keyword
MENU ▼
Read by QxMD icon Read
search

Research ethics

keyword
https://www.readbyqxmd.com/read/29150470/platelet-rich-plasma-in-achilles-tendon-healing-2-path-2-trial-protocol-for-a-multicentre-participant-and-assessor-blinded-parallel-group-randomised-clinical-trial-comparing-platelet-rich-plasma-prp-injection-versus-placebo-injection-for-achilles-tendon-rupture
#1
Joseph Alsousou, David J Keene, Philippa A Hulley, Paul Harrison, Susan Wagland, Christopher Byrne, Michael Maia Schlüssel, Susan J Dutton, Sarah E Lamb, Keith Willett
BACKGROUND: Achilles tendon injuries give rise to substantial long-lasting morbidity and pose considerable challenges for clinicians and patients during the lengthy healing period. Current treatment strategies struggle to curb the burden of this injury on health systems and society due to lengthy rehabilitation, work absence and reinjury risk. Platelet-rich plasma (PRP) is an autologous preparation that has been shown to improve the mechanobiological properties of tendons in laboratory and animal studies...
November 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29150467/interventions-to-improve-adherence-to-reporting-guidelines-in-health-research-a-scoping-review-protocol
#2
David Blanco, Jamie J Kirkham, Douglas G Altman, David Moher, Isabelle Boutron, Erik Cobo
INTRODUCTION: There is evidence that the use of some reporting guidelines, such as the Consolidated Standards for Reporting Trials, is associated with improved completeness of reporting in health research. However, the current levels of adherence to reporting guidelines are suboptimal. Over the last few years, several actions aiming to improve compliance with reporting guidelines have been taken and proposed. We will conduct a scoping review of interventions to improve adherence to reporting guidelines in health research that have been evaluated or suggested, in order to inform future interventions...
November 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29149587/%C3%A2-and-the-wisdom-to-know-the-difference-scholarly-success-from-a-wisdom-perspective
#3
Judith Glück
What makes a researcher wise? At least for the field of psychology, I argue that the two main characteristics of scholarly wisdom are a desire to understand, rather than to be right, and an orientation toward ethical values. These characteristics do not necessarily produce the highest levels of academic success. Because wisdom is partly context dependent, the actual wisdom of our scientific output could be increased by making some changes to our publication and evaluation culture-changes that might benefit our field and even the world around us...
November 2017: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/29149267/taiwan-biobank-making-cross-database-convergence-possible-in-the-big-data-era
#4
Jui-Chu Lin, Chien-Te Fan, Chia-Cheng Liao, Yao-Sheng Chen
The Taiwan Biobank (TWB) is a biomedical research database of biopsy data from 200,000 participants. Access to this database has been granted to research communities taking part in the development of precision medicines; however, this has raised issues surrounding TWB's access to electronic medical records (EMR). The Personal Data Protection Act of Taiwan restricts access to EMR for purposes not covered by patients' original consent. This commentary explores possible legal solutions to help ensure that the access TWB has to EMR abides with legal obligations, and with governance frameworks associated with ethical, legal and social implications...
November 15, 2017: GigaScience
https://www.readbyqxmd.com/read/29149146/dexamethasone-and-dexmedetomidine-as-an-adjuvant-to-intraarticular-bupivacaine-for-postoperative-pain-relief-in-knee-arthroscopic-surgery-a-randomized-trial
#5
Seham M Moeen, Islam K Ramadan, Hesham A Elkady
BACKGROUND: Knee arthroscopy causes minimal trauma, however, good analgesia is required for early rehabilitation and return to normal life in the patients. OBJECTIVE: We aimed to compare the analgesic effects of intraarticular dexamethasone and dexmedetomidine added to bupivacaine with those of bupivacaine alone. STUDY DESIGN: This study uses a double-blind, randomized, controlled design with allocation concealment in a 3-armed parallel group format among patients undergoing arthroscopic meniscal surgery...
November 2017: Pain Physician
https://www.readbyqxmd.com/read/29148963/clinical-stroke-research-in-resource-limited-settings-tips-and-hints
#6
Jeyaraj D Pandian, Hueiming Liu, Dorcas Bc Gandhi, Richard I Lindley
Background Most stroke research is conducted in high income countries, yet most stroke occurs in low- and middle-income countries. There is an urgent need to build stroke research capacity in low- and middle-income countries. Aims To review the global health literature on how to improve research capacity in low- and middle-income countries, provide additional data from the recently completed ATTEND Trial and provide examples from our own experience. Summary of review The main themes from our literature review were: manpower and workload, research training, research question and methodology and research funding...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/29148954/our-life-depends-on-this-drug-competence-inequity-and-voluntary-consent-in-clinical-trials-on-supervised-injectable-opioid-assisted-treatment
#7
Daniel Steel, Kirsten Marchand, Eugenia Oviedo-Joekes
Supervised injectable opioid assisted treament (siOAT) prescribes injectable opioids to individuals for whom other forms of addiction treatment have been ineffective. In this article, we examine arguments that opioid-dependent people should be assumed incompetent to voluntarily consent to clinical research on siOAT unless proven otherwise. We agree that concerns about competence and voluntary consent deserve careful attention in this context. But we oppose framing the issue solely as a matter of the competence of opioid-dependent people and emphasize that it should be considered in the context of inequities in access to siOAT as a medical treatment...
December 2017: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/29148951/reframing-consent-for-clinical-research-a-function-based-approach
#8
Neal W Dickert, Nir Eyal, Sara F Goldkind, Christine Grady, Steven Joffe, Bernard Lo, Franklin G Miller, Rebecca D Pentz, Robert Silbergleit, Kevin P Weinfurt, David Wendler, Scott Y H Kim
Although informed consent is important in clinical research, questions persist regarding when it is necessary, what it requires, and how it should be obtained. The standard view in research ethics is that the function of informed consent is to respect individual autonomy. However, consent processes are multidimensional and serve other ethical functions as well. These functions deserve particular attention when barriers to consent exist. We argue that consent serves seven ethically important and conceptually distinct functions...
December 2017: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/29146711/ethics-health-policy-and-zika-from-emergency-to-global-epidemic
#9
Euzebiusz Jamrozik, Michael J Selgelid
Zika virus was recognised in 2016 as an important vector-borne cause of congenital malformations and Guillain-Barré syndrome, during a major epidemic in Latin America, centred in Northeastern Brazil. The WHO and Pan American Health Organisation (PAHO), with partner agencies, initiated a coordinated global response including public health intervention and urgent scientific research, as well as ethical analysis as a vital element of policy design. In this paper, we summarise the major ethical issues raised during the Zika epidemic, highlighting the PAHO ethics guidance and the role of ethics in emergency responses, before turning to ethical issues that are yet to be resolved...
November 16, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/29146661/what-is-the-relationship-between-physical-activity-and-cardiovascular-risk-factors-in-stroke-survivors-post-completion-of-rehabilitation-protocol-for-a-longitudinal-study
#10
Natalie A Fini, Julie Bernhardt, Anne E Holland
INTRODUCTION: Physical activity (PA) can modify cardiovascular and other health risks in people with stroke, but we know little about long-term PA in this group. This study aims to describe PA levels and investigate relationships between PA, cardiovascular risk factors, mobility and participant characteristics (eg, age, mood and fatigue) in the 2 years following rehabilitation discharge after first stroke. METHODS AND ANALYSIS: This is a longitudinal observational study with follow-up at 6, 12 and 24 months after rehabilitation discharge...
November 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29146660/changing-physical-activity-behaviour-for-people-with-multiple-sclerosis-protocol-of-a-randomised-controlled-feasibility-trial-istep-ms
#11
Jennifer M Ryan, Jennifer Fortune, Andrea Stennett, Cherry Kilbride, Nana Anokye, Christina Victor, Wendy Hendrie, Mohamed Abdul, Lorraine DeSouza, Grace Lavelle, Debbie Brewin, Lee David, Meriel Norris
INTRODUCTION: Although physical activity may reduce disease burden, fatigue and disability, and improve quality of life among people with multiple sclerosis (MS), many people with MS are physically inactive and spend significant time in sedentary behaviour. Behaviour change interventions may assist people with MS to increase physical activity and reduce sedentary behaviour. However, few studies have investigated their effectiveness using objective measures of physical activity, particularly in the long term...
November 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29146655/qualitative-evaluation-of-a-deferred-consent-process-in-paediatric-emergency-research-a-predict-study
#12
Jeremy Furyk, Kristin McBain-Rigg, Kerrianne Watt, Theophilus I Emeto, Richard C Franklin, Donna Franklin, Andreas Schibler, Stuart R Dalziel, Franz E Babl, Catherine Wilson, Natalie Phillips, Robin Ray
BACKGROUND: A challenge of conducting research in critically ill children is that the therapeutic window for the intervention may be too short to seek informed consent prior to enrolment. In specific circumstances, most international ethical guidelines allow for children to be enrolled in research with informed consent obtained later, termed deferred consent (DC) or retrospective consent. There is a paucity of data on the attitudes of parents to this method of enrolment in paediatric emergency research...
November 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29146651/prevalence-of-pregnancy-related-pelvic-girdle-pain-and-associated-factors-in-australia-a-cross-sectional-study-protocol
#13
Dragana Ceprnja, Lucinda Chipchase, Amitabh Gupta
INTRODUCTION: Pregnancy-related pelvic girdle pain (PPGP) is a common musculoskeletal disorder. Women with PPGP report difficulty performing everyday functional activities, such as standing and walking. However, the magnitude of the problem remains unknown in Australia. It is important to determine how many women are affected by this condition and the factors associated with PPGP as this will direct healthcare services to being able to better manage women during pregnancy. Thus, this study aims to determine the prevalence of PPGP and associated factors in a Western Sydney population...
November 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29146650/benefits-and-risks-of-iron-interventions-in-children-brisc-protocol-for-a-three-arm-parallel-group-randomised-controlled-field-trial-in-bangladesh
#14
Mohammed Imrul Hasan, Sheikh Jamal Hossain, Sabine Braat, Michael John Dibley, Jane Fisher, Sally Grantham-McGregor, Fahmida Tofail, Julie A Simpson, Shams Ei Arifeen, Jena Hamadani, Beverley-Ann Biggs, Sant-Rayn Pasricha
INTRODUCTION: Anaemia is a major global health problem affecting about 43% of preschool children globally and 60% of 6-24-month-old children in rural Bangladesh, half of which is attributed to iron deficiency (ID). Although WHO recommends universal supplementation with iron or home fortification with iron-containing multiple micronutrient powders (MMPs) to children under 2 years, evidence for benefits of these interventions on childhood development (a key rationale for these interventions) and harms (especially infection) remains limited...
November 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29145766/environmental-samples-make-soiled-bedding-sentinels-dispensable-for-hygienic-monitoring-of-ivc-reared-mouse-colonies
#15
Manuel Miller, Markus Brielmeier
Accurate knowledge of the health status of experimental animals is pivotal to high scientific and ethical standards in biomedical research. Individually ventilated cages (IVCs) are becoming the predominant system for housing laboratory mice, as they prevent cage-to-cage infections. However, this feature constitutes a major drawback for hygienic monitoring of mouse colonies, as traditional screening programs build on reliable transmission of infectious agents from experimental animals to sentinel mice commonly tested as representatives for the mouse colonies...
January 1, 2017: Laboratory Animals
https://www.readbyqxmd.com/read/29143655/consent-ethics-and-genetic-biobanks-the-case-of-the-athlome-project
#16
REVIEW
Rachel Thompson, Michael J McNamee
This article provides a critical overview of the ethics and governance of genetic biobank research, using the Athlome Consortium as a large scale instance of collaborative sports genetic biobanking. We present a traditional model of written informed consent for the acquisition, storage, sharing and analysis of genetic data and articulate the challenges to it from new research practices such as genetic biobanking. We then articulate six possible alternative consent models: verbal consent, blanket consent, broad consent, meta consent, dynamic consent and waived consent...
November 14, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29143183/micrornas-important-regulators-of-induced-pluripotent-stem-cell-generation-and-differentiation
#17
REVIEW
Zhao-Lin Zeng, Xiao-Long Lin, Li-Lan Tan, Ya-Mi Liu, Kai Qu, Zuo Wang
Induced pluripotent stem (iPS) cells can differentiate into nearly all types of cells. In contrast to embryonic stem cells, iPS cells are not subject to immune rejection because they are derived from a patient's own cells without ethical concerns. These cells can be used in regenerative medical techniques, stem cell therapy, disease modelling and drug discovery investigations. However, this application faces many challenges, such as low efficiency, slow generation time, partially reprogrammed colonies and tumourigenicity...
November 15, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/29141679/intramuscular-oxytocin-versus-intravenous-oxytocin-to-prevent-postpartum-haemorrhage-at-vaginal-delivery-labor-trial-study-protocol-for-a-randomised-controlled-trial
#18
Nita Adnan, Fiona Boland, Deirdre J Murphy
BACKGROUND: Primary postpartum haemorrhage (PPH) is one of the leading causes of maternal morbidity and mortality worldwide. The most common cause of primary PPH is uterine atony. Atonic PPH rates are increasing in developed countries despite routine active management of the third stage of labour. In less-developed countries, primary PPH remains the leading cause of maternal death. Although the value of routine oxytocics in the third stage of labour has been well established, there is inconsistent practice in the choice of agent and route of administration...
November 15, 2017: Trials
https://www.readbyqxmd.com/read/29141642/doing-implementation-research-on-health-governance-a-frontline-researcher-s-reflexive-account-of-field-level-challenges-and-their-management
#19
Gupteswar Patel, Surekha Garimella, Kerry Scott, Shinjini Mondal, Asha George, Kabir Sheikh
BACKGROUND: Implementation Research (IR) in and around health systems comes with unique challenges for researchers including implementation, multi-layer governance, and ethical issues. Partnerships between researchers, implementers, policy makers and community members are central to IR and come with additional challenges. In this paper, we elaborate on the challenges faced by frontline field researchers, drawing from experience with an IR study on Village Health Sanitation and Nutrition Committees (VHSNCs)...
November 15, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/29141610/social-relations-and-healthcare-utilisation-among-middle-aged-and-older-people-study-protocol-for-an-implementation-and-register-based-study-in-denmark
#20
Anne Sophie Bech Mikkelsen, Rikke Lund, Maria Kristiansen
BACKGROUND: While previous research establishes an association between social relations, health and use of healthcare services among older people, how to implement this knowledge in real-life settings has received much less attention. This study will explore the relationship between social relations, health and use of healthcare services in a Danish mid-life population sample. In addition, the study will explore individual and contextual factors affecting the implementation of a group-based life story intervention aimed at establishing and strengthening social relations among older people at nursing homes in Denmark...
November 15, 2017: BMC Health Services Research
keyword
keyword
20914
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"