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https://www.readbyqxmd.com/read/28535418/a-study-of-peritoneal-metastatic-xenograft-model-of-colorectal-cancer-in-the-treatment-of-hyperthermic-intraperitoneal-chemotherapy-with-raltitrexed
#1
Cen Qiu, Yueqi Li, Xin Liang, Yingxue Qi, Yiyang Chen, Xianke Meng, Hongtu Zheng, Ye Xu, Sanjun Cai, Guoxiang Cai, Jianwen Liu
Peritoneal metastasis of colorectal cancer is one of the most incident and fateful diseases among relapse cases. It shows a certain resistance to systemic chemotherapy. The perfusion system in clinic is complex and hard to be used in fundamental researches. This study aims at evaluating the effect of an improved hyperthermic intraperitoneal chemotherapy with Raltitrexed used in tumor-bearing mice with peritoneal metastatic colorectal carcinoma. The results showed that no severe adverse effect was observed. All control animals developed extensive peritoneal and mesenteric metastatic nodes...
May 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28534396/tailoring-active-sites-via-synergy-between-graphitic-and-pyridinic-n-for-the-enhanced-catalytic-efficiency-of-carbocatalyst
#2
Jieyuan Li, Shi Yin, Fan Dong, Wanglai Cen, Yinghao Chu
Due to the limited characterization methods of structures and morphology of N doped carbocatalysts that are available at the atomic level, the detailed promotion mechanism of the catalytic efficiency is unspecific and the particular active sites introduced by the N atoms require further evaluation. Herein, this challenging issue is tackled by extensive theoretical simulation. It is firstly proposed that the active sites, where O2 molecules become adsorbed and activated, are tailored by synergistic graphitic and pyridinic N atoms, which remarkably accelerate the generation of highly chemical reactive O-containing species...
May 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28533068/in-vivo-kinetics-of-lipids-and-astaxanthin-evolution-in-haematococcus-pluvialis-mutant-under-15-co2-using-raman-microspectroscopy
#3
Ke Li, Jun Cheng, Qing Ye, Yong He, Junhu Zhou, Kefa Cen
In vivo spatiotemporal dynamics of lipids and astaxanthin evolution in Haematococcus pluvialis mutant induced with 15% CO2 and high light intensity were monitored with high spatial resolution in a non-destructive and label-free manner using single-cell Raman imaging. Astaxanthin intensity increased by 3.5 times within 12h under 15% CO2, and the accumulation rate was 5.8 times higher than that under air. Lipids intensity under 15% CO2 was 27% higher than that under air. The lipids initially concentrated in chloroplast under 15% CO2 due to an increase of directly photosynthetic fatty acid, which was different from the whole-cell dispersed lipids under air...
May 4, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28531860/boosting-biomethane-yield-and-production-rate-with-graphene-the-potential-of-direct-interspecies-electron-transfer-in-anaerobic-digestion
#4
Richen Lin, Jun Cheng, Jiabei Zhang, Junhu Zhou, Kefa Cen, Jerry D Murphy
Interspecies electron transfer between bacteria and archaea plays a vital role in enhancing energy efficiency of anaerobic digestion (AD). Conductive carbon materials (i.e. graphene nanomaterial and activated charcoal) were assessed to enhance AD of ethanol (a key intermediate product after acidogenesis of algae). The addition of graphene (1.0g/L) resulted in the highest biomethane yield (695.0±9.1mL/g) and production rate (95.7±7.6mL/g/d), corresponding to an enhancement of 25.0% in biomethane yield and 19...
May 5, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28523217/relation-between-patterns-of-intrinsic-network-connectivity-cognitive-functioning-and-symptom-presentation-in-trauma-exposed-patients-with-major-depressive-disorder
#5
Melissa Parlar, Maria Densmore, Geoffrey B Hall, Paul A Frewen, Ruth A Lanius, Margaret C McKinnon
OBJECTIVE: The present study investigated resting fMRI connectivity within the default mode (DMN), salience (SN), and central executive (CEN) networks in relation to neurocognitive performance and symptom severity in trauma-exposed patients with major depressive disorder (MDD). METHOD: Group independent component analysis was conducted among patients with MDD (n = 21), examining DMN, SN, and CEN connectivity in relation to neurocognitive performance and symptom severity...
May 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28520815/metabolic-profiling-by-gas-chromatography-mass-spectrometry-of-energy-metabolism-in-high-fat-diet-fed-obese-mice
#6
Daxesh P Patel, Kristopher W Krausz, Cen Xie, Diren Beyoğlu, Frank J Gonzalez, Jeffrey R Idle
A novel, selective and sensitive single-ion monitoring (SIM) gas chromatography-mass spectrometry (GCMS) method was developed and validated for the determination of energy metabolites related to glycolysis, the tricarboxylic acid (TCA) cycle, glutaminolysis, and fatty acid β-oxidation. This assay used N-tert-butyldimethylsilyl-N-methyltrifluoroacetamide (MTBSTFA) containing 1% tert-butyldimethylchlorosilane (TBDMCS) as derivatizing reagent and was highly reproducible, sensitive, specific and robust. The assay was used to analyze liver tissue and serum from C57BL/6N obese mice fed a high-fat diet (HFD) and C57BL/6N mice fed normal chow for 8 weeks...
2017: PloS One
https://www.readbyqxmd.com/read/28515325/mutual-regulation-between-polo-like-kinase-3-and-siah2-e3-ubiquitin-ligase-defines-a-regulatory-network-that-fine-tunes-the-cellular-response-to-hypoxia-and-nickel
#7
Cen Li, Soyoung Park, Xiaowen Zhang, Wei Dai, Dazhong Xu
Elevated cellular response to hypoxia, which contributes to cell transformation and tumor progression, is a prominent feature of malignant cells in solid tumors. Polo-like kinase 3 (Plk3) is a serine/threonine protein kinase known to inhibit the cellular response to hypoxia and tumorigenesis. Nickel compounds are well established human carcinogens that induce tumorigenesis partly through their hypoxia-mimicking effects. Despite the previous research efforts, the role of Plk3 in the hypoxic response induced by hypoxia or nickel is not completely understood...
May 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28511641/network-based-regularization-for-high-dimensional-snp-data-in-the-case-control-study-of-type-2-diabetes
#8
Jie Ren, Tao He, Ye Li, Sai Liu, Yinhao Du, Yu Jiang, Cen Wu
BACKGROUND: Over the past decades, the prevalence of type 2 diabetes mellitus (T2D) has been steadily increasing around the world. Despite large efforts devoted to better understand the genetic basis of the disease, the identified susceptibility loci can only account for a small portion of the T2D heritability. Some of the existing approaches proposed for the high dimensional genetic data from the T2D case-control study are limited by analyzing a few number of SNPs at a time from a large pool of SNPs, by ignoring the correlations among SNPs and by adopting inefficient selection techniques...
May 16, 2017: BMC Genetics
https://www.readbyqxmd.com/read/28511042/controllable-synthesis-of-hierarchical-mnox-tio2-composite-nanofibers-for-complete-oxidation-of-low-concentration-acetone
#9
Xuecheng Zhu, Shuo Zhang, Xinning Yu, Xinbo Zhu, Chenghang Zheng, Xiang Gao, Zhongyang Luo, Kefa Cen
A novel hierarchical MnOx/TiO2 composite nanofiber was fabricated by combining the electrospinning technique and hydrothermal growth method. The synthesized nanomaterial, which comprised primary TiO2 nanofibers and secondary MnOx nanoneedles, was further investigated for complete catalytic oxidation of volatile organic compounds for the first time, and this presented high-oxidation performance on low-concentration acetone. The morphological, structural, physicochemical characterization, and catalytic performance analyses demonstrated that the highest catalytic activity was achieved from the obtained MnOx/TiO2 nanofiber catalyst with 30wt...
April 13, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28511005/characterization-of-l-theanine-excitatory-actions-on-hippocampal-neurons-towards-the-generation-of-novel-n-methyl-d-aspartate-receptor-modulators-based-on-its-backbone
#10
Fatiha Sebih, Matthieu Rousset, Salima Bellahouel, Marc Rolland, Marie Celeste de Jesus Ferreira, Janique Guiramand, Catherine Cohen-Solal, Gérard Barbanel, Thierry Cens, Mohammed Abouazza, Adrien Tassou, Maud Gratuze, Céline Meunier, Pierre Charnet, Michel Vignes, Valérie Rolland
L-Theanine (or L-γ-N-ethyl-glutamine) is the major amino acid found in Camellia sinensis. It has received much attention because of its pleiotropic physiological and pharmacological activities leading to health benefits in humans, especially. We describe here a new, easy, efficient and environmentally-friendly chemical synthesis of L-Theanine and L-γ-N-propyl-Gln and their corresponding D isomers. L-Theanine, and its derivatives obtained so far, exhibited partial co-agonistic action at N-methyl-D-aspartate (NMDA) receptors, with no detectable agonist effect at other glutamate receptors, on cultured hippocampal neurons...
May 16, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28507466/high-level-of-mir-196b-at-newly-diagnosed-pediatric-acute-myeloid-leukemia-predicts-a-poor-outcome
#11
Lihua Xu, Yang Guo, Wenying Yan, Jiannong Cen, Yuna Niu, Qing Yan, Hailong He, Chien-Shing Chen, Shaoyan Hu
Differential expression of microRNAs (miRNAs) has been implicated in leukemogenesis. We investigate the expression pattern of miR-196b. Using quantitative real-time PCR (qRT-PCR), we detected the expression of miR-196b and its correlated genes (SMC1A/MLH1) in initial pediatric AML. A significant association was observed between overexpression of miR-196b and inferior overall survival of pediatric AML (Log Rank P<0.0001). AML M4/5 subtype, high white blood cell (WBC) count at presentation, MLL rearrangement, or FLT3-ITD mutation at diagnosis and non-remission group after the first induction chemotherapy possessed higher miR-196b expression...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28507442/aberrant-promoter-methylation-profiles-and-association-with-survival-in-patients-with-hepatocellular-carcinoma
#12
Dani Zhong, Hong Cen
The aim of this study was to investigate the prognostic and diagnostic value of genes with promoter methylation in hepatocellular carcinoma (HCC) patients. On the basis of The Cancer Genome Atlas data, we identified genes with differentially methylated promoters in HCC tissues and adjacent non-tumor tissues, using the linear models for microarray data approach. Cox proportional hazard regression analysis was applied to access the prognostic value of identified differentially methylated genes. The diagnostic value of the genes was evaluated through receiver operating characteristic...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28505368/farnesoid-x-receptor-protects-against-low-dose-carbon-tetrachloride-induced-liver-injury-through-the-taurocholate-jnk-pathway
#13
Shogo Takahashi, Naoki Tanaka, Srujana Golla, Tatsuki Fukami, Kristopher W Krausz, Marianne A Polunas, Blair C Weig, Yusuke Masuo, Cen Xie, Changtao Jiang, Frank J Gonzalez
Hepatotoxicity is of major concern for humans exposed to industrial chemicals and drugs. Disruption of farnesoid X receptor (FXR), a master regulator of bile acid (BA) metabolism, enhanced the sensitivity to liver injury in mice after toxicant exposure, but the precise mechanism remains unclear. In this study, the interconnection between BA metabolism, FXR, and chemically-induced hepatotoxicity was investigated using metabolomics, Fxr-null mice and hepatocytes, and adenovirus. A single low-dose intraperitoneal injection of carbon tetrachloride (CCl4), an inducer of acute hepatitis in mice, resulted in more severe hepatocyte damage and higher induction of pro-inflammatory mediators, such as chemokine (C-C motif) ligand 2 (Ccl2), in Fxr-null mice...
May 15, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28505355/uncovering-the-neuroanatomical-correlates-of-cognitive-affective-and-conative-theory-of-mind-in-pediatric-traumatic-brain-injury-a-neural-systems-perspective
#14
Nicholas P Ryan, Cathy Catroppa, Richard Beare, Timothy J Silk, Stephen J Hearps, Miriam H Beauchamp, Keith Owen Yeates, Vicki A Anderson
Deficits in Theory of Mind (ToM) are common after neurological insult acquired in the first and second decade of life, however the contribution of large-scale neural networks to ToM deficits in children with brain injury is unclear. Using pediatric traumatic brain injury (TBI) as a model, this study investigated the sub-acute effect of brain injury on gray-matter volume of three large-scale, domain-general brain networks (the Default Mode Network, DMN; the Central Executive Network, CEN; and the Salience Network, SN), as well as two domain-specific neural networks implicated in social-affective processes (the Cerebro-Cerebellar Mentalizing Network, CCMN, and the Mirror Neuron/Empathy Network, MNEN)...
May 15, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/28502678/il-10-producing-regulatory-b-cells-b10-cells-il-17-t-cells-and-autoantibodies-in-systemic-sclerosis
#15
Athanasios Mavropoulos, Christos Liaskos, Theodora Simopoulou, Dimitrios P Bogdanos, Lazaros I Sakkas
We aimed to analyze IL-10+ Breg (B10) cells, found to be reduced in systemic sclerosis (SSc), in relation to SSc-specific autoAbs and IL-17+ and IFNγ+ T cells in SSc. Peripheral blood B10 cells from 26 patients with SSc positive for anti-Topo I or anti-Cen autoAbs, and 12 healthy controls (HC) were studied by flow cytometry. IL-17+ and IFNγ+ T cells were also studied. B10 cells did not correlate with anti-Topo I or anti-Cen Ab levels but were inversely correlated with IL-17+ CD3+ cells and IFNγ+ CD3+ cells...
May 11, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28492684/oxidative-remediation-of-4-methylcyclohexanemethanol-mchm-and-propylene-glycol-phenyl-ether-pph-evidence-of-contaminant-repair-reaction-pathways
#16
Cen Zhao, Julie R Peller, Stephen P Mezyk, Prashant V Kamat, Kevin E O'Shea
A large spill of 4-methylcyclohexanemethanol (MCHM) and propylene glycol phenyl ether (PPh) into the Elk River near Charleston, West Virginia on January 9, 2014 led to serious water contamination and public concerns about appropriate remediation. To assess the feasibility of advanced oxidation processes (AOPs) for remediation of waters contaminated with these compounds, we induced hydroxyl radical (HO˙) reactions using time-resolved and steady-state radiolysis methods. Detailed product analyses showed initial HO˙ attack was at the benzene ring of PPh, and occurred through H-atom abstraction reactions for MCHM...
May 11, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28489061/microbial-natural-product-alternariol-5-o-methyl-ether-inhibits-hiv-1-integration-by-blocking-nuclear-import-of-the-pre-integration-complex
#17
Jiwei Ding, Jianyuan Zhao, Zhijun Yang, Ling Ma, Zeyun Mi, Yanbing Wu, Jiamei Guo, Jinmin Zhou, Xiaoyu Li, Ying Guo, Zonggen Peng, Tao Wei, Haisheng Yu, Liguo Zhang, Mei Ge, Shan Cen
While Highly Active Antiretroviral Therapy (HAART) has significantly decreased the mortality of human immunodeficiency virus (HIV)-infected patients, emerging drug resistance to approved HIV-1 integrase inhibitors highlights the need to develop new antivirals with novel mechanisms of action. In this study, we screened a library of microbial natural compounds from endophytic fungus Colletotrichum sp. and identified alternariol 5-O-methyl ether (AME) as a compound that inhibits HIV-1 pre-integration steps. Time-of addition analysis, quantitative real-time PCR, confocal microscopy, and WT viral replication assay were used to elucidate the mechanism...
May 10, 2017: Viruses
https://www.readbyqxmd.com/read/28488578/triterpenoids-from-aglaia-abbreviata-exert-cytotoxicity-and-multidrug-resistant-reversal-effect-in-mcf-7-adm-cells-via-reactive-oxygen-species-induction-and-p-glycoprotein-inhibition
#18
Juan Cen, Beibei Zheng, Rubing Bai, Li Zhang, Feng Zhang, Xia Zhang
Triterpenoids from the Aglaia have been shown cytotoxicity on a broad spectrum of human tumor cells. In the present study, we extracted triterpenoids AA-5 (1) and AA-6 (2) from stems of Aglaia abbreviata, and studied their cytotoxicity in multidrug resistant (MDR) MCF-7/ADM cells. After 48 h treatment, AA-5 (1) and AA-6 (2) significantly increased mitochondrial-mediated apoptosis by enhancing reactive oxygen species (ROS) with depressed mitochondrial membrane potential and caspase-9 activities. The drug efflux transporter P-glycoprotein (P-gp) and the intracellular antioxidant systems, involving Glutathione S-Transferase π, Glutathione and heme oxygenase-1, were also inhibited via the ROS-depressed Akt/NF-E2-related factor 2 pathway...
April 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28487269/the-function-of-line-1-encoded-reverse-transcriptase-in-tumorigenesis
#19
Ye Zhongjie, Liu Qipeng, Cen Shan, Li Xiaoyu
The retrotransposon LINE-1 is the largest transposon family of humans with an estimated 500 000 copies representing 17% of the human genome. Meanwhile, it is also the sole autonomous transposon in humans. The reverse transcriptase encoded by LINE-1 is the key component required for its transposition process. Recent evidence suggests that the LINE-1-encoded reverse transcriptase is involved in many important physiological and pathological processes including tumorigenesis. The inhibition of LINE-1-encoded reverse transcriptase inhibits tumor progression, restores cancer cell differentiation and reprograms global transcription profiles...
May 20, 2017: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/28486759/strain-coupling-of-conversion-type-fe3o4-thin-film-for-lithium-ion-battery
#20
Sooyeon Hwang, Qingping Meng, Ping-Fan Chen, Kim Kisslinger, Jiajie Cen, Alexander Orlov, Yimei Zhu, Eric Stach, Ying-Hao Chu, Dong Su
The lithiation/delithiation induce significant stresses and strains into the electrodes for lithium ion batteries, which can severely degrade their cycling performance. Moreover, these electrochemically-induced strain can interact with the local strain existing at solid-solid interfaces. It is not clear how this interaction affects the lithiation mechanism. Here, we investigate the effect of this coupling on the lithiation kinetics in epitaxial Fe3O4 thin film on a Nb-doped SrTiO3 substrate. Our in-situ and ex-situ transmission electron microscopy (TEM) results show that the lithiation is suppressed by the compressive interfacial strain...
May 9, 2017: Angewandte Chemie
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