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Thomas J Hoffmann, Bronya J Keats, Noriko Yoshikawa, Catherine Schaefer, Neil Risch, Lawrence R Lustig
Age-related hearing impairment (ARHI), one of the most common sensory disorders, can be mitigated, but not cured or eliminated. To identify genetic influences underlying ARHI, we conducted a genome-wide association study of ARHI in 6,527 cases and 45,882 controls among the non-Hispanic whites from the Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort. We identified two novel genome-wide significant SNPs: rs4932196 (odds ratio = 1.185, p = 4.0x10-11), 52Kb 3' of ISG20, which replicated in a meta-analysis of the other GERA race/ethnicity groups (1,025 cases, 12,388 controls, p = 0...
October 2016: PLoS Genetics
Zahra Polat, Erdoğan Bulut, Ahmet Ataş
BACKGROUND: Spoken word recognition and speech perception tests in quiet are being used as a routine in assessment of the benefit which children and adult cochlear implant users receive from their devices. Cochlear implant users generally demonstrate high level performances in these test materials as they are able to achieve high level speech perception ability in quiet situations. Although these test materials provide valuable information regarding Cochlear Implant (CI) users' performances in optimal listening conditions, they do not give realistic information regarding performances in adverse listening conditions, which is the case in the everyday environment...
September 2016: Balkan Medical Journal
Heather Kelly, Gaven Lin, Narayan Sankaran, Jing Xia, Sridhar Kalluri, Simon Carlile
OBJECTIVE: To develop, in Australian English, the first mixed-gender, multi-talker matrix sentence test. DESIGN: Speech material consisted of a 50-word base matrix whose elements can be combined to form sentences of identical syntax but unpredictable content. Ten voices (five female and five male) were recorded for editing and preliminary level equalization. Elements were presented as single-talker sentences-in-noise during two perceptual tests: an optimization phase that provided the basis for further level correction, and an evaluation phase that perceptually validated those changes...
October 19, 2016: International Journal of Audiology
Sandra Silva-Santos, Amanda Santos, Susana Vale, Jorge Mota
The aim of this study was to examine the association between motor fitness (MF) and obesity status in preschool children. The sample comprised 467 children aged 3-6 years. Preschool children body mass index was classified according to International Obesity Task Force and categorised into three levels, normal, overweight and obesity. Total physical activity was assessed by accelerometer and MF test was assessed through two MF tests 10 × 5m shuttle run test (SRT) and a 7 m jumping distance on 2 feet test (J2F)...
October 15, 2016: Journal of Sports Sciences
Nejdet Değermenci, İbrahim Cengiz, Ergun Yildiz, Alper Nuhoglu
In this study, following the pre-treatment of olive mill wastewater (OMW), its treatment in a jet loop membrane bioreactor (JLMBR) was investigated. Among the pre-treatment options, the configuration composed of physical settling, cartridge filter and ceramic membrane showed the best performance in terms of investigated parameters. For the JLMBR that was fed by pretreated OMW, up to 93 and 87% removal efficiencies were achieved for the chemical oxygen demand (COD) and total phenol, respectively, at volumetric organic load (VOL) of 17...
October 12, 2016: Journal of Environmental Management
Derya Tilki, Felix Preisser, Pierre Tennstedt, Patrick Tober, Philipp Mandel, Thorsten Schlomm, Thomas Steuber, Hartwig Huland, Schwarz Rudolf, Cordula Petersen, Markus Graefen, Sascha Ahyai
OBJECTIVE: To analyze the comparative effectiveness of no treatment or salvage radiation therapy at biochemical recurrence (NT/sRT) versus adjuvant radiation therapy (aRT) in LN positive patients after radical prostatectomy (RP). PATIENTS AND METHODS: A total of 773 patients with LN positive prostate cancer (PCa) at RP with or without additional radiation treatment from 2005 to 2013 were retrospectively analyzed. Cox regressions addressed factors influencing biochemical recurrence (BCR) and metastasis-free survival (MFS)...
October 15, 2016: BJU International
Ferenc Kemény, Kornél Németh
A central issue in sequence learning is whether learning operates on stimulus independent abstract elements, or whether participants integrate surface features of ordered stimuli, resulting in stimulus dependent learning. Using the Serial Reaction-Time Task (SRT), the current study tests whether a previously presented sequence is transferrable from one source domain to another. Contrary to previous studies with Artificial Grammar Learning, there is a mapping between pre- and post-transfer stimuli, but contrary to previous studies using SRT the mapping is not obvious...
October 13, 2016: Quarterly Journal of Experimental Psychology: QJEP
Tao Zhang, Zehua Huang, Xiaohong Chen, Mingzhi Huang, Jujun Ruan
Dimethyl phthalate (DMP) as one of the most important and extensively used Phthalic acid esters (PAEs) is known to likely cause dysfunctions of the endocrine systems, liver, and nervous systems of animals. In this paper, the degradation and behavior of DMP were investigated in a laboratory scale anaerobic/anoxic/oxic (AAO) treatment system. In addition, a degradation model including biodegradation and sorption was formulated so as to evaluate the fate of DMP in the treatment system, and a mass balance model was designed to determine kinetic parameters of the removal model...
October 8, 2016: Journal of Environmental Management
Noa Rozendorn, Michael Wolf, Arkadi Yakirevich, Yisgav Shapira, Eldar Carmel
BACKGROUND: Tympanic membrane perforation (TMP) may be caused by acute and chronic otitis media, trauma and iatrogenic reasons. The goal of myringoplasty is to achieve a dry, self-cleansing ear with intact TM while preserving hearing. Literature review of myringoplasty outcome demonstrates results with different success rates and affecting factors. OBJECTIVES: The aim of this study was to evaluate TMP closure (TMPC) rate and hearing improvement and to assess the effect of clinical and surgical parameters on residual and recurrent perforation...
November 2016: International Journal of Pediatric Otorhinolaryngology
William A Stokes, Bernard L Jones, Shilpa Bhatia, Ayman J Oweida, Daniel W Bowles, David Raben, Julie A Goddard, Jessica D McDermott, Sana D Karam
BACKGROUND: Although laryngectomy is the treatment of choice for patients with T4 larynx cancer, many patients are unable or unwilling to undergo laryngectomy and instead pursue larynx-preservation strategies combining radiotherapy (RT) and chemotherapy. Herein, the authors analyzed the National Cancer Data Base to evaluate overall survival (OS) between patients treated with surgical and organ-preserving modalities. METHODS: The National Cancer Data Base was queried for patients diagnosed from 2004 through 2012 with T4M0 laryngeal cancer who underwent either laryngectomy (surgery) with adjuvant RT (SRT), chemotherapy starting concurrently within 7 days of RT (CCRT), or multiagent induction chemotherapy starting 43 to 98 days before RT (ICRT)...
October 11, 2016: Cancer
Preeti Patil-Chhablani, Krishnapriya Kothamasu, Ramesh Kekunnaya, Virender Sachdeva, Vivek Warkad
PURPOSE: To evaluate the surgical outcome of augmented superior rectus transposition (SRT) and medial rectus recession (MRc) in patients with abducens nerve palsy. METHODS: The medical records of consecutive patients with abducens nerve palsy who underwent unilateral or bilateral simultaneous SRT with MRc from January 2012 to December 2014. Patients with previous strabismus surgery or botulinum toxin injection were excluded. Primary outcome measures were esotropia in primary position and abduction deficit...
October 7, 2016: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
Chelsea Blankenship, Fawen Zhang, Robert Keith
BACKGROUND: Although most cochlear implant (CI) users achieve improvements in speech perception, there is still a wide variability in speech perception outcomes. There is a growing body of literature that supports the relationship between individual differences in temporal processing and speech perception performance in CI users. Previous psychophysical studies have emphasized the importance of temporal acuity for overall speech perception performance. Measurement of gap detection thresholds (GDTs) is the most common measure currently used to assess temporal resolution...
October 2016: Journal of the American Academy of Audiology
Amie L Haas, Jennifer M Barthel, Stephanie Taylor
Research has demonstrated a link between alcohol use and multiple forms of risky sexual behavior, particularly among college-age individuals. Studies have also linked heavy alcohol use to other problems, such as impaired consciousness resulting from an alcohol-induced blackout, which may impact sexual decision making. However, research has rarely examined sexual risk taking (SRT) in relation to blackouts, nor has it examined this construct during the precollege transition (i.e., the interval of time between high school graduation and college matriculation)...
October 7, 2016: Journal of Sex Research
Naohito Beppu, Fumihiko Kimura, Tsukasa Aihara, Hiroshi Doi, Naohiro Tomita, Hidenori Yanagi, Naoki Yamanaka
BACKGROUND: Short-course radiotherapy with delayed surgery (SRT-delay) is still under clinical investigation for its efficacy in treating low rectal cancer (≤5 cm from the anal verge). This study was designed to assess the pattern of local recurrence and oncologic outcomes in T3 low rectal cancer treated with SRT-delay. METHODS: This study enrolled T3 low rectal cancer patients without distant metastasis between 2003 and 2015. All patients received total mesorectal excision following SRT-delay (25 Gy/10 fractions/5 days + S-1 radiosensitizer with a 4-week delay of surgery)...
October 3, 2016: Annals of Surgical Oncology
Raphael Koning, Jan Wouters
Speech perception by cochlear implant (CI) users can be very good in quiet but their speech intelligibility (SI) performance decreases in noisy environments. Because recent studies have shown that transient parts of the speech envelope are most important for SI in normal-hearing (NH) listeners, the enhanced envelope (EE) strategy was developed to emphasize onset cues of the speech envelope in the CI signal processing chain. The influence of enhancement of the onsets of the speech envelope on SI was investigated with CI users for speech in stationary speech-shaped noise (SSN) and with an interfering talker...
September 30, 2016: Hearing Research
Shu Hui Hiew, Paul A Guerette, Ondrej J Zvarec, Margaret Phillips, Feng Zhou, Haibin Su, Konstantin Pervushin, Brendan P Orner, Ali Miserez
: The hard sucker ring teeth (SRT) from decapodiforme cephalopods, which are located inside the sucker cups lining the arms and tentacles of these species, have recently emerged as a unique model structure for biomimetic structural biopolymers. SRT are entirely composed of modular, block co-polymer-like proteins that self-assemble into a large supramolecular network. In order to unveil the molecular principles behind SRT's self-assembly and robustness, we describe a combinatorial screening assay that maps the molecular-scale interactions between the most abundant modular peptide blocks of suckerin proteins...
September 29, 2016: Acta Biomaterialia
E Meyer, D Pasquier, G Bernadou, G Calais, C Carrie, D Stefan, C Theodore, L Albiges, A Bossi, P Maroun, R De Crevoisier, C Hennequin, J L Lagrange, F Lesaunier, J M Grellard, B Clarisse, J L Habrand, A E Dugue, F Joly
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
V Kudithipudi, E E Day, N V Thai, A V Kirichenko
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Emanuele Zaffuto, Giorgio Gandaglia, Nicola Fossati, Paolo Dell'Oglio, Marco Moschini, Vito Cucchiara, Nazareno Suardi, Vincenzo Mirone, Marco Bandini, Shahrokh F Shariat, Pierre I Karakiewicz, Francesco Montorsi, Alberto Briganti
PURPOSE: The role of the time between radical prostatectomy (RP) and radiation therapy (RT) on postoperative functional outcomes is still unclear in surgically-managed prostate cancer (PCa) patients. We hypothesized that a shorter time interval between RP and RT might be associated with worse functional recovery rates after RP. MATERIALS AND METHODS: We retrospectively evaluated 2,190 patients treated with RP. Patients were stratified according to RT schedule (adjuvant RT, salvage RT, no RT)...
September 23, 2016: Journal of Urology
T Rader, H Fastl, U Baumann
BACKGROUND: After implantation of cochlear implants with hearing preservation for combined electronic acoustic stimulation (EAS), the residual acoustic hearing ability relays fundamental speech frequency information in the low frequency range. With the help of acoustic simulation of EAS hearing perception the impact of frequency and level fine structure of speech signals can be systematically examined. OBJECTIVE: The aim of this study was to measure the speech reception threshold (SRT) under various noise conditions with acoustic EAS simulation by variation of the frequency and level information of the fundamental frequency f0 of speech...
September 26, 2016: HNO
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