keyword
https://read.qxmd.com/read/38491270/benchmarking-spatial-clustering-methods-with-spatially-resolved-transcriptomics-data
#1
JOURNAL ARTICLE
Zhiyuan Yuan, Fangyuan Zhao, Senlin Lin, Yu Zhao, Jianhua Yao, Yan Cui, Xiao-Yong Zhang, Yi Zhao
Spatial clustering, which shares an analogy with single-cell clustering, has expanded the scope of tissue physiology studies from cell-centroid to structure-centroid with spatially resolved transcriptomics (SRT) data. Computational methods have undergone remarkable development in recent years, but a comprehensive benchmark study is still lacking. Here we present a benchmark study of 13 computational methods on 34 SRT data (7 datasets). The performance was evaluated on the basis of accuracy, spatial continuity, marker genes detection, scalability, and robustness...
March 15, 2024: Nature Methods
https://read.qxmd.com/read/38488902/degro-guideline-for-personalized-radiotherapy-of-brain-metastases-and-leptomeningeal-carcinomatosis-in-patients-with-breast-cancer
#2
REVIEW
Kai J Borm, Sophie T Behzadi, Juliane Hörner-Rieber, David Krug, Rene Baumann, Stefanie Corradini, Marciana Nona Duma, Jürgen Dunst, Gerd Fastner, Petra Feyer, Rainer Fietkau, Wulf Haase, Wolfgang Harms, Thomas Hehr, Christiane Matuschek, Marc D Piroth, Leonard Christopher Schmeel, Rainer Souchon, Vratislav Strnad, Wilfried Budach, Stephanie E Combs
PURPOSE: The aim of this review was to evaluate the existing evidence for radiotherapy for brain metastases in breast cancer patients and provide recommendations for the use of radiotherapy for brain metastases and leptomeningeal carcinomatosis. MATERIALS AND METHODS: For the current review, a PubMed search was conducted including articles from 01/1985 to 05/2023. The search was performed using the following terms: (brain metastases OR leptomeningeal carcinomatosis) AND (breast cancer OR breast) AND (radiotherapy OR ablative radiotherapy OR radiosurgery OR stereotactic OR radiation)...
March 15, 2024: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://read.qxmd.com/read/38488420/n95-respirators-alter-facial-skin-physiological-functions-and-lipidome-composition-in-health-care-personnel
#3
JOURNAL ARTICLE
Min Li, Feifei Wang, Meng Tao, Yue Zhang, Ruoxin Pan, Duoduo Gu, Hui Zhong, Yang Xu
BACKGROUND: During the coronavirus disease 2019 pandemic, wearing medical respirators and masks was essential to prevent transmission. OBJECTIVE: To quantify the effects of N95 mask usage by measuring facial skin biophysical characteristics and changes in the lipidome. METHODS: Sixty healthy volunteers wore N95 respirators for 3 or 6 h. Facial images were acquired and physiological parameters were measured in specific facial areas, before and after mask-wearing...
March 2024: Skin Research and Technology
https://read.qxmd.com/read/38487801/spaco-a-comprehensive-tool-for-coloring-spatial-data-at-single-cell-resolution
#4
JOURNAL ARTICLE
Zehua Jing, Qianhua Zhu, Linxuan Li, Yue Xie, Xinchao Wu, Qi Fang, Bolin Yang, Baojun Dai, Xun Xu, Hailin Pan, Yinqi Bai
Understanding tissue architecture and niche-specific microenvironments in spatially resolved transcriptomics (SRT) requires in situ annotation and labeling of cells. Effective spatial visualization of these data demands appropriate colorization of numerous cell types. However, current colorization frameworks often inadequately account for the spatial relationships between cell types. This results in perceptual ambiguity in neighboring cells of biological distinct types, particularly in complex environments such as brain or tumor...
March 8, 2024: Patterns
https://read.qxmd.com/read/38483979/automated-speech-audiometry-can-it-work-using-open-source-pre-trained-kaldi-nl-automatic-speech-recognition
#5
JOURNAL ARTICLE
Gloria Araiza-Illan, Luke Meyer, Khiet P Truong, Deniz Başkent
A practical speech audiometry tool is the digits-in-noise (DIN) test for hearing screening of populations of varying ages and hearing status. The test is usually conducted by a human supervisor (e.g., clinician), who scores the responses spoken by the listener, or online, where software scores the responses entered by the listener. The test has 24-digit triplets presented in an adaptive staircase procedure, resulting in a speech reception threshold (SRT). We propose an alternative automated DIN test setup that can evaluate spoken responses whilst conducted without a human supervisor, using the open-source automatic speech recognition toolkit, Kaldi-NL...
2024: Trends in Hearing
https://read.qxmd.com/read/38483255/deep-learning-in-spatially-resolved-transcriptfomics-a-comprehensive-technical-view
#6
JOURNAL ARTICLE
Roxana Zahedi, Reza Ghamsari, Ahmadreza Argha, Callum Macphillamy, Amin Beheshti, Roohallah Alizadehsani, Nigel H Lovell, Mohammad Lotfollahi, Hamid Alinejad-Rokny
Spatially resolved transcriptomics (SRT) is a pioneering method for simultaneously studying morphological contexts and gene expression at single-cell precision. Data emerging from SRT are multifaceted, presenting researchers with intricate gene expression matrices, precise spatial details and comprehensive histology visuals. Such rich and intricate datasets, unfortunately, render many conventional methods like traditional machine learning and statistical models ineffective. The unique challenges posed by the specialized nature of SRT data have led the scientific community to explore more sophisticated analytical avenues...
January 22, 2024: Briefings in Bioinformatics
https://read.qxmd.com/read/38483051/effectiveness-safety-and-patient-satisfaction-of-carboxytherapy-as-an-adjunctive-treatment-for-periorbital-hyperpigmentation
#7
JOURNAL ARTICLE
Farnoosh Seirafianpour, Najmolsadat Atefi, Nazila Ghoreishi Amin, Mohammad Reza Namazi, Elham Behrangi, Aboozar Shafiei, Mohammadreza Ghassemi, Samaneh Mozafarpoor, Azadeh Goodarzi
INTRODUCTION: Dark under-eye circles or periorbital hyperpigmentation constitute a prevalent and challenging cosmetic problem with diverse etiologies and types. While modifying exacerbating habits can provide partial relief for the pigmentary and vascular factors associated with this condition, and despite the abundance of available treatment options, there is currently a lack of gold-standard evidence-based treatments proposed for curing this disorder. OBJECTIVES: This study aimed to assess the safety and effectiveness of carboxytherapy in treating periorbital hyperpigmentation...
March 2024: Skin Research and Technology
https://read.qxmd.com/read/38482979/a-histone-deacetylase-fasrt1-2-plays-multiple-roles-in-regulating-fruit-ripening-plant-growth-and-stresses-resistance-of-cultivated-strawberry
#8
JOURNAL ARTICLE
Liangxin Wang, Yuanxiu Lin, Guoyan Hou, Min Yang, Yuting Peng, Yuyan Jiang, Caixia He, Musha She, Qing Chen, Mengyao Li, Yong Zhang, Yunting Zhang, Yan Wang, Wen He, Xiaorong Wang, Haoru Tang, Ya Luo
Sirtuins (SRTs) are a group of nicotinamide adenine dinucleotide (NAD+ )-dependent deacetylase that target both histone and nonhistone proteins. The biological function of SRT in horticultural plants has been rarely studied. In this study, FaSRT1-2 was identified as a key member of the 8 FaSRTs encoded in cultivated strawberry genome. Transient overexpression of FaSRT1-2 in strawberry fruit accelerated ripening, increased the content of anthocyanins and sugars, enhanced ripening-related gene expression. Moreover, stable transformation of FaSRT1-2 in strawberry plants resulted in enhanced vegetative growth, increased sensitivity to heat stress and increased susceptibility to Botrytis cinerea infection...
March 14, 2024: Plant, Cell & Environment
https://read.qxmd.com/read/38481087/establishment-and-verification-of-a-method-for-analyzing-nasal-blackheads-images
#9
JOURNAL ARTICLE
Hua Sun, GuanSheng Yang, Jing Yuan, Yanwen Jiang, Gang Jin
BACKGROUND: As people pay more attention to their skin health and the demand of developing skin care products for facial blackheads grows, the value of objective and efficient image recognition methods for blackheads is becoming more evident. Inspired by this current situation, this study attempted to analyze the number of blackheads of different severity automatically on the nose using an object recognition method on photographs of the nasal blackheads of subjects. METHOD: This study collected 350 subjects' facial photos in the laboratory environment, who aged 18-60, with blackhead symptoms in the nasal region...
March 2024: Skin Research and Technology
https://read.qxmd.com/read/38481085/penetration-rates-into-the-stratum-corneum-layer-a-novel-quantitative-indicator-for-assessing-skin-barrier-function
#10
JOURNAL ARTICLE
Suji Yoo, Jongwook Kim, Eui Taek Jeong, Seung Jin Hwang, Nae-Gyu Kang, Jinyong Lee
BACKGROUND: The stratum corneum (SC), the outermost layer of the skin epidermis, acts as an effective bi-directional barrier, preventing water loss (inside-outside barrier) and entry of foreign substances (outside-inside barrier). Although transepidermal water loss (TEWL) is a widely-used measure of barrier function, it represents only inside-outside protection. Therefore, we aimed to establish a non-invasive method for quantitative evaluation of the outside-inside barrier function and visually present a skin barrier model...
March 2024: Skin Research and Technology
https://read.qxmd.com/read/38481080/oral-consumption-of-bonito-fish-derived-elastin-peptide-vgpg-elastin-%C3%A2-improves-biophysical-properties-in-aging-skin-a-randomized-double-blinded-placebo-controlled-study
#11
JOURNAL ARTICLE
Seol Hwa Seong, Young In Lee, Joohee Lee, Jangmi Suk, In Ah Kim, Chaemin Baeg, Jinhak Kim, Ju Hee Lee
BACKGROUND: Recent in vitro and in vivo studies have suggested that the elastin peptide improves the skin's biophysical properties, enhancing the proliferation of fibroblasts and elastin synthesis, resulting in anti-aging properties. Therefore, we conducted a randomized, double-blinded, placebo-controlled study to clinically evaluate the effect of elastin peptide intake on human skin. MATERIALS AND METHODS: Healthy adult participants (N = 100) were randomly assigned to receive a test product containing 100 mg of Bonito elastin peptide (VGPG Elastin® ) or placebo...
March 2024: Skin Research and Technology
https://read.qxmd.com/read/38481069/skin-boosters-definitions-and-varied-classifications
#12
REVIEW
Kyu-Ho Yi, Waranaree Winayanuwattikun, Sung-Yeon Kim, Jovian Wan, Vanravi Vachatimanont, Ardhiah Iswanda Putri, Inneke Jane Hidajat, Yuri Yogya, Ruri Pamela
BACKGROUND: The concept of "skin boosters" has evolved, marking a shift from traditional uses of hyaluronic acid (HA) fillers primarily for augmenting skin volume to a more diverse application aimed at improving dermal conditions. Restylane Vital and other HA fillers have been repurposed to combat skin aging and wrinkles by delivering HA directly to the dermis. OBJECTIVES: This review aims to define the term "skin booster" and to discuss the various components that constitute skin boosters...
March 2024: Skin Research and Technology
https://read.qxmd.com/read/38477370/multimodal-prehabilitation-in-elective-oncological-colorectal-surgery-enhances-preoperative-physical-fitness-a-single-center-prospective-real-world-data-analysis
#13
JOURNAL ARTICLE
David W G Ten Cate, Charissa R Sabajo, Charlotte J L Molenaar, Loes Janssen, Bart C Bongers, Gerrit D Slooter
BACKGROUND: Surgery can lead to curation in colorectal cancer (CRC) but is associated with significant morbidity. Prehabilitation plays an important role in increasing preoperative physical fitness to reduce morbidity risk; however, data from real-world practice is scarce. This study aimed to evaluate the change in preoperative physical fitness and to evaluate which patients benefit most from prehabilitation. MATERIALS AND METHODS: In this single-arm prospective cohort study, consecutive patients undergoing elective colorectal oncological surgery were offered a 3- to 4-week multimodal prehabilitation program (supervised physical exercise training, dietary consultation, protein and vitamin supplementation, smoking cessation, and psychological support)...
February 21, 2024: Acta Oncologica
https://read.qxmd.com/read/38476802/palliative-treatment-of-leptomeningeal-carcinomatosis-from-renal-cell-carcinoma-with-local-cyberknife-radiotherapy-and-systemic-pazopanib-therapy-a-case-report
#14
Shinichiro Mizumatsu, Kenichi Wakabayashi, Yasuhiro Terashima
Leptomeningeal carcinomatosis (LMC) from renal cell carcinoma (RCC) is rare. There is no established treatment strategy for LMC, and the prognosis is extremely poor. We describe a case of LMC from RCC treated with local CyberKnife radiotherapy (CKR) and systemic therapy with pazopanib. The patient was a 63-year-old man with brain metastases from right RCC. Surgery and CKR were performed for the brain metastases, and the lesions were subsequently controlled. The patient developed isolated lesions in the pituitary stalk, right internal auditory canal, left ventricular choroid plexus (CP), left facial nerve, and medulla oblongata after the surgery and CKR for brain metastases...
February 2024: Curēus
https://read.qxmd.com/read/38474117/a-brazilian-rare-disease-center-s-experience-with-glucosylsphingosine-lyso-gb1-in-patients-with-gaucher-disease-exploring-a-novel-correlation-with-igg-levels-in-plasma-and-a-biomarker-measurement-in-csf
#15
JOURNAL ARTICLE
Matheus Vernet Machado Bressan Wilke, Gabrielle Dineck Iop, Larissa Faqueti, Layzon Antonio Lemos da Silva, Francyne Kubaski, Fabiano O Poswar, Kristiane Michelin-Tirelli, Dévora Randon, Wyllians Vendramini Borelli, Roberto Giugliani, Ida Vanessa D Schwartz
Gaucher disease (GD, OMIM 230800) is one of the most common lysosomal disorders, being caused by the deficient activity of the enzyme acid β-glucocerebrosidase (Gcase). Three clinical forms of Gaucher's disease (GD) are classified based on neurological involvement. Type 1 (GD1) is non-neuronopathic, while types 2 (GD2) and 3 (GD3) are neuronopathic forms. Gcase catalyzes the conversion of glucosylceramide (GlcCer) into ceramide and glucose. As GlcCer accumulates in lysosomal macrophages, it undergoes deacylation to become glycosylsphingosine (lyso-Gb1), which has shown to be a useful and reliable biomarker for the diagnosis and monitoring of treated and untreated patients with GD...
March 1, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38468436/inhibiting-il11ra-to-mitigate-hepatic-metastasis-in-skin-cutaneous-melanoma-comprehensive-insights-from-in-vitro-and-in-vivo-investigations
#16
JOURNAL ARTICLE
Zhen-Guo Zhang, Hong-Mei Zhu, Huai-Kang Hua
OBJECTIVE: This study aimed to investigate the role of Interleukin-11 receptor alpha (IL11RA) in skin cutaneous melanoma (SKCM) metastasis to the liver. METHODS: Human SKCM cell lines (A375, A375-MA2, SK-MEL-28, RPMI-7951) and primary dermal fibroblasts (HDFa) were utilized to assess IL11RA expression. IL11RA siRNA was transfected into RPMI-7951 and A375-MA2 cells for Wound healing and Transwell invasion assays. Il11ra knockout (KO) mice and wild-type (WT) mice were injected with B16-F10 cells into the spleen to evaluate hepatic melanoma metastasis...
March 2024: Skin Research and Technology
https://read.qxmd.com/read/38467389/thermomechanical-and-morphological-properties-of-loligo-vulgaris-squid-sucker-ring-teeth
#17
JOURNAL ARTICLE
Margot Helft, Zenghao Zhang, Cecelia Kinane, Noah Black, Abdon Pena-Francesch
Climate change is accelerating the increase of temperatures across the planet and resulting in the warming of oceans. Ocean warming threatens the survival of many aquatic species, including squids, and has introduced physiological, behavioral, and developmental changes, as well as physical changes in their biological materials composition, structure, and properties. Here, we characterize and analyze how the structure, morphology, and mechanical properties of European common squid Loligo vulgaris sucker ring teeth (SRT) are affected by temperature...
March 11, 2024: Integrative and Comparative Biology
https://read.qxmd.com/read/38466928/late-genitourinary-toxicity-in-salvage-radiotherapy-for-prostate-cancer-after-radical-prostatectomy-impact-of-daily-fraction-doses
#18
JOURNAL ARTICLE
Seiya Takano, Natsuo Tomita, Taiki Takaoka, Masanari Niwa, Akira Torii, Nozomi Kita, Dai Okazaki, Kaoru Uchiyama, Mikiko Nakanishi-Imai, Shiho Ayakawa, Masato Iida, Yusuke Tsuzuki, Shinya Otsuka, Yoshihiko Manabe, Kento Nomura, Yasutaka Ogawa, Akifumi Miyakawa, Akihiko Miyamoto, Shinya Takemoto, Takahiro Yasui, Akio Hiwatashi
OBJECTIVE: To evaluate the impact of daily fraction doses on late genitourinary (GU) toxicity after salvage radiotherapy (SRT) for prostate cancer. METHODS: This multi-institutional retrospective study included 212 patients who underwent SRT between 2008 and 2018. All patients received image-guided intensity-modulated SRT at a median dose of 67.2 Gy in 1.8-2.3 Gy/fraction. The cumulative rates of late grade ≥2 GU and gastrointestinal (GI) toxicities were compared using Gray's test, stratified by the ≤2...
March 11, 2024: British Journal of Radiology
https://read.qxmd.com/read/38465749/microneedles-a-novel-clinical-technology-for-evaluating-skin-characteristics
#19
JOURNAL ARTICLE
Seo Hyeong Kim, Ji Hye Kim, Yoon Mi Choi, Su Min Seo, Eun Young Jang, Sung Jae Lee, Suhyun Cho, Do Hyeon Jeong, Kwang Hoon Lee
BACKGROUND: Current methods for evaluating efficacy of cosmetics have limitations because they cannot accurately measure changes in the dermis. Skin sampling using microneedles allows identification of skin-type biomarkers, monitoring treatment for skin inflammatory diseases, and evaluating efficacy of anti-aging and anti-pigmentation products. MATERIALS AND METHODS: Two studies were conducted: First, 20 participants received anti-aging treatment; second, 20 participants received anti-pigmentation treatment...
March 2024: Skin Research and Technology
https://read.qxmd.com/read/38464986/mortality-after-alcohol-septal-ablation-vs-septal-myectomy-in-patients-with-obstructive-hypertrophic-cardiomyopathy
#20
JOURNAL ARTICLE
Risako Yasuda, Itsuki Osawa, Tadahiro Goto, Kohei Hasegawa, Michael A Fifer, Albree Tower-Rader, Muredach P Reilly, Mathew S Maurer, Yanling Zhao, Hiroo Takayama, Yuichi J Shimada
Background: Alcohol septal ablation (ASA) and septal myectomy (SM) are 2 options for septal reduction therapy (SRT) to treat medication-resistant symptomatic obstructive hypertrophic cardiomyopathy (HCM). Because differences in mortality rates after these different SRT methods have not been extensively investigated in real-world settings, in this study compared the 1-year mortality rates after ASA and SM using population-based database. Methods and Results: Utilizing New York Statewide Planning and Research Cooperative System (SPARCS) data from 2005 to 2016, we performed a comparative effectiveness study of ASA vs...
March 8, 2024: Circulation reports
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