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https://www.readbyqxmd.com/read/27930704/in-vitro-antifungal-activity-of-sertraline-and-synergistic-effects-in-combination-with-antifungal-drugs-against-planktonic-forms-and-biofilms-of-clinical-trichosporon-asahii-isolates
#1
Lin Cong, Yong Liao, Suteng Yang, Rongya Yang
Trichosporon asahii (T. asahii) is the major pathogen of invasive trichosporonosis which occurred mostly in immunocompromised patients. The biofilms formation ability of T. asahii may account for resistance to antifungal drugs and results a high mortality rate. Sertraline, a commonly prescribed antidepressant, has been demonstrated to show in vitro and in vivo antifungal activities against many kinds of pathogenic fungi, especially Cryptococcus species. In the present study, the in vitro activities of sertraline alone or combined with fluconazole, voriconazole, itraconazole, caspofungin and amphotericin B against planktonic forms and biofilms of 21 clinical T...
2016: PloS One
https://www.readbyqxmd.com/read/27925576/comparison-of-oxygen-transfer-parameters-and-oxygen-demands-in-bioreactors-operated-at-low-and-high-dissolved-oxygen-levels
#2
Richard O Mines, Matthew C Callier, Benjamin J Drabek, André J Butler
The proper design of aeration systems for bioreactors is critical since it can represent up to 50% of the operational and capital cost at water reclamation facilities. Transferring the actual amount of oxygen needed to meet the oxygen demand of the wastewater requires α- and β-factors, which are used for calculating the actual oxygen transfer rate (AOTR) under process conditions based on the standard oxygen transfer rate (SOTR). The SOTR is measured in tap water at 20°C, 1 atmospheric pressure, and 0 mg L(-1) of dissolved oxygen (DO)...
December 7, 2016: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/27925207/acetate-metabolism-does-not-reflect-astrocytic-activity-contributes-directly-to-gaba-synthesis-and-is-increased-by-silent-information-regulator-1-activation
#3
Benjamin D Rowlands, Matthias Klugmann, Caroline D Rae
[(13) C]acetate is known to label metabolites preferentially in astrocytes rather than neurons and it has consequently been used as a marker for astrocytic activity. Recent discoveries suggest that control of acetate metabolism and its contributions to the synthesis of metabolites in brain is not as simple as first thought. Here, using a Guinea pig brain cortical tissue slice model metabolizing [1-(13) C]D-glucose and [1,2-(13) C]acetate, we investigated control of acetate metabolism and the degree to which it reflects astrocytic activity...
December 7, 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27915059/a-process-for-polyhydroxyalkanoate-pha-production-from-municipal-wastewater-treatment-with-biological-carbon-and-nitrogen-removal-demonstrated-at-pilot-scale
#4
Simon Bengtsson, Anton Karlsson, Tomas Alexandersson, Luca Quadri, Markus Hjort, Peter Johansson, Fernando Morgan-Sagastume, Simon Anterrieu, Monica Arcos-Hernandez, Lamija Karabegovic, Per Magnusson, Alan Werker
A process was developed for biological treatment of municipal wastewater for carbon and nitrogen removal while producing added-value polyhydroxyalkanoates (PHAs). The process comprised steps for pre-denitrification, nitrification and post-denitrification and included integrated fixed-film activated sludge (IFAS) with biofilm carrier media to support nitrification. In a pilot-scale demonstration (500-800L), wastewater treatment performance, in line with European standards, were achieved for total chemical oxygen demand (83% removal) and total nitrogen (80% removal) while producing a biomass that was able to accumulate up to 49% PHA of volatile suspended solids with acetic acid or fermented organic residues as substrates...
November 30, 2016: New Biotechnology
https://www.readbyqxmd.com/read/27910252/memory-performance-on-the-story-recall-test-and-prediction-of-cognitive-dysfunction-progression-in-mild-cognitive-impairment-and-alzheimer-s-dementia
#5
Jong-Hwan Park, Hyuntae Park, Sang Wuk Sohn, Sungjae Kim, Kyung Won Park
AIM: To determine the factors that influence diagnosis and differentiation of patients with mild cognitive impairment (MCI) and Alzheimer's dementia (AD) by comparing memory test results at baseline with those at 1-2-year follow up. METHODS: We consecutively recruited 23 healthy participants, 44 MCI patients and 27 patients with very mild AD according to the National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorder Association criteria for probable Alzheimer's disease and Petersen's clinical diagnostic criteria...
December 1, 2016: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/27902965/oxygen-transfer-dynamics-and-activated-sludge-floc-structure-under-different-sludge-retention-times-at-low-dissolved-oxygen-concentrations
#6
Haitao Fan, Xiuhong Liu, Hao Wang, Yunping Han, Lu Qi, Hongchen Wang
In activated sludge systems, the aeration process consumes the most energy. The energy cost can be dramatically reduced by decreasing the operating dissolved oxygen (DO) concentration. However, low DO may lead to incomplete nitrification and poor settling performance of activated sludge flocs (ASFs). This study investigates oxygen transfer dynamics and settling performances of activated sludge under different sludge retention times (SRTs) and DO conditions using microelectrodes and microscopic techniques. Our experimental results showed that with longer SRTs, treatment capacity and settling performances of activated sludge improved due to smaller floc size and less extracellular polymeric substances (EPS)...
November 27, 2016: Chemosphere
https://www.readbyqxmd.com/read/27881184/stereotactic-radiotherapy-for-wet-age-related-macular-degeneration-star-study-protocol-for-a-randomised-controlled-clinical-trial
#7
James E Neffendorf, Riti Desai, Yanzhong Wang, Joanna Kelly, Caroline Murphy, Barnaby C Reeves, Usha Chakravarthy, Sarah Wordsworth, Cornelius Lewis, Janet Peacock, Shahir Uddin, Joe M O'Sullivan, Timothy L Jackson
BACKGROUND: The standard of care for neovascular age-related macular degeneration (nAMD) involves ongoing intravitreal injections of anti-angiogenic drugs targeting vascular endothelial growth factor (VEGF). The most commonly used anti-VEGF drugs are ranibizumab, bevacizumab and aflibercept. The main objective of the STAR trial is to determine if stereotactic radiotherapy can reduce the number of anti-VEGF injections that patients with nAMD require. METHODS/DESIGN: STAR is a multicentre, double-masked, randomised, sham-controlled clinical trial...
November 24, 2016: Trials
https://www.readbyqxmd.com/read/27881086/lower-extremity-resistance-training-on-unstable-surfaces-improves-proxies-of-muscle-strength-power-and-balance-in-healthy-older-adults-a-randomised-control-trial
#8
Nils Eckardt
BACKGROUND: It is well documented that both balance and resistance training have the potential to mitigate intrinsic fall risk factors in older adults. However, knowledge about the effects of simultaneously executed balance and resistance training (i.e., resistance training conducted on unstable surfaces [URT]) on lower-extremity muscle strength, power and balance in older adults is insufficient. The objective of the present study was to compare the effects of machine-based stable resistance training (M-SRT) and two types of URT, i...
November 24, 2016: BMC Geriatrics
https://www.readbyqxmd.com/read/27878873/the-effects-of-spaced-retrieval-training-in-improving-hyperphagia-of-people-living-with-dementia-in-residential-settings
#9
Chia-Ning Hsu, Li-Chan Lin, Shiao-Chi Wu
AIMS AND OBJECTIVES: To investigate the effectiveness of spaced retrieval for improving hyperphagia in patients with dementia in residential care settings. BACKGROUND: Although 10-30% of patients with dementia have hyperphagia, most studies have focused on eating difficulties. Only a few studies have focused on hyperphagia. Various memory problems cause hyperphagia in patients with dementia. Spaced retrieval (SR), a cognitive technique for information learning, can be used as a training method to improve memory loss...
November 22, 2016: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/27878774/a-model-for-determination-of-operational-conditions-for-successful-shortcut-nitrification
#10
Xiaoguang Liu, Mingu Kim, George Nakhla
Accumulation of nitrite in shortcut nitrification is influenced by several factors including dissolved oxygen concentration (DO), pH, temperature, free ammonia (FA), and free nitrous acid (FNA). In this study, a model based on minimum dissolved oxygen concentration (DOmin), minimum/maximum substrate concentration (Smin and Smax), was developed. The model evaluated the influence of pH (7-9), temperature (10-35 °C), and solids retention time (SRT) (5 days-infinity) on MSC values. The evaluation was conducted either by controlling total ammonium nitrogen (TAN) or total nitrite nitrogen (TNN), concentration at 50 mg N/L while allowing the other to vary from 0 to 1000 mg N/L...
November 23, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27863963/the-dose-response-of-salvage-radiotherapy-following-radical-prostatectomy-a-systematic-review-and-meta-analysis
#11
Christopher R King
PURPOSE/OBJECTIVES: To date neither the optimal radiotherapy dose nor the existence of a dose-response has been established for salvage RT (SRT). MATERIALS/METHODS: A systematic review from 1996 to 2015 and meta-analysis was performed to identify the pathologic, clinical and treatment factors associated with relapse-free survival (RFS) after SRT (uniformly defined as a PSA>0.2ng/mL or rising above post-SRT nadir). A sigmoidal dose-response curve was objectively fitted and a non-parametric statistical test used to determine significance...
November 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27856107/a-sequence-learning-impairment-in-dyslexia-it-depends-on-the-task
#12
Lisa M Henderson, Meesha Warmington
Language acquisition is argued to be dependent upon an individuals' sensitivity to serial-order regularities in the environment (sequential learning), and impairments in reading and spelling in dyslexia have recently been attributed to a deficit in sequential learning. The present study examined the learning and consolidation of sequential knowledge in 30 adults with dyslexia and 29 typical adults matched on age and nonverbal ability using two tasks previously reported to be sensitive to a sequence learning deficit...
November 14, 2016: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/27855542/assessment-of-activated-sludge-membrane-bioreactors-and-vertical-flow-wetlands-for-upgrading-sewage-treatment-works
#13
A Besancon, K S Le Corre, G Dotro, B Jefferson
This paper demonstrates that utilising a vertical flow (VF) wetland after a conventional activated sludge (CAS) delivers equivalent or better effluent quality to a membrane bioreactor (MBR) based on a side-by-side pilot trial. A CAS, an MBR and a CAS+VF system were run in parallel for 18 months under controlled conditions. The CAS was operated under the solids retention times (SRT) of 6, 12, and 20 days, with the effluent from each pilot plant fed onto a soil aquifer treatment column to better understand their water reuse application potential...
November 18, 2016: Environmental Technology
https://www.readbyqxmd.com/read/27829034/auditory-motor-mapping-training-comparing-the-effects-of-a-novel-speech-treatment-to-a-control-treatment-for-minimally-verbal-children-with-autism
#14
Karen Chenausky, Andrea Norton, Helen Tager-Flusberg, Gottfried Schlaug
This study compared Auditory-Motor Mapping Training (AMMT), an intonation-based treatment for facilitating spoken language in minimally verbal children with autism spectrum disorder (ASD), to a matched control treatment, Speech Repetition Therapy (SRT). 23 minimally verbal children with ASD (20 male, mean age 6;5) received at least 25 sessions of AMMT. Seven (all male) were matched on age and verbal ability to seven participants (five male) who received SRT. Outcome measures were Percent Syllables Approximated, Percent Consonants Correct (of 86), and Percent Vowels Correct (of 61) produced on two sets of 15 bisyllabic stimuli...
2016: PloS One
https://www.readbyqxmd.com/read/27826659/fractionated-stereotactic-radiotherapy-for-metastatic-brain-tumors-that-recurred-after-gamma-knife-radiosurgery-results-in-acceptable-toxicity-and-favorable-local-control
#15
Akifumi Miyakawa, Yuta Shibamoto, Shinya Takemoto, Toru Serizawa, Shinya Otsuka, Tatsuo Hirai
BACKGROUND: To treat local recurrence of brain metastases after gamma knife radiosurgery (GKS), we have used fractionated stereotactic radiotherapy (SRT). The purpose of this study was to evaluate the efficacy and toxicity of SRT in these patients. METHODS: Fifty locally recurrent metastatic brain tumors in 47 patients were treated with SRT. The median prescribed dose of GKS was 20 Gy at the periphery. The median interval between the GKS (the last session in cases in which multiple GKS procedures were performed) and recurrence was 7...
November 8, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27824681/sex-differences-in-episodic-memory-in-early-midlife-impact-of-reproductive-aging
#16
Dorene M Rentz, Blair K Weiss, Emily G Jacobs, Sara Cherkerzian, Anne Klibanski, Anne Remington, Harlyn Aizley, Jill M Goldstein
OBJECTIVE: Few have characterized cognitive changes with age as a function of menopausal stage relative to men, or sex differences in components of memory in early midlife. The study aim was to investigate variation in memory function in early midlife as a function of sex, sex steroid hormones, and reproductive status. METHODS: A total of 212 men and women aged 45 to 55 were selected for this cross-sectional study from a prenatal cohort of pregnancies whose mothers were originally recruited in 1959 to 1966...
November 7, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27815546/spectrotemporal-modulation-sensitivity-as-a-predictor-of-speech-reception-performance-in-noise-with-hearing-aids
#17
Joshua G W Bernstein, Henrik Danielsson, Mathias Hällgren, Stefan Stenfelt, Jerker Rönnberg, Thomas Lunner
The audiogram predicts <30% of the variance in speech-reception thresholds (SRTs) for hearing-impaired (HI) listeners fitted with individualized frequency-dependent gain. The remaining variance could reflect suprathreshold distortion in the auditory pathways or nonauditory factors such as cognitive processing. The relationship between a measure of suprathreshold auditory function-spectrotemporal modulation (STM) sensitivity-and SRTs in noise was examined for 154 HI listeners fitted with individualized frequency-specific gain...
November 4, 2016: Trends in Hearing
https://www.readbyqxmd.com/read/27812961/new-insights-into-statistical-learning-and-chunk-learning-in-implicit-sequence-acquisition
#18
Yue Du, Jane E Clark
Implicit sequence learning is ubiquitous in our daily life. However, it is unclear whether the initial acquisition of sequences results from learning to chunk items (i.e., chunk learning) or learning the underlying statistical regularities (i.e., statistical learning). By grouping responses with or without a distinct chunk or statistical structure into segments and comparing these responses, previous studies have demonstrated both chunk and statistical learning. However, few studies have considered the response sequence as a whole and examined the temporal dependency of the entire sequence, where the temporal dependencies could disclose the internal representations of chunk and statistical learning...
November 3, 2016: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/27804006/ramadan-fasting-effects-on-postural-control-in-the-elderly-a-comparison-between-fallers-and-non-fallers
#19
Rabeb Laatar, Rym Baccouch, Rihab Borji, Hiba Kachouri, Haithem Rebai, Sonia Sahli
Our purpose was to compare the effects of Ramadan fasting on postural control in elderly fallers and non-fallers. The protocol involved twenty-four healthy old volunteer males divided into two groups: fallers (mean age = 75.43 ± 5.26 years, weight = 67.25 ± 5.30 kg and height = 1.65 ± 0.02 m) and non-fallers (mean age = 72.3 ± 6.42 years, weight = 65.5 ± 6.15 kg and height = 1.64 ± 0.03 m). Participants performed a simple reaction time test (SRT) and a postural control protocol on four different occasions: one week before Ramadan (BR), during the second (SWR) and the fourth week (FWR) of Ramadan and three weeks after Ramadan (AR)...
November 1, 2016: Journal of Religion and Health
https://www.readbyqxmd.com/read/27798955/inhibition-of-src-family-kinases-reduces-myeloid-derived-suppressor-cells-in-head-and-neck-cancer
#20
Liang Mao, Wei-Wei Deng, Guang-Tao Yu, Lin-Lin Bu, Jian-Feng Liu, Si-Rui Ma, Lei Wu, Ashok B Kulkarni, Wen-Feng Zhang, Zhi-Jun Sun
SRC family kinases (SFKs), a group of nonreceptor tyrosine kinases, modulate multiple cellular functions, such as cell proliferation, differentiation and metabolism. SFKs display aberrant activity in progressive stages of human cancers. However, the precise role of SFKs in the head and neck squamous cell carcinoma (HNSCC) signaling network is far from clear. In this study, we found that the inhibition of SFKs activity by dasatinib effectively reduced the tumor size and population of MDSCs in the HNSCC mouse model...
October 31, 2016: International Journal of Cancer. Journal International du Cancer
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