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Neck circumference AND insulin resistance

Shyam Verma, Resham Vasani, Rajiv Joshi, Meghana Phiske, Pritesh Punjabi, Tushar Toprani
INTRODUCTION: The term facial acanthosis nigricans (FAN) lacks definition of precise clinical and histopathological features. We present a descriptive study of patients with FAN to define pigmentary patterns and estimate the prevalence of obesity and insulin resistance in these cases. MATERIALS AND METHODS: It is a prospective study that included all patients with classical AN of the neck and/or other areas with facial acanthosis nigricans described as brown-to-black macular pigmentation with blurred ill-defined margins, found on the zygomatic and malar areas...
November 2016: Indian Dermatology Online Journal
Sara L White, Debbie A Lawlor, Annette L Briley, Keith M Godfrey, Scott M Nelson, Eugene Oteng-Ntim, Stephen C Robson, Naveed Sattar, Paul T Seed, Matias C Vieira, Paul Welsh, Melissa Whitworth, Lucilla Poston, Dharmintra Pasupathy
All obese women are categorised as being of equally high risk of gestational diabetes (GDM) whereas the majority do not develop the disorder. Lifestyle and pharmacological interventions in unselected obese pregnant women have been unsuccessful in preventing GDM. Our aim was to develop a prediction tool for early identification of obese women at high risk of GDM to facilitate targeted interventions in those most likely to benefit. Clinical and anthropometric data and non-fasting blood samples were obtained at 15+0-18+6 weeks' gestation in 1303 obese pregnant women from UPBEAT, a randomised controlled trial of a behavioural intervention...
2016: PloS One
Rasmus B Jensen, Signe H Danielsen, Anne-Helene Tauson
BACKGROUND: Obesity is related to the development of several diseases like insulin resistance and laminitis in horses. The prevalence of obesity among mature Icelandic horses in Denmark has not been investigated previously. This study aimed to find the prevalence of obesity, to compare body condition score (BCS) based on owner perception with that of an experienced person and to correlate the BCS to body weight (BW) and morphometric measures in a group of mature Icelandic horses in Denmark...
October 20, 2016: Acta Veterinaria Scandinavica
Torgrim Mikal Langleite, Jørgen Jensen, Frode Norheim, Hanne Løvdal Gulseth, Daniel Steensen Tangen, Kristoffer Jensen Kolnes, Ansgar Heck, Tryggve Storås, Guro Grøthe, Marius Adler Dahl, Anders Kielland, Torgeir Holen, Hans Jørgen Noreng, Hans Kristian Stadheim, Atle Bjørnerud, Egil Ivar Johansen, Birgitte Nellemann, Kåre Inge Birkeland, Christian A Drevon
CONTEXT: Insulin resistance and dysglycemia are associated with physical inactivity and adiposity, and may be improved by exercise. OBJECTIVE: Investigate the effect of exercise on insulin sensitivity, body composition and adipose depots in sedentary men with (n = 11) or without (n = 11) overweight and dysglycemia. MATERIAL AND METHODS: Euglycemic-hyperinsulinemic clamp, ankle-to-neck MRI, MRS, muscle and adipose tissue biopsies before and after 12 weeks combined strength and endurance exercise...
October 2016: Archives of Physiology and Biochemistry
Ernesto Maddaloni, Ilaria Cavallari, Mariangela De Pascalis, Hillary Keenan, Kyoungmin Park, Silvia Manfrini, Raffaella Buzzetti, Giuseppe Patti, Germano Di Sciascio, Paolo Pozzilli
Body circumferences have been proposed as potential anthropometric measures for the assessment of cardiometabolic risk as they are independently associated with insulin resistance and diabetes. The aim of this study was to validate neck and wrist circumference and waist-to-hip ratio as practical markers of metabolic dysfunction and atherosclerosis; 120 subjects who underwent coronary angiography and carotid Doppler ultrasound were enrolled in this cross-sectional study. Exclusion criteria were history of diabetes, acute myocardial infarction, body mass index (BMI) <18...
September 15, 2016: American Journal of Cardiology
Jun Liang, Yuting Sun, Xuekui Liu, Yan Zhu, Ying Pei, Yu Wang, Qinqin Qiu, Manqing Yang, Lu Qi
AIMS: The etiological role of obesity in determining diabetes risk among Asians may be different from that among Caucasians. The current study aimed to investigate the association between genetic predisposition to obesity and measures of insulin secretion and resistance in a large Chinese cohort. METHODS: Study samples were from a community-based health examination survey in central China. A total of 2058 subjects with available biomarkers levels were included in the present study...
September 2016: Journal of Diabetes and its Complications
Dana Prídavková, Daniela Kantárová, Renáta Lišková, Peter Červeň, František Kovář, Marián Mokáň
BACKGROUND: To assess the relationship of parameters of obesity in relationship to coronary angiography findings with correlation of epicardial fat (EF) thickness in uppermentioned context. METHODS: There were 80 patients examined (43 males, 37 postmenopausal females) undergoing elective coronary angiography. We examined the regular obesity parameters - BMI, waist circumference (WC), neck circumference (NC), total body fat (TBF), and visceral fat (VF) using bioimpedance...
April 2016: Vnitr̆ní Lékar̆ství
T Martin-Gimenez, I de Blas, E Aguilera-Tejero, E Diez de Castro, C N Aguirre-Pascasio
Equine metabolic syndrome (EMS) can be diagnosed by hormonal measurements; however, it would be important to find simpler measurements that allow easy identification of affected or at risk individuals. In horses, the dorsal neck region is one of the most frequent anatomical sites for fat deposition and neck obesity has been linked to EMS. The aim of this study was to evaluate the association of hormonal markers of obesity (leptin) and insulin resistance (insulin) with morphometric and ultrasonographic neck measurements in Andalusian horses...
July 2016: Domestic Animal Endocrinology
Yavor Assyov, Antoaneta Gateva, Adelina Tsakova, Zdravko Kamenov
: Purpose/Aim: Neck circumference (NC) is an emerging anthropometric parameter that has been proposed to reflect metabolic health. The aim of the current study was to compare its clinical usefulness to waist circumference (WC) in the assessment of individuals with severe obesity. MATERIALS AND METHODS: A total of 255 subjects participated in the study. All anthropometric measurements were done by a single medical professional. Biochemical measurements included oral glucose-tolerance tests (OGTTs), fasting insulin, lipids, and hepatic enzymes...
April 6, 2016: Endocrine Research
Ana Maria De Bernardi Rodrigues, Cleliani de Cassia da Silva, Ana Carolina Junqueira Vasques, Daniella Fernandes Camilo, Francieli Barreiro, Roberta Soares Lara Cassani, Mariana Porto Zambon, Maria Ângela Reis de Góes Monteiro Antonio, Bruno Geloneze
IMPORTANCE: The association between short sleep duration and decreased insulin sensitivity in adolescents has been described. However, to our knowledge, no studies have investigated this association measuring insulin sensitivity by the hyperglycemic clamp technique. OBJECTIVES: To compare the distributions of parameters of insulin resistance in adolescents with sleep deprivation vs adequate sleep, and to investigate the association between sleep deprivation and insulin sensitivity...
May 1, 2016: JAMA Pediatrics
Zhe Pan, Xianghua Zhuang, Xiaobo Li, Shaoyi Huang, Liang Zhang, Fuchen Lou, Shihong Chen, Yihong Ni
Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a commonly-diagnosed chronic sleep disorder. It is considered to be an important independent risk factor in the development of insulin resistance (IR). Patients with OSAHS exhibit a variety of metabolic disorders, including obesity and metabolic syndrome. Visceral adipose tissue-derived serpin (vaspin) is an adipokine that is considered to be a link between obesity and IR. The present study aimed to evaluate the levels of plasma vaspin in patients with OSAHS and examine their potential correlation with sleep characteristics...
March 2016: Experimental and Therapeutic Medicine
Diego Gomez-Arbelaez, Paul Anthony Camacho, Daniel Dylan Cohen, Sandra Saavedra-Cortes, Cristina Lopez-Lopez, Patricio Lopez-Jaramillo
BACKGROUND: The current study aims to evaluate the association between neck circumference (NC) and several cardio-metabolic risk factors, to compare it with well-established anthropometric indices, and to determine the cut-off point value of NC for predicting children at increased risk of metabolic syndrome, insulin resistance and low-grade systemic inflammation. METHODS: A total of 669 school children, aged 8-14, were recruited. Demographic, clinical, anthropometric and biochemical data from all patients were collected...
March 8, 2016: BMC Pediatrics
Cristina P Baena, Paulo A Lotufo, Maria G M Fonseca, Itamar S Santos, Alessandra C Goulart, Isabela M J Benseñor
BACKGROUND: Neck circumference (NC) is a simple anthropometric measurement that may be linked with cardiometabolic risk factors. We analyzed the association between NC and a range of cardiometabolic risk factors. METHODS: In a cross-sectional and sex-specific analysis of the ELSA-Brasil study (15,105 civil servants aged 35-74 years), we excluded participants with diabetes, taking antihypertensive and/or lipid-lowering drugs. Cardiometabolic risk factors were homeostasis model assessment of insulin resistance (≥ 75th percentile), low high-density lipoprotein (HDL; <50 mg/dL for women and <40 mg/dL for men), high triglycerides ≥ 150 mg/dL, systolic blood pressure ≥ 130 mmHg, or diastolic blood pressure ≥ 85 mmHg...
April 2016: Metabolic Syndrome and related Disorders
Nils Eckstein, Nikolaus Buchmann, Ilja Demuth, Elisabeth Steinhagen-Thiessen, Jivko Nikolov, Dominik Spira, Rahel Eckardt, Kristina Norman
BACKGROUND: Decreased bone mineral density (BMD) has been linked to metabolic disorders, such as type 2 diabetes. However, results regarding the metabolic syndrome (MetS), a cluster of at least 3 of 5 cardiovascular risk parameters with potentially contradictory effects on BMD are still inconclusive. OBJECTIVE: We investigated the effect of MetS and its single parameters on BMD at 3 sites in community-dwelling older subjects. METHODS: 1,402 subjects (51...
2016: Gerontology
Nam H Cho, Tae Jung Oh, Kyoung Min Kim, Sung Hee Choi, Jae Ho Lee, Kyong Soo Park, Hak Chul Jang, Jong Yeol Kim, Hong Kyu Lee, Soo Lim
Neck circumference, a proxy for upper-body fat, may be a unique fat depot that indicates metabolic risk beyond whole body fat. We investigated whether neck circumference is associated with development of diabetes mellitus (DM) in a subset of data with Korean Genome and Epidemiology Study (n = 3521, age range = 42-71 years). Nondiabetic subjects at the baseline were categorized into 4 groups (Q1-Q4) according to their neck circumference. Parameters related with β-cell function and insulin resistance including Epworth sleepiness scale and snoring habit were examined...
December 18, 2015: Scientific Reports
Luciene da Silva Araújo, Julia Freitas Rodrigues Fernandes, Márcia Regina Simas Torres Klein, Antonio Felipe Sanjuliani
OBJECTIVES: Obstructive sleep apnea (OSA) is associated with an increased risk of cardiovascular disease (CVD). Several of the proposed mechanisms for the development of CVD in OSA are similar to those proposed for the increased risk of CVD in obesity, so that it is difficult to determine the influence of OSA on these pathogenic mechanisms in obese individuals. The aim of this study was to evaluate the relationship of OSA with endothelial function, oxidative stress, inflammatory biomarkers, metabolic profile, sympathetic nervous system activity, and blood pressure (BP) in obese individuals...
November 2015: Nutrition
Mawaddah Azman, Abdullah Sani, Nor Azmi Kamaruddin
BACKGROUND AND OBJECTIVES: Obstructive sleep apnea (OSA) is a common disease affecting middle-aged patients and is associated with significant cardiovascular, cerebrovascular, and metabolic complications. Current evidences show inconclusive association between OSA and insulin resistance (IR). This study aims to examine the possible correlation between OSA parameters and IR. DESIGN AND SETTINGS: This was a cross-sectional study to examine the association between OSA parameters and IR using homeostasis model assessment (HOMA) on patients who underwent polysomnogram (PSG) in a tertiary center between March 2011 and March 2012 (1 year)...
November 2014: Annals of Saudi Medicine
Raquel Munhoz da Silveira Campos, Ana Raimunda Dâmaso, Deborah Cristina Landi Masquio, Antonio Eduardo Aquino, Marcela Sene-Fiorese, Fernanda Oliveira Duarte, Lian Tock, Nivaldo Antonio Parizotto, Vanderlei Salvador Bagnato
Recently, investigations suggest the benefits of low-level laser (light) therapy (LLLT) in noninvasive treatment of cellulite, improvement of body countering, and control of lipid profile. However, the underlying key mechanism for such potential effects associated to aerobic plus resistance training to reduce body fat and inflammatory process, related to obesity in women still unclear. The purpose of the present investigation was to evaluate the effects of combined therapy of LLLT and aerobic plus resistance training in inflammatory profile and body composition of obese women...
July 2015: Lasers in Medical Science
Shaimaa Selim, Kari Elo, Seija Jaakkola, Ninja Karikoski, Ray Boston, Tiina Reilas, Susanna Särkijärvi, Markku Saastamoinen, Tuomo Kokkonen
Obesity and insulin resistance have been shown to be risk factors for laminitis in horses. The objective of the study was to determine the effect of changes in body condition during the grazing season on insulin resistance and the expression of genes associated with obesity and insulin resistance in subcutaneous adipose tissue (SAT). Sixteen Finnhorse mares were grazing either on cultivated high-yielding pasture (CG) or semi-natural grassland (NG) from the end of May to the beginning of September. Body measurements, intravenous glucose tolerance test (IVGTT), and neck and tailhead SAT gene expressions were measured in May and September...
2015: PloS One
Satomi Aoi, Takashi Miyake, Toshihide Harada, Fumiko Ishizaki, Hiromi Ikeda, Yumiko Nitta, Tadayuki Iida, Chiho Chikamura, Noriko Tamura, Kohsaku Nitta, Hideki Miyaguchi
Subcutaneous fat depots play an important role in regulating metabolic profile in Japanese postmenopausal women. We investigated the possibility of neck circumference (NC) as a surrogate marker for metabolic disease risk estimates in Japanese postmenopausal women. We examined the association of NC with several markers of insulin resistance, lipid metabolism and atherosclerosis in 64 healthy postmenopausal women aged 63.6 ± 7.1 years in community-based samples in Japan. As a result, NC was significantly associated with indices of whole body obesity and visceral fat accumulation, such as body mass index (BMI) and Waist circumference (WC)...
December 2014: Hiroshima Journal of Medical Sciences
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