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https://www.readbyqxmd.com/read/28803392/attitudes-of-individuals-with-gaucher-disease-toward-substrate-reduction-therapies
#1
Victoria F Wagner, Hope Northrup, S Shahrukh Hashmi, Joanne M Nguyen, Mary Kay Koenig, Jessica M Davis
Type 1 Gaucher disease (GD) is the most common lysosomal storage disorder. Previously, treatment for GD was limited to intravenous enzyme replacement therapies (ERTs). More recently, oral substrate reduction therapies (SRTs) were approved for treatment of GD. Although both therapies alleviate disease symptoms, attitudes toward SRTs and patient perceptions of health while using SRT have not been well established. Electronic surveys were administered to adults with GD and asked about treatment history, attitudes toward SRTs, and perception of health while using SRTs as compared to ERTs, if applicable to the participant...
August 13, 2017: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/28799923/fouling-modeling-of-the-mixed-liquor-in-mbr-by-the-individual-and-combined-models
#2
Bo Hu, Xingtao Zuo, Juan Xiong, Ruiling Bao, Jiajie He
To predict the membrane fouling phenomena in the membrane filtration operation, the individual models derived from Darcy's law and the corresponding combined models were employed to investigate the kind of models that provided better fits. The filtration of the mixed liquid from membrane bioreactors with different sludge retention time (SRT) at a constant pressure was carried out. The variation of applied pressure had significantly effect on the kind of the individual model provided better fit for the data at longer SRT and less effect for the data at shorter SRT, though it had less effect on the kind of the combined model that provided better fit...
August 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28793907/risk-adapted-dose-intensified-postoperative-radiation-therapy-in-prostate-cancer-patients-using-a-simultaneous-integrated-boost-technique-applied-with-helical-tomotherapy
#3
Marcus Beck, Peter Wust, Tomasz Barelkowski, David Kaul, Alexander-Henry Thieme, Sascha Wecker, Waldemar Wlodarczyk, Volker Budach, Pirus Ghadjar
BACKGROUND: Postoperative adjuvant radiation therapy (ART) in T3 and R1 prostate cancer as well as salvage radiation therapy (SRT) in case of postoperative biochemical failure (BF) are established treatments. Dose-intensified postoperative radiation therapy (RT) schemes have shown superior biochemical control accompanied by increased toxicity rates. In our study we evaluate a novel risk adapted dose-intensified postoperative RT scheme. METHODS: A consecutive series of prostate cancer patients receiving postoperative RT after radical prostatectomy using helical Tomotherapy between 04/2012 and 04/2015 was analyzed retrospectively...
August 10, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28782075/extracellular-enzymatic-activity-of-two-hydrolases-in-wastewater-treatment-for-biological-nutrient-removal
#4
Jorge Mario Berrio-Restrepo, Julio César Saldarriaga, Mauricio Andrés Correa, Néstor Jaime Aguirre
Due to the complex nature of the wastewater (both domestic and non-domestic) composition, biological processes are widely used to remove nutrients, such as carbon (C), nitrogen (N), and phosphorous (P), which cause instability and hence contribute to the damage of water bodies. Systems with different configurations have been developed (including anaerobic, anoxic, and aerobic conditions) for the joint removal of carbon, nitrogen, and phosphorus. The goal of this research is to evaluate the extracellular activity of β-glucosidase and phosphatase enzymes in a University of Cape Town (UCT) system fed with two synthetic wastewaters of different molecular complexity...
August 7, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28780278/season-independent-cognitive-deficits-in-seasonal-affective-disorder-and-their-relation-to-depressive-symptoms
#5
Liv Vadskjær Hjordt, Dea Siggaard Stenbæk, Brice Ozenne, Brenda Mc Mahon, Ida Hageman, Steen Gregers Hasselbalch, Gitte Moos Knudsen
Although cognitive impairments are common in depressed individuals, it is unclear which aspects of cognition are affected and whether they represent state or trait features of depression. We here exploited a naturalistic model, namely the seasonal fluctuations in depressed status in individuals with Seasonal Affective Disorder (SAD), to study depression-related cognition, longitudinally. Twenty-nine medication-free individuals diagnosed with winter-SAD and 30 demographically matched healthy controls with no seasonality symptoms completed the Letter-number Sequencing task (LNS), the Symbol Digit Modalities Test (SDMT) and the Simple Reaction Time (SRT) twice; in summer and in winter...
July 30, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28779974/impact-of-early-salvage-radiation-therapy-in-patients-with-persistently-elevated-or-rising-prostate-specific-antigen-after-radical-prostatectomy
#6
Nicola Fossati, R Jeffrey Karnes, Michele Colicchia, Stephen A Boorjian, Alberto Bossi, Thomas Seisen, Nadia Di Muzio, Cesare Cozzarini, Barbara Noris Chiorda, Claudio Fiorino, Giorgio Gandaglia, Paolo Dell'Oglio, Shahrokh F Shariat, Gregor Goldner, Steven Joniau, Antonino Battaglia, Karin Haustermans, Gert De Meerleer, Valérie Fonteyne, Piet Ost, Hendrik Van Poppel, Thomas Wiegel, Francesco Montorsi, Alberto Briganti
BACKGROUND: Salvage radiation therapy (SRT) is a recommended treatment option for biochemical recurrence after radical prostatectomy (RP). However, its effectiveness may be limited to specific categories of patients. OBJECTIVE: We aimed to identify the optimal candidates for early SRT after RP. DESIGN, SETTING, AND PARTICIPANTS: The study included 925 node-negative patients treated with SRT after RP at seven institutions. Patients received SRT for either prostate-specific antigen (PSA) rising, or PSA persistence after RP that was defined as PSA level ≥0...
August 2, 2017: European Urology
https://www.readbyqxmd.com/read/28771115/simultaneous-nitrification-and-denitrification-in-the-activated-sludge-systems-of-continuous-flow
#7
Rodrigo F Bueno, Roque P Piveli, Fábio Campos, Pedro A Sobrinho
This study has investigated the biological nitrogen removal by simultaneous nitrification and denitrification processes (SND) in a system of continuous flow activated sludge process. The investigation had four stages and evaluated the system behavior under different solid retention times (SRT), food-to-mass ratios (F/M) and dissolved oxygen (DO) concentrations. The data showed that the concentration of DO 0.5±0.2 mgO2/L did not affect the growth of heterotrophic bacteria (2.2-3.1 d-1 at 20°C) and autotrophic nitrifying bacteria (0...
August 3, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28766488/effect-of-high-strength-food-wastes-on-anaerobic-co-digestion-of-sewage-sludge
#8
(no author information available yet)
Anaerobic co-digestion has been practiced at water resource recovery facilities to increase methane production, but theimpact of many variables is still not well understood. In this study, the feasibility of co-digesting fats, oils and grease (FOG) and other high strength wastes (HSWs) with municipal sewage sludge was investigated. Four lab-scale, digesters were operated at a working volume of 9.75 L, 15 day SRT and temperature of 37 oC. Wastes including whey (cheese), juice, grease trap waste (GTW) and dissolved air flotation waste (DAF), along with municipal sewage sludge, were fed to the digesters in varying amounts...
July 6, 2017: Water Environment Research: a Research Publication of the Water Environment Federation
https://www.readbyqxmd.com/read/28752807/objective-assessment-of-listening-effort-coregistration-of-pupillometry-and-eeg
#9
Kelly Miles, Catherine McMahon, Isabelle Boisvert, Ronny Ibrahim, Peter de Lissa, Petra Graham, Björn Lyxell
Listening to speech in noise is effortful, particularly for people with hearing impairment. While it is known that effort is related to a complex interplay between bottom-up and top-down processes, the cognitive and neurophysiological mechanisms contributing to effortful listening remain unknown. Therefore, a reliable physiological measure to assess effort remains elusive. This study aimed to determine whether pupil dilation and alpha power change, two physiological measures suggested to index listening effort, assess similar processes...
January 2017: Trends in Hearing
https://www.readbyqxmd.com/read/28748774/exposure-to-parental-psychopathology-and-offspring-s-risk-of-suicide-related-thoughts-and-behaviours-a-systematic-review
#10
S M Goodday, J Shuldiner, S Bondy, A E Rhodes
AIMS: The primary objective of this systematic review was to identify and synthesise analytic studies examining the association between exposure to parental psychopathology in childhood and the nature of subsequent suicide-related thoughts (SRT) and suicide-related behaviour (SRB) (severity of ideation, planned/unplanned attempts/lethality) and to describe the direction, and magnitude of associations. The secondary objective was to determine if the associations from the primary objective differ by the type(s) and timing of parental psychopathology, sex/gender of the parent and child and is mediated by child psychiatric symptoms and family functioning...
July 27, 2017: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/28748746/long-term-urodynamic-findings-following-radical-prostatectomy-and-salvage-radiotherapy
#11
Maria Ervandian, Jens Christian Djurhuus, Morten Høyer, Charlotte Graugaard-Jensen, Michael Borre
OBJECTIVE: Lower urinary tract symptoms (LUTS) are common following radical prostatectomy (RP) or intended curative radiotherapy in prostate cancer patients. One-quarter of those treated with RP experience biochemical failure and are subsequently offered salvage radiotherapy (SRT) to the prostatic bed. The aim of this study was to elucidate long-term LUTS after surgery and SRT. MATERIALS AND METHODS: Urodynamic parameters from 16 patients treated with RP and subsequent SRT in the period 2000-2010 were evaluated with uroflowmetry, filling cystometry, pressure-flow and urethral pressure profile (UPP)...
July 27, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/28748716/late-urinary-morbidity-and-quality-of-life-after-radical-prostatectomy-and-salvage-radiotherapy-for-prostate-cancer
#12
Maria Ervandian, Morten Høyer, Stine Elleberg Petersen, Lisa Sengeløv, Steinbjørn Hansen, Mette Moe Kempel, Peter Meidahl Petersen, Michael Borre
OBJECTIVE: There is a paucity of knowledge of long-term urinary morbidity in patients treated for prostate cancer (PCa) with radical prostatectomy (RP) and salvage radiotherapy (SRT). Improved long-term survival calls for heightened awareness of late effects from radiotherapy after RP. The purpose of this study was to assess late urinary morbidity and its potential impact on quality of life (QoL) in patients treated with RP plus SRT compared with patients treated with RP alone. MATERIALS AND METHODS: Long-term morbidity and QoL were evaluated using a cross-sectional design with validated questionnaires in urinary morbidity [Danish Prostatic Symptom Score (DAN-PSS)] and QoL [European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30)]...
July 27, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/28747524/treatment-outcomes-from-68-gapsma-pet-ct-informed-salvage-radiation-treatment-in-men-with-rising-psa-following-radical-prostatectomy-prognostic-value-of-a-negative-psma-pet
#13
Louise Emmett, Pim Van Leeuwen, Rohan Nandurkar, Matthijs J Scheltema, Thomas Cusick, George Hruby, Andrew Kneebone, Thomas Eade, Gerald Fogarty, Raj Jagavkar, Quoc Nguyen, Bao Ho, Anthony M Joshua, Phillip Stricker
Introduction:(68)Ga PSMA PET CT (PSMA) is increasingly used in men with PSA failure post radical prostatectomy (RP) to triage those who will benefit from salvage radiation treatment (SRT). This study examines the value of PSMA informed SRT in improving treatment outcomes in the context of biochemical failure post RP. Methods: We analysed men with rising PSA post RP with PSA readings between 0.05 and 1.0 ng/ml, considered eligible for SRT at the time of PSMA. For each patient, clinical and pathological features as well as scan results, including site of PSMA positive disease, number of lesions, and a certainty score were documented...
July 26, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28745273/performance-and-kinetics-of-nitrification-of-low-ammonia-wastewater-at-low-temperature
#14
(no author information available yet)
The objective of this study was to investigate the effect of DO on nitrification in a sequencing batch reactor (SBR) treating low ammonia wastewater (40 mg N/L) at low temperature (14oC). During the 130 days of operation, three DO levels (5-6 mg DO/L, 2-3 mg DO/L and 0.8-1.0 mg DO/L) were tested. DO reduction resulted in lower ammonia oxidizing bacteria (AOB) and nitrite oxidizing bacteria (NOB) activity with decreasing ammonia conversion ratio (ACR) and increasing nitrite accumulation ratio (NAR). The maximum growth rates of AOB and NOB determined in this study (0...
July 25, 2017: Water Environment Research: a Research Publication of the Water Environment Federation
https://www.readbyqxmd.com/read/28745270/chromosomal-and-nuclear-alterations-in-the-root-tip-cells-of-vicia-faba-induced-by-sodium-chloride
#15
(no author information available yet)
The objective of this study was to investigate the effect of DO on nitrification in a sequencing batch reactor (SBR) treating low ammonia wastewater (40 mg N/L) at low temperature (14oC). During the 130 days of operation, three DO levels (5-6 mg DO/L, 2-3 mg DO/L and 0.8-1.0 mg DO/L) were tested. DO reduction resulted in lower ammonia oxidizing bacteria (AOB) and nitrite oxidizing bacteria (NOB) activity with decreasing ammonia conversion ratio (ACR) and increasing nitrite accumulation ratio (NAR). The maximum growth rates of AOB and NOB determined in this study (0...
July 19, 2017: Water Environment Research: a Research Publication of the Water Environment Federation
https://www.readbyqxmd.com/read/28741887/linac-based-stereotactic-radiation-therapy-for-canine-non-lymphomatous-nasal-tumours-29-cases-2013-2016
#16
T L Gieger, M W Nolan
Twenty-nine dogs were treated with linac-based stereotactic radiation therapy (SRT) for non-lymphomatous nasal tumours. Only dogs with a follow-up time >365 days were included in this retrospective analysis. No dogs had evidence of distant metastasis at diagnosis. Treatment was planned and a total of 30 Gy in 3 daily 10 Gy fractions was delivered using intensity-modulation, cone-beam CT-based image guidance and a robotic treatment couch. Clinical signs improved in all cases. Nineteen dogs had CT scans 3-4 months post-SRT and all had partial or complete tumour response...
July 25, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28734875/investigation-of-the-feasibility-of-non-invasive-optical-sensors-for-the-quantitative-assessment-of-dehydration
#17
Cobus Visser, Eduard Kieser, Kiran Dellimore, Dawie van den Heever, Johan Smith
This study explores the feasibility of prospectively assessing infant dehydration using four non-invasive, optical sensors based on the quantitative and objective measurement of various clinical markers of dehydration. The sensors were investigated to objectively and unobtrusively assess the hydration state of an infant based on the quantification of capillary refill time (CRT), skin recoil time (SRT), skin temperature profile (STP) and skin tissue hydration by means of infrared spectrometry (ISP). To evaluate the performance of the sensors a clinical study was conducted on a cohort of 10 infants (aged 6-36 months) with acute gastroenteritis...
July 19, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28724252/effect-of-operating-conditions-on-speciation-and-bioavailability-of-trace-metals-in-submerged-anaerobic-membrane-bioreactors
#18
Pham Minh Thanh, Balachandran Ketheesan, Yan Zhou, David C Stuckey
This study investigated the effect of changes in pH (7, 6.5 and 6), hydraulic retention time (HRT) (6h, 4h, and 2h), solids retention time (SRT) (100d and 25d) on the speciation of trace metals (TMs) in submerged anaerobic membrane bioreactors (SAMBRs). The results showed that the metal retention capacity of SAMBRs reduced when the pH, HRT and SRT were reduced i.e. up to 21.9%, 39.1%, and 17.1%, respectively, but it was also found that the speciation of these TMs generally shifted towards highly bioavailable fractions i...
July 8, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28718051/coronary-heart-disease-preoperative-gesture-interactive-diagnostic-system-based-on-augmented-reality
#19
Yi-Bo Zou, Yi-Min Chen, Ming-Ke Gao, Quan Liu, Si-Yu Jiang, Jia-Hui Lu, Chen Huang, Ze-Yu Li, Dian-Hua Zhang
Coronary heart disease preoperative diagnosis plays an important role in the treatment of vascular interventional surgery. Actually, most doctors are used to diagnosing the position of the vascular stenosis and then empirically estimating vascular stenosis by selective coronary angiography images instead of using mouse, keyboard and computer during preoperative diagnosis. The invasive diagnostic modality is short of intuitive and natural interaction and the results are not accurate enough. Aiming at above problems, the coronary heart disease preoperative gesture interactive diagnostic system based on Augmented Reality is proposed...
August 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28716370/a-systematic-review-and-framework-for-the-use-of-hormone-therapy-with-salvage-radiation-therapy-for-recurrent-prostate-cancer
#20
REVIEW
Daniel E Spratt, Robert T Dess, Zachary S Zumsteg, Daniel W Lin, Phuoc T Tran, Todd M Morgan, Emmanuel S Antonarakis, Paul L Nguyen, Charles J Ryan, Howard M Sandler, Matthew R Cooperberg, Edwin Posadas, Felix Y Feng
CONTEXT: Salvage radiotherapy (SRT) is a standard of care for men who recur postprostatectomy, and recent randomized trials have assessed the benefit and toxicity of adding hormone therapy (HT) to SRT with differing results. OBJECTIVE: To perform a systematic review of randomized phase III trials of the use of SRT ± HT and generate a framework for the use of HT with SRT. EVIDENCE ACQUISITION: Systematic literature searches were conducted on February 15, 2017 in three databases (MEDLINE [via PubMed], EMBASE, and ClinicalTrials...
July 14, 2017: European Urology
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