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https://www.readbyqxmd.com/read/29140907/the-singapore-sling-f1-race-team-cognitive-function-and-mood-responses-during-the-singapore-grand-prix
#1
Barry V O'Neill, Kirsty M Davies, Tess E Morris
The current investigation measured cognitive performance, subjective ratings of mood and sleep in Formula 1® (F1) race team members during the 2013 Singapore Grand Prix. Two weeks prior to the Singapore Grand Prix participants (n = 16; mean age 33.5 years, range 22-48 years) underwent baseline cognitive assessments as well as a questionnaire on mood and sleep quality/duration. These assessments were repeated on the race weekend prior to practice (S1) and post qualifying (S2). A significant increase in simple reaction time (SRT), that is slowing of total response time was observed from baseline to S1 (33...
November 13, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29135878/single-sided-deafness-impact-of-cochlear-implantation-on-speech-perception-in-complex-noise-and-on-auditory-localization-accuracy
#2
Julia Döge, Uwe Baumann, Tobias Weissgerber, Tobias Rader
OBJECTIVE: To assess auditory localization accuracy and speech reception threshold (SRT) in complex noise conditions in adult patients with acquired single-sided deafness, after intervention with a cochlear implant (CI) in the deaf ear. STUDY DESIGN: Nonrandomized, open, prospective patient series. SETTING: Tertiary referral university hospital. PATIENTS: Eleven patients with late-onset single-sided deafness (SSD) and normal hearing in the unaffected ear, who received a CI...
December 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29135876/effectiveness-of-directional-microphones-in-bilateral-bimodal-cochlear-implant-users-impact-of-spatial-and-temporal-noise-characteristics
#3
Tobias Weissgerber, Tobias Rader, Uwe Baumann
OBJECTIVE: To measure speech reception thresholds (SRTs) in co-located (S0N0) and diffuse noise conditions (multi-source noise field, MSNF) and to assess the impact of beamforming algorithms in MSNF in cochlear implant (CI) users. STUDY DESIGN: Non-randomized, open, prospective study. SETTING: Tertiary referral cochlear implantation center. PATIENTS: Participants included 14 CI users (7 bimodal, 7 bilateral) and 14 normal hearing young adults...
December 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29134231/patterns-of-relapse-as-determined-by-68-ga-psma-ligand-pet-ct-after-radical-prostatectomy-importance-for-tailoring-and-individualizing-treatment
#4
Christoph Henkenberens, Thorsten Derlin, Frank M Bengel, Tobias L Ross, Hans-Jürgen Wester, Katja Hueper, Markus A Kuczyk, Hans Christiansen, Christoph A von Klot
PURPOSE: To evaluate the patterns of relapse and impact on the intended treatment when using (68)Ga-prostate-specific membrane antigen (PSMA) ligand positron emission tomography/computed tomography (PET/CT) imaging for restaging of disease in patients with biochemical relapse after radical prostatectomy (RP) before salvage radiotherapy (sRT). METHODS: In all, 39 patients with biochemical recurrence after RP who had no primary indication for adjuvant RT due to the absence of biologically unfavorable disease (e...
November 13, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29133278/imaging-for-the-detection-of-locoregional-recurrences-in-biochemical-progression-after-radical-prostatectomy-a-systematic-review
#5
REVIEW
Kristina Sandgren, Philippe Westerlinck, Joakim H Jonsson, Lennart Blomqvist, Camilla Thellenberg Karlsson, Tufve Nyholm, Piet Dirix
CONTEXT: Local and regional recurrence after radical prostatectomy (RP) can be treated using salvage radiotherapy (SRT). If the recurrence can be delineated on diagnostic imaging, this could allow for increasingly individualized SRT. OBJECTIVE: This systematic review aimed at evaluating the evidence regarding the usefulness of positron emission tomography (PET) and magnetic resonance imaging (MRI) in identifying local and regional recurrences, with the aim to further individualize the SRT treatment...
November 10, 2017: European Urology Focus
https://www.readbyqxmd.com/read/29132382/early-motor-function-after-local-treatment-of-brain-metastases-in-the-motor-cortex-region-with-stereotactic-radiotherapy-radiosurgery-or-microsurgical-resection-a-retrospective-study-of-two-consecutive-cohorts
#6
Bogdan Pintea, Brigitta Baumert, Thomas Mehari Kinfe, Konstantinos Gousias, Yaroslav Parpaley, Jan Patrick Boström
BACKGROUND: We compared the functional outcome and influential factors of two standard treatment modalities for central cerebral metastases: electrophysiological-controlled microsurgical resection (MSR) and stereotactic radiotherapy/stereotactic radiosurgery (SRT/SRS). METHODS: We performed a database search for central metastasis treatments during the period from January 2008 to September 2012 in two clinical registers: 1) register for intraoperative neuromonitoring (Department of Neurosurgery), and 2) prospective database for SRT/SRS (Department of Radiotherapy)...
November 13, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29132188/-hearing-loss-and-speech-recognition-in-the-elderly
#7
Petra von Gablenz, Inga Holube
Elderly people often complain about poor speech understanding in noisy environments. In clinical practice, speech tests under noise conditions are used to examine hearing ability. The HÖRSTAT study, conducted on a population-based random sample consisting of 1903 adults, used the Goettingen Sentence Test (GÖSA) under noise conditions along with pure-tone audiometry. Hearing impairment was defined as pure-tone average at 0.5, 1, 2 and 4 kHz (PTA-4) greater than 25 dB HL in the better ear (WHO criterion). As expected, pure-tone thresholds and speech recognition thresholds (SRT) in GÖSA worsened steadily with age...
November 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/29131974/synthetic-hospital-wastewater-treatment-by-coupling-submerged-membrane-bioreactor-and-electrochemical-advanced-oxidation-process-kinetic-study-and-toxicity-assessment
#8
Yassine Ouarda, Bhagyashree Tiwari, Antonin Azaïs, Marc-Antoine Vaudreuil, Sokhna Dieng Ndiaye, Patrick Drogui, Rajeshwhar Dayal Tyagi, Sébastien Sauvé, Mélanie Desrosiers, Gerardo Buelna, Rino Dubé
In this work, the combination of membrane bioreactor (MBR) and electro-oxidation (EO) process was studied for the treatment of a synthetic hospital wastewater fortified with four pharmaceutical pollutants namely carbamazepine (CBZ), ibuprofen (IBU), estradiol (E-E) at a concentration of 10 μg L(-1) venlafaxine (VEN) at 0.2 μg L(-1). Two treatment configurations were studied: EO process as pre-treatment and post-treatment. Wastewater treatment with MBR alone shows high removal percentages of IBU and E-E (∼90%)...
November 4, 2017: Chemosphere
https://www.readbyqxmd.com/read/29128978/on-the-influence-of-informational-content-and-key-response-effect-mapping-on-implicit-learning-and-error-monitoring-in-the-serial-reaction-time-srt-task
#9
Jascha Rüsseler, Thomas F Münte, Daniel Wiswede
The present experiment was designed to enhance our understanding of how response effects with varying amounts of useful information influence implicit sequence learning. We recorded event-related brain potentials, while participants performed a modified version of the serial reaction time task (SRTT). In this task, participants have to press one of four keys corresponding to four letters on a computer screen. Unknown to participants, in some parts of the experimental blocks, the stimuli appear in a repetitive (structured) deterministic sequence, whereas in other parts, stimuli were determined randomly...
November 11, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29128208/multi-institutional-evaluation-of-elective-nodal-irradiation-and-or-androgen-deprivation-therapy-with-postprostatectomy-salvage-radiotherapy-for-prostate-cancer
#10
Stephen J Ramey, Shree Agrawal, Matthew C Abramowitz, Drew Moghanaki, Thomas M Pisansky, Jason A Efstathiou, Jeff M Michalski, Daniel E Spratt, Jason W D Hearn, Bridget F Koontz, Stanley L Liauw, Alan Pollack, Mitchell S Anscher, Robert B Den, Kevin L Stephans, Anthony L Zietman, W Robert Lee, Andrew J Stephenson, Rahul D Tendulkar
BACKGROUND: Outcomes with postprostatectomy salvage radiation therapy (SRT) are not ideal. Little evidence exists regarding potential benefits of adding whole pelvic radiation therapy (WPRT) alone or in combination with androgen deprivation therapy (ADT). OBJECTIVE: To explore whether WPRT and/or ADT added to prostate bed radiation therapy (PBRT) improves freedom from biochemical failure (FFBF) or distant metastases (DM). DESIGN, SETTING, AND PARTICIPANTS: A database was compiled from 10 academic institutions of patients with postprostatectomy prostate-specific antigen (PSA) >0...
November 8, 2017: European Urology
https://www.readbyqxmd.com/read/29123013/-68-ga-psma-pet-ct-mapping-of-prostate-cancer-biochemical-recurrence-following-radical-prostatectomy-in-270-patients-with-psa-1-0ng-ml-impact-on-salvage-radiotherapy-planning
#11
Jérémie Calais, Johannes Czernin, Minsong Cao, Amar U Kishan, John V Hegde, Narek Shaverdian, Kiri A Sandler, Fang-I Chu, Chris R King, Michael L Steinberg, Isabel Rausher, Nina-Sophie Schmidt-Hegemann, Thorsten Poeppel, Philipp Hetkamp, Francesco Ceci, Ken Herrmann, Wolfgang P Fendler, Matthias Eiber, Nicholas G Nickols
Background: Target volume delineations for prostate cancer (PCa) salvage radiotherapy (SRT) after radical prostatectomy are usually drawn in the absence of visibly recurrent disease. Gallium-68 Prostate Specific Membrane Antigen Positron Emission Tomography/Computed Tomography ((68)Ga-PSMA-11 PET/CT) detects recurrent PCa with sensitivity superior to standard of care imaging at serum prostate specific antigen (PSA) values low enough to impact target volume delineations for routine SRT. OBJECTIVE: To i) map the recurrence pattern of PCa early biochemical recurrence (BCR) after radical prostatectomy with (68)Ga-PSMA-11 PET/CT in patients with serum PSA levels <1 ng/ml, ii) determine how often consensus clinical target volumes (CTV) based on the Radiation Therapy Oncology Group (RTOG) guidelines cover (68)Ga-PSMA-11 PET/CT-defined disease, and iii) assess the potential impact of (68)Ga-PSMA-11 PET/CT on SRT...
November 9, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29115703/moderators-of-response-to-sertraline-versus-placebo-among-recently-abstinent-cocaine-dependent-patients-a-retrospective-analysis-of-two-clinical-trials
#12
Maryam Bashiri, Michael J Mancino, Virginia A Stanick, Jeff Thostenson, Thomas R Kosten, Alison H Oliveto
BACKGROUND AND OBJECTIVES: Moderators of treatment response to serotonin reuptake inhibitor sertraline (SRT) for cocaine dependence were assessed in two randomized, double blind, placebo-controlled clinical trials. METHODS: Generalized estimating equation modeling was performed on data from cocaine-dependent volunteers randomized to receive SRT or placebo (N = 126) who completed >2-week drug-free residential portions of the 12-week trials, in which subsequent outpatient treatment (weeks 3-12) included weekly cognitive behavioral therapy and thrice-weekly supervised urine toxicology...
November 8, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/29114607/the-impact-of-different-stereotactic-radiation-therapy-regimens-for-brain-metastases-on-local-control-and-toxicity
#13
Rachel B Jimenez, Brian M Alexander, Anand Mahadevan, Andrzej Niemierko, Selvan Rajakesari, Nils D Arvold, Scott R Floyd, Kevin S Oh, Jay S Loeffler, Helen A Shih
Purpose: Stereotactic radiation therapy (SRT) enables focused, short course, high dose per fraction radiation delivery to brain tumors that are less ideal for single fraction treatment because of size, shape, or close proximity to sensitive structures. We sought to identify optimal SRT treatment regimens for maximizing local control while minimizing morbidity. Methods and materials: We performed a retrospective review of patients treated with SRT for solid brain metastases using variable dose schedules between 2001 and 2011 at 3 academic hospitals...
July 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29112532/speech-in-noise-perception-as-a-marker-of-cognitive-impairment-in-hiv-infection
#14
Yi Zhan, Abigail M Fellows, Tangkai Qi, Odile H Clavier, Sigfrid D Soli, Xiudong Shi, Jiang Gui, Yuxin Shi, Jay C Buckey
OBJECTIVES: Human immunodeficiency virus positive (HIV+) individuals report hearing difficulties, but standard audiological tests show no, or small, changes in peripheral hearing ability. The hearing complaints may reflect central nervous system (CNS) auditory processing deficits, rather than middle or inner ear problems, and may result from CNS damage due to HIV infection or treatment. If central auditory task performance and cognitive deficits in HIV+ individuals are shown to be related, then central auditory tests might serve as a "window" into CNS function in these patients...
November 4, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/29112414/squid-suckerin-biomimetic-peptides-form-amyloid-like-crystals-with-robust-mechanical-properties
#15
Shuhui Hiew, Antoni Sanchez-Ferrer, Shahrouz Amini, Feng Zhou, Jozef Adamcik, Paul A Guerette, Haibin Su, Raffaele Mezzenga, Ali Miserez
We present the self-assembly of fibers formed from a peptide sequence (A1H1) derived from suckerins proteins of squid sucker ring teeth (SRT). SRT are protein-only biopolymers with an unconventional set of physico-chemical and mechanical properties, including high elastic modulus coupled with thermoplastic behaviour. We have identified a conserved peptide building block from suckerins that possess the ability to assemble into materials with similar mechanical properties as the native SRT. A1H1 displays amphiphilic characteristics and self-assembles from the bottom-up into mm-scale fibers initiated by the addition of a polar aprotic solvent...
November 7, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29112051/a-comparison-of-the-effects-of-short-term-plyometric-and-resistance-training-on-lower-body-muscular-performance
#16
Malcolm T Whitehead, Timothy P Scheett, Michael R McGuigan, N Z Auckland, Angel V Martin
The purpose of this study was to compare effects of short-term plyometric and resistance training on lower body muscular performance. A convenience sample of thirty males aged 21.3 ± 1.8 years, height 177.3 ± 9.4 cm, mass 80.0 ± 2.6 kg, body fat 16.1 ± 1.2 % participated in this investigation. Participants were grouped and participated in progressive plyometric (PLT) or resistance training (SRT) twice per week for eight consecutive weeks or a control (CNT) group that did not participate in any training...
November 1, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29103826/impact-of-dose-intensified-salvage-radiation-therapy-on-urinary-continence-recovery-after-radical-prostatectomy-results-of-the-randomized-trial-sakk-09-10
#17
Pirus Ghadjar, Stefanie Hayoz, Jürg Bernhard, Daniel R Zwahlen, Jürgen Stein, Tobias Hölscher, Philipp Gut, Bülent Polat, Guido Hildebrandt, Arndt-Christian Müller, Paul Martin Putora, Alexandros Papachristofilou, Corinne Schär, Alan Dal Pra, Christine Biaggi Rudolf, Peter Wust, Daniel M Aebersold, George N Thalmann
INTRODUCTION: Adjuvant radiation therapy (aRT) after radical prostatectomy (RP) is associated with impaired urinary continence recovery as compared to surveillance. Less is known regarding the effect of salvage radiation therapy (sRT) dose intensification on continence outcomes. MATERIALS AND METHODS: Urinary continence recovery was investigated within a multicentre randomized trial in biochemically recurrent prostate cancer patients who received either 64 Gy (32 fractions) or 70 Gy (35 fractions) sRT...
November 3, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29101575/current-and-future-treatments-for-lysosomal-storage-disorders
#18
REVIEW
David P W Rastall, Andrea Amalfitano
Purpose of review Lysosomal storage disorders (LSDs) are a class of genetic disorders that are a testing ground for the invention of novel therapeutics including enzyme replacement therapy (ERT), substrate reduction therapy (SRT), gene therapy, and hematopoietic stem cell transplant (HSCT). This review summarizes recently approved drugs, then examines the successful clinical trials in gene therapy and HSCT. Recent findings The FDA has recently approved a second SRT by reversing an earlier FDA decision, suggesting a favorable regulatory landscape going forward...
November 4, 2017: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/29096733/bioaugmentation-with-nitrifying-granules-in-low-srt-flocculent-activated-sludge-at-low-temperature
#19
(no author information available yet)
Nitrifying granules were grown in a sidestream reactor fed municipal anaerobic digestion centrate and added in an initial slug dose and subsequent smaller daily doses to a non-nitrifying mainstream activated sludge system at 12C and 2.5-day aerobic solids retention time (SRT) to increase its nitrification capacity. Effluent NH3-N concentrations less than 1 mg/L were achieved with bioaugmentation, and nitrification was immediately lost when granules were removed after 30 days of bioaugmentation. Molecular microbial analyses indicated that nitrifying organisms remained attached to granules in the mainstream system with little loss to the flocculent sludge...
November 1, 2017: Water Environment Research: a Research Publication of the Water Environment Federation
https://www.readbyqxmd.com/read/29096316/degradation-of-triclosan-and-triclocarban-and-formation-of-transformation-products-in-activated-sludge-using-benchtop-bioreactors
#20
Dana L Armstrong, Nuria Lozano, Clifford P Rice, Mark Ramirez, Alba Torrents
Benchtop bioreactors were run aerobically with activated sludge samples collected from a large municipal wastewater treatment plant (WWTP) to understand how increased hydraulic retention time (HRT), sludge retention time (SRT), and varying treatment temperatures (21°C and 30°C) impact concentrations of the endocrine disrupting antimicrobials triclosan (TCS), triclocarban (TCC), and their transformation products. Samples from the reactors were collected periodically over a 122-196h period and the solid and liquid fraction were separately quantitated for TCS, TCC, and methyltriclosan (MeTCS) and scanned qualitatively for six other transformation products...
October 30, 2017: Environmental Research
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