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Ye Ji Kim, Youn Gon Lee, Dong Won Lee, Jae Hui Kim
Purpose: To evaluate short-term treatment outcomes following selective retina therapy (SRT) with real-time feedback-controlled dosimetry in Korean patients with acute idiopathic central serous chorioretinopathy (CSC). Methods: Sixteen eyes (16 patients) with acute idiopathic CSC (symptom duration < 3 months) were included in this retrospective study. All patients underwent a single session of SRT with real-time feedback-controlled dosimetry. Best-corrected visual acuity (BCVA) and central foveal thickness (CFT) before and 3 months after treatment were examined and compared...
2018: Journal of Ophthalmology
Nicola Fossati, William P Parker, R Jeffrey Karnes, Michele Colicchia, Alberto Bossi, Thomas Seisen, Nadia Di Muzio, Cesare Cozzarini, Barbara Noris Chiorda, Claudio Fiorino, Giorgio Gandaglia, Detlef Bartkowiak, Thomas Wiegel, Shahrokh Shariat, Gregor Goldner, Antonino Battaglia, Steven Joniau, Karin Haustermans, Gert De Meerleer, Valérie Fonteyne, Piet Ost, Hein Van Poppel, Francesco Montorsi, Alberto Briganti, Stephen A Boorjian
Up to 50% of patients recur after salvage radiation therapy (sRT) for prostate-specific antigen (PSA) rise following radical prostatectomy (RP). Notably, the importance of lymph node dissection (LND) at the time of RP with regard to recurrence risk following sRT has not been previously determined. Therefore, we evaluated the association between nodal yield at RP and recurrence after sRT. We performed a multi-institutional review of men with a rising PSA after RP treated with sRT. Clinicopathologic variables were abstracted, and the associations between lymph node yield and biochemical (BCR) as well as clinical recurrence (CR) after sRT were assessed using multivariable Cox proportional hazards regression models...
March 12, 2018: European Urology
Long The Nguyen, Hui Chen, Crystal Mak, Amgad Zaky, Carol Pollock, Sonia Saad
Recent studies indicate that SIRT1, an important metabolic sensor and regulator of lifespan, plays a mechanistic role in maternal obesity-induced programming of metabolic disorders in the offspring. In this study we investigate whether SIRT1 activation in early childhood can mitigate metabolic disorders due to maternal and postnatal high-fat feeding in mice. Male offspring born to chow-fed (MC) or high-fat diet-fed dams (MHF) were weaned onto postnatal chow or high-fat diet and treated with SRT1720 (SRT, 25mg/kg/2days i...
March 13, 2018: American Journal of Physiology. Endocrinology and Metabolism
Samuel T Orange, Phil Marshall, Leigh A Madden, Rebecca V Vince
This study compared the effects of a 4-week supervised (SUP) and unsupervised (UNSUP) resistance training programme followed by 12 weeks of detraining (DET). Thirty-six healthy aging adults (age: 53.6 ± 3.6 years; body mass index: 28.3 ± 5.1 kg/m) were randomly allocated to a SUP group (n = 17) or an UNSUP group (n = 19). Participants completed three training sessions per week using resistance bands and body weight movements. Measures of physical performance were administered at baseline, at the end of the training programme, and after the DET period...
March 6, 2018: Journal of Strength and Conditioning Research
Rami A El Shafie, Angela Paul, Denise Bernhardt, Henrik Hauswald, Thomas Welzel, Tanja Sprave, Adriane Hommertgen, Johannes Krisam, Daniela Schmitt, Sebastian Klüter, Kai Schubert, Christina Klose, Meinhard Kieser, Jürgen Debus, Stefan Rieken
BACKGROUND: Neurosurgical resection is recommended for symptomatic brain metastases, in oligometastatic patients or for histology acquisition. Without adjuvant radiotherapy, roughly two-thirds of the patients relapse at the resection site within 24 mo, while the risk of new metastases in the untreated brain is around 50%. Adjuvant whole-brain radiotherapy (WBRT) can reduce the risk of both scenarios of recurrence significantly, although the associated neurocognitive toxicity is substantial, while stereotactic radiotherapy (SRT) improves local control at comparably low toxicity...
March 8, 2018: Neurosurgery
Fenny S Zwart, Constance Th W M Vissers, Joseph H R Maes
It is assumed that learning on the Serial Reaction Time (SRT) task is related to learning involved in social skill development affected in autism, but this assumption has hardly been investigated. We have therefore examined associations between SRT task learning and social impairment measured by the Social Responsiveness Scale in 72 autistic and non-autistic adults. Results revealed a positive correlation between deterministic sequence learning, putatively involving explicit learning, and social impairment in autistic adults but not in non-autistic adults...
March 9, 2018: Journal of Autism and Developmental Disorders
Tatiana Fountoukidou, Philippe Raisin, Daniel Kaufmann, Jörn Justiz, Raphael Sznitman, Sebastian Wolf
PURPOSE: Selective retina therapy (SRT) is a laser treatment targeting specific posterior retinal layers. It is focused on inducing damage to the retinal pigment epithelium (RPE), while sparing other retinal tissue compared to traditional photocoagulation. However, the targeted RPE layer is invisible with most imaging modalities and induced SRT lesions cannot be monitored. In this work, imaging scans acquired from an experimental setup that couples the SRT laser beam with an optical coherence tomography (OCT) beam are analyzed in order to evaluate the treatment as they occur...
March 8, 2018: International Journal of Computer Assisted Radiology and Surgery
Haidong Hu, Kewei Liao, Yuanji Shi, Lili Ding, Yan Zhang, Hong-Qiang Ren
Wastewater-derived dissolved organic nitrogen (DON) should be minimized by municipal wastewater treatment plants (MWWTPs) to reduce its potential impact on receiving waters. Solids retention time (SRT) is a key control parameter for the activated sludge (AS) process; however, knowledge of its impact on effluent DON is limited. This study investigated the effect of SRT on the bioavailability, fluorescent components, and molecular characteristics of effluent DON in the AS process. Four lab-scale AS reactors were operated in parallel at different SRTs (5, 13, 26, and 40 days) for treatment of primary treated wastewater collected from a MWWTP...
March 5, 2018: Environmental Science & Technology
Roy de Kleijn, George Kachergis, Bernhard Hommel
Sequential action makes up the bulk of human daily activity, and yet much remains unknown about how people learn such actions. In one motor learning paradigm, the serial reaction time (SRT) task, people are taught a consistent sequence of button presses by cueing them with the next target response. However, the SRT task only records keypress response times to a cued target, and thus it cannot reveal the full time-course of motion, including predictive movements. This paper describes a mouse movement trajectory SRT task in which the cursor must be moved to a cued location...
March 2, 2018: Cognitive Science
Maria Izabel Rodrigues Severiano, Bianca Simone Zeigelboim, Hélio Afonso Ghizoni Teive, Geslaine Janaína Barbosa Santos, Vinícius Ribas Fonseca
OBJECTIVE: To assess the effectiveness of balance exercises by means of virtual reality games in Parkinson's disease. METHODS: Sixteen patients were submitted to anamnesis, otorhinolaryngological and vestibular examinations, as well as the Dizziness Handicap Inventory, Berg Balance Scale, SF-36 questionnaire, and the SRT, applied before and after rehabilitation with virtual reality games. RESULTS: Final scoring for the Dizziness Handicap Inventory and Berg Balance Scale was better after rehabilitation...
February 2018: Arquivos de Neuro-psiquiatria
Ippei Nojima, Tatsunori Watanabe, Kotaro Saito, Shigeo Tanabe, Hoshinori Kanazawa
The voluntary step execution task is a popular measure for identifying fall risks among elderly individuals in the community setting because most falls have been reported to occur during movement. However, the neurophysiological functions during this movement are not entirely understood. Here, we used electromyography (EMG) to explore the relationship between EMG-EMG coherence, which reflects common oscillatory drive to motoneurons, and motor performance associated with stepping tasks: simple reaction time (SRT) and choice reaction time (CRT) tasks...
2018: Frontiers in Human Neuroscience
Linda Chen, Jacqueline Douglass, Lawrence Kleinberg, Xiaobu Ye, Ariel E Marciscano, Patrick M Forde, Julie Brahmer, Evan Lipson, William Sharfman, Hans Hammers, Jarushka Naidoo, Chetan Bettegowda, Michael Lim, Kristin J Redmond
PURPOSE: To characterize the effect of concurrent stereotactic radiosurgery-stereotactic radiation therapy (SRS-SRT) and immune checkpoint inhibitors on patient outcomes and safety in patients with brain metastases (BMs). METHODS AND MATERIALS: We retrospectively identified metastatic non-small cell lung cancer, melanoma, and renal cell carcinoma patients who had BMs treated with SRS-SRT from 2010 to 2016 without prior whole-brain radiation therapy. We included SRS-SRT patients who were treated with anti-cytotoxic T-lymphocyte-associated protein 4 (ipilimumab) and anti-programmed cell death protein 1 receptor (nivolumab, pembrolizumab)...
March 15, 2018: International Journal of Radiation Oncology, Biology, Physics
Bryce A Figdore, H David Stensel, Mari-Karoliina H Winkler
Sidestream granular activated sludge grown on anaerobic digester dewatering centrate was bioaugmented and selectively retained to enable high nitrification performance of a 2.5-day aerobic SRT non-nitrifying flocculent activated sludge system at 12 °C. Sidestream-grown granules performed enhanced biological phosphorus removal (EBPR) and short-cut nitrogen removal via nitrite. After bioaugmentation, EBPR continued in the mainstream but ammonia oxidation was eventually to nitrate. Low effluent NH3 -N concentrations from 0...
February 14, 2018: Water Research
G Biasi, M Petasecca, S Guatelli, N Hardcastle, M Carolan, V Perevertaylo, T Kron, A B Rosenfeld
PURPOSE: Flattening filter free (FFF) beams are increasingly being considered for stereotactic radiotherapy (SRT). For the first time, the performance of a monolithic silicon array detector under 6 and 10 MV FFF beams was evaluated. The dosimeter, named "Octa" and designed by the Centre for Medical Radiation Physics (CMRP), was tested also under flattened beams for comparison. METHODS: Output factors (OFs), percentage depth-dose (PDD), dose profiles (DPs) and dose per pulse (DPP) dependence were investigated...
January 2018: Physica Medica: PM
Davide Prezzi, Radhouene Neji, Christian Kelly-Morland, Hema Verma, Tim OʼBrien, Ben Challacombe, Archana Fernando, Ashish Chandra, Ralph Sinkus, Vicky Goh
OBJECTIVES: The aim of this study was to explore the feasibility of magnetic resonance elastography (MRE) for characterizing indeterminate small renal tumors (SRTs) as part of a multiparametric magnetic resonance (MR) imaging protocol. MATERIALS AND METHODS: After institutional review board approval and informed consent were obtained, 21 prospective adults (15 men; median age, 55 years; age range, 25-72 years) with SRT were enrolled. Tumors (2-5 cm Ø) were imaged using 3-directional, gradient echo MRE...
February 16, 2018: Investigative Radiology
Adriana A Zekveld, Marieke Pronk, Henrik Danielsson, Jerker Rönnberg
Purpose: The visual Text Reception Threshold (TRT) test (Zekveld et al., 2007) has been designed to assess modality-general factors relevant for speech perception in noise. In the last decade, the test has been adopted in audiology labs worldwide. The 1st aim of this study was to examine which factors best predict interindividual differences in the TRT. Second, we aimed to assess the relationships between the TRT and the speech reception thresholds (SRTs) estimated in various conditions...
February 13, 2018: Journal of Speech, Language, and Hearing Research: JSLHR
Katja Hatz, Frank Zimmermann, Dimitrios Kardamakis, Emmanouil Lazaridis, Cengiz Türksever, Jörg Binder, Alexandros Papachristofilou, Christian Prünte
BACKGROUND AND OBJECTIVE: To evaluate the effectiveness and safety of low-energy stereotactic radiotherapy (SRT) combined with anti-vascular endothelial growth factor (VEGF) treatment following a treat-and-extend regimen (TER) in wet age-related macular degeneration (AMD). PATIENTS AND METHODS: Before/after SRT, the authors compared retrospective consecutive case series of 50 patients requiring frequent anti-VEGF treatment (every 4 or 6 weeks) in wet AMD, treated with a single session of SRT and TER (same manner pre/post-SRT)...
February 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Kenichiro Kasai
Background and aims: The selective removal of tattoos and benign cutaneous pigmented lesions with laser energy evolved rapidly with the development of the nanosecond-domain Q-switched laser (ns-laser). Recently, however, a series of picosecond-domain lasers (ps-lasers) with pulsewidths less than 1 ns has become commercially available, enabling more efficient and faster removal of pigmented lesions in the field of dermatologic laser surgery. Rationale behind the ps-laser: The efficacy of the ns-laser depended on the theory of selective photothermolysis, whereby an extremely short pulse width was delivered less than the thermal relaxation time (TRT) of a target...
December 31, 2017: Laser Therapy
Aungkana Srisuwun, Nidtaya Tantiwa, Ampin Kuntiya, Arthitaya Kawee-Ai, Apisit Manassa, Charin Techapun, Phisit Seesuriyachan
This experiment aimed to decolorize Reactive Red 159 using a high potential of a consortium of Purple Non-Sulfur Bacteria (PNSB) with an application of Response Surface Methodology (RSM) via a Central Composite Design (CCD) in open system. The three factors of Hydraulic Retention Time (HRT), Sludge Retention Time (SRT) and dye concentration were applied to the design. The decolorization was operated in an Anaerobic Sequencing Batch Reactor (AnSBR) until the system reached to a pseudo-steady state for 30 cycles in each experiment...
February 9, 2018: Preparative Biochemistry & Biotechnology
Min Soo Kim, Sung Ho Park, Eun Suk Park, Jun Bum Park, Soon Chan Kwon, In Uk Lyo, Hong Bo Sim
PURPOSE: The purpose of this study was to verify changes in diffusion tensor imaging (DTI) factors in patients with brain metastases treated with stereotactic radiotherapy (SRT). We also investigated the impact of SRT on peritumoral volumes though the use of DTI. METHODS: A total of 28 patients with brain metastases who had undergone SRT between March 2014 and December 2015 were enrolled. Magnetic resonance imaging with DTI factors, such as fractional anisotropy (FA) and apparent diffusion tensor (ADC) value, was performed 1 day before the procedure and 3 months after the procedure...
February 1, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
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