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Charles M Luft, Elango Munusamy, Jeanne E Pemberton, Steven D Schwartz
A detailed molecular dynamics simulation study is presented on the behavior of aggre- gates composed of the nonionic monorhamnolipid α-rhamnopyranosyl-β-hydroxydecanoyl- β -hydroxydecanoate (Rha-C10-C10) and decane in bulk water. A graph theoretical approach was utilized to characterize the size and composition of the many aggregates generated in our simulations. Overall we observe that the formation of oil in Rha-C10-C10 aggregates is a fa- vorable process. Detailed analysis on the surfactant/oil aggregate shows that larger aggregates are stable...
March 16, 2018: Journal of Physical Chemistry. B
Longchao Yao, Jun Chen, Paul E Sojka, Xuecheng Wu, Kefa Cen
Dynamic stringy objects such as liquid rims and ligaments are frequently observed in important applications such as the multiphase breakup of fuel droplets. We develop a new method based on digital in-line holography to automatically measure complicated stringy objects. A static spring mounted on a rotator is measured to validate the effectiveness and accuracy of the method. The sections are extracted along the skeleton of the spring in a depth-of-field extended image and then sized and located as individual particles using a hybrid method...
March 15, 2018: Optics Letters
J B Albert, G Anton, I Badhrees, P S Barbeau, R Bayerlein, D Beck, V Belov, M Breidenbach, T Brunner, G F Cao, W R Cen, C Chambers, B Cleveland, M Coon, A Craycraft, W Cree, T Daniels, M Danilov, S J Daugherty, J Daughhetee, J Davis, S Delaquis, A Der Mesrobian-Kabakian, R DeVoe, T Didberidze, J Dilling, A Dolgolenko, M J Dolinski, W Fairbank, J Farine, S Feyzbakhsh, P Fierlinger, D Fudenberg, R Gornea, K Graham, G Gratta, C Hall, E V Hansen, J Hoessl, P Hufschmidt, M Hughes, A Jamil, M J Jewell, A Johnson, S Johnston, A Karelin, L J Kaufman, T Koffas, S Kravitz, R Krücken, A Kuchenkov, K S Kumar, Y Lan, D S Leonard, G S Li, S Li, C Licciardi, Y H Lin, R MacLellan, T Michel, B Mong, D Moore, K Murray, R Nelson, O Njoya, A Odian, I Ostrovskiy, A Piepke, A Pocar, F Retière, P C Rowson, J J Russell, S Schmidt, A Schubert, D Sinclair, V Stekhanov, M Tarka, T Tolba, R Tsang, P Vogel, J-L Vuilleumier, M Wagenpfeil, A Waite, T Walton, M Weber, L J Wen, U Wichoski, G Wrede, L Yang, Y-R Yen, O Ya Zeldovich, J Zettlemoyer, T Ziegler
Results from a search for neutrinoless double-beta decay (0νββ) of ^{136}Xe are presented using the first year of data taken with the upgraded EXO-200 detector. Relative to previous searches by EXO-200, the energy resolution of the detector has been improved to σ/E=1.23%, the electric field in the drift region has been raised by 50%, and a system to suppress radon in the volume between the cryostat and lead shielding has been implemented. In addition, analysis techniques that improve topological discrimination between 0νββ and background events have been developed...
February 16, 2018: Physical Review Letters
Shaoyi Cai, Gengzheng Zhu, Xiaohong Cen, Jingjie Bi, Jingru Zhang, Xiaoshan Tang, Kun Chen, Kui Cheng
Toll-like receptor 2 (TLR2) can recognize pathogen-associated molecular patterns to defense against invading organisms and has been represents an attractive therapeutic target. Until today, none TLR2 small molecule antagonist have been developed in clinical trial. Herein, we designed and synthesized 50 N-benzylideneaniline compounds with the help of CADD. And subsequent in vitro studies leading to the optimized compound SMU-A0B13 with most potent inhibitory activity to TLR2 (IC50 =18.21 ± 0.87 μM)...
March 10, 2018: Bioorganic & Medicinal Chemistry
Wen-Tai Chiu, Heng-Ai Chang, Yi-Hsin Lin, Yu-Shan Lin, Hsiao-Tzu Chang, Hsi-Hui Lin, Soon-Cen Huang, Ming-Jer Tang, Meng-Ru Shen
Ca2+ plays a significant role in linking the induction of apoptosis. The key anti-apoptotic protein, Bcl-2, has been reported to regulate the movement of Ca2+ across the ER membrane, but the exact effect of Bcl-2 on Ca2+ levels remains controversial. Store-operated Ca2+ entry (SOCE), a major mode of Ca2+ uptake in non-excitable cells, is activated by depletion of Ca2+ in the ER. Depletion of Ca2+ in the ER causes translocation of the SOC channel activator, STIM1, to the plasma membrane. Thereafter, STIM1 binds to Orai1 or/and TRPC1 channels, forcing them to open and thereby allow Ca2+ entry...
December 2018: Cell Death Discovery
Xinqi Huang, Xiao Cen, Jun Liu
BACKGROUND: The aim of this study was to assess the influence of protraction facemask (PFM) on temporomandibular joint (TMJ) of skeletal Class III malocclusion patients. METHOD: Literature searches were carried out electronically in five English and three Chinese databases (Cochrane Database of Systematic Reviews, the Cochrane Central Register of Controlled Trials, PubMed, Embase, MEDLINE (via Ovid), Chinese Biomedical Literature Database, China National Knowledge Infrastructure, and VIP Database)...
March 12, 2018: BMC Oral Health
Cen Zhang, John A Detre, Scott E Kasner, Brett Cucchiara
Objective: The objective of this study is to determine whether structural features of the vertebrobasilar arterial system are related to migraine. Background: Alterations in cerebral vascular structure and function have been associated with migraine, possibly mediated by hypoperfusion and/or endothelial dysfunction triggering cortical spreading depression. Vessel tortuosity, in particular, has been associated with both altered hemodynamics and endothelial function...
2018: Frontiers in Neurology
Ye Zhang, April Z Gu, Tianyu Cen, Xiangyang Li, Dan Li, Jianmin Chen
Particles exhausted from petrol and diesel consumptions are major components of urban air pollution that can be exposed to human via direct inhalation or other routes due to atmospheric deposition into water and soil. Antimicrobial resistance is one of the most serious threats to modern health care. However, how the petrol and diesel exhaust particles affect the development and spread of antimicrobial resistance genes (ARGs) in various environments remain largely unknown. This study investigated the effects and potential mechanisms of four representative petrol and diesel exhaust particles, namely 97 octane petrol, 93 octane petrol, light diesel oil, and marine heavy diesel oil, on the horizontal transfer of ARGs between two opportunistic Escherichia coli (E...
March 7, 2018: Environment International
Oliver G Bosch, Fabrizio Esposito, Dario Dornbierer, Michael M Havranek, Robin von Rotz, Michael Kometer, Philipp Staempfli, Boris B Quednow, Erich Seifritz
According to the triple network hypothesis the brain is equipped with three core neurocognitive networks: the default mode (DMN), the salience (SN), and the central executive (CEN) network. Moreover, the so called dorsal nexus, has met growing interest as it is a hub region connecting these three networks. Assessment of resting-state functional connectivity (rsFC) of these networks enables the elucidation of drug-induced brain alterations. Gamma-hydroxybutyrate (GHB) is a GHB/GABA-B receptor agonist that induces a paradoxical state of mixed stimulation and sedation at moderate doses, which makes it a valuable tool to investigate neural signatures of subjective drug effects...
March 7, 2018: NeuroImage
Longbo Zheng, Ming Xu, Junjie Xu, Ke Wu, Qian Fang, Yuelong Liang, Senjun Zhou, Dong Cen, Lin Ji, Weili Han, Xiujun Cai
Hepatocellular carcinoma (HCC) is one of the most common malignant cancers and currently the third leading cause of cancer-related deaths, worldwide. Epithelial-mesenchymal transition (EMT) plays a major role in HCC progression. In this study, we first found that the expression of E74-like ETS transcription factor 3 (ELF3), a member of the E-twenty-six family of transcription factors, was increased in HCC tissues, and that ELF3 overexpression was associated with poor prognoses for HCC patients. Gain-of-function and loss-of-function studies revealed that increased ELF3 expression promoted HCC cell proliferation, migration, and invasion, while these processes were inhibited when ELF3 was silenced...
March 9, 2018: Cell Death & Disease
Xiaofeng Xie, Zhu Liang Yu, Zhenghui Gu, Jun Zhang, Ling Cen, Yuanqing Li
In off-line training of motor imagery-based brain-computer interfaces (BCIs), to enhance the generalization performance of the learned classifier, the local information contained in test data could be used to improve the performance of motor imagery as well. Further considering that the covariance matrices of electroencephalogram (EEG) signal lie on Riemannian manifold, in this paper, we construct a Riemannian graph to incorporate the information of training and test data into processing. The adjacency and weight in Riemannian graph are determined by the geodesic distance of Riemannian manifold...
March 2018: IEEE Transactions on Neural Systems and Rehabilitation Engineering
Ji-Ming Wang, Er-Li Ma, Qing-Ping Wu, Ming Tian, Yan-Yan Sun, Jing Lin, Liang Peng, Qiang Xu, Wei Wei, Hong Tan, Cen Yang, Xiao-Qiang Li, Yun-Xia Zuo, Jin Liu
Background: Patients with potential difficult mask ventilation (DV) and difficult intubation (DI) are often managed with awake intubation, which can be stressful for patients and anesthesiologists. This prospective randomized study evaluated a new approach, fast difficult airway evaluation (FDAE). We hypothesized that the FDAE approach would reduce the need for awake intubation. Methods: After obtaining informed consent, 302 patients with potential DV/DI undergoing elective surgeries were randomly assigned to the FDAE group (Group E) and the control group (Group C)...
March 20, 2018: Chinese Medical Journal
Li Wen, Ye-Fang Liu, Cen Jiang, Shao-Qian Zeng, Yue Su, Wen-Jun Wu, Xi-Yang Liu, Jian Wang, Ying Liu, Chen Su, Bai-Xue Li, Quan-Sheng Feng
Given the challenges in exploring lifelong therapy with little side effect for human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) cases, there is increasing interest in developing traditional Chinese medicine (TCM) treatments based on specific TCM syndrome. However, there are few objective and biological evidences for classification and diagnosis of HIV/AIDS TCM syndromes to date. In this study, iTRAQ-2DLC-MS/MS coupled with bioinformatics were firstly employed for comparative proteomic profiling of top popular TCM syndromes of HIV/AIDS: accumulation of heat-toxicity (AHT) and Yang deficiency of spleen and kidney (YDSK)...
March 8, 2018: Scientific Reports
Eric Poliner, Tomomi Takeuchi, Zhi-Yan Du, Christoph Benning, Eva Farre
Utilization of microalgae has been hampered by limited tools for creating loss-of-function mutants. Furthermore, modified strains for deployment into the field must be free of antibiotic resistance genes and face fewer regulatory hurdles if they are transgene free. The oleaginous microalga, Nannochloropsis oceanica CCMP1779, is an emerging model for microalga lipid metabolism. We present a one-vector episomal CRISPR/Cas9 system for N. oceanica that enables the generation of marker-free mutant lines. The CEN/ARS6 region from Saccharomyces cerevisiae was included in the vector to facilitate its maintenance as circular extrachromosal DNA...
March 8, 2018: ACS Synthetic Biology
Yun-Zhu Mu, Zi-Cen Du, Zheng-Zhong Zhang, Hao Yang, Xing Chen, Yanbo Wang, Lin-Li Liu
Distrophic epidermolysis bullosa pruriginosa(DEB-Pr, OMIM#604129) is a rare subtype of epidermolysis bullosa dystrophica. It is characterized by recurrent vesicles and erosions on the extensor of the limbs at birth or shortly thereafter and pruriginosa papules and nodules accompanied with intense itching and nail dystrophy in adult stage1 . Histology reveals hyperkeratosis, mild acanthosis and a subepidermal blister formation2 . Electron microscopic studies showed alterations in the number and ultrastructure of anchoring fibrils in lesional, perilesional and non-lesional skin3 ...
March 6, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Meng Wu, Jun-Jie Shi, Min Zhang, Yi-Min Ding, Hui Wang, Yu-Lang Cen, Wen-Hui Guo, Shu-Hang Pan, Yao-Hui Zhu
Quite recently, two-dimensional (2D) InSe nanosheet becomes a hot material with great promise for advanced functional nano-devices. In this work, for the first time, we perform first-principles calculations on the structural, electronic, magnetic and transport properties of 1D InSe nanoribbons with/without hydrogen or halogen saturation. We find that the armchair ribbons, with different edges and distortions, are all nonmagnetic semiconductors with a direct bandgap of 1.3 (1.4) eV for the bared (H-saturated) ribbons and hold the high electron mobility about 10<sup>3</sup> cm<sup>2</sup>V<sup>-1</sup>s<sup>-1</sup>, as the 2D InSe nanosheet...
March 5, 2018: Nanotechnology
Zijin Liu, Gang Li, Cheng Long, Jing Xu, Juren Cen, Xiaobo Yang
The antioxidant activity and genotoxicity of isogarcinol were assessed by several in vitro tests. Its IC50 values for DPPH and ABTS were 36.3 ± 3.35 µM and 16.6 ± 3.98 µM, respectively, which were all lower than those of VC and BHT. Isogarcinol had no cyctotoxic or promotional activities at 1-10 µM in the CCK-8 assay, and negligible genotoxic effects at 50-500 µM on HepG2 cells by the single-cell gel electrophoresis assay. Pre-incubation of the cells with 0.5-1.5 µM isogarcinol, before exposure to H2 O2 , significantly increased cell viability in a concentration-dependent manner...
July 1, 2018: Food Chemistry
Cen Meng, Huanyao Liu, Yi Wang, Yuyuan Li, Jiaogen Zhou, Ping Zhou, Xinliang Liu, Yong Li, Jinshui Wu
Exploring the relationship between net anthropogenic phosphorus input (NAPI) and soil available P (SAP) content could inform applied issues related to environmental quality and agronomic productivity and increase our knowledge of element biogeochemical cycles. Here, the NAPI was estimated and the SAP content determined in eight counties in subtropical China from 1980 to 2010. It is suggested that the NAPI ranging 318-924 km-2  yr-1 in 1980 had increased substantially to 865-3601 km-2  yr-1 in 2010 across the eight counties, in which the P fertilizer application was estimated to represent the largest individual source of NAPI, accounting for an average of 36...
February 22, 2018: Chemosphere
Jessika Nystedt, Peter Mannfolk, Petra Nilsson, Anders Bengtsson, Andreas Jönsen, Pia C Sundgren, Olof Strandberg
PURPOSE: To investigate resting state functional connectivity of lupus-patients and associated subgroups according to the ACR NPSLE case definitions (ACR ad Hoc 1999). Additionally, we investigated whether or not the observed alterations correlated with disease duration, SLE-disease activity index-2000 (SLEDAI-2k) and Systemic Lupus International Collaborating Clinical/ACR organ damage index (SDI)-scores. MATERIAL AND METHOD: Anatomical 3T MRI and resting state-fMRI (rs-fMRI) were performed in 61 female lupus-patients (mean age = 37...
March 2, 2018: Brain Connectivity
Xiaodan Zhang, Yange Yu, Yesheng Cen, Dongfeng Yang, Zhechen Qi, Zhuoni Hou, Shuanglai Han, Zengxuan Cai, Kuancheng Liu
To better understand the mechanisms underlying the pharmacological actions of Salvia miltiorrhiza , correlation between the chemical profiles and in vitro antioxidant activities in 50 batches of wild S. miltiorrhiza samples was analyzed. Our ultra-performance liquid chromatography-tandem mass spectrometry analysis detected twelve phenolic acids and five tanshinones and obtained various chemical profiles from different origins. In a principal component analysis (PCA) and cluster analysis, the tanshinones cryptotanshinone, tanshinone IIA and dihydrotanshinone I exhibited higher weights in PC1, whereas the phenolic acids danshensu, salvianolic acids A and B and lithospermic acid were highly loaded in PC2...
February 28, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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