keyword
MENU ▼
Read by QxMD icon Read
search

Drug related issue

keyword
https://www.readbyqxmd.com/read/29149162/-switching-from-one-drug-therapy-to-another-with-the-same-therapeutic-indication-without-harms
#1
Valeria Belleudi, Antonio Addis
The loss of exclusivity from several drug therapies largely used bring new attention the issues of safety, efficacy and following the switch from one drug to another (i.e., biosimilar and/or generics) with the same indication. This is not a problem that can be related to regulatory or economical factors. The increase of patients exposed to chronic conditions and the introductions or more pharmaceutical alternatives with same therapeutic indications yield for studies able to verify the effectiveness and safety even when switch from more drugs is considered by practitioners...
November 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/29149154/philosophical-issues-and-psychological-variables-that-influence-the-determination-of-opioid-effectiveness-a-narrative-review
#2
Daniel Michael Doleys
BACKGROUND: The prescribing of opioids in the chronic pain setting is often based on the pharmacodynamics, pharmacokinetics, and pharmacogenetics of the drug obtained during development and clinical trials. However, the effectiveness of opioids varies widely and often appears to bear no relationship to the aforementioned variables. The impact of philosophical issues and psychological factors on determining how clinically effective opioid therapy is has often been over looked. OBJECTIVES: This manuscript provides a selective review and narrative summary of the philosophical issues and psychological factors which can influence opioid effectiveness...
November 2017: Pain Physician
https://www.readbyqxmd.com/read/29148566/factors-that-influence-the-provision-of-intrapartum-and-postnatal-care-by-skilled-birth-attendants-in-low-and-middle-income-countries-a-qualitative-evidence-synthesis
#3
REVIEW
Susan Munabi-Babigumira, Claire Glenton, Simon Lewin, Atle Fretheim, Harriet Nabudere
BACKGROUND: In many low- and middle-income countries women are encouraged to give birth in clinics and hospitals so that they can receive care from skilled birth attendants. A skilled birth attendant (SBA) is a health worker such as a midwife, doctor, or nurse who is trained to manage normal pregnancy and childbirth. (S)he is also trained to identify, manage, and refer any health problems that arise for mother and baby. The skills, attitudes and behaviour of SBAs, and the extent to which they work in an enabling working environment, impact on the quality of care provided...
November 17, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29137663/patent-landscape-of-neglected-tropical-diseases-an-analysis-of-worldwide-patent-families
#4
Folahanmi Tomiwa Akinsolu, Vitor Nobre de Paiva, Samuel Santos Souza, Orsolya Varga
BACKGROUND: "Neglected Tropical Diseases" (NTDs) affect millions of people in Africa, Asia and South America. The two primary ways of strategic interventions are "preventive chemotherapy and transmission control" (PCT), and "innovative and intensified disease management" (IDM). In the last 5 years, phenomenal progress has been achieved. However, it is crucial to intensify research effort into NTDs, because of the emerging drug resistance. According to the World Health Organization (WHO), the term NTDs covers 17 diseases, namely buruli ulcer, Chagas disease, dengue, dracunculiasis, echinococcosis, trematodiasis, human African trypanosomiasis, leishmaniasis, leprosy, lymphatic filariasis, onchocerciasis, rabies, schistosomiasis, soil-transmitted helminthes, taeniasis, trachoma, and yaws...
November 14, 2017: Globalization and Health
https://www.readbyqxmd.com/read/29136566/treatment-for-opioid-use-and-outcomes-in-older-adults-a-systematic-literature-review
#5
REVIEW
Anne Marie Carew, Catherine Comiskey
BACKGROUND: Historically, issues relating to problem substance use among older people have received little attention, and have only recently been recognised. METHODS: A literature review of relevant material was conducted in November 2015 to assess current outcome research among older adults treated for opioid dependence. Multiple electronic databases were searched and results were supplemented by grey literature, library and online searches, and relevant references within selected articles...
November 7, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29134510/drug-design-for-alk-positive-nsclc-an-integrated-pharmacophore-based-3d-qsar-and-virtual-screening-strategy
#6
Nivya James, V Shanthi, K Ramanathan
The increasing death rates related to anaplastic lymphoma kinase (ALK)-positive lung cancer culminated in a significant interest in the discovery of novel inhibitors for ALK. In the present research work, pharmacophore-based 3D QSAR modeling and virtual screening strategy have been carried out to address these issues. Initially, a five-point pharmacophore model was developed using the biological data of 50 compounds which includes an FDA-approved ALK inhibitor, crizotinib. Using the generated pharmacophore, a 3D QSAR model was developed and used as a query to screen the DrugBank database...
November 13, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/29132552/intravenous-drug-abuse-is-a-risk-factor-in-the-failure-of-two-stage-treatment-for-infected-total-hip-arthroplasty
#7
Yu-Jie Su, Sung-Yen Lin, Hsuan-Ti Huang, Je-Ken Chang, Chung-Hwan Chen
Reinfection after two-stage revision hip arthroplasty (RHA) is still a complex issue. Only few studies revealed the factors affecting the success rate in the treatment of periprosthetic hip infection (PHI), especially risk factors. A retrospective study was conducted using records of 30 patients underwent two-stage RHA for infected total hip arthroplasty (THA). Treatment was defined as successful if a patient did not need any reoperation or invasive procedure such as image-guided drainage during the two years after reimplantation...
December 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/29131621/expanding-the-armory-predicting-and-tuning-covalent-warhead-reactivity
#8
Richard Lonsdale, Jonathan Burgess, Nicola Colclough, Nichola L Davies, Eva M Lenz, Alexandra Orton, Richard A Ward
Targeted covalent inhibition is an established approach for increasing the potency and selectivity of potential drug candidates, as well as identifying potent and selective tool compounds for target validation studies. It is evident that identification of reversible recognition elements is essential for selective covalent inhibition, but this must also be achieved with the appropriate level of inherent reactivity of the reactive functionality (or 'warhead'). Structural changes that increase or decrease warhead reactivity, guided by methods to predict the effect of those changes, have the potential to tune warhead reactivity and negate issues related to potency and/or toxicity...
November 13, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29130384/characterising-the-growth-in-palliative-care-prescribing-2011-2015-analysis-of-national-medical-and-non-medical-activity
#9
Lucy Ziegler, Michael I Bennett, Matt Mulvey, Tim Hamilton, Alison Blenkinsopp
BACKGROUND: The role of non-medical prescribers working in palliative care has been expanding in recent years and prescribers report improvements in patient care, patient safety, better use of health professionals' skills and more flexible team working. Despite this, there is a lack of empirical evidence to demonstrate its clinical and economic impact, limiting our understanding of the future role of non-medical prescribers within a healthcare system serving an increasing number of people with palliative care needs...
November 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/29130358/gelatinase-inhibitors-a-patent-review-2011-2017
#10
Xun Li
Gelatinase represents a promising biotarget in new drug development as it is closely related to various pathological events, including but not limited to neoplasm, aging, respiratory and neurological disorders. Gelatinase inhibitors are thereby designated as chemotherapeutics or as mechanistic probe to figure out the unrecognized functions of MMP members. Areas covered: The focus of this article is to highlight recently issued patents concerning the naturally available or synthetic gelatinase inhibitors (2011-2017), where the chemical structures, SAR investigation, biological application...
November 12, 2017: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/29128840/effect-of-enrofloxacin-on-the-proteome-of-earthworms
#11
Xiaoxu Lu, Yinsheng Li, Michelle Thunders, Cory Matthew, Xiuhong Wang, Xiaojie Ai, Xinchu Zhou, Jiangping Qiu
The environmental and human health risks of veterinary drugs are becoming public health issues. Enrofloxacin (EF) is an extensively used animal-specific antibacterial agent that leaves drug residues in the environment. This study investigated the proteomic response of the earthworm Eisenia fetida to EF exposure. Earthworms were exposed to EF in soil at 1-500mg·kg(-1), and samples were collected at intervals during a 28 day period. The extracted proteins were separated by two dimensional electrophoresis to detect differentially expressed proteins (DEPs) in EF-exposed earthworms...
November 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29128470/is-it-worth-it-or-possible-to-measure-what-matters-to-patients-with-epilepsy-and-their-caregivers
#12
Maria Grazia Celani, Teresa Anna Cantisani, Angelo Bignamini, Sara Macone, Rossella Papetti, Luisa Baiocco
OBJECTIVE: The objective of this study was to collect perspectives, ideas, and values of people affected by epilepsy and their carer to include them in new research in this area. DESIGN: This is a semiquantitative study analyzing needs, emotions, and medical issues emerging from focus groups with patients and carers divided in three severity levels of disease. PARTICIPANTS: The participants were 25 patients and 36 carers attending outpatients' service of tertiary epilepsy center in Umbria, Italy...
November 8, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29127749/-is-it-possible-to-improve-long-term-compliance-of-patients-to-statin-therapy
#13
Vladimír Soška, Ondřej Kyselák
Statins are key drugs for patients in secondary prevention of cardiovascular disease, as well as for primary prevention patients at high or very high risk of fatal cardiovascular events. However, long-term compliance of patients to statin therapy is relatively low, decreasing with the time of statin use; moreover a significant proportion of patients stop statins medication over the course of several years. To the early termination of statin treatment often contributes apprehension of the occurence of statin´s side effects (i...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29126906/development-and-characterization-of-an-organic-solvent-free-proliposomal-formulation-of-busulfan-using-quality-by-design-approach
#14
Dhawal Chobisa, Ketan Patel, Jasmin Monpara, Mayank Patel, Pradeep Vavia
Parenteral administration of Busulfan (BU) conquers the bioavailability and biovariability related issues of oral BU by maintaining the plasma drug concentration in therapeutic range with minimal fluctuations thereby significantly reducing the side effects. Busulfex(®) is the only commercially available parenteral formulation of BU composed of organic solvents N, N-dimethylacetamide and polyethylene glycol 400. Since, BU is highly susceptible to hydrolytic degradation; Busulfex(®) has poor physical and chemical stability in IV fluids...
November 7, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29126557/-keratoacanthomas-on-recent-tattoos-two-cases
#15
N Kluger, D Douvin, F Dupuis-Fourdan, J-M Doumecq-Lacoste, V Descamps
BACKGROUND: Increasing numbers of reports of rapidly arising, isolated or eruptive keratoacanthomas (KA) and squamous cell carcinomas (CSC) on the red part of tattoos tend to suggest a non-fortuitous link with the procedure. We report herein two different presentations of KAs on tattoos: one patient with multiple eruptive KAs on sun-exposed areas of a recent red tattoo and another with a solitary lesion on a recent tattoo. We discuss the issues related to the distinction between KAs and CSCs in this particular context...
November 7, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29125795/impurities-in-oligonucleotide-drug-substances-and-drug-products
#16
Daniel Capaldi, Andy Teasdale, Scott Henry, Nadim Akhtar, Cathaline den Besten, Samantha Gao-Sheridan, Matthias Kretschmer, Neal Sharpe, Ben Andrews, Brigitte Burm, Jeffrey Foy
This white paper, which is the 10th in a series intended to address issues associated with the development of therapeutic oligonucleotides, examines the subject of product-related impurities. The authors consider chemistry and safety aspects and advance arguments in favor of platform approaches to impurity identification and qualification. Reporting, identification, and qualification thresholds suitable for product-related impurities of therapeutic oligonucleotides are proposed.
November 10, 2017: Nucleic Acid Therapeutics
https://www.readbyqxmd.com/read/29125297/identification-of-protein-ligand-binding-sites-by-sequence-information-and-ensemble-classifier
#17
Yijie Ding, Jijun Tang, Fei Guo
Identifying protein-ligand binding sites is an important process in drug discovery and structure-based drug design. Traditional experimental methods are expensive and time-consuming for detecting protein-ligand binding sites. Therefore, computational approaches provide many effective strategies to deal with this issue. In recent years, most of computational methods are based on structure information of proteins. However, these methods are limited in the common scenario, where both the sequence of protein target is known and sufficient 3D structure information is available...
November 10, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29124666/study-design-and-evaluation-of-risk-minimization-measures-a-review-of-studies-submitted-to-the-european-medicines-agency-for-cardiovascular-endocrinology-and-metabolic-drugs
#18
Giampiero Mazzaglia, Sabine M J Straus, Peter Arlett, Daniela da Silva, Heidi Janssen, June Raine, Enrica Alteri
INTRODUCTION: Studies measuring the effectiveness of risk minimization measures (RMMs) submitted by pharmaceutical companies to the European Medicines Agency are part of the post-authorization regulatory requirements and represent an important source of data covering a range of medicinal products and safety-related issues. Their objectives, design, and the associated regulatory outcomes were reviewed, and conclusions were drawn that may support future progress in risk minimization evaluation...
November 9, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29120895/leaving-the-nest-anticipatory-guidance-for-the-college-bound-youth
#19
Sharnendra Sidhu, Andrew Adesman
PURPOSE OF REVIEW: The number of students enrolling in college is on the rise; however, the number of students dropping out is increasing as well. Given that the transition to attending college poses challenges with independent academic functioning, social adjustment, health behaviors, and lifestyle choices, the purpose of this review is to describe some of the issues that these students will encounter so that pediatricians can help teens who are going to college successfully transition to their new academic, social, and living environment...
December 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29119168/nanowire-sensors-monitor-bacterial-growth-kinetics-and-response-to-antibiotics
#20
B Ibarlucea, T Rim, C K Baek, J A G M de Visser, L Baraban, G Cuniberti
Miniaturized and cost-efficient methods aiming at high throughput analysis of microbes are of great importance for the surveillance and control of infectious diseases and the related issue of antimicrobial resistance. Here we demonstrate a miniature nanosensor based on a honeycomb-patterned silicon nanowire field effect transistor (FET) capable of detection of bacterial growth and antibiotic response in microbiologically relevant nutrient media. We determine the growth kinetics and metabolic state of Escherichia coli cells in undiluted media via the quantification of changes in the source-drain current caused by varying pH values...
November 9, 2017: Lab on a Chip
keyword
keyword
20908
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"