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https://www.readbyqxmd.com/read/28631225/definition-of-the-upper-reference-limit-for-thyroglobulin-antibodies-according-to-the-national-academy-of-clinical-biochemistry-guidelines-comparison-of-eleven-different-automated-methods
#1
F D'Aurizio, P Metus, A Ferrari, B Caruso, R Castello, D Villalta, A Steffan, K Gaspardo, F Pesente, N Bizzaro, E Tonutti, S Valverde, C Cosma, M Plebani, R Tozzoli
PURPOSE: In the last two decades, thyroglobulin autoantibodies (TgAb) measurement has progressively switched from marker of thyroid autoimmunity to test associated with thyroglobulin (Tg) to verify the presence or absence of TgAb interference in the follow-up of patients with differentiated thyroid cancer. Of note, TgAb measurement is cumbersome: despite standardization against the International Reference Preparation MRC 65/93, several studies demonstrated high inter-method variability and wide variation in limits of detection and in reference intervals...
December 2017: Auto- Immunity Highlights
https://www.readbyqxmd.com/read/28615426/modulation-of-intrinsic-resting-state-fmri-networks-in-women-with-chronic-migraine
#2
X Michelle Androulakis, Kaitlin Krebs, B Lee Peterlin, Tianming Zhang, Nasim Maleki, Souvik Sen, Chris Rorden, Priyantha Herath
OBJECTIVE: To evaluate the intrinsic resting functional connectivity of the default mode network (DMN), salience network (SN), and central executive network (CEN) network in women with chronic migraine (CM), and whether clinical features are associated with such abnormalities. METHODS: We analyzed resting-state connectivity in 29 women with CM as compared to age- and sex-matched controls. Relationships between clinical characteristics and changes in targeted networks connectivity were evaluated using a multivariate linear regression model...
June 14, 2017: Neurology
https://www.readbyqxmd.com/read/28612496/rin1-promotes-renal-cell-carcinoma-malignancy-by-activating-egfr-signalling-through-rab25
#3
Zi-Hao Feng, Yong Fang, Liang-Yun Zhao, Jun Lu, Yong-Qian Wang, Zhen-Hua Chen, Yong Huang, Jin-Huan Wei, Yan-Ping Liang, Jun-Jie Cen, Yi-Hui Pan, Bing Liao, Wei Chen, Jun-Hang Luo
We previously identified the important role of RIN1 expression in the prognosis of clear cell renal cell carcinoma (ccRCC). The role of RIN1 in ccRCC malignancy and underlying molecular mechanisms remain unclear. Here we report that ccRCC cells and tissues expressed more RIN1 than normal controls. Gain- and loss-of-function studies demonstrated that RIN1 enhanced ccRCC cell growth, migration and invasion abilities in vitro and promoted tumor growth and metastasis in vivo. Mechanistic studies revealed that RIN1 has an activating effect on EGFR signalling in ccRCC...
June 14, 2017: Cancer Science
https://www.readbyqxmd.com/read/28609941/mitochondrial-genome-of-i-abraxas-i-i-suspecta-i-lepidoptera-geometridae-%C3%A2-and-comparative-analysis-with-other-lepidopterans
#4
Y U Sun, Jiawei Zhang, Qingqing Li, Dan Liang, Muhammad Nadeem Abbas, Cen Qian, Lei Wang, Guoqing Wei, Bao-Jian Zhu, Chao-Liang Liu
In this study, a complete mitochondrial genome (mitogenome) sequence of Abraxas suspecta (Lepidoptera: Geometridae) is isolated and characterized. The complete DNA is 15,547 bp length and contains 2 ribosomal RNA genes, 23 putative transfer RNA (tRNA) genes including an extra tRNAAsn (AUU), 13 protein-coding genes and an adenine (A) + thymine (T)-rich region. The nucleotide composition and gene organization are identical to those of other lepidopteran, except for the presence of an extra copy of trnN (AUU)...
April 20, 2017: Zootaxa
https://www.readbyqxmd.com/read/28604663/elevated-traf4-expression-impaired-lps-induced-autophagy-in-mesenchymal-stem-cells-from-ankylosing-spondylitis-patients
#5
Jinteng Li, Peng Wang, Zhongyu Xie, Rui Yang, Yuxi Li, Xiaohua Wu, Hongjun Su, Wen Deng, Shan Wang, Zhenhua Liu, Shuizhong Cen, Yi Ouyang, Yanfeng Wu, Huiyong Shen
Ankylosing spondylitis (AS) is a type of autoimmune disease that predominantly affects the spine and sacroiliac joints. However, the pathogenesis of AS remains unclear. Some evidence indicates that infection with bacteria, especially Gram-negative bacteria, may have an important role in the onset and progression of AS. Recently, many studies have demonstrated that mesenchymal stem cells (MSCs) dysfunction may contribute to the pathogenesis of many rheumatic diseases. We previously demonstrated that MSCs from AS patients exhibited markedly enhanced osteogenic differentiation capacity in vitro under non-inflammatory conditions...
June 9, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/28601327/milk-fat-globule-epidermal-growth-factor-factor-viii-attenuates-sepsis-induced-acute-kidney-injury
#6
Cindy Cen, Monowar Aziz, Weng-Lang Yang, Mian Zhou, Jeffrey M Nicastro, Gene F Coppa, Ping Wang
BACKGROUND: Acute kidney injury (AKI) is most commonly caused by sepsis in critically ill patients, and it is associated with high morbidity and mortality. The pathophysiology of sepsis-induced AKI is generally accepted to include direct inflammatory injury, endothelial cell dysfunction, and apoptosis. Milk fat globule-epidermal growth factor-factor VIII (MFG-E8) is a secretory glycoprotein with a known role in the enhancement of apoptotic cell clearance and regulation of inflammation...
June 1, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28600943/investigating-hydrothermal-pretreatment-of-food-waste-for-two-stage-fermentative-hydrogen-and-methane-co-production
#7
Lingkan Ding, Jun Cheng, Dan Qiao, Liangchen Yue, Yu-You Li, Junhu Zhou, Kefa Cen
The growing amount of food waste (FW) in China poses great pressure on the environment. Complex solid organics limit the hydrolysis of FW, hence impairing anaerobic digestion. This study employed hydrothermal pretreatment (HTP) to facilitate the solubilization of FW. When HTP temperature increased from 100 to 200°C, soluble carbohydrate content first increased to a peak at 140°C and then decreased, whereas total carbohydrate content was negatively correlated with increasing temperature due to the enhanced degradation and Maillard reactions...
May 20, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28600311/laboratory-evolution-of-a-biotin-requiring-saccharomyces-cerevisiae-strain-for-full-biotin-prototrophy-and-identification-of-causal-mutations
#8
Jasmine M Bracher, Erik de Hulster, Charlotte C Koster, Marcel van den Broek, Jean-Marc G Daran, Antonius J A van Maris, Jack T Pronk
Biotin prototrophy is a rare, incompletely understood and industrially relevant characteristic of Saccharomyces cerevisiae strains. The genome of the haploid laboratory strain CEN.PK113-7D contains a full complement of biotin biosynthesis genes, but its growth in biotin-free synthetic media is extremely slow (specific growth rate μ ≈ 0.01 h(-1)). Four independent evolution experiments in repeated batch cultures and accelerostats yielded strains whose growth rates (μ up to 0.36 h(-1)) in biotin-free and biotin-supplemented medium were similar...
June 9, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28598968/comparative-mitochondrial-genome-analysis-of-daphnis-nerii-and-other-lepidopteran-insects-reveals-conserved-mitochondrial-genome-organization-and-phylogenetic-relationships
#9
Yu Sun, Chen Chen, Jin Gao, Muhammad Nadeem Abbas, Saima Kausar, Cen Qian, Lei Wang, Guoqing Wei, Bao-Jian Zhu, Chao-Liang Liu
In the present study, the complete sequence of the mitochondrial genome (mitogenome) of Daphnis nerii (Lepidoptera: Sphingidae) is described. The mitogenome (15,247 bp) of D.nerii encodes13 protein-coding genes (PCGs), 22 transfer RNA genes (tRNAs), two ribosomal RNA genes (rRNAs) and an adenine (A) + thymine (T)-rich region. Its gene complement and order is similar to that of other sequenced lepidopterans. The 12 PCGs initiated by ATN codons except for cytochrome c oxidase subunit 1 (cox1) gene that is seemingly initiated by the CGA codon as documented in other insect mitogenomes...
2017: PloS One
https://www.readbyqxmd.com/read/28596955/flux-enabled-exploration-of-the-role-of-sip1-in-galactose-yeast-metabolism
#10
Christopher M Shymansky, George Wang, Edward E K Baidoo, Jennifer Gin, Amanda Reider Apel, Aindrila Mukhopadhyay, Héctor García Martín, Jay D Keasling
(13)C metabolic flux analysis ((13)C MFA) is an important systems biology technique that has been used to investigate microbial metabolism for decades. The heterotrimer Snf1 kinase complex plays a key role in the preference Saccharomyces cerevisiae exhibits for glucose over galactose, a phenomenon known as glucose repression or carbon catabolite repression. The SIP1 gene, encoding a part of this complex, has received little attention, presumably, because its knockout lacks a growth phenotype. We present a fluxomic investigation of the relative effects of the presence of galactose in classically glucose-repressing media and/or knockout of SIP1 using a multi-scale variant of (13)C MFA known as 2-Scale (13)C metabolic flux analysis (2S-(13)C MFA)...
2017: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/28595013/fibroblast-activation-protein-alpha-activated-tripeptide-bufadienolide-anti-tumor-prodrug-with-reduced-cardiotoxicity
#11
Li-Juan Deng, Long-Hai Wang, Cheng-Kang Peng, Yi-Bin Li, Mao-Hua Huang, Min-Feng Chen, Xue-Ping Lei, Ming Qi, Yun Cen, Wen-Cai Ye, Dong-Mei Zhang, Wei-Min Chen
Bufadienolides are the major pharmacologic constituents of traditional Chinese medicine Chan'su, which are frequently used clinically for cancer treatment in China. Motivated by reducing or avoiding the cardiac toxicity of bufadienolides, we have designed, synthesized and evaluated the fibroblast activation protein alpha (FAPα)-activated tripeptide arenobufagin prodrugs with the purpose of improving the safety of arenobufagin (a representative bufadienolide). Among these FAPα-activated prodrugs, 3f exhibited the best hydrolytic efficiency by recombinant human FAPα (rhFAPα), and are selectively activated in tumors...
June 8, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28588699/irradiation-of-peripheral-blood-mononuclear-cells-with-7-5-gy-x-rays-prior-to-donor-lymphocyte-infusion-inhibits-proliferation-while-preserving-cytotoxicity-and-improves-the-effectiveness-of-hsct-in-patients-with-hematological-malignancies
#12
Yong-Qiu Wei, Xi-Nan Cen, Hui-Hui Liu, Yu-Hua Sun, Yong-Jin Shi, Wei Liu, Yu-Jun Dong, Han-Yun Ren
The aim of the present study was to explore the effect of different X-ray doses on the proliferation and cytotoxic activity of peripheral blood mononuclear cells (PBMCs), particularly lymphocytes, in order to assess whether this reduces the incidence of graft vs. host disease (GVHD) while preserving the graft vs. tumor (GVT) effect in patients with hematological malignancies following hematopoietic stem cell transplantation (HSCT). PBMCs from healthy donors were irradiated with X-rays at doses of 0, 2.5, 5, 7...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28583199/role-of-mesenchymal-stem-cells-their-derived-factors-and-extracellular-vesicles-in-liver-failure
#13
REVIEW
Jie Wang, Panpan Cen, Jiajia Chen, Linxiao Fan, Jun Li, Hongcui Cao, Lanjuan Li
Liver failure is a severe clinical syndrome with a poor prognosis. Mesenchymal stem cell (MSC) transplantation has emerged as a new intervention in treating liver failure. It is conventionally recognized that MSCs exert their therapeutic effect mainly through transdifferentiation. Recently, published articles have shown that MSCs work in liver failure by secreting trophic and immunomodulatory factors as well as extracellular vesicles (EVs) before transdifferentiation. In particular,MSC-derived EVs have shown similar curative effects as MSCs...
June 6, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28577360/aeroembolism-in-left-atrium-during-catheter-ablation-of-atrial-fibrillation-in-a-patient-with-dextrocardia-a-case-report-and-review-of-the-literature
#14
Yun-Fan Wang, Xue-Jiang Cen, Jian-Wu Yu, Bai-Ming Qu, Li-Hong Wang
BACKGROUND: Air embolus penetrating into heart chamber as a complication during percutaneous radiofrequency catheter ablation has been infrequently reported. CASE PRESENTATION: A 55-year-old man with dextrocardia who suffered from abdominal pain was suspected to have multiple arterial thromboembolisms, which might have originated from left atrium thrombosis since he had atrial fibrillation. He received oral anticoagulant therapy and catheter ablation of the arrhythmia...
June 2, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28576903/the-taking-charge-after-stroke-tacas-study-protocol-a-multicentre-investigator-blinded-randomised-controlled-trial-comparing-the-effect-of-a-single-take-charge-session-two-take-charge-sessions-and-control-intervention-on-health-related-quality-of-life-12-months
#15
Vivian Wai Yin Fu, Mark Weatherall, Harry McNaughton
INTRODUCTION: Stroke is one of the leading causes of disability worldwide. Recent data support the possibility that person-centred, self-management interventions can reduce dependence after stroke. However, there is limited information on the generalisability and optimum dose of these interventions. METHODS: The Taking Charge After Stroke (TaCAS) study is a multicentre, investigator-blinded, randomised controlled trial recruiting 400 participants following acute stroke from seven hospitals in New Zealand...
June 1, 2017: BMJ Open
https://www.readbyqxmd.com/read/28576044/effects-of-dnase-i-coating-of-titanium-on-bacteria-adhesion-and-biofilm-formation
#16
Jing Ye, Can Shao, Xu Zhang, Xuyun Guo, Ping Gao, Yunzhu Cen, Shiqing Ma, Ying Liu
The removal of mature biofilm from the surface of implant has been a formidable challenge in treating implant-associated infection. Prevention of biofilm formation rather than removal of existing biofilm is a more effective approach. Immobilization of biofilm-dispersing enzymes on material surfaces is regarded as one of the most promising strategies. Deoxyribonuclease I (DNase I) can degrade extracellular DNA (eDNA) and then destabilize biofilm. In this study, DNase I was immobilized on a titanium (Ti) surface by using dopamine as an intermediate...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28574547/a-substituent-effect-of-phenylacetic-acid-coligand-perturbed-structures-and-magnetic-properties-observed-in-two-triple-bridged-azido-cu-ii-chain-compounds-with-ferromagnetic-ordering-and-slow-magnetic-relaxation
#17
Xiangyu Liu, Xiaohui Ma, Peipei Cen, Yuewei Wu, Chengcheng Zhang, Quan Shi, Weiming Song, Gang Xie, Sanping Chen
Based on two fluoro-substituted phenylacetate isomers, o-fluorophenylacetic acid (o-Hfpa) and p-fluorophenylacetic acid (p-Hfpa), two new Cu(ii)-azido compounds, [Cu(o-fpa)(N3)(C2H5OH)]n (1) and [Cu(p-fpa)(N3)(C2H5OH)]n (2), have been prepared, and structurally and magnetically characterized. Single-crystal structure analyses indicate that compounds 1 and 2 consist of 1D chain-like coordination networks in which adjacent copper cations are linked by the alternating triple-bridges of μ-1,1-azido, syn,syn-carboxylate and μ2-ethanol...
June 13, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28574315/the-effect-of-nachri-children-s-hospital-designation-on-outcome-in-pediatric-malignant-brain-tumors
#18
Daniel A Donoho, Timothy Wen, Jonathan Liu, Hosniya Zarabi, Eisha Christian, Steven Cen, Gabriel Zada, J Gordon McComb, Mark D Krieger, William J Mack, Frank J Attenello
OBJECTIVE Although current pediatric neurosurgery guidelines encourage the treatment of pediatric malignant brain tumors at specialized centers such as pediatric hospitals, there are limited data in support of this recommendation. Previous studies suggest that children treated by higher-volume surgeons and higher-volume hospitals may have better outcomes, but the effect of treatment at dedicated children's hospitals has not been investigated. METHODS The authors analyzed the Healthcare Cost and Utilization Project Kids' Inpatient Database (KID) from 2000-2009 and included all patients undergoing a craniotomy for malignant pediatric brain tumors based on ICD-9-CM codes...
June 2, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28572766/conversion-discriminative-analysis-on-mild-cognitive-impairment-using-multiple-cortical-features-from-mr-images
#19
Shengwen Guo, Chunren Lai, Congling Wu, Guiyin Cen
Neuroimaging measurements derived from magnetic resonance imaging provide important information required for detecting changes related to the progression of mild cognitive impairment (MCI). Cortical features and changes play a crucial role in revealing unique anatomical patterns of brain regions, and further differentiate MCI patients from normal states. Four cortical features, namely, gray matter volume, cortical thickness, surface area, and mean curvature, were explored for discriminative analysis among three groups including the stable MCI (sMCI), the converted MCI (cMCI), and the normal control (NC) groups...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28572571/a-molecular-roadmap-for-induced-multi-lineage-trans-differentiation-of-fibroblasts-by-chemical-combinations
#20
Xiaoping Han, Hao Yu, Daosheng Huang, Yang Xu, Assieh Saadatpour, Xia Li, Lengmei Wang, Jie Yu, Luca Pinello, Shujing Lai, Mengmeng Jiang, Xueying Tian, Fen Zhang, Yanhong Cen, Yuko Fujiwara, Wei Zhu, Bin Zhou, Tianhua Zhou, Hongwei Ouyang, Jianan Wang, Guo-Cheng Yuan, Shumin Duan, Stuart H Orkin, Guoji Guo
No abstract text is available yet for this article.
June 2017: Cell Research
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