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https://www.readbyqxmd.com/read/29913455/grape-leucoanthocyanidin-protects-liver-tissue-in-albino-rabbits-with-nonalcoholic-hepatic-steatosis
#1
Reginaldo Franklin, Rodrigo Freitas Monte Bispo, Célio Fernando Sousa-Rodrigues, Lucas Alves Sarmento Pires, Albino Fonseca, Marcio Antonio Babinski
Nonalcoholic fatty liver disease (NAFLD) is a common ailment. It is usually found in association with diabetes or obesity. There are no approved drugs to treat this condition. The study of flavonoid consumption has increased over the decades due to their antioxidative properties, although the literature is scarce when it comes to their effects in liver tissue. The purpose of this study was to evaluate the role of leucoanthocyanidin in nonalcoholic hepatic steatosis. Thirty male albino rabbits were divided in 3 groups...
June 18, 2018: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/29911994/fasting-induced-jmjd3-histone-demethylase-epigenetically-activates-mitochondrial-fatty-acid-%C3%AE-oxidation
#2
Sunmi Seok, Young-Chae Kim, Sangwon Byun, Sunge Choi, Zhen Xiao, Naoki Iwamori, Yang Zhang, Chaochen Wang, Jian Ma, Kai Ge, Byron Kemper, Jongsook Kim Kemper
Jumonji D3 (JMJD3) histone demethylase epigenetically regulates development and differentiation, immunity, and tumorigenesis by demethylating a gene repression histone mark, H3K27-me3, but a role for JMJD3 in metabolic regulation has not been described. SIRT1 deacetylase maintains energy balance during fasting by directly activating both hepatic gluconeogenic and mitochondrial fatty acid β-oxidation genes, but the underlying epigenetic and gene-specific mechanisms remain unclear. In this study, JMJD3 was identified unexpectedly as a gene-specific transcriptional partner of SIRT1 and epigenetically activated mitochondrial β-oxidation, but not gluconeogenic, genes during fasting...
June 18, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29911451/effect-of-well-controlled-gestational-diabetes-on-left-ventricular-diastolic-dysfunction-in-neonates
#3
Yazdan Ghandi, Danial Habibi, Khadijeh Nasri, Saeed Alinejad, Hassan Taherahmad, Ali Arjmand Shabestari, Ali Nematinejad
BACKGROUND: There are some evidences supporting the relation between gestational diabetes mellitus (GDM) and diastolic dysfunction. The aim of our study was to investigate the effect of well-controlled GDM on morphological and functional myocardium. MATERIALS AND METHODS: We designed a prospective cross-sectional study to evaluate left ventricular (LV) diastolic function of 60 neonates born from mothers with well-controlled GDM (case group) on days of 3-5 after birth...
June 17, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29910467/gut-microbiota-modulate-neurobehavior-through-changes-in-brain-insulin-sensitivity-and-metabolism
#4
Marion Soto, Clémence Herzog, Julian A Pacheco, Shiho Fujisaka, Kevin Bullock, Clary B Clish, C Ronald Kahn
Obesity and diabetes in humans are associated with increased rates of anxiety and depression. To understand the role of the gut microbiome and brain insulin resistance in these disorders, we evaluated behaviors and insulin action in brain of mice with diet-induced obesity (DIO) with and without antibiotic treatment. We find that DIO mice have behaviors reflective of increased anxiety and depression. This is associated with decreased insulin signaling and increased inflammation in in the nucleus accumbens and amygdala...
June 18, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29909933/community-pharmacist-led-employer-based-wellness-services-a-pilot-study
#5
Justin Gatwood, Rhonda Hanley, Joe S Moore, Kenneth Hohmeier
The emphasis that United States employers are placing on employee wellness continues to grow; however, most attention has been paid to larger firms to gauge return-on-investment from a larger pool of enrollees. With fewer resources available to fund expansive wellness programs, smaller businesses need a cost-effective mechanism to provide such benefits. As the most accessible healthcare provider, community pharmacists are in an ideal position to support certain wellness programs for smaller businesses. This research piloted a community pharmacist-led, employer-sponsored wellness program for a self-insured financial services company in Tennessee...
June 12, 2018: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29909574/the-possible-antidiabetic-effects-of-vitamin-d-receptors-agonist-in-rat-model-of-type-2-diabetes
#6
Wafaa M Abdel-Rehim, Rasha A El-Tahan, Mennatullah A El-Tarawy, Rowaida R Shehata, Maher A Kamel
Vitamin D3 deficiency was found to be tightly linked to many health problems including metabolic syndrome, cancer, cardiovascular diseases, and type 2 diabetes mellitus. In our study, we tested the possible antidiabetic effects of one of vitamin D3 analogs, alfacalcidol, solely or in a combination with metformin on type 2 diabetic rats. Type 2 diabetic model rats were induced by feeding high-fat diet for 4 weeks followed by intraperitoneal injection of streptozotocin. In addition to the control group, the diabetic rats were divided into four groups: untreated, metformin-treated, alfacalcidol-treated, and combination-treated group (metformin + alfacalcidol) for 4 weeks...
June 16, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29909161/-host-microbiota-crosstalk-and-cardiovascular-diseases
#7
Jacques Amar
When analyzing the microbiota-host crosstalk, we have to consider three participants in this dialogue: the gut microbiota, the intestinal barrier and bacterial translocation. Experimental data demonstrate that host microbiota crosstalk plays a causal on the regulation of blood pressure, glucose metabolism and the development of atherosclerosis. Host microbiota crosstalk is associated in humans with main cardiovascular risk factors notably hypertension and type 2 diabetes. Host microbiota crosstalk is associated in humans with the onset of cardiovascular diseases...
June 13, 2018: La Presse Médicale
https://www.readbyqxmd.com/read/29909009/knockout-of-cnr1-prevents-metabolic-stress-induced-cardiac-injury-through-improving-insulin-resistance-ir-injury-and-endoplasmic-reticulum-er-stress-by-promoting-ampk-alpha-activation
#8
Su-Juan Pei, Huai-Yuan Zhu, Jin-Hui Guo, Xin Zhang, Zhi-Jian Deng
Obesity and diabetes are associated with diabetic cardiomyopathy (DCM). However, the pathogenesis of DCM is not fully understood. Cannabinoid receptor gene (CNR1) has been a drug target for the treatment of obesity. Here, we reported that CNR1 expression was increased in high fat diet (HFD)-induced heart of mice. Following, the wild type (CNR1+/+ ) and CNR1-knockout (CNR1-/- ) mice were employed and subjected to HFD treatments for 16 weeks to further investigate the effects of CNR1 on DCM. The results indicated that CNR1 knockout mice after HFD feeding exhibited a significant decrease of body weight and lipid accumulation in serum...
June 14, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29908010/rapamycin-improves-insulin-resistance-and-hepatic-steatosis-in-type-2-diabetes-rats-through-activation-of-autophagy
#9
Wan Zhou, Shandong Ye
Insulin resistance (IR) is a hallmark of type 2 diabetes mellitus (T2DM). This study aimed to explore the effects of rapamycin, a specific inhibitor of kinase mammalian target of rapamycin (mTOR), on IR in T2DM rats, and to validate whether the underlying mechanism was associated with autophagy. In this study, the model of T2DM rats was established by feeding the animals with a high-fat diet (HFD) and intraperitoneal injection of streptozotocin (STZ). Diabetic rats were randomly divided into model of T2DM control group (DM-C, n=15), metformin group (DM-M, n=15), rapamycin group (DM-Rapa, n=15), 3-methyladenine (3-MA) group (DM-3-MA, n=15), and rapamycin+3-MA group (DM-Rapa-3-MA, n=15)...
June 16, 2018: Cell Biology International
https://www.readbyqxmd.com/read/29907811/obesity-type-ii-diabetes-promotes-function-limiting-changes-in-murine-tendons-that-are-not-reversed-by-restoring-normal-metabolic-function
#10
Valentina Studentsova, Keshia M Mora, Melissa F Glasner, Mark R Buckley, Alayna E Loiselle
Type II Diabetes (T2DM) negatively alters baseline tendon function, including decreased range of motion and mechanical properties; however, the biological mechanisms that promote diabetic tendinopathy are unknown. To facilitate identification of therapeutic targets we developed a novel murine model of diabetic tendinopathy. Mice fed a High Fat Diet (HFD) developed diet induced obesity and T2DM and demonstrated progressive impairments in tendon gliding function and mechanical properties, relative to mice fed a Low Fat Diet (LFD)...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907450/altered-maternal-and-placental-lipid-metabolism-and-fetal-fat-development-in-obesity-current-knowledge-and-advances-in-non-invasive-assessment
#11
Flavien Delhaes, Stephanie A Giza, Tianna Koreman, Genevieve Eastabrook, Charles A McKenzie, Samantha Bedell, Timothy R H Regnault, Barbra de Vrijer
Abnormal maternal lipid profiles, a hallmark of increased maternal adiposity, are associated with pregnancy complications such as preeclampsia and gestational diabetes, and offspring long-term metabolic health is impacted as the consequence of altered fetal growth, physiology and often iatrogenic prematurity. The metabolic changes associated with maternal obesity and/or the consumption of a high-fat diet effecting maternal lipid profiles and metabolism have also been documented to specifically affect placental function and may underlie changes in fetal development and life course disease risk...
May 26, 2018: Placenta
https://www.readbyqxmd.com/read/29907153/comparison-of-two-low-fat-diets-differing-in-protein-and-carbohydrate-on-psychological-wellbeing-in-adults-with-obesity-and-type-2-diabetes-a-randomised-clinical-trial
#12
Nerylee Ann Watson, Kathryn Ann Dyer, Jonathan David Buckley, Grant David Brinkworth, Alison Mary Coates, Gaynor Parfitt, Peter Ranald Charles Howe, Manny Noakes, Karen Joy Murphy
BACKGROUND: Although higher-protein diets (HP) can assist with weight loss and glycemic control, their effect on psychological wellbeing has not been established. The objective of this study was to compare the effects of a HP and a higher-carbohydrate diet (HC), combined with regular exercise, on psychological wellbeing both during weight loss (WL) and weight maintenance phases (WM). METHODS: In a parallel RCT, 61 adults with T2D (mean ± SD: BMI 34.3 ± 5...
June 15, 2018: Nutrition Journal
https://www.readbyqxmd.com/read/29904998/effect-of-low-carbohydrate-diet-on-markers-of-renal-function-in-patients-with-type-2-diabetes-a-meta-analysis
#13
REVIEW
Perdana Samekto Tyasnugroho Suyoto
Meta-analysis was conducted to clarify the effect of low carbohydrate diet (LCD) on renal function in patients with type 2 diabetes mellitus (T2DM). An extensive literature search was conducted on scientific databases including PubMed, Scopus, and Cochrane Library until September 2017. Only controlled trials on human subjects written in English were included in this meta-analysis. Several markers of renal function were compared between subjects who adopted a LCD or control diet, including estimated glomerular filtration rate (eGFR), creatinine clearance, urinary albumin, serum creatinine, and serum uric acid...
June 14, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29903989/dietary-cholesterol-lipid-levels-and-cardiovascular-risk-among-adults-with-diabetes-or-impaired-fasting-glucose-in-the-framingham-offspring-study
#14
Hsuan-Ping Lin, Siyouneh Baghdasarian, Martha R Singer, Melanie M Mott, M Loring Bradlee, Richard T Pickering, Lynn L Moore
Previous recommendations to limit dietary cholesterol intake have been eliminated for most adults. Questions remain about whether dietary cholesterol has adverse cardiovascular effects among individuals with impaired fasting glucose or diabetes (IFG/T2DM). We used data for 993 adults (40.9% female), ages 35⁻<65 years, with prevalent IFG/T2DM in the prospective Framingham Offspring Study to address this question. Dietary cholesterol was assessed using 3-day diet records at exams 3 and 5 and used to classify subjects into sex-specific tertiles of mean cholesterol intake...
June 14, 2018: Nutrients
https://www.readbyqxmd.com/read/29903846/dietary-patterns-over-time-and-microalbuminuria-in-youth-and-young-adults-with-type-1-diabetes-the-search-nutrition-ancillary-study
#15
Tina Costacou, Jamie Crandell, Anna R Kahkoska, Angela D Liese, Dana Dabelea, Jean M Lawrence, David J Pettitt, Kristi Reynolds, Elizabeth J Mayer-Davis, Amy K Mottl
OBJECTIVE: We assessed the association between diet quality and microalbuminuria in youth-onset type 1 diabetes using three indices: a modified Mediterranean diet score for children and adolescents (mKIDMED), the Dietary Approaches to Stop Hypertension (DASH), and the Healthy Eating Index-2010 (HEI). RESEARCH DESIGN AND METHODS: Youth and young adults from the SEARCH (Search for Diabetes in Youth) Nutrition Ancillary Study diagnosed with type 1 diabetes in 2002-2008, who had repeated dietary assessments at baseline and follow-up visits and urine albumin-to-creatinine ratio (UACR) measured at the outcome visit (2012-2015) ( n = 461), were selected for study...
June 14, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29903789/prevalence-and-clustering-of-cardiovascular-risk-factors-a-cross-sectional-survey-among-nanjing-adults-in-china
#16
Xin Hong, Qing Ye, Jing He, Zhiyong Wang, Huafeng Yang, Shengxiang Qi, Xupeng Chen, Chenchen Wang, Hairong Zhou, Chao Li, Zhenzhen Qin, Fei Xu
OBJECTIVES: To estimate prevalence and clustering of cardiovascular risk factors (CRFs), and investigate the association between relevant characteristics and CRF clustering among adults in eastern China. DESIGN: Community-based cross-sectional study. SETTING: Data were collected by interview survey, physical measurements and laboratory examinations from the 2011 Nanjing Chronic Disease and Risk Factor Surveillance. PARTICIPANTS: A representative sample of 41 072 residents aged ≥18 years volunteered to participate in the survey, with a response rate of 91...
June 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29903525/impacts-of-self-management-education-on-glycaemic-control-in-patients-with-type-2-diabetes-mellitus
#17
Deldar Morad Abdulah, Alan Bapeer Hassan, Farsat Saeed Saadi, Ary Habeeb Mohammed
OBJECTIVES: Dietary and physical activity advice have been considered to be seminal ingredients in prevention and management of type 2 diabetes mellitus. In this regard, the impacts of a three-month self-management intervention on glycemic control in patients with type 2 diabetes were examined in the present study. STUDY DESIGN: A Double-arm post-test intervention study. METHODS: In the current post-test intervention study, three two-hour educational sessions on dietary habits and physical activity designed according to Health Belief Model were presented to 16 non-complicated type 2 diabetic patients and their dietary, physical activities, and biochemical outcomes were compared to a 23 patient-control arm in Iraq in 2017...
June 7, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29903238/-effects-of-high-sucrose-high-fat-diet-feeding-time-on-establishment-of-a-mouse-model-of-gestational-diabetes-mellitus
#18
Jiacui Ren, Ye Ding, Lu Yin, Rui Qin, Yuanhong She, Jin Xu, Zhixu Wang
OBJECTIVE: The present study focuses on the effects of different highsucrose/high-fat diet feeding time on body weight, glucose and lipid metabolism parameters and pathological changes of pancreas and liver in pregnant mice. METHODS: Female C57 BL/6 J mice were divided into three groups randomly: normal control group( C) and two different high-sucrose/high-fat diet feeding time groups( H1 and H2). Body weight, food and energy intakes and blood glucose were measured at multiple time points before and during pregnancy...
January 2018: Wei Sheng Yan Jiu, Journal of Hygiene Research
https://www.readbyqxmd.com/read/29903193/-prevalence-and-change-of-type-2-diabetes-mellitus-among-rural-adults-in-deqing-county-zhejiang-province-in-china-during-2006-2014
#19
Xiaoying Chen, Zhaofan Wu, Xuecai Wang, Yue Chen, Xiaolian Dong, Jianfu Zhu, Tian Xiao, Qingwu Jiang, Chaowei Fu
OBJECTIVE: To describe the prevalence of type 2 diabetes mellitus( T2 DM) in rural Deqing County, Zhejiang Province, and explore its risk factors. METHODS: Random cluster sampling was used to select 8 rural communities in Deqing County, Zhejiang Province, and a cross-sectional survey was conducted in 2006-2008, 2011-2012 and 2013-2014, respectively. Totally, 6562 eligible subjects were investigated in 2006-2008, 11 763 eligible subjects in 2011-2012, and 10 904 eligible subjects in 2013-2014...
November 2017: Wei Sheng Yan Jiu, Journal of Hygiene Research
https://www.readbyqxmd.com/read/29902701/risk-of-peripheral-artery-disease-according-to-a-healthy-lifestyle-score-the-predimed-study
#20
Nieves López-Laguna, Miguel A Martínez-González, Estefania Toledo, Nancy Babio, José V Sorlí, Emilio Ros, Miguel Ángel Muñoz, Ramon Estruch, José Lapetra, Carlos Muñoz-Bravo, Miquel Fiol, Lluís Serra-Majem, Xavier Pintó, José I González, Montse Fitó, Josep Basora, Fernando Arós, Miguel Ruiz-Canela
BACKGROUND AND AIMS: The PREDIMED (PREvención con DIeta MEDiterránea) is a multicentre trial analyzed as a prospective cohort study. A total of 7122 participants (aged 55-80 years) at high risk of cardiovascular disease in the PREDIMED trial were recruited in 11 centres in Spain. The prevalence of subjects with type 2 diabetes was 50%. Our objective was to determine the contribution of lifestyle factors to the development of peripheral artery disease (PAD). METHODS: Incident clinical PAD in relation to a healthy lifestyle 5-point score defined as adherence to a Mediterranean diet (MedDiet), moderate alcohol intake, regular physical activity, normal weight (BMI<25) and non-smoking was measured...
May 31, 2018: Atherosclerosis
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