keyword
https://read.qxmd.com/read/38463293/in-silico-structural-modeling-and-binding-site-analysis-of-cerebroside-sulfotransferase-cst-a-therapeutic-target-for-developing-substrate-reduction-therapy-for-metachromatic-leukodystrophy
#21
JOURNAL ARTICLE
Nivedita Singh, Anil Kumar Singh
Cerebroside sulfotransferase (CST) is emerging as an important therapeutic target to develop substrate reduction therapy (SRT) for metachromatic leukodystrophy (MLD), a rare neurodegenerative lysosomal storage disorder. MLD develops with progressive impairment and destruction of the myelin sheath as a result of accumulation of sulfatide around the nerve cells in the absence of its recycling mechanism with deficiency of arylsulfatase A (ARSA). Sulfatide is the product of the catalytic action of cerebroside sulfotransferase (CST), which needs to be regulated under pathophysiological conditions by inhibitor development...
March 5, 2024: ACS Omega
https://read.qxmd.com/read/38458259/european-association-of-urology-risk-stratification-predicts-outcome-in-patients-receiving-psma-pet-planned-salvage-radiotherapy-for-biochemical-recurrence-following-radical-prostatectomy
#22
JOURNAL ARTICLE
Sophia Scharl, Constantinos Zamboglou, Iosif Strouthos, Andrea Farolfi, Francesca Serani, Stefan A Koerber, Jürgen Debus, Jan C Peeken, Marco M E Vogel, Stephanie G C Kroeze, Matthias Guckenberger, Manuel Krafcsik, George Hruby, Louise Emmett, Nina-Sophie Schmidt-Hegemann, Christian Trapp, Simon K B Spohn, Christoph Henkenberens, Benjamin Mayer, Mohamed Shelan, Daniel M Aebersold, Reinhard Thamm, Thomas Wiegel
PURPOSE: The European Association of Urology (EAU) proposed a risk stratification (high vs. low risk) for patients with biochemical recurrence (BR) following radical prostatectomy (RP). Here we investigated whether this stratification accurately predicts outcome, particularly in patients staged with PSMA-PET. METHODS: For this study, we used a retrospective database including 1222 PSMA-PET-staged prostate cancer patients who were treated with salvage radiotherapy (SRT) for BR, at 11 centers in 5 countries...
March 6, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38454597/a-systematic-review-of-case-series-and-clinical-trials-investigating-systemic-oral-or-injectable-therapies-for-the-treatment-of-vitiligo
#23
REVIEW
Alireza Jafarzadeh, Arash Pour Mohammad, Mina Khosravi, Shila Amiri, Asma Rasouli, Haniyeh Keramati, Azadeh Goodarzi
AIMS AND OBJECTIVES: The purpose of this study is to investigate the effectiveness and safety of oral and injectable systemic treatments, such as methotrexate, azathioprine, cyclosporine, tofacitinib, baricitinib, corticosteroids, statins, zinc, apremilast, etc., for treating vitiligo lesions. METHOD: Databases including PubMed, Scopus, and Web of Science were meticulously searched for studies spanning from 2010 to August 2023, focusing on systemic oral and injectable therapies for vitiligo, using comprehensive keywords and search syntaxes tailored to each database...
March 2024: Skin Research and Technology
https://read.qxmd.com/read/38454571/mir-200c-3p-as-a-novel-genetic-marker-and-therapeutic-tool-for-alopecia-areata
#24
JOURNAL ARTICLE
Ahmed Ibrahim AbdElneam, Mohammed Saleh Al-Dhubaibi, Saleh Salem Bahaj, Ghadah Alhetheli
BACKGROUND: MicroRNAs (miRNAs) are small RNA molecules that regulate gene expression in diverse biological processes. They hold promise as therapeutic candidates for targeting human disease pathways, although our understanding of their gene regulatory mechanism remains incomplete. Alopecia areata (AA) is a prevalent inflammatory ailment distinguished by the infiltration of T cells targeting the anagen-stage hair follicles. The scarcity of effective remedies for AA may stem from limited understanding regarding its precise cellular mechanism...
March 2024: Skin Research and Technology
https://read.qxmd.com/read/38454567/exploring-mitochondrial-metabolism-of-wild-type-and-diabetic-mice-skin-explants-using-the-seahorse-technology
#25
JOURNAL ARTICLE
Justine Dugrain, Laurence Canaple, Nicolas Picard, Dominique Sigaudo-Roussel, Christelle Bonod
BACKGROUND: Skin wound healing is a complex mechanism which requires a lot of energy, mainly provided by mitochondrial respiration. However, little is known about the mitochondrial bioenergetics of mice skin. We sought to develop a microplate-based assay to directly measure oxygen consumption in whole mice skin with the goal of identifying mitochondrial dysfunction in diabetic skin using an extracellular flux. MATERIALS AND METHODS: Different parameters were optimized to efficiently measure the oxygen consumption rate (OCR)...
March 2024: Skin Research and Technology
https://read.qxmd.com/read/38454281/insertion-results-and-hearing-outcomes-of-a-slim-lateral-wall-electrode
#26
JOURNAL ARTICLE
Sini Sipari, Matti Iso-Mustajärv, Pia Linder, Aarno Dietz
BACKGROUND: The clinical outcomes of cochlear implantation vary for several reasons. It is necessary to study the different electrodes and variables for further development. The aim of this study is to report the clinical outcomes of a new slim lateral wall electrode (SlimJ). METHODS: Data of 25 cochlear implantations in 23 patients with the SlimJ electrode were retrospectively collected. The insertion results were assessed by image fusion of the preoperative computed tomography (CT), magnetic resonance imaging (MRI), and postoperative cone-beam CT...
January 2024: Journal of International Advanced Otology
https://read.qxmd.com/read/38450079/clinical-characteristics-and-lateralization-of-the-horizontal-semicircular-canal-light-cupula
#27
JOURNAL ARTICLE
Wenjing Qin, Zheng Liu, Yanhan Zhu, Xueyan Zhang, Jiao Xu, Tao Zhou, Lingli Wei, Yi Fang, Liying Chang
INTRODUCTION: Positional vertigo and nystagmus are the main symptoms and signs of dizziness, respectively. Despite the clinical utility of the supine roll test (SRT) and null point (NP) in diagnosing light cupula, a type of positional vertigo, there exists a notable gap in the literature concerning the comprehensive evaluation of lateralization values based on various nystagmus characteristics and the intensity of direction-changing positional nystagmus (DCPN) in the SRT, particularly in comparison to the NP...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38446199/real-world-experience-of-using-stereotactic-radiotherapy-combined-with-anti-vascular-endothelial-growth-factor-to-treat-neovascular-amd
#28
JOURNAL ARTICLE
Rosalind Creer, Nattapon Boonarpha, Gemma Gould, Azita Rajai, Ramandeep Chhabra
INTRODUCTION: Adjunctive treatment or longer-acting drugs are required to treat nAMD to help ease burdens for patients and hospital clinics alike. Stereotactic therapy is one such option, providing a reduction in the number of injections over time. OBJECTIVE: To determine the clinical outcomes in a cohort of patients with nAMD receiving a combination therapy of stereotactic radiotherapy (SRT) with intravitreal anti-VEGF injections (IVI). METHOD: A retrospective analysis of 74 patients with nAMD, who had received IVI and SRT (16 Gray maximum dose to the macula) at a large tertiary university eye hospital, between March 2018 and September 2019 was performed...
March 6, 2024: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/38445788/disordered-spatial-pattern-of-redness-signal-on-facial-skin-and-visual-perception-of-health-stress-and-hidden-aging
#29
JOURNAL ARTICLE
Tatsuya Omotezako, Eleanor Neo, Hong Zhu, Matthew Eharman
BACKGROUND: Well-being is commonly communicated across industries; however, experimental understanding how human perceive skin health and skin stresses are not sufficient. MATERIALS AND METHODS: Image analysis algorithm, a* gradient, was developed to evaluate spatial pattern and shape of red signal on skin. Human perception for skin health and stresses were compared with technical measurements in two visual perception studies. RESULTS: a* gradient correlated with perceived Inflamed Skin (R = 0...
March 2024: Skin Research and Technology
https://read.qxmd.com/read/38444188/horizontal-necklines-correction-with-absorbable-braided-polydioxanone-threads-case-series
#30
JOURNAL ARTICLE
Kyu-Ho Yi, Soo-Bin Kim, Deborah Chua, Matthieu Beustes Stefanelli, Michael Alfertshofer, Vasanop Vachiramon
INTRODUCTION: The prevalence of horizontal neck lines as a cosmetic concern is widely acknowledged, yet the available treatment options are limited, and no studies have investigated the use of polydioxanone-barbed threads. These threads, characterized by a finely braided structure, function as a scaffold to attract regenerative factors and facilitate the migration and proliferation of cells. This study aims to evaluate the outcomes of concurrent application of braided polydioxanone-barbed threads for addressing horizontal neck wrinkles...
March 2024: Skin Research and Technology
https://read.qxmd.com/read/38440045/prognostic-significance-of-the-cachexia-index-in-patients-with-non-small-cell-lung-cancer-and-brain-metastases-after-stereotactic-radiotherapy
#31
JOURNAL ARTICLE
Hui Xu, Bin Zhang, Yongqian Zhang, Chunchun Yang, Changwen Bo, Yuanyuan Guo, Yuan Cheng, Li He
BACKGROUND: The cachexia index (CXI) has been proposed as a novel biomarker of cancer cachexia. We aimed to investigate the association between CXI and survival outcomes after stereotactic radiotherapy (SRT) in patients with non-small cell lung cancer (NSCLC) and brain metastases. METHODS: Data from 145 patients with NSCLC, who underwent SRT for brain metastases between April 2016 and August 2020, were retrospectively analyzed. Cachexia index was calculated as skeletal muscle index (SMI) × serum albumin level/neutrophil-to-lymphocyte ratio, whereas SMI was calculated from computed tomography images captured at the L1 level...
2024: Clinical Medicine Insights. Oncology
https://read.qxmd.com/read/38426414/exploration-of-the-causality-of-frailty-index-on-psoriasis-a-mendelian-randomization-study
#32
JOURNAL ARTICLE
Hao Lei, Zixuan Xing, Xin Chen, Yilin Dai, Baochen Cheng, Shengbang Wang, Tong Kang, Qian Wang, Jing Zhang, Jinjing Jia, Yan Zheng
BACKGROUND: Frailty is associated with a variety of diseases, but the relationship between frailty and psoriasis remains unclear. METHODS: First, we conducted a two-sample Mendelian randomization based on genome-wide association studies (GWAS) to investigate genetic causality between frailty index and common diseases in dermatology. Inverse variance weighted was used to estimate causality. Second, expression quantitative trait locus (eQTLs) analysis was conducted to identify the genes affected by Single nucleotide polymorphisms (SNPs)...
March 2024: Skin Research and Technology
https://read.qxmd.com/read/38426391/investigation-of-the-risk-factors-in-the-development-of-radionecrosis-in-patients-with-brain-metastases-undergoing-stereotactic-radiotherapy
#33
JOURNAL ARTICLE
Bedriye Doğan, Harun Demir, Naciye Işık, Gun Gunalp, Hediye Pınar Günbey, Gökhan Yaprak
OBJECTIVE: To investigate the incidence, timing and the factors predictors radionecrosis (RN) development in brain metastases (BMs) undergoing stereotactic radiotherapy (SRT). METHODS: The study evaluated 245 BMs who exclusively received SRT between 2010 and 2020. RN was detected pathologically or radiologically. RESULTS: The median of follow-up was 22.6 months. RN was detected in 18.4% of the metastatic lesions, and 3.3% symptomatic, 15...
February 29, 2024: British Journal of Radiology
https://read.qxmd.com/read/38425474/exploring-bradyphrenia-in-huntington-s-disease-using-the-computerized-test-of-information-processing-ctip
#34
JOURNAL ARTICLE
Georgia M Parkin, Braden Culbert, Emma Churchill, Paul E Gilbert, Jody Corey-Bloom
BACKGROUND: Bradyphrenia, best thought of as the mental equivalent of bradykinesia, has been described in several disorders of the brain including Parkinson's disease and schizophrenia; however, little is known about this phenomenon in Huntington's Disease (HD). OBJECTIVE: The aim of this study was to investigate the presence of bradyphrenia in HD using the Computerized Test of Information Processing (CTiP), an easy to administer and objective task that assesses cognitive processing speed with increasing task complexity...
2024: Clinical parkinsonism & related disorders
https://read.qxmd.com/read/38424730/quality-of-life-sleep-and-anxiety-status-among-patients-with-rosacea-in-the-yunnan-plateau-region-a-2-year-retrospective-study
#35
JOURNAL ARTICLE
Zhenghui Yang, Wei Zhao, Min Hu, Pan Wu, Xin Zhang, Tingyu Wang, Qiuyan Yao, Piyan Hua, Hua Gu
OBJECTIVE: To investigate the life, sleep quality and anxiety of rosacea patients in Yunnan and the improvement of these aspects after treatment. METHODS: A total of 141 patients with rosacea and 123 healthy controls were included in our study. The quality of life, sleep quality and anxiety of patients with rosacea and healthy controls were investigated by the Rosacea Severity Scores (RSSs), the Medical Outcomes Study 36-item short-form health survey (SF-36), the Pittsburgh Sleep Quality Index (PSQI) and Self-rating Anxiety Scale (SAS)...
March 2024: Skin Research and Technology
https://read.qxmd.com/read/38424726/genetic-insights-into-the-gut-microbiota-and-risk-of-facial-skin-aging-a-mendelian-randomization-study
#36
JOURNAL ARTICLE
Mulan Chen, Yuhui Che, Mengsong Liu, Xinyu Xiao, Lin Zhong, Siqi Zhao, Xueer Zhang, Anjing Chen, Jing Guo
BACKGROUND: A growing number of experimental studies have shown an association between the gut microbiota (GM) and facial skin aging. However, the causal relationship between GM and facial skin aging remains unclear to date. METHODS: We conducted a two-sample Mendelian randomization (MR) analysis to investigate the potential causal relationship between GM and facial skin aging. MR analysis was mainly performed using the inverse-variance weighting (IVW) method, complemented by the weighted median (MW) method, MR-Egger regression, and weighted mode, and sensitivity analysis was used to test the reliability of MR analysis results...
March 2024: Skin Research and Technology
https://read.qxmd.com/read/38422628/the-effect-of-spiritual-reminiscence-therapy-on-depression-and-hope-among-iranian-older-adults-a-quasi-experimental-study
#37
JOURNAL ARTICLE
Milad Bazghaleh, Ruhollah Farsi, Saeed Ghasempour, Mohammad Hasan Basirinezhad, Ahmad Khosravi, Ali Abbasi
This quasi-experimental study aimed to evaluate the impact of spiritual reminiscence therapy (SRT) on depression and hope among older adults living in Shahroud, northeast of Iran. One hundred fifty-six older adults were selected through convenience sampling and assigned non-randomly to the intervention (n= 78) and control (n= 78) groups. The data collection tools included the Geriatric Depression Scale and Adult Hope Scale. For the intervention group, SRT was conducted in six weekly sessions, each lasting 60 to 90 min, over six weeks...
February 28, 2024: Geriatric Nursing
https://read.qxmd.com/read/38419420/skinly-a-novel-handheld-iot-device-for-validating-biophysical-skin-characteristics
#38
JOURNAL ARTICLE
Maria Del Pilar Bonilla Tobar, Sven Clemann, Ralf Hagens, Sonja Pagel-Wolff, Stefan Hoppe, Peter Behm, Felicia Engelhard, Maria Langhals, Stefan Gallinat, Alex Zhavoronkov, Anastasia Georgievskaya, Konstantin Kiselev, Timur Tlyachev, Sören Jaspers
BACKGROUND: Recent advancements in artificial intelligence have revolutionized dermatological diagnostics. These technologies, particularly machine learning (ML), including deep learning (DL), have shown accuracy equivalent or even superior to human experts in diagnosing skin conditions like melanoma. With the integration of ML, including DL, the development of at home skin analysis devices has become feasible. To this end, we introduced the Skinly system, a handheld device capable of evaluating various personal skin characteristics noninvasively...
March 2024: Skin Research and Technology
https://read.qxmd.com/read/38419415/evaluation-of-the-anti-aging-effects-of-zinc-%C3%AE-2-glycoprotein-peptide-in-clinical-and-in-vitro-study
#39
JOURNAL ARTICLE
Sang Gyu Lee, Seoyoon Ham, Joohee Lee, Yujin Jang, Jangmi Suk, Young In Lee, Ju Hee Lee
BACKGROUND: Skin aging, characterized by the deterioration of skin density and elasticity, is a common concern among individuals seeking to maintain a youthful appearance. Zinc-α2-glycoprotein (ZAG) is secreted by various body fluids, and is associated with lipolysis and identified as an atopic dermatitis biomarker. This study evaluated the potential of ZAG peptides, which exert multiple benefits such as anti-aging. MATERIALS AND METHODS: We conducted a 4-week clinical trial on patients with noticeable periorbital wrinkles (n = 22) using a ZAG peptide-containing product...
March 2024: Skin Research and Technology
https://read.qxmd.com/read/38418029/srt-swin-residual-transformer-for-benign-and-malignant-nodules-classification-in-thyroid-ultrasound-images
#40
JOURNAL ARTICLE
Long Huang, Yanran Xu, Shuhuan Wang, Liang Sang, He Ma
With the advancement of deep learning technology, computer-aided diagnosis (CAD) is playing an increasing role in the field of medical diagnosis. In particular, the emergence of Transformer-based models has led to a wider application of computer vision technology in the field of medical image processing. In the diagnosis of thyroid diseases, the diagnosis of benign and malignant thyroid nodules based on the TI-RADS classification is greatly influenced by the subjective judgment of ultrasonographers, and at the same time, it also brings an extremely heavy workload to ultrasonographers...
February 2024: Medical Engineering & Physics
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