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https://www.readbyqxmd.com/read/28926724/in-situ-grafting-to-improve-polarity-of-polyacrylonitrile-hollow-fiber-supported-polydimethylsiloxane-membranes-for-co2-separation
#1
Leiqing Hu, Jun Cheng, Yannan Li, Jianzhong Liu, Junhu Zhou, Kefa Cen
Surface grafting modification was proposed to improve the surface polarity of polyacrylonitrile hollow fiber-supported polydimethylsiloxane (PDMS) membrane. The initiator 3-aminopropyltriethoxysilane containing one amine group was integrated into PDMS, and polyvinyl pyrrolidone (PVP) with strong polarity was connected to the surface by reacting with amine groups. Surface grafting modification was proven on X-ray photoelectron spectroscopy. The sharp decrease (from ∼98° to ∼28°) in water contact angle of the PDMS membrane indicated the significant improvement in surface polarity after the modification...
September 14, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28925718/interaction-analysis-between-blk-rs13277113-polymorphism-and-bank1-rs3733197-polymorphism-mmel1-tnfrsf14-rs3890745-polymorphism-in-determining-susceptibility-to-rheumatoid-arthritis
#2
Hua Huang, Si-Chao Huang, Dong-Jin Hua, Qing-Qing Sun, Han Cen, Xia-Fei Xin
Two pairwise genetic interactions (B cell lymphocyte kinase (BLK) rs13277113,B cell scaffold protein with ankyrin repeats 1 (BANK1) rs3733197and BLK rs13277113 membrane metalloendopeptidase like 1 (MMEL1)/ tumor necrosis factor receptor superfamily member 14 (TNFRSF14) rs3890745) have been demonstrated in determining susceptibility to rheumatoid arthritis (RA) without replication, thus this study was performed to examine whether abovementioned genetic polymorphisms were associated with RA and further tests were performed to see whether aforementioned genetic interactions existed in RA among Chinese population...
September 19, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28924828/a-network-based-neurobiological-model-of-ptsd-evidence-from-structural-and-functional-neuroimaging-studies
#3
REVIEW
Teddy J Akiki, Christopher L Averill, Chadi G Abdallah
PURPOSE OF REVIEW: Although a fine-grained understanding of the neurobiology of posttraumatic stress disorder (PTSD) is yet to be elucidated, the last two decades have seen a rapid growth in the study of PTSD using neuroimaging techniques. The current review summarizes important findings from functional and structural neuroimaging studies of PTSD, by primarily focusing on their relevance towards an emerging network-based neurobiological model of the disorder. RECENT FINDINGS: PTSD may be characterized by a weakly connected and hypoactive default mode network (DMN) and central executive network (CEN) that are putatively destabilized by an overactive and hyperconnected salience network (SN), which appears to have a low threshold for perceived saliency, and inefficient DMN-CEN modulation...
September 19, 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28924551/identification-and-characterization-of-loop7-motif-and-its-role-in-regulating-biological-function-of-human-apobec3g-through-molecular-modeling-and-biological-assay
#4
Congjie Zhai, Ling Ma, Zhixin Zhang, Jiwei Ding, Jing Wang, Yongxin Zhang, Xiaoyu Li, Fei Guo, Liyan Yu, Jinming Zhou, Shan Cen
Human APOBEC3G (hA3G) is a cytidine deaminase which inhibits HIV-1 replication. The HIV-1 accessory protein viral infectivity factor (Vif) counteracts with hA3G by targeting it for proteasomal degradation. In this work, we constructed and optimized molecular models of the hA3G dimer and the hA3G-Vif complex. The molecular modeling study revealed that the loop7 motif of hA3G appears on the interfaces of both the hA3G-Vif complex and the hA3G dimer. Biochemical analysis provided evidence suggesting that binding of Vif to hA3G results in steric blocking of hA3G dimerization, implying that monomeric hA3G serves as a substrate for Vif-mediated degradation...
September 2017: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/28918936/intermittent-fasting-promotes-white-adipose-browning-and-decreases-obesity-by-shaping-the-gut%C3%A2-microbiota
#5
Guolin Li, Cen Xie, Siyu Lu, Robert G Nichols, Yuan Tian, Licen Li, Daxeshkumar Patel, Yinyan Ma, Chad N Brocker, Tingting Yan, Kristopher W Krausz, Rong Xiang, Oksana Gavrilova, Andrew D Patterson, Frank J Gonzalez
While activation of beige thermogenesis is a promising approach for treatment of obesity-associated diseases, there are currently no known pharmacological means of inducing beiging in humans. Intermittent fasting is an effective and natural strategy for weight control, but the mechanism for its efficacy is poorly understood. Here, we show that an every-other-day fasting (EODF) regimen selectively stimulates beige fat development within white adipose tissue and dramatically ameliorates obesity, insulin resistance, and hepatic steatosis...
September 13, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28917128/application-of-ultra-high-performance-liquid-chromatography-coupled-with-ltq-orbitrap-mass-spectrometry-for-identification-confirmation-and-quantitation-of-illegal-adulterated-weight-loss-drugs-in-plant-dietary-supplements
#6
Qiaoyuan Cheng, Linjun Shou, Cen Chen, Shi Shi, Minghao Zhou
In this paper, an ultra-high-performance liquid chromatography coupled with linear ion trap quadrupole Orbitrap high resolution mass spectrometry (UHPLC-LTQ-Orbitrap HRMS) method was developed and validated for identification, confirmation and quantitation of illegal adulterated weight-loss drugs in plant dietary supplements. 13 wt-loss drugs were well separated by the gradient elution of 10mmol/L ammonium acetate - 0.05% formic acid H2O and acetonitrile at a flow rate of 0.2mL/min within 12min. The MS analysis was operated under the positive ion and in full MS/dd-MS(2) (data-dependent MS(2)) mode...
September 9, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28900617/serum-and-brain-metabolomic-variations-reveal-perturbation-of-sleep-deprivation-on-rats-and-ameliorate-effect-of-total-ginsenoside-treatment
#7
Xiao-Jun Gou, Fang Cen, Zi-Quan Fan, Ying Xu, Hong-Yi Shen, Ming-Mei Zhou
Sleep loss or sleep deprivation (SD) refers to shorter sleep than average baseline need, and SD has been a serious problem of modern societies which affects health and well-being. Panax ginseng is a well-known traditional Chinese medicine (TCM). Our previous study has demonstrated that total ginsenosides (GS), the extracts from Panax ginseng, could effectively improve cognition and behavior on SD rats. However, little is known about its metabolomic study. In this study, serum and brain metabolomic method based on gas chromatography coupled with mass spectrometry (GC/MS) was employed to evaluate the efficacy and study the mechanism of GS on a rat model of SD...
2017: International Journal of Genomics
https://www.readbyqxmd.com/read/28900440/chlorophyll-fluorescence-imaging-uncovers-photosynthetic-fingerprint-of-citrus-huanglongbing
#8
Haiyan Cen, Haiyong Weng, Jieni Yao, Mubin He, Jingwen Lv, Shijia Hua, Hongye Li, Yong He
Huanglongbing (HLB) is one of the most destructive diseases of citrus, which has posed a serious threat to the global citrus production. This research was aimed to explore the use of chlorophyll fluorescence imaging combined with feature selection to characterize and detect the HLB disease. Chlorophyll fluorescence images of citrus leaf samples were measured by an in-house chlorophyll fluorescence imaging system. The commonly used chlorophyll fluorescence parameters provided the first screening of HLB disease...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28900396/corrigendum-conversion-discriminative-analysis-on-mild-cognitive-impairment-using-multiple-cortical-features-from-mr-images
#9
Shengwen Guo, Chunren Lai, Congling Wu, Guiyin Cen
[This corrects the article on p. 146 in vol. 9, PMID: 28572766.].
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28891564/standardisation-of-a-european-measurement-method-for-organic-carbon-and-elemental-carbon-in-ambient-air-results-of-the-field-trial-campaign-and-the-determination-of-a-measurement-uncertainty-and-working-range
#10
Richard J C Brown, Sonya Beccaceci, David M Butterfield, Paul G Quincey, Peter M Harris, Thomas Maggos, Pavlos Panteliadis, Astrid John, Aleksandra Jedynska, Thomas A J Kuhlbusch, Jean-Philippe Putaud, Angeliki Karanasiou
The European Committee for Standardisation (CEN) Technical Committee 264 'Air Quality' has recently produced a standard method for the measurements of organic carbon and elemental carbon in PM2.5 within its working group 35 in response to the requirements of European Directive 2008/50/EC. It is expected that this method will be used in future by all Member States making measurements of the carbonaceous content of PM2.5. This paper details the results of a laboratory and field measurement campaign and the statistical analysis performed to validate the standard method, assess its uncertainty and define its working range to provide clarity and confidence in the underpinning science for future users of the method...
September 11, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/28889600/normothermic-ex-vivo-kidney-perfusion-for-graft-quality-assessment-prior-to-transplantation
#11
J Moritz Kaths, Mátyás Hamar, Juan Echeverri, Ivan Linares, Peter Urbanellis, Jun Yu Cen, Sujani Ganesh, Luke S Dingwell, Paul Yip, Rohan John, Darius Bagli, Istvan Mucsi, Anand Ghanekar, David Grant, Lisa A Robinson, Markus Selzner
Normothermic ex vivo kidney perfusion (NEVKP) represents a novel approach for graft preservation and functional improvement in kidney transplantation. We investigated whether NEVKP also allows graft quality assessment prior to transplantation. Kidneys from 30kg pigs were recovered in a model of heart-beating donation (HBD) (group A), following 30min of warm ischemia (WI) (group B), or 60min WI (group C) (n=5/group). Following 8hrs of NEVKP, contralateral kidneys were resected, grafts autotransplanted, and pigs followed for 3 days...
September 10, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28885495/isoglycyrrhizinate-magnesium-enhances-hepatoprotective-effect-of-fk506-on-ischemia-reperfusion-injury-through-hmgb1-inhibition-in-a-rat-model-of-liver-transplantation
#12
Zhang Weichen, Li Feibo, Ye Yufu, Liu Yuanxing, Yu Songfeng, Cen Chao, Chen Xuliang, Zhou Lin, Tang Xiaofeng, Yu Jun, Zheng Shusen
BACKGROUND: Ischemia-reperfusion injury (IRI) after liver transplantation impairs graft function and affects prognosis of recipients. Isoglycyrrhizinate magnesium (Iso) is a hepatoprotective drug usually used after liver injury. In this study, we intended to explore whether Iso alone have protective effect after IRI in a rat model of liver transplantataion. We also aimed to study whether Iso could enhance the hepatoprotective effect of FK506 (tacrolimus) and underlying mechanism. METHODS: Rats after liver transplantation were treated with different concentration of FK506 with or without, Iso or lower-dose FK506 plus Iso...
September 6, 2017: Transplantation
https://www.readbyqxmd.com/read/28885267/bcl-2-and-bcl-xl-mediate-resistance-to-receptor-tyrosine-kinase-targeted-therapy-in-lung-and-gastric-cancer
#13
Junfei Jin, Ying Xiong, Bo Cen
Promising clinical efficacy has been observed with receptor tyrosine kinase inhibitors (TKIs) particularly in lung and gastric cancers with mutations or amplifications in the targeted receptor tyrosine kinases (RTKs). However, the efficacy and the duration of the response to these inhibitors are limited by the emergence of drug resistance. Here, we report treatment of RTK-dependent lung and gastric cancer cell lines with TKIs increased protein levels of Bcl-2 and Bcl-xL. The combination of the Bcl-2 and Bcl-xL inhibitor ABT-263 and TKIs was superior to TKIs alone in reducing cell viability and capacity of resistant colony formation...
September 6, 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28878188/mtld-a-database-of-multiple-target-ligands-the-updated-version
#14
Chao Chen, Meng Wu, Shan Cen, Jianhui Wu, Jinming Zhou
Polypharmacology plays an important role in drug discovery and polypharmacology drug strategies provide a novel path in drug design. However, to develop a polypharmacology drug with the desired profile remains a challenge. Previously, we developed a free web-accessible database called Multiple Target Ligand Database (MTLD, www.mtdcadd.com). Herein, the MTLD database has been updated, containing 2444 Multiple Target Ligands (MTLs) that bind with 21,424 binding sites from 18,231 crystal structures. Of the MTLs, 304 entries are approved drugs, and 1911 entries are drug-like compounds...
September 6, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28876887/a-ratiometric-fluorescence-universal-platform-based-on-n-cu-codoped-carbon-dots-to-detect-metabolites-participating-in-h2o2-generation-reactions
#15
Yunsu Ma, Yao Cen, Muhammad Sohail, Guanhong Xu, Fangdi Wei, Menglan Shi, Xiaoman Xu, Yueyue Song, Yujie Ma, Qin Hu
In this work, a new kind of N, Cu codoped carbon dots (N/Cu-CDs) was prepared via a facile one-pot hydrothermal method by using citric acid monohydrate, copper acetate monohydrate and diethylenetriamine. The prepared N/Cu-CDs with a high quantum yield (50.1%) showed excitation-independent emission at 460 nm. The structure and fluorescence properties of N/Cu-CDs were characterized by high-resolution transmission electron microscopy, fluorescence spectrofluorometer, FT-IR spectrometer, UV-visible spectrophotometer and X-ray photoelectron spectroscopy...
September 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28873459/divergent-lysm-effectors-contribute-to-the-virulence-of-beauveria-bassiana-by-evasion-of-insect-immune-defenses
#16
Kai Cen, Bing Li, Yuzhen Lu, Siwei Zhang, Chengshu Wang
The lysin motif (LysM) containing proteins can bind chitin and are ubiquitous in various organisms including fungi. In plant pathogenic fungi, a few LysM proteins have been characterized as effectors to suppress chitin-induced immunity in plant hosts and therefore contribute to fungal virulence. The effector mechanism is still questioned in fungus-animal interactions. In this study, we found that LysM proteins are also present in animal pathogenic fungi and have evolved divergently. The genome of the insect pathogen Beauveria bassiana encodes 12 LysM proteins, and the genes were differentially transcribed by the fungus when grown in different conditions...
September 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28872842/core-shell-shell-multifunctional-nanoplatform-for-intracellular-tumor-related-mrnas-imaging-and-near-infrared-light-triggered-photodynamic-photothermal-synergistic-therapy
#17
Yao Cen, Wen-Jing Deng, Yuan Yang, Ru-Qin Yu, Xia Chu
A multifunctional nanoplatform, which generally integrates biosensing, imaging diagnosis, and therapeutic functions into a single nanoconstruct, has great important significance for biomedicine and nanoscience. Here, we developed a core-shell-shell multifunctional polydopamine (PDA) modified upconversion nanoplatform for intracellular tumor-related mRNAs detection and near-infrared (NIR) light triggered photodynamic and photothermal synergistic therapy (PDT-PTT). The nanoplatform was constructed by loading a silica shell on the hydrophobic upconversion nanoparticles (UCNPs) with hydrophilic photosensitizer methylene blue (MB) entrapped in it, and then modifying PDA shells through an in situ self-polymerization process, thus yielding a core-shell-shell nanoconstruct UCNP@SiO2-MB@PDA...
September 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28864167/a-review-of-cinnabar-hgs-and-or-realgar-as4s4-containing-traditional-medicines
#18
REVIEW
Jie Liu, Li-Xin Wei, Qi Wang, Yuan-Fu Lu, Feng Zhang, Jing-Zhen Shi, Cen Li, M George Cherian
ETHNOPHARMOCOLOGICAL RELEVANCE: Herbo-metallic preparations have a long history in the treatment of diseases, and are still used today for refractory diseases, as adjuncts to standard therapy, or for economic reasons in developing countries. AIM OF THE REVIEW: This review uses cinnabar (HgS) and realgar (As4S4) as mineral examples to discuss their occurrence, therapeutic use, pharmacology, toxicity in traditional medicine mixtures, and research perspectives. MATERIALS AND METHODS: A literature search on cinnabar and realgar from PubMed, Chinese pharmacopeia, Google and other sources was carried out...
August 31, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28862770/glucosamine-oral-administration-as-an-adjunct-to-hyaluronic-acid-injection-in-treating-temporomandibular-joint-osteoarthritis
#19
Xiao Cen, Yan Liu, Shasha Wang, Xianrui Yang, Zongdao Shi, Xinhua Liang
OBJECTIVE: To investigate the therapeutic effect of oral glucosamine (GS) as an adjunct to hyaluronic acid (HA) injection on patients with temporomandibular joint osteoarthritis (TMJ OA). METHODS: In this clinical trial, 136 participants, diagnosed as TMJ OA clinically and radiographically, were enrolled and randomized into two groups (Group GS+HA: oral GS+HA injection; Group placebo+HA: oral placebo+HA injection). Pain, maximum inter-incisal mouth opening (MMO), the levels of IL-1β, IL-6, and TGF-β in TMJ synovial were defined as the outcome measurements and conducted before operation, and at 1-month, 1-year follow-up...
September 1, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28860662/analyses-of-mitogenome-sequences-revealed-that-asian-citrus-psyllids-diaphorina-citri-from-california-were-related-to-those-from-florida
#20
Fengnian Wu, Luci Kumagai, Yijing Cen, Jianchi Chen, Christopher M Wallis, MaryLou Polek, Hongyan Jiang, Zheng Zheng, Guangwen Liang, Xiaoling Deng
Asian citrus psyllid (ACP, Diaphorina citri Kuwayama) transmits "Candidatus Liberibacter asiaticus" (CLas), an unculturable alpha-proteobacterium associated with citrus Huanglongbing (HLB). CLas has recently been found in California. Understanding ACP population diversity is necessary for HLB regulatory practices aimed at reducing CLas spread. In this study, two circular ACP mitogenome sequences from California (mt-CApsy, ~15,027 bp) and Florida (mt-FLpsy, ~15,012 bp), USA, were acquired. Each mitogenome contained 13 protein coding genes, 2 ribosomal RNA and 22 transfer RNA genes, and a control region varying in sizes...
August 31, 2017: Scientific Reports
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