiu, Yvonne Kienast, Zhong Wang, Haibin Zhang, Yuan Ji, Junhao Hu, Lijian Hui
BACKGROUND & AIMS: Arid1a, a component of the chromatin-remodelling complex, has emerged as a tumor suppressor gene. It is frequently mutated in hepatocellular carcinoma (HCC). However, it remains unknown how Arid1a suppresses HCC development and whether Arid1a deficiency could be exploited for therapy. METHODS: The expression of Arid1a in human and mouse HCCs was determined by immunohistochemical (IHC) staining. Gene expression was determined by qPCR, ELISA or Western blotting...
November 4, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29108981/outcomes-of-per-oral-endoscopic-myotomy-for-treatment-of-esophageal-achalasia-with-a-median-follow-up-of-49-months
#14
Quan-Lin Li, Qiu-Ning Wu, Xiao-Cen Zhang, Mei-Dong Xu, Wei Zhang, Shi-Yao Chen, Yun-Shi Zhong, Yi-Qun Zhang, Wei-Feng Chen, Wen-Zheng Qin, Jian-Wei Hu, Ming-Yan Cai, Li-Qing Yao, Ping-Hong Zhou
BACKGROUND AND AIMS: Per-oral endoscopic myotomy (POEM) has received wide acceptance as a highly effective and safe treatment for esophageal achalasia. Short-term and small-scale studies are ample but long-term large-scale studies are few. The aim of the study was to systematically analyze our long-term results of POEM, with particular emphasis on POEM failures and associated risk factors. METHODS: This is a single-center study. Consecutive POEM patients between August 2010 and December 2012 were included...
November 3, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29101089/comparison-of-the-metabolic-response-to-over-production-of-p-coumaric-acid-in-two-yeast-strains
#15
Angelica Rodriguez, Yun Chen, Sakda Khoomrung, Emre Özdemir, Irina Borodina, Jens Nielsen
The development of robust and efficient cell factories requires understanding of the metabolic changes triggered by the production of the targeted compound. Here we aimed to study how production of p-coumaric acid, a precursor of multiple secondary aromatic metabolites, influences the cellular metabolism of Saccharomyces cerevisiae. We evaluated the growth and p-coumaric acid production in batch and chemostat cultivations and analyzed the transcriptome and intracellular metabolome during steady state in low- and high-producers of p-coumaric acid in two strain backgrounds, S288c or CEN...
October 31, 2017: Metabolic Engineering
https://www.readbyqxmd.com/read/29098726/a-general-strategy-for-synthesis-of-ptm-m-fe-co-ni-decorated-three-dimensional-hollow-graphene-nanospheres-for-efficient-methanol-electro-oxidation
#16
Xiaoyu Qiu, Tiancheng Li, Sihui Deng, Ke Cen, Lin Xu, Yawen Tang
A universal sacrificial template-based synthesis strategy was reported to prepare three dimensional (3D) reduced oxide graphene supported PtM (M = Fe, Co, Ni) hollow nanospheres (PtM/RGO HNSs). The inner 3D wrinkle-free graphene skeleton can promote electron and ion kinetics, resulting in enhancement for the permeation of small organic molecule in fuel cells. As inspired by this, the 3D PtM (M=Fe,Co,Ni)/RGO HNSs exhibits clearly enhanced electrocatalytic activity and durability for methanol reaction (MOR) in acid medium compared with commercial Pt / C catalyst...
November 2, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29093470/functional-divergence-and-intron-variability-during-evolution-of-angiosperm-terminal-flower1-tfl1-genes
#17
Jian Gao, Bing-Hong Huang, Yu-Ting Wan, JenYu Chang, Jun-Qing Li, Pei-Chun Liao
The protein encoded by the TERMINAL FLOWER1 (TFL1) gene maintains indeterminacy in inflorescence meristem to repress flowering, and has undergone multiple duplications. However, basal angiosperms have one copy of a TFL1-like gene, which clusters with eudicot TFL1/CEN paralogs. Functional conservation has been reported in the paralogs CENTRORADIALIS (CEN) in eudicots, and ROOTS CURL IN NPA (RCNs) genes in monocots. In this study, long-term functional conservation and selective constraints were found between angiosperms, while the relaxation of selective constraints led to subfunctionalisation between paralogs...
November 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29091297/effect-of-microrna-128-on-cisplatin-resistance-of-glioma-shg-44-cells-by-targeting-jag1
#18
Dong-Ye Yi, Qing Su, Fang-Cheng Zhang, Peng Fu, Qing Zhang, Yong-Cun Cen, Hong-Yang Zhao, Wei Xiang
This current study intends to investigate the effect of microRNA-128 (miR-128) on cisplatin (DDP) resistance in glioma SHG-44 cells. SHG-44/DDP cells were transfected with miR-128 antisense oligonucleotide (ASO) and assigned into blank, resistance, NC, anti-miR-128, miR-128 mimic, si-JAG1 and anti-miR-128 + si-JAG1 groups. qRT-PCR and western blotting were employed for determining expression of miR-128, JAG1, Bax and Bcl-2. MTT assay, Giemsa staining and flow cytometry were applied to detect DDP resistance, cellular morphology and cell cycle respectively...
November 1, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29089371/fxr-tgr5-dual-agonist-prevents-progression-of-nephropathy-in-diabetes-and-obesity
#19
Xiaoxin X Wang, Dong Wang, Yuhuan Luo, Komuraiah Myakala, Evgenia Dobrinskikh, Avi Z Rosenberg, Jonathan Levi, Jeffrey B Kopp, Amanda Field, Ashley Hill, Scott Lucia, Liru Qiu, Tao Jiang, Yingqiong Peng, David Orlicky, Gabriel Garcia, Michal Herman-Edelstein, Vivette D'Agati, Kammi Henriksen, Luciano Adorini, Mark Pruzanski, Cen Xie, Kristopher W Krausz, Frank J Gonzalez, Suman Ranjit, Alexander Dvornikov, Enrico Gratton, Moshe Levi
Bile acids are ligands for the nuclear hormone receptor farnesoid X receptor (FXR) and the G protein-coupled receptor TGR5. We have shown that FXR and TGR5 have renoprotective roles in diabetes- and obesity-related kidney disease. Here, we determined whether these effects are mediated through differential or synergistic signaling pathways. We administered the FXR/TGR5 dual agonist INT-767 to DBA/2J mice with streptozotocin-induced diabetes, db/db mice with type 2 diabetes, and C57BL/6J mice with high-fat diet-induced obesity...
October 31, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29084166/determination-of-verapamil-hcl-in-pharmaceutical-preparations-by-a-fluorescent-nano-probe-based-on-cdte-cds-zns-quantum-dots
#20
Sohail Muhammad, Guanhong Xu, Fangdi Wei, Yujie Ma, Yunsu Ma, Yueyue Song, Menglan Shi, Xiaoman Xu, Yao Cen, Qin Hu
An analytical technique based on fluorescence quenching of CdTe/CdS/ZnS quantum dots (QDs) was developed to quantify verapamil in commercially available preparations. Various reaction parameters were optimized and the method developed was validated. One way analysis of variance (ANOVA) and post hoc tests at a 5% significance level were performed to justify the significance of the variation in observations. The linear range of the verapamil concentration was 0.25-5 µg/mL while the limit of detection was 20 µg/mL...
October 30, 2017: Nanomaterials
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