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https://www.readbyqxmd.com/read/28922695/strategies-for-detecting-colon-cancer-in-patients-with-inflammatory-bowel-disease
#1
REVIEW
William A Bye, Tran M Nguyen, Claire E Parker, Vipul Jairath, James E East
BACKGROUND: Patients with longstanding ulcerative colitis and colonic Crohn's disease have an increased risk of colorectal cancer (CRC) compared with the general population. This review assessed the evidence that endoscopic surveillance may prolong life by allowing earlier detection of CRC or its pre-cursor lesion, dysplasia, in patients with inflammatory bowel disease (IBD). OBJECTIVES: To assess the effectiveness of cancer surveillance programs for diagnosis of IBD-associated colorectal cancer and in reducing the mortality rate from colorectal cancer in patients with IBD...
September 18, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28922617/training-the-next-generation-of-biobankers-a-two-year-master-s-course-in-the-management-of-biobanks
#2
Emmanuelle Gormally, Isabelle Hardy, Elodie Caboux, Jeanne-Hélène di Donato, Pierre Hainaut, Paul Hofman
The growing complexity of biobanking requires dedicated professional staff who are trained in multiple aspects of the biobanking process, including technical, managerial, regulatory, and ethical aspects, and who have a good understanding of the challenges of biospecimen research, but also of the challenges related to the sustainability of future biobanks. Up to the present, biobanking staff have been trained in an ad-hoc manner, usually through specific short duration courses, for example, summer schools. In this article, we describe the development/establishment of a systematic 2-year training program at the Master level intended for students with a background in life sciences and providing them with a professional qualification as a "Biobank Manager...
September 18, 2017: Biopreservation and Biobanking
https://www.readbyqxmd.com/read/28922278/defining-the-critical-elements-for-the-most-common-procedures-in-spine-surgery-a-consensus-of-orthopaedic-and-neurosurgical-surgeons
#3
Joseph L Laratta, Samuel Cohen-Tanugi, Jamal N Shillingford, Joseph M Lombardi, Lawrence G Lenke, K Daniel Riew, Ronald A Lehman, Steven C Ludwig
STUDY DESIGN: Survey. OBJECTIVE: To define the critical elements of common spine surgeries. SUMMARY OF BACKGROUND DATA: Despite significant relevance to the field of spine surgery, the term "critical element" of surgery has not been clearly defined. Every surgical procedure involves numerous steps, each with its own potential for complications and harm to the patient. Despite its crucial role in surgical training, billing, and the ethicality of concurrent surgery, the term "critical element" of surgery has not been defined...
September 15, 2017: Spine
https://www.readbyqxmd.com/read/28921810/bones-morphogenic-protein-4-and-retinoic-acid-combined-treatment-comparative-analysis-for-in-vitro-differentiation-potential-of-murine-mesenchymal-stem-cells-derived-from-bone-marrow-and-adipose-tissue-into-germ-cells
#4
Maryam H Shirzeily, Neda Khanlarkhani, Fardin Amidi, Farshad H Shirzeily, Fereydoon S Aval, Aligholi Sobhani
Nowadays, infertility is no longer considered as an unsolvable disorder due to progresses in germ cells derived from stem lineage with diverse origins. Technical and ethical challenges push researchers to investigate various tissue sources to approach more efficient gametes. The purpose of the current study is to investigate the efficacy of a combined medium, retinoic acid (RA) together with Bone Morphogenic Protein-4 (BMP4), on differentiation of Bone Marrow Mesenchymal Stem Cells (BMMSCs) and adipose-derived mesenchymal stem cells (ADMSCs) into germ cells...
September 18, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/28921637/to-serve-or-not-to-serve-ethical-and-policy-implications
#5
Leonard A Jason
The Institute of Medicine (IOM) is one of the nation's more influential health-related non-profit organizations. It plays a large role in shaping health policy by commissioning panels to develop "white papers" describing research and recommendations on a variety of health topics. These white paper publications are often used to help make policy decisions at the legislative and executive levels. Such a prominent institution might seem like a natural ally for policy-related collaborative efforts. As community psychologists, we strongly endorse efforts to positively influence public policy at the national level...
September 18, 2017: American Journal of Community Psychology
https://www.readbyqxmd.com/read/28921621/-but-we-want-to-work-the-movement-of-child-workers-in-peru-and-the-actions-for-reducing-child-labor
#6
Isidro Maya Jariego
The program Edúcame Primero (Educate Me First) is an evidence-based practice for eradicating child labor that has been applied with positive results in Colombia, Peru, and several Central American countries. In this article, we describe the difficulties of implementing the program in two poor areas of Lima (Peru) between 2014 and 2016. Specifically, we discuss three ethical challenges faced during the implementation of the program: (a) the existence of a movement of working children that defends the right of children to work; (b) the polarization of some community-based associations and government institutions on how to deal with the problems of working children; and (c) the use of network indicators in the evaluation of the community's level of cohesion...
September 18, 2017: American Journal of Community Psychology
https://www.readbyqxmd.com/read/28921599/the-stories-we-tell-introduction-to-the-special-issue-on-ethical-challenges-in-community-psychology-research-and-practice
#7
Rebecca Campbell, Michael Morris
This Special Issue examines ethical challenges in community psychology research and practice. The literature on ethics in community psychology has remained largely abstract and aspirational, with few concrete examples and case studies, so the goal of this Special Issue was to expand our written discourse about ethical dilemmas in our field. In these articles, researchers and practitioners share stories of specific ethical challenges they faced and how they sought to resolve them. These first-person narratives examine how ethical challenges come about, how community psychology values inform ethical decision making, and how lessons learned from these experiences can inform an ethical framework for community psychology...
September 18, 2017: American Journal of Community Psychology
https://www.readbyqxmd.com/read/28921557/accountability-collaboration-and-social-change-ethical-tensions-in-an-action-research-project-to-address-untested-sexual-assault-kits-saks
#8
Rebecca Campbell, Giannina Fehler-Cabral
We conducted a collaborative action research project with stakeholders in Detroit, Michigan, to develop long-term policy strategies to resolve ~11,000 untested rape kits that were discovered in a police storage facility in August 2009. In our research, we uncovered overwhelming evidence of victim-blaming behaviors and fundamental disrespect of rape survivors by the police, which directly contributed to their decisions not to submit kits for forensic testing. We had an ethical responsibility to report these negative findings accurately and completely, and in doing so, we were concerned that police stakeholders might disengage from the action research project and hamper our other ethical responsibilities to promote general and public welfare...
September 18, 2017: American Journal of Community Psychology
https://www.readbyqxmd.com/read/28921556/dating-and-sexual-violence-research-in-the-schools-balancing-protection-of-confidentiality-with-supporting-the-welfare-of-survivors
#9
Jill D Sharkey, Lauren A Reed, Erika D Felix
Rigorous research and program evaluation are needed to understand the experience of dating and sexual violence among youth and the impact of prevention and intervention efforts. Our dilemma in doing this work occurred when youth disclosed dating and sexual violence on a research survey. What responsibility do researchers have to protect survivors' confidentiality as a research participant versus taking steps to ensure the student has the opportunity to access help? In our evaluation of a pilot dating violence prevention program, our protocols employed widely used procedures for providing resources to participants upon their completion of the survey and de-identifying survey data...
September 18, 2017: American Journal of Community Psychology
https://www.readbyqxmd.com/read/28921376/legal-issues-in-governing-genetic-biobanks-the-italian-framework-as-a-case-study-for-the-implications-for-citizen-s-health-through-public-private-initiatives
#10
Cinzia Piciocchi, Rossana Ducato, Lucia Martinelli, Silvia Perra, Marta Tomasi, Carla Zuddas, Deborah Mascalzoni
This paper outlines some of the challenges faced by regulation of genetic biobanking, using case studies coming from the Italian legal system. The governance of genetic resources in the context of genetic biobanks in Italy is discussed, as an example of the stratification of different inputs and rules: EU law, national law, orders made by authorities and soft law, which need to be integrated with ethical principles, technological strategies and solutions. After providing an overview of the Italian legal regulation of genetic data processing, it considers the fate of genetic material and IP rights in the event of a biobank's insolvency...
September 18, 2017: Journal of Community Genetics
https://www.readbyqxmd.com/read/28920015/working-with-bacteria-and-putting-bacteria-to-work-the-biopolitics-of-synthetic-biology-for-energy-in-the-united-kingdom
#11
Carmen McLeod, Brigitte Nerlich, Alison Mohr
The UK government has made significant investment into so called 'fourth-generation' biofuel technologies. These biofuels are based on engineering the metabolic pathways of bacteria in order to create products compatible with existing infrastructure. Bacteria play an important role in what is promoted as a potentially new biological industrial revolution, which could address some of the negative environmental legacies of the last. This article presents results from ethnographic research with synthetic biologists who are challenged with balancing the curiosity-driven and intrinsically fulfilling scientific task of working with bacteria, alongside the policy-driven task of putting bacteria to work for extrinsic economic gains...
August 2017: Energy Research & Social Science
https://www.readbyqxmd.com/read/28919655/the-ethics-of-germline-gene-editing
#12
Christopher Gyngell, Thomas Douglas, Julian Savulescu
Germline Gene Editing (GGE) has enormous potential both as a research tool and a therapeutic intervention. While other types of gene editing are relatively uncontroversial, GGE has been strongly resisted. In this article, we analyse the ethical arguments for and against pursuing GGE by allowing and funding its development. We argue there is a strong case for pursuing GGE for the prevention of disease. We then examine objections that have been raised against pursuing GGE and argue that these fail. We conclude that the moral case in favour of pursuing GGE is stronger than the case against...
August 2017: Journal of Applied Philosophy
https://www.readbyqxmd.com/read/28919592/the-study-on-the-lives-and-health-conditions-of-internees-in-santo-thomas-camp-of-philippines-based-on-mcanlis-s-the-war-in-manila-1941-1945
#13
Jueyeon Lee, Youngsoo Cho
When Japan invaded the Philippines, two missionary dentists (Dr. McAnlis and Dr. Boots) who were forced to leave Korea were captured and interned in the Santo Thomas camp in Manila. Japan continued to bombard and plunder the Philippines in the wake of the Pacific War following the Great East Asia policy, leading to serious inflation and material deficiency. More than 4,000 Allied citizens held in Santo Thomas camp without basic food and shelter. Santo Thomas Camp was equipped with the systems of the Japanese military medical officers and Western doctors of captivity based on the Geneva Conventions(1929)...
August 2017: Ŭi Sahak
https://www.readbyqxmd.com/read/28918520/derivation-of-human-induced-pluripotent-stem-cell-ipsc-lines-and-mechanism-of-pluripotency-historical-perspective-and-recent-advances
#14
REVIEW
Arvind Chhabra
Derivation of human embryonic stem cell (hES) lines in 1998 was not only a major technological breakthrough in the field of regenerative medicine; it also triggered a passionate debate about the ethical issues associated with the utilization of human embryos for derivation of hESC lines. Successful derivation of induced pluripotent stem cell (iPS) lines from human somatic cells with defined reprogramming factors by Shinya Yamanaka`s group in 2007 was another breakthrough that generated enormous excitement and hope for the development of donor-specific personalized cell replacement therapies (CRT) without the ethical dilemma associated with it...
September 16, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28918415/treatment-options-and-barriers-to-case-management-of-neonatal-pneumonia-in-india-a-protocol-for-a-scoping-review
#15
N Sreekumaran Nair, Leslie Edward Lewis, Shruti Murthy, Myron Anthony Godinho, Theophilus Lakiang, Bhumika T Venkatesh
INTRODUCTION: India contributes to the highest neonatal deaths globally. Case management is said to be the cornerstone of pneumonia control. Much of the published evidence focuses on children aged 1 to 59 months. This scoping review, thus, aims to identify the treatment options for and barriers to case management of neonatal pneumonia in India. METHODS AND ANALYSIS: This protocol is part of a series of three reviews on neonatal pneumonia in India. Studies addressing treatment of or barriers to case management of neonatal pneumonia in Indian context, published in English in peer-reviewed and indexed journals will be eligible for inclusion...
September 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28918414/a-protocol-of-a-cross-sectional-study-evaluating-an-online-tool-for-early-career-peer-reviewers-assessing-reports-of-randomised-controlled-trials
#16
Anthony Chauvin, David Moher, Doug Altman, David L Schriger, Sabina Alam, Sally Hopewell, Daniel R Shanahan, Alessandro Recchioni, Philippe Ravaud, Isabelle Boutron
INTRODUCTION: Systematic reviews evaluating the impact of interventions to improve the quality of peer review for biomedical publications highlighted that interventions were limited and have little impact. This study aims to compare the accuracy of early career peer reviewers who use an innovative online tool to the usual peer reviewer process in evaluating the completeness of reporting and switched primary outcomes in completed reports. METHODS AND ANALYSIS: This is a cross-sectional study of individual two-arm parallel-group randomised controlled trials (RCTs) published in the BioMed Central series medical journals, BMJ, BMJ Open and Annals of Emergency Medicine and indexed with the publication type 'Randomised Controlled Trial'...
September 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28916453/making-the-legal-and-ethical-case-for-universal-screening-for-postpartum-mood-and-anxiety-disorders-in-pediatric-primary-care
#17
Amy Lewis Gilbert, Casey Balio, Nerissa S Bauer
Postpartum depression (PPD), part of a larger spectrum of perinatal mood and anxiety disorders, affects up to 15% of women following the birth of an infant. Fathers may also be affected. PPD not only affects caregivers, but also impacts infants through mechanisms such as inadequate caregiver-infant interactions and non-adherence to safety practices. The negative impact on infants may extend across the life course through adulthood. This article seeks to move the needle toward universal screening for PPD using validated tools in pediatric primary care settings for new caregivers by making the legal and ethical case for this course of action in a manner that is both compelling and accessible for clinicians...
September 12, 2017: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/28915851/assessment-of-consent-models-as-an-ethical-consideration-in-the-conduct-of-prehospital-ambulance-randomised-controlled-clinical-trials-a-systematic-review
#18
Stephanie Armstrong, Adele Langlois, Despina Laparidou, Mark Dixon, Jason P Appleton, Philip M Bath, Helen Snooks, A Niroshan Siriwardena
BACKGROUND: We sought to understand the main ethical considerations when conducting clinical trials in the prehospital ambulance based setting. METHODS: A systematic review of the literature on randomised controlled trials in ambulance settings was undertaken. A search of eight databases identified published studies involving recruitment of ambulance service users. Four independent authors undertook abstract and full-text reviews to determine eligibility and extract relevant data...
September 16, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28915431/ethical-implications-of-location-and-accelerometer-measurement-in-health-research-studies-with-mobile-sensing-devices
#19
Daniel Fuller, Martine Shareck, Kevin Stanley
Quantification of individual behaviours using mobile sensing devices, including physical activity and spatial location, is a rapidly growing field in both academic research and the corporate world. In this case study, we summarize the literature examining the ethical aspects of mobile sensing and argue that a robust discussion about the ethical implications of mobile sensing for research purposes has not occurred sufficiently in the literature. Based on our literature summary and guided by basic ethical principles set out in Canadian, US, and International Ethics documents we propose four areas where further discussion should occur: consent, privacy and confidentiality, mitigating risk, and consideration of vulnerable populations...
September 12, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28914335/regulatory-experience-of-tops-an-internet-based-system-to-prevent-healthy-subjects-from-over-volunteering-for-uk-clinical-trials
#20
C Allen, G Francis, J Martin, M Boyce
PURPOSE: The aim was to review the use of The Over-volunteering Prevention System (TOPS) since the HRA began hosting it in 2013, and the Medicines and Healthcare products Regulatory Agency (MHRA) experience of monitoring its use by UK clinical research units. METHODS: The HRA searched the TOPS database for the number, type and location of units and the number of entries. The MHRA inspectors reviewed their findings from routine inspections. RESULTS: Twenty-two additional UK units registered to use TOPS during 2013-2016, making a total of 84 units since TOPS was established in 2002...
September 15, 2017: European Journal of Clinical Pharmacology
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