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https://www.readbyqxmd.com/read/28214842/inhibition-of-methylglyoxal-induced-ages-rage-expression-contributes-to-dermal-protection-by-n-acetyl-l-cysteine
#1
Chun-Tao Yang, Fu-Hui Meng, Li Chen, Xiang Li, Lai-Jian Cen, Yu-Hua Wen, Hui Zhang, Cai-Chen Li
BACKGROUND/AIM: Accumulation of advanced glycation end products (AGEs) is a major cause of diabetes mellitus (DM) skin complications. Methylglyoxal (MGO), a reactive dicarbonyl compound, is a crucial intermediate of AGEs generation. N-acetyl-L-cysteine (NAC), an active ingredient of some medicines, can induce endogenous GSH and hydrogen sulfide generation, and set off a condensation reaction with MGO. However, there is rare evidence to show NAC can alleviate DM-induced skin injury through inhibition of AGEs generation or toxicity...
February 13, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28204828/tieg1-deficiency-confers-enhanced-myocardial-protection-in-the-infarcted-heart-by-mediating-the-pten-akt-signalling-pathway
#2
Mingqiu Cen, Pengfei Hu, Zhaobin Cai, Tianfu Fang, Jiancheng Zhang, Ming Lu
The transforming growth factor (TGF)-β-inducible early gene-1 (TIEG1) plays a crucial role in modulating cell apoptosis and proliferation in a number of diseases, including pancreatic cancer, leukaemia and osteoporosis. However, the functional role of TIEG1 in the heart has not been fully defined. In this study, we first investigated the role of TIEG1 in ischaemic heart disease. For in vitro experiments, cardiomyocytes were isolated from both TIEG1 knockout (KO) and wile-type (WT) mice, and the apoptotic ratios were evaluated after a 48‑h ischaemic insult...
February 13, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28198759/how-specialty-certification-influences-professional-practice
#3
Sharon Vanairsdale
Certified Nurses Day (March 19) honors nurses worldwide who contribute to better patient outcomes through board certification in their specialty. In this month's Magnet® Perspectives column, Sharon Vanairsdale, MS, APRN, ACNS-BC, NP-C, CEN, program director for Emory University Hospital's Serious Communicable Diseases Unit, discusses the value of certification, what it means to her professional practice, and how it helps to champion her work. Ms Vanairsdale is triple certified as a certified emergency nurse, an adult clinical nurse specialist, and an adult nurse practitioner...
March 2017: Journal of Nursing Administration
https://www.readbyqxmd.com/read/28198717/mitochondrial-dna-induced-inflammatory-responses-and-lung-injury-in-thermal-injury-rat-model-protective-effect-of-epigallocatechin-gallate
#4
Ruiqi Liu, Fei Xu, Si Si, Xueshan Zhao, Siwei Bi, Ying Cen
Lungs are easily damaged by the inflammatory responses induced after extensive burns. The aim here was to investigate the protective role of epigallocatechin gallate (EGCG) in mitochondrial DNA (mtDNA)-mediated inflammatory responses and acute respiratory distress syndrome (ARDS) in a rat model of thermal injury. Male Sprague-Dawley rats were randomly assigned to five groups. In the first experiment, a full-thickness thermal injury or control procedure, covering 30% of the TBSA, was inflicted on three groups designated as the thermal injury, EGCG, and sham control groups...
February 6, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28194428/identification-of-palmitoleic-acid-controlled-by-mtor-signaling-as-a-biomarker-of-polymyositis
#5
Geng Yin, Ying Wang, Xiao-Min Cen, Yuan Yang, Min Yang, Qi-Bing Xie
Polymyositis (PM) is a chronic disease characterized by muscle pain, weakness, and increase in muscle-related enzymes, accompanied with inflammations in lymphocytes. However, it is not well understood how the molecular alternations in lymphocytes contribute to the development of polymyositis. The mechanistic target of rapamycin (mTOR) signaling is the central regulator of metabolism and inflammation in mammalian cells. Based on previous studies, we proposed that mTOR signaling may control inflammatory reactions via lipid metabolism...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28192726/novel-strategy-to-improve-vanillin-tolerance-and-ethanol-fermentation-performances-of-saccharomycere-cerevisiae-strains
#6
Dao-Qiong Zheng, Xin-Na Jin, Ke Zhang, Ya-Hong Fang, Xue-Chang Wu
The aim of this work was to develop a novel strategy for improving the vanillin tolerance and ethanol fermentation performances of Saccharomyces cerevisiae strains. Isogeneic diploid, triploid, and tetraploid S. cerevisiae strains were generated by genome duplication of haploid strain CEN.PK2-1C. Ploidy increments improved vanillin tolerance and diminished proliferation capability. Antimitotic drug methyl benzimidazol-2-ylcarbamate (MBC) was used to introduce chromosomal aberrations into the tetraploid S. cerevisiae strain...
January 26, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28186604/-clinical-and-genetic-features-of-a-patient-with-myeloid-neoplasm-in-association-with-pdgfra-and-evi1-gene-rearrangements
#7
Wenmin Han, Hongying Chao, Min Zhou, Ling Cen, Suning Chen, Xuefeng He, Xuzhang Lu
OBJECTIVE: Todelineate the clinical and genetic features of a patient with myeloproliferative neoplasm (MPN) in association with PDGFRA and EVI1 genes rearrangements. METHODS: Clinical data of the patient was collected. Conventional cytogenetics, fluorescence in situ hybridization (FISH) and nested PCR were carried out for the patient. RESULTS: The patient has featured recurrent rash, joint pain, and intermittent fever. Laboratory tests showed hyperleukocytosis and marked eosinophilia...
February 10, 2017: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/28183318/comparison-of-multi-modal-early-oral-nutrition-for-the-tolerance-of-oral-nutrition-with-conventional-care-after-major-abdominal-surgery-a-prospective-randomized-single-blind-trial
#8
Da-Li Sun, Wei-Ming Li, Shu-Min Li, Yun-Yun Cen, Qing-Wen Xu, Yi-Jun Li, Yan-Bo Sun, Yu-Xing Qi, Yue-Ying Lin, Ting Yang, Qi-Ping Lu, Peng-Yuan Xu
BACKGROUND & AIMS: Early oral nutrition (EON) has been shown to improve recovery of gastrointestinal function, length of stay and mortality after abdominal surgery; however, early oral nutrition often fails during the first week after surgery. Here, a multi-modal early oral nutrition program is introduced to promote recovery of gastrointestinal function and tolerance of oral nutrition. METHODS: Consecutive patients scheduled for abdominal surgery were randomized to the multimodal EON group or a group receiving conventional care...
February 10, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/28182544/a-novel-cluster-head-selection-algorithm-based-on-fuzzy-clustering-and-particle-swarm-optimization
#9
Qingjian Ni, Qianqian Pan, Huimin Du, Cen Cao, Yuqing Zhai
An important objective of wireless sensor network is to prolong the network life cycle, and topology control is of great significance for extending the network life cycle. Based on previous work, for cluster head selection in hierarchical topology control, we propose a solution based on fuzzy clustering preprocessing and particle swarm optimization. More specifically, first, fuzzy clustering algorithm is used to initial clustering for sensor nodes according to geographical locations, where a sensor node belongs to a cluster with a determined probability, and the number of initial clusters is analyzed and discussed...
January 2017: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/28182106/tnf-%C3%AE-induced-the-enhanced-apoptosis-of-mesenchymal-stem-cells-in-ankylosing-spondylitis-by-overexpressing-trail-r2
#10
Zhenhua Liu, Liangbin Gao, Peng Wang, Zhongyu Xie, Shuizhong Cen, Yuxi Li, Xiaohua Wu, Le Wang, Hongjun Su, Wen Deng, Shan Wang, Deng Li, Jinteng Li, Yi Ouyang, Yanfeng Wu, Huiyong Shen
Ankylosing spondylitis (AS) is an autoimmune disease with unknown etiology. Dysregulated mesenchymal stem cells (MSCs) apoptosis may contribute to the pathogenesis of autoimmune diseases. However, apoptosis of MSCs from patients with AS (ASMSCs) has not been investigated yet. The present study aims to assess the apoptosis of bone marrow-derived ASMSCs and to investigate the underlying mechanisms of altered ASMSCs apoptosis. We successfully induced the apoptosis of ASMSCs and MSCs from healthy donors (HDMSCs) using the combination of tumor necrosis factor alpha (TNF-α) and cycloheximide (CHX)...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28181832/a-tumor-targeting-crgd-egfr-sirna-conjugate-and-its-anti-tumor-effect-on-glioblastoma-in-vitro-and-in-vivo
#11
Shuai He, Bohong Cen, Lumin Liao, Zhen Wang, Yixin Qin, Zhuomin Wu, Wenjie Liao, Zhongyi Zhang, Aimin Ji
The epidermal growth factor receptor (EGFR) is an important anti-tumor target. The development of novel molecular-targeted anti-tumor drugs that can target the interior of tumor cells and specifically silence EGFR expression is valuable and promising. In this work, a promising anti-tumor conjugate comprising methoxy-modified EGFR siRNA and cyclic arginine-glycine-aspartic acid (cRGD) peptides, which selectively bind to αvβ3 integrins, was synthesized and examined. To prepare cRGD-EGFR siRNA (cRGD-siEGFR), cRGD was covalently conjugated to the 5'-end of an siRNA sense strand using a thiol-maleimide linker...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28175300/systematic-analysis-of-the-gerontome-reveals-links-between-aging-and-age-related-diseases
#12
Maria Fernandes, Cen Wan, Robi Tacutu, Diogo Barardo, Ashish Rajput, Jingwei Wang, Harikrishnan Thoppil, Daniel Thornton, Chenhao Yang, Alex Freitas, João Pedro de Magalhães
No abstract text is available yet for this article.
November 1, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/28168314/cocoa-butter-like-lipid-production-ability-of-non-oleaginous-and-oleaginous-yeasts-under-nitrogen-limited-culture-conditions
#13
Yongjun Wei, Verena Siewers, Jens Nielsen
Cocoa butter (CB) extracted from cocoa beans is the main raw material for chocolate production. However, growing chocolate demands and limited CB production has resulted in a shortage of CB supply. CB is mainly composed of three different kinds of triacylglycerols (TAGs), POP (C16:0-C18:1-C16:0), POS (C16:0-C18:1-C18:0), and SOS (C18:0-C18:1-C18:0). The storage lipids of yeasts, mainly TAGs, also contain relative high-level of C16 and C18 fatty acids and might be used as CB-like lipids (CBL). In this study, we cultivated six different yeasts, including one non-oleaginous yeast strain, Saccharomyces cerevisiae CEN...
February 6, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28166747/investigating-the-validation-of-the-chinese-mandarin-version-of-the-social-responsiveness-scale-in-a-mainland-china-child-population
#14
Chao-Qun Cen, Ya-Yong Liang, Qiu-Ru Chen, Kai-Yun Chen, Hong-Zhu Deng, Bi-Yuan Chen, Xiao-Bing Zou
BACKGROUND: Researchers from several different countries have found the Social Responsiveness Scale (SRS) to have good psychometric properties. However, to our knowledge, no studies on this subject have been reported in Mainland China. In this study, we investigated the psychometric properties of the Chinese Mandarin version of the SRS when used in Mainland China. METHODS: The reliability and validity of the parent-report SRS in a sample of 749 children of 4- to 14-year-olds: 411 typically developing and 338 clinical participants (202 with autism spectrum disorder (ASD)) were examined...
February 6, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28159935/lncrnas-as-an-intermediate-in-hpv16-promoting-myeloid-derived-suppressor-cell-recruitment-of-head-and-neck-squamous-cell-carcinoma
#15
Xiangrui Ma, Surui Sheng, Jingbiao Wu, Yaping Jiang, Xiaolei Gao, Xiao Cen, Jiashun Wu, Shasha Wang, Yajie Tang, Yaling Tang, Xinhua Liang
The emerging evidence showed that long noncoding RNAs (lncRNAs) are involved in cell growth and apoptosis as well as cancer progression and metastasis of malignant tumor, however, limited data are available on the role of lncRNAs in human papillomavirus (HPV)-associated Head and neck squamous cell carcinomas (HNSCC). Here, we demonstrated that 23.98% of 196 HNSCC cases in Southwest China could be classified as HPV16 infection. The number of MDSCs in HPV-positive HNSCC was significantly higher than normal control, indicating that HPV infection may promote MDSCs aggregation...
February 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28157953/rapidly-and-continuously-frequency-scanning-opto-electronic-oscillator
#16
Qizhuang Cen, Yitang Dai, Feifei Yin, Yue Zhou, Jianqiang Li, Jian Dai, Lan Yu, Kun Xu
An opto-electronic oscillator (OEO) scheme which operates at "chirp oscillation" mode and generates low-phase-noise, frequency-swept microwave is proposed and experimentally demonstrated. This frequency-swept OEO is achieved by embedding a rapidly frequency-scanning microwave filter in an opto-electronic cavity. The filter has fixed passband while its center frequency scans rapidly and periodically at cavity round-trip time, covering a large frequency range (~GHz). Experimentally, the generated frequency-swept microwave is linear frequency-modulated continuous wave (FMCW) which centers at 7 GHz with 1-GHz bandwidth...
January 23, 2017: Optics Express
https://www.readbyqxmd.com/read/28152238/assessment-of-segmental-myocardial-blood-flow-and-myocardial-perfusion-reserve-by-adenosine-stress-myocardial-arterial-spin-labeling-perfusion-imaging
#17
Andrew J Yoon, Hung Phi Do, Steven Cen, Michael W Fong, Farhood Saremi, Mark L Barr, Krishna S Nayak
PURPOSE: To determine the feasibility of measuring increases in myocardial blood flow (MBF) and myocardial perfusion reserve (MPR) on a per-segment basis using arterial spin labeled (ASL) magnetic resonance imaging (MRI) with adenosine vasodilator stress in normal human myocardium. MATERIALS AND METHODS: Myocardial ASL scans at rest and during adenosine infusion were incorporated into a routine 3T MR adenosine-induced vasodilator stress protocol and were performed in 10 healthy human volunteers...
February 2, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28152077/cytokeratin-14-contributes-to-collective-invasion-of-salivary-adenoid-cystic-carcinoma
#18
Xiao-Lei Gao, Jia-Shun Wu, Min-Xin Cao, Shi-Yu Gao, Xiao Cen, Ya-Ping Jiang, Sha-Sha Wang, Ya-Jie Tang, Qian-Ming Chen, Xin-Hua Liang, Yaling Tang
Collective invasion of cells plays a fundamental role in tissue growth, wound healing, immune response and cancer metastasis. This paper aimed to investigate cytokeratin-14 (CK14) expression and analyze its association with collective invasion in the invasive front of salivary adenoid cystic carcinoma (SACC) to uncover the role of collective invasion in SACC. Here, in the clinical data of 121 patients with SACC, the positive expression of CK14 was observed in 35/121(28.93%) of the invasive front of SACC. CK14 expression in the invasive front, local regional recurrence and distant metastasis were independent and significant prognostic factors in SACC patients...
2017: PloS One
https://www.readbyqxmd.com/read/28147209/electronic-nicotine-delivery-systems-and-smoking-cessation-in-arkansas-2014
#19
Uwemedimbuk S Ekanem, Victor M Cardenas, Ruiqi Cen, Wanda Simon, Irene P Chedjieu, Morgan Woodward, Robert R Delongchamp, J Gary Wheeler
OBJECTIVES: As of October 2015, evidence needed to make a recommendation about the use of electronic nicotine delivery systems (ENDS) for smoking cessation was limited. We used the 2014 Arkansas Behavioral Risk Factor Surveillance System with additional state-specific questions to determine the prevalence of ENDS use, the impact of ENDS use on smoking cessation, and beliefs about ENDS use in Arkansas. Our objectives were to determine if (1) ENDS use was associated with lower odds of quitting smoking, (2) ENDS users believed that ENDS use was not harmful to their health, and (3) ENDS users believed that switching to ENDS reduced their tobacco-related health risks...
January 1, 2017: Public Health Reports
https://www.readbyqxmd.com/read/28145504/honeybee-locomotion-is-impaired-by-am-cav3-low-voltage-activated-ca-2-channel-antagonist
#20
M Rousset, C Collet, T Cens, F Bastin, V Raymond, I Massou, C Menard, J-B Thibaud, M Charreton, M Vignes, M Chahine, J C Sandoz, P Charnet
Voltage-gated Ca(2+) channels are key transducers of cellular excitability and participate in several crucial physiological responses. In vertebrates, 10 Ca(2+) channel genes, grouped in 3 families (CaV1, CaV2 and CaV3), have been described and characterized. Insects possess only one member of each family. These genes have been isolated in a limited number of species and very few have been characterized although, in addition to their crucial role, they may represent a collateral target for neurotoxic insecticides...
February 1, 2017: Scientific Reports
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